C5ORF47

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of meiosis I (GO:0060631)9.94408668
2male meiosis (GO:0007140)9.60018595
3synaptonemal complex assembly (GO:0007130)9.44107709
4gonadal mesoderm development (GO:0007506)8.92157819
5meiosis I (GO:0007127)8.87072355
6synaptonemal complex organization (GO:0070193)8.62901914
7meiotic nuclear division (GO:0007126)8.18336183
8DNA synthesis involved in DNA repair (GO:0000731)6.85755823
9gene silencing by RNA (GO:0031047)6.85054148
10meiotic cell cycle process (GO:1903046)6.77487075
11resolution of meiotic recombination intermediates (GO:0000712)6.20887370
12sister chromatid cohesion (GO:0007062)6.06696713
13positive regulation of meiosis (GO:0045836)5.93287835
14meiotic chromosome segregation (GO:0045132)5.66843849
15positive regulation of meiotic cell cycle (GO:0051446)5.54412458
16female gamete generation (GO:0007292)5.49137321
17regulation of histone H3-K9 methylation (GO:0051570)5.15090156
18meiotic cell cycle (GO:0051321)5.13109770
19histone H3-K9 demethylation (GO:0033169)5.08750676
20oogenesis (GO:0048477)5.01153647
21reciprocal meiotic recombination (GO:0007131)4.90028222
22reciprocal DNA recombination (GO:0035825)4.90028222
23mitotic sister chromatid cohesion (GO:0007064)4.63384657
24DNA alkylation (GO:0006305)4.57464559
25DNA methylation (GO:0006306)4.57464559
26regulation of meiotic cell cycle (GO:0051445)4.54557277
27gene silencing (GO:0016458)4.18898758
28regulation of meiosis (GO:0040020)4.16269517
29negative regulation of meiosis (GO:0045835)4.01920219
30sex differentiation (GO:0007548)3.97213138
31regulation of DNA endoreduplication (GO:0032875)3.72406867
32negative regulation of gene silencing (GO:0060969)3.68689913
33binding of sperm to zona pellucida (GO:0007339)3.68230545
34germ cell development (GO:0007281)3.57202827
35spermatid development (GO:0007286)3.57065121
36histone exchange (GO:0043486)3.47114638
37DNA methylation or demethylation (GO:0044728)3.39535787
38chromatin remodeling at centromere (GO:0031055)3.36495614
39attachment of spindle microtubules to kinetochore (GO:0008608)3.32149548
40oocyte maturation (GO:0001556)3.30011268
41sperm-egg recognition (GO:0035036)3.29107344
42CENP-A containing nucleosome assembly (GO:0034080)3.26691931
43negative regulation of inclusion body assembly (GO:0090084)3.26520652
44centriole replication (GO:0007099)3.23691567
45negative regulation of meiotic cell cycle (GO:0051447)3.23542218
46histone H3-K36 demethylation (GO:0070544)3.22623612
47proteasome assembly (GO:0043248)3.18908670
48mitotic chromosome condensation (GO:0007076)3.18224767
49centriole assembly (GO:0098534)3.17822741
50male gamete generation (GO:0048232)3.14289390
51spermatogenesis (GO:0007283)3.13680071
52gamete generation (GO:0007276)3.11624837
53fertilization (GO:0009566)3.05359899
54protein localization to chromosome (GO:0034502)3.04882257
55N-terminal protein amino acid acetylation (GO:0006474)2.98389305
56regulation of double-strand break repair via homologous recombination (GO:0010569)2.95529966
57DNA modification (GO:0006304)2.93709780
58nuclear pore complex assembly (GO:0051292)2.91651281
59chromosome organization (GO:0051276)2.90751006
60nuclear division (GO:0000280)2.86516650
61histone H2A acetylation (GO:0043968)2.84234259
62base-excision repair, AP site formation (GO:0006285)2.80260265
63cellular process involved in reproduction in multicellular organism (GO:0022412)2.80017483
64negative regulation of mitotic sister chromatid separation (GO:2000816)2.78210249
65negative regulation of sister chromatid segregation (GO:0033046)2.78210249
66negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.78210249
67negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.78210249
68negative regulation of mitotic sister chromatid segregation (GO:0033048)2.78210249
69mitotic spindle assembly checkpoint (GO:0007094)2.76323047
70DNA biosynthetic process (GO:0071897)2.76304961
71embryonic body morphogenesis (GO:0010172)2.75502202
72regulation of mitotic spindle checkpoint (GO:1903504)2.74850612
73regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.74850612
74nuclear pore organization (GO:0006999)2.72918690
75positive regulation of translational initiation (GO:0045948)2.72179583
76spindle assembly checkpoint (GO:0071173)2.72019691
77acrosome assembly (GO:0001675)2.71743680
78mitotic spindle checkpoint (GO:0071174)2.69066986
79negative regulation of chromosome segregation (GO:0051985)2.69047181
80organelle fission (GO:0048285)2.68127203
81acrosome reaction (GO:0007340)2.62472102
82negative regulation of nuclear division (GO:0051784)2.62461400
83interkinetic nuclear migration (GO:0022027)2.60464931
84histone lysine demethylation (GO:0070076)2.58322240
85negative regulation of DNA-dependent DNA replication (GO:2000104)2.55390741
86spindle checkpoint (GO:0031577)2.55287768
87mitotic metaphase plate congression (GO:0007080)2.54963868
88regulation of mitotic sister chromatid separation (GO:0010965)2.54328602
89regulation of mitotic sister chromatid segregation (GO:0033047)2.54328602
90regulation of sister chromatid segregation (GO:0033045)2.54328602
91cell-cell recognition (GO:0009988)2.53881587
92DNA replication-independent nucleosome organization (GO:0034724)2.50328394
93DNA replication-independent nucleosome assembly (GO:0006336)2.50328394
94nucleus organization (GO:0006997)2.50221953
95regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.49933332
96piRNA metabolic process (GO:0034587)16.9839086
97synapsis (GO:0007129)12.3703306
98DNA methylation involved in gamete generation (GO:0043046)11.5189000
99male meiosis I (GO:0007141)11.0943543
100chromosome organization involved in meiosis (GO:0070192)10.0080015

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.15612507
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.76908997
3ZNF274_21170338_ChIP-Seq_K562_Hela3.96609375
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.29473842
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.06186499
6IGF1R_20145208_ChIP-Seq_DFB_Human2.99376532
7EZH2_22144423_ChIP-Seq_EOC_Human2.89808959
8E2F7_22180533_ChIP-Seq_HELA_Human2.80706159
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.65822619
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.45193621
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.45193621
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.45193621
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31676144
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.21814652
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.19915482
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00244774
17E2F4_17652178_ChIP-ChIP_JURKAT_Human1.99980775
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.97676975
19PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89760394
20CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.85793856
21RNF2_27304074_Chip-Seq_NSC_Mouse1.83107993
22TAF15_26573619_Chip-Seq_HEK293_Human1.81327815
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.80975342
24FUS_26573619_Chip-Seq_HEK293_Human1.76920610
25VDR_22108803_ChIP-Seq_LS180_Human1.76643401
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75615272
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71950917
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65922906
29VDR_23849224_ChIP-Seq_CD4+_Human1.65576243
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64850783
31PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.59957943
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.58272077
33EWS_26573619_Chip-Seq_HEK293_Human1.55877212
34GATA1_26923725_Chip-Seq_HPCs_Mouse1.52847771
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.49835526
36GBX2_23144817_ChIP-Seq_PC3_Human1.48211228
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.46532742
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37846724
39RUNX2_22187159_ChIP-Seq_PCA_Human1.37511718
40BCAT_22108803_ChIP-Seq_LS180_Human1.37299390
41FOXA1_21572438_ChIP-Seq_LNCaP_Human1.36795892
42CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35691113
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35326306
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.32119289
45ER_23166858_ChIP-Seq_MCF-7_Human1.31742136
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30434043
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27826504
48MYC_18940864_ChIP-ChIP_HL60_Human1.27190637
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26985230
50EST1_17652178_ChIP-ChIP_JURKAT_Human1.26369341
51SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.23910937
52RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21995888
53TP53_22573176_ChIP-Seq_HFKS_Human1.20586491
54DCP1A_22483619_ChIP-Seq_HELA_Human1.19678712
55HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19028743
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.18925350
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18925350
58STAT3_23295773_ChIP-Seq_U87_Human1.17385228
59KAP1_22055183_ChIP-Seq_ESCs_Mouse1.15700851
60TCF4_23295773_ChIP-Seq_U87_Human1.14419285
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12877167
62GABP_19822575_ChIP-Seq_HepG2_Human1.11544979
63CBP_20019798_ChIP-Seq_JUKART_Human1.10850897
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10850897
65FOXP3_21729870_ChIP-Seq_TREG_Human1.10174148
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.09866087
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07045299
68HOXB7_26014856_ChIP-Seq_BT474_Human1.06867487
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06187344
70ETS1_20019798_ChIP-Seq_JURKAT_Human1.05432984
71GATA3_26560356_Chip-Seq_TH1_Human1.03944366
72JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.03672077
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03399422
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02913496
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02304064
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.02011264
77FOXH1_21741376_ChIP-Seq_EPCs_Human1.01551795
78CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00878034
79* SMAD4_21741376_ChIP-Seq_EPCs_Human1.00446258
80AR_25329375_ChIP-Seq_VCAP_Human0.99389066
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99312131
82P300_19829295_ChIP-Seq_ESCs_Human0.98194579
83TTF2_22483619_ChIP-Seq_HELA_Human0.97332036
84MYC_18555785_ChIP-Seq_MESCs_Mouse0.97285146
85CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96666118
86ELK1_19687146_ChIP-ChIP_HELA_Human0.94948202
87THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94704982
88PRDM14_20953172_ChIP-Seq_ESCs_Human0.94531620
89E2F1_17053090_ChIP-ChIP_MCF-7_Human0.93666230
90SMAD4_21799915_ChIP-Seq_A2780_Human0.93111718
91YY1_21170310_ChIP-Seq_MESCs_Mouse0.92611793
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91451417
93FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91017493
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90746900
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90746900
96PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90744328
97RUNX1_26923725_Chip-Seq_HPCs_Mouse0.88933022
98EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88197969
99ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87734186
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86008013

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation9.26142173
2MP0002210_abnormal_sex_determination4.49633475
3MP0001929_abnormal_gametogenesis3.97407522
4MP0008058_abnormal_DNA_repair3.81085871
5MP0003718_maternal_effect3.60355941
6MP0010368_abnormal_lymphatic_system3.60342051
7MP0001145_abnormal_male_reproductive3.31404823
8MP0000653_abnormal_sex_gland3.20225698
9MP0003698_abnormal_male_reproductive3.15932480
10MP0002160_abnormal_reproductive_system2.88073183
11MP0003693_abnormal_embryo_hatching2.77509854
12MP0010030_abnormal_orbit_morphology2.43459066
13MP0008057_abnormal_DNA_replication2.33628610
14MP0010094_abnormal_chromosome_stability2.07616034
15MP0002161_abnormal_fertility/fecundity2.00260792
16MP0008789_abnormal_olfactory_epithelium1.91776908
17MP0005499_abnormal_olfactory_system1.88127579
18MP0005394_taste/olfaction_phenotype1.88127579
19MP0005410_abnormal_fertilization1.82969625
20MP0006292_abnormal_olfactory_placode1.78652861
21MP0002139_abnormal_hepatobiliary_system1.74345783
22MP0003183_abnormal_peptide_metabolism1.74078724
23MP0001119_abnormal_female_reproductive1.73018913
24MP0000383_abnormal_hair_follicle1.68060540
25MP0003699_abnormal_female_reproductive1.67868305
26MP0005389_reproductive_system_phenotype1.63720810
27MP0000566_synostosis1.62241627
28MP0003077_abnormal_cell_cycle1.60866317
29MP0005174_abnormal_tail_pigmentation1.52017199
30MP0003111_abnormal_nucleus_morphology1.50799834
31MP0001188_hyperpigmentation1.47522881
32MP0004957_abnormal_blastocyst_morpholog1.44645709
33MP0005395_other_phenotype1.37154001
34MP0008007_abnormal_cellular_replicative1.32771928
35MP0010307_abnormal_tumor_latency1.32354318
36MP0008260_abnormal_autophagy1.27560191
37MP0010678_abnormal_skin_adnexa1.23969933
38MP0003890_abnormal_embryonic-extraembry1.13556370
39MP0001730_embryonic_growth_arrest1.11172383
40MP0003941_abnormal_skin_development1.07377971
41MP0008932_abnormal_embryonic_tissue1.06921845
42MP0004147_increased_porphyrin_level1.05746202
43MP0000015_abnormal_ear_pigmentation1.05495293
44MP0000678_abnormal_parathyroid_gland1.05015147
45MP0002233_abnormal_nose_morphology1.04739100
46MP0003136_yellow_coat_color1.03487514
47MP0003119_abnormal_digestive_system1.01725478
48MP0008004_abnormal_stomach_pH1.01088143
49MP0003786_premature_aging1.00990772
50MP0008995_early_reproductive_senescence0.99718354
51MP0001879_abnormal_lymphatic_vessel0.99434497
52MP0003646_muscle_fatigue0.97067113
53MP0002084_abnormal_developmental_patter0.96853139
54MP0005409_darkened_coat_color0.94938762
55MP0003937_abnormal_limbs/digits/tail_de0.94362129
56MP0003567_abnormal_fetal_cardiomyocyte0.93542510
57MP0004215_abnormal_myocardial_fiber0.90218316
58MP0001177_atelectasis0.89922266
59MP0000631_abnormal_neuroendocrine_gland0.87850209
60MP0005551_abnormal_eye_electrophysiolog0.85149962
61MP0003936_abnormal_reproductive_system0.78488818
62MP0000569_abnormal_digit_pigmentation0.78457923
63MP0001672_abnormal_embryogenesis/_devel0.77411175
64MP0005380_embryogenesis_phenotype0.77411175
65MP0003123_paternal_imprinting0.76061217
66MP0002085_abnormal_embryonic_tissue0.75357221
67MP0002095_abnormal_skin_pigmentation0.72195963
68MP0001697_abnormal_embryo_size0.69762137
69MP0004197_abnormal_fetal_growth/weight/0.69146351
70MP0009703_decreased_birth_body0.66726595
71MP0000778_abnormal_nervous_system0.66155180
72MP0005647_abnormal_sex_gland0.64674068
73MP0006035_abnormal_mitochondrial_morpho0.63882743
74MP0001293_anophthalmia0.62678165
75MP0002638_abnormal_pupillary_reflex0.59885661
76MP0000350_abnormal_cell_proliferation0.58736429
77MP0009379_abnormal_foot_pigmentation0.58027752
78MP0001324_abnormal_eye_pigmentation0.55362872
79MP0000427_abnormal_hair_cycle0.54588848
80MP0000358_abnormal_cell_content/0.52166555
81MP0003861_abnormal_nervous_system0.52163331
82MP0000313_abnormal_cell_death0.51158844
83MP0002067_abnormal_sensory_capabilities0.50834224
84MP0002088_abnormal_embryonic_growth/wei0.50378792
85MP0004924_abnormal_behavior0.50336956
86MP0005386_behavior/neurological_phenoty0.50336956
87MP0001764_abnormal_homeostasis0.50310310
88MP0003984_embryonic_growth_retardation0.49745603
89MP0001984_abnormal_olfaction0.49128676
90MP0002080_prenatal_lethality0.48439682
91MP0003935_abnormal_craniofacial_develop0.46801328
92MP0001486_abnormal_startle_reflex0.45946156
93MP0003186_abnormal_redox_activity0.45529521
94MP0003943_abnormal_hepatobiliary_system0.44053730
95MP0000647_abnormal_sebaceous_gland0.42721255
96MP0002277_abnormal_respiratory_mucosa0.40317895
97MP0009250_abnormal_appendicular_skeleto0.39836048
98MP0003880_abnormal_central_pattern0.39598956
99MP0002796_impaired_skin_barrier0.39257004
100MP0002116_abnormal_craniofacial_bone0.38461649

Predicted human phenotypes

RankGene SetZ-score
1Gonadotropin excess (HP:0000837)5.65451685
2Shoulder girdle muscle weakness (HP:0003547)4.66044144
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.44628713
4Degeneration of the lateral corticospinal tracts (HP:0002314)4.44628713
5Volvulus (HP:0002580)4.27083827
6Azoospermia (HP:0000027)4.16743977
7Oligodactyly (hands) (HP:0001180)4.06877064
8Chromsome breakage (HP:0040012)3.98626479
9Osteomalacia (HP:0002749)3.87095248
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.75208664
11Horizontal nystagmus (HP:0000666)3.73799416
12Rimmed vacuoles (HP:0003805)3.56931192
13Short tibia (HP:0005736)3.49453669
14Abnormality of the corticospinal tract (HP:0002492)3.45546685
15Scotoma (HP:0000575)3.33097180
16Aplasia/Hypoplasia of the tibia (HP:0005772)3.27502771
17Tubulointerstitial nephritis (HP:0001970)3.21417083
18Ectopic kidney (HP:0000086)3.20153044
19Oligodactyly (HP:0012165)3.12867149
20Abnormal spermatogenesis (HP:0008669)3.10867492
21Capillary hemangiomas (HP:0005306)3.08068006
22Facial hemangioma (HP:0000329)2.99990459
23Supernumerary spleens (HP:0009799)2.95043584
24Amyotrophic lateral sclerosis (HP:0007354)2.83772400
25Abnormality of DNA repair (HP:0003254)2.80595776
26Median cleft lip (HP:0000161)2.68901319
27Abnormality of the renal collecting system (HP:0004742)2.65044588
28Lip pit (HP:0100267)2.61301697
29Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.59795046
30Abnormality of the lower motor neuron (HP:0002366)2.56117270
31Abnormality of the labia minora (HP:0012880)2.54737359
32Duodenal stenosis (HP:0100867)2.53490062
33Small intestinal stenosis (HP:0012848)2.53490062
34Enlarged epiphyses (HP:0010580)2.51203739
35Premature ovarian failure (HP:0008209)2.49943225
36Impaired vibration sensation in the lower limbs (HP:0002166)2.45035951
37Spontaneous abortion (HP:0005268)2.42704973
38Abnormal lung lobation (HP:0002101)2.35851425
39Increased nuchal translucency (HP:0010880)2.35006162
40Type II lissencephaly (HP:0007260)2.34744324
41Upper motor neuron abnormality (HP:0002127)2.34145879
42Hypokinesia (HP:0002375)2.32778647
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32097225
44Abnormality of alanine metabolism (HP:0010916)2.32097225
45Hyperalaninemia (HP:0003348)2.32097225
46Duplicated collecting system (HP:0000081)2.26846493
47Abnormality of chromosome stability (HP:0003220)2.26745314
48Bundle branch block (HP:0011710)2.25770421
49Atrophy/Degeneration involving motor neurons (HP:0007373)2.14279812
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.14150444
51Hypoplastic labia majora (HP:0000059)2.13412082
52Non-midline cleft lip (HP:0100335)2.13265823
53Abnormality of abdominal situs (HP:0011620)2.12283160
54Abdominal situs inversus (HP:0003363)2.12283160
55Progressive external ophthalmoplegia (HP:0000590)2.10602897
56Fair hair (HP:0002286)2.07742005
57Horseshoe kidney (HP:0000085)2.06456071
58Abnormality of the phalanges of the hallux (HP:0010057)2.06203304
59Abnormality of the costochondral junction (HP:0000919)2.04071226
60Papillary thyroid carcinoma (HP:0002895)2.03426120
61Abnormality of the duodenum (HP:0002246)2.02840831
62Molar tooth sign on MRI (HP:0002419)1.98817841
63Abnormality of midbrain morphology (HP:0002418)1.98817841
64Hyperglycinuria (HP:0003108)1.97255758
65Meckel diverticulum (HP:0002245)1.93351473
66Preaxial hand polydactyly (HP:0001177)1.92707978
67Intellectual disability, profound (HP:0002187)1.92680772
68Poor eye contact (HP:0000817)1.92075609
69Abnormality of the labia (HP:0000058)1.92026654
70Broad distal phalanx of finger (HP:0009836)1.89819843
71Morphological abnormality of the pyramidal tract (HP:0002062)1.89199040
72Abnormality of the preputium (HP:0100587)1.88642638
73Rhabdomyosarcoma (HP:0002859)1.87977374
74Abnormality of the labia majora (HP:0012881)1.87392819
75Abnormality of cochlea (HP:0000375)1.85439037
76Medial flaring of the eyebrow (HP:0010747)1.83653341
77Limb dystonia (HP:0002451)1.82055673
78Agnosia (HP:0010524)1.80761730
79Astigmatism (HP:0000483)1.79323182
80Infertility (HP:0000789)1.78705436
81Hypoplasia of the uterus (HP:0000013)1.78566326
82Truncal obesity (HP:0001956)1.78096284
83Absent radius (HP:0003974)1.77609147
84Abnormality of chromosome segregation (HP:0002916)1.77500570
85Nephronophthisis (HP:0000090)1.77319488
86Abnormality of the ileum (HP:0001549)1.76531406
87Retinal dysplasia (HP:0007973)1.74895110
88Stenosis of the external auditory canal (HP:0000402)1.73272673
89Nephroblastoma (Wilms tumor) (HP:0002667)1.71825957
90Progressive inability to walk (HP:0002505)1.71426175
91Inappropriate behavior (HP:0000719)1.71157414
92Abnormality of serine family amino acid metabolism (HP:0010894)1.70496969
93Abnormality of glycine metabolism (HP:0010895)1.70496969
94Duplication of thumb phalanx (HP:0009942)1.70361460
95Rickets (HP:0002748)1.70262206
96Congenital primary aphakia (HP:0007707)1.70225834
97Spastic tetraparesis (HP:0001285)1.66910770
98Global brain atrophy (HP:0002283)1.66060104
99Nephrogenic diabetes insipidus (HP:0009806)1.65931029
100Reticulocytopenia (HP:0001896)1.65836372

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK8.06010424
2ACVR1B5.31033805
3CDK194.74206073
4ARAF3.27161430
5MAP3K92.85316717
6WEE12.44872418
7MAP3K132.38999661
8MET2.24851633
9PLK42.22345515
10BRAF2.02943751
11CDK121.88268594
12TTK1.81413516
13NEK91.77401151
14CAMK1G1.71841597
15OXSR11.57662701
16RAF11.56389996
17EPHA41.49792292
18STK391.43792413
19MUSK1.43041978
20KSR21.39246301
21PBK1.35391823
22STK241.34400939
23WNK41.33897658
24PLK11.32439739
25MAPKAPK51.25418693
26NEK61.20582250
27CDC71.20574353
28PLK21.13805401
29TAOK31.13225781
30WNK11.11084301
31TSSK61.07595280
32STK161.00673579
33STK38L1.00286586
34BMPR1B0.99761012
35TYRO30.99512596
36NUAK10.98918630
37TAF10.93277532
38KSR10.92199427
39BRD40.92049236
40ZAK0.91149255
41ATR0.90491781
42PDK20.89791037
43CHEK10.89642896
44ATM0.88561131
45MOS0.84351625
46PTK2B0.83053337
47LIMK10.82416996
48WNK30.81095334
49CDK70.77792258
50STK30.71881233
51MAP3K40.71794107
52BUB10.71336504
53CDK30.66145561
54PASK0.64966593
55MAPK130.63680666
56AURKA0.63109476
57PRKCI0.61041658
58NTRK30.60157003
59MST1R0.59280343
60SGK10.55434998
61RPS6KB10.54958115
62CDK90.54820352
63VRK10.53482967
64EIF2AK30.50529969
65CSF1R0.49632527
66PIM10.48800749
67BMX0.47051809
68CASK0.45136674
69BRSK10.44863226
70PINK10.44842145
71BRSK20.42679513
72CDK20.41869703
73CDK11A0.41300651
74DYRK1A0.32597646
75PRKCG0.32557312
76NEK20.32375894
77PDGFRB0.32282048
78FGR0.31460456
79MAP3K20.31191374
80CDK10.30889289
81PRKCQ0.29454226
82STK380.29450336
83CSNK2A20.28841567
84PRKDC0.28365466
85EGFR0.27951687
86CSNK2A10.27193681
87LATS20.26829292
88CAMK10.26463027
89CSNK1E0.25092005
90CDK140.24281389
91PRKG10.23689546
92TIE10.23447246
93DMPK0.22655566
94CHEK20.22290856
95PLK30.21991291
96RPS6KA10.21705733
97AURKB0.21211535
98MAPK140.20793934
99RET0.20715624
100RPS6KA50.20591499

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043204.82727393
2Basal transcription factors_Homo sapiens_hsa030224.42300374
3Mismatch repair_Homo sapiens_hsa034303.65008232
4Cell cycle_Homo sapiens_hsa041103.29108866
5RNA transport_Homo sapiens_hsa030133.22057066
6Homologous recombination_Homo sapiens_hsa034403.09157083
7Fanconi anemia pathway_Homo sapiens_hsa034603.06129925
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.05347252
9Base excision repair_Homo sapiens_hsa034102.99424961
10Nucleotide excision repair_Homo sapiens_hsa034202.80448888
11DNA replication_Homo sapiens_hsa030302.69751113
12Ubiquitin mediated proteolysis_Homo sapiens_hsa041202.69465648
13Oocyte meiosis_Homo sapiens_hsa041142.67392743
14mRNA surveillance pathway_Homo sapiens_hsa030152.45514044
15Regulation of autophagy_Homo sapiens_hsa041402.42809649
16Non-homologous end-joining_Homo sapiens_hsa034502.38079324
17Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.32606008
18Propanoate metabolism_Homo sapiens_hsa006402.15766891
19RNA degradation_Homo sapiens_hsa030182.12046060
20Protein export_Homo sapiens_hsa030601.77347054
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69896473
22Sulfur relay system_Homo sapiens_hsa041221.57966270
23Selenocompound metabolism_Homo sapiens_hsa004501.52037403
24Folate biosynthesis_Homo sapiens_hsa007901.32253205
25p53 signaling pathway_Homo sapiens_hsa041151.30636180
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28915074
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25306345
28ABC transporters_Homo sapiens_hsa020101.21157682
29Phototransduction_Homo sapiens_hsa047441.13220381
30Vitamin B6 metabolism_Homo sapiens_hsa007501.04138869
31Steroid biosynthesis_Homo sapiens_hsa001001.01502989
32TGF-beta signaling pathway_Homo sapiens_hsa043500.92703653
33beta-Alanine metabolism_Homo sapiens_hsa004100.92599195
34RNA polymerase_Homo sapiens_hsa030200.90996705
35Cysteine and methionine metabolism_Homo sapiens_hsa002700.87444661
36Nicotine addiction_Homo sapiens_hsa050330.79047225
37Tryptophan metabolism_Homo sapiens_hsa003800.76699485
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73496029
39Huntingtons disease_Homo sapiens_hsa050160.73127430
40Tyrosine metabolism_Homo sapiens_hsa003500.69333154
41Pyruvate metabolism_Homo sapiens_hsa006200.69225087
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63814753
43Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61830045
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61220485
45Circadian rhythm_Homo sapiens_hsa047100.60174286
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58800506
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58661698
48Purine metabolism_Homo sapiens_hsa002300.58570542
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52628053
50mTOR signaling pathway_Homo sapiens_hsa041500.52337553
51Pyrimidine metabolism_Homo sapiens_hsa002400.49128193
52N-Glycan biosynthesis_Homo sapiens_hsa005100.45239203
53Retinol metabolism_Homo sapiens_hsa008300.43931676
54Hedgehog signaling pathway_Homo sapiens_hsa043400.42560842
55Serotonergic synapse_Homo sapiens_hsa047260.40759853
56Olfactory transduction_Homo sapiens_hsa047400.40433166
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39593944
58Butanoate metabolism_Homo sapiens_hsa006500.39445828
59Spliceosome_Homo sapiens_hsa030400.38460303
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36502806
61Inositol phosphate metabolism_Homo sapiens_hsa005620.34531307
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34471314
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34419221
64Fatty acid elongation_Homo sapiens_hsa000620.32612848
65Caffeine metabolism_Homo sapiens_hsa002320.32494310
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31950692
67Taste transduction_Homo sapiens_hsa047420.30402280
68Morphine addiction_Homo sapiens_hsa050320.30319463
69Parkinsons disease_Homo sapiens_hsa050120.30266179
70Wnt signaling pathway_Homo sapiens_hsa043100.27464919
71Arginine and proline metabolism_Homo sapiens_hsa003300.26722814
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26500065
73ErbB signaling pathway_Homo sapiens_hsa040120.25992436
74Cholinergic synapse_Homo sapiens_hsa047250.24755153
75HTLV-I infection_Homo sapiens_hsa051660.24271915
76Metabolic pathways_Homo sapiens_hsa011000.23781460
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23767076
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23463818
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.21931466
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19706815
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.19357741
82Long-term depression_Homo sapiens_hsa047300.17408612
83Lysine degradation_Homo sapiens_hsa003100.17183697
84Linoleic acid metabolism_Homo sapiens_hsa005910.16855996
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16000941
86Choline metabolism in cancer_Homo sapiens_hsa052310.15724651
87Viral carcinogenesis_Homo sapiens_hsa052030.15602199
88Melanoma_Homo sapiens_hsa052180.15403765
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15389861
90Glycerolipid metabolism_Homo sapiens_hsa005610.15195579
91Prolactin signaling pathway_Homo sapiens_hsa049170.13869067
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.12045328
93Calcium signaling pathway_Homo sapiens_hsa040200.11954680
94Gap junction_Homo sapiens_hsa045400.11473713
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.11317431
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.10951470
97Type II diabetes mellitus_Homo sapiens_hsa049300.10829443
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.10565075
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10229838
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.09250680

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