C3ORF14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)4.31655632
2presynaptic membrane organization (GO:0097090)3.92793383
3neuron cell-cell adhesion (GO:0007158)3.65639565
4neurotransmitter-gated ion channel clustering (GO:0072578)3.61143631
5pyrimidine nucleobase catabolic process (GO:0006208)3.42704194
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.39726177
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.37612303
8postsynaptic membrane organization (GO:0001941)3.29636980
9protein complex biogenesis (GO:0070271)3.26567635
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.13731908
11nonmotile primary cilium assembly (GO:0035058)3.12688712
12nucleobase catabolic process (GO:0046113)3.10830244
13axonal fasciculation (GO:0007413)3.06760853
14protein localization to cilium (GO:0061512)3.01777491
15behavioral response to nicotine (GO:0035095)2.99988674
16mitochondrial respiratory chain complex assembly (GO:0033108)2.99323546
17protein neddylation (GO:0045116)2.95457819
18protein localization to synapse (GO:0035418)2.92856455
19water-soluble vitamin biosynthetic process (GO:0042364)2.92374075
20vocalization behavior (GO:0071625)2.87750984
21regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.85905751
22regulation of glucokinase activity (GO:0033131)2.85284495
23regulation of hexokinase activity (GO:1903299)2.85284495
24neuron fate determination (GO:0048664)2.84214309
25glycosphingolipid biosynthetic process (GO:0006688)2.81873655
26auditory behavior (GO:0031223)2.81832742
27retinal ganglion cell axon guidance (GO:0031290)2.81534535
28dendritic spine morphogenesis (GO:0060997)2.80213752
29cullin deneddylation (GO:0010388)2.79202595
30inositol phosphate catabolic process (GO:0071545)2.77847505
31neuron recognition (GO:0008038)2.75532985
32respiratory chain complex IV assembly (GO:0008535)2.75509348
33NADH dehydrogenase complex assembly (GO:0010257)2.72618447
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.72618447
35mitochondrial respiratory chain complex I assembly (GO:0032981)2.72618447
36ATP synthesis coupled proton transport (GO:0015986)2.72378843
37energy coupled proton transport, down electrochemical gradient (GO:0015985)2.72378843
38electron transport chain (GO:0022900)2.70004118
39respiratory electron transport chain (GO:0022904)2.68328421
40transmission of nerve impulse (GO:0019226)2.68038718
41synapse assembly (GO:0007416)2.67237227
42G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.66975521
43neuronal action potential propagation (GO:0019227)2.66927437
44substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.66512414
45substrate-independent telencephalic tangential migration (GO:0021826)2.66512414
46glutamate receptor signaling pathway (GO:0007215)2.66511580
47gamma-aminobutyric acid transport (GO:0015812)2.66311087
48DNA double-strand break processing (GO:0000729)2.65731883
49ionotropic glutamate receptor signaling pathway (GO:0035235)2.65024245
50regulation of short-term neuronal synaptic plasticity (GO:0048172)2.61026775
51regulation of cilium movement (GO:0003352)2.59255556
52detection of calcium ion (GO:0005513)2.58983503
53establishment of protein localization to mitochondrial membrane (GO:0090151)2.58332195
54startle response (GO:0001964)2.58052424
55neurotransmitter secretion (GO:0007269)2.55992645
56protein deneddylation (GO:0000338)2.55187473
57synaptic vesicle maturation (GO:0016188)2.54886305
58protein-cofactor linkage (GO:0018065)2.53898236
59synaptic transmission, glutamatergic (GO:0035249)2.53092409
60neuron-neuron synaptic transmission (GO:0007270)2.52040308
61regulation of action potential (GO:0098900)2.51234288
62intraciliary transport (GO:0042073)2.50691985
63cellular ketone body metabolic process (GO:0046950)2.49518661
64epithelial cilium movement (GO:0003351)2.47944107
65response to pheromone (GO:0019236)2.46234446
66negative regulation of dendrite development (GO:2000171)2.45915409
67mechanosensory behavior (GO:0007638)2.45682690
68proteasome assembly (GO:0043248)2.44564234
69cytochrome complex assembly (GO:0017004)2.44392454
70positive regulation of mitochondrial fission (GO:0090141)2.40303970
71limb bud formation (GO:0060174)2.39858661
72cilium morphogenesis (GO:0060271)2.39743368
73establishment of melanosome localization (GO:0032401)2.37432150
74platelet dense granule organization (GO:0060155)2.35544188
75melanosome transport (GO:0032402)2.35405589
76glutamate secretion (GO:0014047)2.35084529
77positive regulation of action potential (GO:0045760)2.34360229
78negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.32547553
79neural tube formation (GO:0001841)2.30405704
80retinal cone cell development (GO:0046549)2.30014849
81keratinocyte development (GO:0003334)2.29602599
82response to amphetamine (GO:0001975)2.28755520
83cilium assembly (GO:0042384)2.28271336
84positive regulation of amino acid transport (GO:0051957)2.27070596
85regulation of calcium ion-dependent exocytosis (GO:0017158)2.26470654
86glycerophospholipid catabolic process (GO:0046475)2.26444445
87peptidyl-histidine modification (GO:0018202)2.26407150
88neuronal action potential (GO:0019228)2.25597172
89cilium organization (GO:0044782)2.25448827
90establishment of pigment granule localization (GO:0051905)2.25254588
91regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.24632856
92proline transport (GO:0015824)2.23933182
93negative regulation of synaptic transmission, GABAergic (GO:0032229)2.23087177
94energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.22882082
95ATP hydrolysis coupled proton transport (GO:0015991)2.22882082
96pigment granule transport (GO:0051904)2.22766618
97reflex (GO:0060004)2.22305431
98calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.22141306
99neuron fate specification (GO:0048665)2.21941185
100regulation of timing of cell differentiation (GO:0048505)2.21690719

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.12454499
2GBX2_23144817_ChIP-Seq_PC3_Human3.03119465
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.92039628
4ZNF274_21170338_ChIP-Seq_K562_Hela2.89744081
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.80686297
6* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.71939621
7TAF15_26573619_Chip-Seq_HEK293_Human2.51934188
8VDR_22108803_ChIP-Seq_LS180_Human2.39532430
9FUS_26573619_Chip-Seq_HEK293_Human2.36445564
10IGF1R_20145208_ChIP-Seq_DFB_Human2.34202130
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.33633195
12EZH2_22144423_ChIP-Seq_EOC_Human2.29708974
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.28626751
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10780620
15EWS_26573619_Chip-Seq_HEK293_Human2.04403780
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.03426903
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.03377834
18* P300_19829295_ChIP-Seq_ESCs_Human2.03188725
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02552379
20SALL1_21062744_ChIP-ChIP_HESCs_Human1.95319911
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93976539
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.90631531
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80156211
24SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76644542
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.76200099
26REST_21632747_ChIP-Seq_MESCs_Mouse1.75744552
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.75102703
28* ER_23166858_ChIP-Seq_MCF-7_Human1.73638351
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73276133
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.70847519
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70286999
32SMAD4_21799915_ChIP-Seq_A2780_Human1.67272440
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61799325
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59622846
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56789750
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55805757
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.52542723
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.49829681
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49452977
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49289984
41RNF2_27304074_Chip-Seq_NSC_Mouse1.48018613
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47894065
43* AR_25329375_ChIP-Seq_VCAP_Human1.44763310
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.40518968
45* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39231497
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39165998
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.37249459
48* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37164242
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37143399
50ELK1_19687146_ChIP-ChIP_HELA_Human1.35991842
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35985884
52SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35496553
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34640185
54BCAT_22108803_ChIP-Seq_LS180_Human1.34267828
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.33744792
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.33050733
57RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29201831
58TP53_22573176_ChIP-Seq_HFKS_Human1.27938712
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26677097
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24634329
61CBP_20019798_ChIP-Seq_JUKART_Human1.24634329
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20859458
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20859458
64EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20783848
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19774544
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19008378
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17697554
68CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.17380364
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16966030
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16463243
71* STAT3_23295773_ChIP-Seq_U87_Human1.16148748
72HTT_18923047_ChIP-ChIP_STHdh_Human1.16003124
73TCF4_23295773_ChIP-Seq_U87_Human1.14976401
74MYC_18940864_ChIP-ChIP_HL60_Human1.14517316
75P53_22387025_ChIP-Seq_ESCs_Mouse1.13813718
76FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11037252
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11031144
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10425700
79TCF4_22108803_ChIP-Seq_LS180_Human1.09908549
80JARID2_20064375_ChIP-Seq_MESCs_Mouse1.09239945
81RUNX2_22187159_ChIP-Seq_PCA_Human1.08336134
82SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.07049332
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07030078
84NFE2_27457419_Chip-Seq_LIVER_Mouse1.06382516
85* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05310274
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05229890
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.05029674
88TAL1_26923725_Chip-Seq_HPCs_Mouse1.03749943
89EED_16625203_ChIP-ChIP_MESCs_Mouse1.03526347
90FLI1_21867929_ChIP-Seq_TH2_Mouse1.03310541
91PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03117199
92ETS1_20019798_ChIP-Seq_JURKAT_Human1.03096532
93NANOG_19829295_ChIP-Seq_ESCs_Human1.02024126
94SOX2_19829295_ChIP-Seq_ESCs_Human1.02024126
95CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01213596
96E2F1_18555785_Chip-Seq_ESCs_Mouse1.00647410
97CMYC_18555785_Chip-Seq_ESCs_Mouse1.00038578
98SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99607224
99JUN_21703547_ChIP-Seq_K562_Human0.97740206
100SOX2_21211035_ChIP-Seq_LN229_Gbm0.97604294

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.82253090
2MP0004270_analgesia2.95860716
3MP0003787_abnormal_imprinting2.85113097
4MP0001529_abnormal_vocalization2.71116011
5MP0009046_muscle_twitch2.44678468
6MP0002837_dystrophic_cardiac_calcinosis2.33526304
7MP0001968_abnormal_touch/_nociception2.29770539
8MP0003122_maternal_imprinting2.22695325
9MP0008877_abnormal_DNA_methylation2.21624235
10MP0009745_abnormal_behavioral_response2.11902487
11MP0002736_abnormal_nociception_after2.09674280
12MP0002909_abnormal_adrenal_gland2.09539614
13MP0002102_abnormal_ear_morphology2.08767876
14MP0001984_abnormal_olfaction2.03597855
15MP0002272_abnormal_nervous_system2.02476259
16MP0006276_abnormal_autonomic_nervous2.00311845
17MP0009780_abnormal_chondrocyte_physiolo1.98308248
18MP0004859_abnormal_synaptic_plasticity1.96299199
19MP0006072_abnormal_retinal_apoptosis1.94923341
20MP0003635_abnormal_synaptic_transmissio1.88670200
21MP0002638_abnormal_pupillary_reflex1.87037014
22MP0002734_abnormal_mechanical_nocicepti1.84968450
23MP0003121_genomic_imprinting1.84551641
24MP0002064_seizures1.77003643
25MP0001486_abnormal_startle_reflex1.76328943
26MP0000778_abnormal_nervous_system1.70060235
27MP0010386_abnormal_urinary_bladder1.68306869
28MP0005646_abnormal_pituitary_gland1.68183093
29MP0002572_abnormal_emotion/affect_behav1.65277342
30MP0002063_abnormal_learning/memory/cond1.64367111
31MP0003195_calcinosis1.60619935
32MP0008789_abnormal_olfactory_epithelium1.60607973
33MP0000569_abnormal_digit_pigmentation1.56722429
34MP0005551_abnormal_eye_electrophysiolog1.54904518
35MP0003011_delayed_dark_adaptation1.54774733
36MP0005253_abnormal_eye_physiology1.53900799
37MP0002735_abnormal_chemical_nociception1.52804443
38MP0002184_abnormal_innervation1.50525023
39MP0002557_abnormal_social/conspecific_i1.49958087
40MP0002822_catalepsy1.47010150
41MP0005379_endocrine/exocrine_gland_phen1.43660358
42MP0002751_abnormal_autonomic_nervous1.43626306
43MP0005499_abnormal_olfactory_system1.38581976
44MP0005394_taste/olfaction_phenotype1.38581976
45MP0005386_behavior/neurological_phenoty1.38443836
46MP0004924_abnormal_behavior1.38443836
47MP0005084_abnormal_gallbladder_morpholo1.37653547
48MP0005423_abnormal_somatic_nervous1.35455966
49MP0000631_abnormal_neuroendocrine_gland1.34534797
50MP0004133_heterotaxia1.33906772
51MP0002067_abnormal_sensory_capabilities1.33085262
52MP0001905_abnormal_dopamine_level1.32382191
53MP0004885_abnormal_endolymph1.32153542
54MP0001970_abnormal_pain_threshold1.31306320
55MP0005645_abnormal_hypothalamus_physiol1.29914062
56MP0006292_abnormal_olfactory_placode1.27645173
57MP0004142_abnormal_muscle_tone1.27507026
58MP0002938_white_spotting1.20430541
59MP0001485_abnormal_pinna_reflex1.18488415
60MP0003123_paternal_imprinting1.17899376
61MP0004043_abnormal_pH_regulation1.16683141
62MP0001188_hyperpigmentation1.15185974
63MP0005187_abnormal_penis_morphology1.14194270
64MP0002163_abnormal_gland_morphology1.13690611
65MP0001501_abnormal_sleep_pattern1.12392212
66MP0002733_abnormal_thermal_nociception1.11764681
67MP0002234_abnormal_pharynx_morphology1.11149720
68MP0000427_abnormal_hair_cycle1.09761963
69MP0001944_abnormal_pancreas_morphology1.09077773
70MP0002882_abnormal_neuron_morphology1.08673654
71MP0000955_abnormal_spinal_cord1.08342754
72MP0004147_increased_porphyrin_level1.03623490
73MP0004742_abnormal_vestibular_system1.02589318
74MP0002653_abnormal_ependyma_morphology1.01176909
75MP0008995_early_reproductive_senescence0.98387768
76MP0002090_abnormal_vision0.98336827
77MP0000538_abnormal_urinary_bladder0.97428094
78MP0000516_abnormal_urinary_system0.97303937
79MP0005367_renal/urinary_system_phenotyp0.97303937
80MP0004811_abnormal_neuron_physiology0.95898616
81MP0008872_abnormal_physiological_respon0.95854475
82MP0002752_abnormal_somatic_nervous0.95193615
83MP0003890_abnormal_embryonic-extraembry0.95003263
84MP0002928_abnormal_bile_duct0.94705358
85MP0008058_abnormal_DNA_repair0.93367731
86MP0000647_abnormal_sebaceous_gland0.91831160
87MP0003718_maternal_effect0.90612496
88MP0002160_abnormal_reproductive_system0.90407766
89MP0002066_abnormal_motor_capabilities/c0.87935210
90MP0002229_neurodegeneration0.87384593
91MP0003283_abnormal_digestive_organ0.85638898
92MP0002069_abnormal_eating/drinking_beha0.85574363
93MP0005248_abnormal_Harderian_gland0.83022010
94MP0001440_abnormal_grooming_behavior0.82402207
95MP0002693_abnormal_pancreas_physiology0.82238137
96MP0004215_abnormal_myocardial_fiber0.80911629
97MP0002152_abnormal_brain_morphology0.80616945
98MP0003137_abnormal_impulse_conducting0.79806730
99MP0000372_irregular_coat_pigmentation0.78610692
100MP0003119_abnormal_digestive_system0.77340905

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.52971263
2Progressive macrocephaly (HP:0004481)3.40414929
3Medial flaring of the eyebrow (HP:0010747)3.34827413
4Hypothermia (HP:0002045)3.19650741
5Gait imbalance (HP:0002141)3.09290373
6Abnormal mitochondria in muscle tissue (HP:0008316)3.06303370
7Limb dystonia (HP:0002451)3.03052967
8Acute encephalopathy (HP:0006846)3.00968031
9Pancreatic cysts (HP:0001737)2.88843155
10Pancreatic fibrosis (HP:0100732)2.87821646
11Mitochondrial inheritance (HP:0001427)2.86425392
12Focal motor seizures (HP:0011153)2.86286122
13Febrile seizures (HP:0002373)2.85001856
14Congenital primary aphakia (HP:0007707)2.84865312
15Hyperventilation (HP:0002883)2.83773209
16Myokymia (HP:0002411)2.80377350
17Molar tooth sign on MRI (HP:0002419)2.78253733
18Abnormality of midbrain morphology (HP:0002418)2.78253733
19True hermaphroditism (HP:0010459)2.75891343
20Abnormality of the labia minora (HP:0012880)2.70733325
21Methylmalonic acidemia (HP:0002912)2.70198004
22Nephrogenic diabetes insipidus (HP:0009806)2.67779346
23Increased CSF lactate (HP:0002490)2.64241726
24Hepatic necrosis (HP:0002605)2.63195845
25Agitation (HP:0000713)2.59923080
26Broad-based gait (HP:0002136)2.54378151
27Focal seizures (HP:0007359)2.48407965
28Nephronophthisis (HP:0000090)2.48283345
29Genital tract atresia (HP:0001827)2.46657905
30Poor suck (HP:0002033)2.45145851
31Hepatocellular necrosis (HP:0001404)2.45082519
32Epileptic encephalopathy (HP:0200134)2.44164622
33Intestinal atresia (HP:0011100)2.43324627
34Hemiparesis (HP:0001269)2.36864885
35Vaginal atresia (HP:0000148)2.36703555
36Drooling (HP:0002307)2.36211230
37Hypoglycemic coma (HP:0001325)2.35861181
38Renal cortical cysts (HP:0000803)2.35443893
39Lissencephaly (HP:0001339)2.31980221
40Atonic seizures (HP:0010819)2.30591880
41Dialeptic seizures (HP:0011146)2.29743738
42Polyphagia (HP:0002591)2.27894402
43Progressive cerebellar ataxia (HP:0002073)2.27686590
44Increased hepatocellular lipid droplets (HP:0006565)2.27222673
45Type II lissencephaly (HP:0007260)2.26975908
46Methylmalonic aciduria (HP:0012120)2.22710842
47EEG with generalized epileptiform discharges (HP:0011198)2.21792588
48Epileptiform EEG discharges (HP:0011182)2.20842215
49Hypsarrhythmia (HP:0002521)2.18977428
50Ketoacidosis (HP:0001993)2.14400364
51Lipid accumulation in hepatocytes (HP:0006561)2.13655607
52Muscular hypotonia of the trunk (HP:0008936)2.10707193
53Abnormality of the renal cortex (HP:0011035)2.08249224
54Excessive salivation (HP:0003781)2.08142533
55Cerebral edema (HP:0002181)2.07549708
563-Methylglutaconic aciduria (HP:0003535)2.01454821
57Generalized tonic-clonic seizures (HP:0002069)2.00341621
58Absence seizures (HP:0002121)1.98839489
59Abnormality of the renal medulla (HP:0100957)1.96148899
60Abnormality of vitamin B metabolism (HP:0004340)1.95477610
61Poor coordination (HP:0002370)1.93979565
62Pachygyria (HP:0001302)1.93871144
63Hyperinsulinemic hypoglycemia (HP:0000825)1.93564661
64Inability to walk (HP:0002540)1.92897015
65Absent speech (HP:0001344)1.92226108
66Degeneration of the lateral corticospinal tracts (HP:0002314)1.91432069
67Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.91432069
68Abnormal rod and cone electroretinograms (HP:0008323)1.86596330
69Hyperglycinemia (HP:0002154)1.85768769
70Neoplasm of the adrenal cortex (HP:0100641)1.85601948
71Optic disc pallor (HP:0000543)1.84946959
72Gaze-evoked nystagmus (HP:0000640)1.83457645
73Spastic tetraplegia (HP:0002510)1.81684093
74Renal Fanconi syndrome (HP:0001994)1.80839786
75Hypomagnesemia (HP:0002917)1.80718542
76Specific learning disability (HP:0001328)1.79722625
77Aplasia/Hypoplasia of the tongue (HP:0010295)1.78851167
78Sclerocornea (HP:0000647)1.78155300
79Progressive inability to walk (HP:0002505)1.75957269
80Postaxial hand polydactyly (HP:0001162)1.75561810
81Pendular nystagmus (HP:0012043)1.75445990
82Decreased activity of mitochondrial respiratory chain (HP:0008972)1.74353976
83Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.74353976
84Abnormality of the corticospinal tract (HP:0002492)1.73527683
85Action tremor (HP:0002345)1.73430359
86Respiratory failure (HP:0002878)1.71835719
87Generalized aminoaciduria (HP:0002909)1.69744853
88Congenital stationary night blindness (HP:0007642)1.69514683
89Aplasia/hypoplasia of the uterus (HP:0008684)1.69076834
90Abolished electroretinogram (ERG) (HP:0000550)1.65763819
91Furrowed tongue (HP:0000221)1.64503173
92Retinal dysplasia (HP:0007973)1.64170626
93Narrow forehead (HP:0000341)1.63956714
94Delayed gross motor development (HP:0002194)1.62666112
95Aplasia/Hypoplasia of the tibia (HP:0005772)1.61923247
96Severe muscular hypotonia (HP:0006829)1.60580839
97Hypoglycemic seizures (HP:0002173)1.60261954
98Ketosis (HP:0001946)1.60023893
99Anencephaly (HP:0002323)1.59993060
100Decreased testicular size (HP:0008734)1.59685844

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK34.19842301
2FRK3.79974304
3CASK3.53735241
4MARK13.09729842
5MAP4K22.67696489
6TRIM282.65776004
7MAP3K42.51501711
8MAPK132.32618540
9BCR2.14206323
10MAP2K72.03753870
11NTRK31.99383321
12EPHA41.84324541
13NEK11.56119963
14ADRBK21.55183218
15CSNK1G21.55181770
16BMPR1B1.53108777
17PNCK1.50698413
18DYRK21.47668305
19MAP3K121.45557868
20CSNK1G31.44974301
21ERBB31.43204958
22LIMK11.42790293
23PAK31.40359384
24PINK11.40288659
25PHKG21.37990856
26PHKG11.37990856
27CSNK1G11.34926306
28MINK11.34221701
29PLK21.31276784
30VRK21.28207014
31PRKCG1.26767633
32MKNK21.26633826
33FGFR21.25872365
34UHMK11.23400269
35DAPK21.22157624
36MUSK1.21848789
37TNIK1.20901218
38CCNB11.18410241
39CSNK1A1L1.12824408
40NTRK21.11843914
41GRK11.11596746
42PRKCE1.11415509
43INSRR1.09872334
44VRK11.09700061
45MST41.09601434
46ZAK1.07455063
47PLK31.03329645
48EIF2AK31.00627221
49NUAK11.00081637
50STK160.98586919
51SRPK10.96479616
52TSSK60.93875364
53OXSR10.88131497
54BCKDK0.87922349
55CAMK2A0.83442667
56BUB10.79637020
57DYRK30.79521180
58TESK10.79069422
59MAP2K40.75057881
60CAMK2B0.73302922
61CAMK2D0.68748126
62EPHA30.68581719
63RPS6KA40.61697011
64PRKCI0.60262579
65DYRK1A0.57896215
66EIF2AK10.57300550
67MKNK10.56921294
68PIK3CA0.56339686
69GRK50.55808055
70FER0.54938559
71CDK30.54624510
72CDK50.54607574
73STK390.53769793
74PRKCZ0.53001776
75NME10.50415743
76CSNK1A10.50198036
77SIK20.49460744
78PKN10.49364025
79PAK60.48282969
80STK38L0.47430997
81CAMK2G0.45854348
82DAPK10.44202410
83PLK10.43467994
84PRKACA0.41901863
85SIK30.40858134
86CSNK1E0.40689977
87CSNK1D0.40248129
88RPS6KA50.40123390
89WNK40.39807297
90PLK40.39522714
91TAOK10.39506945
92PRKACB0.39358865
93PRKG10.39068278
94CDK140.38652058
95ADRBK10.37840292
96STK110.37594668
97WEE10.37526135
98ACVR1B0.35921404
99TAOK30.34674370
100TAF10.32355809

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.49258625
2Protein export_Homo sapiens_hsa030603.41679918
3Nicotine addiction_Homo sapiens_hsa050332.79196085
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.76556967
5Parkinsons disease_Homo sapiens_hsa050122.76534295
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.64847229
7Butanoate metabolism_Homo sapiens_hsa006502.18066964
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.97233378
9Alzheimers disease_Homo sapiens_hsa050101.94938743
10GABAergic synapse_Homo sapiens_hsa047271.91825030
11Collecting duct acid secretion_Homo sapiens_hsa049661.83272365
12Huntingtons disease_Homo sapiens_hsa050161.81759968
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.80917686
14Phototransduction_Homo sapiens_hsa047441.79875148
15Synaptic vesicle cycle_Homo sapiens_hsa047211.79230523
16Proteasome_Homo sapiens_hsa030501.73765269
17Insulin secretion_Homo sapiens_hsa049111.67863644
18Cardiac muscle contraction_Homo sapiens_hsa042601.64750478
19Propanoate metabolism_Homo sapiens_hsa006401.62555327
20RNA polymerase_Homo sapiens_hsa030201.61305823
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.61119091
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.58585113
23Steroid biosynthesis_Homo sapiens_hsa001001.54838082
24Glutamatergic synapse_Homo sapiens_hsa047241.54394647
25Morphine addiction_Homo sapiens_hsa050321.53333033
26Folate biosynthesis_Homo sapiens_hsa007901.52908171
27Circadian entrainment_Homo sapiens_hsa047131.52850659
28Dopaminergic synapse_Homo sapiens_hsa047281.52559614
29Amphetamine addiction_Homo sapiens_hsa050311.44024950
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.42433923
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41090777
32Taste transduction_Homo sapiens_hsa047421.36142958
33Basal transcription factors_Homo sapiens_hsa030221.34929567
34Fatty acid elongation_Homo sapiens_hsa000621.32525887
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31025081
36Sulfur metabolism_Homo sapiens_hsa009201.29523111
37Cocaine addiction_Homo sapiens_hsa050301.18456453
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16984575
39Regulation of autophagy_Homo sapiens_hsa041401.09934722
40RNA degradation_Homo sapiens_hsa030181.08628136
41Vitamin B6 metabolism_Homo sapiens_hsa007501.05289453
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05087603
43Vibrio cholerae infection_Homo sapiens_hsa051101.04243762
44Tryptophan metabolism_Homo sapiens_hsa003801.00562391
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98462813
46Serotonergic synapse_Homo sapiens_hsa047260.98356296
47Fanconi anemia pathway_Homo sapiens_hsa034600.94948423
48Long-term depression_Homo sapiens_hsa047300.92848030
49Peroxisome_Homo sapiens_hsa041460.92740845
50Oocyte meiosis_Homo sapiens_hsa041140.90300820
51Ether lipid metabolism_Homo sapiens_hsa005650.87820043
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87638797
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76969275
54Selenocompound metabolism_Homo sapiens_hsa004500.76853455
55Salivary secretion_Homo sapiens_hsa049700.75676836
56Non-homologous end-joining_Homo sapiens_hsa034500.73772492
57Renin secretion_Homo sapiens_hsa049240.72552155
58Olfactory transduction_Homo sapiens_hsa047400.71936835
59Linoleic acid metabolism_Homo sapiens_hsa005910.69756657
60Metabolic pathways_Homo sapiens_hsa011000.68413380
61Purine metabolism_Homo sapiens_hsa002300.68211794
62Homologous recombination_Homo sapiens_hsa034400.67932764
63Circadian rhythm_Homo sapiens_hsa047100.67654265
64beta-Alanine metabolism_Homo sapiens_hsa004100.64802958
65Nitrogen metabolism_Homo sapiens_hsa009100.60746833
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60660210
67Cholinergic synapse_Homo sapiens_hsa047250.59055109
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58740333
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58409755
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57053688
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56123885
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55339323
73Pyruvate metabolism_Homo sapiens_hsa006200.55227672
74Caffeine metabolism_Homo sapiens_hsa002320.54840104
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52955768
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.51038899
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49899483
78Fatty acid metabolism_Homo sapiens_hsa012120.49863940
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.48291230
80One carbon pool by folate_Homo sapiens_hsa006700.47389406
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46089280
82RNA transport_Homo sapiens_hsa030130.44158521
83Gastric acid secretion_Homo sapiens_hsa049710.44152232
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43152494
85Axon guidance_Homo sapiens_hsa043600.42891557
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42566272
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41736406
88Pyrimidine metabolism_Homo sapiens_hsa002400.40530423
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36059215
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34214725
91Calcium signaling pathway_Homo sapiens_hsa040200.33685322
92N-Glycan biosynthesis_Homo sapiens_hsa005100.33257283
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32419913
94Retinol metabolism_Homo sapiens_hsa008300.32313931
95cAMP signaling pathway_Homo sapiens_hsa040240.32268218
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.32246120
97Mineral absorption_Homo sapiens_hsa049780.31206186
98Chemical carcinogenesis_Homo sapiens_hsa052040.31196554
99Spliceosome_Homo sapiens_hsa030400.29734492
100Glucagon signaling pathway_Homo sapiens_hsa049220.29349948

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