C3ORF33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1water-soluble vitamin biosynthetic process (GO:0042364)4.38110471
2protein complex biogenesis (GO:0070271)4.05743441
3behavioral response to nicotine (GO:0035095)4.03869794
4fucose catabolic process (GO:0019317)4.00878497
5L-fucose metabolic process (GO:0042354)4.00878497
6L-fucose catabolic process (GO:0042355)4.00878497
7respiratory chain complex IV assembly (GO:0008535)3.99163282
8mitochondrial respiratory chain complex I assembly (GO:0032981)3.93669715
9NADH dehydrogenase complex assembly (GO:0010257)3.93669715
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.93669715
11mitochondrial respiratory chain complex assembly (GO:0033108)3.86760784
12platelet dense granule organization (GO:0060155)3.77955425
13protein-cofactor linkage (GO:0018065)3.71208074
14replication fork processing (GO:0031297)3.59737816
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.55764264
16establishment of protein localization to mitochondrial membrane (GO:0090151)3.53601823
17cytochrome complex assembly (GO:0017004)3.47817684
18ATP synthesis coupled proton transport (GO:0015986)3.47355973
19energy coupled proton transport, down electrochemical gradient (GO:0015985)3.47355973
20DNA deamination (GO:0045006)3.45648522
21peptidyl-histidine modification (GO:0018202)3.37141729
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.36116773
23negative regulation of telomere maintenance (GO:0032205)3.25885889
24piRNA metabolic process (GO:0034587)3.17098882
25epithelial cilium movement (GO:0003351)3.15519069
26cellular ketone body metabolic process (GO:0046950)3.12811148
27mannosylation (GO:0097502)3.10426793
28protein neddylation (GO:0045116)3.06362575
29chaperone-mediated protein transport (GO:0072321)3.03262988
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.02806989
31ketone body metabolic process (GO:1902224)2.94437049
32detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.92875471
33preassembly of GPI anchor in ER membrane (GO:0016254)2.90427060
34DNA double-strand break processing (GO:0000729)2.89550621
35nonmotile primary cilium assembly (GO:0035058)2.88951809
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.87934239
37RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.87934239
38electron transport chain (GO:0022900)2.87331932
39cullin deneddylation (GO:0010388)2.85669914
40respiratory electron transport chain (GO:0022904)2.83437266
41response to pheromone (GO:0019236)2.82480878
42protein localization to cilium (GO:0061512)2.80978430
43axoneme assembly (GO:0035082)2.80807610
44detection of light stimulus involved in sensory perception (GO:0050962)2.80179516
45detection of light stimulus involved in visual perception (GO:0050908)2.80179516
46intracellular protein transmembrane import (GO:0044743)2.79310722
47maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.78488243
48transcription elongation from RNA polymerase III promoter (GO:0006385)2.77187785
49termination of RNA polymerase III transcription (GO:0006386)2.77187785
50protein deneddylation (GO:0000338)2.74593161
51ubiquinone biosynthetic process (GO:0006744)2.73527950
52resolution of meiotic recombination intermediates (GO:0000712)2.72108815
53cilium morphogenesis (GO:0060271)2.71602309
54kynurenine metabolic process (GO:0070189)2.69300748
55anterograde synaptic vesicle transport (GO:0048490)2.69128315
56nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.68702717
57somatic hypermutation of immunoglobulin genes (GO:0016446)2.68477920
58somatic diversification of immune receptors via somatic mutation (GO:0002566)2.68477920
59maturation of 5.8S rRNA (GO:0000460)2.66740253
60pyrimidine nucleobase catabolic process (GO:0006208)2.65864151
61S-adenosylmethionine metabolic process (GO:0046500)2.65835975
62exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.65455958
63ubiquinone metabolic process (GO:0006743)2.64550357
64reciprocal meiotic recombination (GO:0007131)2.64412555
65reciprocal DNA recombination (GO:0035825)2.64412555
66L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.60622072
67indolalkylamine metabolic process (GO:0006586)2.58628903
68recombinational repair (GO:0000725)2.58174772
69proteasome assembly (GO:0043248)2.56739954
70double-strand break repair via homologous recombination (GO:0000724)2.55525242
71protein polyglutamylation (GO:0018095)2.55409236
72regulation of cilium movement (GO:0003352)2.53210779
73intraciliary transport (GO:0042073)2.52901012
74negative regulation of transcription regulatory region DNA binding (GO:2000678)2.51570184
75positive regulation of mitochondrial fission (GO:0090141)2.51435073
76tRNA processing (GO:0008033)2.51405646
77regulation of mitotic spindle checkpoint (GO:1903504)2.50453181
78regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.50453181
79male meiosis I (GO:0007141)2.48064072
80regulation of nuclear cell cycle DNA replication (GO:0033262)2.48001463
81retinal cone cell development (GO:0046549)2.47804831
82protein K11-linked deubiquitination (GO:0035871)2.47344488
83negative regulation of DNA-dependent DNA replication (GO:2000104)2.45930204
84C4-dicarboxylate transport (GO:0015740)2.45640884
85RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.45258619
86regulation of glucokinase activity (GO:0033131)2.44699990
87regulation of hexokinase activity (GO:1903299)2.44699990
88synapsis (GO:0007129)2.44480732
89pseudouridine synthesis (GO:0001522)2.43723338
90regulation of telomere maintenance (GO:0032204)2.43582036
91indole-containing compound catabolic process (GO:0042436)2.40597840
92indolalkylamine catabolic process (GO:0046218)2.40597840
93tryptophan catabolic process (GO:0006569)2.40597840
94hydrogen ion transmembrane transport (GO:1902600)2.39462885
95multicellular organism reproduction (GO:0032504)2.39444352
96meiotic chromosome segregation (GO:0045132)2.39359877
97cilium organization (GO:0044782)2.37771515
98inositol phosphate catabolic process (GO:0071545)2.37378522
99iron-sulfur cluster assembly (GO:0016226)2.36947319
100metallo-sulfur cluster assembly (GO:0031163)2.36947319

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.68893519
2VDR_22108803_ChIP-Seq_LS180_Human3.36811461
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.88050504
4EZH2_22144423_ChIP-Seq_EOC_Human2.83987931
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.82533705
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.77441451
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69858610
8IGF1R_20145208_ChIP-Seq_DFB_Human2.53115936
9GBX2_23144817_ChIP-Seq_PC3_Human2.52272015
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44085865
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.40665791
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.36677755
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.29021588
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28919179
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.28571731
16FUS_26573619_Chip-Seq_HEK293_Human2.24507241
17EWS_26573619_Chip-Seq_HEK293_Human2.21619046
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15796584
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96292386
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96087846
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95599691
22TAF15_26573619_Chip-Seq_HEK293_Human1.95426056
23P300_19829295_ChIP-Seq_ESCs_Human1.93481712
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92640960
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86286114
26ELK1_19687146_ChIP-ChIP_HELA_Human1.84253004
27IRF1_19129219_ChIP-ChIP_H3396_Human1.81836970
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.70443124
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.68923670
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.67109888
31MYC_18940864_ChIP-ChIP_HL60_Human1.66858191
32ER_23166858_ChIP-Seq_MCF-7_Human1.63778632
33VDR_23849224_ChIP-Seq_CD4+_Human1.61656288
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.61295549
35TP53_22573176_ChIP-Seq_HFKS_Human1.60350164
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.57179816
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54354744
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.52876372
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51300017
40BCAT_22108803_ChIP-Seq_LS180_Human1.46097471
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41744556
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40173996
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39832831
44CBP_20019798_ChIP-Seq_JUKART_Human1.39832831
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37396931
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33384870
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.33151949
48NANOG_19829295_ChIP-Seq_ESCs_Human1.30560501
49SOX2_19829295_ChIP-Seq_ESCs_Human1.30560501
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30388410
51GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28570773
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28532282
53AR_25329375_ChIP-Seq_VCAP_Human1.27968121
54FOXP3_21729870_ChIP-Seq_TREG_Human1.27671526
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26988295
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.26773726
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26773726
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.26613449
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.25533819
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.24700152
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24540602
62CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24365400
63SMAD4_21799915_ChIP-Seq_A2780_Human1.23099333
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.22595434
65STAT3_23295773_ChIP-Seq_U87_Human1.22408232
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21338692
67TCF4_22108803_ChIP-Seq_LS180_Human1.19670306
68TCF4_23295773_ChIP-Seq_U87_Human1.17846656
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17433169
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17048374
71RNF2_27304074_Chip-Seq_NSC_Mouse1.17036406
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17030351
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12542018
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.12221142
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11846597
76AR_20517297_ChIP-Seq_VCAP_Human1.10900222
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10665766
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09258056
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08545815
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08001631
81NCOR_22424771_ChIP-Seq_293T_Human1.07921096
82REST_21632747_ChIP-Seq_MESCs_Mouse1.07697947
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06454602
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05705452
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05317072
86AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05254430
87FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04510347
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03961528
89ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03838827
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.03621589
91PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03616548
92TAL1_26923725_Chip-Seq_HPCs_Mouse1.03514837
93* RUNX2_22187159_ChIP-Seq_PCA_Human1.03423665
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.03311937
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03296714
96HTT_18923047_ChIP-ChIP_STHdh_Human1.02574640
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02384041
98* HOXB7_26014856_ChIP-Seq_BT474_Human1.01967552
99CREB1_15753290_ChIP-ChIP_HEK293T_Human1.01041726
100CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00562322

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.08433775
2MP0003195_calcinosis2.99078395
3MP0006292_abnormal_olfactory_placode2.71481902
4MP0003880_abnormal_central_pattern2.56904185
5MP0006072_abnormal_retinal_apoptosis2.51709796
6MP0004147_increased_porphyrin_level2.45004818
7MP0002837_dystrophic_cardiac_calcinosis2.44046009
8MP0002102_abnormal_ear_morphology2.38291410
9MP0005551_abnormal_eye_electrophysiolog2.15799909
10MP0001968_abnormal_touch/_nociception2.10484474
11MP0008058_abnormal_DNA_repair2.04195505
12MP0008875_abnormal_xenobiotic_pharmacok1.94037432
13MP0001529_abnormal_vocalization1.89450251
14MP0000372_irregular_coat_pigmentation1.86459581
15MP0003787_abnormal_imprinting1.86294678
16MP0002938_white_spotting1.85417151
17MP0001986_abnormal_taste_sensitivity1.83651630
18MP0005645_abnormal_hypothalamus_physiol1.81229207
19MP0003136_yellow_coat_color1.81048081
20MP0004142_abnormal_muscle_tone1.80895705
21MP0006276_abnormal_autonomic_nervous1.80476928
22MP0005253_abnormal_eye_physiology1.77522296
23MP0002736_abnormal_nociception_after1.73713269
24MP0005646_abnormal_pituitary_gland1.72047118
25MP0009745_abnormal_behavioral_response1.71555458
26MP0002272_abnormal_nervous_system1.70085784
27MP0004133_heterotaxia1.69127279
28MP0009046_muscle_twitch1.68364586
29MP0002653_abnormal_ependyma_morphology1.67443163
30MP0003718_maternal_effect1.64573786
31MP0004885_abnormal_endolymph1.64161993
32MP0002876_abnormal_thyroid_physiology1.59019715
33MP0008872_abnormal_physiological_respon1.58640273
34MP0008995_early_reproductive_senescence1.56301295
35MP0004043_abnormal_pH_regulation1.51917298
36MP0000631_abnormal_neuroendocrine_gland1.50818783
37MP0001984_abnormal_olfaction1.49360213
38MP0003011_delayed_dark_adaptation1.41892534
39MP0001486_abnormal_startle_reflex1.37842469
40MP0002638_abnormal_pupillary_reflex1.36911249
41MP0004742_abnormal_vestibular_system1.36434491
42MP0003122_maternal_imprinting1.33619459
43MP0000569_abnormal_digit_pigmentation1.33224191
44MP0003121_genomic_imprinting1.30051110
45MP0003646_muscle_fatigue1.29683155
46MP0001485_abnormal_pinna_reflex1.29231449
47MP0002557_abnormal_social/conspecific_i1.28757566
48MP0005084_abnormal_gallbladder_morpholo1.24613628
49MP0002735_abnormal_chemical_nociception1.21625984
50MP0005389_reproductive_system_phenotype1.18183009
51MP0008789_abnormal_olfactory_epithelium1.17011320
52MP0001501_abnormal_sleep_pattern1.16445642
53MP0002572_abnormal_emotion/affect_behav1.16205622
54MP0002160_abnormal_reproductive_system1.16157056
55MP0000427_abnormal_hair_cycle1.16151258
56MP0010386_abnormal_urinary_bladder1.12998880
57MP0003786_premature_aging1.12276515
58MP0004145_abnormal_muscle_electrophysio1.11368824
59MP0002163_abnormal_gland_morphology1.11210137
60MP0002067_abnormal_sensory_capabilities1.10664164
61MP0002064_seizures1.09538739
62MP0003186_abnormal_redox_activity1.08569089
63MP0005379_endocrine/exocrine_gland_phen1.08282802
64MP0002234_abnormal_pharynx_morphology1.08160929
65MP0003890_abnormal_embryonic-extraembry1.07821893
66MP0002928_abnormal_bile_duct1.07784364
67MP0001905_abnormal_dopamine_level1.07390882
68MP0001293_anophthalmia1.06390486
69MP0008775_abnormal_heart_ventricle1.04600577
70MP0001919_abnormal_reproductive_system1.04321486
71MP0006036_abnormal_mitochondrial_physio1.02503192
72MP0005195_abnormal_posterior_eye1.02100165
73MP0005423_abnormal_somatic_nervous1.00571138
74MP0001970_abnormal_pain_threshold1.00514207
75MP0005386_behavior/neurological_phenoty0.99784886
76MP0004924_abnormal_behavior0.99784886
77MP0002733_abnormal_thermal_nociception0.99591191
78MP0005075_abnormal_melanosome_morpholog0.99388149
79MP0002210_abnormal_sex_determination0.98583358
80MP0002751_abnormal_autonomic_nervous0.94581987
81MP0005332_abnormal_amino_acid0.94522830
82MP0006035_abnormal_mitochondrial_morpho0.93902970
83MP0002095_abnormal_skin_pigmentation0.93526059
84MP0005410_abnormal_fertilization0.90768696
85MP0001929_abnormal_gametogenesis0.89862825
86MP0003635_abnormal_synaptic_transmissio0.89257439
87MP0002752_abnormal_somatic_nervous0.88071261
88MP0002734_abnormal_mechanical_nocicepti0.87536009
89MP0003698_abnormal_male_reproductive0.86832129
90MP0000653_abnormal_sex_gland0.86126129
91MP0000778_abnormal_nervous_system0.85212811
92MP0002184_abnormal_innervation0.85000862
93MP0004215_abnormal_myocardial_fiber0.82658022
94MP0001764_abnormal_homeostasis0.81752241
95MP0005391_vision/eye_phenotype0.81306012
96MP0003806_abnormal_nucleotide_metabolis0.80672703
97MP0005085_abnormal_gallbladder_physiolo0.80544957
98MP0002063_abnormal_learning/memory/cond0.80393830
99MP0003252_abnormal_bile_duct0.77767756
100MP0002229_neurodegeneration0.76981377

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.90927318
2Pancreatic fibrosis (HP:0100732)3.84890664
3Molar tooth sign on MRI (HP:0002419)3.76274661
4Abnormality of midbrain morphology (HP:0002418)3.76274661
5True hermaphroditism (HP:0010459)3.64653145
6Acute necrotizing encephalopathy (HP:0006965)3.61840134
7Nephronophthisis (HP:0000090)3.27733355
8Abnormal mitochondria in muscle tissue (HP:0008316)3.19432907
9Progressive macrocephaly (HP:0004481)3.16831855
10Mitochondrial inheritance (HP:0001427)3.16535044
11Congenital stationary night blindness (HP:0007642)3.14044675
12Acute encephalopathy (HP:0006846)3.13878485
13Abnormality of the renal cortex (HP:0011035)3.12921665
14Increased CSF lactate (HP:0002490)3.06886914
15Medial flaring of the eyebrow (HP:0010747)3.06218364
16Renal cortical cysts (HP:0000803)2.95713348
17Type II lissencephaly (HP:0007260)2.93802974
18Abnormality of the renal medulla (HP:0100957)2.83934604
19Lipid accumulation in hepatocytes (HP:0006561)2.71644319
20Hepatic necrosis (HP:0002605)2.65880180
21Methylmalonic acidemia (HP:0002912)2.65370271
22Hepatocellular necrosis (HP:0001404)2.64323465
23Abnormality of alanine metabolism (HP:0010916)2.62190173
24Hyperalaninemia (HP:0003348)2.62190173
25Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.62190173
26Increased hepatocellular lipid droplets (HP:0006565)2.61944429
27Gait imbalance (HP:0002141)2.58008286
283-Methylglutaconic aciduria (HP:0003535)2.57857871
29Congenital primary aphakia (HP:0007707)2.46179939
30Methylmalonic aciduria (HP:0012120)2.41369731
31Hypothermia (HP:0002045)2.40683550
32Bile duct proliferation (HP:0001408)2.40606249
33Abnormal biliary tract physiology (HP:0012439)2.40606249
34Chronic hepatic failure (HP:0100626)2.40378155
35Pendular nystagmus (HP:0012043)2.31271938
36Cystic liver disease (HP:0006706)2.30831540
37Abnormal rod and cone electroretinograms (HP:0008323)2.30017572
38Abolished electroretinogram (ERG) (HP:0000550)2.26169828
39Colon cancer (HP:0003003)2.26142818
40Optic disc pallor (HP:0000543)2.24663715
41Sclerocornea (HP:0000647)2.22200039
42Aplasia/Hypoplasia of the tongue (HP:0010295)2.21289827
43Cerebral edema (HP:0002181)2.20748259
44Increased serum lactate (HP:0002151)2.19383930
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.19295782
46Nephrogenic diabetes insipidus (HP:0009806)2.18641666
47Inability to walk (HP:0002540)2.15259979
48Tubular atrophy (HP:0000092)2.14613814
49Abnormality of the labia minora (HP:0012880)2.12185785
50Genital tract atresia (HP:0001827)2.06073056
51Hyperventilation (HP:0002883)2.06009873
52Attenuation of retinal blood vessels (HP:0007843)2.05622427
53Anencephaly (HP:0002323)2.05383123
54Large for gestational age (HP:0001520)2.05267206
55Abnormal drinking behavior (HP:0030082)2.03842914
56Polydipsia (HP:0001959)2.03842914
57Hyperglycinemia (HP:0002154)2.03141776
58Meckel diverticulum (HP:0002245)2.01824397
59Abnormality of the ileum (HP:0001549)2.01774674
60Lactic acidosis (HP:0003128)2.01740092
61Renal Fanconi syndrome (HP:0001994)1.98963088
62Male pseudohermaphroditism (HP:0000037)1.97041197
63Vaginal atresia (HP:0000148)1.96734860
64Congenital hepatic fibrosis (HP:0002612)1.96672423
65Optic nerve hypoplasia (HP:0000609)1.96145131
66Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95821059
67Lissencephaly (HP:0001339)1.95156900
68Aplasia/Hypoplasia of the tibia (HP:0005772)1.94199569
69Intestinal atresia (HP:0011100)1.93988527
70Febrile seizures (HP:0002373)1.93708283
71Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90507511
72Decreased central vision (HP:0007663)1.83565032
73Postaxial foot polydactyly (HP:0001830)1.81904342
74Aplasia/Hypoplasia of the fovea (HP:0008060)1.80174025
75Hypoplasia of the fovea (HP:0007750)1.80174025
76Lethargy (HP:0001254)1.78997913
77Abnormal number of erythroid precursors (HP:0012131)1.77376811
78Short tibia (HP:0005736)1.77077961
79Abnormality of urine glucose concentration (HP:0011016)1.76295109
80Glycosuria (HP:0003076)1.76295109
81Postaxial hand polydactyly (HP:0001162)1.75866163
82Decreased activity of mitochondrial respiratory chain (HP:0008972)1.75752318
83Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.75752318
84Pachygyria (HP:0001302)1.75548301
85Progressive inability to walk (HP:0002505)1.74986645
86Congenital, generalized hypertrichosis (HP:0004540)1.74519473
87Supernumerary spleens (HP:0009799)1.74492742
88Concave nail (HP:0001598)1.74306971
89Cerebellar dysplasia (HP:0007033)1.72510028
90Severe muscular hypotonia (HP:0006829)1.72438910
91Retinal dysplasia (HP:0007973)1.71621950
92Respiratory failure (HP:0002878)1.71601133
93Abnormality of DNA repair (HP:0003254)1.71351718
94Absent thumb (HP:0009777)1.71274388
95Polyuria (HP:0000103)1.71085985
96Aplasia/hypoplasia of the uterus (HP:0008684)1.70781360
97Furrowed tongue (HP:0000221)1.70759786
98Increased intramyocellular lipid droplets (HP:0012240)1.70073937
99Chromsome breakage (HP:0040012)1.68926786
100Hypomagnesemia (HP:0002917)1.68205209

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.66035021
2ADRBK22.95239420
3MAP4K22.86073786
4PINK12.72009529
5WNK32.70251534
6NUAK12.57978578
7BMPR1B2.56450670
8ZAK2.48645446
9TAOK32.44658518
10CASK2.39652411
11MAP3K42.24755710
12GRK12.13376657
13STK162.09199957
14WNK42.05914011
15MAPK131.77875283
16TXK1.68506284
17DYRK21.65755657
18MAP2K71.61560034
19VRK21.49958982
20MKNK21.48840493
21BCKDK1.47677967
22TLK11.43866163
23CSNK1G11.42156297
24TRIM281.39282494
25INSRR1.30998335
26VRK11.29072997
27STK391.28676681
28PAK31.26122963
29OXSR11.23357819
30CSNK1G31.22587372
31ERBB31.20697539
32EIF2AK31.18217794
33EPHA41.16807945
34PHKG21.16302510
35PHKG11.16302510
36CSNK1G21.13411955
37TNIK1.10866755
38MST41.10258545
39ACVR1B1.07552871
40WEE11.06215598
41PLK31.06058308
42PRKCE0.99625600
43CSNK1A1L0.97622569
44NME10.97359165
45BCR0.95910620
46CCNB10.95176720
47PRKCG0.91618315
48MARK10.88771168
49PLK40.88656880
50MKNK10.88431414
51NEK10.87278854
52BRSK20.85002146
53PLK20.84522698
54TSSK60.82610440
55TIE10.81198315
56ADRBK10.80375120
57SRPK10.75780149
58STK38L0.75183581
59MAP3K120.74341727
60DAPK20.73362932
61CAMKK20.72936988
62PLK10.72046422
63DYRK30.70265150
64NEK20.68632396
65BUB10.68258439
66PRKCI0.68207659
67EIF2AK10.64492909
68TGFBR10.64397428
69NTRK30.62868521
70PKN10.59193965
71MUSK0.58982470
72CSNK1A10.57154027
73ATR0.56974754
74NTRK20.53803061
75CAMK2A0.52687274
76STK30.51946068
77OBSCN0.51174245
78MINK10.50738813
79PRKACA0.49091403
80NLK0.48414068
81PIK3CA0.48336636
82DYRK1A0.44798635
83RPS6KA50.44112729
84TAF10.43906266
85MAP3K90.43518510
86ATM0.39980456
87CDC70.39959079
88MAP2K40.39110164
89PRKG10.38798028
90PRKCQ0.38189030
91EIF2AK20.38091376
92IKBKB0.36575547
93PASK0.36575111
94PNCK0.36127126
95LIMK10.35283826
96MAPKAPK50.34327111
97CSNK2A10.33550698
98PRKCA0.32421638
99CSNK1D0.30068763
100IRAK10.28949910

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.20711331
2Protein export_Homo sapiens_hsa030603.07048863
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.73780771
4Parkinsons disease_Homo sapiens_hsa050122.57558216
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.30299429
6RNA polymerase_Homo sapiens_hsa030202.24896583
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.20348544
8Phototransduction_Homo sapiens_hsa047442.18050544
9Butanoate metabolism_Homo sapiens_hsa006502.11865613
10Proteasome_Homo sapiens_hsa030502.09177311
11Basal transcription factors_Homo sapiens_hsa030222.05935536
12Propanoate metabolism_Homo sapiens_hsa006402.00688831
13Homologous recombination_Homo sapiens_hsa034401.99948757
14Nitrogen metabolism_Homo sapiens_hsa009101.97233299
15Fanconi anemia pathway_Homo sapiens_hsa034601.84013911
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.77987327
17Huntingtons disease_Homo sapiens_hsa050161.71250908
18Linoleic acid metabolism_Homo sapiens_hsa005911.61332054
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.59848387
20Alzheimers disease_Homo sapiens_hsa050101.57380824
21Nicotine addiction_Homo sapiens_hsa050331.55486855
22One carbon pool by folate_Homo sapiens_hsa006701.54814174
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53731350
24Selenocompound metabolism_Homo sapiens_hsa004501.53542060
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.53413667
26RNA degradation_Homo sapiens_hsa030181.50838201
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48780333
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.45886107
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44214661
30Cardiac muscle contraction_Homo sapiens_hsa042601.40403621
31Non-homologous end-joining_Homo sapiens_hsa034501.38567305
32Steroid biosynthesis_Homo sapiens_hsa001001.37211125
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.34381816
34Peroxisome_Homo sapiens_hsa041461.33012055
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32577116
36Ribosome_Homo sapiens_hsa030101.32290096
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27961146
38Caffeine metabolism_Homo sapiens_hsa002321.27565289
39Tryptophan metabolism_Homo sapiens_hsa003801.23316490
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23060768
41Sulfur metabolism_Homo sapiens_hsa009201.08605914
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07394000
43Ether lipid metabolism_Homo sapiens_hsa005651.06809071
44Mismatch repair_Homo sapiens_hsa034301.06689546
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.04720432
46Collecting duct acid secretion_Homo sapiens_hsa049661.00858563
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98120653
48Purine metabolism_Homo sapiens_hsa002300.98053538
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96785788
50Regulation of autophagy_Homo sapiens_hsa041400.93094627
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92551535
52Nucleotide excision repair_Homo sapiens_hsa034200.91042400
53Pyrimidine metabolism_Homo sapiens_hsa002400.88827348
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.85902065
55Folate biosynthesis_Homo sapiens_hsa007900.83939107
56Olfactory transduction_Homo sapiens_hsa047400.83749417
57Fatty acid elongation_Homo sapiens_hsa000620.82973276
58RNA transport_Homo sapiens_hsa030130.82819348
59Metabolic pathways_Homo sapiens_hsa011000.81373411
60Morphine addiction_Homo sapiens_hsa050320.80831439
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79420594
62GABAergic synapse_Homo sapiens_hsa047270.77225517
63Taste transduction_Homo sapiens_hsa047420.77016911
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76427996
65Chemical carcinogenesis_Homo sapiens_hsa052040.75223535
66Insulin secretion_Homo sapiens_hsa049110.74925077
67Pyruvate metabolism_Homo sapiens_hsa006200.72890384
68beta-Alanine metabolism_Homo sapiens_hsa004100.71639464
69Retinol metabolism_Homo sapiens_hsa008300.70592288
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70275087
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.69531986
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68627872
73Vitamin B6 metabolism_Homo sapiens_hsa007500.68092292
74Base excision repair_Homo sapiens_hsa034100.65603005
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64058319
76Fat digestion and absorption_Homo sapiens_hsa049750.59925657
77Sulfur relay system_Homo sapiens_hsa041220.58931161
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58409191
79Serotonergic synapse_Homo sapiens_hsa047260.58334743
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54008464
81Glutamatergic synapse_Homo sapiens_hsa047240.53776083
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53244721
83Fatty acid metabolism_Homo sapiens_hsa012120.52057013
84Arachidonic acid metabolism_Homo sapiens_hsa005900.51648436
85Circadian rhythm_Homo sapiens_hsa047100.51466219
86ABC transporters_Homo sapiens_hsa020100.51429079
87Fatty acid degradation_Homo sapiens_hsa000710.51273501
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.48959776
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48883784
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48701019
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46565098
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45311813
93Mineral absorption_Homo sapiens_hsa049780.45310297
94Circadian entrainment_Homo sapiens_hsa047130.44981724
95Spliceosome_Homo sapiens_hsa030400.44885108
96Vitamin digestion and absorption_Homo sapiens_hsa049770.43910522
97Asthma_Homo sapiens_hsa053100.41406562
98Dopaminergic synapse_Homo sapiens_hsa047280.38543129
99Type I diabetes mellitus_Homo sapiens_hsa049400.38200116
100Ovarian steroidogenesis_Homo sapiens_hsa049130.35626117

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