C3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.24998575
2L-phenylalanine catabolic process (GO:0006559)7.24998575
3L-phenylalanine metabolic process (GO:0006558)6.90587074
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.90587074
5aromatic amino acid family catabolic process (GO:0009074)6.39770732
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.25513534
7negative regulation of fibrinolysis (GO:0051918)5.68044228
8indole-containing compound catabolic process (GO:0042436)5.66584730
9indolalkylamine catabolic process (GO:0046218)5.66584730
10tryptophan catabolic process (GO:0006569)5.66584730
11kynurenine metabolic process (GO:0070189)5.59908437
12urea cycle (GO:0000050)5.59764103
13urea metabolic process (GO:0019627)5.59764103
14bile acid biosynthetic process (GO:0006699)5.53937701
15alpha-linolenic acid metabolic process (GO:0036109)5.50222130
16protein carboxylation (GO:0018214)5.45084916
17peptidyl-glutamic acid carboxylation (GO:0017187)5.45084916
18high-density lipoprotein particle remodeling (GO:0034375)5.40855421
19regulation of fibrinolysis (GO:0051917)5.38784495
20glyoxylate metabolic process (GO:0046487)5.37203413
21tryptophan metabolic process (GO:0006568)5.34918681
22regulation of plasminogen activation (GO:0010755)5.33399256
23* regulation of protein activation cascade (GO:2000257)5.33187357
24sulfur amino acid catabolic process (GO:0000098)5.33122527
25epoxygenase P450 pathway (GO:0019373)5.25595589
26cysteine metabolic process (GO:0006534)5.24471144
27* complement activation, alternative pathway (GO:0006957)5.20212791
28exogenous drug catabolic process (GO:0042738)5.14048065
29nitrogen cycle metabolic process (GO:0071941)5.13022639
30* regulation of complement activation (GO:0030449)4.92612334
31intestinal cholesterol absorption (GO:0030299)4.91807283
32serine family amino acid catabolic process (GO:0009071)4.90902422
33bile acid metabolic process (GO:0008206)4.84837515
34homocysteine metabolic process (GO:0050667)4.81977815
35reverse cholesterol transport (GO:0043691)4.81123958
36omega-hydroxylase P450 pathway (GO:0097267)4.80695413
37* regulation of apoptotic cell clearance (GO:2000425)4.77813485
38plasma lipoprotein particle remodeling (GO:0034369)4.72564142
39protein-lipid complex remodeling (GO:0034368)4.72564142
40macromolecular complex remodeling (GO:0034367)4.72564142
41regulation of cholesterol esterification (GO:0010872)4.71210333
42regulation of triglyceride catabolic process (GO:0010896)4.70681170
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.69479770
44tyrosine metabolic process (GO:0006570)4.63886845
45* regulation of humoral immune response (GO:0002920)4.62241044
46aromatic amino acid family metabolic process (GO:0009072)4.61047569
47plasma lipoprotein particle clearance (GO:0034381)4.58816580
48amino-acid betaine metabolic process (GO:0006577)4.55471614
49triglyceride homeostasis (GO:0070328)4.54365051
50acylglycerol homeostasis (GO:0055090)4.54365051
51negative regulation of blood coagulation (GO:0030195)4.53660718
52negative regulation of hemostasis (GO:1900047)4.53660718
53negative regulation of complement activation (GO:0045916)4.50265004
54phospholipid efflux (GO:0033700)4.45765887
55alpha-amino acid catabolic process (GO:1901606)4.44020143
56lysine metabolic process (GO:0006553)4.41082429
57lysine catabolic process (GO:0006554)4.41082429
58negative regulation of cholesterol transport (GO:0032375)4.35685911
59negative regulation of sterol transport (GO:0032372)4.35685911
60bile acid and bile salt transport (GO:0015721)4.33493209
61positive regulation of hemostasis (GO:1900048)4.24676615
62positive regulation of blood coagulation (GO:0030194)4.24676615
63protein-lipid complex subunit organization (GO:0071825)4.24116076
64cellular ketone body metabolic process (GO:0046950)4.21099039
65ethanol metabolic process (GO:0006067)4.20286026
66negative regulation of coagulation (GO:0050819)4.19778903
67imidazole-containing compound metabolic process (GO:0052803)4.19433058
68cholesterol efflux (GO:0033344)4.18062471
69fibrinolysis (GO:0042730)4.11212456
70glycine metabolic process (GO:0006544)4.09526069
71cellular amino acid catabolic process (GO:0009063)4.09478157
72cellular glucuronidation (GO:0052695)4.07780435
73low-density lipoprotein particle remodeling (GO:0034374)4.05431601
74negative regulation of wound healing (GO:0061045)4.05372197
75glutamate metabolic process (GO:0006536)4.04474607
76indolalkylamine metabolic process (GO:0006586)3.99032575
77plasma lipoprotein particle assembly (GO:0034377)3.97858029
78opsonization (GO:0008228)3.97685461
79ethanol oxidation (GO:0006069)3.95197439
80coenzyme catabolic process (GO:0009109)3.92397551
81positive regulation of coagulation (GO:0050820)3.91904471
82benzene-containing compound metabolic process (GO:0042537)3.90686242
83negative regulation of protein activation cascade (GO:2000258)3.90343726
84cellular modified amino acid catabolic process (GO:0042219)3.90226548
85amine catabolic process (GO:0009310)3.89934817
86cellular biogenic amine catabolic process (GO:0042402)3.89934817
87serine family amino acid metabolic process (GO:0009069)3.89294614
88arginine metabolic process (GO:0006525)3.86595166
89phospholipid homeostasis (GO:0055091)3.86542672
90dicarboxylic acid biosynthetic process (GO:0043650)3.82631689
91blood coagulation, intrinsic pathway (GO:0007597)3.79867394
92drug catabolic process (GO:0042737)3.79320494
93positive regulation of lipid catabolic process (GO:0050996)3.78057631
94positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.77737450
95positive regulation of fatty acid biosynthetic process (GO:0045723)3.76353904
96acute-phase response (GO:0006953)3.75239596
97aldehyde catabolic process (GO:0046185)3.73123388
98cholesterol homeostasis (GO:0042632)3.72270415
99lipoprotein metabolic process (GO:0042157)3.72214463
100* protein activation cascade (GO:0072376)3.71237329
101serine family amino acid biosynthetic process (GO:0009070)3.70209405
102* complement activation (GO:0006956)3.68348456
103negative regulation of lipase activity (GO:0060192)3.67869328
104regulation of cholesterol homeostasis (GO:2000188)3.67610821
105positive regulation of lipoprotein lipase activity (GO:0051006)3.67153714
106positive regulation of triglyceride lipase activity (GO:0061365)3.67153714
107sterol homeostasis (GO:0055092)3.66524755
108drug metabolic process (GO:0017144)3.66150599
109very-low-density lipoprotein particle assembly (GO:0034379)3.64367270
110plasma lipoprotein particle organization (GO:0071827)3.64065665
111ketone body metabolic process (GO:1902224)3.63028872
112glucuronate metabolic process (GO:0019585)3.60889597
113uronic acid metabolic process (GO:0006063)3.60889597
114organic acid catabolic process (GO:0016054)3.60831238
115carboxylic acid catabolic process (GO:0046395)3.60831238
116protein-lipid complex assembly (GO:0065005)3.60116657
117regulation of bile acid biosynthetic process (GO:0070857)3.59826616
118acute inflammatory response (GO:0002526)3.58637338
119negative regulation of humoral immune response (GO:0002921)3.58240198
120short-chain fatty acid metabolic process (GO:0046459)3.54466623
121* complement activation, classical pathway (GO:0006958)3.53662639
122cytolysis (GO:0019835)3.53565641
123cofactor catabolic process (GO:0051187)3.53398478
124positive regulation of fatty acid beta-oxidation (GO:0032000)3.52897910
125positive regulation of extracellular matrix organization (GO:1903055)3.49407352
126sterol transport (GO:0015918)3.38663284
127cholesterol transport (GO:0030301)3.38663284
128regulation of cholesterol biosynthetic process (GO:0045540)3.32801673
129* regulation of acute inflammatory response (GO:0002673)3.29950557
130negative regulation of lipid transport (GO:0032369)3.25542154
131response to mercury ion (GO:0046689)3.21590404
132positive regulation of steroid metabolic process (GO:0045940)3.18688208
133regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.18018017
134sodium-independent organic anion transport (GO:0043252)3.17303652
135intestinal absorption (GO:0050892)3.15964592
136proline metabolic process (GO:0006560)3.03988254
137oxidative demethylation (GO:0070989)3.00978287

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.04909897
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.88706280
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.51106419
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.33070335
5* PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.21723444
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.04776030
7* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.83701708
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.00262045
9* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.68815030
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.27050778
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14940826
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.00434600
13* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.3409175
14CLOCK_20551151_ChIP-Seq_293T_Human1.99223134
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.84543452
16* FOXA2_19822575_ChIP-Seq_HepG2_Human1.62390590
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54338076
18GATA1_22025678_ChIP-Seq_K562_Human1.53260655
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48258175
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46449349
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39351688
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35425037
23* HNF4A_19822575_ChIP-Seq_HepG2_Human1.35072743
24HTT_18923047_ChIP-ChIP_STHdh_Human1.33300131
25NFIB_24661679_ChIP-Seq_LUNG_Mouse1.31457408
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.25404579
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.22566913
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.22003262
29CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17026830
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16332536
31RXRA_24833708_ChIP-Seq_LIVER_Mouse1.12146424
32TCF4_18268006_ChIP-ChIP_LS174T_Human1.11589784
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07829000
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.04482305
35Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02418582
36SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02072465
37ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01270506
38CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00202661
39ESR2_21235772_ChIP-Seq_MCF-7_Human0.99586107
40BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97541129
41CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95735564
42* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95534217
43ERG_21242973_ChIP-ChIP_JURKAT_Human0.93027210
44SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91801101
45DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91485648
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90589001
47P63_26484246_Chip-Seq_KERATINOCYTES_Human0.89297215
48ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88234531
49GATA4_25053715_ChIP-Seq_YYC3_Human0.88180296
50DROSHA_22980978_ChIP-Seq_HELA_Human0.84381316
51SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83668528
52SMC4_20622854_ChIP-Seq_HELA_Human0.83429442
53CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83163785
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.82875181
55RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.81394407
56ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80696134
57ZNF263_19887448_ChIP-Seq_K562_Human0.80274059
58SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79187709
59NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78657342
60NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78657342
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.78378590
62EP300_21415370_ChIP-Seq_HL-1_Mouse0.77886539
63AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76272001
64SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75400364
65KDM2B_26808549_Chip-Seq_K562_Human0.75344054
66ESR1_21235772_ChIP-Seq_MCF-7_Human0.75151567
67* ESR1_15608294_ChIP-ChIP_MCF-7_Human0.74533803
68AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.73177056
69ELK3_25401928_ChIP-Seq_HUVEC_Human0.72948002
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.71462476
71SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.70087815
72STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.69982743
73LXR_22292898_ChIP-Seq_THP-1_Human0.69517565
74RARA_24833708_ChIP-Seq_LIVER_Mouse0.68605013
75CJUN_26792858_Chip-Seq_BT549_Human0.66036924
76SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.65512223
77TP53_16413492_ChIP-PET_HCT116_Human0.65071353
78PPAR_26484153_Chip-Seq_NCI-H1993_Human0.65024456
79ESR1_20079471_ChIP-ChIP_T-47D_Human0.64510410
80KDM2B_26808549_Chip-Seq_SUP-B15_Human0.64432779
81ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.64183422
82FOXO3_23340844_ChIP-Seq_DLD1_Human0.63774162
83SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.63311083
84GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.63196498
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.62377309
86RUNX1_27514584_Chip-Seq_MCF-7_Human0.62364773
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.61108371
88GATA1_19941826_ChIP-Seq_K562_Human0.60719344
89* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.60473646
90BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59900634
91KAP1_22055183_ChIP-Seq_ESCs_Mouse0.59178228
92RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59066030
93EGR1_19032775_ChIP-ChIP_M12_Human0.58617524
94TRIM28_21343339_ChIP-Seq_HEK293_Human0.58474739
95RARB_24833708_ChIP-Seq_LIVER_Mouse0.58435852
96PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.57737234
97NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57459306
98CDX2_20551321_ChIP-Seq_CACO-2_Human0.56771865
99FOXA1_25552417_ChIP-Seq_VCAP_Human0.56370813
100* CEBPB_22108803_ChIP-Seq_LS180_Human0.55173218
101FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.55000426
102GATA2_19941826_ChIP-Seq_K562_Human0.54803798
103FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.54690474
104SOX2_20726797_ChIP-Seq_SW620_Human0.53992454
105PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.53398472
106STAT3_1855785_ChIP-Seq_MESCs_Mouse0.53038954
107NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.50117793
108MYC_19915707_ChIP-ChIP_AK7_Human0.49918205
109PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.49850109
110NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.49670614
111GATA2_21666600_ChIP-Seq_HMVEC_Human0.47880596
112GATA6_25053715_ChIP-Seq_YYC3_Human0.47698573
113GATA1_19941827_ChIP-Seq_MEL_Mouse0.46602389
114SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.45849032
115AR_20517297_ChIP-Seq_VCAP_Human0.44467052
116ESET_19884257_ChIP-Seq_ESCs_Mouse0.44010467
117IRF8_27001747_Chip-Seq_BMDM_Mouse0.43969120
118FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.43890617
119CBP_21632823_ChIP-Seq_H3396_Human0.43563166
120* STAT1_17558387_ChIP-Seq_HELA_Human0.43193258
121P53_21459846_ChIP-Seq_SAOS-2_Human0.42881754
122GATA3_24758297_ChIP-Seq_MCF-7_Human0.42829313
123RACK7_27058665_Chip-Seq_MCF-7_Human0.42187110
124BCAT_22108803_ChIP-Seq_LS180_Human0.42067476
125SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41689400
126* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.41581947
127ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.41325581
128TBX20_22080862_ChIP-Seq_HEART_Mouse0.41311651
129TBX20_22328084_ChIP-Seq_HEART_Mouse0.41311651
130NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.39435892
131* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.38459938
132FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.38200614

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.89089394
2MP0005360_urolithiasis7.24664036
3MP0005085_abnormal_gallbladder_physiolo6.08402209
4MP0005365_abnormal_bile_salt5.88308982
5MP0008875_abnormal_xenobiotic_pharmacok5.10851281
6MP0003806_abnormal_nucleotide_metabolis3.87217708
7MP0003252_abnormal_bile_duct3.75270950
8MP0010329_abnormal_lipoprotein_level3.62181112
9MP0009840_abnormal_foam_cell3.26877055
10MP0005083_abnormal_biliary_tract3.15891458
11MP0003195_calcinosis2.67764957
12MP0005332_abnormal_amino_acid2.66137106
13MP0003191_abnormal_cellular_cholesterol2.64939348
14MP0001666_abnormal_nutrient_absorption2.48263313
15MP0000609_abnormal_liver_physiology2.20887446
16MP0004019_abnormal_vitamin_homeostasis2.13622862
17MP0002118_abnormal_lipid_homeostasis2.11899903
18MP0002138_abnormal_hepatobiliary_system2.01483155
19MP0005319_abnormal_enzyme/_coenzyme1.81972097
20MP0003868_abnormal_feces_composition1.65452894
21MP0002254_reproductive_system_inflammat1.60534903
22MP0005584_abnormal_enzyme/coenzyme_acti1.56865060
23MP0001764_abnormal_homeostasis1.54862746
24MP0001915_intracranial_hemorrhage1.52809639
25MP0003705_abnormal_hypodermis_morpholog1.51329183
26MP0003122_maternal_imprinting1.45790799
27MP0000566_synostosis1.44975907
28MP0000604_amyloidosis1.36130217
29MP0009697_abnormal_copulation1.32872292
30MP0003011_delayed_dark_adaptation1.32565657
31MP0005451_abnormal_body_composition1.32090667
32MP0004272_abnormal_basement_membrane1.31914886
33MP0009643_abnormal_urine_homeostasis1.29001736
34MP0003656_abnormal_erythrocyte_physiolo1.28388032
35MP0003186_abnormal_redox_activity1.26636658
36MP0000598_abnormal_liver_morphology1.20348177
37MP0009764_decreased_sensitivity_to1.19360708
38MP0005670_abnormal_white_adipose1.14540865
39MP0003172_abnormal_lysosome_physiology1.14335015
40MP0002132_abnormal_respiratory_system1.13184837
41MP0010368_abnormal_lymphatic_system1.12532568
42MP0002089_abnormal_postnatal_growth/wei1.11618653
43MP0005409_darkened_coat_color1.09597020
44MP0005647_abnormal_sex_gland1.09294812
45* MP0009763_increased_sensitivity_to1.06256136
46MP0003879_abnormal_hair_cell1.03339099
47MP0003566_abnormal_cell_adhesion1.03300059
48MP0008469_abnormal_protein_level0.97729758
49MP0005636_abnormal_mineral_homeostasis0.94700435
50MP0004130_abnormal_muscle_cell0.94612533
51* MP0009642_abnormal_blood_homeostasis0.87755389
52MP0009780_abnormal_chondrocyte_physiolo0.85932734
53MP0002933_joint_inflammation0.82968153
54MP0003329_amyloid_beta_deposits0.80687024
55MP0005376_homeostasis/metabolism_phenot0.79114504
56MP0005334_abnormal_fat_pad0.78753929
57MP0002078_abnormal_glucose_homeostasis0.78269283
58MP0005257_abnormal_intraocular_pressure0.78139251
59MP0003690_abnormal_glial_cell0.77493962
60MP0000920_abnormal_myelination0.76594802
61MP0005408_hypopigmentation0.76461130
62MP0002876_abnormal_thyroid_physiology0.76228891
63MP0009765_abnormal_xenobiotic_induced0.75890306
64MP0003724_increased_susceptibility_to0.75305761
65MP0003950_abnormal_plasma_membrane0.74122111
66* MP0002971_abnormal_brown_adipose0.70619795
67MP0005220_abnormal_exocrine_pancreas0.69784480
68MP0006036_abnormal_mitochondrial_physio0.68696357
69MP0001756_abnormal_urination0.68189587
70MP0008438_abnormal_cutaneous_collagen0.67697002
71MP0005535_abnormal_body_temperature0.65943786
72MP0005084_abnormal_gallbladder_morpholo0.64896178
73MP0009053_abnormal_anal_canal0.63782119
74MP0000639_abnormal_adrenal_gland0.63289198
75MP0002998_abnormal_bone_remodeling0.62945492
76MP0005666_abnormal_adipose_tissue0.61556117
77MP0002909_abnormal_adrenal_gland0.59256516
78MP0006054_spinal_hemorrhage0.58138909
79MP0005375_adipose_tissue_phenotype0.57921322
80MP0003075_altered_response_to0.57348812
81MP0000003_abnormal_adipose_tissue0.56843963
82MP0000858_altered_metastatic_potential0.55932398
83* MP0005464_abnormal_platelet_physiology0.55880774
84MP0004782_abnormal_surfactant_physiolog0.55801384
85MP0002837_dystrophic_cardiac_calcinosis0.54792257
86MP0002136_abnormal_kidney_physiology0.54545913
87MP0008004_abnormal_stomach_pH0.54307863
88MP0005076_abnormal_cell_differentiation0.53838528
89MP0004883_abnormal_blood_vessel0.53438906
90MP0000767_abnormal_smooth_muscle0.52905091
91MP0003632_abnormal_nervous_system0.51981646
92MP0005395_other_phenotype0.51819947
93MP0005164_abnormal_response_to0.51303675
94MP0005266_abnormal_metabolism0.51065032
95* MP0005448_abnormal_energy_balance0.50792359
96MP0002896_abnormal_bone_mineralization0.50132344
97MP0005058_abnormal_lysosome_morphology0.49605364
98MP0003638_abnormal_response/metabolism_0.49282289
99MP0006082_CNS_inflammation0.48417182
100MP0001881_abnormal_mammary_gland0.48093256
101MP0002928_abnormal_bile_duct0.47773232
102MP0009115_abnormal_fat_cell0.47568603
103MP0005166_decreased_susceptibility_to0.46791766
104MP0009384_cardiac_valve_regurgitation0.46748741
105MP0002060_abnormal_skin_morphology0.46740153
106MP0002168_other_aberrant_phenotype0.46298070
107MP0002128_abnormal_blood_circulation0.46232609
108MP0005167_abnormal_blood-brain_barrier0.45988561
109MP0008873_increased_physiological_sensi0.45980773
110MP0008874_decreased_physiological_sensi0.45490254
111* MP0000249_abnormal_blood_vessel0.45404028
112MP0005377_hearing/vestibular/ear_phenot0.45091518
113MP0003878_abnormal_ear_physiology0.45091518
114MP0002282_abnormal_trachea_morphology0.44618481
115MP0002295_abnormal_pulmonary_circulatio0.43634353
116MP0005165_increased_susceptibility_to0.43368960
117* MP0003436_decreased_susceptibility_to0.43263787
118MP0001845_abnormal_inflammatory_respons0.41472641
119MP0005023_abnormal_wound_healing0.41263637
120MP0001243_abnormal_dermal_layer0.40369814
121MP0003953_abnormal_hormone_level0.40292475
122MP0005248_abnormal_Harderian_gland0.39426321
123MP0002796_impaired_skin_barrier0.37977471
124MP0003300_gastrointestinal_ulcer0.37900052
125MP0006035_abnormal_mitochondrial_morpho0.37862040
126MP0001853_heart_inflammation0.37804468
127MP0010234_abnormal_vibrissa_follicle0.36069005
128MP0004185_abnormal_adipocyte_glucose0.35649724
129MP0000230_abnormal_systemic_arterial0.35066152
130MP0009785_altered_susceptibility_to0.34086590
131MP0003453_abnormal_keratinocyte_physiol0.33558604
132MP0009672_abnormal_birth_weight0.32982902
133MP0005275_abnormal_skin_tensile0.32869672

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.57975983
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.00060879
3Intrahepatic cholestasis (HP:0001406)6.95854753
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.47473600
5Prolonged partial thromboplastin time (HP:0003645)6.41386096
6Xanthomatosis (HP:0000991)6.23741328
7Hypobetalipoproteinemia (HP:0003563)6.12694500
8Hyperlipoproteinemia (HP:0010980)5.54614924
9* Complement deficiency (HP:0004431)4.96404574
10Joint hemorrhage (HP:0005261)4.91629058
11Abnormality of the common coagulation pathway (HP:0010990)4.75170990
12Hypolipoproteinemia (HP:0010981)4.74395800
13Epidermoid cyst (HP:0200040)4.54251465
14Hyperammonemia (HP:0001987)4.50577275
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.41398481
16Hypoalphalipoproteinemia (HP:0003233)4.26791999
17Abnormality of glutamine family amino acid metabolism (HP:0010902)4.18970284
18Hyperglycinemia (HP:0002154)4.18277121
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.08802020
20Ketosis (HP:0001946)4.07329510
21Abnormality of methionine metabolism (HP:0010901)4.02756637
22Fat malabsorption (HP:0002630)3.91127362
23Abnormality of aspartate family amino acid metabolism (HP:0010899)3.89624804
24Hyperglycinuria (HP:0003108)3.85067412
25Abnormality of glycine metabolism (HP:0010895)3.81345729
26Abnormality of serine family amino acid metabolism (HP:0010894)3.81345729
27Hypoglycemic coma (HP:0001325)3.77717471
28Hypercholesterolemia (HP:0003124)3.77205482
29Abnormality of the intrinsic pathway (HP:0010989)3.71337391
30Conjugated hyperbilirubinemia (HP:0002908)3.64382875
31Abnormality of pyrimidine metabolism (HP:0004353)3.59342818
32* Abnormality of complement system (HP:0005339)3.54691407
33Spontaneous abortion (HP:0005268)3.40719377
34Myocardial infarction (HP:0001658)3.28649484
35Hyperbilirubinemia (HP:0002904)3.21899905
36Systemic lupus erythematosus (HP:0002725)3.20648243
37Abnormality of fatty-acid metabolism (HP:0004359)3.19814464
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.17211218
39Purpura (HP:0000979)3.15705540
40Abnormality of nucleobase metabolism (HP:0010932)3.02740174
41Skin nodule (HP:0200036)3.00939862
42Hepatocellular carcinoma (HP:0001402)2.93805403
43Ketoacidosis (HP:0001993)2.90912684
44Delayed CNS myelination (HP:0002188)2.87308140
45Steatorrhea (HP:0002570)2.83494440
46Abnormality of serum amino acid levels (HP:0003112)2.82978994
47Abnormality of purine metabolism (HP:0004352)2.74438851
48Hypochromic microcytic anemia (HP:0004840)2.68749193
49Amyloidosis (HP:0011034)2.63741234
50Vascular calcification (HP:0004934)2.63131501
51Gingival bleeding (HP:0000225)2.59159603
52Metabolic acidosis (HP:0001942)2.58368685
53Mitral stenosis (HP:0001718)2.53667019
54Acanthocytosis (HP:0001927)2.53207457
55Esophageal varix (HP:0002040)2.53121275
56Spastic diplegia (HP:0001264)2.51581671
57Recurrent gram-negative bacterial infections (HP:0005420)2.48642327
58Dicarboxylic aciduria (HP:0003215)2.42443807
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.42443807
60Lethargy (HP:0001254)2.40770999
61Cardiovascular calcification (HP:0011915)2.40287015
62Abnormal gallbladder morphology (HP:0012437)2.39876468
63Hypoglycemic seizures (HP:0002173)2.35662422
64Cholelithiasis (HP:0001081)2.35190534
65Gout (HP:0001997)2.34267274
66Menorrhagia (HP:0000132)2.34236851
67Malnutrition (HP:0004395)2.31151883
68Hemorrhage of the eye (HP:0011885)2.26806610
69Thrombophlebitis (HP:0004418)2.25860877
70Irritability (HP:0000737)2.23068792
71Abnormal gallbladder physiology (HP:0012438)2.22416767
72Cholecystitis (HP:0001082)2.22416767
73Abnormality of carpal bone ossification (HP:0006257)2.21955729
74Protrusio acetabuli (HP:0003179)2.21929462
75Neonatal onset (HP:0003623)2.21105830
76Cerebral aneurysm (HP:0004944)2.19192117
77Pancreatitis (HP:0001733)2.18889817
78Cerebral edema (HP:0002181)2.14934601
79Abnormality of proline metabolism (HP:0010907)2.05856787
80Hydroxyprolinuria (HP:0003080)2.05856787
81Sensorimotor neuropathy (HP:0007141)2.04343439
82Late onset (HP:0003584)2.02510590
83Flat acetabular roof (HP:0003180)2.01056392
84Abnormality of iron homeostasis (HP:0011031)2.00992168
85Vomiting (HP:0002013)1.99228922
86Abnormal cartilage morphology (HP:0002763)1.98728284
87Generalized aminoaciduria (HP:0002909)1.98372366
88* Glomerulonephritis (HP:0000099)1.97247748
89Abnormality of transition element cation homeostasis (HP:0011030)1.95862449
90Arthropathy (HP:0003040)1.95007436
91Poikilocytosis (HP:0004447)1.93333791
92Osteomalacia (HP:0002749)1.92647821
93Abnormality of the Achilles tendon (HP:0005109)1.92353443
94Abnormality of the gallbladder (HP:0005264)1.92062820
95Enlarged kidneys (HP:0000105)1.92002757
96Opisthotonus (HP:0002179)1.91184213
97Urinary glycosaminoglycan excretion (HP:0003541)1.90932676
98Mucopolysacchariduria (HP:0008155)1.90932676
99Brushfield spots (HP:0001088)1.90677265
100Facial shape deformation (HP:0011334)1.87146336
101Potter facies (HP:0002009)1.87146336
102Hypertriglyceridemia (HP:0002155)1.86936598
103Hyperinsulinemic hypoglycemia (HP:0000825)1.85424825
104Epistaxis (HP:0000421)1.80951601
105Stroke (HP:0001297)1.80857927
106Pulmonary embolism (HP:0002204)1.80540377
107Abnormal enzyme/coenzyme activity (HP:0012379)1.79210386
108Alkalosis (HP:0001948)1.77864016
109Rickets (HP:0002748)1.77367410
110Abnormal tarsal ossification (HP:0008369)1.76751207
111Elevated hepatic transaminases (HP:0002910)1.73380529
112Abnormality of polysaccharide metabolism (HP:0011012)1.72880369
113Abnormality of glycosaminoglycan metabolism (HP:0004371)1.72880369
114Abnormality of mucopolysaccharide metabolism (HP:0011020)1.72880369
115Arterial tortuosity (HP:0005116)1.71830110
116* Nephritis (HP:0000123)1.70954968
117Hyperglycemia (HP:0003074)1.67704862
118Abnormal platelet function (HP:0011869)1.66909942
119Impaired platelet aggregation (HP:0003540)1.66909942
120Hypophosphatemic rickets (HP:0004912)1.66658192
121Peritonitis (HP:0002586)1.66363100
122Abnormal ossification of hand bones (HP:0005921)1.65265229
123Increased serum ferritin (HP:0003281)1.64338984
124Abnormal delivery (HP:0001787)1.63125522
125Back pain (HP:0003418)1.61696101
126Abnormal hand bone ossification (HP:0010660)1.60879354
127Bifid scrotum (HP:0000048)1.60044793
128Vertebral compression fractures (HP:0002953)1.59829928
129Joint swelling (HP:0001386)1.59269904
130Vascular tortuosity (HP:0004948)1.59193549
131Retinal atrophy (HP:0001105)1.59023337
132Neurofibrillary tangles (HP:0002185)1.58318050
133Small epiphyses (HP:0010585)1.57820427
134Polycythemia (HP:0001901)1.54987368
135Asymmetry of the thorax (HP:0001555)1.52543053
136Glomerulosclerosis (HP:0000096)1.51267207
137Coxa vara (HP:0002812)1.47614133
138Elevated alkaline phosphatase (HP:0003155)1.47077728
139Abnormality of the lumbar spine (HP:0100712)1.45672299
140Gangrene (HP:0100758)1.44205306

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.07111386
2ERN14.66281115
3FGFR44.52914948
4SIK14.42615431
5TAOK32.93156881
6TRIB32.62173743
7INSRR2.62016589
8PKN22.47481942
9MST1R2.30949083
10ERBB42.14187845
11TYK22.00821896
12MAP2K41.81883056
13PIK3CG1.78791505
14FLT31.77842761
15DDR21.70254221
16PTK61.69947501
17LATS11.64155959
18PIK3CA1.56594704
19MAPK111.56263394
20CDC42BPA1.56114518
21EPHB11.55762385
22CDK121.49421199
23FGFR21.47539762
24FRK1.42950529
25DAPK21.40873192
26TGFBR21.40376998
27NEK91.39173601
28JAK11.36468684
29AKT31.31338994
30KDR1.30792361
31TBK11.29879859
32CAMK1D1.29056943
33TYRO31.27890459
34ABL21.27435194
35JAK21.26959246
36EPHA21.26155353
37LMTK21.25558726
38EEF2K1.23429163
39MAP3K21.21178052
40RIPK11.20207718
41WNK41.19954943
42EPHA31.19030076
43PRKAA21.12739616
44PDK21.12691628
45WNK11.12324671
46MAP2K31.11605917
47MAP3K141.08357657
48MAP3K71.08289490
49TIE11.01071135
50MET0.99972747
51LATS20.96686037
52CSK0.96487516
53FGFR30.96384970
54MAP3K100.94311920
55PDGFRB0.93051545
56MAPK40.88922590
57MAP3K30.86831053
58GRK60.84274693
59ERBB20.83761032
60SMG10.82765917
61MAPKAPK30.81279326
62CDK60.80290796
63PRKCZ0.79711517
64IKBKE0.79595893
65NTRK10.77573798
66IRAK30.75766809
67PTK20.73810666
68SGK2230.73331195
69SGK4940.73331195
70GSK3A0.72349520
71CAMK1G0.70837225
72MARK20.69676116
73MAPK120.68615285
74PRKACG0.67006889
75MYLK0.66297165
76NLK0.63254223
77NTRK30.61826868
78PDGFRA0.60927889
79PINK10.59111211
80PRKAA10.58913807
81CSF1R0.57438000
82MAP3K110.57140126
83SGK30.56982894
84DYRK1B0.54299144
85PDPK10.54037007
86STK38L0.53279349
87RET0.52924027
88MAPK150.51480046
89MAP2K10.50493073
90CAMK2G0.50295099
91SGK10.49365630
92KSR20.49199584
93BMX0.47777758
94SRC0.47758600
95FGR0.46901752
96IGF1R0.46431641
97MAP3K130.43830356
98MTOR0.43232175
99TTN0.42656601
100KIT0.42557945
101JAK30.42227134
102MAP2K60.41782771
103PRPF4B0.41566265
104MAPK70.41428436
105PRKG10.40249982
106MELK0.39784301
107IRAK10.39057023
108NEK60.38887593
109STK380.38751002
110EGFR0.38414917
111PRKCQ0.36441249
112MAP3K10.36157240
113EPHB20.36018224
114FER0.35847253
115TRPM70.35549817
116ZAP700.35196021
117MOS0.35193284
118MAPK30.34658707
119PAK20.34442192
120SIK20.33582923
121MAP3K60.33244339
122MAP3K50.31295799
123GRK10.31138840
124PDK10.30705331
125ABL10.30353828
126ICK0.29717070
127MAPKAPK20.29140835
128HIPK20.28838546
129BLK0.28772409
130PRKD10.28706345
131PAK40.28558716
132CDK40.28445524
133SGK20.27023074
134CSNK1G10.26716627
135FGFR10.26714157
136STK30.26702774
137DAPK30.25475914
138PDK30.24112524
139PDK40.24112524
140CHUK0.23357838
141PAK30.21946802

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.27810378
2Nitrogen metabolism_Homo sapiens_hsa009103.94639590
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.35897104
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33934676
5Arginine biosynthesis_Homo sapiens_hsa002203.11053671
6* Complement and coagulation cascades_Homo sapiens_hsa046102.90358705
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.62808429
8Tryptophan metabolism_Homo sapiens_hsa003802.59661947
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.54759781
10Fatty acid degradation_Homo sapiens_hsa000712.49851816
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.44907562
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39833749
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23765943
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11366673
15Butanoate metabolism_Homo sapiens_hsa006502.04751857
16Peroxisome_Homo sapiens_hsa041461.98713196
17Propanoate metabolism_Homo sapiens_hsa006401.96678330
18* Staphylococcus aureus infection_Homo sapiens_hsa051501.96412783
19PPAR signaling pathway_Homo sapiens_hsa033201.95605459
20Histidine metabolism_Homo sapiens_hsa003401.93488542
21Chemical carcinogenesis_Homo sapiens_hsa052041.93193898
22Caffeine metabolism_Homo sapiens_hsa002321.90323218
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.89836615
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.89055183
25Fatty acid metabolism_Homo sapiens_hsa012121.83782598
26beta-Alanine metabolism_Homo sapiens_hsa004101.76015644
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.71389056
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.69765150
29Retinol metabolism_Homo sapiens_hsa008301.63548879
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62119434
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57229642
32Phenylalanine metabolism_Homo sapiens_hsa003601.56634144
33Selenocompound metabolism_Homo sapiens_hsa004501.51013002
34Bile secretion_Homo sapiens_hsa049761.50530024
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47406665
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39109066
37Tyrosine metabolism_Homo sapiens_hsa003501.38914202
38Pyruvate metabolism_Homo sapiens_hsa006201.32139322
39Starch and sucrose metabolism_Homo sapiens_hsa005001.28028583
40Sulfur metabolism_Homo sapiens_hsa009201.27979355
41ABC transporters_Homo sapiens_hsa020101.27202822
42Other glycan degradation_Homo sapiens_hsa005111.26897481
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.23174795
44Fat digestion and absorption_Homo sapiens_hsa049751.21673961
45Fatty acid elongation_Homo sapiens_hsa000621.20096346
46Biosynthesis of amino acids_Homo sapiens_hsa012301.17948900
47Steroid biosynthesis_Homo sapiens_hsa001001.17931020
48Carbon metabolism_Homo sapiens_hsa012001.13111659
49Folate biosynthesis_Homo sapiens_hsa007901.07240541
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96743726
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.95142789
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92551334
53Arginine and proline metabolism_Homo sapiens_hsa003300.92201139
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88225531
55Vitamin digestion and absorption_Homo sapiens_hsa049770.87133132
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.86303025
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85102617
58Sulfur relay system_Homo sapiens_hsa041220.84439532
59Lysine degradation_Homo sapiens_hsa003100.82056328
60Vitamin B6 metabolism_Homo sapiens_hsa007500.78800080
61Glycerolipid metabolism_Homo sapiens_hsa005610.75318322
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67929540
63Fatty acid biosynthesis_Homo sapiens_hsa000610.65423236
64Glutathione metabolism_Homo sapiens_hsa004800.63691394
65One carbon pool by folate_Homo sapiens_hsa006700.62543633
66Pentose phosphate pathway_Homo sapiens_hsa000300.61578574
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52812518
68ECM-receptor interaction_Homo sapiens_hsa045120.44694285
69Metabolic pathways_Homo sapiens_hsa011000.40401230
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38043046
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.34767293
72Insulin resistance_Homo sapiens_hsa049310.32927442
73Mineral absorption_Homo sapiens_hsa049780.32533631
74Prion diseases_Homo sapiens_hsa050200.29337609
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24977453
76Galactose metabolism_Homo sapiens_hsa000520.24317190
77Linoleic acid metabolism_Homo sapiens_hsa005910.21537097
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20567835
79Fructose and mannose metabolism_Homo sapiens_hsa000510.20083053
80N-Glycan biosynthesis_Homo sapiens_hsa005100.15308347
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.14775484
82Sphingolipid metabolism_Homo sapiens_hsa006000.14212704
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11710283
84Glucagon signaling pathway_Homo sapiens_hsa049220.10143926
85AMPK signaling pathway_Homo sapiens_hsa041520.08145911
86* Systemic lupus erythematosus_Homo sapiens_hsa053220.07344766
87Protein digestion and absorption_Homo sapiens_hsa049740.07329494
88Circadian rhythm_Homo sapiens_hsa047100.07148098
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.03720427
90Focal adhesion_Homo sapiens_hsa045100.02179723
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.2046674
92Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2030265
93Bladder cancer_Homo sapiens_hsa05219-0.1981377
94* Pertussis_Homo sapiens_hsa05133-0.1926539
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1727546
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1618386
97Malaria_Homo sapiens_hsa05144-0.1527675
98Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1518539
99Lysosome_Homo sapiens_hsa04142-0.1402351
100Renin-angiotensin system_Homo sapiens_hsa04614-0.1371446
101Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1252356
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1184777
103Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1183265
104Hepatitis C_Homo sapiens_hsa05160-0.1014357
105Amoebiasis_Homo sapiens_hsa05146-0.0990990
106African trypanosomiasis_Homo sapiens_hsa05143-0.0975517
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0923699
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0863206
109Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0739957
110HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0518720
111Insulin signaling pathway_Homo sapiens_hsa04910-0.0467735
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933-0.0058831

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