C4ORF50

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)7.19040141
2synaptic vesicle docking involved in exocytosis (GO:0016081)7.10522535
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)6.46303106
4glutamate secretion (GO:0014047)6.14344474
5regulation of short-term neuronal synaptic plasticity (GO:0048172)6.07546525
6membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.99802025
7L-amino acid import (GO:0043092)5.89581387
8synaptic vesicle exocytosis (GO:0016079)5.78952808
9regulation of synaptic vesicle exocytosis (GO:2000300)5.46823086
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.26520450
11ionotropic glutamate receptor signaling pathway (GO:0035235)5.09567730
12regulation of synaptic vesicle transport (GO:1902803)4.81066314
13amino acid import (GO:0043090)4.63753426
14synaptic transmission, glutamatergic (GO:0035249)4.62519746
15exploration behavior (GO:0035640)4.47389565
16neurotransmitter secretion (GO:0007269)4.46590864
17locomotory exploration behavior (GO:0035641)4.45407694
18phosphorelay signal transduction system (GO:0000160)4.44570647
19sodium ion export (GO:0071436)4.42544735
20regulation of neuronal synaptic plasticity (GO:0048168)4.41636053
21neuron-neuron synaptic transmission (GO:0007270)4.41509127
22cellular potassium ion homeostasis (GO:0030007)4.39528555
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.33469720
24gamma-aminobutyric acid signaling pathway (GO:0007214)4.26918762
25protein localization to synapse (GO:0035418)4.20064430
26negative regulation of synaptic transmission, GABAergic (GO:0032229)4.16699456
27startle response (GO:0001964)4.11949383
28retinal cone cell development (GO:0046549)4.06946387
29glutamate receptor signaling pathway (GO:0007215)4.04661522
30regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.98249537
31serotonin metabolic process (GO:0042428)3.95160803
32neurotransmitter-gated ion channel clustering (GO:0072578)3.94997074
33sleep (GO:0030431)3.94256011
34regulation of excitatory postsynaptic membrane potential (GO:0060079)3.91979926
35membrane depolarization during action potential (GO:0086010)3.91238310
36vocalization behavior (GO:0071625)3.89353061
37negative regulation of dendrite morphogenesis (GO:0050774)3.87416391
38positive regulation of membrane potential (GO:0045838)3.87323721
39regulation of long-term neuronal synaptic plasticity (GO:0048169)3.85750734
40neurotransmitter transport (GO:0006836)3.85488033
41regulation of neurotransmitter secretion (GO:0046928)3.84901020
42neuronal action potential propagation (GO:0019227)3.76614419
43gamma-aminobutyric acid transport (GO:0015812)3.74248746
44regulation of glutamate receptor signaling pathway (GO:1900449)3.73444163
45regulation of synaptic plasticity (GO:0048167)3.70294674
46regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.68993609
47transmission of nerve impulse (GO:0019226)3.66058213
48cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.64486176
49positive regulation of neurotransmitter secretion (GO:0001956)3.64348676
50regulation of postsynaptic membrane potential (GO:0060078)3.62273115
51regulation of synapse structural plasticity (GO:0051823)3.58587691
52synaptic vesicle endocytosis (GO:0048488)3.55581646
53regulation of voltage-gated calcium channel activity (GO:1901385)3.54671407
54cerebellar Purkinje cell differentiation (GO:0021702)3.53075182
55regulation of calcium ion-dependent exocytosis (GO:0017158)3.52385762
56behavioral fear response (GO:0001662)3.51993057
57behavioral defense response (GO:0002209)3.51993057
58regulation of neurotransmitter transport (GO:0051588)3.51955760
59positive regulation of synapse maturation (GO:0090129)3.45350486
60membrane depolarization (GO:0051899)3.45062807
61regulation of dendritic spine morphogenesis (GO:0061001)3.44900897
62behavioral response to cocaine (GO:0048148)3.44415427
63primary amino compound metabolic process (GO:1901160)3.43971020
64long-term synaptic potentiation (GO:0060291)3.43828442
65neuron cell-cell adhesion (GO:0007158)3.42600692
66G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.41865921
67positive regulation of dendritic spine development (GO:0060999)3.38951929
68regulation of acrosome reaction (GO:0060046)3.38320246
69neuronal ion channel clustering (GO:0045161)3.37846772
70postsynaptic membrane organization (GO:0001941)3.36147548
71regulation of ARF protein signal transduction (GO:0032012)3.35047378
72presynaptic membrane assembly (GO:0097105)3.31707696
73positive regulation of dendritic spine morphogenesis (GO:0061003)3.31416464
74positive regulation of neurotransmitter transport (GO:0051590)3.30718101
75cerebellar granule cell differentiation (GO:0021707)3.29535452
76regulation of female receptivity (GO:0045924)3.27160883
77negative regulation of dendrite development (GO:2000171)3.26251455
78regulation of female gonad development (GO:2000194)3.25777002
79regulation of dendritic spine development (GO:0060998)3.24807158
80fear response (GO:0042596)3.23392284
81potassium ion import (GO:0010107)3.22698158
82regulation of neurotransmitter levels (GO:0001505)3.22150779
83neuromuscular process controlling posture (GO:0050884)3.20428717
84long-term memory (GO:0007616)3.19142721
85glycine transport (GO:0015816)3.17379091
86synaptic transmission (GO:0007268)3.16977622
87axon ensheathment in central nervous system (GO:0032291)3.13435026
88central nervous system myelination (GO:0022010)3.13435026
89dendritic spine morphogenesis (GO:0060997)3.13142901
90presynaptic membrane organization (GO:0097090)3.08205487
91cochlea development (GO:0090102)3.07674007
92proline transport (GO:0015824)3.06761412
93cellular sodium ion homeostasis (GO:0006883)3.06505971
94regulation of synaptic transmission, glutamatergic (GO:0051966)3.03453525
95regulation of synaptic transmission (GO:0050804)3.03318070
96neuromuscular process controlling balance (GO:0050885)3.02777297
97neuromuscular process (GO:0050905)2.99675995
98regulation of exocytosis (GO:0017157)2.98310543
99cell communication by electrical coupling (GO:0010644)2.97722967
100regulation of dopamine metabolic process (GO:0042053)2.96465690

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.90796503
2GBX2_23144817_ChIP-Seq_PC3_Human3.56670421
3DROSHA_22980978_ChIP-Seq_HELA_Human3.16081952
4REST_21632747_ChIP-Seq_MESCs_Mouse2.83941883
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.68807770
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.64016403
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.46722114
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.40480570
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.33621354
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.28832403
11SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.23949047
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.10510926
13REST_18959480_ChIP-ChIP_MESCs_Mouse2.08895600
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04921696
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.03048790
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.00220912
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.96844664
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.95477466
19EZH2_18974828_ChIP-Seq_MESCs_Mouse1.95244053
20RNF2_18974828_ChIP-Seq_MESCs_Mouse1.95244053
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.91842013
22GATA1_22025678_ChIP-Seq_K562_Human1.85830762
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81233244
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80992228
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.80900785
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.78473610
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.78075547
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77474707
29AR_21572438_ChIP-Seq_LNCaP_Human1.73590359
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.71291707
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68969422
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.68641066
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66493748
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61166207
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.55554899
36TAF15_26573619_Chip-Seq_HEK293_Human1.55008896
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.51394179
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.49712415
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46321495
40STAT3_23295773_ChIP-Seq_U87_Human1.41902192
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41056733
42* TCF4_23295773_ChIP-Seq_U87_Human1.37014741
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36064624
44RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35904678
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35887545
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35619383
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34464247
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33062755
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33062755
50PRDM14_20953172_ChIP-Seq_ESCs_Human1.32733186
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.32455883
52RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.32199003
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31239764
54AR_19668381_ChIP-Seq_PC3_Human1.28515507
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26124207
56P300_19829295_ChIP-Seq_ESCs_Human1.24732732
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24668685
58GATA1_26923725_Chip-Seq_HPCs_Mouse1.23305535
59AR_25329375_ChIP-Seq_VCAP_Human1.22157172
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21170051
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20436308
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17371783
63CTNNB1_20460455_ChIP-Seq_HCT116_Human1.16936056
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16699227
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.14842039
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14401652
67LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13329742
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12984224
69MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11569746
70SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09382684
71TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07098583
72RNF2_27304074_Chip-Seq_NSC_Mouse1.06222952
73AHR_22903824_ChIP-Seq_MCF-7_Human1.05118862
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.04750334
75SMAD4_21741376_ChIP-Seq_HESCs_Human1.03621377
76KDM2B_26808549_Chip-Seq_REH_Human1.03520532
77RUNX2_22187159_ChIP-Seq_PCA_Human1.03418151
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03236711
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02612940
80SMAD4_21741376_ChIP-Seq_EPCs_Human1.01004024
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00591597
82SMAD3_21741376_ChIP-Seq_ESCs_Human0.98997932
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98833146
84YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98460965
85ARNT_22903824_ChIP-Seq_MCF-7_Human0.98380243
86SMAD3_21741376_ChIP-Seq_HESCs_Human0.97072200
87TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94214528
88NANOG_18555785_Chip-Seq_ESCs_Mouse0.93075719
89IGF1R_20145208_ChIP-Seq_DFB_Human0.92690235
90RXR_22108803_ChIP-Seq_LS180_Human0.90928634
91CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89808622
92FLI1_21867929_ChIP-Seq_TH2_Mouse0.88888733
93CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88201867
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87782463
95EP300_21415370_ChIP-Seq_HL-1_Mouse0.87494216
96RING1B_27294783_Chip-Seq_ESCs_Mouse0.86102579
97BCAT_22108803_ChIP-Seq_LS180_Human0.84793770
98POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84750144
99BMI1_23680149_ChIP-Seq_NPCS_Mouse0.84255850
100RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.83993056

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.57866481
2MP0003880_abnormal_central_pattern4.77779002
3MP0004270_analgesia4.27094024
4MP0003635_abnormal_synaptic_transmissio4.17657064
5MP0002064_seizures3.60737542
6MP0009745_abnormal_behavioral_response3.57854652
7MP0002063_abnormal_learning/memory/cond3.27335467
8MP0002272_abnormal_nervous_system3.22939135
9MP0001486_abnormal_startle_reflex3.17157429
10MP0009046_muscle_twitch3.07416235
11MP0001968_abnormal_touch/_nociception2.95416765
12MP0005423_abnormal_somatic_nervous2.93487489
13MP0001501_abnormal_sleep_pattern2.89823374
14MP0003879_abnormal_hair_cell2.89708116
15MP0002734_abnormal_mechanical_nocicepti2.85553599
16MP0002735_abnormal_chemical_nociception2.85486576
17MP0002572_abnormal_emotion/affect_behav2.75392899
18MP0002736_abnormal_nociception_after2.16448285
19MP0002822_catalepsy2.08757409
20MP0008877_abnormal_DNA_methylation1.97621240
21MP0001970_abnormal_pain_threshold1.93507182
22MP0002067_abnormal_sensory_capabilities1.91258412
23MP0002733_abnormal_thermal_nociception1.85114671
24MP0005646_abnormal_pituitary_gland1.83068282
25MP0008569_lethality_at_weaning1.82001357
26MP0006276_abnormal_autonomic_nervous1.77789840
27MP0003633_abnormal_nervous_system1.71332271
28MP0001984_abnormal_olfaction1.70695194
29MP0003690_abnormal_glial_cell1.68430961
30MP0003329_amyloid_beta_deposits1.65188987
31MP0004924_abnormal_behavior1.59160398
32MP0005386_behavior/neurological_phenoty1.59160398
33MP0004811_abnormal_neuron_physiology1.55929484
34MP0000569_abnormal_digit_pigmentation1.52346495
35MP0002557_abnormal_social/conspecific_i1.51444152
36MP0001440_abnormal_grooming_behavior1.51119928
37MP0000778_abnormal_nervous_system1.47419820
38MP0002066_abnormal_motor_capabilities/c1.43653779
39MP0005551_abnormal_eye_electrophysiolog1.40989526
40MP0002882_abnormal_neuron_morphology1.40072632
41MP0003631_nervous_system_phenotype1.38150771
42MP0003183_abnormal_peptide_metabolism1.36148848
43MP0002638_abnormal_pupillary_reflex1.33970327
44MP0003787_abnormal_imprinting1.32349020
45MP0003718_maternal_effect1.29436153
46MP0002229_neurodegeneration1.28381636
47MP0009780_abnormal_chondrocyte_physiolo1.25751198
48MP0004885_abnormal_endolymph1.24795097
49MP0001485_abnormal_pinna_reflex1.23889861
50MP0000955_abnormal_spinal_cord1.23722511
51MP0001905_abnormal_dopamine_level1.22614134
52MP0001986_abnormal_taste_sensitivity1.20209482
53MP0000920_abnormal_myelination1.19420952
54MP0001963_abnormal_hearing_physiology1.16896563
55MP0003890_abnormal_embryonic-extraembry1.13735244
56MP0004742_abnormal_vestibular_system1.13392497
57MP0001177_atelectasis1.12214608
58MP0005645_abnormal_hypothalamus_physiol1.11236484
59MP0001502_abnormal_circadian_rhythm1.11145533
60MP0010386_abnormal_urinary_bladder1.09959432
61MP0002184_abnormal_innervation1.05143862
62MP0002152_abnormal_brain_morphology0.98557474
63MP0003045_fibrosis0.91627939
64MP0008874_decreased_physiological_sensi0.91481973
65MP0004147_increased_porphyrin_level0.88483880
66MP0004142_abnormal_muscle_tone0.81936723
67MP0000631_abnormal_neuroendocrine_gland0.80396229
68MP0000604_amyloidosis0.80072796
69MP0004510_myositis0.79594112
70MP0003632_abnormal_nervous_system0.79426755
71MP0008872_abnormal_physiological_respon0.78083816
72MP0002069_abnormal_eating/drinking_beha0.75251325
73MP0004085_abnormal_heartbeat0.72859088
74MP0002752_abnormal_somatic_nervous0.71373573
75MP0008057_abnormal_DNA_replication0.66546429
76MP0001664_abnormal_digestion0.65847920
77MP0003634_abnormal_glial_cell0.63502356
78MP0005394_taste/olfaction_phenotype0.62660390
79MP0005499_abnormal_olfactory_system0.62660390
80MP0003075_altered_response_to0.61880831
81MP0001529_abnormal_vocalization0.60798447
82MP0001348_abnormal_lacrimal_gland0.60096817
83MP0003122_maternal_imprinting0.58648130
84MP0003137_abnormal_impulse_conducting0.58110374
85MP0005535_abnormal_body_temperature0.57959012
86MP0005395_other_phenotype0.57937562
87MP0004130_abnormal_muscle_cell0.57224950
88MP0000427_abnormal_hair_cycle0.54950985
89MP0003121_genomic_imprinting0.54938758
90MP0004043_abnormal_pH_regulation0.52981943
91MP0002909_abnormal_adrenal_gland0.52779440
92MP0001929_abnormal_gametogenesis0.52734323
93MP0003698_abnormal_male_reproductive0.52591705
94MP0002161_abnormal_fertility/fecundity0.52065614
95MP0000026_abnormal_inner_ear0.50784303
96MP0010769_abnormal_survival0.48170438
97MP0001765_abnormal_ion_homeostasis0.47776127
98MP0006292_abnormal_olfactory_placode0.47335046
99MP0001943_abnormal_respiration0.46826832
100MP0002090_abnormal_vision0.46576170

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.55457782
2Focal motor seizures (HP:0011153)8.21651946
3Focal seizures (HP:0007359)6.44176087
4Febrile seizures (HP:0002373)5.53438634
5Action tremor (HP:0002345)5.45461261
6Epileptic encephalopathy (HP:0200134)5.14262909
7Atonic seizures (HP:0010819)4.79466110
8Progressive cerebellar ataxia (HP:0002073)4.50026155
9Generalized tonic-clonic seizures (HP:0002069)4.21029714
10Supranuclear gaze palsy (HP:0000605)3.92822764
11Hyperventilation (HP:0002883)3.91194832
12Dialeptic seizures (HP:0011146)3.89174017
13Diplopia (HP:0000651)3.84844606
14Abnormality of binocular vision (HP:0011514)3.84844606
15Absence seizures (HP:0002121)3.73350884
16Ankle clonus (HP:0011448)3.68408426
17Postural instability (HP:0002172)3.59618196
18Gaze-evoked nystagmus (HP:0000640)3.58519956
19Dysdiadochokinesis (HP:0002075)3.56301261
20Spastic gait (HP:0002064)3.55164063
21Poor eye contact (HP:0000817)3.49840704
22Truncal ataxia (HP:0002078)3.38467677
23Epileptiform EEG discharges (HP:0011182)3.37265659
24Urinary bladder sphincter dysfunction (HP:0002839)3.34301587
25Papilledema (HP:0001085)3.33840897
26Mutism (HP:0002300)3.22391145
27Torticollis (HP:0000473)3.14319256
28Abnormal eating behavior (HP:0100738)3.11197905
29Dysmetria (HP:0001310)3.09658151
30Impaired vibration sensation in the lower limbs (HP:0002166)3.05384921
31Neurofibrillary tangles (HP:0002185)3.03460339
32Broad-based gait (HP:0002136)3.01630346
33Dysmetric saccades (HP:0000641)2.96854488
34Status epilepticus (HP:0002133)2.95107175
35Abnormal social behavior (HP:0012433)2.89981531
36Impaired social interactions (HP:0000735)2.89981531
37EEG with generalized epileptiform discharges (HP:0011198)2.78035074
38Visual hallucinations (HP:0002367)2.74013388
39Hemiplegia (HP:0002301)2.71969662
40Intention tremor (HP:0002080)2.68218908
41Obstructive sleep apnea (HP:0002870)2.65067276
42Neuronal loss in central nervous system (HP:0002529)2.64362871
43Impaired smooth pursuit (HP:0007772)2.63034125
44Urinary urgency (HP:0000012)2.62441635
45Drooling (HP:0002307)2.61180785
46Hypsarrhythmia (HP:0002521)2.59667001
47Impaired vibratory sensation (HP:0002495)2.59556603
48Tetraplegia (HP:0002445)2.58792396
49Apathy (HP:0000741)2.52527943
50Amblyopia (HP:0000646)2.51638111
51Genetic anticipation (HP:0003743)2.50644015
52Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.49905290
53Excessive salivation (HP:0003781)2.49568186
54Cerebral inclusion bodies (HP:0100314)2.49058496
55Absent speech (HP:0001344)2.48597819
56Bradykinesia (HP:0002067)2.45142834
57Focal dystonia (HP:0004373)2.42807580
58Increased circulating renin level (HP:0000848)2.42796665
59Scanning speech (HP:0002168)2.40959098
60Depression (HP:0000716)2.38719787
61Agnosia (HP:0010524)2.38526271
62Clonus (HP:0002169)2.35800758
63Abnormality of ocular smooth pursuit (HP:0000617)2.35439968
64Akinesia (HP:0002304)2.35370704
65Limb dystonia (HP:0002451)2.34876557
66Inability to walk (HP:0002540)2.30285620
67Syncope (HP:0001279)2.28844433
68Delusions (HP:0000746)2.24630604
69Protruding tongue (HP:0010808)2.21691212
70Lower limb muscle weakness (HP:0007340)2.20645517
71Annular pancreas (HP:0001734)2.20538620
72Craniofacial dystonia (HP:0012179)2.20388174
73Generalized hypopigmentation of hair (HP:0011358)2.19638778
74Diminished motivation (HP:0000745)2.19488078
75Hemiparesis (HP:0001269)2.17147711
76Stereotypic behavior (HP:0000733)2.14412376
77Abnormality of the corticospinal tract (HP:0002492)2.12929413
78Abnormality of saccadic eye movements (HP:0000570)2.11380407
79Anxiety (HP:0000739)2.07288994
80Memory impairment (HP:0002354)2.06886432
81Prolonged QT interval (HP:0001657)2.06769665
82Fair hair (HP:0002286)2.05457612
83Fetal akinesia sequence (HP:0001989)2.01893574
84Bundle branch block (HP:0011710)1.98293292
85Incomplete penetrance (HP:0003829)1.90113835
86Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.89728058
87Degeneration of the lateral corticospinal tracts (HP:0002314)1.89728058
88Generalized aminoaciduria (HP:0002909)1.87463676
89Rigidity (HP:0002063)1.86631018
90Gait ataxia (HP:0002066)1.85195251
91Ventricular fibrillation (HP:0001663)1.82594526
92Inappropriate behavior (HP:0000719)1.82319657
93Cerebral hypomyelination (HP:0006808)1.82298320
94Papillary thyroid carcinoma (HP:0002895)1.82149449
95Clumsiness (HP:0002312)1.80689298
96Gonadotropin excess (HP:0000837)1.77813221
97Peripheral hypomyelination (HP:0007182)1.76464593
98Anterior segment dysgenesis (HP:0007700)1.76397207
99Intellectual disability, profound (HP:0002187)1.75390330
100Slow saccadic eye movements (HP:0000514)1.75063352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.21931406
2NTRK34.36976921
3MARK13.48369361
4MAP3K93.31816375
5DAPK23.05218712
6NTRK23.00152652
7RIPK42.56165998
8PAK62.46226667
9CASK2.41601195
10CAMKK12.01780603
11PRKD32.00642596
12ARAF1.91600241
13FRK1.79537386
14LATS21.75314111
15MAP3K131.73999804
16MAPK131.68154380
17CDK191.67130588
18MINK11.64254951
19DAPK11.58615730
20CDK51.57264437
21UHMK11.51706550
22NTRK11.49591018
23CAMK11.46617896
24NEK61.42210258
25GRK51.38226130
26KSR21.31263740
27PLK21.30107557
28MAP3K41.28622198
29PRKCG1.27201411
30CAMK2B1.27034450
31BMPR21.24852594
32CCNB11.22335589
33CAMK2A1.14354928
34TYRO31.10635897
35CAMKK21.06973890
36TAOK31.02647979
37BRAF1.01773012
38PINK10.99535725
39CAMK1G0.98893383
40MARK20.97531168
41TNK20.96130650
42SIK20.94175084
43SGK4940.94140492
44SGK2230.94140492
45SGK20.92090328
46SGK10.88069382
47PRKCH0.85093197
48STK110.83466250
49RAF10.82965046
50PDK10.81063815
51CAMK1D0.80085889
52OXSR10.79258533
53MAPK100.78447056
54STK380.77693996
55MAPK120.77082485
56CAMK40.76274074
57CDK120.75673458
58PAK30.75046926
59CDK150.73975542
60PNCK0.71539603
61CDK180.70311550
62FES0.69650527
63PRKCZ0.68462277
64DYRK1A0.67640039
65CDK11A0.67504341
66RPS6KA30.64521297
67CSNK1G20.61354065
68FGFR20.61264952
69AKT30.61021597
70TNIK0.58986885
71SGK30.57922877
72CDK140.57639155
73PTK2B0.56552452
74KSR10.56293838
75WNK10.56286614
76PRPF4B0.54862258
77CSNK1D0.53231368
78FYN0.51801344
79MAP2K70.48494033
80MOS0.48475920
81AURKA0.46743329
82PDPK10.46610005
83PRKG10.44565257
84PKN10.44359953
85MAP2K40.43924922
86MAPK70.42330292
87PRKCB0.40686043
88GSK3B0.38551117
89PRKCA0.37795924
90JAK10.36263720
91CAMK2G0.35738607
92PRKACA0.35493400
93ALK0.34879460
94SYK0.33984445
95RET0.33889737
96PRKACB0.33755772
97BRSK10.33399041
98ADRBK20.33197000
99TXK0.32566185
100CSNK1E0.31352384

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.72845714
2Synaptic vesicle cycle_Homo sapiens_hsa047213.12989494
3Long-term potentiation_Homo sapiens_hsa047202.98759374
4Morphine addiction_Homo sapiens_hsa050322.92473627
5Amphetamine addiction_Homo sapiens_hsa050312.90472684
6Circadian entrainment_Homo sapiens_hsa047132.89252426
7GABAergic synapse_Homo sapiens_hsa047272.83128767
8Glutamatergic synapse_Homo sapiens_hsa047242.69763278
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.63200936
10Insulin secretion_Homo sapiens_hsa049112.39559383
11Cocaine addiction_Homo sapiens_hsa050302.20948131
12Dopaminergic synapse_Homo sapiens_hsa047282.15350201
13Gastric acid secretion_Homo sapiens_hsa049712.05373154
14Aldosterone synthesis and secretion_Homo sapiens_hsa049252.04472800
15Cholinergic synapse_Homo sapiens_hsa047252.02803638
16Salivary secretion_Homo sapiens_hsa049701.95688236
17Taste transduction_Homo sapiens_hsa047421.86573693
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.81096652
19Calcium signaling pathway_Homo sapiens_hsa040201.77739233
20Oxytocin signaling pathway_Homo sapiens_hsa049211.71964248
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66715871
22cAMP signaling pathway_Homo sapiens_hsa040241.61802211
23Olfactory transduction_Homo sapiens_hsa047401.59084065
24Renin secretion_Homo sapiens_hsa049241.53773294
25Phosphatidylinositol signaling system_Homo sapiens_hsa040701.52522688
26Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.50300435
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43699150
28Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.40760862
29Serotonergic synapse_Homo sapiens_hsa047261.40723405
30Gap junction_Homo sapiens_hsa045401.36287291
31Long-term depression_Homo sapiens_hsa047301.34791948
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25108534
33Phototransduction_Homo sapiens_hsa047441.22378257
34GnRH signaling pathway_Homo sapiens_hsa049121.20951772
35Estrogen signaling pathway_Homo sapiens_hsa049151.19492421
36Oocyte meiosis_Homo sapiens_hsa041141.18700196
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17583449
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16086007
39Dorso-ventral axis formation_Homo sapiens_hsa043201.10416471
40Ovarian steroidogenesis_Homo sapiens_hsa049131.09829294
41Glioma_Homo sapiens_hsa052141.09754328
42Pancreatic secretion_Homo sapiens_hsa049721.01695590
43Phospholipase D signaling pathway_Homo sapiens_hsa040721.00705595
44Type II diabetes mellitus_Homo sapiens_hsa049300.98811458
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.97853543
46ErbB signaling pathway_Homo sapiens_hsa040120.97508888
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87880692
48Inositol phosphate metabolism_Homo sapiens_hsa005620.87436374
49Circadian rhythm_Homo sapiens_hsa047100.86827642
50Melanogenesis_Homo sapiens_hsa049160.85502871
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82287469
52Ras signaling pathway_Homo sapiens_hsa040140.81492143
53Bile secretion_Homo sapiens_hsa049760.80370005
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.76728863
55Rap1 signaling pathway_Homo sapiens_hsa040150.76298658
56Thyroid hormone synthesis_Homo sapiens_hsa049180.76233003
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75412699
58MAPK signaling pathway_Homo sapiens_hsa040100.73263580
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69712653
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65966146
61Choline metabolism in cancer_Homo sapiens_hsa052310.64602999
62Vitamin B6 metabolism_Homo sapiens_hsa007500.62501984
63VEGF signaling pathway_Homo sapiens_hsa043700.61753950
64mTOR signaling pathway_Homo sapiens_hsa041500.60819739
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60260021
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59952931
67Collecting duct acid secretion_Homo sapiens_hsa049660.53987225
68ABC transporters_Homo sapiens_hsa020100.52516501
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52442703
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52008949
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51944687
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.51890564
73Axon guidance_Homo sapiens_hsa043600.51273777
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46020212
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42431537
76Glucagon signaling pathway_Homo sapiens_hsa049220.40062664
77Cardiac muscle contraction_Homo sapiens_hsa042600.39136212
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39014350
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38835839
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38799766
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38425505
82Alcoholism_Homo sapiens_hsa050340.36220194
83Platelet activation_Homo sapiens_hsa046110.34235641
84Endocytosis_Homo sapiens_hsa041440.33898165
85Fatty acid biosynthesis_Homo sapiens_hsa000610.31092188
86Dilated cardiomyopathy_Homo sapiens_hsa054140.28976151
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.28494272
88Wnt signaling pathway_Homo sapiens_hsa043100.28103711
89Chemokine signaling pathway_Homo sapiens_hsa040620.27626224
90Ether lipid metabolism_Homo sapiens_hsa005650.27358279
91T cell receptor signaling pathway_Homo sapiens_hsa046600.26994072
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25951506
93Non-small cell lung cancer_Homo sapiens_hsa052230.25363359
94Endometrial cancer_Homo sapiens_hsa052130.24891072
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24783155
96Insulin signaling pathway_Homo sapiens_hsa049100.24563415
97Vibrio cholerae infection_Homo sapiens_hsa051100.23455625
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.22909687
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22664657
100Prolactin signaling pathway_Homo sapiens_hsa049170.20833231

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