C3ORF22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm capacitation (GO:0048240)9.64581712
2chromosome condensation (GO:0030261)9.22975272
3DNA packaging (GO:0006323)9.06070806
4spermatid development (GO:0007286)8.27844583
5plasma membrane fusion (GO:0045026)8.08175125
6microtubule depolymerization (GO:0007019)7.91008922
7single strand break repair (GO:0000012)7.90879045
8spermatid nucleus differentiation (GO:0007289)7.73883641
9response to pheromone (GO:0019236)7.59642523
10protein targeting to Golgi (GO:0000042)7.49654950
11protein polyglutamylation (GO:0018095)7.47525919
12rRNA methylation (GO:0031167)7.23720550
13establishment of protein localization to Golgi (GO:0072600)7.20668289
14phosphatidylethanolamine biosynthetic process (GO:0006646)7.16855731
15sperm-egg recognition (GO:0035036)7.14446721
16retrograde transport, vesicle recycling within Golgi (GO:0000301)7.01751080
17multicellular organism reproduction (GO:0032504)6.84435868
18microtubule polymerization or depolymerization (GO:0031109)6.83429872
19phosphatidylethanolamine metabolic process (GO:0046337)6.61304650
20sexual reproduction (GO:0019953)6.55337424
21reproduction (GO:0000003)6.53104617
22calcium ion-dependent exocytosis (GO:0017156)6.38148984
23binding of sperm to zona pellucida (GO:0007339)6.31384477
24negative regulation of inclusion body assembly (GO:0090084)6.30051140
25spermatogenesis (GO:0007283)6.24367811
26male gamete generation (GO:0048232)6.22220047
27microtubule severing (GO:0051013)6.21668919
28centriole replication (GO:0007099)6.19328295
29axonemal dynein complex assembly (GO:0070286)6.12076580
30rRNA modification (GO:0000154)6.07955120
31cell-cell recognition (GO:0009988)5.87682156
32gamete generation (GO:0007276)5.70526994
33regulation of cilium movement (GO:0003352)5.48807844
34centriole assembly (GO:0098534)5.47115169
35protein localization to Golgi apparatus (GO:0034067)5.34018607
36RNA destabilization (GO:0050779)5.18908740
37regulation of Rab GTPase activity (GO:0032313)5.16624019
38positive regulation of Rab GTPase activity (GO:0032851)5.16624019
39cilium or flagellum-dependent cell motility (GO:0001539)5.07842506
40regulation of centriole replication (GO:0046599)5.03448014
41single fertilization (GO:0007338)4.93230864
42cell wall macromolecule catabolic process (GO:0016998)4.92072631
43cellular ketone body metabolic process (GO:0046950)4.84659915
44regulation of transcription involved in cell fate commitment (GO:0060850)4.82794950
45cell wall macromolecule metabolic process (GO:0044036)4.80995128
46motile cilium assembly (GO:0044458)4.79677055
47germ cell development (GO:0007281)4.66783774
48multicellular organismal reproductive process (GO:0048609)4.58493645
49seminiferous tubule development (GO:0072520)4.56906301
50regulation of inclusion body assembly (GO:0090083)4.55394873
51cellular process involved in reproduction in multicellular organism (GO:0022412)4.46645205
52musculoskeletal movement (GO:0050881)4.31885032
53multicellular organismal movement (GO:0050879)4.31885032
54nucleus organization (GO:0006997)4.31062029
55ketone body metabolic process (GO:1902224)4.26333473
56fertilization (GO:0009566)4.24499496
57epithelial cilium movement (GO:0003351)4.19112941
58chromatin silencing (GO:0006342)4.19105056
59regulation of microtubule-based movement (GO:0060632)4.07058963
60organic cation transport (GO:0015695)4.06944811
61microtubule nucleation (GO:0007020)3.77732368
62cilium movement (GO:0003341)3.67661823
63regulation of somitogenesis (GO:0014807)3.59577555
64polyamine biosynthetic process (GO:0006596)3.58421436
65response to acidic pH (GO:0010447)3.52097569
66membrane protein intracellular domain proteolysis (GO:0031293)3.48583514
67cellular response to pH (GO:0071467)3.42681041
68negative regulation of Rho protein signal transduction (GO:0035024)3.40661014
69homeostasis of number of cells within a tissue (GO:0048873)3.36518705
70cerebral cortex neuron differentiation (GO:0021895)3.35253200
71glycerol ether metabolic process (GO:0006662)3.33757767
72antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.32397432
73regulation of interleukin-13 production (GO:0032656)3.28157417
74glomerular visceral epithelial cell development (GO:0072015)3.26703005
75protein-DNA complex disassembly (GO:0032986)3.23456827
76nucleosome disassembly (GO:0006337)3.23456827
77Golgi to endosome transport (GO:0006895)3.23004076
78regulation of T-helper 2 cell differentiation (GO:0045628)3.22745605
79coenzyme catabolic process (GO:0009109)3.21588549
80peptidyl-threonine dephosphorylation (GO:0035970)3.19971965
81glomerular epithelial cell development (GO:0072310)3.15106738
82multicellular organismal development (GO:0007275)3.13739534
83cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.13606564
84histone H3-K9 demethylation (GO:0033169)3.10056744
85ether metabolic process (GO:0018904)3.07061780
86mitotic G1 DNA damage checkpoint (GO:0031571)3.00791905
87protein depolymerization (GO:0051261)2.98611635
88mitochondrial fission (GO:0000266)2.97021604
89regulation of phosphoprotein phosphatase activity (GO:0043666)2.95801719
90nuclear pore complex assembly (GO:0051292)2.91192055
91DNA conformation change (GO:0071103)2.91136399
92RNA localization (GO:0006403)2.88330148
93centrosome duplication (GO:0051298)2.86486006
94positive regulation of guanylate cyclase activity (GO:0031284)2.83122981
95negative regulation of gene expression, epigenetic (GO:0045814)2.82076063
96intra-Golgi vesicle-mediated transport (GO:0006891)2.81149654
97cell recognition (GO:0008037)2.79677996
98sperm motility (GO:0030317)12.2962787
99acrosome reaction (GO:0007340)11.5798036
100fusion of sperm to egg plasma membrane (GO:0007342)10.6822613

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.53170984
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.32944043
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.47968992
4TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.37706019
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.37706019
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.37131306
7VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.21595949
8EZH2_22144423_ChIP-Seq_EOC_Human2.17903884
9IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.14964401
10CBP_20019798_ChIP-Seq_JUKART_Human2.14964401
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09573862
12ELF1_20517297_ChIP-Seq_JURKAT_Human2.05773705
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04253919
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04247985
15DROSHA_22980978_ChIP-Seq_HELA_Human2.03114982
16RAC3_21632823_ChIP-Seq_H3396_Human1.87514056
17ERA_21632823_ChIP-Seq_H3396_Human1.84088823
18EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.82714135
19FUS_26573619_Chip-Seq_HEK293_Human1.82190055
20RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.80711262
21NANOG_20526341_ChIP-Seq_ESCs_Human1.77787279
22CTCF_27219007_Chip-Seq_Bcells_Human1.76203176
23EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.72613499
24WDR5_24793694_ChIP-Seq_LNCAP_Human1.72517610
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71656983
26SMC4_20622854_ChIP-Seq_HELA_Human1.66347397
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62918763
28TAF2_19829295_ChIP-Seq_ESCs_Human1.60832014
29YY1_22570637_ChIP-Seq_MALME-3M_Human1.58260755
30* BCL6_27268052_Chip-Seq_Bcells_Human1.57765742
31BCOR_27268052_Chip-Seq_Bcells_Human1.57078007
32P68_20966046_ChIP-Seq_HELA_Human1.55257596
33MYC_19829295_ChIP-Seq_ESCs_Human1.54283396
34PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.53937223
35E2F1_20622854_ChIP-Seq_HELA_Human1.51772228
36TDRD3_21172665_ChIP-Seq_MCF-7_Human1.51530333
37PHF8_20622854_ChIP-Seq_HELA_Human1.51474071
38ER_23166858_ChIP-Seq_MCF-7_Human1.48751422
39ARNT_22903824_ChIP-Seq_MCF-7_Human1.48494979
40OCT4_20526341_ChIP-Seq_ESCs_Human1.48083718
41CTCF_20526341_ChIP-Seq_ESCs_Human1.46587782
42SMAD4_21741376_ChIP-Seq_EPCs_Human1.45260125
43ERG_20517297_ChIP-Seq_VCAP_Human1.44364501
44* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44211862
45TP63_22573176_ChIP-Seq_HFKS_Human1.42696359
46AUTS2_25519132_ChIP-Seq_293T-REX_Human1.40361887
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38510109
48EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.37736757
49RBPJ_21746931_ChIP-Seq_IB4_Human1.37583676
50SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37055684
51CBX2_22325352_ChIP-Seq_293T-Rex_Human1.36756194
52HNFA_21074721_ChIP-Seq_CACO-2_Human1.36128896
53AR_25329375_ChIP-Seq_VCAP_Human1.35953694
54P300_27268052_Chip-Seq_Bcells_Human1.35410554
55* LXR_22292898_ChIP-Seq_THP-1_Human1.34640836
56CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.33164239
57ETV2_25802403_ChIP-Seq_MESCs_Mouse1.33070193
58CEBPB_22108803_ChIP-Seq_LS180_Human1.31102515
59ETV1_20927104_ChIP-Seq_GIST48_Human1.30353489
60SMAD3_21741376_ChIP-Seq_ESCs_Human1.28562068
61SOX2_22085726_ChIP-Seq_NPCs_Mouse1.28244707
62SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.27084280
63P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.26977274
64ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26736942
65TP53_18474530_ChIP-ChIP_U2OS_Human1.25104449
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.23939393
67KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.23135417
68RUNX1_26923725_Chip-Seq_HPCs_Mouse1.22040965
69SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20373828
70NFYB_21822215_ChIP-Seq_K562_Human1.18838182
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.18575125
72TBL1_22424771_ChIP-Seq_293T_Human1.14164683
73P53_21459846_ChIP-Seq_SAOS-2_Human1.13863321
74SA1_27219007_Chip-Seq_Bcells_Human1.11874292
75P300_19829295_ChIP-Seq_ESCs_Human1.11629827
76PHF8_20622853_ChIP-Seq_HELA_Human1.10158629
77SMRT_27268052_Chip-Seq_Bcells_Human1.10135383
78GATA6_21074721_ChIP-Seq_CACO-2_Human1.09615738
79TAF15_26573619_Chip-Seq_HEK293_Human1.08114875
80PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07805947
81AR_21572438_ChIP-Seq_LNCaP_Human1.07670582
82ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07602472
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06186134
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06160798
85STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05405590
86SMAD4_21741376_ChIP-Seq_HESCs_Human1.03311245
87RUNX_20019798_ChIP-Seq_JUKART_Human1.02675836
88NFYA_21822215_ChIP-Seq_K562_Human1.02180470
89* GATA3_21878914_ChIP-Seq_MCF-7_Human1.01738811
90KLF5_25053715_ChIP-Seq_YYC3_Human1.01605887
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01205472
92PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.00497813
93GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00207480
94EZH2_27294783_Chip-Seq_ESCs_Mouse1.00018313
95SPI1_20517297_ChIP-Seq_HL60_Human0.99263741
96RUNX2_22187159_ChIP-Seq_PCA_Human0.98983491
97KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98858226
98TCF4_18268006_ChIP-ChIP_LS174T_Human0.98431261
99GF1_26923725_Chip-Seq_HPCs_Mouse0.98345254
100FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97170795

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.62719920
2MP0003878_abnormal_ear_physiology5.62719920
3MP0005670_abnormal_white_adipose5.19874588
4MP0003698_abnormal_male_reproductive4.47321121
5MP0001929_abnormal_gametogenesis3.90273246
6MP0001348_abnormal_lacrimal_gland3.21539751
7MP0002161_abnormal_fertility/fecundity2.54492667
8MP0000678_abnormal_parathyroid_gland2.23458237
9MP0003718_maternal_effect2.17356743
10MP0003646_muscle_fatigue2.04687583
11MP0005410_abnormal_fertilization12.3533943
12MP0005451_abnormal_body_composition1.96367645
13MP0002132_abnormal_respiratory_system1.84529352
14MP0002210_abnormal_sex_determination1.76529685
15MP0001485_abnormal_pinna_reflex1.72581196
16MP0005423_abnormal_somatic_nervous1.62088774
17MP0005379_endocrine/exocrine_gland_phen1.61854725
18MP0002822_catalepsy1.61235187
19MP0005310_abnormal_salivary_gland1.58072924
20MP0003011_delayed_dark_adaptation1.47324282
21MP0001145_abnormal_male_reproductive1.44467793
22MP0002234_abnormal_pharynx_morphology1.43484285
23MP0002249_abnormal_larynx_morphology1.39923740
24MP0001486_abnormal_startle_reflex1.38445024
25MP0003879_abnormal_hair_cell1.38170054
26MP0000653_abnormal_sex_gland1.37983557
27MP0002282_abnormal_trachea_morphology1.33349411
28MP0009053_abnormal_anal_canal1.24995937
29MP0002138_abnormal_hepatobiliary_system1.20166691
30MP0004742_abnormal_vestibular_system1.18030337
31MP0004859_abnormal_synaptic_plasticity1.14396886
32MP0000534_abnormal_ureter_morphology1.12198271
33MP0001765_abnormal_ion_homeostasis1.10150786
34MP0001963_abnormal_hearing_physiology1.08376184
35MP0009115_abnormal_fat_cell1.05988350
36MP0005395_other_phenotype1.00465510
37MP0002127_abnormal_cardiovascular_syste0.99373850
38MP0005666_abnormal_adipose_tissue0.99138618
39MP0002735_abnormal_chemical_nociception0.98692198
40MP0000026_abnormal_inner_ear0.90594622
41MP0002229_neurodegeneration0.87383564
42MP0001968_abnormal_touch/_nociception0.87210851
43MP0005248_abnormal_Harderian_gland0.87054113
44MP0000955_abnormal_spinal_cord0.86950022
45MP0004510_myositis0.86524222
46MP0005551_abnormal_eye_electrophysiolog0.85055131
47MP0001666_abnormal_nutrient_absorption0.80128627
48MP0008569_lethality_at_weaning0.78200685
49MP0005375_adipose_tissue_phenotype0.75263110
50MP0005083_abnormal_biliary_tract0.74042821
51MP0002067_abnormal_sensory_capabilities0.71878869
52MP0001905_abnormal_dopamine_level0.71358672
53MP0000681_abnormal_thyroid_gland0.69588386
54MP0002557_abnormal_social/conspecific_i0.66298135
55MP0005253_abnormal_eye_physiology0.65848586
56MP0008877_abnormal_DNA_methylation0.65273858
57MP0005167_abnormal_blood-brain_barrier0.65243020
58MP0009697_abnormal_copulation0.64146157
59MP0010329_abnormal_lipoprotein_level0.62544016
60MP0005636_abnormal_mineral_homeostasis0.61860382
61MP0004085_abnormal_heartbeat0.56647876
62MP0003077_abnormal_cell_cycle0.55470070
63MP0000003_abnormal_adipose_tissue0.54853615
64MP0004233_abnormal_muscle_weight0.54489514
65MP0000049_abnormal_middle_ear0.52056804
66MP0001440_abnormal_grooming_behavior0.49552367
67MP0004484_altered_response_of0.48895684
68MP0001879_abnormal_lymphatic_vessel0.48334765
69MP0002572_abnormal_emotion/affect_behav0.46937239
70MP0000516_abnormal_urinary_system0.46814251
71MP0005367_renal/urinary_system_phenotyp0.46814251
72MP0000249_abnormal_blood_vessel0.46699817
73MP0002733_abnormal_thermal_nociception0.46319918
74MP0005647_abnormal_sex_gland0.45894293
75MP0005535_abnormal_body_temperature0.45600750
76MP0003699_abnormal_female_reproductive0.45048235
77MP0003631_nervous_system_phenotype0.42662808
78MP0003137_abnormal_impulse_conducting0.42274574
79MP0004036_abnormal_muscle_relaxation0.41235551
80MP0002272_abnormal_nervous_system0.40597608
81MP0002928_abnormal_bile_duct0.40255056
82MP0005408_hypopigmentation0.39689511
83MP0009745_abnormal_behavioral_response0.39339226
84MP0001270_distended_abdomen0.38845949
85MP0008961_abnormal_basal_metabolism0.37795327
86MP0005084_abnormal_gallbladder_morpholo0.37140524
87MP0000613_abnormal_salivary_gland0.37116620
88MP0002734_abnormal_mechanical_nocicepti0.36829830
89MP0003632_abnormal_nervous_system0.36126843
90MP0001545_abnormal_hematopoietic_system0.35788514
91MP0005397_hematopoietic_system_phenotyp0.35788514
92MP0008995_early_reproductive_senescence0.35108050
93MP0001984_abnormal_olfaction0.34494291
94MP0005332_abnormal_amino_acid0.34182858
95MP0000230_abnormal_systemic_arterial0.33476855
96MP0009764_decreased_sensitivity_to0.33139200
97MP0000470_abnormal_stomach_morphology0.31818395
98MP0003633_abnormal_nervous_system0.31756953
99MP0005391_vision/eye_phenotype0.31573505
100MP0003091_abnormal_cell_migration0.31434930

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.68528437
2Tubulointerstitial nephritis (HP:0001970)5.92248557
3Absent/shortened dynein arms (HP:0200106)5.88630032
4Dynein arm defect of respiratory motile cilia (HP:0012255)5.88630032
5Asymmetric septal hypertrophy (HP:0001670)5.84187374
6Chronic hepatic failure (HP:0100626)5.52461293
7Hyperkalemia (HP:0002153)4.86546355
8Bony spicule pigmentary retinopathy (HP:0007737)4.76097823
9Attenuation of retinal blood vessels (HP:0007843)4.75763357
10Resting tremor (HP:0002322)4.69002461
11Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.62529327
12Male infertility (HP:0003251)4.48869959
13Abnormal ciliary motility (HP:0012262)4.46318747
14Abnormal respiratory motile cilium physiology (HP:0012261)4.41819444
15Cone-rod dystrophy (HP:0000548)4.28293516
16Abnormal respiratory epithelium morphology (HP:0012253)4.18827719
17Abnormal respiratory motile cilium morphology (HP:0005938)4.18827719
18Nasal polyposis (HP:0100582)4.17989808
19Abnormality of macular pigmentation (HP:0008002)4.17987619
20Infertility (HP:0000789)4.13646634
21Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.04656731
22Facial shape deformation (HP:0011334)4.03250377
23Potter facies (HP:0002009)4.03250377
24Bell-shaped thorax (HP:0001591)4.00722004
25Hypoalphalipoproteinemia (HP:0003233)3.82641324
26Aplasia/Hypoplasia of the earlobes (HP:0009906)3.73510500
27Hypoplasia of the thymus (HP:0000778)3.69804440
28Impulsivity (HP:0100710)3.69257861
29Progressive sensorineural hearing impairment (HP:0000408)3.44254027
30Abnormality of the nasal mucosa (HP:0000433)3.40677505
31Abnormal rod and cone electroretinograms (HP:0008323)3.35407093
32Menstrual irregularities (HP:0000858)3.29452774
33Postural instability (HP:0002172)3.25632396
34Hypoplastic ischia (HP:0003175)3.21907752
35Enlarged epiphyses (HP:0010580)3.18150406
36Amelogenesis imperfecta (HP:0000705)3.18065622
37Abnormal spermatogenesis (HP:0008669)3.13646348
38Renovascular hypertension (HP:0100817)3.05704470
39Truncal obesity (HP:0001956)2.97418609
40Portal hypertension (HP:0001409)2.96013502
41Abnormality of the ischium (HP:0003174)2.91003367
42Azoospermia (HP:0000027)2.85140047
43Abnormality of dental color (HP:0011073)2.84861821
44Abnormal urine output (HP:0012590)2.83554539
45Progressive cerebellar ataxia (HP:0002073)2.82762071
46Insulin-resistant diabetes mellitus (HP:0000831)2.79989977
47Tubulointerstitial abnormality (HP:0001969)2.79640556
48Generalized aminoaciduria (HP:0002909)2.76244024
49Abnormality of the hepatic vasculature (HP:0006707)2.74072438
50Nephronophthisis (HP:0000090)2.74008106
51Rhinitis (HP:0012384)2.67442167
52Abnormality of potassium homeostasis (HP:0011042)2.67284940
53Abnormality of the costochondral junction (HP:0000919)2.66856095
54Stage 5 chronic kidney disease (HP:0003774)2.63282682
55Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.58733591
56Abnormality of the aortic arch (HP:0012303)2.56821879
57Unilateral renal agenesis (HP:0000122)2.55591506
58Double outlet right ventricle (HP:0001719)2.51314839
59Congenital malformation of the right heart (HP:0011723)2.51314839
60Abnormality of renal excretion (HP:0011036)2.43054893
61Abnormal drinking behavior (HP:0030082)2.41182168
62Polydipsia (HP:0001959)2.41182168
63Renal dysplasia (HP:0000110)2.36402704
64Increased purine levels (HP:0004368)2.33334614
65Hyperuricemia (HP:0002149)2.33334614
66Abnormality of the renal medulla (HP:0100957)2.31493741
67Ventricular tachycardia (HP:0004756)2.30308972
68Hypophosphatemic rickets (HP:0004912)2.25309307
69Progressive hearing impairment (HP:0001730)2.22274424
70Polyuria (HP:0000103)2.19425357
71Widely patent fontanelles and sutures (HP:0004492)2.18410509
72Osteomalacia (HP:0002749)2.14969504
73Abnormality of the parathyroid morphology (HP:0011766)2.13872482
74Epiphyseal dysplasia (HP:0002656)2.13095884
75Subcapsular cataract (HP:0000523)2.13055777
76Hypolipoproteinemia (HP:0010981)2.05108356
77Recurrent pneumonia (HP:0006532)2.04052861
78Myokymia (HP:0002411)2.03383507
79Chronic bronchitis (HP:0004469)2.01382323
80Intellectual disability, moderate (HP:0002342)2.01304443
81Renal Fanconi syndrome (HP:0001994)1.98322028
82Hyponatremia (HP:0002902)1.96285827
83Flattened epiphyses (HP:0003071)1.93147635
84Bronchiectasis (HP:0002110)1.90961148
85Focal segmental glomerulosclerosis (HP:0000097)1.84594268
86Bradycardia (HP:0001662)1.79622671
87Tetany (HP:0001281)1.79100868
88Recurrent corneal erosions (HP:0000495)1.78590773
89Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.77586901
90Absent epiphyses (HP:0010577)1.77586901
91Abnormality of the epiphysis of the femoral head (HP:0010574)1.77268505
92Decreased central vision (HP:0007663)1.75582683
93Transposition of the great arteries (HP:0001669)1.75064661
94Abnormal connection of the cardiac segments (HP:0011545)1.75064661
95Abnormal ventriculo-arterial connection (HP:0011563)1.75064661
96Abnormality of chloride homeostasis (HP:0011422)1.72626627
97Insulin resistance (HP:0000855)1.72410830
98Aplasia/Hypoplasia of the sacrum (HP:0008517)1.68155550
99Abnormality of urine glucose concentration (HP:0011016)1.66753001
100Glycosuria (HP:0003076)1.66753001

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.90825331
2TESK15.99858950
3DDR24.19809273
4INSRR3.75002878
5BRD43.40862287
6STK383.33805209
7PNCK3.31374624
8PLK23.25865241
9CAMK1G2.67266810
10MAPK152.56463338
11PRKD32.42624590
12STK38L2.35918240
13MAP4K22.31593566
14PIK3CG1.92296754
15MST1R1.74396374
16PDPK11.73335339
17PDK11.62588441
18CDK121.55746673
19NEK61.48462182
20DYRK1B1.45949352
21WNK11.41520369
22CDK71.22160455
23TYRO31.18847605
24PTK2B1.12230402
25AKT31.11538479
26CAMK1D1.05743602
27SIK20.94564767
28KSR20.92524250
29WNK40.85508728
30MAP3K110.81198903
31PRKG20.72126413
32LATS10.70179295
33BRAF0.67390404
34MAP3K90.66929037
35PRKG10.64590589
36RPS6KA20.64242599
37STK390.63730769
38MAP2K20.61631932
39RPS6KA10.60830103
40LATS20.60818652
41MAP3K20.60514060
42UHMK10.56024381
43RIPK40.55622394
44PRKAA20.54601885
45CAMK10.54419488
46SGK2230.51912894
47SGK4940.51912894
48TESK20.49176109
49CDK20.46494036
50ROCK10.46374410
51GSK3B0.45072960
52CDK30.43448400
53MAP3K80.43116290
54MAPK10.42321422
55CDK10.41712888
56MTOR0.39084144
57MAP3K10.38221920
58MAPK80.36285091
59TIE10.35173862
60BMPR1B0.35099737
61RPS6KC10.34972102
62RPS6KL10.34972102
63SGK10.34093606
64CDK40.33908466
65JAK30.32977991
66CAMK40.32191481
67MARK10.31781176
68RPS6KA60.31059794
69PRKCZ0.30197516
70NTRK30.28085986
71PRKCG0.28035318
72BRSK10.27234753
73MUSK0.26825449
74CHEK10.26473630
75PRKCB0.24548789
76MAPK140.24333572
77BLK0.23184506
78MAPK110.22864450
79MAPK100.21137266
80OXSR10.20807234
81MARK20.20451899
82MET0.19943556
83SGK20.16369225
84ARAF0.15654848
85AKT10.15300603
86ICK0.14761269
87MAP3K40.14543736
88NEK20.12608968
89PRKACB0.12073326
90FER0.11160946
91PKN10.08736755
92BRSK20.08579250
93SGK30.08317014
94PRKACA0.07857298
95PRKAA10.07804521
96ACVR1B0.06236047
97RIPK10.04950216
98MINK10.04701107
99RPS6KA30.04180787
100MAPK90.04052077

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000617.72612809
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.71934200
3Olfactory transduction_Homo sapiens_hsa047403.44284990
4Butanoate metabolism_Homo sapiens_hsa006502.32937238
5Fatty acid degradation_Homo sapiens_hsa000712.26658535
6Glycerophospholipid metabolism_Homo sapiens_hsa005642.19272694
7Fatty acid metabolism_Homo sapiens_hsa012121.97216218
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.95508483
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90842257
10Dorso-ventral axis formation_Homo sapiens_hsa043201.75534852
11Phenylalanine metabolism_Homo sapiens_hsa003601.64617525
12Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.60785224
13Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.58110044
14Taste transduction_Homo sapiens_hsa047421.56495518
15Type II diabetes mellitus_Homo sapiens_hsa049301.54419595
16Adipocytokine signaling pathway_Homo sapiens_hsa049201.52879782
17RNA transport_Homo sapiens_hsa030131.51888917
18Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.39785774
19PPAR signaling pathway_Homo sapiens_hsa033201.36623922
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17982293
21Type I diabetes mellitus_Homo sapiens_hsa049401.14917506
22Arginine biosynthesis_Homo sapiens_hsa002201.12541323
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.06886070
24Antigen processing and presentation_Homo sapiens_hsa046121.05571076
25Endocytosis_Homo sapiens_hsa041441.02026907
26ABC transporters_Homo sapiens_hsa020101.01473591
27Inositol phosphate metabolism_Homo sapiens_hsa005621.00241064
28Arginine and proline metabolism_Homo sapiens_hsa003301.00213475
29Protein digestion and absorption_Homo sapiens_hsa049740.99965030
30Synaptic vesicle cycle_Homo sapiens_hsa047210.99579881
31Phototransduction_Homo sapiens_hsa047440.98913362
32Allograft rejection_Homo sapiens_hsa053300.98590184
33Autoimmune thyroid disease_Homo sapiens_hsa053200.97386197
34Fat digestion and absorption_Homo sapiens_hsa049750.90562596
35Graft-versus-host disease_Homo sapiens_hsa053320.86760544
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86468141
37Salivary secretion_Homo sapiens_hsa049700.86340543
38Morphine addiction_Homo sapiens_hsa050320.86186823
39Renin-angiotensin system_Homo sapiens_hsa046140.84911093
40Calcium signaling pathway_Homo sapiens_hsa040200.82463031
41Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78674351
42Tyrosine metabolism_Homo sapiens_hsa003500.77881488
43Glycerolipid metabolism_Homo sapiens_hsa005610.77330523
44cAMP signaling pathway_Homo sapiens_hsa040240.77223508
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76763321
46Hedgehog signaling pathway_Homo sapiens_hsa043400.76022929
47Viral myocarditis_Homo sapiens_hsa054160.73353599
48Selenocompound metabolism_Homo sapiens_hsa004500.70155189
49Circadian entrainment_Homo sapiens_hsa047130.69901878
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69887042
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68761936
52Influenza A_Homo sapiens_hsa051640.65822075
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65725968
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65092348
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.64820893
56Bile secretion_Homo sapiens_hsa049760.63963360
57Oocyte meiosis_Homo sapiens_hsa041140.62572858
58Cardiac muscle contraction_Homo sapiens_hsa042600.62473505
59Retinol metabolism_Homo sapiens_hsa008300.60734154
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60418725
61Estrogen signaling pathway_Homo sapiens_hsa049150.58906043
62Nicotine addiction_Homo sapiens_hsa050330.58756637
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58612085
64Glutamatergic synapse_Homo sapiens_hsa047240.57803503
65Renin secretion_Homo sapiens_hsa049240.51760091
66VEGF signaling pathway_Homo sapiens_hsa043700.51159893
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50929140
68Gastric acid secretion_Homo sapiens_hsa049710.48841853
69Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47346788
70Biosynthesis of amino acids_Homo sapiens_hsa012300.45654655
71Acute myeloid leukemia_Homo sapiens_hsa052210.44458515
72Tight junction_Homo sapiens_hsa045300.42555388
73Serotonergic synapse_Homo sapiens_hsa047260.41357591
74Purine metabolism_Homo sapiens_hsa002300.40492236
75MAPK signaling pathway_Homo sapiens_hsa040100.40301856
76Pancreatic secretion_Homo sapiens_hsa049720.38386170
77Nitrogen metabolism_Homo sapiens_hsa009100.37875431
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.35635352
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34466723
80Cholinergic synapse_Homo sapiens_hsa047250.33843570
81Insulin secretion_Homo sapiens_hsa049110.29822135
82Long-term potentiation_Homo sapiens_hsa047200.29120749
83GABAergic synapse_Homo sapiens_hsa047270.25775377
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23837974
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23703035
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.22998978
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22130247
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.21803974
89ECM-receptor interaction_Homo sapiens_hsa045120.21167896
90Prolactin signaling pathway_Homo sapiens_hsa049170.20982359
91Oxytocin signaling pathway_Homo sapiens_hsa049210.20789860
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.19114686
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.18981554
94Viral carcinogenesis_Homo sapiens_hsa052030.16515563
95Metabolic pathways_Homo sapiens_hsa011000.16062579
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.15208944
97mRNA surveillance pathway_Homo sapiens_hsa030150.15083692
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.15069691
99Basal transcription factors_Homo sapiens_hsa030220.14979672
100Huntingtons disease_Homo sapiens_hsa050160.14532095

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