C4ORF17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of light stimulus involved in sensory perception (GO:0050962)5.92512610
2detection of light stimulus involved in visual perception (GO:0050908)5.92512610
3tachykinin receptor signaling pathway (GO:0007217)4.60207661
4negative regulation of cytosolic calcium ion concentration (GO:0051481)4.53550388
5indolalkylamine metabolic process (GO:0006586)4.50589133
6establishment of protein localization to Golgi (GO:0072600)4.49462769
7behavioral response to nicotine (GO:0035095)4.31305600
8piRNA metabolic process (GO:0034587)4.18578712
9multicellular organism reproduction (GO:0032504)4.11577376
10fucose catabolic process (GO:0019317)4.11211267
11L-fucose metabolic process (GO:0042354)4.11211267
12L-fucose catabolic process (GO:0042355)4.11211267
13tryptophan catabolic process (GO:0006569)4.10408710
14indole-containing compound catabolic process (GO:0042436)4.10408710
15indolalkylamine catabolic process (GO:0046218)4.10408710
16protein-chromophore linkage (GO:0018298)4.08522556
17cellular ketone body metabolic process (GO:0046950)4.01226653
18photoreceptor cell maintenance (GO:0045494)4.00067943
19detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.97799075
20neural tube formation (GO:0001841)3.90648931
21protein targeting to Golgi (GO:0000042)3.83650028
22behavioral response to ethanol (GO:0048149)3.77378129
23cilium or flagellum-dependent cell motility (GO:0001539)3.76294649
24DNA methylation involved in gamete generation (GO:0043046)3.72919400
25retrograde transport, vesicle recycling within Golgi (GO:0000301)3.61685886
26tryptophan metabolic process (GO:0006568)3.61132359
27rhodopsin mediated signaling pathway (GO:0016056)3.54961295
28ketone body metabolic process (GO:1902224)3.47406087
29sphingoid metabolic process (GO:0046519)3.44181225
30membrane depolarization during action potential (GO:0086010)3.44040350
31signal peptide processing (GO:0006465)3.40430005
32response to pheromone (GO:0019236)3.38732033
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.37961790
34axoneme assembly (GO:0035082)3.34412538
35kynurenine metabolic process (GO:0070189)3.27207046
36regulation of acrosome reaction (GO:0060046)3.26878991
37sperm motility (GO:0030317)3.22437639
38DNA integration (GO:0015074)3.19160034
39C4-dicarboxylate transport (GO:0015740)3.14918128
40central nervous system neuron axonogenesis (GO:0021955)3.14804878
41retinal cone cell development (GO:0046549)3.12094342
42regulation of rhodopsin mediated signaling pathway (GO:0022400)3.11181593
43cell wall macromolecule catabolic process (GO:0016998)3.09552373
44central nervous system projection neuron axonogenesis (GO:0021952)3.09180569
45acrosome reaction (GO:0007340)3.07064349
46epithelial cilium movement (GO:0003351)3.06910382
47protein prenylation (GO:0018342)3.05372556
48prenylation (GO:0097354)3.05372556
49indole-containing compound metabolic process (GO:0042430)3.04788253
50reflex (GO:0060004)3.01813406
51protein localization to Golgi apparatus (GO:0034067)3.00090300
52negative regulation of cAMP-mediated signaling (GO:0043951)2.98784208
53amine catabolic process (GO:0009310)2.97547340
54cellular biogenic amine catabolic process (GO:0042402)2.97547340
55left/right axis specification (GO:0070986)2.97389222
56negative regulation of mast cell activation (GO:0033004)2.96614800
57DNA deamination (GO:0045006)2.95916730
58calcium ion import (GO:0070509)2.95536213
59cell wall macromolecule metabolic process (GO:0044036)2.91837469
60NAD biosynthetic process (GO:0009435)2.91306230
61cellular response to sterol (GO:0036315)2.90464264
62regulation of cilium movement (GO:0003352)2.88959473
63cilium organization (GO:0044782)2.84102782
64phasic smooth muscle contraction (GO:0014821)2.83200831
65protein K11-linked deubiquitination (GO:0035871)2.80683568
66dopamine transport (GO:0015872)2.78708421
67sphingosine metabolic process (GO:0006670)2.77829041
68cilium assembly (GO:0042384)2.77635981
69cAMP catabolic process (GO:0006198)2.74323495
70regulation of hippo signaling (GO:0035330)2.70812162
71nonmotile primary cilium assembly (GO:0035058)2.70637357
72cilium movement (GO:0003341)2.69885428
73cyclic nucleotide catabolic process (GO:0009214)2.68418811
74proline transport (GO:0015824)2.68007618
75neuronal action potential propagation (GO:0019227)2.66570090
76thyroid hormone metabolic process (GO:0042403)2.65571933
77G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.65065023
78cilium morphogenesis (GO:0060271)2.61840901
79primary amino compound metabolic process (GO:1901160)2.61499057
80aromatic amino acid family catabolic process (GO:0009074)2.59742802
81opioid receptor signaling pathway (GO:0038003)2.58648147
82phosphatidylinositol acyl-chain remodeling (GO:0036149)2.58578159
83benzene-containing compound metabolic process (GO:0042537)2.58227856
84centriole replication (GO:0007099)2.55940124
85protein localization to cilium (GO:0061512)2.54546369
86regulation of gonadotropin secretion (GO:0032276)2.53779068
87positive regulation of developmental pigmentation (GO:0048087)2.53625758
88negative regulation of calcium ion transport into cytosol (GO:0010523)2.52757609
89reciprocal DNA recombination (GO:0035825)2.52566279
90reciprocal meiotic recombination (GO:0007131)2.52566279
91visual perception (GO:0007601)2.52510683
92regulation of meiosis I (GO:0060631)2.52001465
93sensory perception of light stimulus (GO:0050953)2.51760055
94thrombin receptor signaling pathway (GO:0070493)2.50936058
95regulation of collateral sprouting (GO:0048670)2.50537272
96single strand break repair (GO:0000012)2.50447074
97histone H3-K4 trimethylation (GO:0080182)2.46989691
98double-strand break repair via homologous recombination (GO:0000724)2.44756816
99protein K63-linked deubiquitination (GO:0070536)2.44238382
100regulation of telomere maintenance (GO:0032204)2.44087180

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.40222421
2GBX2_23144817_ChIP-Seq_PC3_Human3.11584305
3VDR_22108803_ChIP-Seq_LS180_Human2.95716638
4IGF1R_20145208_ChIP-Seq_DFB_Human2.59287836
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.57051550
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.55179745
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.51850131
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.50965049
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.50932238
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42908063
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.39861299
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.18539398
13EZH2_22144423_ChIP-Seq_EOC_Human2.14315715
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.12797824
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.06146591
16P300_19829295_ChIP-Seq_ESCs_Human2.04276105
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02553595
18SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.01094877
19BCAT_22108803_ChIP-Seq_LS180_Human1.97634387
20ER_23166858_ChIP-Seq_MCF-7_Human1.95981289
21FUS_26573619_Chip-Seq_HEK293_Human1.94558267
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89387663
23STAT3_23295773_ChIP-Seq_U87_Human1.87030576
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.85127319
25TAF15_26573619_Chip-Seq_HEK293_Human1.84941307
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.84868143
27SMAD4_21799915_ChIP-Seq_A2780_Human1.74904372
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.72938094
29CBP_20019798_ChIP-Seq_JUKART_Human1.72938094
30POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.71593612
31TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71593612
32* TCF4_23295773_ChIP-Seq_U87_Human1.67213658
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.65746180
34AR_21572438_ChIP-Seq_LNCaP_Human1.64103904
35NR3C1_21868756_ChIP-Seq_MCF10A_Human1.64034920
36* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63720299
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57846610
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.55752904
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55559859
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50804750
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50351586
42TCF4_22108803_ChIP-Seq_LS180_Human1.50343431
43EWS_26573619_Chip-Seq_HEK293_Human1.50132106
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45869567
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.42550032
46NANOG_19829295_ChIP-Seq_ESCs_Human1.42356589
47SOX2_19829295_ChIP-Seq_ESCs_Human1.42356589
48AR_25329375_ChIP-Seq_VCAP_Human1.41463077
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38743792
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.37420307
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37011720
52KLF5_20875108_ChIP-Seq_MESCs_Mouse1.36721662
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.35752478
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.35022473
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34401016
56TP53_22573176_ChIP-Seq_HFKS_Human1.33436691
57CDX2_22108803_ChIP-Seq_LS180_Human1.29273239
58RUNX2_22187159_ChIP-Seq_PCA_Human1.28725287
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28088168
60PRDM14_20953172_ChIP-Seq_ESCs_Human1.26857300
61FLI1_21867929_ChIP-Seq_TH2_Mouse1.26031666
62CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24780296
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23951333
64FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23177434
65TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20207426
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19875439
67CRX_20693478_ChIP-Seq_RETINA_Mouse1.19279336
68DROSHA_22980978_ChIP-Seq_HELA_Human1.17670199
69SMAD4_21741376_ChIP-Seq_EPCs_Human1.16868070
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16758318
71AHR_22903824_ChIP-Seq_MCF-7_Human1.15705413
72EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15035970
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.14690776
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14655261
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12796767
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12106121
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11845567
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11654962
79ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11398912
80IRF1_19129219_ChIP-ChIP_H3396_Human1.11259401
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.10743769
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.09458744
83RXR_22108803_ChIP-Seq_LS180_Human1.08265756
84GATA3_21878914_ChIP-Seq_MCF-7_Human1.07461168
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06254115
86OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05960786
87TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05828700
88KDM2B_26808549_Chip-Seq_REH_Human1.05747569
89P53_22387025_ChIP-Seq_ESCs_Mouse1.05534235
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02535041
91SMAD_19615063_ChIP-ChIP_OVARY_Human1.02145604
92HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.01755007
93NCOR_22424771_ChIP-Seq_293T_Human1.01686023
94PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01443453
95SOX2_21211035_ChIP-Seq_LN229_Gbm1.00950960
96AR_20517297_ChIP-Seq_VCAP_Human0.99797494
97FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99662867
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99390442
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99056469
100CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99045737

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.11672450
2MP0000372_irregular_coat_pigmentation3.36784658
3MP0002102_abnormal_ear_morphology3.25386920
4MP0005551_abnormal_eye_electrophysiolog3.20000697
5MP0008877_abnormal_DNA_methylation3.16497629
6MP0003950_abnormal_plasma_membrane2.90276255
7MP0002638_abnormal_pupillary_reflex2.83945209
8MP0003195_calcinosis2.81667135
9MP0003136_yellow_coat_color2.42960813
10MP0005670_abnormal_white_adipose2.40060986
11MP0008057_abnormal_DNA_replication2.30908706
12MP0001501_abnormal_sleep_pattern2.26605391
13MP0002876_abnormal_thyroid_physiology2.14387941
14MP0001486_abnormal_startle_reflex2.04078059
15MP0002837_dystrophic_cardiac_calcinosis2.03028090
16MP0003646_muscle_fatigue2.01818156
17MP0001968_abnormal_touch/_nociception2.00192420
18MP0004147_increased_porphyrin_level1.99760145
19MP0005253_abnormal_eye_physiology1.88895215
20MP0001984_abnormal_olfaction1.86448033
21MP0009046_muscle_twitch1.82451559
22MP0005174_abnormal_tail_pigmentation1.81831402
23MP0001986_abnormal_taste_sensitivity1.75241159
24MP0003045_fibrosis1.73905169
25MP0009745_abnormal_behavioral_response1.72631983
26MP0001485_abnormal_pinna_reflex1.72078579
27MP0005645_abnormal_hypothalamus_physiol1.72002561
28MP0005646_abnormal_pituitary_gland1.70672993
29MP0001764_abnormal_homeostasis1.70574748
30MP0008872_abnormal_physiological_respon1.69820874
31MP0003718_maternal_effect1.67853704
32MP0005410_abnormal_fertilization1.61905519
33MP0004142_abnormal_muscle_tone1.57427488
34MP0006276_abnormal_autonomic_nervous1.52860029
35MP0008875_abnormal_xenobiotic_pharmacok1.52032372
36MP0002653_abnormal_ependyma_morphology1.50165823
37MP0005360_urolithiasis1.46212737
38MP0004742_abnormal_vestibular_system1.44155457
39MP0003878_abnormal_ear_physiology1.42571565
40MP0005377_hearing/vestibular/ear_phenot1.42571565
41MP0000427_abnormal_hair_cycle1.38204387
42MP0002090_abnormal_vision1.36213162
43MP0005187_abnormal_penis_morphology1.35523701
44MP0003787_abnormal_imprinting1.34592021
45MP0003698_abnormal_male_reproductive1.33283418
46MP0002736_abnormal_nociception_after1.33139703
47MP0002735_abnormal_chemical_nociception1.30908030
48MP0005171_absent_coat_pigmentation1.24731237
49MP0004043_abnormal_pH_regulation1.23366185
50MP0002733_abnormal_thermal_nociception1.23098815
51MP0005395_other_phenotype1.21483664
52MP0002272_abnormal_nervous_system1.19311806
53MP0002168_other_aberrant_phenotype1.19015667
54MP0001929_abnormal_gametogenesis1.16059962
55MP0001529_abnormal_vocalization1.15074269
56MP0000383_abnormal_hair_follicle1.15003225
57MP0002928_abnormal_bile_duct1.12941745
58MP0003252_abnormal_bile_duct1.12047504
59MP0000538_abnormal_urinary_bladder1.11540584
60MP0003880_abnormal_central_pattern1.10329860
61MP0004885_abnormal_endolymph1.08942910
62MP0002822_catalepsy1.08263426
63MP0001970_abnormal_pain_threshold1.08099506
64MP0002572_abnormal_emotion/affect_behav1.07422036
65MP0005310_abnormal_salivary_gland1.05764906
66MP0001905_abnormal_dopamine_level1.03080302
67MP0001502_abnormal_circadian_rhythm1.02341270
68MP0002557_abnormal_social/conspecific_i1.01982682
69MP0002160_abnormal_reproductive_system0.98910307
70MP0003633_abnormal_nervous_system0.97897889
71MP0005389_reproductive_system_phenotype0.97194704
72MP0006292_abnormal_olfactory_placode0.96149123
73MP0002064_seizures0.95691644
74MP0006072_abnormal_retinal_apoptosis0.93864270
75MP0000371_diluted_coat_color0.93777775
76MP0004924_abnormal_behavior0.93636900
77MP0005386_behavior/neurological_phenoty0.93636900
78MP0002938_white_spotting0.92202687
79MP0002229_neurodegeneration0.92111210
80MP0005195_abnormal_posterior_eye0.92089996
81MP0002095_abnormal_skin_pigmentation0.88023165
82MP0000230_abnormal_systemic_arterial0.86944378
83MP0004215_abnormal_myocardial_fiber0.85288095
84MP0008058_abnormal_DNA_repair0.84539574
85MP0002067_abnormal_sensory_capabilities0.84028311
86MP0005075_abnormal_melanosome_morpholog0.82221190
87MP0005266_abnormal_metabolism0.80504659
88MP0003635_abnormal_synaptic_transmissio0.79330359
89MP0001963_abnormal_hearing_physiology0.77308063
90MP0002210_abnormal_sex_determination0.75902088
91MP0002752_abnormal_somatic_nervous0.75678236
92MP0003943_abnormal_hepatobiliary_system0.75468558
93MP0003631_nervous_system_phenotype0.74470563
94MP0000653_abnormal_sex_gland0.74118764
95MP0005376_homeostasis/metabolism_phenot0.74107065
96MP0002693_abnormal_pancreas_physiology0.73641318
97MP0005397_hematopoietic_system_phenotyp0.72556294
98MP0001545_abnormal_hematopoietic_system0.72556294
99MP0005167_abnormal_blood-brain_barrier0.71356969
100MP0008775_abnormal_heart_ventricle0.70916359

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.04594583
2Pancreatic cysts (HP:0001737)4.28829678
3Chronic hepatic failure (HP:0100626)4.28202765
4Abnormal rod and cone electroretinograms (HP:0008323)4.15111158
5Abnormality of macular pigmentation (HP:0008002)3.86413767
6Abnormality of midbrain morphology (HP:0002418)3.71609065
7Molar tooth sign on MRI (HP:0002419)3.71609065
8True hermaphroditism (HP:0010459)3.65647021
9Central scotoma (HP:0000603)3.61461484
10Pancreatic fibrosis (HP:0100732)3.61231503
11Abnormality of the renal cortex (HP:0011035)3.55910423
12Attenuation of retinal blood vessels (HP:0007843)3.32244939
13Severe visual impairment (HP:0001141)3.27057369
14Gaze-evoked nystagmus (HP:0000640)3.21907520
15Abnormality of the renal medulla (HP:0100957)3.11217263
16Nephronophthisis (HP:0000090)3.06263276
17Cystic liver disease (HP:0006706)3.01030359
18Focal seizures (HP:0007359)2.98847153
19Focal motor seizures (HP:0011153)2.97484027
20Medial flaring of the eyebrow (HP:0010747)2.95145193
21Genetic anticipation (HP:0003743)2.93254174
22Absent rod-and cone-mediated responses on ERG (HP:0007688)2.91465866
23Aplasia/Hypoplasia of the fovea (HP:0008060)2.82397695
24Hypoplasia of the fovea (HP:0007750)2.82397695
25Progressive cerebellar ataxia (HP:0002073)2.80461861
26Volvulus (HP:0002580)2.77435014
27Tubular atrophy (HP:0000092)2.65167144
28Pendular nystagmus (HP:0012043)2.57653586
29Bony spicule pigmentary retinopathy (HP:0007737)2.56231135
30Optic nerve hypoplasia (HP:0000609)2.54759670
31Sclerocornea (HP:0000647)2.53005671
32Hyperventilation (HP:0002883)2.51452271
33Decreased central vision (HP:0007663)2.51290496
34Renal cortical cysts (HP:0000803)2.49273435
35Abnormality of the labia minora (HP:0012880)2.49137533
36Scotoma (HP:0000575)2.48181083
37Congenital primary aphakia (HP:0007707)2.47686590
38Gait imbalance (HP:0002141)2.46717519
39Absent speech (HP:0001344)2.45258753
40Abnormality of the fovea (HP:0000493)2.44736161
41Bile duct proliferation (HP:0001408)2.42768264
42Abnormal biliary tract physiology (HP:0012439)2.42768264
43Aplasia/Hypoplasia of the macula (HP:0008059)2.41651801
44Aplasia/Hypoplasia of the tibia (HP:0005772)2.38223851
45Constricted visual fields (HP:0001133)2.37257629
46Febrile seizures (HP:0002373)2.35331405
47Tubulointerstitial nephritis (HP:0001970)2.32357067
48Abolished electroretinogram (ERG) (HP:0000550)2.28129096
49Dialeptic seizures (HP:0011146)2.27481682
50Increased corneal curvature (HP:0100692)2.22723060
51Keratoconus (HP:0000563)2.22723060
52Aplasia/Hypoplasia affecting the retina (HP:0008061)2.21126064
53Abnormal drinking behavior (HP:0030082)2.20969112
54Polydipsia (HP:0001959)2.20969112
55Dynein arm defect of respiratory motile cilia (HP:0012255)2.20505816
56Absent/shortened dynein arms (HP:0200106)2.20505816
57Albinism (HP:0001022)2.18781527
58Supernumerary spleens (HP:0009799)2.17976895
59Hypothermia (HP:0002045)2.14070420
60Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.11496229
61Aplasia/Hypoplasia of the tongue (HP:0010295)2.10804195
62Stomach cancer (HP:0012126)2.10378910
63Nephrogenic diabetes insipidus (HP:0009806)2.10342375
64Cerebellar dysplasia (HP:0007033)2.09274874
65Occipital encephalocele (HP:0002085)2.08839828
66Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.08838654
67Poor coordination (HP:0002370)2.06362109
68Thyroid-stimulating hormone excess (HP:0002925)2.03618594
69Congenital hepatic fibrosis (HP:0002612)2.02183131
70Broad-based gait (HP:0002136)2.01059682
71Anencephaly (HP:0002323)2.00373037
72Chromsome breakage (HP:0040012)1.99580881
73Tubulointerstitial abnormality (HP:0001969)1.96263986
74Genital tract atresia (HP:0001827)1.94034685
75Large for gestational age (HP:0001520)1.93778430
76Vaginal atresia (HP:0000148)1.93727277
77Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.92224039
78Generalized hypopigmentation of hair (HP:0011358)1.91133704
79Furrowed tongue (HP:0000221)1.90651203
80Inability to walk (HP:0002540)1.88129053
81Retinitis pigmentosa (HP:0000510)1.85516303
82Abnormal ciliary motility (HP:0012262)1.84150666
83Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.83312403
84Protruding tongue (HP:0010808)1.82961710
85Macular degeneration (HP:0000608)1.82245254
86Widely spaced teeth (HP:0000687)1.81537168
87Polyuria (HP:0000103)1.81299723
88Decreased circulating renin level (HP:0003351)1.81270727
89Astigmatism (HP:0000483)1.80452498
90Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79741101
91Highly arched eyebrow (HP:0002553)1.79269791
92Bilateral sensorineural hearing impairment (HP:0008619)1.77551946
93Type II lissencephaly (HP:0007260)1.77331487
94Male pseudohermaphroditism (HP:0000037)1.76937148
95Intestinal atresia (HP:0011100)1.76736092
96Amelogenesis imperfecta (HP:0000705)1.76354607
97Hypoplastic labia majora (HP:0000059)1.74792515
98Partial agenesis of the corpus callosum (HP:0001338)1.74710107
99Chromosomal breakage induced by crosslinking agents (HP:0003221)1.73330989
100Abnormal respiratory epithelium morphology (HP:0012253)1.72205114

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.43887694
2ADRBK23.45773849
3TAOK32.80848945
4MAP4K22.34088580
5PINK12.20315081
6GRK12.09021659
7STK38L2.00938195
8TNK21.99013171
9BMPR1B1.97039236
10ZAK1.95511357
11WNK31.91367445
12NUAK11.89829429
13MAPK131.84222190
14TEC1.59582163
15ACVR1B1.58607275
16PAK31.53824989
17CASK1.51807802
18GRK71.42861484
19PIK3CG1.41974982
20INSRR1.40139530
21LATS11.38634511
22PTK2B1.31061973
23TNIK1.27991674
24OXSR11.27447144
25STK391.20903051
26ADRBK11.18489977
27PRKCE1.14253183
28PIK3CA1.11637539
29PLK21.08182825
30MAP3K41.06996198
31ITK1.06844454
32EIF2AK31.04747550
33TXK1.02661939
34MARK31.00378600
35MAP3K70.99151102
36CAMK1G0.96228738
37AKT30.91607291
38NLK0.88403766
39CDK30.87610352
40BRD40.83633225
41STK160.83250415
42KIT0.80832593
43BRSK20.80481411
44FER0.78296939
45PRKCG0.76747438
46MKNK20.75256739
47NTRK30.74716417
48FGFR20.74183084
49PNCK0.74070312
50PKN10.73270548
51CAMK10.71194806
52PRKAA20.68688158
53SIK20.68502089
54PRKCQ0.67256102
55WNK40.63690171
56CAMK1D0.63215351
57STK380.61893771
58MARK10.60870561
59TRIM280.58241280
60DAPK20.57483537
61CSNK1A1L0.57028010
62STK30.56749932
63BTK0.55105557
64BCKDK0.53582503
65EPHA40.53191104
66PRKD30.50087491
67PRKAA10.49980657
68ERBB30.49118542
69TLK10.48573249
70CAMK2A0.48339791
71CAMK40.47464573
72TRPM70.46874746
73IKBKB0.46276223
74GRK50.44659406
75PRKACA0.44329392
76WEE10.43597414
77ERBB20.43264216
78PDK20.42039094
79SIK30.41814053
80KDR0.40435818
81ATR0.40429982
82VRK10.40389766
83RPS6KA50.39616906
84PRKCB0.37620662
85PRKG10.37295884
86CSNK1D0.36891529
87PRKACB0.36598602
88MKNK10.36495043
89MAP2K60.35938011
90NME10.35038482
91TGFBR20.34242235
92IRAK10.33810436
93SYK0.33321532
94PLK40.32777439
95CDC70.32705325
96MELK0.32404462
97CSNK1A10.32015390
98MAPK110.31855497
99SGK20.30054749
100LYN0.29391832

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.30840793
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.14451878
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.98534587
4Linoleic acid metabolism_Homo sapiens_hsa005912.74629978
5Butanoate metabolism_Homo sapiens_hsa006502.68629738
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.65378333
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.50321928
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.15897998
9Nitrogen metabolism_Homo sapiens_hsa009102.09303178
10Olfactory transduction_Homo sapiens_hsa047402.09134693
11Tryptophan metabolism_Homo sapiens_hsa003802.07600904
12ABC transporters_Homo sapiens_hsa020102.00641540
13Taste transduction_Homo sapiens_hsa047421.94655023
14Caffeine metabolism_Homo sapiens_hsa002321.90902882
15Nicotine addiction_Homo sapiens_hsa050331.85147909
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.84223022
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80853925
18Ether lipid metabolism_Homo sapiens_hsa005651.72596507
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.71154654
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.70673659
21Morphine addiction_Homo sapiens_hsa050321.68735198
22Homologous recombination_Homo sapiens_hsa034401.65201518
23Fatty acid biosynthesis_Homo sapiens_hsa000611.61505259
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.60630737
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.57836562
26Fanconi anemia pathway_Homo sapiens_hsa034601.52286325
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51229542
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.50206071
29Serotonergic synapse_Homo sapiens_hsa047261.46080823
30Dorso-ventral axis formation_Homo sapiens_hsa043201.45978245
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33748146
32Chemical carcinogenesis_Homo sapiens_hsa052041.30679999
33Glycerolipid metabolism_Homo sapiens_hsa005611.29256876
34Retinol metabolism_Homo sapiens_hsa008301.28054940
35Ovarian steroidogenesis_Homo sapiens_hsa049131.27687806
36Propanoate metabolism_Homo sapiens_hsa006401.25927679
37Circadian entrainment_Homo sapiens_hsa047131.22894875
38One carbon pool by folate_Homo sapiens_hsa006701.22818963
39Calcium signaling pathway_Homo sapiens_hsa040201.20174070
40Sphingolipid metabolism_Homo sapiens_hsa006001.18527134
41Selenocompound metabolism_Homo sapiens_hsa004501.12905299
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11003366
43Peroxisome_Homo sapiens_hsa041461.09435832
44Glutamatergic synapse_Homo sapiens_hsa047241.06001349
45GABAergic synapse_Homo sapiens_hsa047271.05347679
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.04230717
47Lysine degradation_Homo sapiens_hsa003101.03142921
48Salivary secretion_Homo sapiens_hsa049701.02972874
49Arachidonic acid metabolism_Homo sapiens_hsa005901.01984345
50Non-homologous end-joining_Homo sapiens_hsa034501.01662897
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00747210
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.95218981
53Histidine metabolism_Homo sapiens_hsa003400.94713793
54Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91441127
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84401758
56beta-Alanine metabolism_Homo sapiens_hsa004100.82088534
57Basal transcription factors_Homo sapiens_hsa030220.80093988
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.79942684
59Insulin secretion_Homo sapiens_hsa049110.78571196
60Fatty acid degradation_Homo sapiens_hsa000710.77325473
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.75160164
62Cholinergic synapse_Homo sapiens_hsa047250.73190790
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72376852
64Renin secretion_Homo sapiens_hsa049240.67875853
65Regulation of autophagy_Homo sapiens_hsa041400.67759304
66RNA polymerase_Homo sapiens_hsa030200.63429631
67Purine metabolism_Homo sapiens_hsa002300.62733951
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62618607
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60886651
70Mineral absorption_Homo sapiens_hsa049780.58295912
71Primary immunodeficiency_Homo sapiens_hsa053400.58284700
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57640157
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57272703
74Circadian rhythm_Homo sapiens_hsa047100.56072699
75Fatty acid metabolism_Homo sapiens_hsa012120.54271478
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54166682
77Oxytocin signaling pathway_Homo sapiens_hsa049210.54138487
78Platelet activation_Homo sapiens_hsa046110.53206017
79cAMP signaling pathway_Homo sapiens_hsa040240.46886930
80Pancreatic secretion_Homo sapiens_hsa049720.45550254
81Metabolic pathways_Homo sapiens_hsa011000.44427046
82Glutathione metabolism_Homo sapiens_hsa004800.43636571
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42956063
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.42470261
85Dopaminergic synapse_Homo sapiens_hsa047280.35588388
86Fat digestion and absorption_Homo sapiens_hsa049750.35223313
87Hedgehog signaling pathway_Homo sapiens_hsa043400.34267807
88PPAR signaling pathway_Homo sapiens_hsa033200.33003719
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32643371
90Long-term depression_Homo sapiens_hsa047300.32081852
91Complement and coagulation cascades_Homo sapiens_hsa046100.31979883
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29266103
93RNA degradation_Homo sapiens_hsa030180.26806222
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.25751626
95Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.25328039
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.22099270
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21960733
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21480935
99Gastric acid secretion_Homo sapiens_hsa049710.20293191
100Huntingtons disease_Homo sapiens_hsa050160.19648914

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