C4ORF47

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.48045261
2motile cilium assembly (GO:0044458)6.59824315
3intraciliary transport (GO:0042073)5.59412400
4piRNA metabolic process (GO:0034587)5.53277518
5axoneme assembly (GO:0035082)5.51500139
6centriole replication (GO:0007099)5.41119452
7regulation of DNA methylation (GO:0044030)5.31088866
8regulation of meiosis I (GO:0060631)5.06049505
9meiotic cell cycle (GO:0051321)5.03963559
10regulation of cilium movement (GO:0003352)4.88736923
11left/right axis specification (GO:0070986)4.78674692
12retinal cone cell development (GO:0046549)4.71354926
13cilium organization (GO:0044782)4.67114890
14protein localization to cilium (GO:0061512)4.61306266
15left/right pattern formation (GO:0060972)4.60067111
16cilium morphogenesis (GO:0060271)4.54723517
17cilium assembly (GO:0042384)4.54260303
18regulation of female gonad development (GO:2000194)4.50314472
19centriole assembly (GO:0098534)4.46296819
20neuron fate determination (GO:0048664)4.32565623
21DNA methylation involved in gamete generation (GO:0043046)4.28764775
22ventricular system development (GO:0021591)4.12961465
23positive regulation of gastrulation (GO:2000543)4.12694587
24synapsis (GO:0007129)3.95087914
25multicellular organism reproduction (GO:0032504)3.83622698
26nonmotile primary cilium assembly (GO:0035058)3.62785940
27female gamete generation (GO:0007292)3.56003963
28cellular component assembly involved in morphogenesis (GO:0010927)3.47296171
29microtubule-based movement (GO:0007018)3.40669623
30regulation of cell maturation (GO:1903429)3.39089139
31smoothened signaling pathway (GO:0007224)3.37194144
32regulation of acrosome reaction (GO:0060046)3.25912920
33male meiosis (GO:0007140)3.25422718
34male meiosis I (GO:0007141)3.24481681
35determination of left/right symmetry (GO:0007368)3.19136721
36microtubule bundle formation (GO:0001578)3.10181623
37regulation of microtubule-based movement (GO:0060632)3.07331810
38determination of bilateral symmetry (GO:0009855)3.06875904
39regulation of helicase activity (GO:0051095)3.03771496
40pyrimidine-containing compound transmembrane transport (GO:0072531)3.01572870
41specification of symmetry (GO:0009799)3.01114306
42CENP-A containing nucleosome assembly (GO:0034080)2.98455059
43oocyte development (GO:0048599)2.97892691
44microtubule severing (GO:0051013)2.95127564
45chromosome organization involved in meiosis (GO:0070192)2.94507508
46lateral sprouting from an epithelium (GO:0060601)2.92012077
47gene silencing by RNA (GO:0031047)2.91169994
48sperm motility (GO:0030317)2.89302837
49cell projection assembly (GO:0030031)2.89227308
50chromatin remodeling at centromere (GO:0031055)2.84959623
51genitalia morphogenesis (GO:0035112)2.82276225
52photoreceptor cell maintenance (GO:0045494)2.80654939
53negative regulation of reproductive process (GO:2000242)2.80304880
54somatic diversification of immune receptors via somatic mutation (GO:0002566)2.79409484
55somatic hypermutation of immunoglobulin genes (GO:0016446)2.79409484
56regulation of histone H3-K9 methylation (GO:0051570)2.75494222
57primitive streak formation (GO:0090009)2.73872585
58sperm capacitation (GO:0048240)2.73535939
59synaptonemal complex assembly (GO:0007130)2.72744284
60positive regulation of mitotic sister chromatid separation (GO:1901970)2.68675058
61positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.68675058
62positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.68675058
63meiotic cell cycle process (GO:1903046)2.68479333
64spermatid development (GO:0007286)2.67277888
65relaxation of smooth muscle (GO:0044557)2.67091360
66intra-S DNA damage checkpoint (GO:0031573)2.65916576
67spermatid nucleus differentiation (GO:0007289)2.64632689
68vitamin transmembrane transport (GO:0035461)2.63049054
69mismatch repair (GO:0006298)2.62961970
70reciprocal DNA recombination (GO:0035825)2.62647396
71reciprocal meiotic recombination (GO:0007131)2.62647396
72meiosis I (GO:0007127)2.62297438
73resolution of meiotic recombination intermediates (GO:0000712)2.61548520
74fertilization (GO:0009566)2.61445390
75positive regulation of histone H3-K4 methylation (GO:0051571)2.59453174
76microtubule depolymerization (GO:0007019)2.59172498
77synaptonemal complex organization (GO:0070193)2.54338520
78regulation of steroid hormone secretion (GO:2000831)2.54064504
79negative regulation of DNA recombination (GO:0045910)2.53769077
80mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.52433660
81establishment of chromosome localization (GO:0051303)2.50259833
82lateral ventricle development (GO:0021670)2.48723158
83somite rostral/caudal axis specification (GO:0032525)2.46521141
84presynaptic membrane assembly (GO:0097105)2.46071050
85microtubule polymerization or depolymerization (GO:0031109)2.44804472
86paraxial mesoderm development (GO:0048339)2.41721786
87single fertilization (GO:0007338)2.41582681
88photoreceptor cell development (GO:0042461)2.41179081
89histone exchange (GO:0043486)2.40007077
90glycine transport (GO:0015816)2.38338253
91meiotic nuclear division (GO:0007126)2.38149409
92organelle assembly (GO:0070925)2.37651993
93protein localization to kinetochore (GO:0034501)2.37371159
94establishment of planar polarity (GO:0001736)2.37087986
95establishment of tissue polarity (GO:0007164)2.37087986
96nucleoside diphosphate phosphorylation (GO:0006165)2.37076245
97axonemal dynein complex assembly (GO:0070286)10.5905080
98epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.4161657
99cilium movement (GO:0003341)10.2556152
100epithelial cilium movement (GO:0003351)10.0070972

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.33203037
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.76361550
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.60805546
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.26253099
5GBX2_23144817_ChIP-Seq_PC3_Human2.99644624
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.57709549
7VDR_22108803_ChIP-Seq_LS180_Human2.29932587
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27866674
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.17089637
10EWS_26573619_Chip-Seq_HEK293_Human2.10769628
11FUS_26573619_Chip-Seq_HEK293_Human2.10354613
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.07632513
13ZNF274_21170338_ChIP-Seq_K562_Hela2.06977335
14P300_19829295_ChIP-Seq_ESCs_Human2.03052864
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00553074
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.93046983
17TAF15_26573619_Chip-Seq_HEK293_Human1.92850200
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88252117
19TOP2B_26459242_ChIP-Seq_MCF-7_Human1.84652640
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.77108603
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72309256
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.67297241
23HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.63441416
24SMAD4_21799915_ChIP-Seq_A2780_Human1.63267375
25IRF1_19129219_ChIP-ChIP_H3396_Human1.61200483
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58940885
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.58328465
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55992935
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55655869
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54881849
31RNF2_27304074_Chip-Seq_NSC_Mouse1.49489864
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49304091
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.48811189
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48208418
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47901727
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45002037
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44029243
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.43979901
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42896465
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42791176
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42526663
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.42467479
43AR_25329375_ChIP-Seq_VCAP_Human1.39772397
44CBP_20019798_ChIP-Seq_JUKART_Human1.39659546
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39659546
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38789115
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38653181
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38653181
49CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37950583
50STAT3_23295773_ChIP-Seq_U87_Human1.36889276
51TCF4_23295773_ChIP-Seq_U87_Human1.35690825
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34144125
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34117678
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33141086
55TP53_16413492_ChIP-PET_HCT116_Human1.30612760
56KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.30534208
57KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.30534208
58KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.30534208
59ER_23166858_ChIP-Seq_MCF-7_Human1.30331163
60KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.29838509
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29783330
62BCAT_22108803_ChIP-Seq_LS180_Human1.29440777
63RUNX2_22187159_ChIP-Seq_PCA_Human1.28855761
64FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27884204
65EST1_17652178_ChIP-ChIP_JURKAT_Human1.26358142
66TAL1_26923725_Chip-Seq_HPCs_Mouse1.25341273
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22364459
68TCF4_22108803_ChIP-Seq_LS180_Human1.18985718
69MYC_18940864_ChIP-ChIP_HL60_Human1.18126198
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17086503
71GATA1_26923725_Chip-Seq_HPCs_Mouse1.15802176
72TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14655704
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13792676
74IGF1R_20145208_ChIP-Seq_DFB_Human1.12152919
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.09016749
76LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08879527
77SMAD4_21741376_ChIP-Seq_EPCs_Human1.08852628
78FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07381082
79FOXA1_25329375_ChIP-Seq_VCAP_Human1.07381082
80LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07022520
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06464603
82OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06312147
83ELK1_19687146_ChIP-ChIP_HELA_Human1.05759260
84SOX2_19829295_ChIP-Seq_ESCs_Human1.05718045
85NANOG_19829295_ChIP-Seq_ESCs_Human1.05718045
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.02577477
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.02483192
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02460792
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02310546
90STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02305036
91TP53_22573176_ChIP-Seq_HFKS_Human1.02162427
92CBX2_27304074_Chip-Seq_ESCs_Mouse1.00272210
93CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98828846
94CREB1_15753290_ChIP-ChIP_HEK293T_Human0.98558670
95HTT_18923047_ChIP-ChIP_STHdh_Human0.97444398
96TP53_18474530_ChIP-ChIP_U2OS_Human0.95358770
97EP300_21415370_ChIP-Seq_HL-1_Mouse0.94549048
98DROSHA_22980978_ChIP-Seq_HELA_Human0.93033562
99CBP_21632823_ChIP-Seq_H3396_Human0.92903544
100EZH2_27304074_Chip-Seq_ESCs_Mouse0.92273462

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect4.27877317
2MP0008789_abnormal_olfactory_epithelium4.16122972
3MP0008877_abnormal_DNA_methylation3.98694895
4MP0006292_abnormal_olfactory_placode3.74908065
5MP0002653_abnormal_ependyma_morphology3.66854762
6MP0005394_taste/olfaction_phenotype3.43704269
7MP0005499_abnormal_olfactory_system3.43704269
8MP0001984_abnormal_olfaction3.29056826
9MP0010030_abnormal_orbit_morphology3.17590552
10MP0003136_yellow_coat_color2.98794548
11MP0000566_synostosis2.38111664
12MP0008875_abnormal_xenobiotic_pharmacok1.95737229
13MP0003890_abnormal_embryonic-extraembry1.95205655
14MP0001293_anophthalmia1.87384298
15MP0005395_other_phenotype1.77530155
16MP0009379_abnormal_foot_pigmentation1.72159803
17MP0002233_abnormal_nose_morphology1.67215552
18MP0001929_abnormal_gametogenesis1.67213087
19MP0004133_heterotaxia1.65400470
20MP0002234_abnormal_pharynx_morphology1.65233453
21MP0002638_abnormal_pupillary_reflex1.64004735
22MP0006276_abnormal_autonomic_nervous1.63210272
23MP0005551_abnormal_eye_electrophysiolog1.62542615
24MP0000049_abnormal_middle_ear1.61381737
25MP0000631_abnormal_neuroendocrine_gland1.61209447
26MP0006072_abnormal_retinal_apoptosis1.57228851
27MP0002210_abnormal_sex_determination1.56820392
28MP0003122_maternal_imprinting1.55804749
29MP0002928_abnormal_bile_duct1.55397660
30MP0002160_abnormal_reproductive_system1.54557579
31MP0002139_abnormal_hepatobiliary_system1.46712710
32MP0004142_abnormal_muscle_tone1.45113462
33MP0000026_abnormal_inner_ear1.39651234
34MP0003195_calcinosis1.39420954
35MP0003878_abnormal_ear_physiology1.37711772
36MP0005377_hearing/vestibular/ear_phenot1.37711772
37MP0003121_genomic_imprinting1.37311774
38MP0003880_abnormal_central_pattern1.37066924
39MP0002102_abnormal_ear_morphology1.35269812
40MP0005171_absent_coat_pigmentation1.34768871
41MP0000383_abnormal_hair_follicle1.30266282
42MP0003698_abnormal_male_reproductive1.29365360
43MP0000653_abnormal_sex_gland1.28484802
44MP0005646_abnormal_pituitary_gland1.23926280
45MP0005410_abnormal_fertilization1.19354759
46MP0001324_abnormal_eye_pigmentation1.17978597
47MP0005253_abnormal_eye_physiology1.17640152
48MP0001485_abnormal_pinna_reflex1.15278790
49MP0003119_abnormal_digestive_system1.15134623
50MP0002272_abnormal_nervous_system1.14556947
51MP0002161_abnormal_fertility/fecundity1.12811130
52MP0005360_urolithiasis1.11830411
53MP0008058_abnormal_DNA_repair1.09907708
54MP0001145_abnormal_male_reproductive1.09499730
55MP0002938_white_spotting1.09054760
56MP0004043_abnormal_pH_regulation1.08649848
57MP0000762_abnormal_tongue_morphology1.08588641
58MP0003937_abnormal_limbs/digits/tail_de1.07722737
59MP0000372_irregular_coat_pigmentation1.06997170
60MP0010678_abnormal_skin_adnexa1.05960473
61MP0003699_abnormal_female_reproductive1.05558912
62MP0001529_abnormal_vocalization1.04632542
63MP0001963_abnormal_hearing_physiology1.04146647
64MP0003879_abnormal_hair_cell1.03608579
65MP0002282_abnormal_trachea_morphology1.03490358
66MP0000778_abnormal_nervous_system1.02783526
67MP0002751_abnormal_autonomic_nervous1.00845939
68MP0001286_abnormal_eye_development0.99794531
69MP0000427_abnormal_hair_cycle0.98134285
70MP0004019_abnormal_vitamin_homeostasis0.97860708
71MP0002734_abnormal_mechanical_nocicepti0.94806662
72MP0002277_abnormal_respiratory_mucosa0.92080231
73MP0005389_reproductive_system_phenotype0.91211816
74MP0005195_abnormal_posterior_eye0.89639765
75MP0003938_abnormal_ear_development0.89624749
76MP0003755_abnormal_palate_morphology0.87380023
77MP0005248_abnormal_Harderian_gland0.86115733
78MP0005503_abnormal_tendon_morphology0.83915940
79MP0001486_abnormal_startle_reflex0.82264166
80MP0005391_vision/eye_phenotype0.81582072
81MP0009745_abnormal_behavioral_response0.81496075
82MP0002752_abnormal_somatic_nervous0.81415969
83MP0001502_abnormal_circadian_rhythm0.80249027
84MP0002132_abnormal_respiratory_system0.78675441
85MP0003950_abnormal_plasma_membrane0.75738880
86MP0001119_abnormal_female_reproductive0.75109607
87MP0009780_abnormal_chondrocyte_physiolo0.74461404
88MP0003861_abnormal_nervous_system0.74411394
89MP0002557_abnormal_social/conspecific_i0.74263646
90MP0003252_abnormal_bile_duct0.73270045
91MP0009697_abnormal_copulation0.72955379
92MP0005085_abnormal_gallbladder_physiolo0.72769589
93MP0003787_abnormal_imprinting0.71484739
94MP0002572_abnormal_emotion/affect_behav0.70723107
95MP0003186_abnormal_redox_activity0.70156834
96MP0003011_delayed_dark_adaptation0.68696623
97MP0008995_early_reproductive_senescence0.68666163
98MP0008932_abnormal_embryonic_tissue0.68583667
99MP0002697_abnormal_eye_size0.66141228
100MP0001346_abnormal_lacrimal_gland0.64408848

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)8.12556607
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.07566548
3Abnormal respiratory motile cilium physiology (HP:0012261)7.75739103
4Abnormal respiratory epithelium morphology (HP:0012253)7.33124360
5Abnormal respiratory motile cilium morphology (HP:0005938)7.33124360
6Dynein arm defect of respiratory motile cilia (HP:0012255)7.10451447
7Absent/shortened dynein arms (HP:0200106)7.10451447
8Rhinitis (HP:0012384)6.99667695
9Chronic bronchitis (HP:0004469)4.57318172
10Bronchiectasis (HP:0002110)4.48590337
11Supernumerary spleens (HP:0009799)4.40387468
12Pancreatic fibrosis (HP:0100732)4.38970669
13True hermaphroditism (HP:0010459)4.17472596
14Pancreatic cysts (HP:0001737)4.04677431
15Molar tooth sign on MRI (HP:0002419)3.80929429
16Abnormality of midbrain morphology (HP:0002418)3.80929429
17Medial flaring of the eyebrow (HP:0010747)3.69144970
18Nephronophthisis (HP:0000090)3.58474111
19Aplasia/Hypoplasia of the tongue (HP:0010295)3.32217945
20Infertility (HP:0000789)3.27038013
21Occipital encephalocele (HP:0002085)3.25008547
22Gait imbalance (HP:0002141)3.23724415
23Median cleft lip (HP:0000161)3.21321065
24Congenital primary aphakia (HP:0007707)3.21199491
25Cystic liver disease (HP:0006706)3.14654581
26Nasal polyposis (HP:0100582)3.13645523
27Septo-optic dysplasia (HP:0100842)3.05816399
28Oligodactyly (hands) (HP:0001180)2.93475821
29Abnormality of the renal medulla (HP:0100957)2.84644025
30Chronic sinusitis (HP:0011109)2.83470548
31Nephrogenic diabetes insipidus (HP:0009806)2.81738240
32Postaxial foot polydactyly (HP:0001830)2.77972483
33Anencephaly (HP:0002323)2.77228555
34Chronic hepatic failure (HP:0100626)2.74135711
35Abdominal situs inversus (HP:0003363)2.60906152
36Abnormality of abdominal situs (HP:0011620)2.60906152
37Genital tract atresia (HP:0001827)2.60049698
38Postaxial hand polydactyly (HP:0001162)2.55910760
39Tubular atrophy (HP:0000092)2.53953353
40Abnormal biliary tract physiology (HP:0012439)2.52123615
41Bile duct proliferation (HP:0001408)2.52123615
42Abnormality of the labia minora (HP:0012880)2.48205890
43Short tibia (HP:0005736)2.47472521
44Congenital hepatic fibrosis (HP:0002612)2.46961745
45Vaginal atresia (HP:0000148)2.41917221
46Abnormality of the nasal mucosa (HP:0000433)2.38396433
47Absent septum pellucidum (HP:0001331)2.38176263
48Preaxial hand polydactyly (HP:0001177)2.31780211
49Recurrent sinusitis (HP:0011108)2.29848815
50Male infertility (HP:0003251)2.29640331
51Aplasia/Hypoplasia of the tibia (HP:0005772)2.29174248
52Sclerocornea (HP:0000647)2.27693981
53Tubulointerstitial nephritis (HP:0001970)2.25071167
54Poor coordination (HP:0002370)2.21589777
55Bronchitis (HP:0012387)2.19176818
56Male pseudohermaphroditism (HP:0000037)2.07582877
57Oligodactyly (HP:0012165)2.05154141
58Oculomotor apraxia (HP:0000657)1.95620172
59Abnormality of the septum pellucidum (HP:0007375)1.94098463
60Maternal diabetes (HP:0009800)1.90926388
61Abnormality of the renal cortex (HP:0011035)1.84444310
62Optic nerve hypoplasia (HP:0000609)1.79858142
63Abnormal gallbladder physiology (HP:0012438)1.77621341
64Cholecystitis (HP:0001082)1.77621341
65Bifid tongue (HP:0010297)1.77112489
66Osteomalacia (HP:0002749)1.75350936
67Facial hemangioma (HP:0000329)1.74901278
68Aplasia/Hypoplasia of the lens (HP:0008063)1.72089422
69Holoprosencephaly (HP:0001360)1.68870926
70Azoospermia (HP:0000027)1.68029033
71Aganglionic megacolon (HP:0002251)1.65801197
72Hyperactive renin-angiotensin system (HP:0000841)1.65693410
73Multicystic kidney dysplasia (HP:0000003)1.65351927
74Anophthalmia (HP:0000528)1.65069270
75Recurrent otitis media (HP:0000403)1.63386738
76Broad foot (HP:0001769)1.62662147
77Tubulointerstitial abnormality (HP:0001969)1.62063417
78Abnormality of the fovea (HP:0000493)1.59105770
79Furrowed tongue (HP:0000221)1.59073597
80Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.56951155
81Hypoplasia of the fovea (HP:0007750)1.55404248
82Aplasia/Hypoplasia of the fovea (HP:0008060)1.55404248
83Narrow forehead (HP:0000341)1.55330682
84Hyperglycinemia (HP:0002154)1.51021291
85Agnosia (HP:0010524)1.50643518
86Polydipsia (HP:0001959)1.50562920
87Abnormal drinking behavior (HP:0030082)1.50562920
88Decreased testicular size (HP:0008734)1.49563574
89Retinitis pigmentosa (HP:0000510)1.47814070
90Reticulocytopenia (HP:0001896)1.47041603
91Stenosis of the external auditory canal (HP:0000402)1.46736170
92Prominent nasal bridge (HP:0000426)1.45591210
93Neoplasm of the oral cavity (HP:0100649)1.43874628
94Decreased central vision (HP:0007663)1.43098831
95Aplasia/Hypoplasia of the uvula (HP:0010293)1.42320846
96Specific learning disability (HP:0001328)1.40155602
97Rhabdomyosarcoma (HP:0002859)1.40126050
98Type II lissencephaly (HP:0007260)1.39638073
99Dandy-Walker malformation (HP:0001305)1.39285669
100Meckel diverticulum (HP:0002245)1.38327603

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.33940837
2TNIK3.31886174
3MST42.79676897
4ARAF2.50613385
5MAP4K22.50572286
6WNK32.49406081
7MAP3K92.30097956
8NEK62.12274449
9TTK2.04976516
10PNCK2.02666623
11STK241.96721313
12VRK11.88238176
13ZAK1.76371822
14MAP3K41.75746612
15MET1.73248138
16TAOK31.69743144
17NTRK21.56129740
18BCR1.53134856
19BMPR1B1.49434210
20CDK91.47320901
21TLK11.39438329
22EPHA41.39038181
23EIF2AK31.34446179
24AURKA1.33596947
25STK391.30560003
26TRIM281.28079402
27CDC71.26535431
28MAP2K71.24286428
29EPHB21.23796059
30NUAK11.23137499
31PLK31.21042139
32PRKCI1.18547108
33BRAF1.18455154
34PLK11.15725136
35MAP3K131.12061243
36MUSK1.09797732
37TIE11.07475130
38MAPK131.06882300
39CDK191.04625399
40ADRBK21.01029968
41INSRR1.00130263
42TGFBR10.95271800
43RAF10.94472335
44PINK10.94077429
45STK160.93438365
46WEE10.90122378
47BRSK20.89181375
48MARK10.88774422
49VRK20.88626475
50MOS0.88200470
51BCKDK0.87724432
52PASK0.87694322
53PTK2B0.87487736
54STK30.86610387
55NEK90.86114081
56OXSR10.85197763
57TSSK60.85128321
58CASK0.84222204
59GRK10.83460624
60DYRK20.83089110
61NME10.81513935
62NEK20.78728737
63KSR10.77210281
64ERBB30.77135163
65CSNK1G10.74805553
66STK38L0.72674451
67NLK0.72482776
68NTRK30.71584989
69CAMK2A0.64910701
70DYRK30.63620685
71CSNK1G20.63610542
72KSR20.61240075
73PRKG10.60508273
74PLK20.59318963
75SRPK10.58993839
76WNK40.58229025
77MKNK10.57702465
78CDK80.57247758
79PRKCG0.56030416
80MKNK20.54993342
81CSNK1G30.54239063
82PKN10.53727166
83PRKCE0.53116668
84PAK40.52698458
85PRKACA0.51334499
86MAP3K120.50080015
87ACVR1B0.45458722
88CSNK1D0.43079358
89CHEK20.42938935
90FRK0.41732107
91CSNK1A1L0.40943291
92DYRK1A0.39738788
93FGFR10.39608549
94AURKB0.39395704
95ATM0.37654845
96EPHA20.37119586
97BRSK10.35081897
98ADRBK10.33382064
99ATR0.33184830
100CDK30.31999319

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.04581439
2Basal transcription factors_Homo sapiens_hsa030223.03288279
3Huntingtons disease_Homo sapiens_hsa050162.87892718
4Oxidative phosphorylation_Homo sapiens_hsa001902.64452126
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.50385051
6Caffeine metabolism_Homo sapiens_hsa002322.48726480
7Ribosome_Homo sapiens_hsa030102.36202837
8Parkinsons disease_Homo sapiens_hsa050122.25875193
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.15316898
10Protein export_Homo sapiens_hsa030602.10049711
11Fanconi anemia pathway_Homo sapiens_hsa034602.08939927
12Phototransduction_Homo sapiens_hsa047442.02134587
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95212346
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.93310698
15Nicotine addiction_Homo sapiens_hsa050331.90844367
16Homologous recombination_Homo sapiens_hsa034401.87550174
17RNA degradation_Homo sapiens_hsa030181.87318859
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.82598584
19Propanoate metabolism_Homo sapiens_hsa006401.76968120
20Cardiac muscle contraction_Homo sapiens_hsa042601.65319215
21Chemical carcinogenesis_Homo sapiens_hsa052041.64330304
22Nucleotide excision repair_Homo sapiens_hsa034201.60483772
23Cell cycle_Homo sapiens_hsa041101.57707331
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.55348883
25Alzheimers disease_Homo sapiens_hsa050101.50931816
26Oocyte meiosis_Homo sapiens_hsa041141.41692420
27Folate biosynthesis_Homo sapiens_hsa007901.39367285
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.38124396
29RNA polymerase_Homo sapiens_hsa030201.37361529
30Basal cell carcinoma_Homo sapiens_hsa052171.36212394
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31120001
32Linoleic acid metabolism_Homo sapiens_hsa005911.25338980
33Olfactory transduction_Homo sapiens_hsa047401.25333370
34Steroid biosynthesis_Homo sapiens_hsa001001.22771355
35Glutathione metabolism_Homo sapiens_hsa004801.20578567
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18816864
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14478051
38Circadian rhythm_Homo sapiens_hsa047101.12843141
39Hedgehog signaling pathway_Homo sapiens_hsa043401.12494205
40Histidine metabolism_Homo sapiens_hsa003401.12074266
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11679570
42Tyrosine metabolism_Homo sapiens_hsa003501.05426245
43Ovarian steroidogenesis_Homo sapiens_hsa049131.04331396
44Base excision repair_Homo sapiens_hsa034101.01927831
45Phenylalanine metabolism_Homo sapiens_hsa003601.01123254
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00152192
47Nitrogen metabolism_Homo sapiens_hsa009100.99164065
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97727645
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97648019
50Taste transduction_Homo sapiens_hsa047420.95761011
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95206537
52RNA transport_Homo sapiens_hsa030130.95061718
53Butanoate metabolism_Homo sapiens_hsa006500.93368063
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92797433
55Fatty acid elongation_Homo sapiens_hsa000620.91111867
56Retinol metabolism_Homo sapiens_hsa008300.90927242
57Peroxisome_Homo sapiens_hsa041460.89321910
58Vitamin digestion and absorption_Homo sapiens_hsa049770.88731453
59beta-Alanine metabolism_Homo sapiens_hsa004100.88181048
60Pyruvate metabolism_Homo sapiens_hsa006200.85992004
61GABAergic synapse_Homo sapiens_hsa047270.84806889
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.82687813
63Purine metabolism_Homo sapiens_hsa002300.81045121
64Hippo signaling pathway_Homo sapiens_hsa043900.78906026
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76920671
66ABC transporters_Homo sapiens_hsa020100.72989719
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71629411
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69407167
69Dorso-ventral axis formation_Homo sapiens_hsa043200.69249614
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.68124596
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68038526
72Metabolic pathways_Homo sapiens_hsa011000.66969713
73DNA replication_Homo sapiens_hsa030300.64662818
74Arginine and proline metabolism_Homo sapiens_hsa003300.63449712
75Regulation of autophagy_Homo sapiens_hsa041400.63107453
76Morphine addiction_Homo sapiens_hsa050320.62090805
77TGF-beta signaling pathway_Homo sapiens_hsa043500.60506164
78Proteasome_Homo sapiens_hsa030500.57404624
79p53 signaling pathway_Homo sapiens_hsa041150.57302603
80Serotonergic synapse_Homo sapiens_hsa047260.55593916
81Wnt signaling pathway_Homo sapiens_hsa043100.52719651
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51921489
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51721864
84Arachidonic acid metabolism_Homo sapiens_hsa005900.49345966
85Mineral absorption_Homo sapiens_hsa049780.48820519
86Spliceosome_Homo sapiens_hsa030400.46923905
87Bile secretion_Homo sapiens_hsa049760.46884773
88Tryptophan metabolism_Homo sapiens_hsa003800.46149208
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.44899336
90Ether lipid metabolism_Homo sapiens_hsa005650.44505708
91Cocaine addiction_Homo sapiens_hsa050300.43716097
92Axon guidance_Homo sapiens_hsa043600.42283127
93Non-homologous end-joining_Homo sapiens_hsa034500.40820644
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40307435
95Glutamatergic synapse_Homo sapiens_hsa047240.40010144
96Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.39081839
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36959830
98Melanogenesis_Homo sapiens_hsa049160.35991157
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35715471
100Gap junction_Homo sapiens_hsa045400.34612933

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