C4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.98346201
2L-phenylalanine catabolic process (GO:0006559)6.98346201
3complement activation, alternative pathway (GO:0006957)6.97790900
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.67039308
5L-phenylalanine metabolic process (GO:0006558)6.67039308
6epoxygenase P450 pathway (GO:0019373)6.20674156
7aromatic amino acid family catabolic process (GO:0009074)6.15043698
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.08292867
9omega-hydroxylase P450 pathway (GO:0097267)5.97878844
10exogenous drug catabolic process (GO:0042738)5.94983249
11alpha-linolenic acid metabolic process (GO:0036109)5.73142174
12* regulation of protein activation cascade (GO:2000257)5.72975357
13glucocorticoid biosynthetic process (GO:0006704)5.53602139
14indole-containing compound catabolic process (GO:0042436)5.53518198
15indolalkylamine catabolic process (GO:0046218)5.53518198
16tryptophan catabolic process (GO:0006569)5.53518198
17peptidyl-glutamic acid carboxylation (GO:0017187)5.52229626
18protein carboxylation (GO:0018214)5.52229626
19bile acid biosynthetic process (GO:0006699)5.47966970
20kynurenine metabolic process (GO:0070189)5.44319223
21* regulation of complement activation (GO:0030449)5.41606430
22urea cycle (GO:0000050)5.39760888
23urea metabolic process (GO:0019627)5.39760888
24negative regulation of fibrinolysis (GO:0051918)5.26154190
25glyoxylate metabolic process (GO:0046487)5.23828910
26tryptophan metabolic process (GO:0006568)5.19791207
27* regulation of apoptotic cell clearance (GO:2000425)5.11153943
28regulation of fibrinolysis (GO:0051917)5.07861967
29high-density lipoprotein particle remodeling (GO:0034375)5.05044038
30sulfur amino acid catabolic process (GO:0000098)4.96153441
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.95013120
32nitrogen cycle metabolic process (GO:0071941)4.94863486
33cysteine metabolic process (GO:0006534)4.81127594
34regulation of plasminogen activation (GO:0010755)4.75310358
35bile acid metabolic process (GO:0008206)4.71464292
36regulation of triglyceride catabolic process (GO:0010896)4.67651636
37reverse cholesterol transport (GO:0043691)4.64548581
38plasma lipoprotein particle clearance (GO:0034381)4.57758205
39serine family amino acid catabolic process (GO:0009071)4.57687543
40regulation of cholesterol esterification (GO:0010872)4.52980318
41phospholipid efflux (GO:0033700)4.48166299
42triglyceride homeostasis (GO:0070328)4.46572023
43acylglycerol homeostasis (GO:0055090)4.46572023
44protein-lipid complex remodeling (GO:0034368)4.46258860
45macromolecular complex remodeling (GO:0034367)4.46258860
46plasma lipoprotein particle remodeling (GO:0034369)4.46258860
47* complement activation (GO:0006956)4.42945418
48aromatic amino acid family metabolic process (GO:0009072)4.42149046
49tyrosine metabolic process (GO:0006570)4.39763839
50homocysteine metabolic process (GO:0050667)4.39638811
51ethanol metabolic process (GO:0006067)4.29826975
52glucocorticoid metabolic process (GO:0008211)4.26050382
53alpha-amino acid catabolic process (GO:1901606)4.25337124
54amino-acid betaine metabolic process (GO:0006577)4.23868627
55drug metabolic process (GO:0017144)4.21264023
56lysine catabolic process (GO:0006554)4.19876795
57lysine metabolic process (GO:0006553)4.19876795
58negative regulation of sterol transport (GO:0032372)4.17792147
59negative regulation of cholesterol transport (GO:0032375)4.17792147
60negative regulation of complement activation (GO:0045916)4.13976828
61positive regulation of fatty acid biosynthetic process (GO:0045723)4.12339908
62* protein activation cascade (GO:0072376)4.12028222
63negative regulation of blood coagulation (GO:0030195)4.08502559
64negative regulation of hemostasis (GO:1900047)4.08502559
65* complement activation, classical pathway (GO:0006958)4.08128193
66ethanol oxidation (GO:0006069)4.06338055
67imidazole-containing compound metabolic process (GO:0052803)4.04780118
68cholesterol efflux (GO:0033344)4.04696445
69coenzyme catabolic process (GO:0009109)4.04640475
70bile acid and bile salt transport (GO:0015721)3.99871023
71glutamate metabolic process (GO:0006536)3.95754337
72fibrinolysis (GO:0042730)3.92744447
73cellular amino acid catabolic process (GO:0009063)3.91227077
74plasma lipoprotein particle assembly (GO:0034377)3.88265005
75low-density lipoprotein particle remodeling (GO:0034374)3.88225581
76cellular ketone body metabolic process (GO:0046950)3.86939091
77indolalkylamine metabolic process (GO:0006586)3.86329283
78positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.84702954
79glycine metabolic process (GO:0006544)3.79599969
80glucuronate metabolic process (GO:0019585)3.79580819
81uronic acid metabolic process (GO:0006063)3.79580819
82cellular modified amino acid catabolic process (GO:0042219)3.79552491
83phospholipid homeostasis (GO:0055091)3.76427174
84amine catabolic process (GO:0009310)3.74053075
85cellular biogenic amine catabolic process (GO:0042402)3.74053075
86positive regulation of lipid catabolic process (GO:0050996)3.74009965
87androgen biosynthetic process (GO:0006702)3.72306635
88regulation of cholesterol homeostasis (GO:2000188)3.72206303
89intestinal cholesterol absorption (GO:0030299)3.71273942
90oxidative demethylation (GO:0070989)3.71029227
91negative regulation of coagulation (GO:0050819)3.70403883
92cellular glucuronidation (GO:0052695)3.69982591
93negative regulation of wound healing (GO:0061045)3.68047704
94dicarboxylic acid biosynthetic process (GO:0043650)3.67366779
95benzene-containing compound metabolic process (GO:0042537)3.65958090
96acetyl-CoA metabolic process (GO:0006084)3.65225536
97protein-lipid complex subunit organization (GO:0071825)3.63031008
98acute-phase response (GO:0006953)3.62206352
99serine family amino acid metabolic process (GO:0009069)3.61580929
100positive regulation of blood coagulation (GO:0030194)3.61027073
101positive regulation of hemostasis (GO:1900048)3.61027073
102arginine metabolic process (GO:0006525)3.60928964
103positive regulation of fatty acid beta-oxidation (GO:0032000)3.60173774
104positive regulation of lipoprotein lipase activity (GO:0051006)3.59873914
105positive regulation of triglyceride lipase activity (GO:0061365)3.59873914
106cholesterol homeostasis (GO:0042632)3.58761609
107cytolysis (GO:0019835)3.56851761
108acute inflammatory response (GO:0002526)3.56828442
109blood coagulation, intrinsic pathway (GO:0007597)3.56528896
110protein-lipid complex assembly (GO:0065005)3.54440550
111regulation of cholesterol biosynthetic process (GO:0045540)3.54218916
112sterol homeostasis (GO:0055092)3.52817397
113negative regulation of lipase activity (GO:0060192)3.51773890
114* opsonization (GO:0008228)3.51159662
115plasma lipoprotein particle organization (GO:0071827)3.50175197
116aldehyde catabolic process (GO:0046185)3.49048752
117negative regulation of protein activation cascade (GO:2000258)3.48398936
118organic acid catabolic process (GO:0016054)3.48277076
119carboxylic acid catabolic process (GO:0046395)3.48277076
120* regulation of acute inflammatory response (GO:0002673)3.47380087
121drug catabolic process (GO:0042737)3.46088257
122very-low-density lipoprotein particle assembly (GO:0034379)3.44908930
123* regulation of humoral immune response (GO:0002920)3.44612452
124cofactor catabolic process (GO:0051187)3.43525800
125regulation of bile acid biosynthetic process (GO:0070857)3.41914773
126lipoprotein metabolic process (GO:0042157)3.40325225
127positive regulation of steroid metabolic process (GO:0045940)3.38597779
128disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.36760206
129killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.36760206
130short-chain fatty acid metabolic process (GO:0046459)3.36015851
131serine family amino acid biosynthetic process (GO:0009070)3.35412149
132positive regulation of coagulation (GO:0050820)3.31831988
133phenylpropanoid metabolic process (GO:0009698)3.30262272
134negative regulation of humoral immune response (GO:0002921)3.29030929
135regulation of cholesterol metabolic process (GO:0090181)3.26415800
136response to mercury ion (GO:0046689)3.25062064
137sterol transport (GO:0015918)3.10812198
138cholesterol transport (GO:0030301)3.10812198

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.74139658
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.67434165
3LXR_22158963_ChIP-Seq_LIVER_Mouse6.09760693
4* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.03280730
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.56819705
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.95626368
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.41852653
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.93095168
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.46029588
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24432554
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.09456185
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.9881203
13CLOCK_20551151_ChIP-Seq_293T_Human1.98871361
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.88573065
15TP63_17297297_ChIP-ChIP_HaCaT_Human1.76041332
16FOXA2_19822575_ChIP-Seq_HepG2_Human1.63388392
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.60860233
18* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.60388847
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51520038
20RARG_19884340_ChIP-ChIP_MEFs_Mouse1.41144241
21HTT_18923047_ChIP-ChIP_STHdh_Human1.37024775
22GATA1_22025678_ChIP-Seq_K562_Human1.31043569
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30042650
24HNF4A_19822575_ChIP-Seq_HepG2_Human1.28964805
25DROSHA_22980978_ChIP-Seq_HELA_Human1.24862685
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19328201
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19048343
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.12946186
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.11534705
30ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08799860
31ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06900403
32BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06601732
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06042710
34CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05167815
35* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.04255679
36ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02213985
37SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99039538
38LXR_22292898_ChIP-Seq_THP-1_Human0.94322861
39SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93875233
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92742318
41SMC4_20622854_ChIP-Seq_HELA_Human0.92722098
42DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92452834
43ESR2_21235772_ChIP-Seq_MCF-7_Human0.91527619
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90226535
45ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87305701
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.85777211
47CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84723743
48ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84206476
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83386002
50SOX9_24532713_ChIP-Seq_HFSC_Mouse0.81617447
51FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78017218
52CTCF_27219007_Chip-Seq_Bcells_Human0.77104852
53GATA4_25053715_ChIP-Seq_YYC3_Human0.74238899
54KDM2B_26808549_Chip-Seq_K562_Human0.73777183
55BP1_19119308_ChIP-ChIP_Hs578T_Human0.72731984
56SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72134518
57SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72089867
58AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.71979572
59NRF2_20460467_ChIP-Seq_MEFs_Mouse0.71485803
60NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.71485803
61EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.70412298
62AUTS2_25519132_ChIP-Seq_293T-REX_Human0.68868968
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.68868351
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.67839022
65* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.67432233
66IRF8_27001747_Chip-Seq_BMDM_Mouse0.67169083
67PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.66947498
68RARA_24833708_ChIP-Seq_LIVER_Mouse0.66912531
69FOXO3_23340844_ChIP-Seq_DLD1_Human0.66776960
70STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.66716099
71GATA1_19941826_ChIP-Seq_K562_Human0.66547609
72TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65454331
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.65346953
74MTF2_20144788_ChIP-Seq_MESCs_Mouse0.65309027
75GATA6_25053715_ChIP-Seq_YYC3_Human0.65032928
76P63_26484246_Chip-Seq_KERATINOCYTES_Human0.64327079
77POU5F1_16518401_ChIP-PET_MESCs_Mouse0.64323030
78SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.64026112
79EGR1_19032775_ChIP-ChIP_M12_Human0.63797090
80RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63141653
81KDM2B_26808549_Chip-Seq_SUP-B15_Human0.62935502
82GATA2_19941826_ChIP-Seq_K562_Human0.62935427
83NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.61985478
84TCF4_18268006_ChIP-ChIP_LS174T_Human0.61926432
85GATA1_19941827_ChIP-Seq_MEL_Mouse0.61531760
86RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.61506933
87ELK3_25401928_ChIP-Seq_HUVEC_Human0.61436332
88PPAR_26484153_Chip-Seq_NCI-H1993_Human0.61125236
89RUNX1_27514584_Chip-Seq_MCF-7_Human0.61072770
90EP300_21415370_ChIP-Seq_HL-1_Mouse0.61052849
91ESR1_21235772_ChIP-Seq_MCF-7_Human0.60323127
92SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.60097133
93ZNF263_19887448_ChIP-Seq_K562_Human0.59991399
94TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.59294297
95NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.58429574
96PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.58177571
97ERG_21242973_ChIP-ChIP_JURKAT_Human0.57761005
98PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.57681728
99CEBPB_22108803_ChIP-Seq_LS180_Human0.56565174
100RARB_24833708_ChIP-Seq_LIVER_Mouse0.55106559
101BRD4_27068464_Chip-Seq_AML-cells_Mouse0.54692520
102RACK7_27058665_Chip-Seq_MCF-7_Human0.53931240
103PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.53568886
104BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.53540790
105GATA2_21666600_ChIP-Seq_HMVEC_Human0.53491651
106IRF8_21731497_ChIP-ChIP_J774_Mouse0.53299300
107MYC_19915707_ChIP-ChIP_AK7_Human0.52180545
108NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.51830102
109STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51265713
110CDX2_20551321_ChIP-Seq_CACO-2_Human0.51123750
111FOXA1_25552417_ChIP-Seq_VCAP_Human0.50743748
112SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.48545191
113P53_21459846_ChIP-Seq_SAOS-2_Human0.47822409
114* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.47819606
115SOX2_20726797_ChIP-Seq_SW620_Human0.47428613
116TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.47342293
117FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.46936445
118SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.45848221
119ESR1_20079471_ChIP-ChIP_T-47D_Human0.45338736
120TRIM28_21343339_ChIP-Seq_HEK293_Human0.45240679
121TBX20_22328084_ChIP-Seq_HEART_Mouse0.45216355
122TBX20_22080862_ChIP-Seq_HEART_Mouse0.45216355
123BCAT_22108803_ChIP-Seq_LS180_Human0.45159379
124NFIB_24661679_ChIP-Seq_LUNG_Mouse0.44792247
125ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.43683362
126BCOR_27268052_Chip-Seq_Bcells_Human0.43602971
127TAF2_19829295_ChIP-Seq_ESCs_Human0.42983501
128EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.42952822
129FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.42881866
130SPI1_20517297_ChIP-Seq_HL60_Human0.42532805

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.54864599
2MP0005360_urolithiasis6.91597401
3MP0005085_abnormal_gallbladder_physiolo5.86311128
4MP0005365_abnormal_bile_salt5.77514249
5MP0008875_abnormal_xenobiotic_pharmacok4.64188421
6MP0010329_abnormal_lipoprotein_level3.77140604
7MP0003806_abnormal_nucleotide_metabolis3.67686510
8MP0003252_abnormal_bile_duct3.60989791
9MP0009840_abnormal_foam_cell3.57789834
10MP0005083_abnormal_biliary_tract2.86684579
11MP0003191_abnormal_cellular_cholesterol2.85418789
12MP0005332_abnormal_amino_acid2.65963099
13MP0003195_calcinosis2.56846956
14MP0001666_abnormal_nutrient_absorption2.38611321
15MP0002118_abnormal_lipid_homeostasis2.23792432
16* MP0000609_abnormal_liver_physiology2.19104953
17MP0004019_abnormal_vitamin_homeostasis2.02871416
18MP0002138_abnormal_hepatobiliary_system1.87211093
19MP0003705_abnormal_hypodermis_morpholog1.81527240
20MP0005319_abnormal_enzyme/_coenzyme1.81003548
21MP0002909_abnormal_adrenal_gland1.75709022
22MP0005670_abnormal_white_adipose1.73151554
23MP0005584_abnormal_enzyme/coenzyme_acti1.58319985
24MP0003868_abnormal_feces_composition1.56834043
25MP0001764_abnormal_homeostasis1.52686770
26MP0000604_amyloidosis1.39462726
27MP0002254_reproductive_system_inflammat1.36588211
28MP0003879_abnormal_hair_cell1.36052982
29MP0003011_delayed_dark_adaptation1.35003981
30MP0010368_abnormal_lymphatic_system1.25209344
31MP0009643_abnormal_urine_homeostasis1.25046937
32MP0003656_abnormal_erythrocyte_physiolo1.23757022
33MP0004130_abnormal_muscle_cell1.22401722
34MP0000598_abnormal_liver_morphology1.20737976
35MP0003724_increased_susceptibility_to1.19773101
36MP0008004_abnormal_stomach_pH1.18875746
37MP0003690_abnormal_glial_cell1.17393286
38MP0001915_intracranial_hemorrhage1.16789376
39MP0003186_abnormal_redox_activity1.16013813
40MP0005451_abnormal_body_composition1.12424119
41* MP0009763_increased_sensitivity_to1.11567312
42MP0002971_abnormal_brown_adipose1.09118367
43MP0009697_abnormal_copulation1.07433965
44MP0000678_abnormal_parathyroid_gland1.07069130
45MP0005647_abnormal_sex_gland1.03906086
46MP0009764_decreased_sensitivity_to1.03773977
47MP0000566_synostosis1.01797316
48MP0008469_abnormal_protein_level0.98864865
49MP0003436_decreased_susceptibility_to0.98449248
50MP0005058_abnormal_lysosome_morphology0.95723881
51MP0005666_abnormal_adipose_tissue0.94705827
52MP0003075_altered_response_to0.94331160
53MP0002132_abnormal_respiratory_system0.93467037
54MP0008438_abnormal_cutaneous_collagen0.93183262
55MP0005334_abnormal_fat_pad0.92333584
56MP0009642_abnormal_blood_homeostasis0.89756249
57MP0009780_abnormal_chondrocyte_physiolo0.88952579
58MP0002249_abnormal_larynx_morphology0.87364291
59MP0003329_amyloid_beta_deposits0.86091996
60MP0005535_abnormal_body_temperature0.85787759
61MP0004272_abnormal_basement_membrane0.85544423
62MP0002078_abnormal_glucose_homeostasis0.82107261
63MP0002876_abnormal_thyroid_physiology0.80698677
64MP0005464_abnormal_platelet_physiology0.80347204
65MP0000920_abnormal_myelination0.79300755
66MP0005409_darkened_coat_color0.78541108
67MP0005636_abnormal_mineral_homeostasis0.78175987
68MP0001661_extended_life_span0.72923866
69MP0005448_abnormal_energy_balance0.71548518
70MP0005376_homeostasis/metabolism_phenot0.71257011
71MP0003566_abnormal_cell_adhesion0.70693709
72MP0005377_hearing/vestibular/ear_phenot0.70162293
73MP0003878_abnormal_ear_physiology0.70162293
74MP0009765_abnormal_xenobiotic_induced0.69451255
75MP0001756_abnormal_urination0.68478375
76MP0005220_abnormal_exocrine_pancreas0.68462293
77MP0004185_abnormal_adipocyte_glucose0.64341884
78MP0006036_abnormal_mitochondrial_physio0.64135372
79MP0005408_hypopigmentation0.63993810
80MP0005595_abnormal_vascular_smooth0.63742622
81MP0001984_abnormal_olfaction0.60338172
82MP0005166_decreased_susceptibility_to0.60231606
83MP0005084_abnormal_gallbladder_morpholo0.60086695
84MP0009115_abnormal_fat_cell0.59999351
85MP0002282_abnormal_trachea_morphology0.59882675
86MP0009053_abnormal_anal_canal0.59665251
87MP0002933_joint_inflammation0.58520983
88MP0003638_abnormal_response/metabolism_0.58304149
89MP0002168_other_aberrant_phenotype0.57619661
90MP0001533_abnormal_skeleton_physiology0.55220845
91MP0003632_abnormal_nervous_system0.54845616
92MP0002089_abnormal_postnatal_growth/wei0.54397205
93MP0002896_abnormal_bone_mineralization0.53394545
94* MP0002136_abnormal_kidney_physiology0.52917757
95MP0000639_abnormal_adrenal_gland0.52335110
96MP0002837_dystrophic_cardiac_calcinosis0.52188812
97* MP0000249_abnormal_blood_vessel0.51944877
98MP0005395_other_phenotype0.51065415
99MP0004782_abnormal_surfactant_physiolog0.50591409
100MP0003172_abnormal_lysosome_physiology0.50080855
101MP0004947_skin_inflammation0.49323892
102MP0002060_abnormal_skin_morphology0.48684525
103MP0008874_decreased_physiological_sensi0.48642364
104MP0002970_abnormal_white_adipose0.48544481
105MP0004858_abnormal_nervous_system0.47770128
106MP0005375_adipose_tissue_phenotype0.47629603
107MP0002796_impaired_skin_barrier0.47433043
108MP0005023_abnormal_wound_healing0.47392299
109MP0003633_abnormal_nervous_system0.46851444
110MP0005266_abnormal_metabolism0.45674341
111MP0008873_increased_physiological_sensi0.45016675
112MP0003279_aneurysm0.44848491
113MP0002295_abnormal_pulmonary_circulatio0.44210686
114MP0002419_abnormal_innate_immunity0.44162657
115MP0001881_abnormal_mammary_gland0.44111779
116MP0002998_abnormal_bone_remodeling0.42974990
117MP0002928_abnormal_bile_duct0.42903948
118MP0001853_heart_inflammation0.42022866
119* MP0001845_abnormal_inflammatory_respons0.41483883
120MP0003953_abnormal_hormone_level0.40883807
121MP0000230_abnormal_systemic_arterial0.40767219
122MP0005164_abnormal_response_to0.40726914
123MP0003300_gastrointestinal_ulcer0.40060464
124MP0005167_abnormal_blood-brain_barrier0.40036489
125MP0005248_abnormal_Harderian_gland0.38777736
126MP0009384_cardiac_valve_regurgitation0.38549114
127MP0004883_abnormal_blood_vessel0.38152093
128MP0006082_CNS_inflammation0.37770593

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.44906256
2Complement deficiency (HP:0004431)7.05290263
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.54506598
4Prolonged partial thromboplastin time (HP:0003645)6.51946428
5Intrahepatic cholestasis (HP:0001406)6.47262843
6Xanthomatosis (HP:0000991)6.07657533
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.98302251
8Abnormality of complement system (HP:0005339)5.57182915
9Hypobetalipoproteinemia (HP:0003563)5.52825142
10Systemic lupus erythematosus (HP:0002725)5.45327374
11Hyperlipoproteinemia (HP:0010980)5.17700855
12Abnormality of the common coagulation pathway (HP:0010990)4.78506449
13Joint hemorrhage (HP:0005261)4.74127661
14Hypolipoproteinemia (HP:0010981)4.39432124
15Epidermoid cyst (HP:0200040)4.35128426
16Hyperammonemia (HP:0001987)4.18913146
17Hypoalphalipoproteinemia (HP:0003233)4.11381860
18Glomerulonephritis (HP:0000099)4.07115497
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.06869041
20Hyperglycinemia (HP:0002154)3.99742724
21Ketosis (HP:0001946)3.89491056
22Hyperglycinuria (HP:0003108)3.75695187
23Abnormality of glutamine family amino acid metabolism (HP:0010902)3.75531370
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.70966188
25Abnormality of glycine metabolism (HP:0010895)3.66497295
26Abnormality of serine family amino acid metabolism (HP:0010894)3.66497295
27Hypoglycemic coma (HP:0001325)3.60526962
28Fat malabsorption (HP:0002630)3.60140808
29Hypercholesterolemia (HP:0003124)3.58245463
30Abnormality of methionine metabolism (HP:0010901)3.57109596
31Abnormality of the intrinsic pathway (HP:0010989)3.51305920
32Abnormality of aspartate family amino acid metabolism (HP:0010899)3.48970122
33Myocardial infarction (HP:0001658)3.29794057
34Recurrent gram-negative bacterial infections (HP:0005420)3.21601097
35Conjugated hyperbilirubinemia (HP:0002908)3.18038296
36Purpura (HP:0000979)3.13880055
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.13246735
38Abnormality of pyrimidine metabolism (HP:0004353)3.12648509
39Abnormality of fatty-acid metabolism (HP:0004359)3.08045577
40Spontaneous abortion (HP:0005268)3.07049978
41Hyperbilirubinemia (HP:0002904)2.87924764
42Skin nodule (HP:0200036)2.79500368
43Ketoacidosis (HP:0001993)2.79126839
44Abnormality of nucleobase metabolism (HP:0010932)2.76108070
45Nephritis (HP:0000123)2.75715876
46Mitral stenosis (HP:0001718)2.75256878
47Amyloidosis (HP:0011034)2.73571270
48Delayed CNS myelination (HP:0002188)2.70992377
49Hepatocellular carcinoma (HP:0001402)2.65627404
50Steatorrhea (HP:0002570)2.64910525
51Abnormality of purine metabolism (HP:0004352)2.57837851
52Abnormality of serum amino acid levels (HP:0003112)2.57286644
53Esophageal varix (HP:0002040)2.51814121
54Menorrhagia (HP:0000132)2.51630706
55Vascular calcification (HP:0004934)2.44768008
56Gingival bleeding (HP:0000225)2.41639544
57Hypochromic microcytic anemia (HP:0004840)2.39970945
58Hemorrhage of the eye (HP:0011885)2.35787419
59Metabolic acidosis (HP:0001942)2.31366979
60Hypoglycemic seizures (HP:0002173)2.28369309
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.27457521
62Dicarboxylic aciduria (HP:0003215)2.27457521
63Abnormal gallbladder morphology (HP:0012437)2.26850157
64Spastic diplegia (HP:0001264)2.25046198
65Cholelithiasis (HP:0001081)2.24082013
66Cardiovascular calcification (HP:0011915)2.22408615
67Abnormal gallbladder physiology (HP:0012438)2.20965030
68Cholecystitis (HP:0001082)2.20965030
69Acanthocytosis (HP:0001927)2.17150591
70Decreased circulating renin level (HP:0003351)2.15812256
71Rickets (HP:0002748)2.15407524
72Lethargy (HP:0001254)2.13285073
73Irritability (HP:0000737)2.12665574
74Gout (HP:0001997)2.11836708
75Thrombophlebitis (HP:0004418)2.11643706
76Neonatal onset (HP:0003623)2.08266611
77Sensorimotor neuropathy (HP:0007141)2.08141358
78Late onset (HP:0003584)2.06771139
79Potter facies (HP:0002009)2.01787237
80Facial shape deformation (HP:0011334)2.01787237
81Malnutrition (HP:0004395)2.01702066
82Hypertriglyceridemia (HP:0002155)1.99197171
83Pancreatitis (HP:0001733)1.96633572
84Orchitis (HP:0100796)1.96532016
85Abnormality of proline metabolism (HP:0010907)1.88748857
86Hydroxyprolinuria (HP:0003080)1.88748857
87Optic neuritis (HP:0100653)1.87129422
88Retrobulbar optic neuritis (HP:0100654)1.87129422
89Joint swelling (HP:0001386)1.86880882
90Peritonitis (HP:0002586)1.86039944
91Abnormality of iron homeostasis (HP:0011031)1.84742925
92Brushfield spots (HP:0001088)1.84030715
93Abnormality of the gallbladder (HP:0005264)1.83420297
94Vomiting (HP:0002013)1.83044607
95Turricephaly (HP:0000262)1.82722205
96Neurofibrillary tangles (HP:0002185)1.82250530
97Osteomalacia (HP:0002749)1.81753004
98Acute hepatic failure (HP:0006554)1.80941855
99Abnormal cartilage morphology (HP:0002763)1.79851839
100Cerebral edema (HP:0002181)1.79767088
101Hyperinsulinemic hypoglycemia (HP:0000825)1.78939729
102Opisthotonus (HP:0002179)1.78365973
103Abnormality of transition element cation homeostasis (HP:0011030)1.78157075
104Renal salt wasting (HP:0000127)1.77791351
105Enlarged kidneys (HP:0000105)1.76664832
106Pulmonary embolism (HP:0002204)1.72912167
107Lymphangioma (HP:0100764)1.71240821
108Hyperglycemia (HP:0003074)1.70003654
109Elevated hepatic transaminases (HP:0002910)1.68576025
110Enlarged penis (HP:0000040)1.68020049
111Atrioventricular block (HP:0001678)1.66271469
112Generalized aminoaciduria (HP:0002909)1.66266118
113Stroke (HP:0001297)1.66184658
114Gangrene (HP:0100758)1.65913487
115Abnormal delivery (HP:0001787)1.65697334
116Epistaxis (HP:0000421)1.64142125
117Poikilocytosis (HP:0004447)1.63456875
118Arthropathy (HP:0003040)1.63070155
119Hyperaldosteronism (HP:0000859)1.58656747
120Bifid scrotum (HP:0000048)1.57573057
121Elevated alkaline phosphatase (HP:0003155)1.55470936
122Mesangial abnormality (HP:0001966)1.53148387
123Visceral angiomatosis (HP:0100761)1.51275086
124Abnormality of carpal bone ossification (HP:0006257)1.50875606
125Protrusio acetabuli (HP:0003179)1.48654375
126Urinary glycosaminoglycan excretion (HP:0003541)1.48055687
127Mucopolysacchariduria (HP:0008155)1.48055687
128Cerebral palsy (HP:0100021)1.46494115
129Abnormal enzyme/coenzyme activity (HP:0012379)1.45306523
130Increased serum ferritin (HP:0003281)1.45255001
131J-shaped sella turcica (HP:0002680)1.45162398
132Abnormality of the Achilles tendon (HP:0005109)1.44979479
133Alkalosis (HP:0001948)1.44796908
134Myositis (HP:0100614)1.43717620
135Abnormality of alkaline phosphatase activity (HP:0004379)1.43711507
136Hypophosphatemia (HP:0002148)1.41568506
137Abnormal tarsal ossification (HP:0008369)1.40647059
138Hemangiomatosis (HP:0007461)1.39714245

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.96640577
2ERN14.82160391
3MST1R4.40991869
4SIK14.17235445
5FGFR43.87361824
6AKT33.41163351
7TRIB33.01070520
8TAOK32.88244282
9CAMK1D2.59278633
10INSRR2.43756120
11DAPK22.22837853
12PKN22.11896796
13ERBB42.07202005
14DDR21.94165296
15TYK21.86457682
16RIPK11.85184074
17CAMK1G1.83889388
18MET1.80392352
19MAP2K41.75248339
20PTK61.65911812
21NTRK31.62363101
22EPHB11.52731375
23MAPK111.44851878
24JAK11.28873630
25TGFBR21.24290908
26JAK21.20621463
27FER1.20290640
28PIK3CG1.19672483
29MAP3K71.17610300
30NTRK11.17084378
31LATS11.16280364
32NLK1.15600240
33PRKAA21.14627073
34NEK91.11646260
35FLT31.11566559
36PIK3CA1.11094445
37GRK61.09927599
38FGFR21.08657955
39MAP2K31.06668140
40TBK11.06122698
41EPHA31.02596645
42BMX1.02572654
43PRPF4B0.99219698
44ABL20.98524202
45BLK0.97586246
46SGK4940.97298129
47SGK2230.97298129
48CSK0.95242680
49EEF2K0.93690427
50MARK20.91906417
51KDR0.91331625
52MAP3K20.90662078
53FGFR30.88502925
54FRK0.87233026
55PDGFRB0.85558958
56ERBB20.84212767
57MELK0.83354223
58CDC42BPA0.81689468
59MAPK120.81113568
60MAP3K110.79933726
61TIE10.74380931
62MYLK0.72976188
63SMG10.70101604
64MAP3K130.68548645
65MAP3K100.68330321
66CDK120.68181114
67MAPK40.68029907
68MAP4K10.68024432
69PRKCH0.66092966
70SGK30.65479589
71SGK10.65079649
72PRKCZ0.64941182
73PRKACG0.64372838
74MAP3K60.64254324
75MAP3K140.63858405
76PDPK10.63798854
77MAP3K30.63564934
78IGF1R0.63119633
79MAP3K50.63007185
80NEK60.62522234
81CDK60.61888493
82GSK3A0.61252660
83HIPK20.60221403
84EPHB20.59792965
85LMTK20.58674673
86PDK20.58432501
87KIT0.58078971
88CSF1R0.56043291
89PINK10.55786193
90IRAK30.55378976
91TNK20.54303398
92PTK20.54257468
93RET0.53449340
94PRKAA10.52940504
95ICK0.51645025
96MAPK30.51600131
97MAPKAPK30.49778581
98IKBKE0.49419707
99CAMK2G0.48781208
100TYRO30.47535843
101PDGFRA0.47368733
102MAPK150.45531204
103PKN10.45500509
104PRKD10.45170567
105EGFR0.43833650
106DYRK1B0.42703642
107SRC0.42663719
108STK380.41803644
109FGFR10.41667070
110CAMKK10.41505752
111MAP2K60.40544004
112TTN0.40050828
113MAP3K10.39037722
114AKT20.38407137
115RPS6KA20.38365295
116MAPK70.38092985
117CAMK40.37696759
118MTOR0.36887295
119MAP2K10.36567560
120ZAP700.36325899
121JAK30.36250736
122PRKG10.35892285
123PDK10.35004799
124TRPM70.34593006
125RPS6KA30.33511747
126CDK40.30517712
127DAPK10.29762078
128SGK20.27954291
129PDK30.27656421
130PDK40.27656421
131IRAK10.27392295
132PRKCQ0.27232087
133HCK0.26912199
134DAPK30.24864625
135LRRK20.21471665
136EPHA20.21186413

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.38113552
2Nitrogen metabolism_Homo sapiens_hsa009103.88735886
3* Complement and coagulation cascades_Homo sapiens_hsa046103.30143602
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.11762559
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.11521043
6Arginine biosynthesis_Homo sapiens_hsa002202.99317924
7* Staphylococcus aureus infection_Homo sapiens_hsa051502.69221727
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.60078117
9Tryptophan metabolism_Homo sapiens_hsa003802.55910217
10Fatty acid degradation_Homo sapiens_hsa000712.52317811
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.49856036
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36983658
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.32765220
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.15309070
15Caffeine metabolism_Homo sapiens_hsa002322.13329067
16PPAR signaling pathway_Homo sapiens_hsa033202.11679567
17Peroxisome_Homo sapiens_hsa041462.03164713
18Butanoate metabolism_Homo sapiens_hsa006501.96865295
19Propanoate metabolism_Homo sapiens_hsa006401.96313069
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.92530495
21Fatty acid metabolism_Homo sapiens_hsa012121.91999754
22Histidine metabolism_Homo sapiens_hsa003401.88080649
23Chemical carcinogenesis_Homo sapiens_hsa052041.74890536
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.70192113
25beta-Alanine metabolism_Homo sapiens_hsa004101.69202805
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.67623261
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.62187206
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.61532078
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53612000
30Retinol metabolism_Homo sapiens_hsa008301.52565680
31Phenylalanine metabolism_Homo sapiens_hsa003601.49627206
32Bile secretion_Homo sapiens_hsa049761.47948011
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.46320553
34Selenocompound metabolism_Homo sapiens_hsa004501.40501321
35Tyrosine metabolism_Homo sapiens_hsa003501.39163501
36Pyruvate metabolism_Homo sapiens_hsa006201.34189024
37ABC transporters_Homo sapiens_hsa020101.31261075
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30683070
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26421734
40Starch and sucrose metabolism_Homo sapiens_hsa005001.25727623
41Fatty acid elongation_Homo sapiens_hsa000621.20553012
42Fat digestion and absorption_Homo sapiens_hsa049751.17703688
43Sulfur metabolism_Homo sapiens_hsa009201.12759828
44Biosynthesis of amino acids_Homo sapiens_hsa012301.09600733
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.09439993
46Carbon metabolism_Homo sapiens_hsa012001.07173967
47Folate biosynthesis_Homo sapiens_hsa007901.05783175
48Steroid biosynthesis_Homo sapiens_hsa001000.95499305
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94648810
50Sulfur relay system_Homo sapiens_hsa041220.93281235
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92013341
52Vitamin B6 metabolism_Homo sapiens_hsa007500.89807486
53Fatty acid biosynthesis_Homo sapiens_hsa000610.88723406
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86708449
55Lysine degradation_Homo sapiens_hsa003100.86372754
56Arginine and proline metabolism_Homo sapiens_hsa003300.81599674
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.81287547
58Vitamin digestion and absorption_Homo sapiens_hsa049770.80560701
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79932305
60Glycerolipid metabolism_Homo sapiens_hsa005610.78936497
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.73307749
62Prion diseases_Homo sapiens_hsa050200.69111469
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64979732
64Pentose phosphate pathway_Homo sapiens_hsa000300.54474609
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53532904
66Glutathione metabolism_Homo sapiens_hsa004800.48951603
67One carbon pool by folate_Homo sapiens_hsa006700.48567975
68Linoleic acid metabolism_Homo sapiens_hsa005910.44970571
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.44474416
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.44236604
71Other glycan degradation_Homo sapiens_hsa005110.41879845
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39311745
73Insulin resistance_Homo sapiens_hsa049310.39286639
74Metabolic pathways_Homo sapiens_hsa011000.37839739
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33657461
76ECM-receptor interaction_Homo sapiens_hsa045120.27707057
77Galactose metabolism_Homo sapiens_hsa000520.25234728
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22759732
79Fructose and mannose metabolism_Homo sapiens_hsa000510.20749896
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.19958294
81Mineral absorption_Homo sapiens_hsa049780.19903344
82Glucagon signaling pathway_Homo sapiens_hsa049220.17572021
83AMPK signaling pathway_Homo sapiens_hsa041520.15515625
84* Systemic lupus erythematosus_Homo sapiens_hsa053220.14871412
85Arachidonic acid metabolism_Homo sapiens_hsa005900.14177757
86Protein digestion and absorption_Homo sapiens_hsa049740.09043379
87* Pertussis_Homo sapiens_hsa051330.04977284
88Lysosome_Homo sapiens_hsa041420.04906103
89Circadian rhythm_Homo sapiens_hsa047100.04437607
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.03639942
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.03325927
92Insulin signaling pathway_Homo sapiens_hsa049100.00618890
93Amoebiasis_Homo sapiens_hsa051460.00440446
94African trypanosomiasis_Homo sapiens_hsa05143-0.1752826
95Renin-angiotensin system_Homo sapiens_hsa04614-0.1725054
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1718329
97Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1639596
98Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1630056
99Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1609167
100Hepatitis C_Homo sapiens_hsa05160-0.0971630
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0956853
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0923433
103Serotonergic synapse_Homo sapiens_hsa04726-0.0833831
104Sphingolipid metabolism_Homo sapiens_hsa00600-0.0684118
105Pancreatic secretion_Homo sapiens_hsa04972-0.0637645
106Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0548073
107Focal adhesion_Homo sapiens_hsa04510-0.0531653
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0507276
109Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0435990
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0357202
111Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0311310
112Malaria_Homo sapiens_hsa05144-0.0252298
113Prolactin signaling pathway_Homo sapiens_hsa04917-0.0107496

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