C5ORF46

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)8.76749477
2desmosome organization (GO:0002934)7.70593763
3regulation of water loss via skin (GO:0033561)7.69798495
4keratinization (GO:0031424)6.98490204
5keratinocyte proliferation (GO:0043616)6.37983348
6skin morphogenesis (GO:0043589)5.18442508
7collagen fibril organization (GO:0030199)4.85709535
8peptidyl-proline hydroxylation (GO:0019511)4.82264178
9multicellular organismal water homeostasis (GO:0050891)4.58200623
10hemidesmosome assembly (GO:0031581)4.32450115
11endothelium development (GO:0003158)4.14028334
12gap junction assembly (GO:0016264)4.13659396
13regulation of transforming growth factor beta1 production (GO:0032908)4.13343634
14keratinocyte differentiation (GO:0030216)4.11841063
15protein hydroxylation (GO:0018126)4.04597157
16endodermal cell differentiation (GO:0035987)3.84001779
17keratinocyte development (GO:0003334)3.75364370
18water homeostasis (GO:0030104)3.75321017
19establishment of planar polarity (GO:0001736)3.75291233
20establishment of tissue polarity (GO:0007164)3.75291233
21peptide cross-linking (GO:0018149)3.75101466
22negative regulation of chondrocyte differentiation (GO:0032331)3.72779534
23substrate-dependent cell migration (GO:0006929)3.68896850
24negative regulation of cardiac muscle tissue development (GO:0055026)3.67780091
25chondrocyte development (GO:0002063)3.62924752
26regulation of glomerular filtration (GO:0003093)3.58830819
27cell adhesion mediated by integrin (GO:0033627)3.56492012
28positive regulation of p38MAPK cascade (GO:1900745)3.54777414
29negative regulation of cardiac muscle tissue growth (GO:0055022)3.52436742
30negative regulation of heart growth (GO:0061117)3.52436742
31extracellular fibril organization (GO:0043206)3.44852150
32hair cycle (GO:0042633)3.43126774
33molting cycle (GO:0042303)3.43126774
34regulation of tight junction assembly (GO:2000810)3.32441736
35bundle of His cell to Purkinje myocyte communication (GO:0086069)3.30450685
36response to redox state (GO:0051775)3.29055165
37regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.20650966
38epidermis development (GO:0008544)3.20020316
39purine ribonucleotide transport (GO:0015868)3.19723256
40cellular response to arsenic-containing substance (GO:0071243)3.19393241
41ribosomal large subunit biogenesis (GO:0042273)3.19089661
42epidermal cell differentiation (GO:0009913)3.16058416
43regulation of cardioblast differentiation (GO:0051890)3.15014616
44intestinal epithelial cell development (GO:0060576)3.12718678
45regulation of transforming growth factor beta2 production (GO:0032909)3.12384286
464-hydroxyproline metabolic process (GO:0019471)3.08808668
47adenine nucleotide transport (GO:0051503)3.05164350
48positive regulation of osteoblast proliferation (GO:0033690)3.04995161
49ribosomal small subunit biogenesis (GO:0042274)3.03644395
50membrane raft organization (GO:0031579)3.03051520
51sequestering of extracellular ligand from receptor (GO:0035581)3.02433810
52dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.98827785
53regulation of type B pancreatic cell apoptotic process (GO:2000674)2.98354437
54fibril organization (GO:0097435)2.95749065
55collagen metabolic process (GO:0032963)2.94569475
56type B pancreatic cell proliferation (GO:0044342)2.93826953
57ER overload response (GO:0006983)2.92971092
58collagen catabolic process (GO:0030574)2.89705326
59fibrinolysis (GO:0042730)2.83715845
60basement membrane organization (GO:0071711)2.82522610
61chronic inflammatory response (GO:0002544)2.81290075
62cell migration involved in heart development (GO:0060973)2.80296299
63wound healing, spreading of epidermal cells (GO:0035313)2.79629999
64positive regulation of transforming growth factor beta production (GO:0071636)2.77156110
65SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.76939127
66ribonucleoprotein complex disassembly (GO:0032988)2.76153137
67COPII vesicle coating (GO:0048208)2.73602863
68cotranslational protein targeting to membrane (GO:0006613)2.73480666
69virion attachment to host cell (GO:0019062)2.72675880
70adhesion of symbiont to host cell (GO:0044650)2.72675880
71protein targeting to ER (GO:0045047)2.72652844
72chondrocyte proliferation (GO:0035988)2.72617215
73multicellular organismal macromolecule metabolic process (GO:0044259)2.68776934
74extracellular regulation of signal transduction (GO:1900115)2.68553932
75extracellular negative regulation of signal transduction (GO:1900116)2.68553932
76natural killer cell mediated cytotoxicity (GO:0042267)2.67572740
77natural killer cell mediated immunity (GO:0002228)2.67572740
78regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.67025577
79kidney mesenchyme development (GO:0072074)2.66680084
80establishment of protein localization to endoplasmic reticulum (GO:0072599)2.66546998
81membrane budding (GO:0006900)2.66151362
82muscle cell migration (GO:0014812)2.65061600
83negative regulation of stem cell proliferation (GO:2000647)2.63900218
84protein localization to endoplasmic reticulum (GO:0070972)2.63265342
85multicellular organismal catabolic process (GO:0044243)2.61495902
86negative regulation of muscle organ development (GO:0048635)2.61266447
87protein heterotrimerization (GO:0070208)2.60704195
88intermediate filament organization (GO:0045109)2.60389773
89regulation of collagen metabolic process (GO:0010712)2.60156225
90viral transcription (GO:0019083)2.58497440
91neural crest cell development (GO:0014032)2.56380245
92negative regulation of cartilage development (GO:0061037)2.55836544
93nucleotide-sugar biosynthetic process (GO:0009226)2.54633804
94extracellular matrix disassembly (GO:0022617)2.52183120
95long-chain fatty acid biosynthetic process (GO:0042759)2.52165709
96multicellular organismal metabolic process (GO:0044236)2.51860976
97regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.49220340
98protein retention in ER lumen (GO:0006621)2.48059866
99cellular response to zinc ion (GO:0071294)2.47754338
100regulation of metalloenzyme activity (GO:0048552)2.46738121

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.17712052
2TRIM28_21343339_ChIP-Seq_HEK293_Human6.07558441
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.50803705
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.19266516
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human4.01844823
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.51570782
7HIF1A_21447827_ChIP-Seq_MCF-7_Human3.11796962
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.83949334
9CJUN_26792858_Chip-Seq_BT549_Human2.83639534
10SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.65140585
11SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.65140585
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.43606819
13BRD4_25478319_ChIP-Seq_HGPS_Human2.37988279
14* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.30832233
15P63_26484246_Chip-Seq_KERATINOCYTES_Human2.30691271
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.24272859
17TP53_18474530_ChIP-ChIP_U2OS_Human2.17239143
18ELK1_19687146_ChIP-ChIP_HELA_Human2.11312188
19ELK1_22589737_ChIP-Seq_MCF10A_Human2.07845592
20NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.01672005
21NRF2_20460467_ChIP-Seq_MEFs_Mouse2.01672005
22CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.83905347
23* TP63_23658742_ChIP-Seq_EP156T_Human1.73381019
24JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69541823
25SOX9_24532713_ChIP-Seq_HFSC_Mouse1.67752948
26JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.62813066
27KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.61217074
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59444542
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56901154
30CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.54163489
31TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53681029
32FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.52679147
33UBF1/2_26484160_Chip-Seq_HMECs_Human1.50044144
34RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46598341
35EP300_21415370_ChIP-Seq_HL-1_Mouse1.45975167
36* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.43705305
37ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38498949
38SOX2_20726797_ChIP-Seq_SW620_Human1.36642066
39CLOCK_20551151_ChIP-Seq_293T_Human1.35719582
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.34677277
41TP53_16413492_ChIP-PET_HCT116_Human1.27526247
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.25662352
43ATF3_27146783_Chip-Seq_COLON_Human1.21026318
44ELF5_23300383_ChIP-Seq_T47D_Human1.18251808
45SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17414220
46MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.16714369
47KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15057912
48ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12112043
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.11322981
50GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.10461066
51KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.09963464
52DCP1A_22483619_ChIP-Seq_HELA_Human1.08434535
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07955245
54HNFA_21074721_ChIP-Seq_CACO-2_Human1.06800757
55SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05214337
56GATA6_21074721_ChIP-Seq_CACO-2_Human1.04260073
57CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.03429884
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.01128552
59TCF4_18268006_ChIP-ChIP_LS174T_Human1.00361081
60PIAS1_25552417_ChIP-Seq_VCAP_Human0.99426415
61FOXO3_23340844_ChIP-Seq_DLD1_Human0.97797917
62FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97663341
63RBPJ_21746931_ChIP-Seq_IB4_Human0.97372881
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97012346
65HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96962174
66GATA3_24758297_ChIP-Seq_MCF-7_Human0.95873033
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92156361
68NFI_21473784_ChIP-Seq_ESCs_Mouse0.89780577
69EST1_17652178_ChIP-ChIP_JURKAT_Human0.89661647
70ETS1_20019798_ChIP-Seq_JURKAT_Human0.88259208
71SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88240228
72PHF8_20622853_ChIP-Seq_HELA_Human0.87443278
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87149517
74SOX17_20123909_ChIP-Seq_XEN_Mouse0.87003948
75SMC1_22415368_ChIP-Seq_MEFs_Mouse0.86224696
76ESR2_21235772_ChIP-Seq_MCF-7_Human0.85907053
77TP53_22127205_ChIP-Seq_IMR90_Human0.85542657
78SA1_22415368_ChIP-Seq_MEFs_Mouse0.84818547
79PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83645058
80EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83495840
81P300_27058665_Chip-Seq_ZR-75-30cells_Human0.82971224
82JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.82601493
83CDX2_22108803_ChIP-Seq_LS180_Human0.82500494
84PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.81093925
85ESR1_20079471_ChIP-ChIP_T-47D_Human0.80832525
86CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.79321580
87UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.79303323
88HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78282265
89CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.77927070
90CSB_26484114_Chip-Seq_FIBROBLAST_Human0.77145540
91NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.74440740
92FUS_26573619_Chip-Seq_HEK293_Human0.74222931
93EZH2_27294783_Chip-Seq_NPCs_Mouse0.74097045
94NFYB_21822215_ChIP-Seq_K562_Human0.73383775
95TFEB_21752829_ChIP-Seq_HELA_Human0.72612313
96CREB1_15753290_ChIP-ChIP_HEK293T_Human0.71617106
97GATA4_25053715_ChIP-Seq_YYC3_Human0.71080921
98PCGF2_27294783_Chip-Seq_ESCs_Mouse0.69979773
99ETV1_20927104_ChIP-Seq_GIST48_Human0.69718165
100CDX2_19796622_ChIP-Seq_MESCs_Mouse0.69383683

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005275_abnormal_skin_tensile6.79925184
2MP0008438_abnormal_cutaneous_collagen6.04679641
3MP0002796_impaired_skin_barrier4.70316546
4MP0009379_abnormal_foot_pigmentation3.75570286
5MP0005503_abnormal_tendon_morphology3.59030354
6MP0003950_abnormal_plasma_membrane3.24846344
7MP0003279_aneurysm3.17348122
8MP0004272_abnormal_basement_membrane3.16485303
9MP0005501_abnormal_skin_physiology3.05947443
10MP0002060_abnormal_skin_morphology2.82641174
11MP0003705_abnormal_hypodermis_morpholog2.79147084
12MP0005257_abnormal_intraocular_pressure2.46881384
13MP0010234_abnormal_vibrissa_follicle2.46050606
14MP0001542_abnormal_bone_strength2.30147698
15MP0003941_abnormal_skin_development2.28349185
16MP0000762_abnormal_tongue_morphology2.18524802
17MP0003566_abnormal_cell_adhesion2.18322520
18MP0009384_cardiac_valve_regurgitation2.12029019
19MP0010030_abnormal_orbit_morphology2.06358448
20MP0010771_integument_phenotype2.01945902
21MP0001216_abnormal_epidermal_layer1.95197272
22MP0010368_abnormal_lymphatic_system1.93702779
23MP0005023_abnormal_wound_healing1.92416797
24MP0003453_abnormal_keratinocyte_physiol1.78889510
25MP0005508_abnormal_skeleton_morphology1.74870359
26MP0005623_abnormal_meninges_morphology1.64120957
27MP0000579_abnormal_nail_morphology1.50195182
28MP0005171_absent_coat_pigmentation1.46403707
29MP0005197_abnormal_uvea_morphology1.36255740
30MP0001958_emphysema1.35131750
31MP0002877_abnormal_melanocyte_morpholog1.34450154
32MP0006054_spinal_hemorrhage1.29535808
33MP0010386_abnormal_urinary_bladder1.29131990
34MP0001243_abnormal_dermal_layer1.28874890
35MP0003191_abnormal_cellular_cholesterol1.27246497
36MP0000750_abnormal_muscle_regeneration1.25508096
37MP0010678_abnormal_skin_adnexa1.23801543
38MP0009250_abnormal_appendicular_skeleto1.21176576
39MP0004947_skin_inflammation1.20357110
40MP0009053_abnormal_anal_canal1.17511982
41MP0002896_abnormal_bone_mineralization1.15140112
42MP0002282_abnormal_trachea_morphology1.12394696
43MP0005408_hypopigmentation1.11994362
44MP0002295_abnormal_pulmonary_circulatio1.08273605
45MP0001191_abnormal_skin_condition1.07916874
46MP0000015_abnormal_ear_pigmentation1.07062883
47MP0002177_abnormal_outer_ear1.06356171
48MP0003091_abnormal_cell_migration1.04063900
49MP0002095_abnormal_skin_pigmentation1.02853710
50MP0001879_abnormal_lymphatic_vessel1.00653725
51MP0002098_abnormal_vibrissa_morphology1.00456894
52MP0005193_abnormal_anterior_eye1.00379583
53MP0009780_abnormal_chondrocyte_physiolo0.99753812
54MP0000647_abnormal_sebaceous_gland0.96886484
55MP0000013_abnormal_adipose_tissue0.96287063
56MP0003755_abnormal_palate_morphology0.94210894
57MP0001853_heart_inflammation0.94067790
58MP0002108_abnormal_muscle_morphology0.93175125
59MP0001299_abnormal_eye_distance/0.92476430
60MP0009697_abnormal_copulation0.90796707
61MP0005174_abnormal_tail_pigmentation0.89527810
62MP0005164_abnormal_response_to0.89224815
63MP0000858_altered_metastatic_potential0.89015521
64MP0009931_abnormal_skin_appearance0.86693980
65MP0000377_abnormal_hair_follicle0.85856642
66MP0000427_abnormal_hair_cycle0.85681779
67MP0005390_skeleton_phenotype0.85185960
68MP0000163_abnormal_cartilage_morphology0.83101243
69MP0000462_abnormal_digestive_system0.81371921
70MP0000749_muscle_degeneration0.80494894
71MP0000767_abnormal_smooth_muscle0.78988479
72MP0002332_abnormal_exercise_endurance0.78580070
73MP0001340_abnormal_eyelid_morphology0.76569092
74MP0003385_abnormal_body_wall0.71619799
75MP0001915_intracranial_hemorrhage0.71567999
76MP0001188_hyperpigmentation0.71172195
77MP0000383_abnormal_hair_follicle0.70932993
78MP0002115_abnormal_skeleton_extremities0.69454375
79MP0004510_myositis0.69365512
80MP0000432_abnormal_head_morphology0.67103937
81MP0000428_abnormal_craniofacial_morphol0.66969160
82MP0000733_abnormal_muscle_development0.66735208
83MP0000467_abnormal_esophagus_morphology0.65970122
84MP0005165_increased_susceptibility_to0.65528738
85MP0002113_abnormal_skeleton_development0.64962844
86MP0002998_abnormal_bone_remodeling0.64141402
87MP0003828_pulmonary_edema0.64090757
88MP0000367_abnormal_coat/_hair0.62726548
89MP0000049_abnormal_middle_ear0.61858395
90MP0000627_abnormal_mammary_gland0.61417285
91MP0002006_tumorigenesis0.60996150
92MP0006082_CNS_inflammation0.60285744
93MP0003935_abnormal_craniofacial_develop0.59840465
94MP0000566_synostosis0.57587023
95MP0001851_eye_inflammation0.57399120
96MP0003448_altered_tumor_morphology0.56223336
97MP0001784_abnormal_fluid_regulation0.56177508
98MP0004134_abnormal_chest_morphology0.55365484
99MP0002109_abnormal_limb_morphology0.55340805
100MP0003186_abnormal_redox_activity0.55273875

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.60348934
2Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.69927326
3Atrophic scars (HP:0001075)4.46989319
4Protrusio acetabuli (HP:0003179)4.40742193
5Congenital ichthyosiform erythroderma (HP:0007431)4.29220779
6Aortic dissection (HP:0002647)4.25625080
7Fragile nails (HP:0001808)4.13658524
8Onycholysis (HP:0001806)4.01490110
9Erythroderma (HP:0001019)3.91582576
10Hypotrichosis (HP:0001006)3.90369821
11Fragile skin (HP:0001030)3.70970052
12Palmoplantar hyperkeratosis (HP:0000972)3.70515611
13Soft skin (HP:0000977)3.57280180
14Alopecia of scalp (HP:0002293)3.56400613
15Palmar hyperkeratosis (HP:0010765)3.51130094
16Spondylolisthesis (HP:0003302)3.48820404
17Arterial tortuosity (HP:0005116)3.42610844
18Plantar hyperkeratosis (HP:0007556)3.30605314
19Follicular hyperkeratosis (HP:0007502)3.30409472
20Selective tooth agenesis (HP:0001592)3.27732514
21Dry hair (HP:0011359)3.21861294
22Tetraparesis (HP:0002273)3.21723879
23Erythema (HP:0010783)3.16771806
24Short middle phalanx of the 5th finger (HP:0004220)3.16161093
25Osteolytic defects of the hand bones (HP:0009699)3.10947819
26Osteolytic defects of the phalanges of the hand (HP:0009771)3.10947819
27Vascular tortuosity (HP:0004948)3.07107840
28Aplasia involving bones of the extremities (HP:0009825)3.06957999
29Aplasia involving bones of the upper limbs (HP:0009823)3.06957999
30Aplasia of the phalanges of the hand (HP:0009802)3.06957999
31Metaphyseal dysplasia (HP:0100255)3.06454870
32Absent frontal sinuses (HP:0002688)3.05216378
33Bladder diverticulum (HP:0000015)3.02745904
34Abnormality of the axillary hair (HP:0100134)2.90964196
35Abnormality of secondary sexual hair (HP:0009888)2.90964196
36Wormian bones (HP:0002645)2.89614462
37Conjunctival hamartoma (HP:0100780)2.85878352
38Corneal erosion (HP:0200020)2.76822202
39Lip pit (HP:0100267)2.75371657
40Woolly hair (HP:0002224)2.73472250
41Right ventricular cardiomyopathy (HP:0011663)2.72609310
42Neonatal short-limb short stature (HP:0008921)2.63659390
43Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.63124343
44Abnormality of the frontal sinuses (HP:0002687)2.62762322
45Increased IgE level (HP:0003212)2.56801691
46Abnormality of nail color (HP:0100643)2.54395593
47Short nail (HP:0001799)2.46112423
48Vertebral compression fractures (HP:0002953)2.43053247
49Sparse eyelashes (HP:0000653)2.41648828
50Ulnar bowing (HP:0003031)2.41431768
51Aortic aneurysm (HP:0004942)2.40487730
52Sensory axonal neuropathy (HP:0003390)2.36672462
53Palmoplantar keratoderma (HP:0000982)2.30316515
54Blue sclerae (HP:0000592)2.29076923
55Abnormality of dentin (HP:0010299)2.28973832
56Oral leukoplakia (HP:0002745)2.27491293
57Sparse scalp hair (HP:0002209)2.23816439
58Thick nail (HP:0001805)2.23023692
59Cupped ribs (HP:0000887)2.20155090
60Mitral stenosis (HP:0001718)2.18626637
61Nasolacrimal duct obstruction (HP:0000579)2.17122920
62Hyperextensible skin (HP:0000974)2.14057557
63Parakeratosis (HP:0001036)2.13418281
64Dilatation of the ascending aorta (HP:0005111)2.10630903
65Nail dystrophy (HP:0008404)2.10155546
66Shallow orbits (HP:0000586)2.10044864
67Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.08079065
68Long nose (HP:0003189)2.07364361
69Radial bowing (HP:0002986)2.06233592
70Peritonitis (HP:0002586)2.06067804
71Genu recurvatum (HP:0002816)2.04384124
72Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.03147347
73Entropion (HP:0000621)2.02272341
74Tibial bowing (HP:0002982)1.99124936
75Mixed hearing impairment (HP:0000410)1.97143713
76Natal tooth (HP:0000695)1.94465381
77Knee flexion contracture (HP:0006380)1.92394792
78Ankle contracture (HP:0006466)1.92226741
79Reduced subcutaneous adipose tissue (HP:0003758)1.92018284
80Abnormality of molar (HP:0011077)1.91957025
81Abnormality of molar morphology (HP:0011070)1.91957025
82Coxa vara (HP:0002812)1.91533567
83Hyporeflexia of lower limbs (HP:0002600)1.91152307
84Cervical subluxation (HP:0003308)1.89994456
85Hypoplastic left heart (HP:0004383)1.87556026
86Mitral valve prolapse (HP:0001634)1.86758006
87Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.84331985
88Bifid uvula (HP:0000193)1.83237761
89Patent foramen ovale (HP:0001655)1.82678552
90Abnormal delivery (HP:0001787)1.82607270
91Amniotic constriction ring (HP:0009775)1.82547901
92Abnormality of placental membranes (HP:0011409)1.82547901
93Bowed forearm bones (HP:0003956)1.82170400
94Bowing of the arm (HP:0006488)1.82170400
95Xerostomia (HP:0000217)1.80834442
96Thin skin (HP:0000963)1.77007463
97Cardiovascular calcification (HP:0011915)1.74572242
98Hamartoma of the eye (HP:0010568)1.73047461
99Abnormality of permanent molar morphology (HP:0011071)1.71158106
100Taurodontia (HP:0000679)1.71158106

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.62546085
2STK244.19192242
3MYLK3.53116297
4TESK12.98997892
5EIF2AK32.97838288
6MAP3K122.61726624
7PAK42.37912200
8MST1R2.35542363
9LIMK12.31872330
10STK162.29790841
11LATS22.24212397
12NME22.23062101
13IRAK32.19706183
14MAP3K32.06804402
15EPHB22.05049441
16ILK1.95534165
17EIF2AK11.91754985
18MAP3K61.89134572
19PIK3CG1.83701961
20ARAF1.81236739
21MST41.79401372
22TGFBR21.78214379
23PAK21.77743545
24PTK21.75536091
25CDK81.60443286
26MOS1.56471490
27MET1.55095922
28STK38L1.51435499
29MAPK71.48527879
30PBK1.47619405
31TGFBR11.45532917
32LMTK21.44143193
33PIM21.34883925
34TTN1.33480550
35SRPK11.32522605
36MAP3K21.24890410
37ERBB41.19747074
38STK31.18304843
39BCR1.16496204
40RIPK11.16346099
41PRKCE1.10303001
42TRPM71.09789505
43NEK91.05775226
44NME11.05232652
45BRSK21.03623705
46STK380.97880149
47ABL20.96590815
48DDR20.94060544
49PRKG20.93586657
50FGFR10.91130434
51RPS6KB20.89611523
52DMPK0.85736267
53MAPK120.84589500
54MAPKAPK30.79803703
55PHKG20.79003900
56PHKG10.79003900
57KIT0.77827705
58DAPK30.74532638
59NTRK10.69530725
60PDGFRA0.65786003
61ERBB30.64268832
62BUB10.64009894
63VRK10.63438017
64TIE10.62720414
65ROCK10.62366261
66ADRBK10.60910876
67ROCK20.55544742
68EIF2AK20.55414668
69GSK3A0.54977608
70LATS10.52936137
71CDK90.52740086
72CAMK2G0.50307485
73PLK20.50216287
74RPS6KA40.49667908
75BMPR1B0.46765706
76ICK0.46518969
77INSRR0.41017119
78PTK2B0.40945379
79TBK10.39442427
80SIK10.39398742
81MAPKAPK20.39201277
82MAP3K50.37670013
83STK100.34495512
84TAOK20.34035068
85MAPKAPK50.32654806
86PRPF4B0.32118300
87PKN10.31838513
88FLT30.29812724
89PIK3CA0.29526851
90MAP3K90.28301278
91DYRK30.27495592
92CASK0.27447439
93PDGFRB0.27213715
94PAK10.26593966
95AURKB0.25949902
96ERN10.25772904
97MTOR0.24853488
98PAK60.24645001
99PRKCI0.24279173
100MAP2K10.22005707

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.94444336
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.83873714
3ECM-receptor interaction_Homo sapiens_hsa045123.69906517
4Protein export_Homo sapiens_hsa030603.51771925
5Circadian rhythm_Homo sapiens_hsa047102.82942155
6Oxidative phosphorylation_Homo sapiens_hsa001902.21531514
7Amoebiasis_Homo sapiens_hsa051462.18180225
8Focal adhesion_Homo sapiens_hsa045102.07262289
9Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.05910945
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.00803761
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.97033823
12Nucleotide excision repair_Homo sapiens_hsa034201.94747607
13Malaria_Homo sapiens_hsa051441.88821556
14p53 signaling pathway_Homo sapiens_hsa041151.83573368
15Basal transcription factors_Homo sapiens_hsa030221.81788196
16Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.75988697
17Proteasome_Homo sapiens_hsa030501.70952698
18Protein digestion and absorption_Homo sapiens_hsa049741.67822606
19Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.66463997
20Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.61100373
21Sphingolipid metabolism_Homo sapiens_hsa006001.59817182
22Vibrio cholerae infection_Homo sapiens_hsa051101.48769443
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.46234314
24Alzheimers disease_Homo sapiens_hsa050101.44218191
25Proteoglycans in cancer_Homo sapiens_hsa052051.42389383
26Small cell lung cancer_Homo sapiens_hsa052221.40050269
27RNA polymerase_Homo sapiens_hsa030201.36764921
28TGF-beta signaling pathway_Homo sapiens_hsa043501.33932629
29Parkinsons disease_Homo sapiens_hsa050121.31711036
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.20484477
31Sulfur metabolism_Homo sapiens_hsa009201.18775534
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16707567
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.13979597
34AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13168725
35Hippo signaling pathway_Homo sapiens_hsa043901.10831811
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10720462
37Huntingtons disease_Homo sapiens_hsa050161.09036089
38N-Glycan biosynthesis_Homo sapiens_hsa005101.08771788
39Adherens junction_Homo sapiens_hsa045201.08419686
40Pertussis_Homo sapiens_hsa051331.06663809
41Glutathione metabolism_Homo sapiens_hsa004801.05295607
42Basal cell carcinoma_Homo sapiens_hsa052171.03417716
43Legionellosis_Homo sapiens_hsa051341.02444293
44African trypanosomiasis_Homo sapiens_hsa051431.01542639
45PI3K-Akt signaling pathway_Homo sapiens_hsa041510.99583255
46Folate biosynthesis_Homo sapiens_hsa007900.96377115
47Salmonella infection_Homo sapiens_hsa051320.92558030
48Collecting duct acid secretion_Homo sapiens_hsa049660.90250003
49Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88156653
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84607566
51Rheumatoid arthritis_Homo sapiens_hsa053230.83297116
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82871951
53Histidine metabolism_Homo sapiens_hsa003400.80447711
54Renal cell carcinoma_Homo sapiens_hsa052110.79572524
55Fatty acid elongation_Homo sapiens_hsa000620.79112510
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77944122
57Dilated cardiomyopathy_Homo sapiens_hsa054140.77729168
58Pathways in cancer_Homo sapiens_hsa052000.72607197
59Pyrimidine metabolism_Homo sapiens_hsa002400.68993562
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66260660
61Galactose metabolism_Homo sapiens_hsa000520.65001879
62Hedgehog signaling pathway_Homo sapiens_hsa043400.64575752
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64540540
64Dorso-ventral axis formation_Homo sapiens_hsa043200.64304030
65Arachidonic acid metabolism_Homo sapiens_hsa005900.63956238
66Wnt signaling pathway_Homo sapiens_hsa043100.61591323
67Bladder cancer_Homo sapiens_hsa052190.58731591
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58519219
69TNF signaling pathway_Homo sapiens_hsa046680.58440133
70Melanogenesis_Homo sapiens_hsa049160.57316430
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57169708
72Regulation of autophagy_Homo sapiens_hsa041400.56241703
73Cardiac muscle contraction_Homo sapiens_hsa042600.56072307
74Endocytosis_Homo sapiens_hsa041440.56004529
75HIF-1 signaling pathway_Homo sapiens_hsa040660.54087009
76Mineral absorption_Homo sapiens_hsa049780.52463830
77Shigellosis_Homo sapiens_hsa051310.51968111
78Fructose and mannose metabolism_Homo sapiens_hsa000510.50333097
79Tight junction_Homo sapiens_hsa045300.48067727
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45905070
81Pancreatic cancer_Homo sapiens_hsa052120.44230410
82RNA transport_Homo sapiens_hsa030130.41819720
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41187910
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41025272
85Thyroid cancer_Homo sapiens_hsa052160.39725213
86Melanoma_Homo sapiens_hsa052180.38291070
87Vitamin digestion and absorption_Homo sapiens_hsa049770.37313868
88Ras signaling pathway_Homo sapiens_hsa040140.37308387
89Arginine and proline metabolism_Homo sapiens_hsa003300.37256127
90Chemical carcinogenesis_Homo sapiens_hsa052040.34816849
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33080308
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.32780601
93Metabolic pathways_Homo sapiens_hsa011000.31878556
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30545353
95Lysosome_Homo sapiens_hsa041420.29109682
96Alcoholism_Homo sapiens_hsa050340.29105982
97Retinol metabolism_Homo sapiens_hsa008300.28109400
98Starch and sucrose metabolism_Homo sapiens_hsa005000.25846623
99Sulfur relay system_Homo sapiens_hsa041220.25393233
100Axon guidance_Homo sapiens_hsa043600.25139142

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