C3ORF52

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)6.42549245
2bundle of His cell to Purkinje myocyte communication (GO:0086069)5.75706780
3nuclear pore complex assembly (GO:0051292)5.24452262
4regulation of water loss via skin (GO:0033561)5.19028824
5establishment of skin barrier (GO:0061436)5.17101432
6ribosome assembly (GO:0042255)4.60836108
7intestinal epithelial cell development (GO:0060576)4.47044604
8nuclear pore organization (GO:0006999)4.37730460
9cellular protein complex localization (GO:0034629)4.21918310
10pore complex assembly (GO:0046931)3.71653667
11hemidesmosome assembly (GO:0031581)3.63395208
12nucleotide-sugar biosynthetic process (GO:0009226)3.55723034
13protein complex localization (GO:0031503)3.46823781
14UDP-N-acetylglucosamine metabolic process (GO:0006047)3.38070985
15multicellular organismal water homeostasis (GO:0050891)3.36768426
16regulation of transforming growth factor beta2 production (GO:0032909)3.31935301
17tight junction assembly (GO:0070830)3.30411663
18negative regulation of keratinocyte proliferation (GO:0010839)3.21159591
19skin morphogenesis (GO:0043589)3.19112637
20regulation of transforming growth factor beta1 production (GO:0032908)3.18851930
21mitotic sister chromatid cohesion (GO:0007064)3.18461558
22regulation of keratinocyte differentiation (GO:0045616)3.08678748
23calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.05370956
24regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.02236864
25keratinization (GO:0031424)2.97122885
26keratinocyte proliferation (GO:0043616)2.95846607
27regulation of cardioblast differentiation (GO:0051890)2.94960945
28Golgi transport vesicle coating (GO:0048200)2.93860056
29COPI coating of Golgi vesicle (GO:0048205)2.93860056
30regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.91068082
31COPII vesicle coating (GO:0048208)2.87208903
32negative regulation of DNA repair (GO:0045738)2.86076910
33rRNA methylation (GO:0031167)2.86061448
34mitotic metaphase plate congression (GO:0007080)2.82401936
35trophoblast giant cell differentiation (GO:0060707)2.75849364
36cell adhesion mediated by integrin (GO:0033627)2.70037546
37ER overload response (GO:0006983)2.67902423
38NLS-bearing protein import into nucleus (GO:0006607)2.67720570
39notochord development (GO:0030903)2.67305592
40membrane raft organization (GO:0031579)2.67168482
41gap junction assembly (GO:0016264)2.66090778
42water homeostasis (GO:0030104)2.65539942
43cell-cell junction assembly (GO:0007043)2.65411418
44regulation of hippo signaling (GO:0035330)2.63276757
45anterior/posterior axis specification, embryo (GO:0008595)2.60689161
46rRNA modification (GO:0000154)2.60574074
47regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.60421264
48regulation of centriole replication (GO:0046599)2.58507296
49chromosome condensation (GO:0030261)2.57942045
50metaphase plate congression (GO:0051310)2.56302983
51epithelial cell-cell adhesion (GO:0090136)2.56131036
52regulation of keratinocyte proliferation (GO:0010837)2.55121007
53regulation of DNA endoreduplication (GO:0032875)2.53863680
54peptidyl-proline hydroxylation (GO:0019511)2.53725837
55keratinocyte differentiation (GO:0030216)2.52805621
56hippo signaling (GO:0035329)2.51378620
57DNA packaging (GO:0006323)2.47002629
58protein hydroxylation (GO:0018126)2.46694811
59response to X-ray (GO:0010165)2.44817216
60mesodermal cell differentiation (GO:0048333)2.44508102
61mitotic nuclear envelope disassembly (GO:0007077)2.41524383
62chemical homeostasis within a tissue (GO:0048875)2.40487544
63regulation of apoptotic process involved in morphogenesis (GO:1902337)2.38101024
64nodal signaling pathway (GO:0038092)2.36210494
65mammary gland epithelial cell proliferation (GO:0033598)2.35873109
66lung lobe morphogenesis (GO:0060463)2.35539007
67hypotonic response (GO:0006971)2.34684649
68glomerular visceral epithelial cell development (GO:0072015)2.31775972
69dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.31251691
70protein localization to kinetochore (GO:0034501)2.30359103
71regulation of transforming growth factor beta production (GO:0071634)2.30344418
72positive regulation of cell size (GO:0045793)2.29060445
73regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.28953267
74positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.28953267
75positive regulation of catenin import into nucleus (GO:0035413)2.28380376
76hepatocyte differentiation (GO:0070365)2.27906413
77keratinocyte development (GO:0003334)2.27298368
78regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.27160876
79mitotic chromosome condensation (GO:0007076)2.26508209
80positive regulation of protein autophosphorylation (GO:0031954)2.25527994
81protein localization to chromosome, centromeric region (GO:0071459)2.25365991
82positive regulation of chromosome segregation (GO:0051984)2.25159744
83glomerular epithelial cell development (GO:0072310)2.23604880
84membrane disassembly (GO:0030397)2.22940172
85nuclear envelope disassembly (GO:0051081)2.22940172
86axonemal dynein complex assembly (GO:0070286)2.20704466
87cell-substrate junction assembly (GO:0007044)2.20302981
88folic acid-containing compound biosynthetic process (GO:0009396)2.19913898
89positive regulation of keratinocyte differentiation (GO:0045618)2.19673498
90tRNA methylation (GO:0030488)2.19370674
91regulation of centrosome duplication (GO:0010824)2.19222755
92protein localization to microtubule (GO:0035372)2.19078961
93mitotic sister chromatid segregation (GO:0000070)2.18616861
94intestinal cholesterol absorption (GO:0030299)2.17327447
95regulation of centrosome cycle (GO:0046605)2.16349191
96epidermal cell differentiation (GO:0009913)2.16244982
97positive regulation of protein import into nucleus, translocation (GO:0033160)2.15647075
98diterpenoid biosynthetic process (GO:0016102)2.14973497
99regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.14748521
100pteridine-containing compound biosynthetic process (GO:0042559)2.14225211

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.45147473
2E2F7_22180533_ChIP-Seq_HELA_Human4.69545407
3SMAD4_19686287_ChIP-ChIP_HaCaT_Human4.59050692
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.83267382
5AR_21909140_ChIP-Seq_LNCAP_Human3.20346386
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.85552533
7* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.75084798
8* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.75084798
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.70864947
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.53872602
11ZNF217_24962896_ChIP-Seq_MCF-7_Human2.48164467
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.39841110
13FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human2.34422622
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.25337671
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.17497399
16PPAR_26484153_Chip-Seq_NCI-H1993_Human2.15265199
17GATA6_25053715_ChIP-Seq_YYC3_Human2.13363241
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.12607180
19FOXO3_23340844_ChIP-Seq_DLD1_Human2.10689550
20KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.10532287
21E2F4_17652178_ChIP-ChIP_JURKAT_Human1.88744908
22KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81685581
23FOXM1_26456572_ChIP-Seq_MCF-7_Human1.79598481
24SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.75546824
25SOX2_27498859_Chip-Seq_STOMACH_Mouse1.73591795
26* GATA3_24758297_ChIP-Seq_MCF-7_Human1.71299263
27* GATA4_25053715_ChIP-Seq_YYC3_Human1.69738950
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.65859973
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.64984017
30AHR_22903824_ChIP-Seq_MCF-7_Human1.62690435
31CDX2_20551321_ChIP-Seq_CACO-2_Human1.57731512
32CJUN_26792858_Chip-Seq_BT549_Human1.55189147
33ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.54728774
34KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.53348234
35EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.52675862
36PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.52447764
37SOX9_24532713_ChIP-Seq_HFSC_Mouse1.52352016
38ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.47764373
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.46029256
40PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45410908
41SOX2_20726797_ChIP-Seq_SW620_Human1.44879662
42ATF3_27146783_Chip-Seq_COLON_Human1.43611979
43FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42409736
44ELK1_19687146_ChIP-ChIP_HELA_Human1.40344819
45BRD4_25478319_ChIP-Seq_HGPS_Human1.39830259
46TP63_23658742_ChIP-Seq_EP156T_Human1.37611025
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.37192680
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35873651
49CHD1_26751641_Chip-Seq_LNCaP_Human1.32896585
50HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.32799902
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32025204
52FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.30641435
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.28175241
54ZNF263_19887448_ChIP-Seq_K562_Human1.27772986
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23940023
56TRIM28_21343339_ChIP-Seq_HEK293_Human1.21710363
57ELF5_23300383_ChIP-Seq_T47D_Human1.21063699
58* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17598318
59MYC_19030024_ChIP-ChIP_MESCs_Mouse1.16454715
60KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15000888
61DCP1A_22483619_ChIP-Seq_HELA_Human1.14894970
62P63_26484246_Chip-Seq_KERATINOCYTES_Human1.14585275
63HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14078458
64SALL4_18804426_ChIP-ChIP_XEN_Mouse1.13656520
65RUNX1_27514584_Chip-Seq_MCF-7_Human1.12518342
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.11798417
67SALL1_21062744_ChIP-ChIP_HESCs_Human1.11620250
68PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.11482119
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10201481
70MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09305184
71CLOCK_20551151_ChIP-Seq_293T_Human1.08897656
72EGR1_19374776_ChIP-ChIP_THP-1_Human1.08825630
73FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.08286905
74RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08236672
75* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07988618
76ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.07701596
77CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05826349
78TP53_18474530_ChIP-ChIP_U2OS_Human1.04848064
79CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04114650
80MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03032317
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02884647
82CDX2_22108803_ChIP-Seq_LS180_Human0.98093398
83TFEB_21752829_ChIP-Seq_HELA_Human0.96905653
84AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96762462
85UBF1/2_26484160_Chip-Seq_HMECs_Human0.95571267
86KLF5_25053715_ChIP-Seq_YYC3_Human0.93943510
87SOX17_20123909_ChIP-Seq_XEN_Mouse0.93366964
88GATA2_21666600_ChIP-Seq_HMVEC_Human0.92859781
89TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91923638
90CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91744064
91KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91203603
92TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91055637
93STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89434892
94ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88379676
95FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.85109304
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84240584
97ELK1_22589737_ChIP-Seq_MCF10A_Human0.83873862
98ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82980325
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82469165
100TCF4_18268006_ChIP-ChIP_LS174T_Human0.81325252

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.55824333
2MP0002796_impaired_skin_barrier4.05610660
3MP0003941_abnormal_skin_development3.80241059
4MP0008057_abnormal_DNA_replication3.36329177
5MP0010352_gastrointestinal_tract_polyps3.33299945
6MP0010678_abnormal_skin_adnexa2.82003706
7MP0003566_abnormal_cell_adhesion2.73085348
8MP0003950_abnormal_plasma_membrane2.57969919
9MP0005501_abnormal_skin_physiology2.49174808
10MP0004957_abnormal_blastocyst_morpholog2.39917071
11MP0003453_abnormal_keratinocyte_physiol2.27168972
12MP0003693_abnormal_embryo_hatching2.15724232
13MP0004264_abnormal_extraembryonic_tissu2.13839043
14MP0000383_abnormal_hair_follicle2.12237619
15MP0001216_abnormal_epidermal_layer1.89747328
16MP0005023_abnormal_wound_healing1.82581718
17MP0002060_abnormal_skin_morphology1.82490421
18MP0004272_abnormal_basement_membrane1.82431797
19MP0010094_abnormal_chromosome_stability1.82393836
20MP0000579_abnormal_nail_morphology1.81498587
21MP0003077_abnormal_cell_cycle1.75831075
22MP0001666_abnormal_nutrient_absorption1.71185466
23MP0010307_abnormal_tumor_latency1.68710319
24MP0005275_abnormal_skin_tensile1.65974956
25MP0004233_abnormal_muscle_weight1.60442894
26MP0003111_abnormal_nucleus_morphology1.60166227
27MP0003718_maternal_effect1.58204596
28MP0004782_abnormal_surfactant_physiolog1.52894397
29MP0009697_abnormal_copulation1.51755094
30MP0005623_abnormal_meninges_morphology1.43808585
31MP0010771_integument_phenotype1.43227896
32MP0000627_abnormal_mammary_gland1.41970765
33MP0000762_abnormal_tongue_morphology1.39778707
34MP0001873_stomach_inflammation1.37826150
35MP0005076_abnormal_cell_differentiation1.36835970
36MP0002098_abnormal_vibrissa_morphology1.34606891
37MP0001346_abnormal_lacrimal_gland1.33269741
38MP0003868_abnormal_feces_composition1.31679710
39MP0008932_abnormal_embryonic_tissue1.29106673
40MP0009780_abnormal_chondrocyte_physiolo1.28409579
41MP0003091_abnormal_cell_migration1.27150504
42MP0000350_abnormal_cell_proliferation1.26958940
43MP0002254_reproductive_system_inflammat1.19701809
44MP0003786_premature_aging1.19059217
45MP0001730_embryonic_growth_arrest1.18778913
46MP0002138_abnormal_hepatobiliary_system1.14991536
47MP0002086_abnormal_extraembryonic_tissu1.14001144
48MP0001672_abnormal_embryogenesis/_devel1.13541483
49MP0005380_embryogenesis_phenotype1.13541483
50MP0008058_abnormal_DNA_repair1.12687648
51MP0000537_abnormal_urethra_morphology1.11883003
52MP0008007_abnormal_cellular_replicative1.11165926
53MP0003984_embryonic_growth_retardation1.09843270
54MP0003705_abnormal_hypodermis_morpholog1.09084575
55MP0001697_abnormal_embryo_size1.08083178
56MP0002088_abnormal_embryonic_growth/wei1.07168222
57MP0000377_abnormal_hair_follicle1.07062074
58MP0002877_abnormal_melanocyte_morpholog1.06477122
59MP0004947_skin_inflammation1.04113680
60MP0001191_abnormal_skin_condition1.02250484
61MP0001881_abnormal_mammary_gland1.00391970
62MP0000467_abnormal_esophagus_morphology0.99845798
63MP0005395_other_phenotype0.98407938
64MP0002084_abnormal_developmental_patter0.98270137
65MP0003890_abnormal_embryonic-extraembry0.94267083
66MP0003300_gastrointestinal_ulcer0.91124488
67MP0005621_abnormal_cell_physiology0.90405578
68MP0001727_abnormal_embryo_implantation0.88723570
69MP0000490_abnormal_crypts_of0.88380257
70MP0002080_prenatal_lethality0.88320777
71MP0002085_abnormal_embryonic_tissue0.86844886
72MP0009672_abnormal_birth_weight0.85948678
73MP0001853_heart_inflammation0.83435269
74MP0009053_abnormal_anal_canal0.82171805
75MP0005410_abnormal_fertilization0.82075984
76MP0003937_abnormal_limbs/digits/tail_de0.81373390
77MP0008004_abnormal_stomach_pH0.80360349
78MP0000647_abnormal_sebaceous_gland0.79631688
79MP0000566_synostosis0.77935489
80MP0000427_abnormal_hair_cycle0.77361248
81MP0000367_abnormal_coat/_hair0.73759343
82MP0000358_abnormal_cell_content/0.73068203
83MP0005220_abnormal_exocrine_pancreas0.71525796
84MP0003936_abnormal_reproductive_system0.71105198
85MP0000470_abnormal_stomach_morphology0.70429792
86MP0004808_abnormal_hematopoietic_stem0.69536788
87MP0009931_abnormal_skin_appearance0.68940638
88MP0001348_abnormal_lacrimal_gland0.68315643
89MP0009703_decreased_birth_body0.66985038
90MP0005384_cellular_phenotype0.66524598
91MP0002396_abnormal_hematopoietic_system0.65783637
92MP0010030_abnormal_orbit_morphology0.65484749
93MP0005083_abnormal_biliary_tract0.64467524
94MP0005408_hypopigmentation0.64206166
95MP0002168_other_aberrant_phenotype0.63836326
96MP0000432_abnormal_head_morphology0.63815503
97MP0003806_abnormal_nucleotide_metabolis0.63560742
98MP0002697_abnormal_eye_size0.62215588
99MP0000733_abnormal_muscle_development0.60294487
100MP0004185_abnormal_adipocyte_glucose0.59929302

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)5.28463724
2Lip pit (HP:0100267)4.62676652
3Selective tooth agenesis (HP:0001592)3.30163057
4Popliteal pterygium (HP:0009756)3.12213210
5Onycholysis (HP:0001806)2.91253378
6Chronic bronchitis (HP:0004469)2.88197273
7Pili torti (HP:0003777)2.85879147
8Short nail (HP:0001799)2.85266818
9Hypoplastic labia majora (HP:0000059)2.78656352
10Chromsome breakage (HP:0040012)2.70257567
11Osteolytic defects of the phalanges of the hand (HP:0009771)2.69793148
12Osteolytic defects of the hand bones (HP:0009699)2.69793148
13Sparse lateral eyebrow (HP:0005338)2.67528962
14Abnormality of the labia majora (HP:0012881)2.65334898
15Sensory axonal neuropathy (HP:0003390)2.62946456
16Plantar hyperkeratosis (HP:0007556)2.62594626
17Congenital ichthyosiform erythroderma (HP:0007431)2.61051373
18Chromosomal breakage induced by crosslinking agents (HP:0003221)2.58231418
19Septate vagina (HP:0001153)2.49432233
20Thick nail (HP:0001805)2.47925771
21Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.46904517
22Sparse eyelashes (HP:0000653)2.46370852
23Palmoplantar hyperkeratosis (HP:0000972)2.43815834
24Abnormality of the distal phalanges of the toes (HP:0010182)2.43227984
25Abnormality of nail color (HP:0100643)2.41186750
26Curly hair (HP:0002212)2.37838943
27Palmar hyperkeratosis (HP:0010765)2.37063837
28Hypotrichosis (HP:0001006)2.36405759
29Pterygium (HP:0001059)2.33587749
30Natal tooth (HP:0000695)2.32111440
31Abnormality of the gastric mucosa (HP:0004295)2.29583235
32Facial cleft (HP:0002006)2.28529981
33Biliary tract neoplasm (HP:0100574)2.27894480
34Absent eyelashes (HP:0000561)2.27248644
35Ureteral duplication (HP:0000073)2.26091253
36Alopecia of scalp (HP:0002293)2.23597854
37Milia (HP:0001056)2.23008584
38Anal stenosis (HP:0002025)2.21601755
39Central scotoma (HP:0000603)2.13248283
40Tetraparesis (HP:0002273)2.09467947
41Trismus (HP:0000211)2.09359937
42Abnormal hair laboratory examination (HP:0003328)2.08799503
43Duplicated collecting system (HP:0000081)2.08798253
44Ankyloglossia (HP:0010296)2.06881778
45Abnormality of the salivary glands (HP:0010286)2.06760329
46Exocrine pancreatic insufficiency (HP:0001738)2.03601282
47Abnormality of permanent molar morphology (HP:0011071)2.00827918
48Abnormality of the dental root (HP:0006486)2.00827918
49Taurodontia (HP:0000679)2.00827918
50Ileus (HP:0002595)2.00806341
51Vascular calcification (HP:0004934)2.00686307
52Deep philtrum (HP:0002002)2.00666173
53Abnormality of the nasal septum (HP:0000419)1.98160738
54Malnutrition (HP:0004395)1.97321168
55Hyperactive renin-angiotensin system (HP:0000841)1.93706888
56Fragile nails (HP:0001808)1.93384548
57Ectropion (HP:0000656)1.92539609
58Cardiovascular calcification (HP:0011915)1.90398989
59Abnormal respiratory motile cilium physiology (HP:0012261)1.90243134
60Ventricular tachycardia (HP:0004756)1.89719177
61Clubbing of toes (HP:0100760)1.87891596
62Scotoma (HP:0000575)1.87806234
63Woolly hair (HP:0002224)1.87112139
64Subcapsular cataract (HP:0000523)1.87006629
65Male infertility (HP:0003251)1.86695996
66Rhinitis (HP:0012384)1.86670812
67Steatorrhea (HP:0002570)1.86635460
68Arterial tortuosity (HP:0005116)1.86615315
69Hypoplasia of dental enamel (HP:0006297)1.86377270
70Abnormality of the dental pulp (HP:0006479)1.85488462
71Abnormal biliary tract morphology (HP:0012440)1.83407767
72Amniotic constriction ring (HP:0009775)1.83398011
73Abnormality of placental membranes (HP:0011409)1.83398011
74Atrophic scars (HP:0001075)1.83056676
75Papillary thyroid carcinoma (HP:0002895)1.81545032
76Nail dystrophy (HP:0008404)1.80943756
77Cone-rod dystrophy (HP:0000548)1.80206202
78Micronodular cirrhosis (HP:0001413)1.79803904
79Abnormality of molar morphology (HP:0011070)1.79528781
80Abnormality of molar (HP:0011077)1.79528781
81Corneal erosion (HP:0200020)1.79078492
82Wide intermamillary distance (HP:0006610)1.77819891
83Abnormality of the renal collecting system (HP:0004742)1.77077037
84Abnormality of the preputium (HP:0100587)1.76026025
85Bronchiectasis (HP:0002110)1.75942115
86Abnormalities of placenta or umbilical cord (HP:0001194)1.75335550
87Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.73172930
88Ridged nail (HP:0001807)1.71999318
89Abnormality of methionine metabolism (HP:0010901)1.71630622
90Flat acetabular roof (HP:0003180)1.69883449
91Intrahepatic cholestasis (HP:0001406)1.69461212
92Abnormal pancreas size (HP:0012094)1.68462455
93Advanced eruption of teeth (HP:0006288)1.68290740
94Hyperkalemia (HP:0002153)1.67974898
95Abnormality of small intestinal villus morphology (HP:0011472)1.67724747
96Villous atrophy (HP:0011473)1.67724747
97Aplasia cutis congenita (HP:0001057)1.67482393
98Cubitus valgus (HP:0002967)1.66527153
99Abnormality of the umbilical cord (HP:0010881)1.66159040
100Deviation of the thumb (HP:0009603)1.65181289

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.98542392
2MST44.53005027
3EPHA24.10173778
4STK243.51405600
5MAP3K122.69417538
6EIF2AK32.68176119
7MET2.48146365
8PBK2.45097952
9BUB12.24802574
10BRSK22.02856365
11STK38L1.95534784
12TTK1.87694586
13TSSK61.72627982
14CDK121.72062659
15STK391.71656189
16TRIM281.71332413
17PAK41.66431698
18MYLK1.61413975
19SRPK11.59632783
20LMTK21.58390238
21NME11.53103145
22LATS11.45634488
23TRPM71.44225329
24EIF2AK11.44163373
25WEE11.42189171
26BCR1.38069975
27MAP3K21.34843196
28PTK21.33191655
29AKT31.32142518
30MKNK21.24673566
31BMPR1B1.23609844
32CDK81.22335198
33SIK31.22159592
34MELK1.20129614
35NEK11.19772574
36STK31.17590172
37TNIK1.14323774
38LATS21.14222809
39MAP3K31.08969579
40IRAK31.07904356
41RPS6KB21.06553275
42ILK1.05474677
43ERBB41.05077228
44FER1.04091427
45EEF2K0.99332869
46FGFR10.95591767
47PLK40.90450384
48MAP3K90.88538127
49PDK20.87963172
50STK100.86070859
51BRD40.85822032
52NME20.83190590
53ACVR1B0.80533022
54SCYL20.74209368
55PRKCI0.70996186
56BMX0.70370609
57MAPKAPK30.70207259
58FRK0.70179987
59PLK10.65802175
60CDC70.65565033
61PLK30.64694281
62ZAK0.64606151
63MTOR0.64307494
64CDK70.61257503
65CHEK20.60629840
66OXSR10.59836831
67TGFBR10.57756407
68PIK3CA0.56855138
69MKNK10.55066825
70AURKB0.54360013
71CHEK10.53616220
72PKN20.53431471
73CHUK0.51944214
74DMPK0.51816903
75ERBB30.51162223
76STK380.50778643
77EIF2AK20.50030716
78TESK10.49773689
79MAP3K80.49768237
80MAP3K100.48380881
81AKT20.48253710
82MAP3K140.47597787
83CDK90.47399406
84NEK60.45140410
85BRSK10.43703394
86PDGFRA0.42278594
87PIM20.39631248
88STK160.39518892
89PRKG20.35648690
90BRAF0.35037749
91PNCK0.32842392
92NEK90.32614177
93ATM0.30189025
94MAP3K70.30179007
95WNK40.26330883
96WNK10.26229778
97STK40.25420995
98IKBKB0.24630030
99CDK60.24611157
100PAK20.24563249

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.42882980
2Proteasome_Homo sapiens_hsa030502.36450548
3Adherens junction_Homo sapiens_hsa045202.34172008
4Pancreatic secretion_Homo sapiens_hsa049722.24259350
5Non-homologous end-joining_Homo sapiens_hsa034502.24145951
6DNA replication_Homo sapiens_hsa030302.10473604
7Thyroid cancer_Homo sapiens_hsa052162.02699812
8Cell cycle_Homo sapiens_hsa041102.02511073
9Mismatch repair_Homo sapiens_hsa034301.98379583
10Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.94621917
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.90820757
12RNA transport_Homo sapiens_hsa030131.90228730
13Small cell lung cancer_Homo sapiens_hsa052221.81958285
14p53 signaling pathway_Homo sapiens_hsa041151.79707703
15Sulfur metabolism_Homo sapiens_hsa009201.73145937
16Tight junction_Homo sapiens_hsa045301.64546433
17ECM-receptor interaction_Homo sapiens_hsa045121.59263429
18RNA polymerase_Homo sapiens_hsa030201.55804746
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.52044944
20Vitamin digestion and absorption_Homo sapiens_hsa049771.49525025
21Sphingolipid metabolism_Homo sapiens_hsa006001.49340120
22Homologous recombination_Homo sapiens_hsa034401.45865879
23Protein digestion and absorption_Homo sapiens_hsa049741.45798509
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.44605130
25N-Glycan biosynthesis_Homo sapiens_hsa005101.38021082
26One carbon pool by folate_Homo sapiens_hsa006701.37271829
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.35248767
28TGF-beta signaling pathway_Homo sapiens_hsa043501.34815236
29Nucleotide excision repair_Homo sapiens_hsa034201.33833108
30Fat digestion and absorption_Homo sapiens_hsa049751.32260391
31Pyrimidine metabolism_Homo sapiens_hsa002401.32120513
32Selenocompound metabolism_Homo sapiens_hsa004501.27322664
33Circadian rhythm_Homo sapiens_hsa047101.27292310
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.25768116
35Prostate cancer_Homo sapiens_hsa052151.21629309
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.20319763
37Hippo signaling pathway_Homo sapiens_hsa043901.19161695
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17793340
39Basal transcription factors_Homo sapiens_hsa030221.15405079
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14821443
41Proteoglycans in cancer_Homo sapiens_hsa052051.08684020
42mRNA surveillance pathway_Homo sapiens_hsa030151.08628083
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.06573309
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03648801
45Vitamin B6 metabolism_Homo sapiens_hsa007501.00762874
46Bladder cancer_Homo sapiens_hsa052190.99980015
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98078146
48Glutathione metabolism_Homo sapiens_hsa004800.97186365
49Focal adhesion_Homo sapiens_hsa045100.96224916
50Hepatitis C_Homo sapiens_hsa051600.92930027
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92090198
52MicroRNAs in cancer_Homo sapiens_hsa052060.92026294
53Starch and sucrose metabolism_Homo sapiens_hsa005000.89607777
54Base excision repair_Homo sapiens_hsa034100.86119726
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85402337
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.82177513
57Galactose metabolism_Homo sapiens_hsa000520.75848496
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.74173864
59RNA degradation_Homo sapiens_hsa030180.73855946
60Viral carcinogenesis_Homo sapiens_hsa052030.73395593
61Lysine degradation_Homo sapiens_hsa003100.72795584
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.72598272
63Pancreatic cancer_Homo sapiens_hsa052120.72509558
64Folate biosynthesis_Homo sapiens_hsa007900.70586807
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69902267
66Glycerolipid metabolism_Homo sapiens_hsa005610.69249588
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69006627
68TNF signaling pathway_Homo sapiens_hsa046680.67250105
69Spliceosome_Homo sapiens_hsa030400.67003072
70Oocyte meiosis_Homo sapiens_hsa041140.66417033
71Renal cell carcinoma_Homo sapiens_hsa052110.66117271
72Renin-angiotensin system_Homo sapiens_hsa046140.65309243
73Protein export_Homo sapiens_hsa030600.64511677
74Fructose and mannose metabolism_Homo sapiens_hsa000510.63168376
75Fanconi anemia pathway_Homo sapiens_hsa034600.61473797
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61160756
77Chronic myeloid leukemia_Homo sapiens_hsa052200.57945839
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.57598943
79Purine metabolism_Homo sapiens_hsa002300.57105086
80Apoptosis_Homo sapiens_hsa042100.56282641
81Steroid biosynthesis_Homo sapiens_hsa001000.56043352
82Pathways in cancer_Homo sapiens_hsa052000.53608284
83Biosynthesis of amino acids_Homo sapiens_hsa012300.53155854
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52889644
85Retinol metabolism_Homo sapiens_hsa008300.52865808
86Inositol phosphate metabolism_Homo sapiens_hsa005620.52565135
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52373098
88Pyruvate metabolism_Homo sapiens_hsa006200.51298248
89Epstein-Barr virus infection_Homo sapiens_hsa051690.51161422
90Arginine and proline metabolism_Homo sapiens_hsa003300.51025015
91Influenza A_Homo sapiens_hsa051640.50141407
92Shigellosis_Homo sapiens_hsa051310.46846591
93Melanoma_Homo sapiens_hsa052180.44117993
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43113992
95Vibrio cholerae infection_Homo sapiens_hsa051100.42296320
96Legionellosis_Homo sapiens_hsa051340.40966257
97Chemical carcinogenesis_Homo sapiens_hsa052040.40374377
98Phenylalanine metabolism_Homo sapiens_hsa003600.40214253
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39202351
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37509496

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