C6ORF203

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.32941544
2ATP synthesis coupled proton transport (GO:0015986)4.98911048
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.98911048
4protein complex biogenesis (GO:0070271)4.98897621
5establishment of protein localization to mitochondrial membrane (GO:0090151)4.79558991
6mitochondrial respiratory chain complex assembly (GO:0033108)4.66928901
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.66433091
8mitochondrial respiratory chain complex I assembly (GO:0032981)4.62347596
9NADH dehydrogenase complex assembly (GO:0010257)4.62347596
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.62347596
11chaperone-mediated protein transport (GO:0072321)4.52975149
12respiratory chain complex IV assembly (GO:0008535)4.19536482
13respiratory electron transport chain (GO:0022904)4.05892952
14electron transport chain (GO:0022900)4.01754937
15protein neddylation (GO:0045116)3.89842556
16cytochrome complex assembly (GO:0017004)3.86622835
17DNA double-strand break processing (GO:0000729)3.66340487
18nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.52559351
19cullin deneddylation (GO:0010388)3.51505136
20exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.43486487
21water-soluble vitamin biosynthetic process (GO:0042364)3.39500506
22behavioral response to nicotine (GO:0035095)3.33094722
23proteasome assembly (GO:0043248)3.28074648
24protein deneddylation (GO:0000338)3.25575958
25tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.18356778
26RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.18356778
27negative regulation of telomere maintenance (GO:0032205)3.17427554
28nonmotile primary cilium assembly (GO:0035058)3.14308577
29protein-cofactor linkage (GO:0018065)3.13884321
30intracellular protein transmembrane import (GO:0044743)3.13537194
31ubiquinone biosynthetic process (GO:0006744)3.11206345
32mannosylation (GO:0097502)3.07606495
33ATP biosynthetic process (GO:0006754)3.06380631
34intraciliary transport (GO:0042073)3.03920853
35DNA deamination (GO:0045006)3.02090440
36hydrogen ion transmembrane transport (GO:1902600)2.97092305
37ubiquinone metabolic process (GO:0006743)2.97081318
38peptidyl-histidine modification (GO:0018202)2.96821884
39regulation of mitochondrial translation (GO:0070129)2.94110521
40transcription elongation from RNA polymerase III promoter (GO:0006385)2.93502347
41termination of RNA polymerase III transcription (GO:0006386)2.93502347
42regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.91034774
43regulation of mitotic spindle checkpoint (GO:1903504)2.91034774
44maturation of 5.8S rRNA (GO:0000460)2.88882567
45purine nucleoside triphosphate biosynthetic process (GO:0009145)2.88602821
46purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.86026961
47DNA damage response, detection of DNA damage (GO:0042769)2.83081403
48protein localization to cilium (GO:0061512)2.82492796
49proton transport (GO:0015992)2.81268722
50protein targeting to mitochondrion (GO:0006626)2.80229487
51regulation of hexokinase activity (GO:1903299)2.79051838
52regulation of glucokinase activity (GO:0033131)2.79051838
53platelet dense granule organization (GO:0060155)2.78802319
54establishment of protein localization to mitochondrion (GO:0072655)2.76889612
55hydrogen transport (GO:0006818)2.75418790
56protein localization to mitochondrion (GO:0070585)2.73889717
57pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.73821979
58iron-sulfur cluster assembly (GO:0016226)2.66657470
59metallo-sulfur cluster assembly (GO:0031163)2.66657470
60protein K6-linked ubiquitination (GO:0085020)2.66010684
61preassembly of GPI anchor in ER membrane (GO:0016254)2.63617869
62pyrimidine nucleobase catabolic process (GO:0006208)2.59989740
63L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.59519043
64tRNA processing (GO:0008033)2.59183704
65negative regulation of transcription regulatory region DNA binding (GO:2000678)2.58772201
66branched-chain amino acid catabolic process (GO:0009083)2.58694239
67pseudouridine synthesis (GO:0001522)2.57522342
68protein polyglutamylation (GO:0018095)2.57365473
69cellular ketone body metabolic process (GO:0046950)2.57267067
70somite development (GO:0061053)2.54568312
71response to pheromone (GO:0019236)2.53993146
72base-excision repair, AP site formation (GO:0006285)2.51638670
73chromatin remodeling at centromere (GO:0031055)2.50612650
74resolution of meiotic recombination intermediates (GO:0000712)2.50279926
75negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.50196661
76quinone biosynthetic process (GO:1901663)2.49144434
77mitochondrial transport (GO:0006839)2.48585331
78ribonucleoside triphosphate biosynthetic process (GO:0009201)2.48287231
79positive regulation of mitochondrial fission (GO:0090141)2.47503006
80aldehyde catabolic process (GO:0046185)2.47485928
81L-fucose catabolic process (GO:0042355)2.46862758
82fucose catabolic process (GO:0019317)2.46862758
83L-fucose metabolic process (GO:0042354)2.46862758
84oxidative phosphorylation (GO:0006119)2.46766050
85GPI anchor metabolic process (GO:0006505)2.42697584
86replication fork processing (GO:0031297)2.41545430
87organelle disassembly (GO:1903008)2.40945165
88otic vesicle formation (GO:0030916)2.40225888
89intracellular protein transmembrane transport (GO:0065002)2.39166317
90cellular component biogenesis (GO:0044085)2.36623129
91positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.35059081
92ketone body metabolic process (GO:1902224)2.34389164
93regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.33326859
94CENP-A containing nucleosome assembly (GO:0034080)2.33126437
95nucleoside triphosphate biosynthetic process (GO:0009142)2.32181976
96regulation of cellular amino acid metabolic process (GO:0006521)2.31941850
97L-methionine biosynthetic process (GO:0071265)2.30336008
98amino acid salvage (GO:0043102)2.30336008
99L-methionine salvage (GO:0071267)2.30336008
100C-terminal protein lipidation (GO:0006501)2.30197684

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.96699656
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.83764750
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.53373628
4HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.17709651
5ZNF274_21170338_ChIP-Seq_K562_Hela2.98570285
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.69534119
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.50681805
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.49093555
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.46842352
10VDR_22108803_ChIP-Seq_LS180_Human2.42518964
11ELK1_19687146_ChIP-ChIP_HELA_Human2.39799591
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.38579820
13IGF1R_20145208_ChIP-Seq_DFB_Human2.28900408
14EWS_26573619_Chip-Seq_HEK293_Human2.21319116
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20846155
16EZH2_22144423_ChIP-Seq_EOC_Human2.20372010
17VDR_23849224_ChIP-Seq_CD4+_Human2.17014789
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.09807807
19FUS_26573619_Chip-Seq_HEK293_Human2.09350368
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06047253
21TAF15_26573619_Chip-Seq_HEK293_Human2.04056615
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02436605
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.02258403
24GBX2_23144817_ChIP-Seq_PC3_Human1.84150553
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.80291938
26MYC_18940864_ChIP-ChIP_HL60_Human1.78924176
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73369272
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72577307
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71753394
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70125339
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69341083
32FOXP3_21729870_ChIP-Seq_TREG_Human1.69120075
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.68775355
34P300_19829295_ChIP-Seq_ESCs_Human1.67789138
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54179926
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48847349
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46696711
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45098424
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.44628867
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44486945
41TP53_22573176_ChIP-Seq_HFKS_Human1.44251022
42IRF1_19129219_ChIP-ChIP_H3396_Human1.43940638
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42825019
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42511503
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.40401898
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39562592
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39524097
48MYC_18555785_ChIP-Seq_MESCs_Mouse1.35379115
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.33625611
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30186968
51NANOG_19829295_ChIP-Seq_ESCs_Human1.24691164
52SOX2_19829295_ChIP-Seq_ESCs_Human1.24691164
53ER_23166858_ChIP-Seq_MCF-7_Human1.22809675
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21798659
55* GABP_19822575_ChIP-Seq_HepG2_Human1.21161862
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19843017
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.19663024
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19361616
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19296933
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17936732
61CBP_20019798_ChIP-Seq_JUKART_Human1.17936732
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15208196
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14321185
64TTF2_22483619_ChIP-Seq_HELA_Human1.12673808
65HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.12458247
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.10279464
67RNF2_27304074_Chip-Seq_NSC_Mouse1.09975728
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08987015
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.07728592
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06914876
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06579767
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05161490
73DCP1A_22483619_ChIP-Seq_HELA_Human1.03599311
74AR_25329375_ChIP-Seq_VCAP_Human1.03449831
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03011188
76MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01997434
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01345090
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00892201
79YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00314593
80FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00191332
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.00191332
82E2F1_18555785_ChIP-Seq_MESCs_Mouse0.99765804
83HTT_18923047_ChIP-ChIP_STHdh_Human0.99035265
84AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98596157
85NCOR_22424771_ChIP-Seq_293T_Human0.97724536
86TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96881620
87AR_20517297_ChIP-Seq_VCAP_Human0.96205885
88SOX2_16153702_ChIP-ChIP_HESCs_Human0.96077499
89SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95579246
90NFE2_27457419_Chip-Seq_LIVER_Mouse0.95059831
91SMAD4_21799915_ChIP-Seq_A2780_Human0.94824328
92MYC_19030024_ChIP-ChIP_MESCs_Mouse0.93918767
93BCAT_22108803_ChIP-Seq_LS180_Human0.93752759
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93421206
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92828792
96PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92330329
97TCF4_22108803_ChIP-Seq_LS180_Human0.90827132
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90814845
99CRX_20693478_ChIP-Seq_RETINA_Mouse0.90624595
100ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90130836

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.25189881
2MP0001529_abnormal_vocalization2.65845035
3MP0008877_abnormal_DNA_methylation2.48076644
4MP0003880_abnormal_central_pattern2.42682542
5MP0008789_abnormal_olfactory_epithelium2.30319015
6MP0002102_abnormal_ear_morphology2.27773042
7MP0001984_abnormal_olfaction2.19523832
8MP0002837_dystrophic_cardiac_calcinosis2.13154997
9MP0000372_irregular_coat_pigmentation2.12401205
10MP0006072_abnormal_retinal_apoptosis2.11086363
11MP0008058_abnormal_DNA_repair2.08186630
12MP0003646_muscle_fatigue2.05579942
13MP0002822_catalepsy2.04951152
14MP0002653_abnormal_ependyma_morphology2.02503467
15MP0002736_abnormal_nociception_after1.97059124
16MP0002234_abnormal_pharynx_morphology1.95197289
17MP0005499_abnormal_olfactory_system1.92540887
18MP0005394_taste/olfaction_phenotype1.92540887
19MP0002938_white_spotting1.91020188
20MP0003122_maternal_imprinting1.90125016
21MP0003136_yellow_coat_color1.89347301
22MP0006276_abnormal_autonomic_nervous1.87106374
23MP0005551_abnormal_eye_electrophysiolog1.85965749
24MP0003718_maternal_effect1.84111927
25MP0008875_abnormal_xenobiotic_pharmacok1.70286552
26MP0001968_abnormal_touch/_nociception1.69818512
27MP0002638_abnormal_pupillary_reflex1.69772188
28MP0004147_increased_porphyrin_level1.68413125
29MP0004142_abnormal_muscle_tone1.67480679
30MP0003121_genomic_imprinting1.56575321
31MP0006036_abnormal_mitochondrial_physio1.54609541
32MP0004133_heterotaxia1.51211792
33MP0001293_anophthalmia1.49903238
34MP0005253_abnormal_eye_physiology1.48227184
35MP0003011_delayed_dark_adaptation1.46386057
36MP0003186_abnormal_redox_activity1.44515821
37MP0009046_muscle_twitch1.41813692
38MP0001485_abnormal_pinna_reflex1.40495066
39MP0002272_abnormal_nervous_system1.37981709
40MP0009745_abnormal_behavioral_response1.34997985
41MP0008995_early_reproductive_senescence1.34762016
42MP0000049_abnormal_middle_ear1.34611009
43MP0000778_abnormal_nervous_system1.29799982
44MP0003195_calcinosis1.27607534
45MP0002876_abnormal_thyroid_physiology1.26808252
46MP0005084_abnormal_gallbladder_morpholo1.26384359
47MP0000631_abnormal_neuroendocrine_gland1.24946599
48MP0004145_abnormal_muscle_electrophysio1.23670272
49MP0008872_abnormal_physiological_respon1.21481233
50MP0009697_abnormal_copulation1.17067540
51MP0000647_abnormal_sebaceous_gland1.16115025
52MP0010094_abnormal_chromosome_stability1.12135253
53MP0002160_abnormal_reproductive_system1.11391568
54MP0002277_abnormal_respiratory_mucosa1.10307987
55MP0002735_abnormal_chemical_nociception1.10126796
56MP0002751_abnormal_autonomic_nervous1.09172346
57MP0002233_abnormal_nose_morphology1.07424836
58MP0005646_abnormal_pituitary_gland1.07069045
59MP0003787_abnormal_imprinting1.06242075
60MP0001905_abnormal_dopamine_level1.03400929
61MP0010030_abnormal_orbit_morphology1.03208103
62MP0004043_abnormal_pH_regulation1.01236124
63MP0003786_premature_aging1.00101120
64MP0003693_abnormal_embryo_hatching0.98904071
65MP0001986_abnormal_taste_sensitivity0.98850284
66MP0001486_abnormal_startle_reflex0.98594915
67MP0000427_abnormal_hair_cycle0.97990451
68MP0005389_reproductive_system_phenotype0.96675235
69MP0005379_endocrine/exocrine_gland_phen0.96420707
70MP0002557_abnormal_social/conspecific_i0.95132653
71MP0002210_abnormal_sex_determination0.94501942
72MP0005645_abnormal_hypothalamus_physiol0.93480051
73MP0006035_abnormal_mitochondrial_morpho0.93016037
74MP0002752_abnormal_somatic_nervous0.92913052
75MP0001764_abnormal_homeostasis0.92547895
76MP0004885_abnormal_endolymph0.92393883
77MP0005195_abnormal_posterior_eye0.91774044
78MP0003806_abnormal_nucleotide_metabolis0.91633768
79MP0005085_abnormal_gallbladder_physiolo0.89417592
80MP0002095_abnormal_skin_pigmentation0.88881654
81MP0002067_abnormal_sensory_capabilities0.88633193
82MP0002572_abnormal_emotion/affect_behav0.87859777
83MP0004924_abnormal_behavior0.87698110
84MP0005386_behavior/neurological_phenoty0.87698110
85MP0003567_abnormal_fetal_cardiomyocyte0.86736987
86MP0000026_abnormal_inner_ear0.86560899
87MP0003890_abnormal_embryonic-extraembry0.85630467
88MP0005332_abnormal_amino_acid0.85620334
89MP0001929_abnormal_gametogenesis0.85339500
90MP0003137_abnormal_impulse_conducting0.85187083
91MP0002734_abnormal_mechanical_nocicepti0.84325034
92MP0002282_abnormal_trachea_morphology0.84100474
93MP0002184_abnormal_innervation0.83658074
94MP0004215_abnormal_myocardial_fiber0.83005653
95MP0001963_abnormal_hearing_physiology0.82996761
96MP0002064_seizures0.82924904
97MP0008932_abnormal_embryonic_tissue0.82681697
98MP0003937_abnormal_limbs/digits/tail_de0.81896618
99MP0004270_analgesia0.81017918
100MP0009379_abnormal_foot_pigmentation0.79183776

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.40489741
2Abnormal mitochondria in muscle tissue (HP:0008316)4.04775860
3Mitochondrial inheritance (HP:0001427)4.04316539
4Acute encephalopathy (HP:0006846)3.93901930
5Increased CSF lactate (HP:0002490)3.77243156
6Progressive macrocephaly (HP:0004481)3.71130398
7Medial flaring of the eyebrow (HP:0010747)3.62234073
8Hepatocellular necrosis (HP:0001404)3.55611938
9Molar tooth sign on MRI (HP:0002419)3.51180813
10Abnormality of midbrain morphology (HP:0002418)3.51180813
11Lipid accumulation in hepatocytes (HP:0006561)3.50173907
12Pancreatic cysts (HP:0001737)3.45989612
13Increased hepatocellular lipid droplets (HP:0006565)3.44816637
14Hepatic necrosis (HP:0002605)3.38303636
15Pancreatic fibrosis (HP:0100732)3.34840313
16Abnormality of the labia minora (HP:0012880)3.27595322
17True hermaphroditism (HP:0010459)3.27172835
18Gait imbalance (HP:0002141)3.09333820
19Congenital primary aphakia (HP:0007707)3.03824366
20Cerebral edema (HP:0002181)2.96743320
21Renal Fanconi syndrome (HP:0001994)2.95954392
22Nephronophthisis (HP:0000090)2.93753087
233-Methylglutaconic aciduria (HP:0003535)2.90879157
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.88784527
25Decreased activity of mitochondrial respiratory chain (HP:0008972)2.88784527
26Nephrogenic diabetes insipidus (HP:0009806)2.84824456
27Genital tract atresia (HP:0001827)2.54917478
28Methylmalonic acidemia (HP:0002912)2.54083655
29Lactic acidosis (HP:0003128)2.53193348
30Increased serum lactate (HP:0002151)2.51045135
31Abnormality of alanine metabolism (HP:0010916)2.48956827
32Hyperalaninemia (HP:0003348)2.48956827
33Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.48956827
34Sclerocornea (HP:0000647)2.48673493
35Increased intramyocellular lipid droplets (HP:0012240)2.48144357
36Vaginal atresia (HP:0000148)2.48112767
37Optic disc pallor (HP:0000543)2.42461219
38Hyperglycinemia (HP:0002154)2.39027427
39Septo-optic dysplasia (HP:0100842)2.34381732
40Respiratory failure (HP:0002878)2.32488106
41Renal cortical cysts (HP:0000803)2.30448747
42Colon cancer (HP:0003003)2.29685553
43Abnormality of the renal medulla (HP:0100957)2.27999801
44Type I transferrin isoform profile (HP:0003642)2.27100004
45Congenital stationary night blindness (HP:0007642)2.26288350
46Increased muscle lipid content (HP:0009058)2.17362644
47Lethargy (HP:0001254)2.15555425
48Abnormality of the renal cortex (HP:0011035)2.12751794
49Methylmalonic aciduria (HP:0012120)2.10467747
50Poor coordination (HP:0002370)2.10347685
51Aplasia/Hypoplasia of the tongue (HP:0010295)2.08053658
52Abnormality of urine glucose concentration (HP:0011016)2.07762572
53Glycosuria (HP:0003076)2.07762572
54CNS demyelination (HP:0007305)2.01491545
55Exercise intolerance (HP:0003546)2.00054772
56Abolished electroretinogram (ERG) (HP:0000550)1.98628589
57Postaxial hand polydactyly (HP:0001162)1.95896306
58Leukodystrophy (HP:0002415)1.95501290
59Optic nerve hypoplasia (HP:0000609)1.95186968
60Exertional dyspnea (HP:0002875)1.94806796
61Abnormality of renal resorption (HP:0011038)1.93100030
62Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.92838115
63Abnormality of serum amino acid levels (HP:0003112)1.91843866
64Type II lissencephaly (HP:0007260)1.91742075
65Anencephaly (HP:0002323)1.91555068
66Hyperglycinuria (HP:0003108)1.91153885
67Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89067382
68Abnormal protein N-linked glycosylation (HP:0012347)1.89067382
69Abnormal protein glycosylation (HP:0012346)1.89067382
70Abnormal glycosylation (HP:0012345)1.89067382
71Abnormality of serine family amino acid metabolism (HP:0010894)1.88621748
72Abnormality of glycine metabolism (HP:0010895)1.88621748
73Postaxial foot polydactyly (HP:0001830)1.88356431
74Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87274615
75Chronic hepatic failure (HP:0100626)1.85737554
76Congenital, generalized hypertrichosis (HP:0004540)1.82319704
77Male pseudohermaphroditism (HP:0000037)1.81319234
78Rib fusion (HP:0000902)1.80707236
79Short tibia (HP:0005736)1.79707109
80Aplasia/Hypoplasia of the tibia (HP:0005772)1.79693771
81Cystic liver disease (HP:0006706)1.78778387
82Oligodactyly (hands) (HP:0001180)1.78532111
83Intestinal atresia (HP:0011100)1.77327003
84Supernumerary spleens (HP:0009799)1.75921397
85Adrenal hypoplasia (HP:0000835)1.75117084
86Hypothermia (HP:0002045)1.73389906
87Increased serum pyruvate (HP:0003542)1.71985513
88Absent septum pellucidum (HP:0001331)1.71589965
89Generalized aminoaciduria (HP:0002909)1.70404698
90Degeneration of anterior horn cells (HP:0002398)1.69246388
91Abnormality of the anterior horn cell (HP:0006802)1.69246388
92Inability to walk (HP:0002540)1.69027110
93Broad-based gait (HP:0002136)1.69005999
94X-linked dominant inheritance (HP:0001423)1.67462332
95Hyperphosphaturia (HP:0003109)1.66817166
96Specific learning disability (HP:0001328)1.65843578
97Preaxial hand polydactyly (HP:0001177)1.64983226
98Occipital encephalocele (HP:0002085)1.64601894
99Aganglionic megacolon (HP:0002251)1.64249548
100Broad foot (HP:0001769)1.64130847

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.48983050
2STK162.81325496
3WNK32.79532194
4FRK2.57064766
5BMPR1B2.55409147
6NUAK12.52181863
7MAP4K22.44580828
8TRIM282.33506190
9PINK12.15010426
10BUB12.07157856
11BCKDK1.98468470
12VRK11.98239690
13WEE11.88480149
14TNIK1.81875108
15MAPK131.80068120
16EIF2AK31.79881113
17CASK1.67865566
18CSNK1G31.65314486
19ADRBK21.63228844
20ZAK1.59463020
21MAP3K41.58777439
22MAP2K71.56808898
23CSNK1G21.55924790
24DYRK21.54313900
25TAF11.50691834
26CSNK1G11.48516885
27ERBB31.48459710
28BRSK21.47993734
29GRK11.45874525
30NEK11.44605169
31MKNK21.43941343
32PLK31.39959998
33MST41.39597529
34CSNK1A1L1.30395864
35WNK41.28225338
36SRPK11.27341851
37PBK1.23932243
38PLK21.21419250
39MARK11.20521801
40MAP3K121.19310938
41BCR1.17473402
42OBSCN1.15422861
43NME11.14159932
44EPHA41.07882232
45PLK41.07830148
46PHKG21.05953551
47PHKG11.05953551
48MKNK11.05620336
49EIF2AK21.01591292
50CDC71.01474036
51ACVR1B1.00327471
52PRKCG0.95503566
53INSRR0.95131547
54DYRK30.93422403
55PAK30.92827130
56PLK10.90894583
57PNCK0.89618248
58LIMK10.85283575
59PDK20.78947089
60STK390.75920843
61OXSR10.73656609
62TLK10.71863530
63EIF2AK10.70607239
64PRKCE0.69539863
65TTK0.66560369
66RPS6KA40.65683139
67ATR0.58687255
68EPHB20.57870423
69TGFBR10.57320146
70GRK50.56881931
71BRSK10.56782683
72TIE10.56661270
73ADRBK10.54852538
74CSNK1A10.54270267
75CHEK20.54248074
76CAMK2A0.52330987
77MAPKAPK30.50654310
78MAPKAPK50.50033589
79CSNK2A10.49690909
80CSNK2A20.47334592
81PRKACA0.46668402
82FLT30.46609945
83TSSK60.45865355
84AURKB0.41992635
85STK38L0.41170672
86AURKA0.40876649
87CSNK1D0.39188075
88PKN10.38745161
89MINK10.38261338
90RPS6KA50.38049672
91ATM0.37865927
92CSNK1E0.36958009
93CAMK2D0.36546008
94GRK70.35797450
95CDK80.35274134
96STK30.34924469
97CCNB10.34449653
98CDK30.32800776
99PRKG10.32552531
100PRKCI0.32165301

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.80360154
2Parkinsons disease_Homo sapiens_hsa050123.18100757
3Protein export_Homo sapiens_hsa030603.12513186
4Proteasome_Homo sapiens_hsa030502.82938206
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.57534935
6Ribosome_Homo sapiens_hsa030102.54070522
7RNA polymerase_Homo sapiens_hsa030202.32499617
8Huntingtons disease_Homo sapiens_hsa050162.23124661
9Alzheimers disease_Homo sapiens_hsa050102.16122324
10Propanoate metabolism_Homo sapiens_hsa006402.13956142
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.06468123
12Homologous recombination_Homo sapiens_hsa034402.04541786
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.97329850
14Basal transcription factors_Homo sapiens_hsa030221.89998139
15Mismatch repair_Homo sapiens_hsa034301.82082479
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81779031
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76209893
18Cardiac muscle contraction_Homo sapiens_hsa042601.75317407
19Butanoate metabolism_Homo sapiens_hsa006501.70548864
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.69486688
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65812649
22Fanconi anemia pathway_Homo sapiens_hsa034601.59293178
23RNA degradation_Homo sapiens_hsa030181.58161124
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.56149001
25Nucleotide excision repair_Homo sapiens_hsa034201.49000843
26Fatty acid elongation_Homo sapiens_hsa000621.43848206
27Caffeine metabolism_Homo sapiens_hsa002321.42957258
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40546803
29Peroxisome_Homo sapiens_hsa041461.38160118
30Non-homologous end-joining_Homo sapiens_hsa034501.34214241
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.31187478
32Phototransduction_Homo sapiens_hsa047441.28458629
33Folate biosynthesis_Homo sapiens_hsa007901.27812370
34Base excision repair_Homo sapiens_hsa034101.26941325
35Pyruvate metabolism_Homo sapiens_hsa006201.16520723
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.15013676
37Pyrimidine metabolism_Homo sapiens_hsa002401.14893252
38Steroid biosynthesis_Homo sapiens_hsa001001.13881081
39One carbon pool by folate_Homo sapiens_hsa006701.11447546
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11167357
41DNA replication_Homo sapiens_hsa030301.10167101
42Sulfur metabolism_Homo sapiens_hsa009201.09800988
43Tryptophan metabolism_Homo sapiens_hsa003801.08799581
44Nicotine addiction_Homo sapiens_hsa050331.06458619
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06220301
46Linoleic acid metabolism_Homo sapiens_hsa005911.03270629
47Sulfur relay system_Homo sapiens_hsa041221.03223342
48Selenocompound metabolism_Homo sapiens_hsa004501.02585018
49Chemical carcinogenesis_Homo sapiens_hsa052041.01225159
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.00267654
51beta-Alanine metabolism_Homo sapiens_hsa004100.99438098
52Spliceosome_Homo sapiens_hsa030400.98984654
53Purine metabolism_Homo sapiens_hsa002300.97756688
54RNA transport_Homo sapiens_hsa030130.96279347
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.95613829
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90330531
57Metabolic pathways_Homo sapiens_hsa011000.90141338
58Nitrogen metabolism_Homo sapiens_hsa009100.89861767
59Collecting duct acid secretion_Homo sapiens_hsa049660.89618755
60Fatty acid degradation_Homo sapiens_hsa000710.89256853
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87665308
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87531800
63Glutathione metabolism_Homo sapiens_hsa004800.87196712
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82747511
65Retinol metabolism_Homo sapiens_hsa008300.81690000
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81343385
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81310390
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.78885374
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.77776959
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77544308
71Fatty acid metabolism_Homo sapiens_hsa012120.77210590
72Regulation of autophagy_Homo sapiens_hsa041400.75444444
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65014570
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60543843
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60423589
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58932981
77Ether lipid metabolism_Homo sapiens_hsa005650.55266996
78Vitamin digestion and absorption_Homo sapiens_hsa049770.54229763
79Olfactory transduction_Homo sapiens_hsa047400.52975901
80Arginine and proline metabolism_Homo sapiens_hsa003300.50211310
81Taste transduction_Homo sapiens_hsa047420.48648985
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48075718
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47738125
84Circadian rhythm_Homo sapiens_hsa047100.45106069
85Fat digestion and absorption_Homo sapiens_hsa049750.43951927
86Carbon metabolism_Homo sapiens_hsa012000.43666922
87Oocyte meiosis_Homo sapiens_hsa041140.43308884
88GABAergic synapse_Homo sapiens_hsa047270.41180434
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40879935
90Arachidonic acid metabolism_Homo sapiens_hsa005900.39925443
91Hedgehog signaling pathway_Homo sapiens_hsa043400.38290982
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37684988
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36886822
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31079534
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28736083
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.28535261
97Cell cycle_Homo sapiens_hsa041100.28486759
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27979305
99Histidine metabolism_Homo sapiens_hsa003400.25978385
100Tyrosine metabolism_Homo sapiens_hsa003500.25961781

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