C6ORF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.34162658
2protein maturation by protein folding (GO:0022417)4.05928995
3synaptic vesicle exocytosis (GO:0016079)4.00971812
4response to gravity (GO:0009629)3.86564516
5energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.79215950
6ATP hydrolysis coupled proton transport (GO:0015991)3.79215950
7positive regulation of TOR signaling (GO:0032008)3.71099870
8glutamate secretion (GO:0014047)3.69504427
9negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.66875167
10deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.52154429
11synaptic vesicle docking involved in exocytosis (GO:0016081)3.48262668
12regulation of synapse structural plasticity (GO:0051823)3.40210005
13positive regulation of actin filament depolymerization (GO:0030836)3.33756247
14GDP-mannose metabolic process (GO:0019673)3.27213416
15transferrin transport (GO:0033572)3.26297851
16phagosome maturation (GO:0090382)3.25489747
17protein complex biogenesis (GO:0070271)3.23724190
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.10422778
19negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.08474743
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.02862437
21ferric iron transport (GO:0015682)3.02207768
22trivalent inorganic cation transport (GO:0072512)3.02207768
23platelet dense granule organization (GO:0060155)2.97923546
24regulation of autophagic vacuole assembly (GO:2000785)2.93612895
25amino sugar catabolic process (GO:0046348)2.90815430
26glucosamine-containing compound catabolic process (GO:1901072)2.89825656
27positive regulation of neurotransmitter secretion (GO:0001956)2.86540405
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.82418001
29mitochondrial respiratory chain complex I assembly (GO:0032981)2.82418001
30NADH dehydrogenase complex assembly (GO:0010257)2.82418001
31positive regulation of neurotransmitter transport (GO:0051590)2.73473289
32positive regulation of mitochondrial fission (GO:0090141)2.72966441
33mannosylation (GO:0097502)2.72772428
34negative regulation of cation channel activity (GO:2001258)2.71496326
35C-terminal protein lipidation (GO:0006501)2.69910463
36positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.69453509
37regulation of synaptic vesicle exocytosis (GO:2000300)2.67625810
38mitochondrial respiratory chain complex assembly (GO:0033108)2.67111419
39Arp2/3 complex-mediated actin nucleation (GO:0034314)2.67070019
40neurotransmitter secretion (GO:0007269)2.65696574
41respiratory electron transport chain (GO:0022904)2.65004014
42regulation of vacuole organization (GO:0044088)2.63547121
43regulation of short-term neuronal synaptic plasticity (GO:0048172)2.62799124
44electron transport chain (GO:0022900)2.62730433
45positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.61596240
46inositol phosphate catabolic process (GO:0071545)2.61525589
47positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.61446481
48melanin biosynthetic process (GO:0042438)2.60387533
49iron-sulfur cluster assembly (GO:0016226)2.59976523
50metallo-sulfur cluster assembly (GO:0031163)2.59976523
51protein insertion into membrane (GO:0051205)2.59594424
52actin nucleation (GO:0045010)2.57491118
53phosphorylated carbohydrate dephosphorylation (GO:0046838)2.52844678
54inositol phosphate dephosphorylation (GO:0046855)2.52844678
55negative regulation of glycoprotein metabolic process (GO:1903019)2.49798997
56cytochrome complex assembly (GO:0017004)2.41373463
57nuclear envelope reassembly (GO:0031468)2.41338665
58mitotic nuclear envelope reassembly (GO:0007084)2.41338665
59regulation of protein kinase A signaling (GO:0010738)2.40576908
60sequestering of actin monomers (GO:0042989)2.39906503
61adenosine receptor signaling pathway (GO:0001973)2.37688830
62type B pancreatic cell proliferation (GO:0044342)2.36751523
63respiratory chain complex IV assembly (GO:0008535)2.35708615
64regulation of synaptic vesicle transport (GO:1902803)2.33733624
65hydrogen ion transmembrane transport (GO:1902600)2.32790811
66synaptic transmission, glutamatergic (GO:0035249)2.31756770
67glycosphingolipid biosynthetic process (GO:0006688)2.31482028
68mitochondrial calcium ion homeostasis (GO:0051560)2.31225202
69extracellular fibril organization (GO:0043206)2.29961675
70regulation of amyloid precursor protein catabolic process (GO:1902991)2.29894142
71cellular response to zinc ion (GO:0071294)2.29139960
72negative regulation of calcium ion transmembrane transport (GO:1903170)2.26109964
73negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.26109964
74negative regulation of synaptic transmission, GABAergic (GO:0032229)2.25423545
75pyrimidine-containing compound salvage (GO:0008655)2.25215505
76pyrimidine nucleoside salvage (GO:0043097)2.25215505
77C-terminal protein amino acid modification (GO:0018410)2.23525523
78cellular potassium ion homeostasis (GO:0030007)2.23187240
79endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.20236980
80deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.19785530
81gamma-aminobutyric acid transport (GO:0015812)2.18918604
82fibril organization (GO:0097435)2.18852562
83proton transport (GO:0015992)2.18348912
84DNA deamination (GO:0045006)2.17464746
85membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.16365187
86hydrogen transport (GO:0006818)2.16063478
87deoxyribose phosphate biosynthetic process (GO:0046385)2.15757516
882-deoxyribonucleotide biosynthetic process (GO:0009265)2.15757516
89GPI anchor biosynthetic process (GO:0006506)2.15747466
90viral protein processing (GO:0019082)2.14190883
91virion assembly (GO:0019068)2.10977805
92endosome to pigment granule transport (GO:0043485)2.10959059
93endosome to melanosome transport (GO:0035646)2.10959059
94energy coupled proton transport, down electrochemical gradient (GO:0015985)2.10742460
95ATP synthesis coupled proton transport (GO:0015986)2.10742460
96response to interferon-beta (GO:0035456)2.10308409
97melanin metabolic process (GO:0006582)2.09120126
98glycolipid biosynthetic process (GO:0009247)2.07873294
99adaptation of signaling pathway (GO:0023058)2.07509602
100synaptic vesicle endocytosis (GO:0048488)2.06204017

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.90189946
2CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.80711399
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.73695082
4CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.32594888
5PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.26506540
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25817184
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.25602625
8IKZF1_21737484_ChIP-ChIP_HCT116_Human2.21383275
9ELF1_20517297_ChIP-Seq_JURKAT_Human2.15714569
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.05522433
11SRY_22984422_ChIP-ChIP_TESTIS_Rat2.04801375
12* BCL6_27268052_Chip-Seq_Bcells_Human2.02000667
13LXR_22292898_ChIP-Seq_THP-1_Human1.97429265
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.97071809
15SRF_21415370_ChIP-Seq_HL-1_Mouse1.95075032
16* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.91328900
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.90274966
18MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.89650589
19SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.88710382
20RARG_19884340_ChIP-ChIP_MEFs_Mouse1.87368149
21ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87249705
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81184632
23P68_20966046_ChIP-Seq_HELA_Human1.79967010
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.75467173
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.69716043
26* BCOR_27268052_Chip-Seq_Bcells_Human1.68225872
27TET1_21451524_ChIP-Seq_MESCs_Mouse1.65665603
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.63827727
29PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.57370290
30CTCF_20526341_ChIP-Seq_ESCs_Human1.52701097
31EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.52541517
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51714750
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.51629339
34SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.50893348
35SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.50702214
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.49208598
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.48422123
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48360630
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.46239992
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43243220
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43144925
42E2F1_20622854_ChIP-Seq_HELA_Human1.40133112
43DNAJC2_21179169_ChIP-ChIP_NT2_Human1.40048001
44GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.39761246
45* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.39749421
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38374018
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.37705102
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36820008
49* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35285893
50PHF8_20622854_ChIP-Seq_HELA_Human1.34068345
51TFEB_21752829_ChIP-Seq_HELA_Human1.33951203
52DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.33174520
53* ELK3_25401928_ChIP-Seq_HUVEC_Human1.30428080
54KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.29316784
55RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.27672191
56RARB_24833708_ChIP-Seq_LIVER_Mouse1.26192553
57GABP_19822575_ChIP-Seq_HepG2_Human1.24829896
58CTCF_18555785_ChIP-Seq_MESCs_Mouse1.24697481
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23767569
60RARB_27405468_Chip-Seq_BRAIN_Mouse1.23146231
61* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.22815568
62FOXP1_21924763_ChIP-Seq_HESCs_Human1.21657046
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.21194954
64SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18669121
65REST_21632747_ChIP-Seq_MESCs_Mouse1.18378581
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17367054
67YY1_22570637_ChIP-Seq_MALME-3M_Human1.16273142
68IRF8_21731497_ChIP-ChIP_J774_Mouse1.15530127
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.15056138
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14655377
71* VDR_21846776_ChIP-Seq_THP-1_Human1.13043031
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11948316
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11621724
74PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11194203
75IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.11057382
76SA1_27219007_Chip-Seq_Bcells_Human1.10661961
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10000360
78* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09412947
79MAF_26560356_Chip-Seq_TH2_Human1.09206304
80SPI1_20517297_ChIP-Seq_HL60_Human1.07520146
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06240696
82* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06063400
83PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05376172
84P300_27268052_Chip-Seq_Bcells_Human1.04975942
85CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04576548
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04267691
87SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03590279
88TET1_21490601_ChIP-Seq_MESCs_Mouse1.03544958
89CTCF_26484167_Chip-Seq_Bcells_Mouse1.02576326
90TAF2_19829295_ChIP-Seq_ESCs_Human0.99336821
91DCP1A_22483619_ChIP-Seq_HELA_Human0.98239735
92VDR_23849224_ChIP-Seq_CD4+_Human0.97966325
93SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.97715961
94* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97650462
95MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97013697
96* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96267023
97BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.96190517
98SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.96099630
99FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94861188
100STAT1_20625510_ChIP-Seq_HELA_Human0.94743553

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.39747711
2MP0005423_abnormal_somatic_nervous2.85492367
3MP0003880_abnormal_central_pattern2.79543536
4MP0005058_abnormal_lysosome_morphology2.60724008
5MP0005171_absent_coat_pigmentation2.58230831
6MP0001968_abnormal_touch/_nociception2.45044049
7MP0009046_muscle_twitch2.44524293
8MP0001905_abnormal_dopamine_level2.28034358
9MP0002064_seizures2.24817956
10MP0004270_analgesia2.19868762
11MP0003172_abnormal_lysosome_physiology2.16967525
12MP0003635_abnormal_synaptic_transmissio2.12964443
13MP0009745_abnormal_behavioral_response2.06328571
14MP0002272_abnormal_nervous_system1.97424366
15MP0002736_abnormal_nociception_after1.96532605
16MP0009840_abnormal_foam_cell1.92876364
17MP0003075_altered_response_to1.75678597
18MP0003806_abnormal_nucleotide_metabolis1.75664850
19MP0003329_amyloid_beta_deposits1.73730307
20MP0001970_abnormal_pain_threshold1.73557610
21MP0002063_abnormal_learning/memory/cond1.71147078
22MP0004510_myositis1.70294717
23MP0001502_abnormal_circadian_rhythm1.69620630
24MP0001986_abnormal_taste_sensitivity1.66930435
25MP0002572_abnormal_emotion/affect_behav1.64938166
26MP0000015_abnormal_ear_pigmentation1.63355037
27MP0000343_altered_response_to1.61022382
28MP0000372_irregular_coat_pigmentation1.58739276
29MP0005174_abnormal_tail_pigmentation1.57062962
30MP0006082_CNS_inflammation1.55147340
31MP0001542_abnormal_bone_strength1.51930573
32MP0002909_abnormal_adrenal_gland1.50453549
33MP0001486_abnormal_startle_reflex1.40538646
34MP0002837_dystrophic_cardiac_calcinosis1.40100624
35MP0002734_abnormal_mechanical_nocicepti1.37992474
36MP0002733_abnormal_thermal_nociception1.37450387
37MP0001501_abnormal_sleep_pattern1.37330722
38MP0003191_abnormal_cellular_cholesterol1.37187414
39MP0003879_abnormal_hair_cell1.36588497
40MP0002735_abnormal_chemical_nociception1.30115657
41MP0002822_catalepsy1.29738544
42MP0003123_paternal_imprinting1.27595413
43MP0006036_abnormal_mitochondrial_physio1.27354506
44MP0002148_abnormal_hypersensitivity_rea1.26457023
45MP0003011_delayed_dark_adaptation1.24684361
46MP0000750_abnormal_muscle_regeneration1.24414667
47MP0000604_amyloidosis1.23979172
48MP0002332_abnormal_exercise_endurance1.23347202
49MP0000920_abnormal_myelination1.22774769
50MP0003136_yellow_coat_color1.21413033
51MP0003633_abnormal_nervous_system1.20223501
52MP0003436_decreased_susceptibility_to1.19371052
53MP0001756_abnormal_urination1.17450108
54MP0005551_abnormal_eye_electrophysiolog1.16813831
55MP0006276_abnormal_autonomic_nervous1.16610939
56MP0002067_abnormal_sensory_capabilities1.14336873
57MP0002638_abnormal_pupillary_reflex1.11706369
58MP0009780_abnormal_chondrocyte_physiolo1.05848484
59MP0002229_neurodegeneration1.04552230
60MP0002557_abnormal_social/conspecific_i1.04444913
61MP0005671_abnormal_response_to1.04069184
62MP0010386_abnormal_urinary_bladder1.04031482
63MP0008569_lethality_at_weaning1.03048306
64MP0005535_abnormal_body_temperature1.01809559
65MP0003195_calcinosis1.01043700
66MP0008874_decreased_physiological_sensi0.98530337
67MP0008260_abnormal_autophagy0.98392325
68MP0005464_abnormal_platelet_physiology0.98293646
69MP0005084_abnormal_gallbladder_morpholo0.94780613
70MP0005166_decreased_susceptibility_to0.94104234
71MP0005386_behavior/neurological_phenoty0.93291759
72MP0004924_abnormal_behavior0.93291759
73MP0003690_abnormal_glial_cell0.92905614
74MP0009785_altered_susceptibility_to0.92398853
75MP0004142_abnormal_muscle_tone0.91645100
76MP0003724_increased_susceptibility_to0.91247309
77MP0002090_abnormal_vision0.90701781
78MP0005000_abnormal_immune_tolerance0.89728241
79MP0001984_abnormal_olfaction0.89028278
80MP0003631_nervous_system_phenotype0.88228325
81MP0005584_abnormal_enzyme/coenzyme_acti0.87883656
82MP0005253_abnormal_eye_physiology0.87041253
83MP0002066_abnormal_motor_capabilities/c0.86909009
84MP0004885_abnormal_endolymph0.86789846
85MP0005646_abnormal_pituitary_gland0.84825524
86MP0004811_abnormal_neuron_physiology0.84036596
87MP0009764_decreased_sensitivity_to0.82229165
88MP0005025_abnormal_response_to0.81333408
89MP0002095_abnormal_skin_pigmentation0.80876325
90MP0001529_abnormal_vocalization0.79886030
91MP0000639_abnormal_adrenal_gland0.78762645
92MP0005379_endocrine/exocrine_gland_phen0.78113912
93MP0005332_abnormal_amino_acid0.77523479
94MP0006035_abnormal_mitochondrial_morpho0.77320688
95MP0005165_increased_susceptibility_to0.76968214
96MP0008875_abnormal_xenobiotic_pharmacok0.76021640
97MP0002419_abnormal_innate_immunity0.75958244
98MP0002693_abnormal_pancreas_physiology0.75801832
99MP0005167_abnormal_blood-brain_barrier0.74793757
100MP0005083_abnormal_biliary_tract0.74309350

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycosphingolipid metabolism (HP:0004343)3.90192938
2Abnormality of glycolipid metabolism (HP:0010969)3.90192938
3Abnormality of liposaccharide metabolism (HP:0010968)3.90192938
4Mitochondrial inheritance (HP:0001427)3.59479568
5Hepatocellular necrosis (HP:0001404)3.49491693
6Supranuclear gaze palsy (HP:0000605)3.48119262
7Acute necrotizing encephalopathy (HP:0006965)3.29434195
8Abnormal mitochondria in muscle tissue (HP:0008316)3.18304227
9Hepatic necrosis (HP:0002605)3.17461606
10Progressive macrocephaly (HP:0004481)3.01787857
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.98650751
12Decreased activity of mitochondrial respiratory chain (HP:0008972)2.98650751
13Myokymia (HP:0002411)2.94814276
14Dysostosis multiplex (HP:0000943)2.94185924
15Increased CSF lactate (HP:0002490)2.87135103
16Renal Fanconi syndrome (HP:0001994)2.86182127
17Delusions (HP:0000746)2.71611640
18Polyphagia (HP:0002591)2.71443259
19Progressive neurologic deterioration (HP:0002344)2.70685140
20Mutism (HP:0002300)2.67649698
21Retinal dysplasia (HP:0007973)2.64077251
22Abnormality of mucopolysaccharide metabolism (HP:0011020)2.62252173
23Abnormality of polysaccharide metabolism (HP:0011012)2.62252173
24Abnormality of glycosaminoglycan metabolism (HP:0004371)2.62252173
25Hand muscle atrophy (HP:0009130)2.61348444
26Hypokinesia (HP:0002375)2.60034542
27Acute encephalopathy (HP:0006846)2.57928376
28Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.54317551
29Increased intramyocellular lipid droplets (HP:0012240)2.54110596
30Increased hepatocellular lipid droplets (HP:0006565)2.52656280
31Cerebral hypomyelination (HP:0006808)2.45438761
32Diplopia (HP:0000651)2.45398998
33Abnormality of binocular vision (HP:0011514)2.45398998
34Upper limb muscle weakness (HP:0003484)2.45203804
35Vacuolated lymphocytes (HP:0001922)2.45022066
36Prolonged neonatal jaundice (HP:0006579)2.40455312
37Urinary glycosaminoglycan excretion (HP:0003541)2.33702547
38Mucopolysacchariduria (HP:0008155)2.33702547
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.33102306
40Retinal atrophy (HP:0001105)2.31065884
41Emotional lability (HP:0000712)2.30549462
42Neurofibrillary tangles (HP:0002185)2.29114131
43Tongue fasciculations (HP:0001308)2.28642218
44Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.27198349
45Decreased electroretinogram (ERG) amplitude (HP:0000654)2.26378039
46Lipid accumulation in hepatocytes (HP:0006561)2.24378143
47Loss of speech (HP:0002371)2.23506941
48Testicular atrophy (HP:0000029)2.22839152
49Neuronal loss in central nervous system (HP:0002529)2.22461479
50Hemiparesis (HP:0001269)2.21805581
51Increased muscle lipid content (HP:0009058)2.21354057
52Axonal loss (HP:0003447)2.20217722
53Exertional dyspnea (HP:0002875)2.20208365
54Cholecystitis (HP:0001082)2.16988067
55Abnormal gallbladder physiology (HP:0012438)2.16988067
56Action tremor (HP:0002345)2.14804697
57Distal upper limb amyotrophy (HP:0007149)2.13759873
58Upper limb amyotrophy (HP:0009129)2.13759873
59Ketoacidosis (HP:0001993)2.12210010
60Progressive microcephaly (HP:0000253)2.10075195
61Lactic acidosis (HP:0003128)2.09352339
62Petechiae (HP:0000967)2.08308789
63Respiratory failure (HP:0002878)2.07967086
64Diminished movement (HP:0002374)2.06945189
65Absent speech (HP:0001344)2.06884370
66Visual hallucinations (HP:0002367)2.06767391
67Akinesia (HP:0002304)2.06497532
68Abnormal eating behavior (HP:0100738)2.04126061
69Opisthotonus (HP:0002179)2.02525962
70Intention tremor (HP:0002080)2.02004227
71Amyloidosis (HP:0011034)2.01977511
72Exercise intolerance (HP:0003546)2.01782194
73Muscle fibrillation (HP:0010546)2.01659930
74Abnormality of aromatic amino acid family metabolism (HP:0004338)2.01348739
75Ocular albinism (HP:0001107)2.00043409
76Severe muscular hypotonia (HP:0006829)1.95203067
77Congenital stationary night blindness (HP:0007642)1.93048293
78Elevated erythrocyte sedimentation rate (HP:0003565)1.92790569
79Focal dystonia (HP:0004373)1.92128308
80Abnormality of macrophages (HP:0004311)1.92018177
81Albinism (HP:0001022)1.91682822
82Type I transferrin isoform profile (HP:0003642)1.91209783
83Focal motor seizures (HP:0011153)1.89160455
84Diminished motivation (HP:0000745)1.88379198
85Increased cerebral lipofuscin (HP:0011813)1.87540288
86Dysautonomia (HP:0002459)1.87010409
87Myoclonus (HP:0001336)1.86680761
88Epileptiform EEG discharges (HP:0011182)1.85706183
89Hyperthyroidism (HP:0000836)1.83493991
90EEG with generalized epileptiform discharges (HP:0011198)1.83438566
91Epileptic encephalopathy (HP:0200134)1.82397205
92Agitation (HP:0000713)1.81868813
93Ankle clonus (HP:0011448)1.81794551
94Tetraplegia (HP:0002445)1.81755185
95Nuclear cataract (HP:0100018)1.81068278
96Increased serum lactate (HP:0002151)1.80263097
97Adrenal hypoplasia (HP:0000835)1.80004078
98Apathy (HP:0000741)1.79744461
99Iris hypopigmentation (HP:0007730)1.78675256
1003-Methylglutaconic aciduria (HP:0003535)1.77352068

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK14.19121595
2TESK23.74336860
3LIMK13.63657027
4DAPK22.46253308
5ARAF2.43382194
6PAK62.21497956
7PIM22.14099069
8NME22.06782848
9DAPK11.97294090
10MAP3K111.95252443
11GRK51.94663861
12MAP3K121.67354451
13MAP2K71.66684449
14BCKDK1.65350250
15LMTK21.62082371
16CSNK1G31.61208826
17SIK31.58287677
18PHKG21.53628460
19PHKG11.53628460
20VRK21.52242687
21PRKD31.50199029
22STK161.49437819
23CSNK1G21.46354992
24TAOK21.38158082
25TBK11.37504968
26GRK71.35312468
27CSNK1A1L1.31717725
28EPHA41.29090671
29MARK11.28214967
30ABL21.23504639
31MAP4K21.21118925
32PINK11.17247080
33MAPKAPK31.16378803
34SIK21.15346288
35NTRK31.11190062
36MINK11.07054137
37PTK2B1.05982222
38DAPK31.04864381
39IRAK31.04706251
40ERN11.04406501
41PRKD21.03390692
42PLK20.98596853
43PAK30.93108642
44EPHB10.92792509
45KDR0.91652591
46CSNK1G10.91345413
47FRK0.89995840
48MAPK130.89627539
49ADRBK20.89457237
50MAP2K60.87815973
51CAMKK20.87309717
52MAP3K40.85072242
53MOS0.81504808
54TRIM280.79611823
55BLK0.78766117
56MAP3K30.78500531
57CDK140.77079637
58GRK60.75753550
59PKN10.74346055
60TNK20.74273798
61RIPK40.70987961
62HIPK20.70620268
63TXK0.69719725
64IKBKB0.69389681
65PAK10.69157155
66CAMK2G0.68106681
67CCNB10.68009368
68PRKCG0.66615014
69ADRBK10.65685702
70CDK180.63879160
71UHMK10.63388700
72IKBKE0.62918488
73IRAK20.62713504
74PRKCI0.62677901
75CAMK2D0.62607675
76CDK50.60907620
77CAMKK10.60813950
78CDK150.60536662
79TLK10.60505899
80ZAP700.60442929
81MYLK0.60055517
82PRKD10.58785430
83CDK11A0.58269275
84STK380.57224813
85EPHA30.56360163
86GRK10.55710754
87AURKA0.55029812
88BRAF0.53889818
89BMPR20.53742628
90MAP4K10.53531110
91CAMK2A0.51365682
92TAOK10.50865720
93FER0.50741471
94CDK190.49467406
95CAMK2B0.45224924
96MAP3K10.43620970
97ILK0.42829639
98MARK30.42506890
99TAOK30.41105954
100MAPK120.37607462

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.88645346
2Synaptic vesicle cycle_Homo sapiens_hsa047213.81695821
3Collecting duct acid secretion_Homo sapiens_hsa049663.41168086
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.40180540
5Parkinsons disease_Homo sapiens_hsa050122.70213134
6Vibrio cholerae infection_Homo sapiens_hsa051102.61196280
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.55735145
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.36909961
9SNARE interactions in vesicular transport_Homo sapiens_hsa041302.26503113
10Sulfur relay system_Homo sapiens_hsa041222.24427930
11Alzheimers disease_Homo sapiens_hsa050102.22207745
12Lysosome_Homo sapiens_hsa041422.15042771
13Other glycan degradation_Homo sapiens_hsa005111.99327928
14Nicotine addiction_Homo sapiens_hsa050331.85893963
15Fatty acid elongation_Homo sapiens_hsa000621.79122993
16Folate biosynthesis_Homo sapiens_hsa007901.73404975
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.68785983
18Proteasome_Homo sapiens_hsa030501.67531709
19Huntingtons disease_Homo sapiens_hsa050161.61509993
20Rheumatoid arthritis_Homo sapiens_hsa053231.60194800
21GABAergic synapse_Homo sapiens_hsa047271.53927238
22Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.53480359
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.50074810
24Insulin secretion_Homo sapiens_hsa049111.49827972
25Morphine addiction_Homo sapiens_hsa050321.42210030
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36496311
27Cardiac muscle contraction_Homo sapiens_hsa042601.35742587
28Salivary secretion_Homo sapiens_hsa049701.34733404
29Regulation of autophagy_Homo sapiens_hsa041401.26404991
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.23327810
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.23289585
32Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.22287493
33Amphetamine addiction_Homo sapiens_hsa050311.20903110
34Phagosome_Homo sapiens_hsa041451.20484748
35Protein export_Homo sapiens_hsa030601.19492763
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17850773
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16255796
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.15552750
39Circadian entrainment_Homo sapiens_hsa047131.14236892
40Dopaminergic synapse_Homo sapiens_hsa047281.12804791
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06762163
42Cocaine addiction_Homo sapiens_hsa050301.06598686
43Endocytosis_Homo sapiens_hsa041441.03782214
44Sulfur metabolism_Homo sapiens_hsa009201.00460674
45Type I diabetes mellitus_Homo sapiens_hsa049401.00265704
46Fructose and mannose metabolism_Homo sapiens_hsa000510.94092343
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92791924
48Glutamatergic synapse_Homo sapiens_hsa047240.91697460
49RNA polymerase_Homo sapiens_hsa030200.90889934
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86194134
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.83291924
52Salmonella infection_Homo sapiens_hsa051320.82610333
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80391946
54Shigellosis_Homo sapiens_hsa051310.79936177
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.76406409
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76034235
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72545260
58Sphingolipid metabolism_Homo sapiens_hsa006000.71212943
59N-Glycan biosynthesis_Homo sapiens_hsa005100.70394944
60Galactose metabolism_Homo sapiens_hsa000520.68048078
61Phototransduction_Homo sapiens_hsa047440.67298064
62Glutathione metabolism_Homo sapiens_hsa004800.66386558
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65799506
64Gastric acid secretion_Homo sapiens_hsa049710.65454990
65Tuberculosis_Homo sapiens_hsa051520.61725083
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56315426
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54947050
68Long-term potentiation_Homo sapiens_hsa047200.52132945
69Calcium signaling pathway_Homo sapiens_hsa040200.51522731
70Peroxisome_Homo sapiens_hsa041460.48440763
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47666392
72Pertussis_Homo sapiens_hsa051330.47659266
73Metabolic pathways_Homo sapiens_hsa011000.47540435
74Pyrimidine metabolism_Homo sapiens_hsa002400.45045901
75Serotonergic synapse_Homo sapiens_hsa047260.43202232
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38112518
77Cholinergic synapse_Homo sapiens_hsa047250.37578932
78Mineral absorption_Homo sapiens_hsa049780.36635407
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.36335690
80Taste transduction_Homo sapiens_hsa047420.34939094
81Graft-versus-host disease_Homo sapiens_hsa053320.32405703
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31782923
83Pentose phosphate pathway_Homo sapiens_hsa000300.31247599
84Renin secretion_Homo sapiens_hsa049240.31064742
85Long-term depression_Homo sapiens_hsa047300.30885079
86Ether lipid metabolism_Homo sapiens_hsa005650.30846304
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30153606
88Oxytocin signaling pathway_Homo sapiens_hsa049210.29695819
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29432738
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.29162289
91Butanoate metabolism_Homo sapiens_hsa006500.28847099
92Osteoclast differentiation_Homo sapiens_hsa043800.27521608
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27161644
94Alcoholism_Homo sapiens_hsa050340.27093576
95Allograft rejection_Homo sapiens_hsa053300.26941320
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.26814398
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26783402
98Primary immunodeficiency_Homo sapiens_hsa053400.24933071
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24011196
100Legionellosis_Homo sapiens_hsa051340.23605583

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