C6ORF201

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.05493257
2microtubule depolymerization (GO:0007019)8.30622458
3sperm capacitation (GO:0048240)8.25181757
4chromosome condensation (GO:0030261)8.15321998
5DNA packaging (GO:0006323)8.11894354
6single strand break repair (GO:0000012)7.86386064
7spermatid development (GO:0007286)7.80920154
8protein polyglutamylation (GO:0018095)7.40995512
9protein targeting to Golgi (GO:0000042)7.32875317
10microtubule polymerization or depolymerization (GO:0031109)7.27236413
11establishment of protein localization to Golgi (GO:0072600)7.16922968
12spermatid nucleus differentiation (GO:0007289)6.98053874
13plasma membrane fusion (GO:0045026)6.87775226
14rRNA methylation (GO:0031167)6.74074103
15retrograde transport, vesicle recycling within Golgi (GO:0000301)6.73195542
16regulation of cilium movement (GO:0003352)6.71177227
17sperm-egg recognition (GO:0035036)6.53726211
18negative regulation of inclusion body assembly (GO:0090084)6.51862719
19centriole replication (GO:0007099)6.41467077
20response to pheromone (GO:0019236)6.28969391
21phosphatidylethanolamine biosynthetic process (GO:0006646)6.13356716
22multicellular organism reproduction (GO:0032504)6.07836111
23spermatogenesis (GO:0007283)6.03361870
24male gamete generation (GO:0048232)6.01677997
25binding of sperm to zona pellucida (GO:0007339)5.93329353
26axonemal dynein complex assembly (GO:0070286)5.93165521
27cilium or flagellum-dependent cell motility (GO:0001539)5.78330467
28phosphatidylethanolamine metabolic process (GO:0046337)5.70334648
29regulation of centriole replication (GO:0046599)5.68915159
30microtubule severing (GO:0051013)5.67191628
31reproduction (GO:0000003)5.58688656
32gamete generation (GO:0007276)5.57573974
33centriole assembly (GO:0098534)5.52265909
34rRNA modification (GO:0000154)5.51968000
35calcium ion-dependent exocytosis (GO:0017156)5.37877686
36seminiferous tubule development (GO:0072520)5.35435021
37protein localization to Golgi apparatus (GO:0034067)5.34259325
38cell-cell recognition (GO:0009988)5.30023486
39epithelial cilium movement (GO:0003351)5.08657927
40sexual reproduction (GO:0019953)5.07778549
41RNA destabilization (GO:0050779)4.96679747
42motile cilium assembly (GO:0044458)4.91409866
43germ cell development (GO:0007281)4.60592334
44single fertilization (GO:0007338)4.60305868
45cilium movement (GO:0003341)4.58671535
46piRNA metabolic process (GO:0034587)4.55081144
47regulation of inclusion body assembly (GO:0090083)4.53000226
48regulation of microtubule-based movement (GO:0060632)4.52333105
49multicellular organismal reproductive process (GO:0048609)4.43203165
50fertilization (GO:0009566)4.42007861
51cellular ketone body metabolic process (GO:0046950)4.35928885
52cellular process involved in reproduction in multicellular organism (GO:0022412)4.32943841
53nucleus organization (GO:0006997)4.21643417
54DNA methylation involved in gamete generation (GO:0043046)4.16163895
55regulation of Rab GTPase activity (GO:0032313)4.06649168
56positive regulation of Rab GTPase activity (GO:0032851)4.06649168
57cell wall macromolecule catabolic process (GO:0016998)4.02011027
58ketone body metabolic process (GO:1902224)3.89162994
59microtubule nucleation (GO:0007020)3.82242210
60cell wall macromolecule metabolic process (GO:0044036)3.80365576
61male meiosis (GO:0007140)3.80059163
62male meiosis I (GO:0007141)3.79337732
63nuclear pore complex assembly (GO:0051292)3.77010512
64axoneme assembly (GO:0035082)3.66009601
65regulation of transcription involved in cell fate commitment (GO:0060850)3.53549955
66chromatin silencing (GO:0006342)3.40939462
67glomerular visceral epithelial cell development (GO:0072015)3.34859196
68epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.31703312
69multicellular organismal movement (GO:0050879)3.28043399
70musculoskeletal movement (GO:0050881)3.28043399
71glomerular epithelial cell development (GO:0072310)3.16065469
72organic cation transport (GO:0015695)3.15821056
73negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.15347518
74ventricular system development (GO:0021591)3.11566462
75mitochondrial fission (GO:0000266)3.08429397
76protein-DNA complex disassembly (GO:0032986)3.02942376
77nucleosome disassembly (GO:0006337)3.02942376
78histone exchange (GO:0043486)2.99943671
79microtubule bundle formation (GO:0001578)2.99563128
80cerebral cortex neuron differentiation (GO:0021895)2.96846901
81multicellular organismal development (GO:0007275)2.96556730
82RNA localization (GO:0006403)2.96531877
83cilium organization (GO:0044782)2.96238906
84intra-Golgi vesicle-mediated transport (GO:0006891)2.95257818
85protein depolymerization (GO:0051261)2.94738456
86meiosis I (GO:0007127)2.94396102
87centrosome duplication (GO:0051298)2.93707582
88glycerol ether metabolic process (GO:0006662)2.92739272
89cilium assembly (GO:0042384)2.92166222
90regulation of meiosis I (GO:0060631)2.90555587
91chromosome organization involved in meiosis (GO:0070192)2.87306023
92Golgi to endosome transport (GO:0006895)2.86088840
93nuclear pore organization (GO:0006999)2.85626554
94genitalia morphogenesis (GO:0035112)2.83567781
95DNA conformation change (GO:0071103)2.83467688
96homeostasis of number of cells within a tissue (GO:0048873)2.82549645
97synaptonemal complex assembly (GO:0007130)2.81381897
98polyamine biosynthetic process (GO:0006596)2.81016179
99sperm motility (GO:0030317)11.2601689
100acrosome reaction (GO:0007340)10.3299895

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.57806900
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.11082253
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.02489768
4FUS_26573619_Chip-Seq_HEK293_Human2.81763634
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.74156195
6TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.54056344
7POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.54056344
8CBP_20019798_ChIP-Seq_JUKART_Human2.53248943
9IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.53248943
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.52246403
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.51191934
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.44725883
13EZH2_22144423_ChIP-Seq_EOC_Human2.19192916
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.14951475
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.13732422
16ZNF274_21170338_ChIP-Seq_K562_Hela2.10906274
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.10218427
18UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human2.03160952
19P300_19829295_ChIP-Seq_ESCs_Human1.99883682
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97006892
21ER_23166858_ChIP-Seq_MCF-7_Human1.96522909
22SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.89645432
23VDR_22108803_ChIP-Seq_LS180_Human1.74876932
24SMAD4_21741376_ChIP-Seq_EPCs_Human1.73343015
25AR_25329375_ChIP-Seq_VCAP_Human1.72430594
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67555186
27STAT3_23295773_ChIP-Seq_U87_Human1.67448778
28SMAD4_21799915_ChIP-Seq_A2780_Human1.66419221
29GBX2_23144817_ChIP-Seq_PC3_Human1.64216850
30TAF15_26573619_Chip-Seq_HEK293_Human1.63541571
31SMAD3_21741376_ChIP-Seq_EPCs_Human1.62327872
32ARNT_22903824_ChIP-Seq_MCF-7_Human1.60668612
33WDR5_24793694_ChIP-Seq_LNCAP_Human1.60060279
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55184986
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53848636
36TP53_18474530_ChIP-ChIP_U2OS_Human1.50957955
37TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49973879
38AUTS2_25519132_ChIP-Seq_293T-REX_Human1.48785071
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.47386702
40CBX2_22325352_ChIP-Seq_293T-Rex_Human1.47333995
41ETV1_20927104_ChIP-Seq_GIST48_Human1.46890585
42* ERA_21632823_ChIP-Seq_H3396_Human1.46185887
43RBPJ_21746931_ChIP-Seq_IB4_Human1.43239163
44HNFA_21074721_ChIP-Seq_CACO-2_Human1.41945138
45DROSHA_22980978_ChIP-Seq_HELA_Human1.41810434
46MYC_19829295_ChIP-Seq_ESCs_Human1.41203671
47RUNX2_22187159_ChIP-Seq_PCA_Human1.41017184
48VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.39917959
49CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.39767755
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38863273
51NANOG_19829295_ChIP-Seq_ESCs_Human1.36736092
52SOX2_19829295_ChIP-Seq_ESCs_Human1.36736092
53KLF5_20875108_ChIP-Seq_MESCs_Mouse1.35181201
54* NANOG_20526341_ChIP-Seq_ESCs_Human1.34967616
55TBL1_22424771_ChIP-Seq_293T_Human1.34680324
56SMAD3_21741376_ChIP-Seq_ESCs_Human1.33482262
57NFYB_21822215_ChIP-Seq_K562_Human1.33304908
58EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.32883799
59ERG_20517297_ChIP-Seq_VCAP_Human1.32664858
60AR_21572438_ChIP-Seq_LNCaP_Human1.26814378
61PHF8_20622853_ChIP-Seq_HELA_Human1.26761732
62PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.25112575
63FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24720772
64OCT4_20526341_ChIP-Seq_ESCs_Human1.23138521
65* RAC3_21632823_ChIP-Seq_H3396_Human1.22443371
66TCF4_23295773_ChIP-Seq_U87_Human1.22325458
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21955187
68RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.21954303
69TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21034984
70TDRD3_21172665_ChIP-Seq_MCF-7_Human1.19893034
71* TAF2_19829295_ChIP-Seq_ESCs_Human1.18414423
72ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18214064
73CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.17757324
74EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.17539979
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15137115
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.14745111
77CEBPB_22108803_ChIP-Seq_LS180_Human1.14678969
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14272976
79NFYA_21822215_ChIP-Seq_K562_Human1.14123566
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13886809
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12486806
82GATA6_21074721_ChIP-Seq_CACO-2_Human1.10497540
83GATA3_21878914_ChIP-Seq_MCF-7_Human1.08852806
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08048017
85TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.05537515
86SALL4_22934838_ChIP-ChIP_CD34+_Human1.05187676
87SMAD4_21741376_ChIP-Seq_HESCs_Human1.04415869
88KDM2B_26808549_Chip-Seq_REH_Human1.04079377
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03220825
90FOXA1_25329375_ChIP-Seq_VCAP_Human1.02350864
91FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02350864
92CTCF_27219007_Chip-Seq_Bcells_Human1.02335008
93HOXB7_26014856_ChIP-Seq_BT474_Human1.01906519
94CJUN_26792858_Chip-Seq_BT549_Human1.00982067
95ELF1_20517297_ChIP-Seq_JURKAT_Human1.00939008
96GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00884103
97KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.00177889
98NANOG_18555785_Chip-Seq_ESCs_Mouse0.99110758
99TCF4_18268006_ChIP-ChIP_LS174T_Human0.99013163
100PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.98762788

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.45694487
2MP0003878_abnormal_ear_physiology4.36445495
3MP0005377_hearing/vestibular/ear_phenot4.36445495
4MP0001929_abnormal_gametogenesis4.18987992
5MP0005670_abnormal_white_adipose3.96032555
6MP0008877_abnormal_DNA_methylation2.88842279
7MP0003646_muscle_fatigue2.79553592
8MP0003718_maternal_effect2.60072009
9MP0002161_abnormal_fertility/fecundity2.48855212
10MP0002210_abnormal_sex_determination2.35174276
11MP0001348_abnormal_lacrimal_gland2.03512310
12MP0005410_abnormal_fertilization10.8098609
13MP0001145_abnormal_male_reproductive1.87341760
14MP0001485_abnormal_pinna_reflex1.82956922
15MP0000653_abnormal_sex_gland1.82130819
16MP0001486_abnormal_startle_reflex1.76866892
17MP0002282_abnormal_trachea_morphology1.67960992
18MP0002132_abnormal_respiratory_system1.65139809
19MP0005551_abnormal_eye_electrophysiolog1.57999547
20MP0005253_abnormal_eye_physiology1.52735957
21MP0003011_delayed_dark_adaptation1.50976954
22MP0005379_endocrine/exocrine_gland_phen1.49722723
23MP0005423_abnormal_somatic_nervous1.40896529
24MP0005310_abnormal_salivary_gland1.40562853
25MP0008789_abnormal_olfactory_epithelium1.36896577
26MP0008995_early_reproductive_senescence1.31347585
27MP0005395_other_phenotype1.30227876
28MP0000534_abnormal_ureter_morphology1.24773536
29MP0002735_abnormal_chemical_nociception1.23938850
30MP0002234_abnormal_pharynx_morphology1.23061163
31MP0001963_abnormal_hearing_physiology1.18619771
32MP0002127_abnormal_cardiovascular_syste1.17026984
33MP0009053_abnormal_anal_canal1.15641809
34MP0005248_abnormal_Harderian_gland1.14077243
35MP0004742_abnormal_vestibular_system1.13705784
36MP0000516_abnormal_urinary_system1.09916125
37MP0005367_renal/urinary_system_phenotyp1.09916125
38MP0005451_abnormal_body_composition1.09873857
39MP0000678_abnormal_parathyroid_gland1.07573301
40MP0002928_abnormal_bile_duct1.05708045
41MP0001968_abnormal_touch/_nociception1.03667057
42MP0002138_abnormal_hepatobiliary_system1.03107099
43MP0006292_abnormal_olfactory_placode1.00921239
44MP0001984_abnormal_olfaction0.98280110
45MP0000026_abnormal_inner_ear0.98032786
46MP0003077_abnormal_cell_cycle0.94573787
47MP0003787_abnormal_imprinting0.92737116
48MP0008058_abnormal_DNA_repair0.92473956
49MP0002229_neurodegeneration0.91815360
50MP0000955_abnormal_spinal_cord0.89344300
51MP0005394_taste/olfaction_phenotype0.88749515
52MP0005499_abnormal_olfactory_system0.88749515
53MP0002249_abnormal_larynx_morphology0.88603094
54MP0009697_abnormal_copulation0.86695728
55MP0009115_abnormal_fat_cell0.86404181
56MP0000049_abnormal_middle_ear0.86196581
57MP0001270_distended_abdomen0.83549445
58MP0002822_catalepsy0.82648477
59MP0005083_abnormal_biliary_tract0.81016913
60MP0005084_abnormal_gallbladder_morpholo0.79044715
61MP0002557_abnormal_social/conspecific_i0.77541651
62MP0005391_vision/eye_phenotype0.75968855
63MP0010329_abnormal_lipoprotein_level0.74084027
64MP0001765_abnormal_ion_homeostasis0.73846027
65MP0001666_abnormal_nutrient_absorption0.69265203
66MP0002067_abnormal_sensory_capabilities0.68239219
67MP0010386_abnormal_urinary_bladder0.67775619
68MP0003880_abnormal_central_pattern0.67459032
69MP0003136_yellow_coat_color0.64855194
70MP0003879_abnormal_hair_cell0.64016331
71MP0004085_abnormal_heartbeat0.62661714
72MP0000613_abnormal_salivary_gland0.58177869
73MP0001119_abnormal_female_reproductive0.57217141
74MP0006276_abnormal_autonomic_nervous0.55693584
75MP0003699_abnormal_female_reproductive0.55647539
76MP0003119_abnormal_digestive_system0.54937649
77MP0010094_abnormal_chromosome_stability0.53174483
78MP0004957_abnormal_blastocyst_morpholog0.52474686
79MP0008569_lethality_at_weaning0.52101868
80MP0003950_abnormal_plasma_membrane0.51588082
81MP0003861_abnormal_nervous_system0.50954839
82MP0004859_abnormal_synaptic_plasticity0.48759927
83MP0003385_abnormal_body_wall0.48733054
84MP0002168_other_aberrant_phenotype0.48664070
85MP0005666_abnormal_adipose_tissue0.46066601
86MP0002572_abnormal_emotion/affect_behav0.46063483
87MP0004036_abnormal_muscle_relaxation0.45055014
88MP0004043_abnormal_pH_regulation0.44276492
89MP0005195_abnormal_posterior_eye0.43839749
90MP0009745_abnormal_behavioral_response0.43705133
91MP0002752_abnormal_somatic_nervous0.43460409
92MP0002272_abnormal_nervous_system0.43393029
93MP0004484_altered_response_of0.42308128
94MP0005623_abnormal_meninges_morphology0.42114622
95MP0005636_abnormal_mineral_homeostasis0.41587217
96MP0002734_abnormal_mechanical_nocicepti0.41412747
97MP0003935_abnormal_craniofacial_develop0.41340184
98MP0001299_abnormal_eye_distance/0.39910084
99MP0000778_abnormal_nervous_system0.38967398
100MP0003755_abnormal_palate_morphology0.38902818

Predicted human phenotypes

RankGene SetZ-score
1Tubulointerstitial nephritis (HP:0001970)7.47581903
2Chronic hepatic failure (HP:0100626)7.13483358
3Absent/shortened dynein arms (HP:0200106)6.06573698
4Dynein arm defect of respiratory motile cilia (HP:0012255)6.06573698
5Severe visual impairment (HP:0001141)5.74171272
6Abnormal ciliary motility (HP:0012262)4.64969454
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.47093945
8Abnormal respiratory motile cilium physiology (HP:0012261)4.44517400
9Hypoalphalipoproteinemia (HP:0003233)4.28475398
10Male infertility (HP:0003251)4.24867427
11Bony spicule pigmentary retinopathy (HP:0007737)4.23376745
12Abnormal respiratory epithelium morphology (HP:0012253)4.22705367
13Abnormal respiratory motile cilium morphology (HP:0005938)4.22705367
14Cone-rod dystrophy (HP:0000548)4.13550578
15Attenuation of retinal blood vessels (HP:0007843)4.01900423
16Hyperkalemia (HP:0002153)3.79418175
17Asymmetric septal hypertrophy (HP:0001670)3.68980444
18Nephronophthisis (HP:0000090)3.52874403
19Abnormality of macular pigmentation (HP:0008002)3.51403957
20Infertility (HP:0000789)3.48277861
21Tubulointerstitial abnormality (HP:0001969)3.47838990
22Aplasia/Hypoplasia of the earlobes (HP:0009906)3.38270616
23Truncal obesity (HP:0001956)3.36993403
24Hypoplasia of the thymus (HP:0000778)3.28252157
25Nasal polyposis (HP:0100582)3.24825955
26Resting tremor (HP:0002322)3.21247296
27Bell-shaped thorax (HP:0001591)3.19621559
28Menstrual irregularities (HP:0000858)3.17283675
29Abnormality of the renal medulla (HP:0100957)3.13718660
30Abnormal rod and cone electroretinograms (HP:0008323)3.12509754
31Stage 5 chronic kidney disease (HP:0003774)3.07317948
32Abnormal spermatogenesis (HP:0008669)3.03624512
33Azoospermia (HP:0000027)2.99285255
34Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.97836124
35Progressive sensorineural hearing impairment (HP:0000408)2.97674624
36Impulsivity (HP:0100710)2.92088135
37Rhinitis (HP:0012384)2.84323660
38Potter facies (HP:0002009)2.73639583
39Facial shape deformation (HP:0011334)2.73639583
40Portal hypertension (HP:0001409)2.66493428
41Volvulus (HP:0002580)2.63214766
42Progressive cerebellar ataxia (HP:0002073)2.61161062
43Intellectual disability, moderate (HP:0002342)2.58211744
44Renovascular hypertension (HP:0100817)2.50841592
45True hermaphroditism (HP:0010459)2.49748112
46Insulin-resistant diabetes mellitus (HP:0000831)2.49020003
47Abnormality of the hepatic vasculature (HP:0006707)2.46037524
48Postural instability (HP:0002172)2.44812817
49Hypolipoproteinemia (HP:0010981)2.44592838
50Abnormality of the nasal mucosa (HP:0000433)2.44491329
51Hypoplastic ischia (HP:0003175)2.43665541
52Abnormality of the ischium (HP:0003174)2.43644362
53Amelogenesis imperfecta (HP:0000705)2.38139629
54Hyperuricemia (HP:0002149)2.37726240
55Increased purine levels (HP:0004368)2.37726240
56Occipital encephalocele (HP:0002085)2.34848868
57Abnormality of dental color (HP:0011073)2.30055038
58Enlarged epiphyses (HP:0010580)2.26380059
59Pancreatic fibrosis (HP:0100732)2.20346523
60Chronic bronchitis (HP:0004469)2.16897794
61Tubular atrophy (HP:0000092)2.16787787
62Abnormal urine output (HP:0012590)2.16611094
63Osteomalacia (HP:0002749)2.14767319
64Polydipsia (HP:0001959)2.09353788
65Abnormal drinking behavior (HP:0030082)2.09353788
66Bronchiectasis (HP:0002110)2.08593487
67Abnormality of potassium homeostasis (HP:0011042)2.00591260
68Optic nerve hypoplasia (HP:0000609)1.96908215
69Pancreatic cysts (HP:0001737)1.91957884
70Subcapsular cataract (HP:0000523)1.90576368
71Abnormality of renal excretion (HP:0011036)1.89385543
72Obsessive-compulsive behavior (HP:0000722)1.89361266
73Decreased central vision (HP:0007663)1.87086917
74Renal dysplasia (HP:0000110)1.84606063
75Progressive hearing impairment (HP:0001730)1.83534450
76Polyuria (HP:0000103)1.82441762
77Focal segmental glomerulosclerosis (HP:0000097)1.77103990
78Hypophosphatemic rickets (HP:0004912)1.76914440
79Sandal gap (HP:0001852)1.76516151
80Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.74805953
81Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.72741780
82Horizontal nystagmus (HP:0000666)1.71007955
83Generalized aminoaciduria (HP:0002909)1.70603654
84Abnormality of the renal cortex (HP:0011035)1.70484054
85Median cleft lip (HP:0000161)1.69001035
86Molar tooth sign on MRI (HP:0002419)1.68495837
87Abnormality of midbrain morphology (HP:0002418)1.68495837
88Abnormality of the costochondral junction (HP:0000919)1.68086453
89Photophobia (HP:0000613)1.67200406
90Sex reversal (HP:0012245)1.67150686
91Abnormal sex determination (HP:0012244)1.67150686
92Gonadal dysgenesis (HP:0000133)1.66030563
93Transposition of the great arteries (HP:0001669)1.65088691
94Abnormal connection of the cardiac segments (HP:0011545)1.65088691
95Abnormal ventriculo-arterial connection (HP:0011563)1.65088691
96Duodenal stenosis (HP:0100867)1.64332159
97Small intestinal stenosis (HP:0012848)1.64332159
98Congenital sensorineural hearing impairment (HP:0008527)1.64289463
99Renal Fanconi syndrome (HP:0001994)1.63268728
100Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63199791

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.45734935
2BRD44.44099826
3PNCK3.92351767
4INSRR3.36469006
5PLK23.35579492
6TESK13.00582502
7STK382.67008527
8STK38L2.54279563
9MAP4K22.53956421
10DDR22.44521354
11CAMK1G2.42980066
12MAPK152.24511125
13PRKD32.06947628
14BMPR1B1.89852713
15AKT31.74291362
16WNK31.71345623
17PIK3CG1.68699062
18LMTK21.67514230
19NEK61.57256633
20STK391.52854261
21ACVR1B1.44012761
22BRSK21.43973226
23FRK1.22525575
24DYRK1B1.16457924
25PINK10.99881741
26TNIK0.99221400
27PTK2B0.98911389
28PDK10.96021257
29WNK10.94158308
30MARK10.92755490
31TYRO30.90181866
32MKNK20.87632407
33PDPK10.84210045
34MUSK0.83610862
35CAMK1D0.81533644
36WNK40.81436930
37MST1R0.81270821
38OXSR10.80875292
39MAP3K40.78178824
40CDK120.73717565
41BRSK10.73013540
42CDK70.70457810
43NTRK20.67827541
44CASK0.66082964
45CDK30.64590647
46PDK20.63927409
47TIE10.63784096
48PBK0.61967091
49PRKG10.60034589
50ROCK10.59971394
51DYRK30.58991185
52SGK4940.58703322
53SGK2230.58703322
54PKN10.56901068
55CCNB10.55530580
56MAPK130.55306225
57PLK10.52062960
58KSR20.51867830
59PRKG20.51860931
60NTRK30.50948234
61NUAK10.50152091
62SGK20.46666930
63MARK30.46270472
64CHEK10.44429337
65CDK10.44286639
66BRAF0.43810427
67TGFBR10.43791273
68CDK20.43568526
69SIK20.42302287
70CAMK10.42130025
71SGK10.40729543
72WEE10.40497114
73GSK3B0.38818550
74EIF2AK30.38382811
75MAP3K20.37699820
76PRKAA20.35723106
77NEK20.34809956
78RIPK10.34544520
79PLK30.34528706
80RPS6KA10.34514426
81MAPK10.34111601
82LATS10.32995758
83MINK10.30485707
84PRKCE0.30415976
85MAP2K70.30344444
86TSSK60.29493005
87ATM0.29473169
88TTK0.28965844
89MKNK10.28420054
90MAP3K80.27367432
91DYRK1A0.26415184
92PRKCG0.26131385
93ZAK0.25235243
94MAPK80.24841134
95MAPK140.24135807
96RPS6KA20.23452738
97VRK10.21687936
98UHMK10.20993618
99PRKCB0.20795850
100CAMK40.18824828

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.00058360
2Fatty acid biosynthesis_Homo sapiens_hsa000616.30017375
3Olfactory transduction_Homo sapiens_hsa047403.24201493
4Butanoate metabolism_Homo sapiens_hsa006503.09439077
5Fatty acid degradation_Homo sapiens_hsa000712.31425460
6RNA transport_Homo sapiens_hsa030132.21944503
7Dorso-ventral axis formation_Homo sapiens_hsa043202.21593795
8Fanconi anemia pathway_Homo sapiens_hsa034602.15980981
9Fatty acid metabolism_Homo sapiens_hsa012121.87972649
10Glycerophospholipid metabolism_Homo sapiens_hsa005641.81530028
11ABC transporters_Homo sapiens_hsa020101.67406830
12Primary bile acid biosynthesis_Homo sapiens_hsa001201.65215632
13Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.65144246
14Phototransduction_Homo sapiens_hsa047441.49231705
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48072488
16Hedgehog signaling pathway_Homo sapiens_hsa043401.45161809
17Taste transduction_Homo sapiens_hsa047421.44071629
18Propanoate metabolism_Homo sapiens_hsa006401.33261877
19Circadian rhythm_Homo sapiens_hsa047101.31574527
20Oocyte meiosis_Homo sapiens_hsa041141.25659252
21Basal transcription factors_Homo sapiens_hsa030221.24668975
22Non-homologous end-joining_Homo sapiens_hsa034501.15351191
23Lysine degradation_Homo sapiens_hsa003101.13045307
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10155269
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06854768
26Retinol metabolism_Homo sapiens_hsa008301.05560552
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.05253651
28Arginine and proline metabolism_Homo sapiens_hsa003301.03157408
29PPAR signaling pathway_Homo sapiens_hsa033201.02869038
30Glycerolipid metabolism_Homo sapiens_hsa005611.01668118
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01312073
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00660497
33Phenylalanine metabolism_Homo sapiens_hsa003600.91656486
34Fat digestion and absorption_Homo sapiens_hsa049750.87026063
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87011272
36Type II diabetes mellitus_Homo sapiens_hsa049300.82482667
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82370417
38Inositol phosphate metabolism_Homo sapiens_hsa005620.82139660
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79031597
40Homologous recombination_Homo sapiens_hsa034400.77344468
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75722569
42Selenocompound metabolism_Homo sapiens_hsa004500.75675655
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75387973
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74146636
45Calcium signaling pathway_Homo sapiens_hsa040200.72926273
46Salivary secretion_Homo sapiens_hsa049700.70778395
47One carbon pool by folate_Homo sapiens_hsa006700.70390561
48Peroxisome_Homo sapiens_hsa041460.68841979
49Protein digestion and absorption_Homo sapiens_hsa049740.68718744
50Chemical carcinogenesis_Homo sapiens_hsa052040.67179941
51Nicotine addiction_Homo sapiens_hsa050330.66650407
52cAMP signaling pathway_Homo sapiens_hsa040240.66093815
53Morphine addiction_Homo sapiens_hsa050320.61829978
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60064731
55Adipocytokine signaling pathway_Homo sapiens_hsa049200.59956529
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56718851
57mRNA surveillance pathway_Homo sapiens_hsa030150.55259827
58Arginine biosynthesis_Homo sapiens_hsa002200.53963100
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53885319
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53716847
61Pancreatic secretion_Homo sapiens_hsa049720.53475193
62Tight junction_Homo sapiens_hsa045300.53201102
63Circadian entrainment_Homo sapiens_hsa047130.53181336
64beta-Alanine metabolism_Homo sapiens_hsa004100.52622098
65Endocytosis_Homo sapiens_hsa041440.51762890
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48855555
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.48526382
68Cell cycle_Homo sapiens_hsa041100.47463663
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.47258961
70Tyrosine metabolism_Homo sapiens_hsa003500.47170035
71Glutamatergic synapse_Homo sapiens_hsa047240.46715425
72Linoleic acid metabolism_Homo sapiens_hsa005910.46433588
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45963590
74Nitrogen metabolism_Homo sapiens_hsa009100.45730880
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45243831
76Biosynthesis of amino acids_Homo sapiens_hsa012300.45091291
77Base excision repair_Homo sapiens_hsa034100.44662690
78Purine metabolism_Homo sapiens_hsa002300.41660736
79Adherens junction_Homo sapiens_hsa045200.40077110
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39050015
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38865851
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37559254
83Estrogen signaling pathway_Homo sapiens_hsa049150.37098797
84Huntingtons disease_Homo sapiens_hsa050160.36595699
85Bile secretion_Homo sapiens_hsa049760.36282159
86Serotonergic synapse_Homo sapiens_hsa047260.35463790
87Tryptophan metabolism_Homo sapiens_hsa003800.34577440
88Regulation of autophagy_Homo sapiens_hsa041400.34163286
89Carbon metabolism_Homo sapiens_hsa012000.33396108
90Metabolic pathways_Homo sapiens_hsa011000.33339309
91Vitamin B6 metabolism_Homo sapiens_hsa007500.32274543
92TGF-beta signaling pathway_Homo sapiens_hsa043500.28885041
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28755055
94Gastric acid secretion_Homo sapiens_hsa049710.28338010
95Antigen processing and presentation_Homo sapiens_hsa046120.26621964
96Influenza A_Homo sapiens_hsa051640.26332864
97Renin secretion_Homo sapiens_hsa049240.25962121
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.24765305
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23863406
100Thyroid hormone synthesis_Homo sapiens_hsa049180.22975562

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