C4ORF45

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retinal rod cell development (GO:0046548)5.42983625
2phenol-containing compound biosynthetic process (GO:0046189)4.99442553
3developmental pigmentation (GO:0048066)4.79696958
4melanosome organization (GO:0032438)4.74297566
5piRNA metabolic process (GO:0034587)4.73602046
6pigment cell differentiation (GO:0050931)4.65167420
7inositol phosphate catabolic process (GO:0071545)4.61023008
8cullin deneddylation (GO:0010388)4.57951658
9pigment granule organization (GO:0048753)4.44228990
10melanocyte differentiation (GO:0030318)4.42908093
11regulation of integrin-mediated signaling pathway (GO:2001044)4.36848339
12regulation of meiosis I (GO:0060631)4.36098028
13phosphorylated carbohydrate dephosphorylation (GO:0046838)4.14873725
14inositol phosphate dephosphorylation (GO:0046855)4.14873725
15proteasome assembly (GO:0043248)4.04381152
16polyol catabolic process (GO:0046174)3.97887977
17protein deneddylation (GO:0000338)3.85192377
18pigment biosynthetic process (GO:0046148)3.83417887
19G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.77937920
20negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.70335609
21ketone body metabolic process (GO:1902224)3.64148610
22neuroepithelial cell differentiation (GO:0060563)3.57611132
23signal peptide processing (GO:0006465)3.55193250
24detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.47849310
25retinal cone cell development (GO:0046549)3.46759721
26cornea development in camera-type eye (GO:0061303)3.42606336
27centriole replication (GO:0007099)3.41541659
28DNA methylation involved in gamete generation (GO:0043046)3.39511512
29negative regulation of JUN kinase activity (GO:0043508)3.38284538
30fusion of sperm to egg plasma membrane (GO:0007342)3.30167341
31kinetochore assembly (GO:0051382)3.30082746
32secondary metabolic process (GO:0019748)3.29747027
33pigment metabolic process (GO:0042440)3.29654963
34synapsis (GO:0007129)3.24538929
35melanosome transport (GO:0032402)3.22534140
36acrosome reaction (GO:0007340)3.14162803
37kinetochore organization (GO:0051383)3.12673226
38pigment granule transport (GO:0051904)3.10168054
39muscle cell cellular homeostasis (GO:0046716)3.06849000
40tyrosine metabolic process (GO:0006570)3.06023237
41establishment of melanosome localization (GO:0032401)3.01017343
42male meiosis (GO:0007140)3.00450205
43sperm motility (GO:0030317)3.00068858
44meiotic cell cycle (GO:0051321)2.99481529
45response to pheromone (GO:0019236)2.99442442
46regulation of mitotic spindle checkpoint (GO:1903504)2.99043540
47regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.99043540
48positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.97516904
49positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.97516904
50positive regulation of mitotic sister chromatid separation (GO:1901970)2.97516904
51pigmentation (GO:0043473)2.93607159
52establishment of pigment granule localization (GO:0051905)2.90124426
53metaphase plate congression (GO:0051310)2.89975235
54melanosome localization (GO:0032400)2.85925756
55negative regulation of interleukin-1 beta production (GO:0032691)2.85889221
56mitotic metaphase plate congression (GO:0007080)2.84074189
57establishment of chromosome localization (GO:0051303)2.82139481
58regulation of female gonad development (GO:2000194)2.78708990
59pigment granule localization (GO:0051875)2.76507936
60spermatid development (GO:0007286)2.74743217
61regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.72317451
62cellular response to superoxide (GO:0071451)2.72131560
63cellular response to oxygen radical (GO:0071450)2.72131560
64removal of superoxide radicals (GO:0019430)2.72131560
65multicellular organism reproduction (GO:0032504)2.71711594
66attachment of spindle microtubules to kinetochore (GO:0008608)2.69693644
67histone exchange (GO:0043486)2.67135914
68eye photoreceptor cell development (GO:0042462)2.66004533
69photoreceptor cell development (GO:0042461)2.65922343
70glial cell proliferation (GO:0014009)2.64770893
71regulation of DNA endoreduplication (GO:0032875)2.64354297
72protein K11-linked deubiquitination (GO:0035871)2.63905543
73regulation of cilium movement (GO:0003352)2.63781829
74calcium-mediated signaling using intracellular calcium source (GO:0035584)2.62192685
75regulation of non-canonical Wnt signaling pathway (GO:2000050)2.61537158
76regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.60448197
77behavioral response to ethanol (GO:0048149)2.59391211
78synaptic transmission, cholinergic (GO:0007271)2.59155755
79regulation of centriole replication (GO:0046599)2.58701609
80microtubule depolymerization (GO:0007019)2.58573260
81endosome to pigment granule transport (GO:0043485)2.57579986
82endosome to melanosome transport (GO:0035646)2.57579986
83negative regulation of DNA-dependent DNA replication (GO:2000104)2.57140621
84regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.55843657
85positive regulation of chromosome segregation (GO:0051984)2.54223178
86establishment of protein localization to Golgi (GO:0072600)2.53231500
87protein targeting to Golgi (GO:0000042)2.52935231
88neural tube formation (GO:0001841)2.51592923
89male meiosis I (GO:0007141)2.50926344
90nucleotide transmembrane transport (GO:1901679)2.48944161
91sister chromatid cohesion (GO:0007062)2.45046968
92Golgi to endosome transport (GO:0006895)2.44856626
93nitric oxide biosynthetic process (GO:0006809)2.44482297
94regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.44423215
95regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.44423215
96lactate metabolic process (GO:0006089)2.44202260
97spindle checkpoint (GO:0031577)2.43898074
98melanin biosynthetic process (GO:0042438)11.8495154
99melanin metabolic process (GO:0006582)10.7060465
100secondary metabolite biosynthetic process (GO:0044550)10.4372543

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.11568512
2POU3F2_20337985_ChIP-ChIP_501MEL_Human3.07659974
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.95645772
4FUS_26573619_Chip-Seq_HEK293_Human2.77679768
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.71496241
6GBX2_23144817_ChIP-Seq_PC3_Human2.69525948
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.60046467
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.47939888
9ZNF274_21170338_ChIP-Seq_K562_Hela2.43701381
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.28090733
11* P300_19829295_ChIP-Seq_ESCs_Human2.27719330
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.22396953
13* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.13903423
14VDR_22108803_ChIP-Seq_LS180_Human2.09546731
15TAF15_26573619_Chip-Seq_HEK293_Human2.07334775
16CBP_20019798_ChIP-Seq_JUKART_Human1.88445182
17IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.88445182
18UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.83728942
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.82272639
20EWS_26573619_Chip-Seq_HEK293_Human1.81109255
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78240021
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.76494549
23SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74289228
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74044431
25ER_23166858_ChIP-Seq_MCF-7_Human1.71623932
26SMAD3_21741376_ChIP-Seq_EPCs_Human1.70363654
27SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.69292624
28EZH2_27294783_Chip-Seq_NPCs_Mouse1.66133185
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65938867
30SMAD4_21799915_ChIP-Seq_A2780_Human1.64188816
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63686115
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.60586282
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60043037
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.57106454
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56556849
36EZH2_22144423_ChIP-Seq_EOC_Human1.55624231
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54752783
38ELK1_19687146_ChIP-ChIP_HELA_Human1.52018669
39FOXM1_23109430_ChIP-Seq_U2OS_Human1.51286533
40FOXM1_26456572_ChIP-Seq_MCF-7_Human1.48311781
41STAT3_23295773_ChIP-Seq_U87_Human1.46789584
42NANOG_19829295_ChIP-Seq_ESCs_Human1.45049209
43SOX2_19829295_ChIP-Seq_ESCs_Human1.45049209
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44709591
45* AR_25329375_ChIP-Seq_VCAP_Human1.44696397
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.43692516
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42869855
48TCF4_23295773_ChIP-Seq_U87_Human1.41941818
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.38198996
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37907099
51KLF5_20875108_ChIP-Seq_MESCs_Mouse1.36617149
52BCAT_22108803_ChIP-Seq_LS180_Human1.36198092
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35965346
54RUNX2_22187159_ChIP-Seq_PCA_Human1.34465782
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.33625578
56RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.33099550
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33030847
58FOXA1_21572438_ChIP-Seq_LNCaP_Human1.32251505
59E2F4_17652178_ChIP-ChIP_JURKAT_Human1.31146640
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31007073
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31007073
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30141684
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29569117
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28764365
65CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.28437219
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.27772224
67* TCF4_22108803_ChIP-Seq_LS180_Human1.27479710
68CRX_20693478_ChIP-Seq_RETINA_Mouse1.27039879
69SMAD4_21741376_ChIP-Seq_EPCs_Human1.26627038
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26393656
71* CJUN_26792858_Chip-Seq_BT549_Human1.24958322
72TAL1_26923725_Chip-Seq_HPCs_Mouse1.23876045
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23391212
74CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21754256
75* CDX2_22108803_ChIP-Seq_LS180_Human1.20239469
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17096138
77ESR1_20079471_ChIP-ChIP_T-47D_Human1.14424938
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13662320
79FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.13505706
80JUN_21703547_ChIP-Seq_K562_Human1.12767894
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11630030
82SALL4_22934838_ChIP-ChIP_CD34+_Human1.09488124
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.09253270
84AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08435473
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08396157
86NCOR_22424771_ChIP-Seq_293T_Human1.06809958
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06673183
88* FOXA1_25329375_ChIP-Seq_VCAP_Human1.05878178
89* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05878178
90OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05502428
91SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03816085
92CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03165643
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02730500
94P53_22387025_ChIP-Seq_ESCs_Mouse1.02287755
95SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01518375
96PRDM14_20953172_ChIP-Seq_ESCs_Human1.01015851
97E2F1_18555785_Chip-Seq_ESCs_Mouse1.00414335
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00018553
99PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99017649
100TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97781545

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation9.53527411
2MP0003136_yellow_coat_color5.61048531
3MP0005408_hypopigmentation5.01476017
4MP0005075_abnormal_melanosome_morpholog4.94137133
5MP0005171_absent_coat_pigmentation4.59446889
6MP0000015_abnormal_ear_pigmentation4.24600088
7MP0003950_abnormal_plasma_membrane3.05848192
8MP0002095_abnormal_skin_pigmentation2.95114108
9MP0003806_abnormal_nucleotide_metabolis2.90537676
10MP0000371_diluted_coat_color2.82725062
11MP0003646_muscle_fatigue2.61795192
12MP0002102_abnormal_ear_morphology2.61487196
13MP0003718_maternal_effect2.45625461
14MP0001324_abnormal_eye_pigmentation2.45543456
15MP0005174_abnormal_tail_pigmentation2.30875659
16MP0004381_abnormal_hair_follicle2.27424062
17MP0002090_abnormal_vision2.14869682
18MP0000569_abnormal_digit_pigmentation2.07552160
19MP0002938_white_spotting1.85401596
20MP0005253_abnormal_eye_physiology1.80062635
21MP0002075_abnormal_coat/hair_pigmentati1.69272565
22MP0005248_abnormal_Harderian_gland1.62124952
23MP0005377_hearing/vestibular/ear_phenot1.51172995
24MP0003878_abnormal_ear_physiology1.51172995
25MP0005410_abnormal_fertilization1.50274064
26MP0005551_abnormal_eye_electrophysiolog1.34848535
27MP0010094_abnormal_chromosome_stability1.33296956
28MP0001186_pigmentation_phenotype1.29552570
29MP0005257_abnormal_intraocular_pressure1.26805976
30MP0002638_abnormal_pupillary_reflex1.23745983
31MP0005187_abnormal_penis_morphology1.18106058
32MP0005395_other_phenotype1.14057517
33MP0000427_abnormal_hair_cycle1.14041714
34MP0006054_spinal_hemorrhage1.07579884
35MP0008058_abnormal_DNA_repair1.06368250
36MP0005197_abnormal_uvea_morphology1.04148547
37MP0003186_abnormal_redox_activity1.03991972
38MP0002822_catalepsy1.00482815
39MP0005646_abnormal_pituitary_gland0.99958212
40MP0002282_abnormal_trachea_morphology0.98242531
41MP0008877_abnormal_DNA_methylation0.96096025
42MP0001929_abnormal_gametogenesis0.95865564
43MP0010234_abnormal_vibrissa_follicle0.92144925
44MP0003195_calcinosis0.90389859
45MP0005367_renal/urinary_system_phenotyp0.87270148
46MP0000516_abnormal_urinary_system0.87270148
47MP0000749_muscle_degeneration0.84097866
48MP0002877_abnormal_melanocyte_morpholog0.82362344
49MP0006072_abnormal_retinal_apoptosis0.79942007
50MP0003698_abnormal_male_reproductive0.77686701
51MP0009780_abnormal_chondrocyte_physiolo0.77631829
52MP0002736_abnormal_nociception_after0.77537471
53MP0000647_abnormal_sebaceous_gland0.77239481
54MP0009697_abnormal_copulation0.76839163
55MP0005379_endocrine/exocrine_gland_phen0.76332021
56MP0005391_vision/eye_phenotype0.72877397
57MP0001984_abnormal_olfaction0.69393835
58MP0002177_abnormal_outer_ear0.68194068
59MP0000631_abnormal_neuroendocrine_gland0.67607446
60MP0003011_delayed_dark_adaptation0.65564287
61MP0001485_abnormal_pinna_reflex0.65181741
62MP0002160_abnormal_reproductive_system0.63510376
63MP0003943_abnormal_hepatobiliary_system0.62662228
64MP0004142_abnormal_muscle_tone0.61186566
65MP0002210_abnormal_sex_determination0.61144994
66MP0004924_abnormal_behavior0.60884479
67MP0005386_behavior/neurological_phenoty0.60884479
68MP0001968_abnormal_touch/_nociception0.60158752
69MP0004084_abnormal_cardiac_muscle0.58123409
70MP0006036_abnormal_mitochondrial_physio0.57293462
71MP0003890_abnormal_embryonic-extraembry0.56724592
72MP0002234_abnormal_pharynx_morphology0.55013911
73MP0005503_abnormal_tendon_morphology0.53174472
74MP0008057_abnormal_DNA_replication0.52786577
75MP0006292_abnormal_olfactory_placode0.52498616
76MP0002163_abnormal_gland_morphology0.51781243
77MP0008932_abnormal_embryonic_tissue0.51462703
78MP0003077_abnormal_cell_cycle0.51392376
79MP0000653_abnormal_sex_gland0.50676557
80MP0008789_abnormal_olfactory_epithelium0.50336077
81MP0001119_abnormal_female_reproductive0.49352625
82MP0002837_dystrophic_cardiac_calcinosis0.48390149
83MP0002161_abnormal_fertility/fecundity0.48046602
84MP0003693_abnormal_embryo_hatching0.47796220
85MP0010678_abnormal_skin_adnexa0.46735799
86MP0003172_abnormal_lysosome_physiology0.46698616
87MP0002876_abnormal_thyroid_physiology0.46211615
88MP0003252_abnormal_bile_duct0.46188475
89MP0009046_muscle_twitch0.44519620
90MP0004215_abnormal_myocardial_fiber0.44246503
91MP0002229_neurodegeneration0.42875496
92MP0001293_anophthalmia0.41029582
93MP0004147_increased_porphyrin_level0.40631656
94MP0002928_abnormal_bile_duct0.40599937
95MP0008007_abnormal_cellular_replicative0.40469277
96MP0005389_reproductive_system_phenotype0.40223830
97MP0005332_abnormal_amino_acid0.38718202
98MP0003699_abnormal_female_reproductive0.37988940
99MP0004885_abnormal_endolymph0.37570486
100MP0005195_abnormal_posterior_eye0.36892218

Predicted human phenotypes

RankGene SetZ-score
1Ocular albinism (HP:0001107)6.66724244
2Aplasia/Hypoplasia of the macula (HP:0008059)6.53674944
3Hypoplasia of the fovea (HP:0007750)6.06082961
4Aplasia/Hypoplasia of the fovea (HP:0008060)6.06082961
5Aplasia/Hypoplasia affecting the retina (HP:0008061)6.03994911
6Iris hypopigmentation (HP:0007730)5.94115357
7Abnormality of the fovea (HP:0000493)5.12215457
8Congenital stationary night blindness (HP:0007642)4.89150678
9Blue irides (HP:0000635)4.62313617
10Decreased central vision (HP:0007663)4.38567647
11Albinism (HP:0001022)4.24724523
12Generalized hypopigmentation (HP:0007513)4.17070562
13Patchy hypopigmentation of hair (HP:0011365)3.97243057
14Hypopigmentation of the fundus (HP:0007894)3.88728153
15White forelock (HP:0002211)3.78076686
16Long clavicles (HP:0000890)3.66643267
17Intestinal atresia (HP:0011100)3.25877395
18Congenital sensorineural hearing impairment (HP:0008527)3.24352672
19Horizontal nystagmus (HP:0000666)3.21895319
20Amblyopia (HP:0000646)3.21381161
21Megalencephaly (HP:0001355)2.99266916
22Adrenal hypoplasia (HP:0000835)2.86670007
23Abnormal auditory evoked potentials (HP:0006958)2.86395158
24Gaze-evoked nystagmus (HP:0000640)2.76520012
25Fibular hypoplasia (HP:0003038)2.68762228
26Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.59024323
27Freckling (HP:0001480)2.56959242
28Astigmatism (HP:0000483)2.55900913
29Supernumerary spleens (HP:0009799)2.54411368
30Hypoplastic ischia (HP:0003175)2.53902231
31Pancreatic fibrosis (HP:0100732)2.47571260
32Generalized hypopigmentation of hair (HP:0011358)2.43454895
33Tubulointerstitial nephritis (HP:0001970)2.38334955
34Cutaneous melanoma (HP:0012056)2.35640602
35Cholecystitis (HP:0001082)2.34777855
36Abnormal gallbladder physiology (HP:0012438)2.34777855
37Pancreatic cysts (HP:0001737)2.33547497
38True hermaphroditism (HP:0010459)2.28605012
39Degeneration of anterior horn cells (HP:0002398)2.21787526
40Abnormality of the anterior horn cell (HP:0006802)2.21787526
41Abnormality of the ischium (HP:0003174)2.15864462
42Abnormality of midbrain morphology (HP:0002418)2.13163253
43Molar tooth sign on MRI (HP:0002419)2.13163253
44Stillbirth (HP:0003826)2.12131448
45Abnormality of glycolysis (HP:0004366)2.11270013
46Abnormality of chromosome stability (HP:0003220)2.10373736
47Aplasia/Hypoplasia of the tibia (HP:0005772)2.08003146
48Median cleft lip (HP:0000161)2.06608693
49Severe visual impairment (HP:0001141)2.05342499
50Methylmalonic acidemia (HP:0002912)2.00332349
51Epidermoid cyst (HP:0200040)1.99214551
52Abnormal lung lobation (HP:0002101)1.99029130
53Tubulointerstitial abnormality (HP:0001969)1.97596062
54Short tibia (HP:0005736)1.97444632
55Type I transferrin isoform profile (HP:0003642)1.96721603
56Aplasia/Hypoplasia of the fibula (HP:0006492)1.95279509
57Gastrointestinal atresia (HP:0002589)1.93808074
58Tubular atrophy (HP:0000092)1.92820726
59Bifid tongue (HP:0010297)1.91623315
60Small hand (HP:0200055)1.91252423
61Abnormality of macular pigmentation (HP:0008002)1.90854259
62Aplasia/Hypoplasia of the uvula (HP:0010293)1.89358848
63Aplasia/Hypoplasia of the tongue (HP:0010295)1.85478274
64Nephronophthisis (HP:0000090)1.82546154
65Hypophosphatemic rickets (HP:0004912)1.82038811
66Photophobia (HP:0000613)1.81753840
67Absent frontal sinuses (HP:0002688)1.80629857
68Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79662668
69Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78224997
70Abnormal protein N-linked glycosylation (HP:0012347)1.78224997
71Abnormal protein glycosylation (HP:0012346)1.78224997
72Abnormal glycosylation (HP:0012345)1.78224997
73Hematochezia (HP:0002573)1.76598582
74Reduced antithrombin III activity (HP:0001976)1.76486965
75Bilateral sensorineural hearing impairment (HP:0008619)1.74266385
76Heterochromia iridis (HP:0001100)1.70876391
77Sloping forehead (HP:0000340)1.70675173
78Small intestinal stenosis (HP:0012848)1.70153709
79Duodenal stenosis (HP:0100867)1.70153709
80Abnormality of the renal medulla (HP:0100957)1.68746400
81Popliteal pterygium (HP:0009756)1.68052375
82Progressive inability to walk (HP:0002505)1.67003450
83Volvulus (HP:0002580)1.66906050
84Increased serum pyruvate (HP:0003542)1.66815384
85Nephroblastoma (Wilms tumor) (HP:0002667)1.66484551
86Abnormality of the ileum (HP:0001549)1.66240896
87Medial flaring of the eyebrow (HP:0010747)1.65798823
88Short 1st metacarpal (HP:0010034)1.65417649
89Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.65417649
90Embryonal renal neoplasm (HP:0011794)1.65038029
91Meckel diverticulum (HP:0002245)1.64586246
92Abnormality of the left ventricular outflow tract (HP:0011103)1.64211725
93Subaortic stenosis (HP:0001682)1.64211725
94Attenuation of retinal blood vessels (HP:0007843)1.64162549
95Abnormality of vitamin B metabolism (HP:0004340)1.62717467
96Congenital hepatic fibrosis (HP:0002612)1.62146379
97Methylmalonic aciduria (HP:0012120)1.61290049
98Abnormality of sulfur amino acid metabolism (HP:0004339)1.59077337
99Hamartoma of the eye (HP:0010568)1.58705265
100Cystic liver disease (HP:0006706)1.58645136

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.00821387
2BMPR1B3.36315372
3PLK22.86134143
4TRIM282.69201558
5MST42.66934240
6ACVR1B2.55870339
7MAP4K22.48605620
8WEE12.48068688
9WNK32.31349341
10PLK42.27968977
11PDK22.20686663
12PLK32.16003191
13EIF2AK32.09867036
14ERBB32.07607243
15EIF2AK11.97003372
16NUAK11.84042544
17MKNK21.83197496
18MARK31.80987925
19STK241.51762304
20BCR1.49938419
21FER1.46717397
22PAK31.31271837
23BMPR21.30476432
24PNCK1.30269621
25FGFR21.29832386
26STK31.29474710
27STK38L1.18124493
28CSNK1G11.17717767
29ADRBK21.12085592
30ZAK1.11971083
31BUB11.05489507
32PTK2B1.04533250
33LIMK11.03678145
34PRKCH1.02489590
35PLK11.01482525
36MAPK131.01125459
37TNIK1.00802049
38MST1R0.99638815
39CSNK1G20.99141564
40CCNB10.96043774
41INSRR0.95641999
42TTK0.95392631
43MKNK10.90837880
44NEK60.89267616
45CSNK1G30.84674856
46NLK0.84274914
47PBK0.83252193
48BRSK20.79686955
49VRK10.79452996
50MUSK0.77452577
51CSNK1A1L0.73697198
52GSK3A0.73391890
53TGFBR10.69825516
54STK100.67208598
55KSR10.66253983
56MET0.65297837
57MAP3K120.64849587
58MAP3K40.63757266
59BRSK10.62713673
60IRAK20.60505841
61ILK0.59904332
62MINK10.59322777
63PRKCE0.58732180
64IRAK10.58655297
65PINK10.58221908
66SIK30.57911033
67BRD40.56894955
68ATM0.55921217
69CDK30.53430808
70CAMK2A0.52691379
71CSNK1D0.49845693
72GRK50.49804588
73STK390.48101759
74ADRBK10.47820596
75LATS10.47686764
76TNK20.47259833
77FGFR30.45365300
78MELK0.45004463
79RAF10.44926998
80PRKAA20.44725718
81PRKCI0.42868933
82BCKDK0.42143416
83TAF10.41153339
84PRKCG0.40654571
85GRK10.40120756
86ATR0.39724190
87CAMK2D0.39128146
88SRPK10.38712397
89EGFR0.38626769
90PKN10.37070298
91FGR0.36353835
92MAP3K30.35012385
93ARAF0.34761450
94PIK3CG0.33143585
95DYRK30.32368801
96ROCK10.31683767
97STK380.31583218
98DMPK0.30887812
99CDK90.30295134
100NEK10.29739953

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.86395715
2Protein export_Homo sapiens_hsa030603.75270142
3Non-homologous end-joining_Homo sapiens_hsa034503.55108542
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.22739439
5Sulfur metabolism_Homo sapiens_hsa009203.06167988
6Proteasome_Homo sapiens_hsa030502.60330372
7Basal transcription factors_Homo sapiens_hsa030222.51905029
8Homologous recombination_Homo sapiens_hsa034402.50176884
9Propanoate metabolism_Homo sapiens_hsa006402.44417120
10Fanconi anemia pathway_Homo sapiens_hsa034602.28080013
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.24212091
12Butanoate metabolism_Homo sapiens_hsa006502.04972515
13Nitrogen metabolism_Homo sapiens_hsa009101.76888741
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.75974863
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.68041922
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.60736751
17RNA degradation_Homo sapiens_hsa030181.60677964
18Selenocompound metabolism_Homo sapiens_hsa004501.57933675
19Oxidative phosphorylation_Homo sapiens_hsa001901.56664973
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.54167908
21Mismatch repair_Homo sapiens_hsa034301.52686043
22Glutathione metabolism_Homo sapiens_hsa004801.47315576
23Collecting duct acid secretion_Homo sapiens_hsa049661.47016141
24Caffeine metabolism_Homo sapiens_hsa002321.38533817
25Tyrosine metabolism_Homo sapiens_hsa003501.38278325
26Parkinsons disease_Homo sapiens_hsa050121.37605570
27RNA polymerase_Homo sapiens_hsa030201.36760887
28Cell cycle_Homo sapiens_hsa041101.34599421
29Folate biosynthesis_Homo sapiens_hsa007901.32835964
30Oocyte meiosis_Homo sapiens_hsa041141.32236564
31RNA transport_Homo sapiens_hsa030131.31549962
32Steroid biosynthesis_Homo sapiens_hsa001001.31125193
33Phototransduction_Homo sapiens_hsa047441.24434846
34Olfactory transduction_Homo sapiens_hsa047401.23921577
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21267736
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18260722
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17000922
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09825591
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07559977
40Sphingolipid metabolism_Homo sapiens_hsa006001.07079669
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06992118
42p53 signaling pathway_Homo sapiens_hsa041151.01592360
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99283605
44Fatty acid elongation_Homo sapiens_hsa000620.95673649
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93107978
46ABC transporters_Homo sapiens_hsa020100.90660544
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.89885000
48Peroxisome_Homo sapiens_hsa041460.89114601
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87886399
50Circadian rhythm_Homo sapiens_hsa047100.86451130
51Huntingtons disease_Homo sapiens_hsa050160.85194248
52Fatty acid metabolism_Homo sapiens_hsa012120.84659920
53Chemical carcinogenesis_Homo sapiens_hsa052040.83847835
54Tryptophan metabolism_Homo sapiens_hsa003800.81915241
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80812016
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79965459
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78073050
58Fatty acid biosynthesis_Homo sapiens_hsa000610.77712790
59Nucleotide excision repair_Homo sapiens_hsa034200.76843691
60Metabolic pathways_Homo sapiens_hsa011000.71339774
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.67454950
62Taste transduction_Homo sapiens_hsa047420.66343345
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64773994
64Pyruvate metabolism_Homo sapiens_hsa006200.64172317
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64006310
66Melanoma_Homo sapiens_hsa052180.63231855
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60369063
68Fatty acid degradation_Homo sapiens_hsa000710.59688216
69Alzheimers disease_Homo sapiens_hsa050100.59104775
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58727806
71Tight junction_Homo sapiens_hsa045300.57565254
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57217262
73Purine metabolism_Homo sapiens_hsa002300.56621612
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56253464
75Linoleic acid metabolism_Homo sapiens_hsa005910.54540120
76Inositol phosphate metabolism_Homo sapiens_hsa005620.53858126
77Dorso-ventral axis formation_Homo sapiens_hsa043200.53068993
78Base excision repair_Homo sapiens_hsa034100.52376661
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52095945
80TGF-beta signaling pathway_Homo sapiens_hsa043500.51974521
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.48298880
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.44814247
83Pyrimidine metabolism_Homo sapiens_hsa002400.44731182
84One carbon pool by folate_Homo sapiens_hsa006700.41587736
85Arginine and proline metabolism_Homo sapiens_hsa003300.40333780
86beta-Alanine metabolism_Homo sapiens_hsa004100.39424538
87N-Glycan biosynthesis_Homo sapiens_hsa005100.37372231
88Retinol metabolism_Homo sapiens_hsa008300.36902726
89Rheumatoid arthritis_Homo sapiens_hsa053230.35648083
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.29942655
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27163543
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26862889
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25059805
94Melanogenesis_Homo sapiens_hsa049160.24319998
95Starch and sucrose metabolism_Homo sapiens_hsa005000.22976123
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22241691
97Ether lipid metabolism_Homo sapiens_hsa005650.22071666
98Regulation of autophagy_Homo sapiens_hsa041400.20411067
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20336812
100Glycerolipid metabolism_Homo sapiens_hsa005610.19843717

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