C6ORF106

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to endosome (GO:0036010)4.23796692
2regulation of early endosome to late endosome transport (GO:2000641)3.87526594
3NADH metabolic process (GO:0006734)3.65754278
4negative regulation of erythrocyte differentiation (GO:0045647)3.55823310
5cytoskeletal anchoring at plasma membrane (GO:0007016)3.54303874
6regulation of cholesterol homeostasis (GO:2000188)3.47304200
7focal adhesion assembly (GO:0048041)3.42338152
8cell-substrate adherens junction assembly (GO:0007045)3.42338152
9adherens junction assembly (GO:0034333)3.34377201
10COPI coating of Golgi vesicle (GO:0048205)3.20820338
11Golgi transport vesicle coating (GO:0048200)3.20820338
12creatine metabolic process (GO:0006600)3.20396328
13urea cycle (GO:0000050)3.07093426
14negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.04591630
15urea metabolic process (GO:0019627)3.03168370
16stress fiber assembly (GO:0043149)3.00466551
17negative regulation of fatty acid biosynthetic process (GO:0045717)2.91883087
18pinocytosis (GO:0006907)2.90337381
19nitrogen cycle metabolic process (GO:0071941)2.85747007
20cell-substrate junction assembly (GO:0007044)2.83036871
21embryonic process involved in female pregnancy (GO:0060136)2.82126819
22dicarboxylic acid biosynthetic process (GO:0043650)2.81680028
23oxaloacetate metabolic process (GO:0006107)2.80591640
243-UTR-mediated mRNA stabilization (GO:0070935)2.79088365
25mannose metabolic process (GO:0006013)2.78067014
26low-density lipoprotein particle clearance (GO:0034383)2.77906397
27sarcoplasmic reticulum calcium ion transport (GO:0070296)2.76877233
28positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.75438283
29retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.72108100
30positive regulation of myotube differentiation (GO:0010831)2.71617377
31cellular protein complex localization (GO:0034629)2.70077263
32barbed-end actin filament capping (GO:0051016)2.67491574
33fructose metabolic process (GO:0006000)2.65701584
34activation of MAPKKK activity (GO:0000185)2.62420074
35actin-myosin filament sliding (GO:0033275)2.59846874
36muscle filament sliding (GO:0030049)2.59846874
37cellular response to thyroid hormone stimulus (GO:0097067)2.57460605
38negative regulation of fibrinolysis (GO:0051918)2.56722531
39response to thyroid hormone (GO:0097066)2.53878351
40apoptotic process involved in morphogenesis (GO:0060561)2.52616542
41response to laminar fluid shear stress (GO:0034616)2.50957930
42epithelial cell-cell adhesion (GO:0090136)2.50546422
43activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.50371869
44protein-lipid complex assembly (GO:0065005)2.49614591
45modulation by symbiont of host cellular process (GO:0044068)2.48952211
46tricarboxylic acid metabolic process (GO:0072350)2.47514045
47negative regulation of cell size (GO:0045792)2.47055387
48positive regulation of Cdc42 GTPase activity (GO:0043089)2.45601153
49activation of Rac GTPase activity (GO:0032863)2.44431299
50skeletal muscle contraction (GO:0003009)2.43367888
51endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.42737499
52regulation of fatty acid biosynthetic process (GO:0042304)2.42534210
53gluconeogenesis (GO:0006094)2.41808268
54regulation of ARF protein signal transduction (GO:0032012)2.41547646
55positive regulation of extracellular matrix organization (GO:1903055)2.38759571
56positive regulation of nuclease activity (GO:0032075)2.38409618
57sodium ion export (GO:0071436)2.37496988
58maternal placenta development (GO:0001893)2.37348994
59negative regulation of protein localization to plasma membrane (GO:1903077)2.35638603
60positive regulation of cellular amide metabolic process (GO:0034250)2.35456990
61negative regulation of necroptotic process (GO:0060546)2.34873746
62regulation of cholesterol biosynthetic process (GO:0045540)2.34816493
63negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.34456338
64pentose-phosphate shunt (GO:0006098)2.33983309
65regulation of histone H3-K27 methylation (GO:0061085)2.33895286
66desmosome organization (GO:0002934)2.33818101
67epithelial cell differentiation involved in prostate gland development (GO:0060742)2.33336176
68response to mercury ion (GO:0046689)2.32543792
69hypotonic response (GO:0006971)2.30874656
70positive regulation of receptor recycling (GO:0001921)2.30695638
71hexose biosynthetic process (GO:0019319)2.30404222
72monosaccharide biosynthetic process (GO:0046364)2.30272513
73regulation of glucose import in response to insulin stimulus (GO:2001273)2.29050972
74regulation of cholesterol storage (GO:0010885)2.28954519
75negative regulation of lipid transport (GO:0032369)2.28874874
76surfactant homeostasis (GO:0043129)2.28753837
77glucose 6-phosphate metabolic process (GO:0051156)2.25789895
78cortical actin cytoskeleton organization (GO:0030866)2.23154134
79intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.23110751
80skin morphogenesis (GO:0043589)2.22973115
81negative regulation of potassium ion transmembrane transport (GO:1901380)2.22750723
82basement membrane organization (GO:0071711)2.22040304
83regulation of nucleobase-containing compound transport (GO:0032239)2.21364500
84positive regulation of Rap GTPase activity (GO:0032854)2.21187145
85glycogen catabolic process (GO:0005980)2.20363016
86very-low-density lipoprotein particle assembly (GO:0034379)2.19441901
87regulation of extracellular matrix disassembly (GO:0010715)2.18970104
88ER-nucleus signaling pathway (GO:0006984)2.18538372
89endoplasmic reticulum unfolded protein response (GO:0030968)2.17506879
90regulation of fibrinolysis (GO:0051917)2.17386042
91regulation of NFAT protein import into nucleus (GO:0051532)2.17160805
92regulation of nuclease activity (GO:0032069)2.17136893
93protein complex localization (GO:0031503)2.16381773
94striated muscle contraction (GO:0006941)2.15854737
95negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.15575719
96positive regulation of protein dephosphorylation (GO:0035307)2.15555576
97peptidyl-threonine phosphorylation (GO:0018107)2.15123461
98fatty acid homeostasis (GO:0055089)2.14566922
99regulation of necroptotic process (GO:0060544)2.13010845
100cellular hyperosmotic response (GO:0071474)2.12896318

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.44370522
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.75974718
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.58486830
4MYC_22102868_ChIP-Seq_BL_Human2.57008569
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.49406938
6LXR_22292898_ChIP-Seq_THP-1_Human2.40707505
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.35038158
8NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.30230553
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.24905748
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.21106222
11TCF7_22412390_ChIP-Seq_EML_Mouse2.16193682
12ELK3_25401928_ChIP-Seq_HUVEC_Human2.15679699
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.15081659
14CLOCK_20551151_ChIP-Seq_293T_Human2.14887629
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.05092069
16RACK7_27058665_Chip-Seq_MCF-7_Human2.04268685
17VDR_21846776_ChIP-Seq_THP-1_Human2.02431114
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92684720
19ZNF263_19887448_ChIP-Seq_K562_Human1.92384898
20KDM2B_26808549_Chip-Seq_DND41_Human1.88382125
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.87523780
22RXR_22158963_ChIP-Seq_LIVER_Mouse1.84647052
23PPARA_22158963_ChIP-Seq_LIVER_Mouse1.76689229
24KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.75567088
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.74317602
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72499506
27KDM2B_26808549_Chip-Seq_K562_Human1.70445350
28KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.65583061
29RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.62640505
30ZFP281_18757296_ChIP-ChIP_E14_Mouse1.55655074
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.51694852
32P300_27058665_Chip-Seq_ZR-75-30cells_Human1.50691335
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49750408
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.49563216
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48208429
36TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.46447171
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.43214172
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.40927370
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39503242
40TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39453937
41MAF_26560356_Chip-Seq_TH1_Human1.39233795
42SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.37292803
43GATA1_19941826_ChIP-Seq_K562_Human1.36544281
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34982477
45* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.34920485
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34442749
47TBX20_22080862_ChIP-Seq_HEART_Mouse1.33665661
48TBX20_22328084_ChIP-Seq_HEART_Mouse1.33665661
49NCOR1_26117541_ChIP-Seq_K562_Human1.33191361
50SMC4_20622854_ChIP-Seq_HELA_Human1.32951697
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31351358
52NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.31333507
53VDR_24763502_ChIP-Seq_THP-1_Human1.31102287
54LXR_22158963_ChIP-Seq_LIVER_Mouse1.30366465
55GATA1_19941827_ChIP-Seq_MEL_Mouse1.30095180
56EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.29431166
57TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26345147
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26240956
59* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26114021
60ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.25284230
61CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25217409
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24435660
63KDM2B_26808549_Chip-Seq_JURKAT_Human1.23790484
64SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23660298
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22078987
66ATF3_27146783_Chip-Seq_COLON_Human1.21578970
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20673725
68SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19589877
69RUNX1_22412390_ChIP-Seq_EML_Mouse1.19038951
70CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18809719
71* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17947621
72CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17391253
73CREB1_26743006_Chip-Seq_LNCaP_Human1.15554758
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13198291
75SPI1_23127762_ChIP-Seq_K562_Human1.12534499
76GATA1_22025678_ChIP-Seq_K562_Human1.12211437
77SA1_27219007_Chip-Seq_ERYTHROID_Human1.11565695
78GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.11447994
79NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.10614241
80CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10467875
81P68_20966046_ChIP-Seq_HELA_Human1.09561502
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08239322
83TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08047963
84TET1_21451524_ChIP-Seq_MESCs_Mouse1.07273688
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.05946459
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05767864
87SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04786198
88MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04189436
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04150608
90STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04017198
91SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03068083
92DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99597505
93MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99532243
94SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99160252
95MAF_26560356_Chip-Seq_TH2_Human0.98024152
96UTX_26944678_Chip-Seq_JUKART_Human0.97669530
97SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96705459
98SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96511901
99NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96206286
100ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95601476

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.41123362
2MP0003705_abnormal_hypodermis_morpholog3.56145294
3MP0009840_abnormal_foam_cell3.14078067
4MP0010234_abnormal_vibrissa_follicle2.97198181
5MP0003191_abnormal_cellular_cholesterol2.75127797
6MP0005058_abnormal_lysosome_morphology2.63534389
7MP0004233_abnormal_muscle_weight2.58639021
8MP0002139_abnormal_hepatobiliary_system2.54680034
9MP0000751_myopathy2.47037911
10MP0003566_abnormal_cell_adhesion2.34491475
11MP0002877_abnormal_melanocyte_morpholog2.10306565
12MP0008260_abnormal_autophagy1.98788413
13MP0004185_abnormal_adipocyte_glucose1.93942408
14MP0003303_peritoneal_inflammation1.93801792
15MP0005076_abnormal_cell_differentiation1.93767077
16MP0000747_muscle_weakness1.89545378
17MP0003453_abnormal_keratinocyte_physiol1.85386598
18MP0004510_myositis1.81327402
19MP0004087_abnormal_muscle_fiber1.79962465
20MP0005666_abnormal_adipose_tissue1.76781473
21MP0004036_abnormal_muscle_relaxation1.72046392
22MP0002796_impaired_skin_barrier1.70969550
23MP0003646_muscle_fatigue1.69951477
24MP0003300_gastrointestinal_ulcer1.69890150
25MP0003091_abnormal_cell_migration1.69748885
26MP0000749_muscle_degeneration1.66902190
27MP0005409_darkened_coat_color1.59471960
28MP0003656_abnormal_erythrocyte_physiolo1.59377695
29MP0000759_abnormal_skeletal_muscle1.57635526
30MP0005375_adipose_tissue_phenotype1.54860263
31MP0005257_abnormal_intraocular_pressure1.48320311
32MP0002269_muscular_atrophy1.41439167
33MP0000003_abnormal_adipose_tissue1.38900388
34MP0010630_abnormal_cardiac_muscle1.38652125
35MP0003172_abnormal_lysosome_physiology1.38241659
36MP0008438_abnormal_cutaneous_collagen1.35682056
37MP0004947_skin_inflammation1.33998987
38MP0005330_cardiomyopathy1.32690414
39MP0000733_abnormal_muscle_development1.30799593
40MP0003329_amyloid_beta_deposits1.30322283
41MP0001348_abnormal_lacrimal_gland1.29854788
42MP0004130_abnormal_muscle_cell1.27785922
43MP0002971_abnormal_brown_adipose1.26951195
44MP0010352_gastrointestinal_tract_polyps1.24291096
45MP0001849_ear_inflammation1.22425216
46MP0002106_abnormal_muscle_physiology1.21438083
47MP0005670_abnormal_white_adipose1.18312485
48MP0003075_altered_response_to1.15263672
49MP0005464_abnormal_platelet_physiology1.14996484
50MP0006138_congestive_heart_failure1.14669767
51MP0004084_abnormal_cardiac_muscle1.13760279
52MP0004264_abnormal_extraembryonic_tissu1.12897743
53MP0000750_abnormal_muscle_regeneration1.10885602
54MP0003436_decreased_susceptibility_to1.10445618
55MP0000858_altered_metastatic_potential1.09672674
56MP0005023_abnormal_wound_healing1.08629852
57MP0002332_abnormal_exercise_endurance1.06656157
58MP0009672_abnormal_birth_weight1.03813694
59MP0005365_abnormal_bile_salt1.02137910
60MP0009780_abnormal_chondrocyte_physiolo1.01712378
61MP0000604_amyloidosis1.01674963
62MP0001661_extended_life_span1.00339141
63MP0004858_abnormal_nervous_system0.99677330
64MP0003828_pulmonary_edema0.98222915
65MP0005501_abnormal_skin_physiology0.97854742
66MP0002998_abnormal_bone_remodeling0.96840852
67MP0008874_decreased_physiological_sensi0.95845722
68MP0001915_intracranial_hemorrhage0.94203639
69MP0000609_abnormal_liver_physiology0.91970117
70MP0003690_abnormal_glial_cell0.91358481
71MP0003221_abnormal_cardiomyocyte_apopto0.91202727
72MP0005369_muscle_phenotype0.91120587
73MP0003045_fibrosis0.89920713
74MP0003950_abnormal_plasma_membrane0.89815382
75MP0004272_abnormal_basement_membrane0.87651486
76MP0009115_abnormal_fat_cell0.86064141
77MP0005166_decreased_susceptibility_to0.85966532
78MP0002089_abnormal_postnatal_growth/wei0.85407019
79MP0009333_abnormal_splenocyte_physiolog0.85362318
80MP0000685_abnormal_immune_system0.85111272
81MP0000678_abnormal_parathyroid_gland0.84405166
82MP0005621_abnormal_cell_physiology0.82532298
83MP0002972_abnormal_cardiac_muscle0.82335341
84MP0001730_embryonic_growth_arrest0.81585031
85MP0003868_abnormal_feces_composition0.78811604
86MP0002060_abnormal_skin_morphology0.76663718
87MP0003879_abnormal_hair_cell0.76440530
88MP0003763_abnormal_thymus_physiology0.75041975
89MP0005165_increased_susceptibility_to0.73556932
90MP0005275_abnormal_skin_tensile0.72732996
91MP0005584_abnormal_enzyme/coenzyme_acti0.72043679
92MP0001851_eye_inflammation0.70404584
93MP0002166_altered_tumor_susceptibility0.70114850
94MP0004145_abnormal_muscle_electrophysio0.70090397
95MP0010329_abnormal_lipoprotein_level0.69828056
96MP0003183_abnormal_peptide_metabolism0.69695794
97MP0001853_heart_inflammation0.68176256
98MP0000767_abnormal_smooth_muscle0.67849933
99MP0001216_abnormal_epidermal_layer0.67638619
100MP0002118_abnormal_lipid_homeostasis0.65636059

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)4.16869602
2Muscle fiber inclusion bodies (HP:0100299)3.74314253
3Nemaline bodies (HP:0003798)3.71350215
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.66469010
5Centrally nucleated skeletal muscle fibers (HP:0003687)3.58126936
6Increased connective tissue (HP:0009025)3.35933124
7Type 1 muscle fiber predominance (HP:0003803)3.27497630
8Distal lower limb muscle weakness (HP:0009053)3.21779794
9Deep venous thrombosis (HP:0002625)2.95468013
10Myopathic facies (HP:0002058)2.95066170
11Abnormality of skeletal muscle fiber size (HP:0012084)2.83767319
12Distal lower limb amyotrophy (HP:0008944)2.82984308
13Hyporeflexia of lower limbs (HP:0002600)2.81714582
14Increased variability in muscle fiber diameter (HP:0003557)2.65442893
15Dysmetric saccades (HP:0000641)2.64783054
16Asymmetric septal hypertrophy (HP:0001670)2.64587224
17Abnormality of monocarboxylic acid metabolism (HP:0010996)2.57823054
18Rhabdomyolysis (HP:0003201)2.56701084
19Abnormal gallbladder physiology (HP:0012438)2.50190167
20Cholecystitis (HP:0001082)2.50190167
21EMG: myopathic abnormalities (HP:0003458)2.47519602
22Abnormality of the Achilles tendon (HP:0005109)2.41968404
23Exercise-induced muscle cramps (HP:0003710)2.41406197
24Achilles tendon contracture (HP:0001771)2.40057506
25Muscle fiber splitting (HP:0003555)2.32032544
26Difficulty running (HP:0009046)2.21307139
27Round ear (HP:0100830)2.18510048
28Abnormality of the left ventricular outflow tract (HP:0011103)2.15473539
29Subaortic stenosis (HP:0001682)2.15473539
30Vertebral compression fractures (HP:0002953)2.13425548
31Lower limb amyotrophy (HP:0007210)2.13033927
32Myoglobinuria (HP:0002913)2.11370325
33Obstructive sleep apnea (HP:0002870)2.09376628
34Ulnar deviation of the wrist (HP:0003049)2.09108297
35Muscle stiffness (HP:0003552)2.06100937
36Bundle branch block (HP:0011710)2.03851218
37Mildly elevated creatine phosphokinase (HP:0008180)2.03331607
38Abnormality of complement system (HP:0005339)2.02197276
39Cerebral aneurysm (HP:0004944)2.01847031
40Fatigue (HP:0012378)2.00317634
41Polycythemia (HP:0001901)1.99518721
42Cerebral inclusion bodies (HP:0100314)1.98362169
43Protrusio acetabuli (HP:0003179)1.97231664
44Sudden death (HP:0001699)1.96961872
45Systemic lupus erythematosus (HP:0002725)1.95764406
46Hemorrhage of the eye (HP:0011885)1.95261960
47Myocardial infarction (HP:0001658)1.94577726
48Ankyloglossia (HP:0010296)1.94094323
49Foot dorsiflexor weakness (HP:0009027)1.92987564
50Reticulocytosis (HP:0001923)1.91323659
51Ventricular tachycardia (HP:0004756)1.91252821
52Neck muscle weakness (HP:0000467)1.90792705
53Spinal rigidity (HP:0003306)1.90577725
54Flat acetabular roof (HP:0003180)1.88823360
55Xanthomatosis (HP:0000991)1.87502545
56Gastrointestinal stroma tumor (HP:0100723)1.85306177
57Complement deficiency (HP:0004431)1.85131470
58Right ventricular cardiomyopathy (HP:0011663)1.84367385
59Cholelithiasis (HP:0001081)1.84054936
60Advanced eruption of teeth (HP:0006288)1.82891932
61Eczematoid dermatitis (HP:0000976)1.81785215
62Osteolytic defects of the phalanges of the hand (HP:0009771)1.81718564
63Osteolytic defects of the hand bones (HP:0009699)1.81718564
64Upper limb amyotrophy (HP:0009129)1.81246681
65Distal upper limb amyotrophy (HP:0007149)1.81246681
66Abnormality of the fingertips (HP:0001211)1.80755813
67Ragged-red muscle fibers (HP:0003200)1.80680041
68Hyperacusis (HP:0010780)1.78500690
69Segmental peripheral demyelination/remyelination (HP:0003481)1.74392373
70Abnormality of the foot musculature (HP:0001436)1.74160156
71Progressive external ophthalmoplegia (HP:0000590)1.73312243
72Distal arthrogryposis (HP:0005684)1.72955954
73Progressive muscle weakness (HP:0003323)1.71490415
74Bulbar palsy (HP:0001283)1.71464462
75Neurofibrillary tangles (HP:0002185)1.70980950
76Abnormality of the salivary glands (HP:0010286)1.68598157
77Axonal loss (HP:0003447)1.68297347
78Dysostosis multiplex (HP:0000943)1.66746440
79Difficulty climbing stairs (HP:0003551)1.65681167
80Abnormal atrioventricular conduction (HP:0005150)1.63537101
81Abnormality of the common coagulation pathway (HP:0010990)1.63485200
82Cellulitis (HP:0100658)1.63231241
83Atrioventricular block (HP:0001678)1.62283166
84Glomerulonephritis (HP:0000099)1.61785324
85Decreased motor nerve conduction velocity (HP:0003431)1.61285177
86Hypercholesterolemia (HP:0003124)1.60002693
87Abnormality of liposaccharide metabolism (HP:0010968)1.59815635
88Abnormality of glycosphingolipid metabolism (HP:0004343)1.59815635
89Abnormality of glycolipid metabolism (HP:0010969)1.59815635
90Premature rupture of membranes (HP:0001788)1.59516293
91Slow saccadic eye movements (HP:0000514)1.58745504
92Aneurysm (HP:0002617)1.58738989
93Back pain (HP:0003418)1.57706492
94Abnormal gallbladder morphology (HP:0012437)1.57345695
95Colitis (HP:0002583)1.57229372
96Bowel incontinence (HP:0002607)1.56927850
97Frequent falls (HP:0002359)1.55692791
98Emphysema (HP:0002097)1.53512485
99Supranuclear gaze palsy (HP:0000605)1.53499214
100Mucopolysacchariduria (HP:0008155)1.53157850

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.96694265
2TRIB33.53866855
3EEF2K3.22818922
4TTN2.73060948
5RIPK12.61287721
6SMG12.46462817
7KSR22.43717379
8ICK2.41468943
9IRAK32.29346798
10ERN12.24271049
11CDK122.08812536
12FGFR42.08502914
13RIPK41.95176216
14MAP3K131.83872115
15SIK11.72252297
16MAP2K31.69446362
17OBSCN1.67508139
18LATS21.64526508
19MAP3K91.56077649
20MAP3K21.49078939
21MAP3K31.48143751
22ARAF1.45582910
23TAOK21.34188495
24MAP3K11.33066239
25PDGFRA1.24766727
26PDPK11.23847119
27PHKG21.22783539
28PHKG11.22783539
29MAPK121.10925794
30STK241.10154115
31MAP3K101.09984849
32MAPK111.06016859
33FGFR31.05501599
34DMPK0.97237451
35NME20.96634061
36TYK20.96354542
37BMX0.95304117
38CDC42BPA0.89192587
39LMTK20.88832369
40MAP3K140.88223323
41MTOR0.88081459
42SGK30.87943734
43EPHA20.85893385
44PDK10.85566776
45MAP3K80.84520393
46TESK10.83983275
47SCYL20.81050319
48MARK20.80691579
49RAF10.78662770
50KSR10.77695611
51TAOK10.76385446
52MST1R0.75126515
53PAK40.74338120
54BRAF0.73641399
55JAK30.73272665
56TRPM70.72621568
57EPHB10.72259714
58NEK90.70826862
59TBK10.70666496
60JAK10.69021638
61ZAP700.67128010
62STK380.65948313
63WNK10.65905396
64IRAK20.65363464
65PKN20.63990519
66MAP4K10.63470243
67MOS0.60785926
68PTK60.60752724
69RET0.59424049
70MAP3K110.59147455
71RPS6KA20.58691594
72DDR20.57967350
73MAPKAPK30.57232609
74MAP3K70.55020276
75MAP2K10.54958630
76MAP3K60.54825842
77PTK20.54091998
78ALK0.53705180
79CDK60.52573796
80RPS6KC10.51113355
81RPS6KL10.51113355
82PRKG20.50233645
83CDK40.49935402
84SIK30.49539298
85CAMK1D0.49441172
86RPS6KB20.47750197
87PRKD20.46882732
88LRRK20.46266878
89PRKAA20.46136934
90HIPK20.45794576
91AKT20.45685402
92IRAK40.45536838
93JAK20.43711952
94TYRO30.43059319
95PRKD30.42871085
96MAPK100.39576989
97CAMK40.37637431
98MAPK70.37615473
99MELK0.31288713
100CSK0.30543667

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.74235300
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.54446375
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.16974621
4Other glycan degradation_Homo sapiens_hsa005112.09415272
5Arginine biosynthesis_Homo sapiens_hsa002202.03561545
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.71467032
7Pentose phosphate pathway_Homo sapiens_hsa000301.70818277
8Insulin signaling pathway_Homo sapiens_hsa049101.64530682
9B cell receptor signaling pathway_Homo sapiens_hsa046621.59450956
10Chronic myeloid leukemia_Homo sapiens_hsa052201.58860123
11Prion diseases_Homo sapiens_hsa050201.53787254
12Acute myeloid leukemia_Homo sapiens_hsa052211.53533796
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43247388
14VEGF signaling pathway_Homo sapiens_hsa043701.41811392
15Non-small cell lung cancer_Homo sapiens_hsa052231.39692149
16Fructose and mannose metabolism_Homo sapiens_hsa000511.35860852
17Renal cell carcinoma_Homo sapiens_hsa052111.34683100
18Central carbon metabolism in cancer_Homo sapiens_hsa052301.30068715
19Carbon metabolism_Homo sapiens_hsa012001.29939650
20Long-term potentiation_Homo sapiens_hsa047201.29760727
21Biosynthesis of amino acids_Homo sapiens_hsa012301.28826862
22Thyroid cancer_Homo sapiens_hsa052161.20351995
23Neurotrophin signaling pathway_Homo sapiens_hsa047221.17032701
24GnRH signaling pathway_Homo sapiens_hsa049121.16099955
25Pancreatic cancer_Homo sapiens_hsa052121.14204602
26AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13965472
27Insulin resistance_Homo sapiens_hsa049311.13587296
28AMPK signaling pathway_Homo sapiens_hsa041521.13553691
29Complement and coagulation cascades_Homo sapiens_hsa046101.13507506
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11536265
31Phenylalanine metabolism_Homo sapiens_hsa003601.10868971
32Glioma_Homo sapiens_hsa052141.10034829
33Adipocytokine signaling pathway_Homo sapiens_hsa049201.09143551
34Endometrial cancer_Homo sapiens_hsa052131.07755890
35Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03673887
36Bladder cancer_Homo sapiens_hsa052191.03217164
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.01012172
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00870517
39Glucagon signaling pathway_Homo sapiens_hsa049220.98346435
40PPAR signaling pathway_Homo sapiens_hsa033200.96655614
41Galactose metabolism_Homo sapiens_hsa000520.95010955
42ErbB signaling pathway_Homo sapiens_hsa040120.94191947
43mTOR signaling pathway_Homo sapiens_hsa041500.92510026
44Osteoclast differentiation_Homo sapiens_hsa043800.92441291
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92354970
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91195795
47Focal adhesion_Homo sapiens_hsa045100.89405805
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87822844
49Amoebiasis_Homo sapiens_hsa051460.87573275
50Proteoglycans in cancer_Homo sapiens_hsa052050.86862254
51Hepatitis C_Homo sapiens_hsa051600.86227759
52Vitamin B6 metabolism_Homo sapiens_hsa007500.85368184
53Inositol phosphate metabolism_Homo sapiens_hsa005620.84564681
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84101586
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.82757302
56Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81811564
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81153286
58HIF-1 signaling pathway_Homo sapiens_hsa040660.80819680
59Arginine and proline metabolism_Homo sapiens_hsa003300.79761273
60Bile secretion_Homo sapiens_hsa049760.78957193
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78814819
62Adherens junction_Homo sapiens_hsa045200.78267049
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.77884963
64Toxoplasmosis_Homo sapiens_hsa051450.75939688
65Influenza A_Homo sapiens_hsa051640.75721345
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75586426
67Prolactin signaling pathway_Homo sapiens_hsa049170.75247377
68Staphylococcus aureus infection_Homo sapiens_hsa051500.74699755
69Leishmaniasis_Homo sapiens_hsa051400.74304914
70Estrogen signaling pathway_Homo sapiens_hsa049150.73499920
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73401835
72Dilated cardiomyopathy_Homo sapiens_hsa054140.73356997
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72093093
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.71507292
75Lysosome_Homo sapiens_hsa041420.70977857
76Viral myocarditis_Homo sapiens_hsa054160.69912867
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.69801964
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66042694
79Apoptosis_Homo sapiens_hsa042100.65941924
80Endocytosis_Homo sapiens_hsa041440.65404615
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64621482
82Prostate cancer_Homo sapiens_hsa052150.64168515
83Hepatitis B_Homo sapiens_hsa051610.63757230
84Tuberculosis_Homo sapiens_hsa051520.62778242
85Lysine degradation_Homo sapiens_hsa003100.62772037
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59276901
87Small cell lung cancer_Homo sapiens_hsa052220.59230427
88Choline metabolism in cancer_Homo sapiens_hsa052310.58008525
89TNF signaling pathway_Homo sapiens_hsa046680.56569163
90Starch and sucrose metabolism_Homo sapiens_hsa005000.55452817
91Pertussis_Homo sapiens_hsa051330.53142764
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52916239
93T cell receptor signaling pathway_Homo sapiens_hsa046600.52773731
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52099873
95Type II diabetes mellitus_Homo sapiens_hsa049300.48520073
96Fatty acid biosynthesis_Homo sapiens_hsa000610.46077086
97FoxO signaling pathway_Homo sapiens_hsa040680.45887195
98Fatty acid degradation_Homo sapiens_hsa000710.45792984
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45697107
100Shigellosis_Homo sapiens_hsa051310.45464570

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