C3ORF49

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)6.58911074
2replication fork processing (GO:0031297)3.91892151
3piRNA metabolic process (GO:0034587)3.85569449
4respiratory chain complex IV assembly (GO:0008535)3.74195640
5protein polyglutamylation (GO:0018095)3.66453397
6inositol phosphate catabolic process (GO:0071545)3.62729277
7DNA methylation involved in gamete generation (GO:0043046)3.54786662
8synapsis (GO:0007129)3.50887437
9L-fucose catabolic process (GO:0042355)3.46813071
10fucose catabolic process (GO:0019317)3.46813071
11L-fucose metabolic process (GO:0042354)3.46813071
12resolution of meiotic recombination intermediates (GO:0000712)3.44699992
13regulation of meiosis I (GO:0060631)3.41864569
14protein K11-linked deubiquitination (GO:0035871)3.38566921
15male meiosis (GO:0007140)3.35918352
16axoneme assembly (GO:0035082)3.33137270
17epithelial cilium movement (GO:0003351)3.33073059
18cytochrome complex assembly (GO:0017004)3.28893541
19phosphorylated carbohydrate dephosphorylation (GO:0046838)3.27338346
20inositol phosphate dephosphorylation (GO:0046855)3.27338346
21DNA deamination (GO:0045006)3.25258776
22cullin deneddylation (GO:0010388)3.25236654
23DNA double-strand break processing (GO:0000729)3.25106577
24water-soluble vitamin biosynthetic process (GO:0042364)3.23469850
25somatic hypermutation of immunoglobulin genes (GO:0016446)3.22201713
26somatic diversification of immune receptors via somatic mutation (GO:0002566)3.22201713
27epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.14785851
28regulation of cilium movement (GO:0003352)3.12864889
29regulation of hexokinase activity (GO:1903299)3.08322553
30regulation of glucokinase activity (GO:0033131)3.08322553
31polyol catabolic process (GO:0046174)3.07679461
32behavioral response to ethanol (GO:0048149)3.03931934
33maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.01752168
34adaptation of signaling pathway (GO:0023058)3.01032933
35neural tube formation (GO:0001841)3.00368633
36protein deneddylation (GO:0000338)2.97137796
37protein complex biogenesis (GO:0070271)2.94380431
38pyrimidine nucleobase catabolic process (GO:0006208)2.85192905
39behavioral response to nicotine (GO:0035095)2.84338207
40nucleotide transmembrane transport (GO:1901679)2.84117719
41RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.83598174
42detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.83301391
43negative regulation of DNA-dependent DNA replication (GO:2000104)2.83037784
44proteasome assembly (GO:0043248)2.82942888
45positive regulation of mitochondrial fission (GO:0090141)2.80159931
46limb bud formation (GO:0060174)2.79027924
47mitochondrial respiratory chain complex assembly (GO:0033108)2.77713930
48platelet dense granule organization (GO:0060155)2.74350271
49nucleobase catabolic process (GO:0046113)2.70991555
50proline transport (GO:0015824)2.70965622
51preassembly of GPI anchor in ER membrane (GO:0016254)2.69360721
52mannosylation (GO:0097502)2.69183430
53nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.67738533
54exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.67519070
55mitochondrial respiratory chain complex I assembly (GO:0032981)2.66605196
56NADH dehydrogenase complex assembly (GO:0010257)2.66605196
57mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.66605196
58male meiosis I (GO:0007141)2.65910452
59histone H2A acetylation (GO:0043968)2.64578573
60protein K6-linked ubiquitination (GO:0085020)2.63541470
61sperm motility (GO:0030317)2.62398404
62cilium morphogenesis (GO:0060271)2.58665330
63cilium movement (GO:0003341)2.57784081
64cornea development in camera-type eye (GO:0061303)2.57726909
65recombinational repair (GO:0000725)2.56700520
66double-strand break repair via homologous recombination (GO:0000724)2.55741979
67protein prenylation (GO:0018342)2.54991766
68prenylation (GO:0097354)2.54991766
69glycosphingolipid biosynthetic process (GO:0006688)2.53534296
70regulation of nuclear cell cycle DNA replication (GO:0033262)2.51357661
71intraciliary transport (GO:0042073)2.51002032
72reciprocal DNA recombination (GO:0035825)2.49882528
73reciprocal meiotic recombination (GO:0007131)2.49882528
74cilium organization (GO:0044782)2.49853190
75detection of light stimulus involved in visual perception (GO:0050908)2.49534781
76detection of light stimulus involved in sensory perception (GO:0050962)2.49534781
77regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.49444168
78protein localization to cilium (GO:0061512)2.48074689
79S-adenosylmethionine metabolic process (GO:0046500)2.47993040
80cilium assembly (GO:0042384)2.47596152
81photoreceptor cell maintenance (GO:0045494)2.46303749
82somite development (GO:0061053)2.45569444
83ketone body metabolic process (GO:1902224)2.44836281
84kynurenine metabolic process (GO:0070189)2.44103496
85cellular ketone body metabolic process (GO:0046950)2.42058831
86tryptophan catabolic process (GO:0006569)2.41171204
87indole-containing compound catabolic process (GO:0042436)2.41171204
88indolalkylamine catabolic process (GO:0046218)2.41171204
89indolalkylamine metabolic process (GO:0006586)2.39052349
90multicellular organism reproduction (GO:0032504)2.38558482
91single strand break repair (GO:0000012)2.38392251
92pseudouridine synthesis (GO:0001522)2.38263773
93seminiferous tubule development (GO:0072520)2.37983125
94negative regulation of dendrite development (GO:2000171)2.37623354
95sympathetic nervous system development (GO:0048485)2.36010788
96retinal cone cell development (GO:0046549)2.35235060
97negative regulation of telomere maintenance (GO:0032205)2.35161200
98establishment of protein localization to mitochondrial membrane (GO:0090151)2.33855147
99centriole replication (GO:0007099)2.32937473
100anterograde synaptic vesicle transport (GO:0048490)2.32853922

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.44276918
2VDR_22108803_ChIP-Seq_LS180_Human3.26135169
3GBX2_23144817_ChIP-Seq_PC3_Human3.17957377
4IGF1R_20145208_ChIP-Seq_DFB_Human2.80844377
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.79179352
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.73548323
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.71023148
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.55786498
9TAF15_26573619_Chip-Seq_HEK293_Human2.34148109
10FUS_26573619_Chip-Seq_HEK293_Human2.30530140
11EWS_26573619_Chip-Seq_HEK293_Human2.24529356
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.23322572
13P300_19829295_ChIP-Seq_ESCs_Human2.17402444
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14376096
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.09607202
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.02972926
17GABP_17652178_ChIP-ChIP_JURKAT_Human1.95109773
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94416308
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.90573747
20EST1_17652178_ChIP-ChIP_JURKAT_Human1.85963201
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83428614
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81960241
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.81134138
24* ER_23166858_ChIP-Seq_MCF-7_Human1.80540592
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79621040
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76812875
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73174676
28* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.71356128
29* CBP_20019798_ChIP-Seq_JUKART_Human1.71356128
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.64683136
31* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62755504
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62021080
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.60435694
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57163251
35SMAD4_21799915_ChIP-Seq_A2780_Human1.56720950
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55228278
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53402389
38STAT3_23295773_ChIP-Seq_U87_Human1.50035038
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49763506
40AR_25329375_ChIP-Seq_VCAP_Human1.47495373
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.46643944
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46206109
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.45639792
44TCF4_23295773_ChIP-Seq_U87_Human1.44188994
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43721282
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43320476
47KLF5_20875108_ChIP-Seq_MESCs_Mouse1.43280122
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43060838
49BCAT_22108803_ChIP-Seq_LS180_Human1.41847609
50* NANOG_19829295_ChIP-Seq_ESCs_Human1.41733579
51* SOX2_19829295_ChIP-Seq_ESCs_Human1.41733579
52ELK1_19687146_ChIP-ChIP_HELA_Human1.40577599
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.39413327
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37756359
55IRF1_19129219_ChIP-ChIP_H3396_Human1.35450779
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.35432800
57EZH2_22144423_ChIP-Seq_EOC_Human1.35234960
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33579660
59TCF4_22108803_ChIP-Seq_LS180_Human1.33347460
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.33031257
61TP53_22573176_ChIP-Seq_HFKS_Human1.32067265
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31983614
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31591201
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30605588
65MYC_18940864_ChIP-ChIP_HL60_Human1.29617354
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28491093
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28267122
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23413535
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21876443
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21805852
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21805852
72P53_22387025_ChIP-Seq_ESCs_Mouse1.21635108
73VDR_23849224_ChIP-Seq_CD4+_Human1.20039122
74CDX2_22108803_ChIP-Seq_LS180_Human1.18831460
75TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17739424
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.17705197
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17353205
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17333857
79RUNX2_22187159_ChIP-Seq_PCA_Human1.16044288
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.14489207
81FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13830918
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13254933
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.12353425
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11827969
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.10749460
86E2F1_18555785_Chip-Seq_ESCs_Mouse1.09030598
87SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08232153
88FOXA1_25329375_ChIP-Seq_VCAP_Human1.08168768
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08168768
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06633308
91PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05908888
92STAT3_18555785_Chip-Seq_ESCs_Mouse1.05785070
93P300_18555785_Chip-Seq_ESCs_Mouse1.05293417
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.04575070
95* NCOR_22424771_ChIP-Seq_293T_Human1.01839175
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.01757713
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00754591
98OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99119204
99RNF2_27304074_Chip-Seq_NSC_Mouse0.98325002
100HOXB7_26014856_ChIP-Seq_BT474_Human0.97939460

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.98333001
2MP0000372_irregular_coat_pigmentation2.98069259
3MP0003787_abnormal_imprinting2.71158899
4MP0002102_abnormal_ear_morphology2.51499930
5MP0003195_calcinosis2.49858920
6MP0001529_abnormal_vocalization2.32537538
7MP0003880_abnormal_central_pattern2.24648075
8MP0008058_abnormal_DNA_repair2.21013544
9MP0001984_abnormal_olfaction2.15314352
10MP0005551_abnormal_eye_electrophysiolog2.12998276
11MP0001968_abnormal_touch/_nociception2.04135284
12MP0005253_abnormal_eye_physiology1.99575518
13MP0004147_increased_porphyrin_level1.98134114
14MP0003718_maternal_effect1.94248989
15MP0005646_abnormal_pituitary_gland1.94175380
16MP0006276_abnormal_autonomic_nervous1.87094752
17MP0000427_abnormal_hair_cycle1.85908386
18MP0005645_abnormal_hypothalamus_physiol1.81872951
19MP0003121_genomic_imprinting1.79882468
20MP0006292_abnormal_olfactory_placode1.74286912
21MP0002234_abnormal_pharynx_morphology1.69306556
22MP0009046_muscle_twitch1.64686843
23MP0002736_abnormal_nociception_after1.64582563
24MP0006072_abnormal_retinal_apoptosis1.63739921
25MP0003646_muscle_fatigue1.63343116
26MP0005075_abnormal_melanosome_morpholog1.60427953
27MP0008875_abnormal_xenobiotic_pharmacok1.60396017
28MP0005084_abnormal_gallbladder_morpholo1.59273596
29MP0008872_abnormal_physiological_respon1.55906646
30MP0001486_abnormal_startle_reflex1.51667640
31MP0000631_abnormal_neuroendocrine_gland1.50101642
32MP0002638_abnormal_pupillary_reflex1.48883747
33MP0005410_abnormal_fertilization1.48425440
34MP0009745_abnormal_behavioral_response1.43362527
35MP0002938_white_spotting1.43223261
36MP0002751_abnormal_autonomic_nervous1.42844602
37MP0008789_abnormal_olfactory_epithelium1.42258129
38MP0001764_abnormal_homeostasis1.41935606
39MP0002272_abnormal_nervous_system1.40920142
40MP0008057_abnormal_DNA_replication1.33241111
41MP0003136_yellow_coat_color1.31683936
42MP0003122_maternal_imprinting1.30431269
43MP0006035_abnormal_mitochondrial_morpho1.30206880
44MP0001485_abnormal_pinna_reflex1.29003070
45MP0010094_abnormal_chromosome_stability1.26871910
46MP0003011_delayed_dark_adaptation1.24778165
47MP0000383_abnormal_hair_follicle1.23552548
48MP0005171_absent_coat_pigmentation1.22181123
49MP0001929_abnormal_gametogenesis1.20841006
50MP0003698_abnormal_male_reproductive1.17012571
51MP0002876_abnormal_thyroid_physiology1.15999918
52MP0004133_heterotaxia1.14444617
53MP0002160_abnormal_reproductive_system1.12197381
54MP0000015_abnormal_ear_pigmentation1.11199901
55MP0004142_abnormal_muscle_tone1.10957280
56MP0006036_abnormal_mitochondrial_physio1.07178150
57MP0005647_abnormal_sex_gland1.05469514
58MP0002095_abnormal_skin_pigmentation1.05434776
59MP0004215_abnormal_myocardial_fiber1.05137963
60MP0004885_abnormal_endolymph1.03490645
61MP0000778_abnormal_nervous_system1.03167193
62MP0005174_abnormal_tail_pigmentation1.02603420
63MP0004924_abnormal_behavior1.02257713
64MP0005386_behavior/neurological_phenoty1.02257713
65MP0002837_dystrophic_cardiac_calcinosis1.02081986
66MP0002210_abnormal_sex_determination1.01569321
67MP0000569_abnormal_digit_pigmentation1.00759126
68MP0004484_altered_response_of1.00396972
69MP0010678_abnormal_skin_adnexa0.99351583
70MP0001188_hyperpigmentation0.99243963
71MP0002067_abnormal_sensory_capabilities0.97669677
72MP0005394_taste/olfaction_phenotype0.96823343
73MP0005499_abnormal_olfactory_system0.96823343
74MP0002229_neurodegeneration0.96733975
75MP0010386_abnormal_urinary_bladder0.96399329
76MP0004043_abnormal_pH_regulation0.95201906
77MP0002572_abnormal_emotion/affect_behav0.94618649
78MP0001293_anophthalmia0.94431252
79MP0002557_abnormal_social/conspecific_i0.93530566
80MP0005389_reproductive_system_phenotype0.93055264
81MP0008995_early_reproductive_senescence0.92874978
82MP0002064_seizures0.91975166
83MP0003786_premature_aging0.91655552
84MP0000653_abnormal_sex_gland0.91345713
85MP0001986_abnormal_taste_sensitivity0.91191455
86MP0004270_analgesia0.90930963
87MP0001324_abnormal_eye_pigmentation0.90503732
88MP0005395_other_phenotype0.88620236
89MP0000647_abnormal_sebaceous_gland0.87462628
90MP0001145_abnormal_male_reproductive0.86456162
91MP0002184_abnormal_innervation0.85634636
92MP0002752_abnormal_somatic_nervous0.84183239
93MP0009697_abnormal_copulation0.84174656
94MP0003635_abnormal_synaptic_transmissio0.83270412
95MP0005195_abnormal_posterior_eye0.82380569
96MP0002734_abnormal_mechanical_nocicepti0.80877823
97MP0002282_abnormal_trachea_morphology0.80208446
98MP0005391_vision/eye_phenotype0.79309723
99MP0003186_abnormal_redox_activity0.77136154
100MP0002909_abnormal_adrenal_gland0.75455675

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.89145405
2Pancreatic fibrosis (HP:0100732)3.76474824
3True hermaphroditism (HP:0010459)3.61623166
4Abnormality of midbrain morphology (HP:0002418)3.46786934
5Molar tooth sign on MRI (HP:0002419)3.46786934
6Medial flaring of the eyebrow (HP:0010747)3.06869974
7Nephronophthisis (HP:0000090)3.03637284
8Attenuation of retinal blood vessels (HP:0007843)3.02128890
9Abnormality of the labia minora (HP:0012880)2.99822392
10Abnormal rod and cone electroretinograms (HP:0008323)2.85553306
11Type II lissencephaly (HP:0007260)2.81413727
12Abnormality of the renal cortex (HP:0011035)2.81183162
13Congenital stationary night blindness (HP:0007642)2.79358209
14Dynein arm defect of respiratory motile cilia (HP:0012255)2.70776188
15Absent/shortened dynein arms (HP:0200106)2.70776188
16Chronic hepatic failure (HP:0100626)2.69176727
17Intestinal atresia (HP:0011100)2.66108493
18Abnormality of the renal medulla (HP:0100957)2.64035595
19Gaze-evoked nystagmus (HP:0000640)2.56295989
20Atonic seizures (HP:0010819)2.54983655
21Congenital primary aphakia (HP:0007707)2.54383032
22Gait imbalance (HP:0002141)2.54123649
23Abnormal biliary tract physiology (HP:0012439)2.52246072
24Bile duct proliferation (HP:0001408)2.52246072
25Hypothermia (HP:0002045)2.49883697
26Ependymoma (HP:0002888)2.46634640
27Renal cortical cysts (HP:0000803)2.45077147
28Abnormality of macular pigmentation (HP:0008002)2.44764062
29Nephrogenic diabetes insipidus (HP:0009806)2.40442811
30Cystic liver disease (HP:0006706)2.38641750
31Genital tract atresia (HP:0001827)2.38537451
32Abolished electroretinogram (ERG) (HP:0000550)2.32532417
33Aplasia/Hypoplasia of the tongue (HP:0010295)2.27090115
34Cerebellar dysplasia (HP:0007033)2.26889413
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.26758892
36Pendular nystagmus (HP:0012043)2.24720435
37Lissencephaly (HP:0001339)2.13677606
38Vaginal atresia (HP:0000148)2.13104229
39Broad-based gait (HP:0002136)2.11860644
40Acute encephalopathy (HP:0006846)2.10937244
41Astrocytoma (HP:0009592)2.10899696
42Abnormality of the astrocytes (HP:0100707)2.10899696
43Dyschromatopsia (HP:0007641)2.10695525
44Poor coordination (HP:0002370)2.08447554
45Tubular atrophy (HP:0000092)2.06083269
46Sensory axonal neuropathy (HP:0003390)2.05309580
47Febrile seizures (HP:0002373)2.04922818
48Acute necrotizing encephalopathy (HP:0006965)2.04392383
49Polydipsia (HP:0001959)2.03286154
50Abnormal drinking behavior (HP:0030082)2.03286154
51Type 2 muscle fiber atrophy (HP:0003554)2.02607703
52Progressive macrocephaly (HP:0004481)2.01088689
53Tubulointerstitial nephritis (HP:0001970)1.99634766
54Abnormality of the fovea (HP:0000493)1.99273763
55Progressive inability to walk (HP:0002505)1.99234958
56Hypoproteinemia (HP:0003075)1.99084905
57Sclerocornea (HP:0000647)1.97797543
58Methylmalonic acidemia (HP:0002912)1.97761926
59Glioma (HP:0009733)1.97125808
60Disproportionate short-trunk short stature (HP:0003521)1.96400208
61Abnormality of chromosome stability (HP:0003220)1.96012156
62Increased CSF lactate (HP:0002490)1.95733716
63Anencephaly (HP:0002323)1.95584608
64Aplasia/Hypoplasia of the uvula (HP:0010293)1.94714618
65Dialeptic seizures (HP:0011146)1.94227703
66Aplasia/Hypoplasia of the tibia (HP:0005772)1.94066378
67Mitochondrial inheritance (HP:0001427)1.92024872
68Progressive cerebellar ataxia (HP:0002073)1.91332687
69Abnormality of the ileum (HP:0001549)1.89715092
70Volvulus (HP:0002580)1.89287970
71Abnormal respiratory motile cilium morphology (HP:0005938)1.88227168
72Abnormal respiratory epithelium morphology (HP:0012253)1.88227168
73Meckel diverticulum (HP:0002245)1.86975784
74Constricted visual fields (HP:0001133)1.86204784
75Chorioretinal atrophy (HP:0000533)1.85220739
76Postaxial hand polydactyly (HP:0001162)1.85193261
77Hypoplasia of the fovea (HP:0007750)1.81960068
78Aplasia/Hypoplasia of the fovea (HP:0008060)1.81960068
79Pachygyria (HP:0001302)1.81787531
80Polyuria (HP:0000103)1.81485670
81Bony spicule pigmentary retinopathy (HP:0007737)1.80902341
82Decreased central vision (HP:0007663)1.79826765
83Focal seizures (HP:0007359)1.79350524
84Neoplasm of the adrenal cortex (HP:0100641)1.79042347
85Abnormality of aspartate family amino acid metabolism (HP:0010899)1.78941138
86Inability to walk (HP:0002540)1.78888649
87Short tibia (HP:0005736)1.78825281
88Colon cancer (HP:0003003)1.77253625
89Abnormality of vitamin B metabolism (HP:0004340)1.76926392
90Male pseudohermaphroditism (HP:0000037)1.76910232
91Postaxial foot polydactyly (HP:0001830)1.75572466
92Supernumerary spleens (HP:0009799)1.74325091
93Hypomagnesemia (HP:0002917)1.73681406
943-Methylglutaconic aciduria (HP:0003535)1.73329665
95Type I transferrin isoform profile (HP:0003642)1.73251528
96Astigmatism (HP:0000483)1.73167960
97Congenital hepatic fibrosis (HP:0002612)1.72946624
98Clubbing of toes (HP:0100760)1.71881706
99Abnormal ciliary motility (HP:0012262)1.71520843
100Sloping forehead (HP:0000340)1.70716540

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.30353116
2TRIM283.66470524
3WNK33.14493991
4PINK12.64335232
5MAP4K22.60300898
6BCR2.57605615
7NUAK12.49908138
8EIF2AK32.48049790
9BMPR1B2.44572401
10INSRR2.29446303
11EIF2AK12.24037308
12ADRBK22.04809622
13ERBB31.99330815
14MST41.79154191
15TNIK1.75109047
16MAP3K41.62071062
17ZAK1.59485391
18GRK11.55331786
19MAPK131.55003608
20STK391.54582192
21MKNK21.47703694
22ACVR1B1.47022294
23OXSR11.42777193
24PLK31.41792357
25TAOK31.40940977
26SIK31.40776693
27PLK21.30824960
28CSNK1G11.30387445
29CSNK1G31.28585602
30EPHA41.28251122
31MKNK11.26833376
32CSNK1G21.24897811
33CSNK1A1L1.15607092
34TSSK61.13597446
35STK38L1.12339034
36PAK31.09815213
37BRSK21.07453388
38VRK11.07376185
39VRK21.03460809
40MAP2K71.02782417
41PBK1.02379767
42SRPK10.95253658
43AKT30.92118679
44STK160.91546194
45MARK10.90632387
46FGFR20.89133443
47MAP3K120.87659200
48MINK10.86681259
49MUSK0.84305941
50DYRK20.82948282
51TAF10.82405017
52CASK0.80875729
53PRKCE0.80446306
54PLK40.80330155
55FER0.79554631
56STK30.76188023
57WNK40.74907348
58NTRK30.72445371
59TGFBR10.72196675
60NEK10.71005909
61EIF2AK20.70889014
62TIE10.67354674
63IRAK10.66933513
64PIK3CG0.63701845
65TXK0.63172010
66PIK3CA0.62552578
67TGFBR20.60707208
68PRKCG0.58731677
69TEC0.57270747
70BUB10.54241769
71ADRBK10.53811144
72BCKDK0.53543614
73CAMK2A0.53395436
74ATM0.53053155
75PLK10.49097923
76MARK30.48362797
77PRKCI0.48221186
78GRK50.46462058
79CSNK1A10.44887764
80ATR0.44017818
81DAPK10.43283750
82WEE10.42964159
83PDK20.42593690
84TNK20.42557202
85CAMKK20.40376970
86PHKG10.40232521
87PHKG20.40232521
88STK240.39383521
89OBSCN0.38948610
90BRD40.38189151
91KSR10.35441174
92PRKG10.34627962
93ABL10.34109753
94DYRK1A0.31850373
95CSNK1D0.31214974
96PRKACA0.31085776
97DYRK30.30899845
98IGF1R0.30453547
99RPS6KA40.28587369
100NTRK20.28495348

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.94832188
2Caffeine metabolism_Homo sapiens_hsa002322.64920314
3Non-homologous end-joining_Homo sapiens_hsa034502.63014452
4Phototransduction_Homo sapiens_hsa047442.58138863
5Selenocompound metabolism_Homo sapiens_hsa004502.47194067
6Butanoate metabolism_Homo sapiens_hsa006502.32796146
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.31588765
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.28230407
9Propanoate metabolism_Homo sapiens_hsa006402.26424596
10Protein export_Homo sapiens_hsa030602.19439915
11Basal transcription factors_Homo sapiens_hsa030222.14267738
12Fanconi anemia pathway_Homo sapiens_hsa034602.12642489
13Homologous recombination_Homo sapiens_hsa034402.06999822
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.02717911
15Proteasome_Homo sapiens_hsa030501.98309702
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.96338830
17RNA polymerase_Homo sapiens_hsa030201.91478679
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79181526
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78004798
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.66245013
21Nicotine addiction_Homo sapiens_hsa050331.65365768
22RNA degradation_Homo sapiens_hsa030181.63408939
23Linoleic acid metabolism_Homo sapiens_hsa005911.61496834
24Ether lipid metabolism_Homo sapiens_hsa005651.60417550
25Nitrogen metabolism_Homo sapiens_hsa009101.58588012
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47257624
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.45599589
28Oxidative phosphorylation_Homo sapiens_hsa001901.41418663
29Olfactory transduction_Homo sapiens_hsa047401.38806997
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34836423
31One carbon pool by folate_Homo sapiens_hsa006701.32554518
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27759811
33Sulfur metabolism_Homo sapiens_hsa009201.23690141
34Fatty acid elongation_Homo sapiens_hsa000621.22511424
35Regulation of autophagy_Homo sapiens_hsa041401.18612695
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.18343041
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.15302270
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12183896
39Taste transduction_Homo sapiens_hsa047421.10824448
40Steroid biosynthesis_Homo sapiens_hsa001001.09604660
41RNA transport_Homo sapiens_hsa030131.08231538
42Peroxisome_Homo sapiens_hsa041461.06017366
43Parkinsons disease_Homo sapiens_hsa050121.05670245
44Tryptophan metabolism_Homo sapiens_hsa003801.02899371
45Collecting duct acid secretion_Homo sapiens_hsa049661.01814102
46GABAergic synapse_Homo sapiens_hsa047270.99618424
47Mismatch repair_Homo sapiens_hsa034300.96839642
48Purine metabolism_Homo sapiens_hsa002300.95823100
49Morphine addiction_Homo sapiens_hsa050320.95431298
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89282940
51Salivary secretion_Homo sapiens_hsa049700.88215678
52ABC transporters_Homo sapiens_hsa020100.86147894
53Insulin secretion_Homo sapiens_hsa049110.83603678
54Circadian rhythm_Homo sapiens_hsa047100.83101504
55Vitamin B6 metabolism_Homo sapiens_hsa007500.80695540
56Circadian entrainment_Homo sapiens_hsa047130.79971745
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79909795
58Huntingtons disease_Homo sapiens_hsa050160.77639544
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76935067
60Glutamatergic synapse_Homo sapiens_hsa047240.75223188
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72538415
62Ovarian steroidogenesis_Homo sapiens_hsa049130.72487243
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72213705
64Metabolic pathways_Homo sapiens_hsa011000.72018456
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71868477
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70425633
67Nucleotide excision repair_Homo sapiens_hsa034200.68715659
68Chemical carcinogenesis_Homo sapiens_hsa052040.67381706
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.67054848
70beta-Alanine metabolism_Homo sapiens_hsa004100.65473427
71Serotonergic synapse_Homo sapiens_hsa047260.65270518
72Pyrimidine metabolism_Homo sapiens_hsa002400.63861559
73Oocyte meiosis_Homo sapiens_hsa041140.62007180
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61911683
75Fatty acid metabolism_Homo sapiens_hsa012120.61175512
76Dopaminergic synapse_Homo sapiens_hsa047280.60298416
77Retinol metabolism_Homo sapiens_hsa008300.57132541
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.56455503
79Base excision repair_Homo sapiens_hsa034100.54919817
80Pyruvate metabolism_Homo sapiens_hsa006200.53672297
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50865985
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50763780
83Arginine and proline metabolism_Homo sapiens_hsa003300.50407495
84Fat digestion and absorption_Homo sapiens_hsa049750.50181298
85Glycerolipid metabolism_Homo sapiens_hsa005610.47010331
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46820233
87Alzheimers disease_Homo sapiens_hsa050100.46266288
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.45898055
89Lysine degradation_Homo sapiens_hsa003100.45257952
90Hedgehog signaling pathway_Homo sapiens_hsa043400.43839526
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.43302655
92Synaptic vesicle cycle_Homo sapiens_hsa047210.43154554
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42841839
94Renin secretion_Homo sapiens_hsa049240.41127906
95Glutathione metabolism_Homo sapiens_hsa004800.40613121
96Amphetamine addiction_Homo sapiens_hsa050310.39830880
97Long-term depression_Homo sapiens_hsa047300.39204418
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38750879
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38330560
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37767585

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