C3ORF30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1microtubule depolymerization (GO:0007019)9.10248464
2sperm capacitation (GO:0048240)8.47617978
3chromosome condensation (GO:0030261)8.35011860
4protein targeting to Golgi (GO:0000042)8.17970592
5DNA packaging (GO:0006323)8.13043934
6spermatid development (GO:0007286)8.12570122
7plasma membrane fusion (GO:0045026)8.09794971
8establishment of protein localization to Golgi (GO:0072600)7.91641003
9protein polyglutamylation (GO:0018095)7.77710432
10microtubule polymerization or depolymerization (GO:0031109)7.67233507
11retrograde transport, vesicle recycling within Golgi (GO:0000301)7.63539306
12rRNA methylation (GO:0031167)7.49625792
13sperm-egg recognition (GO:0035036)7.24873535
14multicellular organism reproduction (GO:0032504)7.23308362
15single strand break repair (GO:0000012)7.16304937
16spermatid nucleus differentiation (GO:0007289)6.61193422
17binding of sperm to zona pellucida (GO:0007339)6.55392885
18reproduction (GO:0000003)6.50390358
19phosphatidylethanolamine biosynthetic process (GO:0006646)6.50375304
20calcium ion-dependent exocytosis (GO:0017156)6.41679203
21rRNA modification (GO:0000154)6.33941812
22axonemal dynein complex assembly (GO:0070286)6.33591483
23spermatogenesis (GO:0007283)6.33396326
24male gamete generation (GO:0048232)6.31119760
25microtubule severing (GO:0051013)6.28795152
26centriole replication (GO:0007099)6.12276718
27response to pheromone (GO:0019236)6.10780689
28negative regulation of inclusion body assembly (GO:0090084)6.04923608
29phosphatidylethanolamine metabolic process (GO:0046337)6.00384462
30cell-cell recognition (GO:0009988)5.99299629
31protein localization to Golgi apparatus (GO:0034067)5.94772574
32gamete generation (GO:0007276)5.79959684
33regulation of cilium movement (GO:0003352)5.62973494
34centriole assembly (GO:0098534)5.50355562
35sexual reproduction (GO:0019953)5.44734033
36single fertilization (GO:0007338)5.38328229
37cilium or flagellum-dependent cell motility (GO:0001539)5.30380116
38seminiferous tubule development (GO:0072520)5.21138180
39motile cilium assembly (GO:0044458)5.17176768
40regulation of centriole replication (GO:0046599)5.06277851
41RNA destabilization (GO:0050779)5.06126162
42epithelial cilium movement (GO:0003351)4.79038370
43regulation of Rab GTPase activity (GO:0032313)4.74688718
44positive regulation of Rab GTPase activity (GO:0032851)4.74688718
45cellular ketone body metabolic process (GO:0046950)4.73478559
46multicellular organismal reproductive process (GO:0048609)4.61773770
47germ cell development (GO:0007281)4.59491330
48fertilization (GO:0009566)4.52939565
49glomerular visceral epithelial cell development (GO:0072015)4.39205308
50cellular process involved in reproduction in multicellular organism (GO:0022412)4.37367917
51cell wall macromolecule catabolic process (GO:0016998)4.22305998
52regulation of inclusion body assembly (GO:0090083)4.20818802
53glomerular epithelial cell development (GO:0072310)4.20297959
54cilium movement (GO:0003341)4.20173198
55ketone body metabolic process (GO:1902224)4.16512575
56regulation of transcription involved in cell fate commitment (GO:0060850)4.06984273
57nucleus organization (GO:0006997)4.06243180
58microtubule nucleation (GO:0007020)3.97843387
59cell wall macromolecule metabolic process (GO:0044036)3.97291697
60organic cation transport (GO:0015695)3.91451918
61multicellular organismal movement (GO:0050879)3.84865904
62musculoskeletal movement (GO:0050881)3.84865904
63glycerol ether metabolic process (GO:0006662)3.83751256
64nuclear pore complex assembly (GO:0051292)3.78706520
65membrane protein intracellular domain proteolysis (GO:0031293)3.72999122
66chromatin silencing (GO:0006342)3.54048121
67regulation of microtubule-based movement (GO:0060632)3.54013909
68ether metabolic process (GO:0018904)3.53512436
69negative regulation of Rho protein signal transduction (GO:0035024)3.51446535
70protein depolymerization (GO:0051261)3.33213417
71regulation of ARF GTPase activity (GO:0032312)3.29937549
72polyamine biosynthetic process (GO:0006596)3.23792052
73regulation of phosphoprotein phosphatase activity (GO:0043666)3.20868171
74intra-Golgi vesicle-mediated transport (GO:0006891)3.16873976
75coenzyme catabolic process (GO:0009109)3.13702764
76cellular response to pH (GO:0071467)3.08175067
77cerebral cortex neuron differentiation (GO:0021895)3.04699250
78receptor recycling (GO:0001881)3.03015479
79multicellular organismal development (GO:0007275)3.02706243
80epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.01152144
81response to acidic pH (GO:0010447)3.00867637
82axoneme assembly (GO:0035082)3.00675777
83ventricular system development (GO:0021591)3.00053959
84protein-DNA complex disassembly (GO:0032986)2.95674147
85nucleosome disassembly (GO:0006337)2.95674147
86peptidyl-threonine dephosphorylation (GO:0035970)2.95589200
87cell recognition (GO:0008037)2.95106149
88Golgi to endosome transport (GO:0006895)2.90836906
89pore complex assembly (GO:0046931)2.87117536
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.86007029
91male meiosis (GO:0007140)2.84304967
92cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.82965880
93regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.82486632
94regulation of interleukin-13 production (GO:0032656)2.82374757
95nuclear pore organization (GO:0006999)2.76404932
96positive regulation of guanylate cyclase activity (GO:0031284)2.72984255
97mitochondrial fission (GO:0000266)2.70544865
98sperm motility (GO:0030317)12.1178170
99acrosome reaction (GO:0007340)11.1563497
100fusion of sperm to egg plasma membrane (GO:0007342)10.7303908

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.20500252
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.51435562
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.23646658
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.14783738
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.72485997
6EZH2_22144423_ChIP-Seq_EOC_Human2.68176248
7POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.42703324
8TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.42703324
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.39843091
10CBP_20019798_ChIP-Seq_JUKART_Human2.38736386
11IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.38736386
12FUS_26573619_Chip-Seq_HEK293_Human2.29125395
13* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.24180782
14VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.11910746
15WDR5_24793694_ChIP-Seq_LNCAP_Human1.79761086
16DROSHA_22980978_ChIP-Seq_HELA_Human1.78980598
17ER_23166858_ChIP-Seq_MCF-7_Human1.76046320
18UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.73578931
19GBX2_23144817_ChIP-Seq_PC3_Human1.70443895
20SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.69977431
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68210194
22SMAD4_21741376_ChIP-Seq_EPCs_Human1.65228785
23ARNT_22903824_ChIP-Seq_MCF-7_Human1.62215494
24ERA_21632823_ChIP-Seq_H3396_Human1.58348241
25MYC_19829295_ChIP-Seq_ESCs_Human1.57923583
26RAC3_21632823_ChIP-Seq_H3396_Human1.57817359
27SMAD3_21741376_ChIP-Seq_EPCs_Human1.55238490
28TP53_18474530_ChIP-ChIP_U2OS_Human1.54926665
29P300_19829295_ChIP-Seq_ESCs_Human1.54123378
30NANOG_20526341_ChIP-Seq_ESCs_Human1.53307047
31CBX2_22325352_ChIP-Seq_293T-Rex_Human1.52701207
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49357740
33AR_25329375_ChIP-Seq_VCAP_Human1.48813918
34AUTS2_25519132_ChIP-Seq_293T-REX_Human1.48640296
35ETV1_20927104_ChIP-Seq_GIST48_Human1.48345253
36EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.46817433
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.45054799
38TDRD3_21172665_ChIP-Seq_MCF-7_Human1.44540197
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44271932
40TAF15_26573619_Chip-Seq_HEK293_Human1.43918634
41ERG_20517297_ChIP-Seq_VCAP_Human1.42876423
42ELF1_20517297_ChIP-Seq_JURKAT_Human1.41827389
43RBPJ_21746931_ChIP-Seq_IB4_Human1.41754726
44HNFA_21074721_ChIP-Seq_CACO-2_Human1.40725981
45RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.37236303
46EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.37230086
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37039402
48CTCF_27219007_Chip-Seq_Bcells_Human1.36630972
49CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.35395470
50OCT4_20526341_ChIP-Seq_ESCs_Human1.34807082
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34718159
52TBL1_22424771_ChIP-Seq_293T_Human1.34203850
53SMAD4_21799915_ChIP-Seq_A2780_Human1.31629557
54TAF2_19829295_ChIP-Seq_ESCs_Human1.30659871
55NFYB_21822215_ChIP-Seq_K562_Human1.30155964
56STAT3_23295773_ChIP-Seq_U87_Human1.29741902
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28240134
58ETV2_25802403_ChIP-Seq_MESCs_Mouse1.27478214
59ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26342342
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.24622884
61PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.22703999
62SMAD3_21741376_ChIP-Seq_ESCs_Human1.22546153
63NANOG_19829295_ChIP-Seq_ESCs_Human1.21859346
64SOX2_19829295_ChIP-Seq_ESCs_Human1.21859346
65PHF8_20622853_ChIP-Seq_HELA_Human1.21405398
66SMAD4_21741376_ChIP-Seq_HESCs_Human1.21159899
67SMC4_20622854_ChIP-Seq_HELA_Human1.20399110
68PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.20084767
69YY1_22570637_ChIP-Seq_MALME-3M_Human1.17150295
70SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16514039
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15473795
72VDR_22108803_ChIP-Seq_LS180_Human1.15211519
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14640818
74SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14088738
75GATA6_21074721_ChIP-Seq_CACO-2_Human1.12807338
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12695736
77RUNX2_22187159_ChIP-Seq_PCA_Human1.12416207
78NFYA_21822215_ChIP-Seq_K562_Human1.11515480
79BCL6_27268052_Chip-Seq_Bcells_Human1.11326058
80ZNF274_21170338_ChIP-Seq_K562_Hela1.10624711
81KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.10273881
82TP63_22573176_ChIP-Seq_HFKS_Human1.09885940
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09525443
84PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09492426
85GATA3_21878914_ChIP-Seq_MCF-7_Human1.08975173
86CEBPB_22108803_ChIP-Seq_LS180_Human1.08145880
87PRDM14_20953172_ChIP-Seq_ESCs_Human1.07804650
88PHF8_20622854_ChIP-Seq_HELA_Human1.04267796
89GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03718877
90E2F1_20622854_ChIP-Seq_HELA_Human1.03677892
91RUNX1_26923725_Chip-Seq_HPCs_Mouse1.03450396
92OCT1_27270436_Chip-Seq_PROSTATE_Human1.03118234
93BCOR_27268052_Chip-Seq_Bcells_Human1.02816036
94CTCF_20526341_ChIP-Seq_ESCs_Human1.00674255
95SOX2_22085726_ChIP-Seq_NPCs_Mouse1.00215609
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00079502
97KDM2B_26808549_Chip-Seq_REH_Human0.99795409
98TCF4_18268006_ChIP-ChIP_LS174T_Human0.99639286
99TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.97468011
100P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.97204934

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.40345267
2MP0003878_abnormal_ear_physiology5.40345267
3MP0005670_abnormal_white_adipose4.49489580
4MP0003698_abnormal_male_reproductive4.39012852
5MP0001929_abnormal_gametogenesis3.87621112
6MP0001348_abnormal_lacrimal_gland2.76582986
7MP0002161_abnormal_fertility/fecundity2.40642526
8MP0003646_muscle_fatigue2.33345253
9MP0001485_abnormal_pinna_reflex2.06996759
10MP0003718_maternal_effect2.02550351
11MP0005410_abnormal_fertilization11.9081340
12MP0002210_abnormal_sex_determination1.82665272
13MP0002249_abnormal_larynx_morphology1.79550481
14MP0002234_abnormal_pharynx_morphology1.78610022
15MP0000678_abnormal_parathyroid_gland1.74491843
16MP0001486_abnormal_startle_reflex1.74005214
17MP0002132_abnormal_respiratory_system1.73531542
18MP0005451_abnormal_body_composition1.69492979
19MP0005310_abnormal_salivary_gland1.57860130
20MP0003879_abnormal_hair_cell1.55497670
21MP0004859_abnormal_synaptic_plasticity1.54278369
22MP0003011_delayed_dark_adaptation1.51094425
23MP0001145_abnormal_male_reproductive1.50250251
24MP0005423_abnormal_somatic_nervous1.42091813
25MP0000653_abnormal_sex_gland1.41416345
26MP0004742_abnormal_vestibular_system1.36220115
27MP0005379_endocrine/exocrine_gland_phen1.29031858
28MP0001765_abnormal_ion_homeostasis1.25746526
29MP0001968_abnormal_touch/_nociception1.19233766
30MP0001984_abnormal_olfaction1.18528108
31MP0001963_abnormal_hearing_physiology1.18091352
32MP0002282_abnormal_trachea_morphology1.17938148
33MP0002735_abnormal_chemical_nociception1.10447145
34MP0002138_abnormal_hepatobiliary_system1.07088115
35MP0000534_abnormal_ureter_morphology1.06331864
36MP0005395_other_phenotype1.06057368
37MP0002127_abnormal_cardiovascular_syste1.01315754
38MP0000049_abnormal_middle_ear1.01124767
39MP0004510_myositis0.99343521
40MP0005551_abnormal_eye_electrophysiolog0.98476343
41MP0004484_altered_response_of0.95873230
42MP0005083_abnormal_biliary_tract0.94226550
43MP0000026_abnormal_inner_ear0.94146222
44MP0005253_abnormal_eye_physiology0.91270549
45MP0009053_abnormal_anal_canal0.90496953
46MP0009115_abnormal_fat_cell0.87635854
47MP0008569_lethality_at_weaning0.83441550
48MP0008995_early_reproductive_senescence0.81084337
49MP0000955_abnormal_spinal_cord0.79254631
50MP0002229_neurodegeneration0.79045151
51MP0005248_abnormal_Harderian_gland0.78094892
52MP0002067_abnormal_sensory_capabilities0.77940271
53MP0004085_abnormal_heartbeat0.77875584
54MP0005636_abnormal_mineral_homeostasis0.75904500
55MP0002557_abnormal_social/conspecific_i0.72948427
56MP0002733_abnormal_thermal_nociception0.72878313
57MP0002572_abnormal_emotion/affect_behav0.70573873
58MP0002734_abnormal_mechanical_nocicepti0.70463547
59MP0003137_abnormal_impulse_conducting0.69570009
60MP0002272_abnormal_nervous_system0.69436899
61MP0003119_abnormal_digestive_system0.69332220
62MP0000613_abnormal_salivary_gland0.65810299
63MP0008877_abnormal_DNA_methylation0.64770372
64MP0005666_abnormal_adipose_tissue0.64720445
65MP0002653_abnormal_ependyma_morphology0.63034099
66MP0002822_catalepsy0.59999676
67MP0009745_abnormal_behavioral_response0.59757373
68MP0004782_abnormal_surfactant_physiolog0.57296206
69MP0005408_hypopigmentation0.56966461
70MP0001270_distended_abdomen0.55291693
71MP0001905_abnormal_dopamine_level0.55008875
72MP0000230_abnormal_systemic_arterial0.54568114
73MP0001970_abnormal_pain_threshold0.53043022
74MP0009697_abnormal_copulation0.50507152
75MP0000681_abnormal_thyroid_gland0.49009956
76MP0004036_abnormal_muscle_relaxation0.48546309
77MP0005167_abnormal_blood-brain_barrier0.48477447
78MP0002168_other_aberrant_phenotype0.48018065
79MP0002736_abnormal_nociception_after0.47802430
80MP0002184_abnormal_innervation0.46100161
81MP0003635_abnormal_synaptic_transmissio0.45552816
82MP0010329_abnormal_lipoprotein_level0.44814949
83MP0001666_abnormal_nutrient_absorption0.44069772
84MP0005391_vision/eye_phenotype0.44054228
85MP0004084_abnormal_cardiac_muscle0.43964336
86MP0002109_abnormal_limb_morphology0.43926192
87MP0004233_abnormal_muscle_weight0.43426005
88MP0005367_renal/urinary_system_phenotyp0.43187997
89MP0000516_abnormal_urinary_system0.43187997
90MP0000470_abnormal_stomach_morphology0.42833373
91MP0003632_abnormal_nervous_system0.42552372
92MP0001501_abnormal_sleep_pattern0.41468097
93MP0002882_abnormal_neuron_morphology0.40787944
94MP0001440_abnormal_grooming_behavior0.40604025
95MP0003631_nervous_system_phenotype0.39378085
96MP0005084_abnormal_gallbladder_morpholo0.39267567
97MP0003699_abnormal_female_reproductive0.38276141
98MP0003935_abnormal_craniofacial_develop0.37233882
99MP0005375_adipose_tissue_phenotype0.36053851
100MP0003077_abnormal_cell_cycle0.35843079

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.19332673
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.50392451
3Absent/shortened dynein arms (HP:0200106)6.50392451
4Tubulointerstitial nephritis (HP:0001970)6.18585064
5Chronic hepatic failure (HP:0100626)5.86765852
6Asymmetric septal hypertrophy (HP:0001670)4.97245517
7Abnormal respiratory motile cilium physiology (HP:0012261)4.84461307
8Abnormal ciliary motility (HP:0012262)4.83541078
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.82781524
10Attenuation of retinal blood vessels (HP:0007843)4.81126846
11Abnormality of macular pigmentation (HP:0008002)4.58238070
12Abnormal respiratory epithelium morphology (HP:0012253)4.48599480
13Abnormal respiratory motile cilium morphology (HP:0005938)4.48599480
14Bony spicule pigmentary retinopathy (HP:0007737)4.45278438
15Cone-rod dystrophy (HP:0000548)4.39192896
16Resting tremor (HP:0002322)4.21107282
17Hyperkalemia (HP:0002153)4.15185612
18Nasal polyposis (HP:0100582)4.12645319
19Male infertility (HP:0003251)4.12425162
20Infertility (HP:0000789)3.96062575
21Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.80492161
22Hypoalphalipoproteinemia (HP:0003233)3.72965940
23Progressive sensorineural hearing impairment (HP:0000408)3.60058246
24Bell-shaped thorax (HP:0001591)3.59510478
25Hypoplasia of the thymus (HP:0000778)3.58146551
26Hypoplastic ischia (HP:0003175)3.42275057
27Abnormality of the nasal mucosa (HP:0000433)3.37088069
28Menstrual irregularities (HP:0000858)3.35445496
29Aplasia/Hypoplasia of the earlobes (HP:0009906)3.29394252
30Abnormality of dental color (HP:0011073)3.28404656
31Abnormal rod and cone electroretinograms (HP:0008323)3.26161957
32Amelogenesis imperfecta (HP:0000705)3.21089545
33Renovascular hypertension (HP:0100817)3.16544844
34Potter facies (HP:0002009)3.13868253
35Facial shape deformation (HP:0011334)3.13868253
36Abnormality of the ischium (HP:0003174)3.09155732
37Rhinitis (HP:0012384)3.06611838
38Impulsivity (HP:0100710)2.97493763
39Postural instability (HP:0002172)2.94067083
40Insulin-resistant diabetes mellitus (HP:0000831)2.90796120
41Portal hypertension (HP:0001409)2.90533718
42Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.88912612
43Progressive cerebellar ataxia (HP:0002073)2.81562591
44Enlarged epiphyses (HP:0010580)2.81269984
45Truncal obesity (HP:0001956)2.79529188
46Nephronophthisis (HP:0000090)2.76977921
47Stage 5 chronic kidney disease (HP:0003774)2.72473119
48Tubulointerstitial abnormality (HP:0001969)2.72291264
49Abnormal spermatogenesis (HP:0008669)2.67482577
50Abnormality of the hepatic vasculature (HP:0006707)2.67212615
51Generalized aminoaciduria (HP:0002909)2.60790233
52Abnormal urine output (HP:0012590)2.51367955
53Abnormality of the costochondral junction (HP:0000919)2.47749466
54Chronic bronchitis (HP:0004469)2.44623737
55Subcapsular cataract (HP:0000523)2.42008312
56Azoospermia (HP:0000027)2.39163489
57Abnormality of the renal medulla (HP:0100957)2.33999546
58Abnormality of potassium homeostasis (HP:0011042)2.31334381
59Abnormality of the parathyroid morphology (HP:0011766)2.28880631
60Hyperuricemia (HP:0002149)2.27383534
61Increased purine levels (HP:0004368)2.27383534
62Polydipsia (HP:0001959)2.21980940
63Abnormal drinking behavior (HP:0030082)2.21980940
64Abnormality of the pubic bones (HP:0003172)2.19726995
65Progressive hearing impairment (HP:0001730)2.18148845
66Bronchiectasis (HP:0002110)2.16911613
67Abnormality of renal excretion (HP:0011036)2.16135362
68Abnormality of the aortic arch (HP:0012303)2.11303290
69Polyuria (HP:0000103)2.09322303
70Intellectual disability, moderate (HP:0002342)2.06216473
71Focal segmental glomerulosclerosis (HP:0000097)2.04497419
72Recurrent pneumonia (HP:0006532)2.01972183
73Bulbous nose (HP:0000414)2.01413979
74Osteomalacia (HP:0002749)1.98689210
75Congenital sensorineural hearing impairment (HP:0008527)1.96910189
76Optic nerve hypoplasia (HP:0000609)1.96777329
77Renal dysplasia (HP:0000110)1.90988037
78Abnormality of lateral ventricle (HP:0030047)1.90119787
79Myokymia (HP:0002411)1.89880997
80Ventricular tachycardia (HP:0004756)1.87407464
81Sandal gap (HP:0001852)1.83185097
82Hypolipoproteinemia (HP:0010981)1.82722928
83Unilateral renal agenesis (HP:0000122)1.81977956
84Double outlet right ventricle (HP:0001719)1.81161106
85Congenital malformation of the right heart (HP:0011723)1.81161106
86Decreased central vision (HP:0007663)1.79047440
87Photophobia (HP:0000613)1.78688171
88Abnormality of the epiphysis of the femoral head (HP:0010574)1.76761196
89Flattened epiphyses (HP:0003071)1.74944212
90Abnormal albumin level (HP:0012116)1.74077147
91Hypoalbuminemia (HP:0003073)1.74077147
92Hypophosphatemic rickets (HP:0004912)1.72373374
93Transposition of the great arteries (HP:0001669)1.72324137
94Abnormal connection of the cardiac segments (HP:0011545)1.72324137
95Abnormal ventriculo-arterial connection (HP:0011563)1.72324137
96Insulin resistance (HP:0000855)1.72019252
97Widely patent fontanelles and sutures (HP:0004492)1.70916240
98Accelerated skeletal maturation (HP:0005616)1.70754417
99Hyponatremia (HP:0002902)1.70011559
100Convex nasal ridge (HP:0000444)1.69197781

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.96124431
2INSRR4.76289132
3TESK14.36849435
4BRD43.79263384
5DDR23.47017363
6PLK23.36359627
7MAP4K23.29253504
8STK383.24176259
9PNCK3.20671564
10CAMK1G2.43858710
11PRKD32.27334946
12STK38L2.26416871
13PIK3CG2.22595829
14MAPK152.00551821
15WNK11.66595112
16MST1R1.61724553
17LATS11.55854708
18PDK11.42723380
19NEK61.35980040
20PDPK11.34263075
21CDK121.32162500
22TYRO31.26265487
23SIK21.20026030
24DYRK1B1.17736021
25CDK31.06821979
26PTK2B1.03984952
27AKT31.00906435
28MAP3K90.96272240
29TNIK0.94636898
30PINK10.94585072
31CDC42BPA0.89333728
32CDK70.85391228
33CAMK1D0.81486750
34SGK2230.68202640
35SGK4940.68202640
36TAOK30.64537376
37TIE10.64376613
38ROCK10.62554831
39CAMK10.60658282
40TGFBR20.57723778
41PRKG10.55841007
42MAP2K20.54936091
43PRKG20.53489199
44NUAK10.52886747
45BMPR1B0.52097642
46STK390.51544265
47RPS6KA10.50756902
48RPS6KA20.48414466
49BRAF0.48219055
50NEK20.47791724
51PRKAA20.47459435
52SGK20.45958349
53CAMK40.45187106
54FRK0.43546186
55MAP3K110.42212069
56NTRK30.41127240
57MARK10.40827440
58KSR20.40642261
59GSK3B0.39771310
60PRKCG0.39183670
61DMPK0.35390062
62MAPK10.35350359
63CDK20.35310593
64CDK10.34915879
65LATS20.34564366
66MAP3K40.32044659
67ERBB40.31297667
68CAMK2A0.31080114
69MET0.29727099
70MAP3K20.29654244
71SGK10.28311672
72WNK40.27539784
73RPS6KL10.27020706
74RPS6KC10.27020706
75UHMK10.26117731
76PRKCZ0.26096823
77MAPK80.25855151
78MTOR0.25389281
79RPS6KA60.25349884
80BCR0.23610506
81STK30.23446352
82MAP3K80.23240321
83PRKCB0.23197421
84CHEK10.22404922
85MUSK0.21677063
86ACVR1B0.21539963
87MAPK140.21046207
88DYRK30.19719486
89OXSR10.19562001
90SGK30.18826791
91BRSK10.18752171
92TLK10.15977689
93MAP2K70.15198795
94PKN10.13901444
95HCK0.13338931
96MAP3K10.12893127
97MAP3K70.12601814
98MAPK100.12024462
99PRKACB0.10806080
100BRSK20.09343013

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000616.98548506
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.49411834
3Olfactory transduction_Homo sapiens_hsa047403.80855355
4Butanoate metabolism_Homo sapiens_hsa006502.48801515
5Taste transduction_Homo sapiens_hsa047422.18740953
6Glycerophospholipid metabolism_Homo sapiens_hsa005641.95204463
7Fatty acid degradation_Homo sapiens_hsa000711.94890206
8Fatty acid metabolism_Homo sapiens_hsa012121.75866648
9Type II diabetes mellitus_Homo sapiens_hsa049301.70150093
10RNA transport_Homo sapiens_hsa030131.69955332
11Phenylalanine metabolism_Homo sapiens_hsa003601.63614979
12Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.55859171
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.55128248
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54609540
15Dorso-ventral axis formation_Homo sapiens_hsa043201.44853232
16Morphine addiction_Homo sapiens_hsa050321.26760940
17Phototransduction_Homo sapiens_hsa047441.23407247
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.22410499
19Nicotine addiction_Homo sapiens_hsa050331.21883548
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21505610
21ABC transporters_Homo sapiens_hsa020101.19464404
22Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.16039585
23Salivary secretion_Homo sapiens_hsa049701.12966603
24PPAR signaling pathway_Homo sapiens_hsa033201.12187034
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08241880
26Adipocytokine signaling pathway_Homo sapiens_hsa049201.08134104
27Calcium signaling pathway_Homo sapiens_hsa040201.07440417
28Glutamatergic synapse_Homo sapiens_hsa047241.06040841
29Type I diabetes mellitus_Homo sapiens_hsa049400.96881447
30Circadian entrainment_Homo sapiens_hsa047130.96645489
31Hedgehog signaling pathway_Homo sapiens_hsa043400.96633547
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95379307
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94317723
34Nitrogen metabolism_Homo sapiens_hsa009100.93319302
35Protein digestion and absorption_Homo sapiens_hsa049740.92264147
36Primary bile acid biosynthesis_Homo sapiens_hsa001200.91735376
37Endocytosis_Homo sapiens_hsa041440.90521465
38cAMP signaling pathway_Homo sapiens_hsa040240.90304819
39Renin secretion_Homo sapiens_hsa049240.89189077
40Arginine biosynthesis_Homo sapiens_hsa002200.87027936
41Antigen processing and presentation_Homo sapiens_hsa046120.86594558
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84248662
43Autoimmune thyroid disease_Homo sapiens_hsa053200.83178443
44Allograft rejection_Homo sapiens_hsa053300.82067340
45Inositol phosphate metabolism_Homo sapiens_hsa005620.81414543
46Insulin secretion_Homo sapiens_hsa049110.77574291
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76623762
48Viral myocarditis_Homo sapiens_hsa054160.73164284
49Graft-versus-host disease_Homo sapiens_hsa053320.72395405
50Tyrosine metabolism_Homo sapiens_hsa003500.71958863
51Oocyte meiosis_Homo sapiens_hsa041140.71470354
52Retinol metabolism_Homo sapiens_hsa008300.70875796
53Fat digestion and absorption_Homo sapiens_hsa049750.70685251
54Glycerolipid metabolism_Homo sapiens_hsa005610.66129440
55Synaptic vesicle cycle_Homo sapiens_hsa047210.65909544
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.64826237
57VEGF signaling pathway_Homo sapiens_hsa043700.64712424
58Arginine and proline metabolism_Homo sapiens_hsa003300.63805620
59Gastric acid secretion_Homo sapiens_hsa049710.63787298
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62998419
61Influenza A_Homo sapiens_hsa051640.62555878
62Pancreatic secretion_Homo sapiens_hsa049720.61635456
63GABAergic synapse_Homo sapiens_hsa047270.61014660
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60122014
65Serotonergic synapse_Homo sapiens_hsa047260.59140256
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58394295
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58061370
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57035670
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55937385
70Selenocompound metabolism_Homo sapiens_hsa004500.54336645
71Regulation of autophagy_Homo sapiens_hsa041400.53181758
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51283291
73Cardiac muscle contraction_Homo sapiens_hsa042600.50256047
74Cholinergic synapse_Homo sapiens_hsa047250.49958717
75Estrogen signaling pathway_Homo sapiens_hsa049150.48181240
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47825883
77Tight junction_Homo sapiens_hsa045300.47774851
78Adherens junction_Homo sapiens_hsa045200.45944301
79Renin-angiotensin system_Homo sapiens_hsa046140.45764877
80Purine metabolism_Homo sapiens_hsa002300.44548278
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44320652
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43907026
83Vitamin B6 metabolism_Homo sapiens_hsa007500.43114356
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41948363
85Long-term potentiation_Homo sapiens_hsa047200.41783697
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.41627933
87MAPK signaling pathway_Homo sapiens_hsa040100.40774240
88Bile secretion_Homo sapiens_hsa049760.39127154
89Fanconi anemia pathway_Homo sapiens_hsa034600.38013730
90Amphetamine addiction_Homo sapiens_hsa050310.34462777
91Oxytocin signaling pathway_Homo sapiens_hsa049210.33041018
92Propanoate metabolism_Homo sapiens_hsa006400.32593424
93Prolactin signaling pathway_Homo sapiens_hsa049170.29189293
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.26407697
95ECM-receptor interaction_Homo sapiens_hsa045120.26231893
96Gap junction_Homo sapiens_hsa045400.26088733
97Chemical carcinogenesis_Homo sapiens_hsa052040.25774759
98Linoleic acid metabolism_Homo sapiens_hsa005910.24162416
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.22562613
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21679677

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