C5ORF58

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.26560394
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.26560394
3positive regulation of gamma-delta T cell activation (GO:0046645)5.09033985
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.04020689
5regulation of B cell receptor signaling pathway (GO:0050855)4.61286640
6positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.56242953
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.52981591
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.52981591
9modulation by symbiont of host immune response (GO:0052553)4.52981591
10positive regulation by symbiont of host defense response (GO:0052509)4.52981591
11modulation by symbiont of host defense response (GO:0052031)4.52981591
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.52981591
13detection of molecule of bacterial origin (GO:0032490)4.26600622
14response to peptidoglycan (GO:0032494)4.25914601
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.15200012
16cellular extravasation (GO:0045123)4.05551952
17regulation of gamma-delta T cell activation (GO:0046643)3.96977707
18negative regulation of interleukin-12 production (GO:0032695)3.95073581
19microglial cell activation (GO:0001774)3.86828695
20macrophage activation involved in immune response (GO:0002281)3.86775962
21neutrophil activation involved in immune response (GO:0002283)3.86273253
22regulation of gamma-delta T cell differentiation (GO:0045586)3.82783764
23protein targeting to Golgi (GO:0000042)3.78792620
24negative regulation of T cell mediated immunity (GO:0002710)3.77769121
25establishment of protein localization to Golgi (GO:0072600)3.68922712
26regulation of interferon-beta biosynthetic process (GO:0045357)3.65284135
27neutrophil activation (GO:0042119)3.60794362
28negative regulation of lymphocyte mediated immunity (GO:0002707)3.60469927
29response to interleukin-15 (GO:0070672)3.49717018
30neutrophil mediated immunity (GO:0002446)3.46935882
31defense response to protozoan (GO:0042832)3.45788001
32retrograde transport, vesicle recycling within Golgi (GO:0000301)3.45158639
33single strand break repair (GO:0000012)3.44255076
34histone H3-K36 demethylation (GO:0070544)3.43596514
35detection of other organism (GO:0098543)3.41598702
36cellular response to interleukin-15 (GO:0071350)3.41052765
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.35906625
38response to host immune response (GO:0052572)3.35906625
39detection of external biotic stimulus (GO:0098581)3.35291686
40sperm motility (GO:0030317)3.30605892
41histone H3-K9 demethylation (GO:0033169)3.27467251
42granulocyte activation (GO:0036230)3.27378246
43myeloid cell activation involved in immune response (GO:0002275)3.22953465
44histone mRNA catabolic process (GO:0071044)3.20146016
45macrophage activation (GO:0042116)3.19539604
46regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.18420133
47regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.15808446
48myeloid leukocyte mediated immunity (GO:0002444)3.10719784
49response to protozoan (GO:0001562)3.08918171
50regulation of interleukin-12 biosynthetic process (GO:0045075)3.08035385
51negative T cell selection (GO:0043383)3.07437142
52negative regulation of cAMP-mediated signaling (GO:0043951)3.06017081
53negative thymic T cell selection (GO:0045060)3.04473800
54leukocyte aggregation (GO:0070486)3.02239590
55positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.02032031
56detection of biotic stimulus (GO:0009595)3.01799157
57regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.97652152
58negative regulation of inclusion body assembly (GO:0090084)2.96985916
59positive T cell selection (GO:0043368)2.93591571
60positive regulation of granulocyte differentiation (GO:0030854)2.92224363
61negative regulation of interleukin-1 beta production (GO:0032691)2.91465318
62regulation of interleukin-6 biosynthetic process (GO:0045408)2.90013171
63response to host (GO:0075136)2.88634045
64response to host defenses (GO:0052200)2.88634045
65response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.88634045
66DNA methylation involved in gamete generation (GO:0043046)2.87242813
67respiratory burst (GO:0045730)2.87142835
68response to muramyl dipeptide (GO:0032495)2.85412300
69negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.85190015
70acrosome reaction (GO:0007340)2.84933195
71negative regulation of leukocyte mediated immunity (GO:0002704)2.84245515
72male meiosis I (GO:0007141)2.84102162
73interferon-gamma production (GO:0032609)2.82929949
74B cell receptor signaling pathway (GO:0050853)2.82569676
75regulation of memory T cell differentiation (GO:0043380)2.82556312
76mast cell activation (GO:0045576)2.81493825
77positive thymic T cell selection (GO:0045059)2.80533653
78detection of bacterium (GO:0016045)2.79612719
79positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.78501649
80positive regulation of toll-like receptor signaling pathway (GO:0034123)2.75088669
81negative regulation of adaptive immune response (GO:0002820)2.73259477
82negative regulation of interleukin-1 production (GO:0032692)2.73250337
83tyrosine phosphorylation of STAT protein (GO:0007260)2.71694180
84cellular response to type I interferon (GO:0071357)2.71394999
85type I interferon signaling pathway (GO:0060337)2.71394999
86protein K48-linked deubiquitination (GO:0071108)2.69760145
87fusion of sperm to egg plasma membrane (GO:0007342)2.69724554
88positive regulation of B cell differentiation (GO:0045579)2.69456965
89cilium or flagellum-dependent cell motility (GO:0001539)2.68912220
90positive regulation of mast cell activation (GO:0033005)2.68176365
91regulation of T cell mediated cytotoxicity (GO:0001914)2.67706108
92positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.67528502
93regulation of B cell differentiation (GO:0045577)2.67248106
94regulation of meiosis I (GO:0060631)2.67246204
95regulation of alpha-beta T cell proliferation (GO:0046640)2.66570623
96response to type I interferon (GO:0034340)2.66418108
97leukocyte degranulation (GO:0043299)2.64789736
98immunoglobulin mediated immune response (GO:0016064)2.63708003
99lipopolysaccharide-mediated signaling pathway (GO:0031663)2.62807264
100piRNA metabolic process (GO:0034587)2.62634131

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.50241004
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.36060864
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.01206212
4EZH2_22144423_ChIP-Seq_EOC_Human3.63128326
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.55804486
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.48683596
7RUNX_20019798_ChIP-Seq_JUKART_Human3.33338092
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.01690855
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.79570531
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.70563357
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.61555071
12MYB_26560356_Chip-Seq_TH2_Human2.52994377
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.38323860
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.30038507
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.26908129
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.17166140
17POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.11023119
18TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11023119
19VDR_24787735_ChIP-Seq_THP-1_Human2.05662865
20MYB_26560356_Chip-Seq_TH1_Human1.98255530
21GATA3_27048872_Chip-Seq_THYMUS_Human1.97787157
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.95107818
23VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.90622563
24MYB_21317192_ChIP-Seq_ERMYB_Mouse1.89006824
25SCL_19346495_ChIP-Seq_HPC-7_Human1.85902266
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.85254942
27SPI1_23547873_ChIP-Seq_NB4_Human1.77284236
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75392671
29SPI1_23127762_ChIP-Seq_K562_Human1.72981968
30VDR_24763502_ChIP-Seq_THP-1_Human1.67654796
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62648044
32GATA3_26560356_Chip-Seq_TH2_Human1.61754434
33ER_23166858_ChIP-Seq_MCF-7_Human1.59846557
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.59677319
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.59635850
36MAF_26560356_Chip-Seq_TH1_Human1.48621782
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43273455
38PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38111172
39SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37648225
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35716782
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35532725
42UTX_26944678_Chip-Seq_JUKART_Human1.35155898
43GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34201236
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33994071
45CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.32120299
46KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.31105622
47* PRDM14_20953172_ChIP-Seq_ESCs_Human1.29162340
48SMRT_27268052_Chip-Seq_Bcells_Human1.28764902
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25880439
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.25056830
51CBP_20019798_ChIP-Seq_JUKART_Human1.18108206
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18108206
53SALL4_22934838_ChIP-ChIP_CD34+_Human1.11512633
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.10725469
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08952754
56RUNX1_22412390_ChIP-Seq_EML_Mouse1.08606485
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07773383
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06039841
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05722663
60GATA1_19941826_ChIP-Seq_K562_Human1.04542446
61* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.02622749
62PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02603624
63* NANOG_20526341_ChIP-Seq_ESCs_Human1.01672961
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01127712
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.00713404
66GATA1_19941827_ChIP-Seq_MEL86_Mouse1.00682064
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00645162
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99439031
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98625601
70LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96113566
71NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95546415
72PU_27001747_Chip-Seq_BMDM_Mouse0.95351828
73ZNF274_21170338_ChIP-Seq_K562_Hela0.94648639
74GATA3_26560356_Chip-Seq_TH1_Human0.94369836
75WDR5_24793694_ChIP-Seq_LNCAP_Human0.93917760
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93487429
77TAF15_26573619_Chip-Seq_HEK293_Human0.91263540
78FLI1_21867929_ChIP-Seq_TH2_Mouse0.91116464
79* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89997489
80CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88560538
81TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87468957
82MAF_26560356_Chip-Seq_TH2_Human0.86683944
83* SMAD4_21741376_ChIP-Seq_EPCs_Human0.86231132
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.85918179
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85151630
86KDM2B_26808549_Chip-Seq_REH_Human0.84072854
87OCT1_27270436_Chip-Seq_PROSTATE_Human0.83098602
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.83084375
89* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82733407
90RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82732446
91TCF4_23295773_ChIP-Seq_U87_Human0.81745102
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.81414581
93GATA2_22383799_ChIP-Seq_G1ME_Mouse0.79805614
94STAT3_23295773_ChIP-Seq_U87_Human0.78134244
95AR_21572438_ChIP-Seq_LNCaP_Human0.78104618
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77696313
97GATA2_19941826_ChIP-Seq_K562_Human0.77570524
98STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.77444165
99BCAT_22108803_ChIP-Seq_LS180_Human0.76988454
100P300_19829295_ChIP-Seq_ESCs_Human0.75410501

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.16596312
2MP0003303_peritoneal_inflammation3.64940816
3MP0000569_abnormal_digit_pigmentation3.58539752
4MP0001835_abnormal_antigen_presentation3.02546285
5MP0005410_abnormal_fertilization3.02345234
6MP0003436_decreased_susceptibility_to2.93322015
7MP0008057_abnormal_DNA_replication2.90890479
8MP0002822_catalepsy2.77963387
9MP0008877_abnormal_DNA_methylation2.75665325
10MP0005671_abnormal_response_to2.75416218
11MP0001800_abnormal_humoral_immune2.57343818
12MP0003763_abnormal_thymus_physiology2.46583645
13MP0002723_abnormal_immune_serum2.39667994
14MP0005000_abnormal_immune_tolerance2.29646928
15MP0002419_abnormal_innate_immunity2.26880536
16MP0009785_altered_susceptibility_to2.24988401
17MP0005025_abnormal_response_to2.15132445
18MP0006082_CNS_inflammation2.15070019
19MP0005310_abnormal_salivary_gland2.14253797
20MP0002420_abnormal_adaptive_immunity2.13083329
21MP0000685_abnormal_immune_system2.10749156
22MP0001819_abnormal_immune_cell2.08796235
23MP0002452_abnormal_antigen_presenting2.08380851
24MP0002148_abnormal_hypersensitivity_rea2.06892565
25MP0001790_abnormal_immune_system1.95584217
26MP0005387_immune_system_phenotype1.95584217
27MP0009764_decreased_sensitivity_to1.90439125
28MP0002398_abnormal_bone_marrow1.84633804
29MP0003828_pulmonary_edema1.77639484
30MP0005464_abnormal_platelet_physiology1.74116981
31MP0001984_abnormal_olfaction1.69500248
32MP0009278_abnormal_bone_marrow1.68673577
33MP0000716_abnormal_immune_system1.68411711
34MP0003787_abnormal_imprinting1.67454036
35MP0003183_abnormal_peptide_metabolism1.62572429
36MP0002405_respiratory_system_inflammati1.62455128
37MP0002132_abnormal_respiratory_system1.61951707
38MP0008260_abnormal_autophagy1.58461260
39MP0002722_abnormal_immune_system1.52958513
40MP0003698_abnormal_male_reproductive1.48195288
41MP0000703_abnormal_thymus_morphology1.45331929
42MP0001929_abnormal_gametogenesis1.43306090
43MP0005075_abnormal_melanosome_morpholog1.43144090
44MP0000689_abnormal_spleen_morphology1.42999080
45MP0005451_abnormal_body_composition1.41072628
46MP0002332_abnormal_exercise_endurance1.36725283
47MP0000015_abnormal_ear_pigmentation1.34635680
48MP0000465_gastrointestinal_hemorrhage1.31902646
49MP0001845_abnormal_inflammatory_respons1.31560940
50MP0002429_abnormal_blood_cell1.29599431
51MP0003646_muscle_fatigue1.27203120
52MP0004381_abnormal_hair_follicle1.26073439
53MP0009333_abnormal_splenocyte_physiolog1.25974983
54MP0004947_skin_inflammation1.24755888
55MP0003221_abnormal_cardiomyocyte_apopto1.24599695
56MP0001533_abnormal_skeleton_physiology1.24288917
57MP0003656_abnormal_erythrocyte_physiolo1.21388901
58MP0004808_abnormal_hematopoietic_stem1.20880347
59MP0005397_hematopoietic_system_phenotyp1.20524913
60MP0001545_abnormal_hematopoietic_system1.20524913
61MP0004883_abnormal_blood_vessel1.16447337
62MP0002166_altered_tumor_susceptibility1.14052466
63MP0004484_altered_response_of1.09783121
64MP0003300_gastrointestinal_ulcer1.09726477
65MP0010155_abnormal_intestine_physiology1.04244667
66MP0008004_abnormal_stomach_pH1.02239771
67MP0003172_abnormal_lysosome_physiology1.01848629
68MP0002277_abnormal_respiratory_mucosa1.01685457
69MP0002138_abnormal_hepatobiliary_system1.00021032
70MP0008469_abnormal_protein_level0.97945622
71MP0009765_abnormal_xenobiotic_induced0.92991138
72MP0001348_abnormal_lacrimal_gland0.91706570
73MP0001529_abnormal_vocalization0.91327733
74MP0002006_tumorigenesis0.91278339
75MP0003878_abnormal_ear_physiology0.90182272
76MP0005377_hearing/vestibular/ear_phenot0.90182272
77MP0002210_abnormal_sex_determination0.86889985
78MP0003718_maternal_effect0.84374098
79MP0005174_abnormal_tail_pigmentation0.83813296
80MP0002735_abnormal_chemical_nociception0.83439106
81MP0003866_abnormal_defecation0.83330263
82MP0001851_eye_inflammation0.82587072
83MP0005266_abnormal_metabolism0.81144452
84MP0003448_altered_tumor_morphology0.77169537
85MP0005164_abnormal_response_to0.76024079
86MP0000858_altered_metastatic_potential0.72607819
87MP0008874_decreased_physiological_sensi0.71360860
88MP0002998_abnormal_bone_remodeling0.71254420
89MP0002161_abnormal_fertility/fecundity0.71248933
90MP0001853_heart_inflammation0.70649974
91MP0005376_homeostasis/metabolism_phenot0.68374423
92MP0002396_abnormal_hematopoietic_system0.66382224
93MP0000653_abnormal_sex_gland0.66260640
94MP0003045_fibrosis0.65911131
95MP0005167_abnormal_blood-brain_barrier0.65419517
96MP0001145_abnormal_male_reproductive0.65084265
97MP0005645_abnormal_hypothalamus_physiol0.64763846
98MP0008058_abnormal_DNA_repair0.63419612
99MP0005647_abnormal_sex_gland0.63008698
100MP0004142_abnormal_muscle_tone0.61436948

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)5.67515171
2Optic neuritis (HP:0100653)5.67515171
3Recurrent bacterial skin infections (HP:0005406)5.27891008
4Orchitis (HP:0100796)5.27453616
5Myositis (HP:0100614)5.22968030
6T lymphocytopenia (HP:0005403)4.96363732
7Gastrointestinal infarctions (HP:0005244)4.77595636
8Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.75561719
9Stomatitis (HP:0010280)4.70270936
10Abnormality of T cell number (HP:0011839)4.66761503
11Elevated erythrocyte sedimentation rate (HP:0003565)4.55133826
12Recurrent abscess formation (HP:0002722)4.50296051
13Keratoconjunctivitis sicca (HP:0001097)4.32971438
14Keratoconjunctivitis (HP:0001096)4.17840743
15Eczematoid dermatitis (HP:0000976)4.07405709
16Recurrent fungal infections (HP:0002841)3.97431479
17Chronic mucocutaneous candidiasis (HP:0002728)3.86148314
18Recurrent cutaneous fungal infections (HP:0011370)3.86148314
19Recurrent skin infections (HP:0001581)3.82816302
20Abnormality of macrophages (HP:0004311)3.69289469
21Spontaneous hematomas (HP:0007420)3.43274690
22Encephalitis (HP:0002383)3.20556512
23Arterial thrombosis (HP:0004420)3.18412782
24Hemoptysis (HP:0002105)3.14897998
25Mediastinal lymphadenopathy (HP:0100721)3.14869178
26Leukocytosis (HP:0001974)3.11116962
27Recurrent gram-negative bacterial infections (HP:0005420)3.10394563
28Abnormality of T cells (HP:0002843)3.04718131
29Meningitis (HP:0001287)3.04566318
30Peritonitis (HP:0002586)3.02863671
31Gingivitis (HP:0000230)2.98758644
32Vasculitis (HP:0002633)2.97406558
33Chest pain (HP:0100749)2.92196572
34Autoimmune thrombocytopenia (HP:0001973)2.90050454
35Chronic obstructive pulmonary disease (HP:0006510)2.87775891
36Obstructive lung disease (HP:0006536)2.87775891
37Abnormal delayed hypersensitivity skin test (HP:0002963)2.87233101
38Autoimmune hemolytic anemia (HP:0001890)2.77108174
39Acute hepatic failure (HP:0006554)2.76906230
40Gangrene (HP:0100758)2.73679540
41Episodic fever (HP:0001954)2.70856638
42Gingival bleeding (HP:0000225)2.68564541
43Attenuation of retinal blood vessels (HP:0007843)2.62303565
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.61646643
45Absent/shortened dynein arms (HP:0200106)2.61646643
46Recurrent viral infections (HP:0004429)2.57531435
47Hypoplasia of the thymus (HP:0000778)2.57523937
48Pulmonary infiltrates (HP:0002113)2.50933943
49Increased IgE level (HP:0003212)2.46752751
50Anorexia (HP:0002039)2.45643092
51Postural instability (HP:0002172)2.44330760
52Slow saccadic eye movements (HP:0000514)2.42511145
53Pulmonary embolism (HP:0002204)2.38892888
54Keratitis (HP:0000491)2.35286703
55Eosinophilia (HP:0001880)2.34372184
56Amaurosis fugax (HP:0100576)2.33385191
57Inflammation of the large intestine (HP:0002037)2.30726608
58Glomerulopathy (HP:0100820)2.22884930
59Abnormality of eosinophils (HP:0001879)2.22500623
60Urticaria (HP:0001025)2.22012780
61Osteomalacia (HP:0002749)2.19909652
62Polyneuropathy (HP:0001271)2.17834388
63Abnormal spermatogenesis (HP:0008669)2.13396309
64Resting tremor (HP:0002322)2.13268661
65Thyroiditis (HP:0100646)2.09286084
66IgG deficiency (HP:0004315)2.08720280
67Chronic hepatic failure (HP:0100626)2.08057366
68Granulocytopenia (HP:0001913)2.07707271
69Abnormality of the pleura (HP:0002103)2.06830071
70Amyloidosis (HP:0011034)2.03333566
71Neoplasm of the tracheobronchial system (HP:0100552)2.03323029
72Epistaxis (HP:0000421)2.03225478
73Abnormality of the endocardium (HP:0004306)2.02944727
74Abnormality of the peritoneum (HP:0002585)2.01672608
75Vertigo (HP:0002321)2.00980278
76Bony spicule pigmentary retinopathy (HP:0007737)1.99952514
77Gastrointestinal inflammation (HP:0004386)1.99729966
78Truncal obesity (HP:0001956)1.98168728
79Recurrent bronchitis (HP:0002837)1.97077773
80Prolonged bleeding time (HP:0003010)1.94603087
81Abnormality of the fingertips (HP:0001211)1.92395624
82Pustule (HP:0200039)1.91259613
83Severe visual impairment (HP:0001141)1.90508122
84Alveolar cell carcinoma (HP:0006519)1.88207471
85Basal cell carcinoma (HP:0002671)1.87835723
86Abnormality of the columella (HP:0009929)1.86930297
87Abnormality of the vasculature of the conjunctiva (HP:0008054)1.85903171
88Abnormality of B cell number (HP:0010975)1.84506764
89Nasal polyposis (HP:0100582)1.83465048
90Conjunctival telangiectasia (HP:0000524)1.82757006
91Hypochromic anemia (HP:0001931)1.81767490
92Colitis (HP:0002583)1.81549746
93Increased IgM level (HP:0003496)1.80898434
94Joint swelling (HP:0001386)1.79670372
95Hematochezia (HP:0002573)1.79293282
96Stomach cancer (HP:0012126)1.79075393
97Aplasia/Hypoplasia of the thymus (HP:0010515)1.77494368
98Aplasia/Hypoplasia of the earlobes (HP:0009906)1.76412915
99Acne (HP:0001061)1.74635561
100Cheilitis (HP:0100825)1.74216304

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.62503256
2DYRK33.31137594
3IRAK43.21324322
4TXK3.05890531
5IKBKE2.79179259
6MAP4K12.70336593
7BLK2.42806387
8IRAK22.34653734
9MAP3K62.30336708
10IRAK12.21577515
11TYK22.10387351
12CSK1.83139857
13ADRBK21.77159075
14FES1.74144564
15JAK31.73578735
16FGR1.72975107
17MAP3K141.70764312
18ZAP701.70203263
19GRK61.67267231
20EPHB11.67215816
21PLK41.64125802
22GRK71.57826083
23MAP3K131.57040090
24BMPR21.55182464
25SYK1.53437462
26RPS6KA41.51101960
27TAOK31.50414841
28PIK3CG1.42533183
29MAP2K31.42131976
30SGK21.41200878
31BTK1.32313947
32WNK11.28846210
33FRK1.26797086
34KSR21.26042079
35TBK11.22823763
36ITK1.20180138
37MAP3K21.19657815
38NEK61.17882359
39RAF11.17689760
40CAMKK21.15767667
41JAK21.14466516
42TAOK11.13193281
43IKBKB1.12058922
44MARK31.11564815
45HCK1.10374409
46PTK2B1.05699037
47JAK11.05231807
48NLK1.02299690
49PLK21.00916150
50TEC0.98395266
51CAMK1G0.96220981
52LCK0.95797455
53STK380.95452188
54LYN0.94328603
55MAP3K50.93257415
56MAP3K110.91229700
57PDK10.87755703
58PIM10.86479699
59KSR10.86083094
60SGK30.84151078
61MAP3K10.81935522
62CSF1R0.77657443
63TESK20.76933340
64SGK4940.76366505
65SGK2230.76366505
66YES10.75685288
67CAMK40.74336904
68ACVR1B0.73412113
69MAP3K40.70037646
70MAP3K90.69056063
71TNK20.69027418
72STK110.68621356
73MATK0.66272302
74DYRK1A0.65115946
75KIT0.62955790
76PNCK0.62137821
77PRKG10.61249068
78PRPF4B0.61015085
79NTRK30.60454917
80MAP3K30.52333080
81DYRK1B0.52324889
82PRKCQ0.51006319
83SGK10.50804256
84ARAF0.47997134
85NUAK10.47856863
86EGFR0.47810697
87PDPK10.47558239
88TGFBR20.47416783
89RET0.47334940
90FGFR30.47156248
91BRD40.45764377
92GRK50.40808334
93MAP2K40.39206267
94HIPK20.39025039
95CHUK0.37267492
96ZAK0.36233312
97RPS6KC10.34332195
98RPS6KL10.34332195
99TESK10.33427037
100CAMK1D0.32916369

Predicted pathways (KEGG)

RankGene SetZ-score
1NOD-like receptor signaling pathway_Homo sapiens_hsa046212.87015489
2Osteoclast differentiation_Homo sapiens_hsa043802.81116398
3Leishmaniasis_Homo sapiens_hsa051402.56327975
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.20848436
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.19679901
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.13816871
7Primary immunodeficiency_Homo sapiens_hsa053402.10425763
8B cell receptor signaling pathway_Homo sapiens_hsa046622.09358195
9T cell receptor signaling pathway_Homo sapiens_hsa046602.09005551
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.01457309
11Tuberculosis_Homo sapiens_hsa051522.00757284
12Graft-versus-host disease_Homo sapiens_hsa053321.99963570
13Measles_Homo sapiens_hsa051621.93203811
14Legionellosis_Homo sapiens_hsa051341.89682548
15Allograft rejection_Homo sapiens_hsa053301.81162574
16Staphylococcus aureus infection_Homo sapiens_hsa051501.72199437
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.71824683
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.71153810
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.65992984
20Influenza A_Homo sapiens_hsa051641.62874245
21Autoimmune thyroid disease_Homo sapiens_hsa053201.61682885
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.60454278
23TNF signaling pathway_Homo sapiens_hsa046681.58147683
24Acute myeloid leukemia_Homo sapiens_hsa052211.52090245
25Fatty acid biosynthesis_Homo sapiens_hsa000611.48343612
26Hematopoietic cell lineage_Homo sapiens_hsa046401.48195265
27Chemokine signaling pathway_Homo sapiens_hsa040621.46550336
28Malaria_Homo sapiens_hsa051441.45099864
29Nicotine addiction_Homo sapiens_hsa050331.44657622
30Antigen processing and presentation_Homo sapiens_hsa046121.44540144
31Type I diabetes mellitus_Homo sapiens_hsa049401.38435076
32Hepatitis B_Homo sapiens_hsa051611.28299154
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28197595
34Herpes simplex infection_Homo sapiens_hsa051681.27520789
35Dorso-ventral axis formation_Homo sapiens_hsa043201.25886067
36Toxoplasmosis_Homo sapiens_hsa051451.24403383
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18395921
38VEGF signaling pathway_Homo sapiens_hsa043701.13427248
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13155112
40Pertussis_Homo sapiens_hsa051331.05602473
41Prolactin signaling pathway_Homo sapiens_hsa049171.05345847
42Non-small cell lung cancer_Homo sapiens_hsa052231.03566456
43Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98013469
44Type II diabetes mellitus_Homo sapiens_hsa049300.97345919
45Regulation of autophagy_Homo sapiens_hsa041400.94747262
46Platelet activation_Homo sapiens_hsa046110.94352077
47Morphine addiction_Homo sapiens_hsa050320.93093662
48Rheumatoid arthritis_Homo sapiens_hsa053230.90952901
49Apoptosis_Homo sapiens_hsa042100.90695136
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.88233313
51Olfactory transduction_Homo sapiens_hsa047400.86210775
52FoxO signaling pathway_Homo sapiens_hsa040680.85300782
53Inositol phosphate metabolism_Homo sapiens_hsa005620.84592627
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83502867
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82390971
56Pancreatic cancer_Homo sapiens_hsa052120.82242653
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.81990330
58Viral myocarditis_Homo sapiens_hsa054160.81974314
59Hepatitis C_Homo sapiens_hsa051600.81420482
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79571427
61African trypanosomiasis_Homo sapiens_hsa051430.76223705
62Cholinergic synapse_Homo sapiens_hsa047250.73231989
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72690715
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71484620
65Phagosome_Homo sapiens_hsa041450.70723012
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.70532506
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68629084
68Viral carcinogenesis_Homo sapiens_hsa052030.67366682
69MAPK signaling pathway_Homo sapiens_hsa040100.63705565
70Asthma_Homo sapiens_hsa053100.63577478
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63304214
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62557915
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61380965
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.60722487
75Choline metabolism in cancer_Homo sapiens_hsa052310.59094106
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56351576
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56227206
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56098349
79Salmonella infection_Homo sapiens_hsa051320.55410151
80Chronic myeloid leukemia_Homo sapiens_hsa052200.55164315
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55100024
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.54907049
83mTOR signaling pathway_Homo sapiens_hsa041500.54490824
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54379325
85Long-term potentiation_Homo sapiens_hsa047200.53198234
86Epstein-Barr virus infection_Homo sapiens_hsa051690.52350154
87Renal cell carcinoma_Homo sapiens_hsa052110.51600583
88Shigellosis_Homo sapiens_hsa051310.50549850
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49728370
90Insulin resistance_Homo sapiens_hsa049310.49727824
91HIF-1 signaling pathway_Homo sapiens_hsa040660.49382393
92Endometrial cancer_Homo sapiens_hsa052130.49175838
93Colorectal cancer_Homo sapiens_hsa052100.48259692
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.47504438
95Taste transduction_Homo sapiens_hsa047420.46759266
96Prostate cancer_Homo sapiens_hsa052150.45173611
97mRNA surveillance pathway_Homo sapiens_hsa030150.43889495
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43843581
99cAMP signaling pathway_Homo sapiens_hsa040240.43664111
100ErbB signaling pathway_Homo sapiens_hsa040120.42266876

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