C2ORF91

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1indolalkylamine metabolic process (GO:0006586)4.83867470
2indole-containing compound catabolic process (GO:0042436)4.74806571
3indolalkylamine catabolic process (GO:0046218)4.74806571
4tryptophan catabolic process (GO:0006569)4.74806571
5behavioral response to nicotine (GO:0035095)4.55597384
6kynurenine metabolic process (GO:0070189)4.54966148
7detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.44886831
8tryptophan metabolic process (GO:0006568)4.12504484
9signal peptide processing (GO:0006465)4.04884858
10detection of light stimulus involved in visual perception (GO:0050908)3.98935255
11detection of light stimulus involved in sensory perception (GO:0050962)3.98935255
12tachykinin receptor signaling pathway (GO:0007217)3.96749502
13fucose catabolic process (GO:0019317)3.87585239
14L-fucose metabolic process (GO:0042354)3.87585239
15L-fucose catabolic process (GO:0042355)3.87585239
16behavioral response to ethanol (GO:0048149)3.69993667
17photoreceptor cell maintenance (GO:0045494)3.67994649
18response to pheromone (GO:0019236)3.62095327
19neural tube formation (GO:0001841)3.58762984
20auditory receptor cell stereocilium organization (GO:0060088)3.58211792
21G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.58061401
22indole-containing compound metabolic process (GO:0042430)3.54510197
23cilium or flagellum-dependent cell motility (GO:0001539)3.47861246
24cellular ketone body metabolic process (GO:0046950)3.41810616
25negative regulation of cytosolic calcium ion concentration (GO:0051481)3.40072875
26reflex (GO:0060004)3.34615919
27centriole replication (GO:0007099)3.32585934
28amine catabolic process (GO:0009310)3.27934458
29cellular biogenic amine catabolic process (GO:0042402)3.27934458
30protein K11-linked deubiquitination (GO:0035871)3.21440231
31ketone body metabolic process (GO:1902224)3.20319199
32DNA double-strand break processing (GO:0000729)3.20118900
33retinal cone cell development (GO:0046549)3.18422540
34inner ear receptor stereocilium organization (GO:0060122)3.12072078
35regulation of hippo signaling (GO:0035330)3.11212191
36nonmotile primary cilium assembly (GO:0035058)3.08944103
37benzene-containing compound metabolic process (GO:0042537)3.04873259
38gamma-aminobutyric acid transport (GO:0015812)3.03984200
39serotonin metabolic process (GO:0042428)3.02864523
40axoneme assembly (GO:0035082)3.00889718
41dopamine transport (GO:0015872)2.96007801
42regulation of sarcomere organization (GO:0060297)2.95633689
43negative regulation of translation, ncRNA-mediated (GO:0040033)2.90759794
44regulation of translation, ncRNA-mediated (GO:0045974)2.90759794
45negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.90759794
46primary amino compound metabolic process (GO:1901160)2.84444301
47protein localization to cilium (GO:0061512)2.83101793
48aromatic amino acid family catabolic process (GO:0009074)2.82601671
49aromatic amino acid family metabolic process (GO:0009072)2.81832581
50epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.81134717
51detection of mechanical stimulus involved in sensory perception (GO:0050974)2.77495369
52reciprocal DNA recombination (GO:0035825)2.77366902
53reciprocal meiotic recombination (GO:0007131)2.77366902
54NAD biosynthetic process (GO:0009435)2.74504492
55oxidative demethylation (GO:0070989)2.73098685
56cilium morphogenesis (GO:0060271)2.72877024
57protein prenylation (GO:0018342)2.72699748
58prenylation (GO:0097354)2.72699748
59cilium organization (GO:0044782)2.72423630
60establishment of protein localization to Golgi (GO:0072600)2.72132809
61double-strand break repair via homologous recombination (GO:0000724)2.70242659
62recombinational repair (GO:0000725)2.70060781
63rhodopsin mediated signaling pathway (GO:0016056)2.69713562
64platelet dense granule organization (GO:0060155)2.69558538
65regulation of rhodopsin mediated signaling pathway (GO:0022400)2.67608340
66L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.66460923
67cilium assembly (GO:0042384)2.66304597
68neuronal action potential (GO:0019228)2.65465235
69photoreceptor cell development (GO:0042461)2.65256042
70mannosylation (GO:0097502)2.64763334
71righting reflex (GO:0060013)2.63945386
72piRNA metabolic process (GO:0034587)2.63724151
73protein polyglutamylation (GO:0018095)2.62705308
74sulfation (GO:0051923)2.62423376
75regulation of hexokinase activity (GO:1903299)2.61763178
76regulation of glucokinase activity (GO:0033131)2.61763178
77water-soluble vitamin biosynthetic process (GO:0042364)2.59496087
78replication fork processing (GO:0031297)2.57971309
79DNA deamination (GO:0045006)2.57658200
80adaptation of signaling pathway (GO:0023058)2.57012619
81transmission of nerve impulse (GO:0019226)2.56943892
82cornea development in camera-type eye (GO:0061303)2.56326373
83positive regulation of developmental pigmentation (GO:0048087)2.56288421
84monoubiquitinated protein deubiquitination (GO:0035520)2.55580130
85protein K63-linked deubiquitination (GO:0070536)2.55198966
86negative regulation of mast cell activation (GO:0033004)2.52838432
87epithelial cilium movement (GO:0003351)2.52002103
88proline transport (GO:0015824)2.51977953
89respiratory chain complex IV assembly (GO:0008535)2.50200202
90regulation of neurotransmitter uptake (GO:0051580)2.49998404
91interkinetic nuclear migration (GO:0022027)2.45929217
92cellular response to sterol (GO:0036315)2.45781196
93neuronal action potential propagation (GO:0019227)2.45539559
94cAMP catabolic process (GO:0006198)2.45333804
95cilium movement (GO:0003341)2.44354668
96regulation of action potential (GO:0098900)2.44238666
97regulation of pigment cell differentiation (GO:0050932)2.43643650
98regulation of cilium movement (GO:0003352)2.43193924
99preassembly of GPI anchor in ER membrane (GO:0016254)2.43127794
100thyroid hormone metabolic process (GO:0042403)2.41694661

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.44632150
2ZNF274_21170338_ChIP-Seq_K562_Hela3.28682609
3VDR_22108803_ChIP-Seq_LS180_Human3.25861859
4IGF1R_20145208_ChIP-Seq_DFB_Human3.02900725
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.96149090
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.80336582
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.67608303
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.67287098
9EZH2_22144423_ChIP-Seq_EOC_Human2.53233256
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.49976626
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.34471374
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.29303832
13TAF15_26573619_Chip-Seq_HEK293_Human2.24903884
14P300_19829295_ChIP-Seq_ESCs_Human2.17114937
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05316456
16ER_23166858_ChIP-Seq_MCF-7_Human2.04434363
17FUS_26573619_Chip-Seq_HEK293_Human2.03751905
18AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.03680627
19EWS_26573619_Chip-Seq_HEK293_Human1.97804198
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.93501071
21SALL1_21062744_ChIP-ChIP_HESCs_Human1.93104635
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87452532
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.85774539
24STAT3_23295773_ChIP-Seq_U87_Human1.85165385
25SMAD4_21799915_ChIP-Seq_A2780_Human1.81565052
26BCAT_22108803_ChIP-Seq_LS180_Human1.76629300
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73595888
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.72307286
29TCF4_23295773_ChIP-Seq_U87_Human1.67395985
30CBP_20019798_ChIP-Seq_JUKART_Human1.58566714
31IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58566714
32NR3C1_21868756_ChIP-Seq_MCF10A_Human1.57824347
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57549415
34AR_25329375_ChIP-Seq_VCAP_Human1.52015206
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51415085
36SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49401418
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49140259
38EZH2_27294783_Chip-Seq_NPCs_Mouse1.45678332
39TCF4_22108803_ChIP-Seq_LS180_Human1.44181653
40POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42848021
41TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42848021
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.42286308
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40986776
44SOX2_19829295_ChIP-Seq_ESCs_Human1.40123515
45NANOG_19829295_ChIP-Seq_ESCs_Human1.40123515
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.38473408
47EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.38423612
48KLF5_20875108_ChIP-Seq_MESCs_Mouse1.38095515
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36001500
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35315911
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34763618
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34376618
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34313140
54RUNX2_22187159_ChIP-Seq_PCA_Human1.33376271
55TP53_22573176_ChIP-Seq_HFKS_Human1.32414719
56AR_21572438_ChIP-Seq_LNCaP_Human1.31741826
57FLI1_21867929_ChIP-Seq_TH2_Mouse1.30589901
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30568428
59CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30372365
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30276855
61PRDM14_20953172_ChIP-Seq_ESCs_Human1.27743440
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25366769
63FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24684508
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.24386225
65CRX_20693478_ChIP-Seq_RETINA_Mouse1.23665842
66IRF1_19129219_ChIP-ChIP_H3396_Human1.23292061
67SMAD4_21741376_ChIP-Seq_EPCs_Human1.22664151
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22079856
69TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20399874
70CDX2_22108803_ChIP-Seq_LS180_Human1.20153066
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19185843
72FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16090282
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15171533
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14239939
75REST_21632747_ChIP-Seq_MESCs_Mouse1.14055900
76P53_22387025_ChIP-Seq_ESCs_Mouse1.12378913
77FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12144312
78FOXA1_25329375_ChIP-Seq_VCAP_Human1.12144312
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10216067
80E2F1_18555785_Chip-Seq_ESCs_Mouse1.08788150
81OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08330427
82STAT3_18555785_Chip-Seq_ESCs_Mouse1.08086908
83SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07440019
84RNF2_27304074_Chip-Seq_NSC_Mouse1.07198073
85TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06356801
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06317758
87SOX2_21211035_ChIP-Seq_LN229_Gbm1.05833591
88DROSHA_22980978_ChIP-Seq_HELA_Human1.04380828
89SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04366851
90KDM2B_26808549_Chip-Seq_REH_Human1.03159484
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.02386062
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02229147
93AR_20517297_ChIP-Seq_VCAP_Human1.02165557
94TP53_16413492_ChIP-PET_HCT116_Human1.01839911
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.01436940
96AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01091208
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.00546872
98ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00136775
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00066370
100P300_18555785_Chip-Seq_ESCs_Mouse1.00012721

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.62356230
2MP0000569_abnormal_digit_pigmentation3.29244184
3MP0005551_abnormal_eye_electrophysiolog2.85205269
4MP0000372_irregular_coat_pigmentation2.65318972
5MP0001501_abnormal_sleep_pattern2.52958874
6MP0004043_abnormal_pH_regulation2.51451727
7MP0003646_muscle_fatigue2.49197816
8MP0001968_abnormal_touch/_nociception2.39598648
9MP0009046_muscle_twitch2.31970420
10MP0008877_abnormal_DNA_methylation2.11644119
11MP0003136_yellow_coat_color2.11380351
12MP0002736_abnormal_nociception_after2.10744386
13MP0002102_abnormal_ear_morphology2.04750670
14MP0008057_abnormal_DNA_replication2.04369859
15MP0005253_abnormal_eye_physiology2.00692865
16MP0008872_abnormal_physiological_respon1.97543416
17MP0002837_dystrophic_cardiac_calcinosis1.96920074
18MP0006276_abnormal_autonomic_nervous1.81294151
19MP0005646_abnormal_pituitary_gland1.78709315
20MP0006072_abnormal_retinal_apoptosis1.75441656
21MP0005645_abnormal_hypothalamus_physiol1.74981671
22MP0009745_abnormal_behavioral_response1.74538176
23MP0001984_abnormal_olfaction1.69885085
24MP0003880_abnormal_central_pattern1.66085872
25MP0005174_abnormal_tail_pigmentation1.65841105
26MP0002938_white_spotting1.64267121
27MP0005670_abnormal_white_adipose1.62936410
28MP0000427_abnormal_hair_cycle1.56057548
29MP0004142_abnormal_muscle_tone1.52732434
30MP0001986_abnormal_taste_sensitivity1.50094027
31MP0004147_increased_porphyrin_level1.49943697
32MP0001486_abnormal_startle_reflex1.49090128
33MP0002638_abnormal_pupillary_reflex1.47993652
34MP0006292_abnormal_olfactory_placode1.47715096
35MP0002272_abnormal_nervous_system1.47123356
36MP0003252_abnormal_bile_duct1.44487591
37MP0005083_abnormal_biliary_tract1.43340141
38MP0000383_abnormal_hair_follicle1.43191380
39MP0001485_abnormal_pinna_reflex1.42855691
40MP0010386_abnormal_urinary_bladder1.42588060
41MP0003950_abnormal_plasma_membrane1.38745815
42MP0005167_abnormal_blood-brain_barrier1.37578798
43MP0000631_abnormal_neuroendocrine_gland1.36782398
44MP0003787_abnormal_imprinting1.36634779
45MP0005085_abnormal_gallbladder_physiolo1.35153730
46MP0002735_abnormal_chemical_nociception1.31062948
47MP0002572_abnormal_emotion/affect_behav1.29982752
48MP0005171_absent_coat_pigmentation1.29018084
49MP0002876_abnormal_thyroid_physiology1.26637252
50MP0001529_abnormal_vocalization1.24097372
51MP0002733_abnormal_thermal_nociception1.21401093
52MP0008058_abnormal_DNA_repair1.20269894
53MP0001970_abnormal_pain_threshold1.19903330
54MP0002557_abnormal_social/conspecific_i1.19460869
55MP0005386_behavior/neurological_phenoty1.16719009
56MP0004924_abnormal_behavior1.16719009
57MP0002067_abnormal_sensory_capabilities1.15496814
58MP0003718_maternal_effect1.14467615
59MP0002064_seizures1.13000814
60MP0004215_abnormal_myocardial_fiber1.12622669
61MP0004145_abnormal_muscle_electrophysio1.12279262
62MP0002095_abnormal_skin_pigmentation1.10953817
63MP0005075_abnormal_melanosome_morpholog1.10376402
64MP0008875_abnormal_xenobiotic_pharmacok1.09487946
65MP0004885_abnormal_endolymph1.06805286
66MP0003635_abnormal_synaptic_transmissio1.03948744
67MP0000230_abnormal_systemic_arterial1.00773744
68MP0002234_abnormal_pharynx_morphology1.00409296
69MP0009697_abnormal_copulation1.00011864
70MP0005084_abnormal_gallbladder_morpholo0.98170240
71MP0002928_abnormal_bile_duct0.97881416
72MP0005379_endocrine/exocrine_gland_phen0.96956878
73MP0005410_abnormal_fertilization0.96917299
74MP0002229_neurodegeneration0.94997712
75MP0005195_abnormal_posterior_eye0.92043490
76MP0008961_abnormal_basal_metabolism0.91196226
77MP0001963_abnormal_hearing_physiology0.89875483
78MP0005365_abnormal_bile_salt0.89392862
79MP0003698_abnormal_male_reproductive0.89276096
80MP0003878_abnormal_ear_physiology0.89071824
81MP0005377_hearing/vestibular/ear_phenot0.89071824
82MP0000538_abnormal_urinary_bladder0.88724898
83MP0002653_abnormal_ependyma_morphology0.88611049
84MP0008775_abnormal_heart_ventricle0.88012880
85MP0010329_abnormal_lipoprotein_level0.87938227
86MP0004742_abnormal_vestibular_system0.87670365
87MP0008995_early_reproductive_senescence0.87570689
88MP0002163_abnormal_gland_morphology0.86191244
89MP0000015_abnormal_ear_pigmentation0.84881799
90MP0001764_abnormal_homeostasis0.84761999
91MP0002752_abnormal_somatic_nervous0.84734020
92MP0001905_abnormal_dopamine_level0.83170292
93MP0003045_fibrosis0.81895121
94MP0002063_abnormal_learning/memory/cond0.80413542
95MP0002184_abnormal_innervation0.80413016
96MP0002168_other_aberrant_phenotype0.80014930
97MP0002160_abnormal_reproductive_system0.79181856
98MP0005310_abnormal_salivary_gland0.78337132
99MP0004085_abnormal_heartbeat0.78147077
100MP0000026_abnormal_inner_ear0.77725582

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.38692269
2Congenital stationary night blindness (HP:0007642)3.95866506
3Pancreatic fibrosis (HP:0100732)3.94162817
4Hyperventilation (HP:0002883)3.86054427
5True hermaphroditism (HP:0010459)3.83238281
6Molar tooth sign on MRI (HP:0002419)3.72541698
7Abnormality of midbrain morphology (HP:0002418)3.72541698
8Gaze-evoked nystagmus (HP:0000640)3.59565437
9Attenuation of retinal blood vessels (HP:0007843)3.51631207
10Nephronophthisis (HP:0000090)3.50914434
11Abnormality of the renal cortex (HP:0011035)3.50320413
12Medial flaring of the eyebrow (HP:0010747)3.40639035
13Abnormality of the renal medulla (HP:0100957)3.29137449
14Genetic anticipation (HP:0003743)3.20921657
15Progressive cerebellar ataxia (HP:0002073)3.00182552
16Chronic hepatic failure (HP:0100626)2.93638768
17Type II lissencephaly (HP:0007260)2.90868781
18Abolished electroretinogram (ERG) (HP:0000550)2.88445535
19Cystic liver disease (HP:0006706)2.85168188
20Gait imbalance (HP:0002141)2.81874870
21Protruding tongue (HP:0010808)2.78395868
22Congenital primary aphakia (HP:0007707)2.76694654
23Absent speech (HP:0001344)2.74866739
24Fair hair (HP:0002286)2.68333677
25Bony spicule pigmentary retinopathy (HP:0007737)2.61045634
26Febrile seizures (HP:0002373)2.60976325
27Polydipsia (HP:0001959)2.54624258
28Abnormal drinking behavior (HP:0030082)2.54624258
29Nephrogenic diabetes insipidus (HP:0009806)2.54362032
30Tubular atrophy (HP:0000092)2.53549522
31Aplasia/Hypoplasia of the tibia (HP:0005772)2.51676148
32Cerebellar dysplasia (HP:0007033)2.48716635
33Congenital sensorineural hearing impairment (HP:0008527)2.46735250
34Renal cortical cysts (HP:0000803)2.43773001
35Decreased central vision (HP:0007663)2.43760967
36Aplasia/Hypoplasia of the tongue (HP:0010295)2.43214710
37Clumsiness (HP:0002312)2.41364222
38Keratoconus (HP:0000563)2.41250877
39Increased corneal curvature (HP:0100692)2.41250877
40Inability to walk (HP:0002540)2.40314413
41Genital tract atresia (HP:0001827)2.38798909
42Congenital hepatic fibrosis (HP:0002612)2.33585081
43Vaginal atresia (HP:0000148)2.30961032
44Sclerocornea (HP:0000647)2.30958352
45Decreased electroretinogram (ERG) amplitude (HP:0000654)2.30054431
46Ketoacidosis (HP:0001993)2.28391298
47Large for gestational age (HP:0001520)2.27489716
48Broad-based gait (HP:0002136)2.26599786
49Abnormal rod and cone electroretinograms (HP:0008323)2.26591280
50Progressive inability to walk (HP:0002505)2.24926183
51Hypothermia (HP:0002045)2.24116045
52Abnormality of macular pigmentation (HP:0008002)2.20983334
53Lissencephaly (HP:0001339)2.18725612
54Generalized hypopigmentation of hair (HP:0011358)2.18407183
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.16850611
56Abnormality of alanine metabolism (HP:0010916)2.16850611
57Hyperalaninemia (HP:0003348)2.16850611
58Decreased circulating renin level (HP:0003351)2.16814015
59Furrowed tongue (HP:0000221)2.16053142
60Postaxial foot polydactyly (HP:0001830)2.14669594
61Polyuria (HP:0000103)2.11521784
62Widely spaced teeth (HP:0000687)2.09598942
63Stomach cancer (HP:0012126)2.08199240
64Central scotoma (HP:0000603)2.06782250
65Bile duct proliferation (HP:0001408)2.00013102
66Abnormal biliary tract physiology (HP:0012439)2.00013102
67Intestinal atresia (HP:0011100)1.99703509
68Anencephaly (HP:0002323)1.99269145
69Poor coordination (HP:0002370)1.97556911
70Ketosis (HP:0001946)1.94489186
71Astigmatism (HP:0000483)1.92709552
72Pendular nystagmus (HP:0012043)1.92599506
73Focal seizures (HP:0007359)1.90934562
74Tubulointerstitial nephritis (HP:0001970)1.90170405
75Small hand (HP:0200055)1.90072465
76Abnormality of the pons (HP:0007361)1.89437801
77Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.89039112
78Constricted visual fields (HP:0001133)1.88397060
79Dialeptic seizures (HP:0011146)1.86221800
80Hemiparesis (HP:0001269)1.84811995
81Absent rod-and cone-mediated responses on ERG (HP:0007688)1.84277372
82Retinitis pigmentosa (HP:0000510)1.84238835
83Retinal dysplasia (HP:0007973)1.83377690
84Short foot (HP:0001773)1.83162770
85Hypoplasia of the pons (HP:0012110)1.83100986
86Tubulointerstitial abnormality (HP:0001969)1.81659050
87Postaxial hand polydactyly (HP:0001162)1.81363274
88Aplasia/Hypoplasia of the fovea (HP:0008060)1.80391105
89Hypoplasia of the fovea (HP:0007750)1.80391105
90Increased neuronal autofluorescent lipopigment (HP:0002074)1.79559119
91Methylmalonic acidemia (HP:0002912)1.77288983
92Chorioretinal atrophy (HP:0000533)1.76777592
93Methylmalonic aciduria (HP:0012120)1.76219172
94Male pseudohermaphroditism (HP:0000037)1.76196082
95Absent/shortened dynein arms (HP:0200106)1.75860195
96Dynein arm defect of respiratory motile cilia (HP:0012255)1.75860195
97Colon cancer (HP:0003003)1.74817589
98Aplasia/Hypoplasia of the uvula (HP:0010293)1.68437408
99Neoplasm of the adrenal cortex (HP:0100641)1.67325795
100Preaxial hand polydactyly (HP:0001177)1.66720211

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.14436812
2BMPR1B3.06855977
3MAP4K22.94980731
4ACVR1B2.77670305
5ADRBK22.66721881
6NUAK12.65919151
7INSRR2.40400845
8WNK32.25567722
9ZAK2.10870452
10GRK12.08019246
11MAPK131.86228930
12CASK1.79463764
13STK38L1.72019393
14TAOK31.63682300
15MAP3K41.58617063
16MKNK21.48126758
17CCNB11.48112802
18WNK41.47055311
19PINK11.42705680
20TNIK1.40703414
21CAMKK21.39948235
22TRIM281.35823200
23STK391.31033687
24OXSR11.26891678
25LATS11.23626023
26PIK3CG1.20108833
27MUSK1.14498808
28NTRK31.13421772
29BRSK21.10079973
30NEK21.09721351
31ADRBK11.06761396
32AKT31.05705645
33STK31.02923843
34PTK2B1.02034397
35PAK31.01681327
36TIE10.99812386
37TAF10.99062197
38PRKCE0.98796839
39DAPK20.97889737
40TEC0.94097991
41TXK0.91320987
42VRK10.89225325
43BCR0.87251332
44PLK20.86386996
45VRK20.85366110
46CSNK1G10.85324546
47CSNK1G20.85041119
48CSNK1A1L0.84130008
49MAPKAPK50.83171841
50TNK20.80895633
51MARK10.80857267
52CSNK1G30.80819755
53TGFBR10.80650856
54PRKCG0.80413849
55CAMK1D0.79812901
56FER0.74472558
57MKNK10.74099646
58MAP2K70.71003332
59ERBB30.70692508
60EPHA40.68300652
61CAMK1G0.63395989
62PRKAA20.63292130
63MST40.63096131
64EIF2AK30.61150309
65FGFR20.57829460
66PKN10.57603555
67CAMK10.55398662
68PNCK0.54710340
69PIK3CA0.54244499
70IRAK10.54219530
71GRK50.54189774
72NLK0.53475371
73PLK30.52510342
74PLK40.51228014
75FLT30.50510551
76TLK10.48788576
77CAMK2A0.48327908
78KIT0.48121328
79MAP3K70.46940321
80DYRK20.46884567
81WEE10.45620259
82CHUK0.45247273
83OBSCN0.44853447
84IKBKB0.42747357
85PRKAA10.39220691
86PRKACA0.38098936
87CSNK1D0.37850761
88PRKCQ0.36295705
89MAPKAPK30.35358841
90TRPM70.35206845
91CSNK1A10.33884546
92PHKG20.32804601
93PHKG10.32804601
94CHEK20.30964398
95PRKCA0.29940701
96CAMK40.29451819
97ATM0.28297988
98MELK0.28245554
99MARK30.28089245
100PDK20.26712329

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.16924413
2Butanoate metabolism_Homo sapiens_hsa006502.91580864
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.64796283
4Nicotine addiction_Homo sapiens_hsa050332.55965834
5Linoleic acid metabolism_Homo sapiens_hsa005912.39817311
6Nitrogen metabolism_Homo sapiens_hsa009102.38407431
7Tryptophan metabolism_Homo sapiens_hsa003802.30079618
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.26561735
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.25871410
10Homologous recombination_Homo sapiens_hsa034402.25264250
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15011426
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.12854519
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.12350306
14ABC transporters_Homo sapiens_hsa020101.93563511
15Olfactory transduction_Homo sapiens_hsa047401.81030938
16Ether lipid metabolism_Homo sapiens_hsa005651.78742070
17Taste transduction_Homo sapiens_hsa047421.75371458
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69520371
19Selenocompound metabolism_Homo sapiens_hsa004501.67885068
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.67542561
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.65894292
22Propanoate metabolism_Homo sapiens_hsa006401.63444185
23Morphine addiction_Homo sapiens_hsa050321.63441432
24Basal transcription factors_Homo sapiens_hsa030221.62477511
25Fanconi anemia pathway_Homo sapiens_hsa034601.59395975
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.55970377
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.54355299
28Caffeine metabolism_Homo sapiens_hsa002321.51769086
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49977131
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.44891863
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.41115117
32Circadian entrainment_Homo sapiens_hsa047131.30617129
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.28485685
34Glutamatergic synapse_Homo sapiens_hsa047241.26459768
35Retinol metabolism_Homo sapiens_hsa008301.24952052
36GABAergic synapse_Homo sapiens_hsa047271.24040903
37Serotonergic synapse_Homo sapiens_hsa047261.22410957
38Chemical carcinogenesis_Homo sapiens_hsa052041.21672680
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.19739010
40Glycerolipid metabolism_Homo sapiens_hsa005611.18260582
41Arachidonic acid metabolism_Homo sapiens_hsa005901.13260040
42Protein export_Homo sapiens_hsa030601.13089030
43Salivary secretion_Homo sapiens_hsa049701.13009619
44Insulin secretion_Homo sapiens_hsa049111.11098641
45beta-Alanine metabolism_Homo sapiens_hsa004101.09830931
46Ovarian steroidogenesis_Homo sapiens_hsa049131.02467158
47Calcium signaling pathway_Homo sapiens_hsa040201.02185115
48One carbon pool by folate_Homo sapiens_hsa006701.00063352
49Peroxisome_Homo sapiens_hsa041460.98319766
50Regulation of autophagy_Homo sapiens_hsa041400.96023010
51Histidine metabolism_Homo sapiens_hsa003400.95520445
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93751545
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86553584
54Lysine degradation_Homo sapiens_hsa003100.82005501
55RNA polymerase_Homo sapiens_hsa030200.81057859
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.77241597
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.76169235
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.75437382
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74401259
60Non-homologous end-joining_Homo sapiens_hsa034500.73941818
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70513504
62RNA degradation_Homo sapiens_hsa030180.67928472
63Sphingolipid metabolism_Homo sapiens_hsa006000.67237330
64Circadian rhythm_Homo sapiens_hsa047100.65095476
65Long-term depression_Homo sapiens_hsa047300.64892931
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64154961
67Fatty acid degradation_Homo sapiens_hsa000710.61971106
68Glycerophospholipid metabolism_Homo sapiens_hsa005640.61825689
69Collecting duct acid secretion_Homo sapiens_hsa049660.60480985
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58156632
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57185704
72Oxidative phosphorylation_Homo sapiens_hsa001900.56203857
73Dopaminergic synapse_Homo sapiens_hsa047280.55079512
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53503936
75Fat digestion and absorption_Homo sapiens_hsa049750.53357010
76Metabolic pathways_Homo sapiens_hsa011000.52768463
77Renin secretion_Homo sapiens_hsa049240.51436696
78Purine metabolism_Homo sapiens_hsa002300.51040282
79Cholinergic synapse_Homo sapiens_hsa047250.49880347
80Asthma_Homo sapiens_hsa053100.48524170
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45249987
82Pancreatic secretion_Homo sapiens_hsa049720.43022125
83Oxytocin signaling pathway_Homo sapiens_hsa049210.42157971
84cAMP signaling pathway_Homo sapiens_hsa040240.41450611
85Dorso-ventral axis formation_Homo sapiens_hsa043200.40707965
86Sulfur metabolism_Homo sapiens_hsa009200.39057913
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.38263856
88Gastric acid secretion_Homo sapiens_hsa049710.37053636
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36666697
90Primary immunodeficiency_Homo sapiens_hsa053400.35570001
91Cocaine addiction_Homo sapiens_hsa050300.34076600
92Type II diabetes mellitus_Homo sapiens_hsa049300.32470302
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31577843
94Type I diabetes mellitus_Homo sapiens_hsa049400.28231432
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27903555
96Mineral absorption_Homo sapiens_hsa049780.27678825
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26841365
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.26790812
99Fatty acid metabolism_Homo sapiens_hsa012120.26685249
100Amphetamine addiction_Homo sapiens_hsa050310.26152021

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