C6ORF118

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)9.28829138
2left/right pattern formation (GO:0060972)7.82888811
3intraciliary transport (GO:0042073)7.71427694
4regulation of cilium movement (GO:0003352)7.26593960
5cilium organization (GO:0044782)6.67769752
6cilium assembly (GO:0042384)6.51929181
7ventricular system development (GO:0021591)6.40115590
8left/right axis specification (GO:0070986)6.01346253
9microtubule bundle formation (GO:0001578)5.61674193
10cilium morphogenesis (GO:0060271)5.47972525
11protein localization to cilium (GO:0061512)5.17296490
12cellular component assembly involved in morphogenesis (GO:0010927)5.06686160
13microtubule-based movement (GO:0007018)4.49965429
14centriole assembly (GO:0098534)4.47217751
15regulation of microtubule-based movement (GO:0060632)4.42527849
16cell projection assembly (GO:0030031)4.37306915
17microtubule depolymerization (GO:0007019)4.24187473
18smoothened signaling pathway (GO:0007224)4.19745920
19nonmotile primary cilium assembly (GO:0035058)4.12980964
20centriole replication (GO:0007099)4.05563632
21primary alcohol catabolic process (GO:0034310)3.85695257
22determination of left/right symmetry (GO:0007368)3.80757758
23nucleoside diphosphate phosphorylation (GO:0006165)3.80107428
24determination of bilateral symmetry (GO:0009855)3.74225184
25lateral sprouting from an epithelium (GO:0060601)3.70764548
26specification of symmetry (GO:0009799)3.65031788
27microtubule polymerization or depolymerization (GO:0031109)3.56971513
28establishment of planar polarity (GO:0001736)3.55506973
29establishment of tissue polarity (GO:0007164)3.55506973
30vitamin transmembrane transport (GO:0035461)3.30637232
31lateral ventricle development (GO:0021670)3.30069374
32retinal rod cell development (GO:0046548)3.25537660
33lung epithelium development (GO:0060428)3.16684205
34response to xenobiotic stimulus (GO:0009410)3.16372670
35ethanol metabolic process (GO:0006067)3.08769308
36limb development (GO:0060173)3.08024660
37appendage development (GO:0048736)3.08024660
38sperm motility (GO:0030317)3.04396714
39protein polyglutamylation (GO:0018095)3.00973222
40photoreceptor cell maintenance (GO:0045494)2.99854877
41organelle assembly (GO:0070925)2.94376028
42neuronal stem cell maintenance (GO:0097150)2.91883527
43regulation of collateral sprouting (GO:0048670)2.90136149
44regulation of smoothened signaling pathway (GO:0008589)2.87188802
45positive regulation of smoothened signaling pathway (GO:0045880)2.86810150
46sperm capacitation (GO:0048240)2.84861157
47terpenoid biosynthetic process (GO:0016114)2.80608887
48microtubule-based process (GO:0007017)2.79530509
49diterpenoid biosynthetic process (GO:0016102)2.78351051
50negative regulation of T cell differentiation in thymus (GO:0033085)2.77614856
51carnitine metabolic process (GO:0009437)2.76226818
52pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.75734999
53establishment or maintenance of monopolar cell polarity (GO:0061339)2.75357533
54establishment of monopolar cell polarity (GO:0061162)2.75357533
55intra-S DNA damage checkpoint (GO:0031573)2.74682149
56cytoplasmic microtubule organization (GO:0031122)2.72057180
57dorsal/ventral pattern formation (GO:0009953)2.71548788
58cornea development in camera-type eye (GO:0061303)2.67946658
59tongue development (GO:0043586)2.67913260
60retinal ganglion cell axon guidance (GO:0031290)2.64100218
61heart looping (GO:0001947)2.63353584
62negative regulation of B cell mediated immunity (GO:0002713)2.63032293
63negative regulation of immunoglobulin mediated immune response (GO:0002890)2.63032293
64negative regulation of humoral immune response (GO:0002921)2.62865660
65base-excision repair, AP site formation (GO:0006285)2.61699913
66neural tube formation (GO:0001841)2.60425190
67one-carbon compound transport (GO:0019755)2.58620746
68retinoic acid metabolic process (GO:0042573)2.55171906
69amino-acid betaine metabolic process (GO:0006577)2.54812805
70GTP biosynthetic process (GO:0006183)2.53199334
71neuron fate determination (GO:0048664)2.52421013
72aldehyde catabolic process (GO:0046185)2.50514537
73establishment of apical/basal cell polarity (GO:0035089)2.49613262
74dorsal/ventral neural tube patterning (GO:0021904)2.49010749
75neurotransmitter catabolic process (GO:0042135)2.45794357
76glomerular epithelial cell development (GO:0072310)2.45528295
77embryonic heart tube morphogenesis (GO:0003143)2.43959216
78negative regulation of oligodendrocyte differentiation (GO:0048715)2.43453191
79pyrimidine nucleotide catabolic process (GO:0006244)2.41539546
80somite development (GO:0061053)2.40383915
81pyrimidine-containing compound transmembrane transport (GO:0072531)2.38564176
82limb bud formation (GO:0060174)2.36535939
83spinal cord motor neuron differentiation (GO:0021522)2.34257785
84asymmetric protein localization (GO:0008105)2.33883553
85glutathione derivative metabolic process (GO:1901685)2.32597451
86glutathione derivative biosynthetic process (GO:1901687)2.32597451
87negative regulation of transcription regulatory region DNA binding (GO:2000678)2.32095737
88pyrimidine nucleobase catabolic process (GO:0006208)2.31668661
89nucleotide phosphorylation (GO:0046939)2.30124649
90negative regulation of inclusion body assembly (GO:0090084)2.30106491
91telencephalon development (GO:0021537)2.27652125
92ethanol oxidation (GO:0006069)2.26812079
93eye photoreceptor cell differentiation (GO:0001754)2.26401598
94photoreceptor cell differentiation (GO:0046530)2.26401598
95axonemal dynein complex assembly (GO:0070286)17.2612994
96cilium or flagellum-dependent cell motility (GO:0001539)14.3603764
97cilium movement (GO:0003341)14.1080082
98epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)13.5084650
99epithelial cilium movement (GO:0003351)13.4585957
100motile cilium assembly (GO:0044458)11.8933964

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.88072206
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.34648111
3VDR_22108803_ChIP-Seq_LS180_Human2.78659085
4TAF15_26573619_Chip-Seq_HEK293_Human2.41757640
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.40432775
6CTBP2_25329375_ChIP-Seq_LNCAP_Human2.22774838
7ZNF274_21170338_ChIP-Seq_K562_Hela2.19963297
8PIAS1_25552417_ChIP-Seq_VCAP_Human2.19344385
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.17001900
10FUS_26573619_Chip-Seq_HEK293_Human2.13916026
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.02645198
12POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98656552
13GBX2_23144817_ChIP-Seq_PC3_Human1.96705566
14EWS_26573619_Chip-Seq_HEK293_Human1.95920364
15IGF1R_20145208_ChIP-Seq_DFB_Human1.95580671
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95000175
17DROSHA_22980978_ChIP-Seq_HELA_Human1.92029227
18NR3C1_21868756_ChIP-Seq_MCF10A_Human1.90206564
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88624252
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87629248
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85981115
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.84264640
23TOP2B_26459242_ChIP-Seq_MCF-7_Human1.79771220
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.75032259
25P300_19829295_ChIP-Seq_ESCs_Human1.70491416
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70319884
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.70108165
28CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69475897
29SMAD4_21799915_ChIP-Seq_A2780_Human1.64567816
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.64355672
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.61946670
32FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.61930336
33RNF2_27304074_Chip-Seq_NSC_Mouse1.57826498
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57234669
35SMAD3_21741376_ChIP-Seq_EPCs_Human1.49811359
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44037652
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44037652
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41152986
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40485629
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37524119
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37514885
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37255569
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37035332
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34899291
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.34606257
46TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32595832
47AR_21572438_ChIP-Seq_LNCaP_Human1.31693952
48STAT3_23295773_ChIP-Seq_U87_Human1.27910067
49FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27507076
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26951978
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.26188490
52TP53_18474530_ChIP-ChIP_U2OS_Human1.25448172
53SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.24580175
54* TCF4_22108803_ChIP-Seq_LS180_Human1.23794713
55CBP_20019798_ChIP-Seq_JUKART_Human1.22732103
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22732103
57* RUNX2_22187159_ChIP-Seq_PCA_Human1.22069639
58STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21577423
59ER_23166858_ChIP-Seq_MCF-7_Human1.19236214
60AHR_22903824_ChIP-Seq_MCF-7_Human1.18363246
61BCAT_22108803_ChIP-Seq_LS180_Human1.15533291
62KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15388457
63HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14724740
64WDR5_24793694_ChIP-Seq_LNCAP_Human1.14573771
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14054056
66* AR_25329375_ChIP-Seq_VCAP_Human1.13769917
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12874448
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.12305870
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11816897
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.09239457
71EZH2_27304074_Chip-Seq_ESCs_Mouse1.08496809
72TCF4_23295773_ChIP-Seq_U87_Human1.07724064
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07165677
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07070729
75TBL1_22424771_ChIP-Seq_293T_Human1.06117135
76SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05560776
77IRF1_19129219_ChIP-ChIP_H3396_Human1.05375766
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04781762
79TAL1_26923725_Chip-Seq_HPCs_Mouse1.04457699
80PHF8_20622853_ChIP-Seq_HELA_Human1.03933404
81TP53_16413492_ChIP-PET_HCT116_Human1.03233987
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02493259
83RNF2_27304074_Chip-Seq_ESCs_Mouse1.02208876
84NFYA_21822215_ChIP-Seq_K562_Human1.00465109
85GATA1_26923725_Chip-Seq_HPCs_Mouse1.00222215
86REST_21632747_ChIP-Seq_MESCs_Mouse1.00024644
87P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98826988
88JUN_21703547_ChIP-Seq_K562_Human0.98783205
89KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98014313
90ETV1_20927104_ChIP-Seq_GIST48_Human0.97935899
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97923853
92STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97394683
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97220395
94SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97043472
95AR_19668381_ChIP-Seq_PC3_Human0.96896801
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95808743
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94690316
98EED_16625203_ChIP-ChIP_MESCs_Mouse0.94108259
99NFYB_21822215_ChIP-Seq_K562_Human0.93648350
100TRIM28_21343339_ChIP-Seq_HEK293_Human0.93472668

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology5.89867314
2MP0003136_yellow_coat_color4.02099606
3MP0000566_synostosis3.82155823
4MP0004133_heterotaxia3.43852162
5MP0008789_abnormal_olfactory_epithelium3.42999282
6MP0001984_abnormal_olfaction3.19287011
7MP0008875_abnormal_xenobiotic_pharmacok3.10763551
8MP0005394_taste/olfaction_phenotype2.70616767
9MP0005499_abnormal_olfactory_system2.70616767
10MP0010030_abnormal_orbit_morphology2.35713449
11MP0002282_abnormal_trachea_morphology2.33476262
12MP0005377_hearing/vestibular/ear_phenot2.16752193
13MP0003878_abnormal_ear_physiology2.16752193
14MP0006292_abnormal_olfactory_placode2.15696476
15MP0002132_abnormal_respiratory_system2.12685827
16MP0005248_abnormal_Harderian_gland2.10965079
17MP0001293_anophthalmia1.90826300
18MP0003122_maternal_imprinting1.87558296
19MP0000383_abnormal_hair_follicle1.76996268
20MP0000778_abnormal_nervous_system1.76068916
21MP0005623_abnormal_meninges_morphology1.75627276
22MP0002277_abnormal_respiratory_mucosa1.65918544
23MP0003937_abnormal_limbs/digits/tail_de1.65409070
24MP0002638_abnormal_pupillary_reflex1.65238209
25MP0000049_abnormal_middle_ear1.64361513
26MP0006072_abnormal_retinal_apoptosis1.63901786
27MP0005253_abnormal_eye_physiology1.63366924
28MP0000631_abnormal_neuroendocrine_gland1.63232271
29MP0003880_abnormal_central_pattern1.59513123
30MP0002233_abnormal_nose_morphology1.57989683
31MP0000026_abnormal_inner_ear1.56563874
32MP0004043_abnormal_pH_regulation1.43357061
33MP0005187_abnormal_penis_morphology1.41028748
34MP0001485_abnormal_pinna_reflex1.39343653
35MP0002938_white_spotting1.37018414
36MP0002822_catalepsy1.36574735
37MP0001529_abnormal_vocalization1.35776727
38MP0002249_abnormal_larynx_morphology1.34008961
39MP0002928_abnormal_bile_duct1.30915667
40MP0008995_early_reproductive_senescence1.29678912
41MP0003938_abnormal_ear_development1.28881392
42MP0005391_vision/eye_phenotype1.25676029
43MP0010678_abnormal_skin_adnexa1.19688806
44MP0009379_abnormal_foot_pigmentation1.19369352
45MP0005646_abnormal_pituitary_gland1.18016057
46MP0004019_abnormal_vitamin_homeostasis1.17037049
47MP0005551_abnormal_eye_electrophysiolog1.12274733
48MP0002734_abnormal_mechanical_nocicepti1.11888704
49MP0000955_abnormal_spinal_cord1.11737456
50MP0003861_abnormal_nervous_system1.10478282
51MP0003283_abnormal_digestive_organ1.10158569
52MP0002160_abnormal_reproductive_system1.09168698
53MP0001346_abnormal_lacrimal_gland1.06418746
54MP0001963_abnormal_hearing_physiology1.05885043
55MP0001299_abnormal_eye_distance/1.04575719
56MP0003121_genomic_imprinting1.03522119
57MP0002092_abnormal_eye_morphology1.02186060
58MP0006276_abnormal_autonomic_nervous1.01575248
59MP0005195_abnormal_posterior_eye1.01450393
60MP0003755_abnormal_palate_morphology1.01084901
61MP0002234_abnormal_pharynx_morphology1.00796916
62MP0001486_abnormal_startle_reflex1.00488836
63MP0001324_abnormal_eye_pigmentation0.99853290
64MP0001286_abnormal_eye_development0.99582191
65MP0002557_abnormal_social/conspecific_i0.99177733
66MP0003890_abnormal_embryonic-extraembry0.99133199
67MP0002102_abnormal_ear_morphology0.98987996
68MP0003942_abnormal_urinary_system0.98523640
69MP0002752_abnormal_somatic_nervous0.97855038
70MP0004885_abnormal_endolymph0.97592618
71MP0009780_abnormal_chondrocyte_physiolo0.94268772
72MP0000579_abnormal_nail_morphology0.92655323
73MP0009046_muscle_twitch0.91628394
74MP0002152_abnormal_brain_morphology0.91520481
75MP0000647_abnormal_sebaceous_gland0.90677324
76MP0002116_abnormal_craniofacial_bone0.90302904
77MP0005171_absent_coat_pigmentation0.88412384
78MP0003698_abnormal_male_reproductive0.86459028
79MP0009745_abnormal_behavioral_response0.83619618
80MP0005083_abnormal_biliary_tract0.83516172
81MP0002909_abnormal_adrenal_gland0.81349651
82MP0004142_abnormal_muscle_tone0.81318347
83MP0003787_abnormal_imprinting0.79329144
84MP0002168_other_aberrant_phenotype0.78834467
85MP0002751_abnormal_autonomic_nervous0.78030462
86MP0002882_abnormal_neuron_morphology0.77994275
87MP0001929_abnormal_gametogenesis0.77066021
88MP0002572_abnormal_emotion/affect_behav0.76708630
89MP0002697_abnormal_eye_size0.76391270
90MP0009053_abnormal_anal_canal0.74538188
91MP0002272_abnormal_nervous_system0.74199646
92MP0002111_abnormal_tail_morphology0.73398551
93MP0003119_abnormal_digestive_system0.73136840
94MP0001502_abnormal_circadian_rhythm0.71950599
95MP0005395_other_phenotype0.69910609
96MP0003011_delayed_dark_adaptation0.69685769
97MP0005389_reproductive_system_phenotype0.69674774
98MP0000534_abnormal_ureter_morphology0.68299585
99MP0002084_abnormal_developmental_patter0.68198587
100MP0002090_abnormal_vision0.65733945

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.92840588
2Abnormal respiratory motile cilium morphology (HP:0005938)9.92840588
3Abnormal respiratory motile cilium physiology (HP:0012261)9.81850481
4Abnormal ciliary motility (HP:0012262)9.70968719
5Dynein arm defect of respiratory motile cilia (HP:0012255)9.18278603
6Absent/shortened dynein arms (HP:0200106)9.18278603
7Rhinitis (HP:0012384)8.68824969
8Chronic bronchitis (HP:0004469)6.26528792
9Bronchiectasis (HP:0002110)6.08986362
10Nasal polyposis (HP:0100582)5.13760112
11True hermaphroditism (HP:0010459)5.13443818
12Pancreatic fibrosis (HP:0100732)4.84490582
13Occipital encephalocele (HP:0002085)4.48428762
14Pancreatic cysts (HP:0001737)4.16680436
15Abnormality of midbrain morphology (HP:0002418)4.14849676
16Molar tooth sign on MRI (HP:0002419)4.14849676
17Abnormality of the nasal mucosa (HP:0000433)4.09087831
18Cystic liver disease (HP:0006706)3.79810863
19Nephronophthisis (HP:0000090)3.75626418
20Chronic sinusitis (HP:0011109)3.66712630
21Infertility (HP:0000789)3.65777623
22Medial flaring of the eyebrow (HP:0010747)3.26984463
23Postaxial foot polydactyly (HP:0001830)3.24627036
24Chronic hepatic failure (HP:0100626)3.22958448
25Recurrent sinusitis (HP:0011108)3.17029941
26Bronchitis (HP:0012387)3.11198775
27Gait imbalance (HP:0002141)3.07687722
28Congenital primary aphakia (HP:0007707)3.07138759
29Aplasia/Hypoplasia of the tongue (HP:0010295)3.04395154
30Abnormality of the renal medulla (HP:0100957)2.91034150
31Anencephaly (HP:0002323)2.89350466
32Recurrent otitis media (HP:0000403)2.82769538
33Congenital hepatic fibrosis (HP:0002612)2.82576557
34Tubulointerstitial nephritis (HP:0001970)2.76996357
35Male infertility (HP:0003251)2.75499961
36Nephrogenic diabetes insipidus (HP:0009806)2.73347445
37Sclerocornea (HP:0000647)2.66181683
38Atelectasis (HP:0100750)2.65809089
39Postaxial hand polydactyly (HP:0001162)2.52948596
40Male pseudohermaphroditism (HP:0000037)2.49020362
41Vaginal atresia (HP:0000148)2.29887285
42Chronic otitis media (HP:0000389)2.29359290
43Genital tract atresia (HP:0001827)2.26850800
44Tubular atrophy (HP:0000092)2.24488988
45Preaxial hand polydactyly (HP:0001177)2.22762988
46Oculomotor apraxia (HP:0000657)2.21906663
47Abnormal biliary tract physiology (HP:0012439)2.16458080
48Bile duct proliferation (HP:0001408)2.16458080
49Supernumerary spleens (HP:0009799)2.16163490
50Poor coordination (HP:0002370)2.13590587
51Furrowed tongue (HP:0000221)2.10015860
52Median cleft lip (HP:0000161)2.06158107
53Aplasia/Hypoplasia of the spleen (HP:0010451)2.05339397
54Asplenia (HP:0001746)2.02166753
55Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.5157450
56Broad foot (HP:0001769)1.81851399
57Narrow forehead (HP:0000341)1.79171561
58Tubulointerstitial abnormality (HP:0001969)1.76676530
59Aganglionic megacolon (HP:0002251)1.65589747
60Hyperactive renin-angiotensin system (HP:0000841)1.61817308
61Holoprosencephaly (HP:0001360)1.61698175
62Nephropathy (HP:0000112)1.59310303
63Abnormal drinking behavior (HP:0030082)1.58357851
64Polydipsia (HP:0001959)1.58357851
65Prominent nasal bridge (HP:0000426)1.56398370
66Broad distal phalanx of finger (HP:0009836)1.56149186
67Decreased testicular size (HP:0008734)1.54022217
68Aplasia/Hypoplasia of the lens (HP:0008063)1.52405926
69Stage 5 chronic kidney disease (HP:0003774)1.48215184
70Specific learning disability (HP:0001328)1.47972783
71Multicystic kidney dysplasia (HP:0000003)1.45371560
72Renal dysplasia (HP:0000110)1.43699387
73Anophthalmia (HP:0000528)1.41104107
74Retinitis pigmentosa (HP:0000510)1.39419402
75Chorioretinal coloboma (HP:0000567)1.37299933
76Absent frontal sinuses (HP:0002688)1.37149131
77Highly arched eyebrow (HP:0002553)1.36973113
78Optic nerve coloboma (HP:0000588)1.33963076
79Abnormality of the renal cortex (HP:0011035)1.33490389
80Abnormality of dentin (HP:0010299)1.33138455
81Septo-optic dysplasia (HP:0100842)1.28887060
82Bell-shaped thorax (HP:0001591)1.28813972
83Bifid scrotum (HP:0000048)1.28086951
84Dandy-Walker malformation (HP:0001305)1.26346743
85Decreased central vision (HP:0007663)1.25161402
86Abnormality of permanent molar morphology (HP:0011071)1.24967483
87Abnormality of the dental root (HP:0006486)1.24967483
88Taurodontia (HP:0000679)1.24967483
89Abnormality of abdominal situs (HP:0011620)1.21276039
90Abdominal situs inversus (HP:0003363)1.21276039
91Iris coloboma (HP:0000612)1.20342884
92Fibular hypoplasia (HP:0003038)1.17992205
93Tubulointerstitial fibrosis (HP:0005576)1.17801519
94Short foot (HP:0001773)1.16326469
95Micropenis (HP:0000054)1.15986232
96Decreased circulating renin level (HP:0003351)1.15394313
97Left ventricular hypertrophy (HP:0001712)1.14629915
98Absent rod-and cone-mediated responses on ERG (HP:0007688)1.14422423
99Abnormality of the middle phalanges of the toes (HP:0010183)1.14089036
100Depressed nasal ridge (HP:0000457)1.13105185

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK158.80240102
2PNCK3.61014859
3EPHA32.83847507
4BCR2.75778303
5CASK2.73293785
6EPHA42.49736010
7WEE12.33351921
8MST42.16338948
9MAP3K42.14624108
10MAP4K21.92766684
11MAP2K71.86034930
12EPHA21.85982636
13DYRK31.83854560
14WNK31.59932517
15MAPK131.54187818
16TSSK61.49649166
17CDK191.40614847
18TRIM281.33156356
19TNIK1.32805715
20EPHB21.31268531
21CCNB11.31052192
22ERBB31.26465462
23MKNK11.25869717
24TLK11.21122399
25PRKD31.21084722
26NME11.20249077
27PTK2B1.16975895
28BRSK21.15692433
29TTK1.14425270
30PLK21.11797766
31BCKDK1.11481545
32PINK11.09094420
33DYRK21.08339418
34CSNK1G21.05845780
35STK38L1.04335508
36PASK1.03263486
37STK241.02244233
38DYRK1B0.99910686
39EPHB10.98331385
40CSNK1G30.98091170
41ERBB20.96542451
42VRK10.96315775
43WNK40.95501703
44IRAK10.94841099
45STK160.89465629
46CSNK1A1L0.89243998
47CSNK1G10.88162185
48DYRK1A0.86127772
49STK390.85528645
50MARK10.83271409
51MKNK20.80292719
52NTRK20.79624308
53GRK10.77868645
54BMPR1B0.75036925
55ADRBK20.71957279
56NEK90.69268808
57PLK10.67648397
58NUAK10.66691517
59PLK40.61703731
60PRKCG0.58433894
61CDC70.57474265
62PRKCE0.57201087
63NEK60.56651037
64UHMK10.55411374
65SRPK10.53476045
66PLK30.53201038
67MAP2K40.52698835
68TGFBR10.51129570
69INSRR0.50714583
70CDK30.46163547
71MAPKAPK30.45898726
72PKN10.45146412
73AURKA0.43024150
74VRK20.42943152
75CAMK2A0.42751619
76FER0.42613586
77LRRK20.41165265
78RPS6KA40.41000221
79ROCK20.41000036
80PRKACA0.39248764
81ZAK0.38456128
82PRKCI0.36484573
83NTRK30.35344831
84PAK30.35100026
85CHEK20.34742714
86NLK0.32965515
87CSNK1A10.30992419
88MAP3K70.29817534
89OXSR10.28773364
90ICK0.28021804
91PRKCZ0.27083402
92MUSK0.27066673
93CHUK0.26595576
94MINK10.25857500
95CDK50.25096685
96PRKG10.24805443
97BRSK10.23671765
98DMPK0.23389634
99CAMK2G0.23300881
100SGK2230.22588301

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.58964008
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.47790473
3Huntingtons disease_Homo sapiens_hsa050163.08936146
4Chemical carcinogenesis_Homo sapiens_hsa052042.88153982
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.84236991
6Basal cell carcinoma_Homo sapiens_hsa052172.57581588
7Histidine metabolism_Homo sapiens_hsa003402.49813658
8Phenylalanine metabolism_Homo sapiens_hsa003602.42625664
9Hedgehog signaling pathway_Homo sapiens_hsa043402.15808781
10Steroid biosynthesis_Homo sapiens_hsa001002.12828077
11beta-Alanine metabolism_Homo sapiens_hsa004102.11332676
12Protein export_Homo sapiens_hsa030602.04523946
13Tyrosine metabolism_Homo sapiens_hsa003502.00559681
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.92129750
15Glutathione metabolism_Homo sapiens_hsa004801.90326657
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.89229535
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68420754
18Propanoate metabolism_Homo sapiens_hsa006401.65964115
19Butanoate metabolism_Homo sapiens_hsa006501.62615729
20Linoleic acid metabolism_Homo sapiens_hsa005911.62428554
21Caffeine metabolism_Homo sapiens_hsa002321.59589099
22Retinol metabolism_Homo sapiens_hsa008301.59276290
23Oxidative phosphorylation_Homo sapiens_hsa001901.57511305
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.51386403
25Peroxisome_Homo sapiens_hsa041461.48662422
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43892247
27Nicotine addiction_Homo sapiens_hsa050331.42720257
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.42442251
29Nitrogen metabolism_Homo sapiens_hsa009101.39712050
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37373545
31Hippo signaling pathway_Homo sapiens_hsa043901.34906956
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.28470372
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28292918
34Parkinsons disease_Homo sapiens_hsa050121.24163579
35Tight junction_Homo sapiens_hsa045301.21996264
36Fanconi anemia pathway_Homo sapiens_hsa034601.18280032
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.16704588
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14517662
39Phototransduction_Homo sapiens_hsa047441.12409912
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12248252
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04534903
42Fatty acid degradation_Homo sapiens_hsa000711.02505861
43Axon guidance_Homo sapiens_hsa043601.02094759
44Taste transduction_Homo sapiens_hsa047421.01773916
45Cardiac muscle contraction_Homo sapiens_hsa042601.01476951
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00931098
47Notch signaling pathway_Homo sapiens_hsa043300.99302287
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96640603
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93616705
50ABC transporters_Homo sapiens_hsa020100.91228032
51Olfactory transduction_Homo sapiens_hsa047400.87223728
52Circadian rhythm_Homo sapiens_hsa047100.87096976
53Alzheimers disease_Homo sapiens_hsa050100.85661283
54Cocaine addiction_Homo sapiens_hsa050300.82863863
55Tryptophan metabolism_Homo sapiens_hsa003800.79669309
56Melanogenesis_Homo sapiens_hsa049160.78103489
57Wnt signaling pathway_Homo sapiens_hsa043100.77755737
58Nucleotide excision repair_Homo sapiens_hsa034200.76750076
59Arachidonic acid metabolism_Homo sapiens_hsa005900.75806915
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73218263
61Folate biosynthesis_Homo sapiens_hsa007900.71640711
62Salivary secretion_Homo sapiens_hsa049700.70796403
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.70292996
64Metabolic pathways_Homo sapiens_hsa011000.68735200
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68477159
66Sphingolipid metabolism_Homo sapiens_hsa006000.67843688
67Basal transcription factors_Homo sapiens_hsa030220.67598294
68Arginine and proline metabolism_Homo sapiens_hsa003300.63836055
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.63561683
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59992918
71Ribosome_Homo sapiens_hsa030100.57300450
72Purine metabolism_Homo sapiens_hsa002300.56237025
73TGF-beta signaling pathway_Homo sapiens_hsa043500.55456871
74Spliceosome_Homo sapiens_hsa030400.54833641
75RNA polymerase_Homo sapiens_hsa030200.54031168
76Circadian entrainment_Homo sapiens_hsa047130.53242902
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52450082
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52436864
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52276312
80Homologous recombination_Homo sapiens_hsa034400.51646357
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48719146
82RNA degradation_Homo sapiens_hsa030180.48351366
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48079783
84GABAergic synapse_Homo sapiens_hsa047270.47878729
85Pyruvate metabolism_Homo sapiens_hsa006200.47535184
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45471772
87Collecting duct acid secretion_Homo sapiens_hsa049660.43918701
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43352991
89Regulation of autophagy_Homo sapiens_hsa041400.42854706
90Starch and sucrose metabolism_Homo sapiens_hsa005000.40453200
91cAMP signaling pathway_Homo sapiens_hsa040240.38851895
92Serotonergic synapse_Homo sapiens_hsa047260.34205418
93PPAR signaling pathway_Homo sapiens_hsa033200.33942878
94Dopaminergic synapse_Homo sapiens_hsa047280.33459997
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33265969
96Adherens junction_Homo sapiens_hsa045200.32102298
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.31278338
98Glycerolipid metabolism_Homo sapiens_hsa005610.31069278
99Ether lipid metabolism_Homo sapiens_hsa005650.30780724
100Glutamatergic synapse_Homo sapiens_hsa047240.29020930

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »