C2ORF82

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cholesterol esterification (GO:0010872)6.68116273
2plasma lipoprotein particle assembly (GO:0034377)6.20611391
3very-low-density lipoprotein particle assembly (GO:0034379)6.14293652
4protein-lipid complex remodeling (GO:0034368)5.75311029
5macromolecular complex remodeling (GO:0034367)5.75311029
6plasma lipoprotein particle remodeling (GO:0034369)5.75311029
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.68551944
8high-density lipoprotein particle remodeling (GO:0034375)5.67605550
9protein-lipid complex assembly (GO:0065005)5.66166902
10negative regulation of fibrinolysis (GO:0051918)5.54512943
11low-density lipoprotein particle remodeling (GO:0034374)5.47158542
12phospholipid efflux (GO:0033700)5.42181708
13cholesterol efflux (GO:0033344)5.35278919
14negative regulation of cholesterol transport (GO:0032375)5.25418976
15negative regulation of sterol transport (GO:0032372)5.25418976
16protein carboxylation (GO:0018214)5.20718355
17peptidyl-glutamic acid carboxylation (GO:0017187)5.20718355
18reverse cholesterol transport (GO:0043691)5.19300909
19plasma lipoprotein particle organization (GO:0071827)4.92558733
20regulation of fibrinolysis (GO:0051917)4.91744898
21plasma lipoprotein particle clearance (GO:0034381)4.90811408
22protein-lipid complex subunit organization (GO:0071825)4.70622506
23regulation of bile acid biosynthetic process (GO:0070857)4.63830130
24regulation of cholesterol homeostasis (GO:2000188)4.40344983
25neurotransmitter-gated ion channel clustering (GO:0072578)4.38270908
26regulation of plasminogen activation (GO:0010755)4.32906961
27regulation of cholesterol biosynthetic process (GO:0045540)4.32666912
28intestinal cholesterol absorption (GO:0030299)4.24684251
29erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.07093233
30L-phenylalanine catabolic process (GO:0006559)4.07093233
31proline metabolic process (GO:0006560)4.05860371
32central nervous system myelination (GO:0022010)4.05101531
33axon ensheathment in central nervous system (GO:0032291)4.05101531
34erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.04191640
35L-phenylalanine metabolic process (GO:0006558)4.04191640
36positive regulation of fatty acid biosynthetic process (GO:0045723)4.04177810
37positive regulation of triglyceride lipase activity (GO:0061365)4.04151480
38positive regulation of lipoprotein lipase activity (GO:0051006)4.04151480
39regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.01738001
40lung epithelium development (GO:0060428)3.99182401
41regulation of protein activation cascade (GO:2000257)3.95508399
42regulation of complement activation (GO:0030449)3.88792357
43positive regulation of steroid metabolic process (GO:0045940)3.87146096
44regulation of apoptotic cell clearance (GO:2000425)3.81197096
45negative regulation of lipase activity (GO:0060192)3.74473482
46glutamate metabolic process (GO:0006536)3.60351257
47cellular sodium ion homeostasis (GO:0006883)3.54842809
48regulation of cholesterol metabolic process (GO:0090181)3.43764495
49diacylglycerol metabolic process (GO:0046339)3.42139630
50positive regulation of synapse maturation (GO:0090129)3.42110463
51triglyceride homeostasis (GO:0070328)3.40126400
52acylglycerol homeostasis (GO:0055090)3.40126400
53lipoprotein metabolic process (GO:0042157)3.37593414
54renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.34524415
55blood coagulation, intrinsic pathway (GO:0007597)3.23802865
56fibrinolysis (GO:0042730)3.23603220
57intestinal absorption (GO:0050892)3.20577695
58positive regulation of dendritic spine development (GO:0060999)3.18876418
59negative regulation of blood coagulation (GO:0030195)3.17379006
60negative regulation of hemostasis (GO:1900047)3.17379006
61regulation of extracellular matrix disassembly (GO:0010715)3.15448213
62sterol transport (GO:0015918)3.15409097
63cholesterol transport (GO:0030301)3.15409097
64positive regulation of dendritic spine morphogenesis (GO:0061003)3.14778450
65synaptic vesicle docking involved in exocytosis (GO:0016081)3.10470953
66negative regulation of lipid transport (GO:0032369)3.08982317
67positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.08537450
68cholesterol homeostasis (GO:0042632)3.07002232
69regulation of extracellular matrix organization (GO:1903053)3.06485003
70positive regulation of extracellular matrix organization (GO:1903055)3.01240944
71glutamate secretion (GO:0014047)3.01197094
72sterol homeostasis (GO:0055092)3.00905138
73negative regulation of sodium ion transport (GO:0010766)2.94035150
74regulation of glycogen (starch) synthase activity (GO:2000465)2.92536070
75regulation of lipoprotein particle clearance (GO:0010984)2.91145559
76sodium ion export (GO:0071436)2.90015713
77regulation of fatty acid biosynthetic process (GO:0042304)2.88512618
78complement activation, alternative pathway (GO:0006957)2.88340358
79synaptic vesicle exocytosis (GO:0016079)2.87244662
80cellular potassium ion homeostasis (GO:0030007)2.87014164
81regulation of synapse maturation (GO:0090128)2.86986702
82negative regulation of coagulation (GO:0050819)2.85662521
83sodium ion homeostasis (GO:0055078)2.84203830
84C4-dicarboxylate transport (GO:0015740)2.83287348
85vitamin transmembrane transport (GO:0035461)2.82355344
86positive regulation of lipid catabolic process (GO:0050996)2.82044784
87vocalization behavior (GO:0071625)2.81201034
88cellular zinc ion homeostasis (GO:0006882)2.78298118
89cell-cell junction maintenance (GO:0045217)2.77720491
90regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.76331336
91drinking behavior (GO:0042756)2.72694701
92proline biosynthetic process (GO:0006561)2.72373158
93embryonic retina morphogenesis in camera-type eye (GO:0060059)2.71091077
94acute-phase response (GO:0006953)2.69433057
95short-term memory (GO:0007614)2.66830568
96negative regulation of wound healing (GO:0061045)2.65624198
97layer formation in cerebral cortex (GO:0021819)2.64958726
98artery smooth muscle contraction (GO:0014824)2.64293334
99amino acid import (GO:0043090)2.61644892
100dicarboxylic acid biosynthetic process (GO:0043650)2.59326065

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.32016786
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.73007675
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.26114018
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.11024342
5PPARA_22158963_ChIP-Seq_LIVER_Mouse2.80519707
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.55188694
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.53914955
8* LXR_22292898_ChIP-Seq_THP-1_Human2.51897241
9DROSHA_22980978_ChIP-Seq_HELA_Human2.40027847
10FOXA2_19822575_ChIP-Seq_HepG2_Human2.35922495
11ERG_21242973_ChIP-ChIP_JURKAT_Human2.35744395
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.32219725
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.16931403
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.16193530
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.10030032
16CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.01839754
17RARB_27405468_Chip-Seq_BRAIN_Mouse1.95967563
18* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.94879870
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87710658
20RARG_19884340_ChIP-ChIP_MEFs_Mouse1.85146078
21KDM2B_26808549_Chip-Seq_K562_Human1.81609488
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.78821091
23CTCF_27219007_Chip-Seq_Bcells_Human1.78011698
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77575617
25SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.77417619
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76250534
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.74320587
28HNF4A_19822575_ChIP-Seq_HepG2_Human1.73911201
29ZNF263_19887448_ChIP-Seq_K562_Human1.69729467
30EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.69470598
31REST_21632747_ChIP-Seq_MESCs_Mouse1.66431155
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.64158373
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.62950652
34SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.61233759
35P68_20966046_ChIP-Seq_HELA_Human1.61210388
36MTF2_20144788_ChIP-Seq_MESCs_Mouse1.60292838
37SMC4_20622854_ChIP-Seq_HELA_Human1.59357284
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.55560673
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.53154623
40CDX2_20551321_ChIP-Seq_CACO-2_Human1.48498713
41RNF2_18974828_ChIP-Seq_MESCs_Mouse1.48129432
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.48129432
43RACK7_27058665_Chip-Seq_MCF-7_Human1.45527171
44ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42857797
45JARID2_20064375_ChIP-Seq_MESCs_Mouse1.41789817
46CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.40847325
47RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.40278045
48SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.39782212
49REST_18959480_ChIP-ChIP_MESCs_Mouse1.39170514
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.37731962
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37434448
52UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33358015
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31976774
54ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31328114
55RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30675070
56SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25952726
57SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.25538167
58PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.24531138
59RNF2_27304074_Chip-Seq_ESCs_Mouse1.21077165
60TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.19292348
61SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.17757677
62HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16869047
63EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16545883
64SA1_27219007_Chip-Seq_Bcells_Human1.16018148
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15954841
66ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15750787
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14013820
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12658789
69STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.12647185
70CREB1_26743006_Chip-Seq_LNCaP_Human1.12604492
71OCT4_19829295_ChIP-Seq_ESCs_Human1.11700634
72SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10958252
73SA1_27219007_Chip-Seq_ERYTHROID_Human1.10030496
74ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09073593
75TET1_21490601_ChIP-Seq_MESCs_Mouse1.08555828
76NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.08532315
77GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.08275488
78MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07807893
79SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.07393125
80EZH2_22144423_ChIP-Seq_EOC_Human1.06608766
81ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05898581
82SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03886486
83OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.03380780
84* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03270036
85BCOR_27268052_Chip-Seq_Bcells_Human1.02638558
86RARA_24833708_ChIP-Seq_LIVER_Mouse1.00822457
87RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00769946
88NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00611637
89CLOCK_20551151_ChIP-Seq_293T_Human1.00325625
90RARB_24833708_ChIP-Seq_LIVER_Mouse1.00281875
91TP53_22127205_ChIP-Seq_IMR90_Human1.00248608
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99186322
93TP63_22573176_ChIP-Seq_HFKS_Human0.98068022
94SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.98016923
95MYC_19915707_ChIP-ChIP_AK7_Human0.97482466
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96826268
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.96816095
98KLF4_19829295_ChIP-Seq_ESCs_Human0.95771468
99CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94138140
100PHF8_20622854_ChIP-Seq_HELA_Human0.92719526

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.72744559
2MP0002139_abnormal_hepatobiliary_system4.96052580
3MP0005365_abnormal_bile_salt4.32360040
4MP0000566_synostosis3.78455677
5MP0003122_maternal_imprinting3.58755195
6MP0003195_calcinosis3.17470674
7MP0010329_abnormal_lipoprotein_level3.12806873
8MP0004859_abnormal_synaptic_plasticity2.90371206
9MP0009840_abnormal_foam_cell2.79929912
10MP0001666_abnormal_nutrient_absorption2.76126105
11MP0005085_abnormal_gallbladder_physiolo2.54490849
12MP0004270_analgesia2.54311689
13MP0003879_abnormal_hair_cell2.48305102
14MP0009780_abnormal_chondrocyte_physiolo2.45212611
15MP0003329_amyloid_beta_deposits2.44047381
16MP0003123_paternal_imprinting2.33985381
17MP0002089_abnormal_postnatal_growth/wei2.27475843
18MP0003172_abnormal_lysosome_physiology2.26621466
19MP0005423_abnormal_somatic_nervous2.21945295
20MP0008875_abnormal_xenobiotic_pharmacok2.13339794
21MP0002064_seizures2.10722097
22MP0003880_abnormal_central_pattern1.97383813
23MP0003635_abnormal_synaptic_transmissio1.87924295
24MP0003868_abnormal_feces_composition1.84843979
25MP0005167_abnormal_blood-brain_barrier1.79227995
26MP0005646_abnormal_pituitary_gland1.73100218
27MP0000920_abnormal_myelination1.66419796
28MP0001486_abnormal_startle_reflex1.66172419
29MP0000604_amyloidosis1.60723210
30MP0005409_darkened_coat_color1.59646346
31MP0003690_abnormal_glial_cell1.57015576
32MP0002063_abnormal_learning/memory/cond1.54432311
33MP0005332_abnormal_amino_acid1.42808788
34MP0005451_abnormal_body_composition1.41102202
35MP0002572_abnormal_emotion/affect_behav1.40076991
36MP0002118_abnormal_lipid_homeostasis1.39962716
37MP0003252_abnormal_bile_duct1.38040615
38MP0002272_abnormal_nervous_system1.37535579
39MP0009745_abnormal_behavioral_response1.30883041
40MP0002876_abnormal_thyroid_physiology1.30217554
41MP0002734_abnormal_mechanical_nocicepti1.30111029
42MP0004264_abnormal_extraembryonic_tissu1.29313388
43MP0008569_lethality_at_weaning1.23638577
44MP0002735_abnormal_chemical_nociception1.22876213
45MP0003633_abnormal_nervous_system1.22092590
46MP0002909_abnormal_adrenal_gland1.18456804
47MP0005058_abnormal_lysosome_morphology1.16942799
48MP0000609_abnormal_liver_physiology1.09326127
49MP0003631_nervous_system_phenotype1.08636920
50MP0004019_abnormal_vitamin_homeostasis1.08380134
51MP0009046_muscle_twitch1.06940145
52MP0003878_abnormal_ear_physiology1.05299381
53MP0005377_hearing/vestibular/ear_phenot1.05299381
54MP0003632_abnormal_nervous_system1.04505118
55MP0000639_abnormal_adrenal_gland1.02242301
56MP0001501_abnormal_sleep_pattern0.99761928
57MP0003191_abnormal_cellular_cholesterol0.98311407
58MP0002557_abnormal_social/conspecific_i0.96613074
59MP0004742_abnormal_vestibular_system0.94647628
60MP0003634_abnormal_glial_cell0.93568066
61MP0001970_abnormal_pain_threshold0.92550906
62MP0004885_abnormal_endolymph0.92314433
63MP0005670_abnormal_white_adipose0.91451539
64MP0001984_abnormal_olfaction0.91297986
65MP0002733_abnormal_thermal_nociception0.89753183
66MP0000003_abnormal_adipose_tissue0.88747176
67MP0005448_abnormal_energy_balance0.85007807
68MP0001968_abnormal_touch/_nociception0.83994251
69MP0003075_altered_response_to0.82996456
70MP0002249_abnormal_larynx_morphology0.82123724
71MP0003183_abnormal_peptide_metabolism0.76125229
72MP0005636_abnormal_mineral_homeostasis0.75978877
73MP0002971_abnormal_brown_adipose0.75515700
74MP0002066_abnormal_motor_capabilities/c0.75379790
75MP0005084_abnormal_gallbladder_morpholo0.74414678
76MP0001502_abnormal_circadian_rhythm0.73526372
77MP0002067_abnormal_sensory_capabilities0.73211485
78MP0002229_neurodegeneration0.72712883
79MP0001915_intracranial_hemorrhage0.72109812
80MP0003567_abnormal_fetal_cardiomyocyte0.70481766
81MP0002138_abnormal_hepatobiliary_system0.70077579
82MP0000955_abnormal_spinal_cord0.69782327
83MP0005551_abnormal_eye_electrophysiolog0.67965860
84MP0002882_abnormal_neuron_morphology0.66447630
85MP0002078_abnormal_glucose_homeostasis0.66344539
86MP0009643_abnormal_urine_homeostasis0.65248841
87MP0001765_abnormal_ion_homeostasis0.64405475
88MP0003953_abnormal_hormone_level0.62315667
89MP0001346_abnormal_lacrimal_gland0.60972941
90MP0001756_abnormal_urination0.59848913
91MP0009642_abnormal_blood_homeostasis0.58080007
92MP0003115_abnormal_respiratory_system0.57989981
93MP0005379_endocrine/exocrine_gland_phen0.57098768
94MP0004811_abnormal_neuron_physiology0.56617212
95MP0004130_abnormal_muscle_cell0.56341887
96MP0001299_abnormal_eye_distance/0.55228366
97MP0001963_abnormal_hearing_physiology0.54935965
98MP0002822_catalepsy0.54737533
99MP0009115_abnormal_fat_cell0.54268684
100MP0001764_abnormal_homeostasis0.53553894

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)8.53147668
2Joint hemorrhage (HP:0005261)5.34286910
3Prolonged partial thromboplastin time (HP:0003645)5.04756380
4Hypobetalipoproteinemia (HP:0003563)4.96938534
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.76385871
6Xanthomatosis (HP:0000991)4.64639477
7Hemorrhage of the eye (HP:0011885)4.56654357
8Complement deficiency (HP:0004431)4.05141168
9Hypercholesterolemia (HP:0003124)3.71318218
10Alacrima (HP:0000522)3.65850511
11Neurofibrillary tangles (HP:0002185)3.55412495
12Menstrual irregularities (HP:0000858)3.53405738
13Abnormality of monocarboxylic acid metabolism (HP:0010996)3.47929402
14Glomerulonephritis (HP:0000099)3.45211691
15Systemic lupus erythematosus (HP:0002725)3.34950903
16Hypolipoproteinemia (HP:0010981)3.33966475
17Abnormality of carpal bone ossification (HP:0006257)3.31987958
18Flat acetabular roof (HP:0003180)3.30836922
19Myokymia (HP:0002411)3.18519101
20Obstructive sleep apnea (HP:0002870)3.15473743
21Abnormality of complement system (HP:0005339)3.02300572
22Stridor (HP:0010307)2.94211711
23Growth hormone excess (HP:0000845)2.82203081
24Upper limb amyotrophy (HP:0009129)2.80054928
25Distal upper limb amyotrophy (HP:0007149)2.80054928
26Action tremor (HP:0002345)2.78754211
27Bronchomalacia (HP:0002780)2.77050828
28Cerebral inclusion bodies (HP:0100314)2.75461602
29Hand muscle atrophy (HP:0009130)2.74957868
30Mitral stenosis (HP:0001718)2.74940954
31Hypoalphalipoproteinemia (HP:0003233)2.70659778
32Abnormal ossification of hand bones (HP:0005921)2.64983561
33Menorrhagia (HP:0000132)2.63074891
34Abnormal hand bone ossification (HP:0010660)2.57637485
35Asymmetry of the thorax (HP:0001555)2.57171130
36Decreased lacrimation (HP:0000633)2.52934560
37Epiphyseal dysplasia (HP:0002656)2.52205255
38Vascular calcification (HP:0004934)2.51231859
39Abnormality of the common coagulation pathway (HP:0010990)2.43605366
40Late onset (HP:0003584)2.37753807
41Focal motor seizures (HP:0011153)2.33805256
42Hyperglycinemia (HP:0002154)2.31029396
43Purpura (HP:0000979)2.30069433
44Supranuclear gaze palsy (HP:0000605)2.29600321
45Diaphragmatic weakness (HP:0009113)2.29239805
46Hyperlipoproteinemia (HP:0010980)2.28748467
47Epileptic encephalopathy (HP:0200134)2.28612864
48Spontaneous abortion (HP:0005268)2.27295873
49Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.24980749
50Aplasia of the phalanges of the hand (HP:0009802)2.24655018
51Aplasia involving bones of the extremities (HP:0009825)2.24655018
52Aplasia involving bones of the upper limbs (HP:0009823)2.24655018
53Ankle clonus (HP:0011448)2.24058627
54Delayed CNS myelination (HP:0002188)2.19949316
55Potter facies (HP:0002009)2.18829925
56Facial shape deformation (HP:0011334)2.18829925
57Akinesia (HP:0002304)2.15352991
58Diplopia (HP:0000651)2.11693490
59Abnormality of binocular vision (HP:0011514)2.11693490
60Abnormality of pain sensation (HP:0010832)2.10852751
61Impaired pain sensation (HP:0007328)2.10852751
62Hypophosphatemic rickets (HP:0004912)2.10507916
63Focal seizures (HP:0007359)2.08861952
64Partial duplication of thumb phalanx (HP:0009944)2.08724157
65Epidermoid cyst (HP:0200040)2.07558869
66Acanthocytosis (HP:0001927)2.07115060
67Abnormality of the middle phalanges of the toes (HP:0010183)2.06291207
68Cardiovascular calcification (HP:0011915)2.05590033
69Bifid scrotum (HP:0000048)2.02586652
70Abnormal tarsal ossification (HP:0008369)2.01988776
71Neonatal death (HP:0003811)2.01776378
72Torticollis (HP:0000473)2.00681969
73Abnormality of glutamine family amino acid metabolism (HP:0010902)1.97613016
74Sleep apnea (HP:0010535)1.94234951
75Abnormality of the musculature of the hand (HP:0001421)1.93341057
76Small epiphyses (HP:0010585)1.92905140
77Conjugated hyperbilirubinemia (HP:0002908)1.88032384
78Intrahepatic cholestasis (HP:0001406)1.87721533
79Abnormality of serine family amino acid metabolism (HP:0010894)1.85923364
80Abnormality of glycine metabolism (HP:0010895)1.85923364
81Focal dystonia (HP:0004373)1.85844769
82Hydroxyprolinuria (HP:0003080)1.84878771
83Abnormality of proline metabolism (HP:0010907)1.84878771
84Neonatal short-limb short stature (HP:0008921)1.84216174
85Abnormality of the Achilles tendon (HP:0005109)1.83872321
86Amyloidosis (HP:0011034)1.83748607
87Confusion (HP:0001289)1.83156778
88Status epilepticus (HP:0002133)1.82202720
89Spinal cord compression (HP:0002176)1.81970538
90Megalencephaly (HP:0001355)1.81753049
91Craniofacial dystonia (HP:0012179)1.81706317
92Short femoral neck (HP:0100864)1.77037003
93Widely patent fontanelles and sutures (HP:0004492)1.77032033
94Dysmetria (HP:0001310)1.76980729
95Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.76546378
96Paraparesis (HP:0002385)1.76210889
97Fat malabsorption (HP:0002630)1.71661929
98Rickets (HP:0002748)1.71525356
99Nephritis (HP:0000123)1.70862880
100Lower limb asymmetry (HP:0100559)1.68475116

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR45.65021926
2EPHA43.93696517
3ICK3.06693203
4TRIB33.00623065
5NTRK32.91689380
6TYRO32.91668554
7RIPK12.91098276
8CAMKK12.63701385
9FGFR32.46335763
10ERN12.36253044
11CAMKK22.25088090
12SIK22.04783488
13PRKD31.98135684
14FGFR21.87933858
15SIK11.84314524
16DAPK21.72435972
17WNK41.64721574
18CDK121.59209781
19MAP3K111.54558406
20DDR21.46111636
21PDGFRA1.45898913
22PAK61.41892609
23PKN21.37722213
24LMTK21.37029801
25NTRK21.36462676
26EPHA21.34065130
27NTRK11.31278478
28MARK11.29227473
29UHMK11.28804260
30TNK21.26277073
31MARK21.26085550
32PIK3CA1.24634723
33DYRK1B1.19272851
34SGK2231.17776680
35SGK4941.17776680
36CDC42BPA1.16588144
37MINK11.15466979
38RET1.07646674
39PDPK11.06281745
40CAMK1D1.04802337
41SGK11.00649741
42PRKCG1.00261992
43CAMK40.99525082
44MST1R0.94673850
45PTK60.94007488
46ALK0.92796995
47FGFR10.87977475
48CAMK10.86406164
49BMX0.86003671
50CASK0.84899348
51ERBB20.80906933
52CDK50.80451980
53MAPK110.79215431
54MAP3K10.77926298
55PHKG20.77212670
56PHKG10.77212670
57PRKG20.76841961
58PRKCZ0.75134432
59MET0.75014866
60PDK10.74617899
61SGK30.74017374
62MAPK130.71899711
63KSR20.67820982
64EEF2K0.64878544
65MAP2K60.64708014
66SGK20.62670769
67DAPK10.62663371
68CAMK2B0.62441305
69IRAK30.61702692
70EPHB10.61355045
71WNK10.61231060
72PRKAA20.60017848
73MAP3K70.57558665
74CAMK1G0.56381339
75STK380.55344834
76TAOK10.54690996
77CDK150.54427473
78GRK50.53195934
79SMG10.52925264
80CAMK2G0.52452473
81PTK20.50113849
82RPS6KA30.50087210
83CDK11A0.50017017
84CSNK1E0.49513086
85MAPK100.49439052
86BRSK10.49299512
87CDK180.48167135
88PRKAA10.45852270
89PRKD20.45264161
90MAP3K20.45173550
91CAMK2A0.44883299
92PRPF4B0.44754962
93SRC0.43125930
94LATS20.42594819
95CAMK2D0.40298004
96CDK140.39747136
97PRKCH0.37553703
98PRKACG0.37343504
99MAPK80.37084485
100MTOR0.32557771

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046103.59374414
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.44067555
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.93962443
4Histidine metabolism_Homo sapiens_hsa003402.71164443
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.62364335
6Arginine biosynthesis_Homo sapiens_hsa002202.48006510
7Fat digestion and absorption_Homo sapiens_hsa049752.23322258
8Bile secretion_Homo sapiens_hsa049762.17250814
9Arginine and proline metabolism_Homo sapiens_hsa003302.09098939
10Vitamin B6 metabolism_Homo sapiens_hsa007502.05389828
11PPAR signaling pathway_Homo sapiens_hsa033202.02442657
12Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.95965910
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.84892668
14Vitamin digestion and absorption_Homo sapiens_hsa049771.84037811
15Phenylalanine metabolism_Homo sapiens_hsa003601.82110160
16Other glycan degradation_Homo sapiens_hsa005111.72162268
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.71728857
18Sulfur relay system_Homo sapiens_hsa041221.71005005
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.57646184
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.57037690
21Fatty acid degradation_Homo sapiens_hsa000711.42516453
22Nicotine addiction_Homo sapiens_hsa050331.34943487
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32904090
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.31673690
25Thyroid hormone synthesis_Homo sapiens_hsa049181.28056934
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23661463
27Fatty acid biosynthesis_Homo sapiens_hsa000611.23384892
28Synaptic vesicle cycle_Homo sapiens_hsa047211.21257315
29Glutamatergic synapse_Homo sapiens_hsa047241.19825328
30Long-term potentiation_Homo sapiens_hsa047201.18515408
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.17422801
32ABC transporters_Homo sapiens_hsa020101.14331718
33Fatty acid metabolism_Homo sapiens_hsa012121.13458241
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10664055
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09107960
36Fructose and mannose metabolism_Homo sapiens_hsa000511.03442222
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.02974823
38Mineral absorption_Homo sapiens_hsa049781.02831737
39Insulin secretion_Homo sapiens_hsa049111.02696217
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.02237287
41Amphetamine addiction_Homo sapiens_hsa050311.01587503
42GABAergic synapse_Homo sapiens_hsa047271.00553276
43Prion diseases_Homo sapiens_hsa050200.99291040
44Lysine degradation_Homo sapiens_hsa003100.98251502
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97528707
46Pyruvate metabolism_Homo sapiens_hsa006200.96039888
47Glycerolipid metabolism_Homo sapiens_hsa005610.94178771
48Tyrosine metabolism_Homo sapiens_hsa003500.91122759
49Butanoate metabolism_Homo sapiens_hsa006500.85432787
50Sphingolipid metabolism_Homo sapiens_hsa006000.85129904
51Steroid biosynthesis_Homo sapiens_hsa001000.84967970
52Biosynthesis of amino acids_Homo sapiens_hsa012300.82002905
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81931590
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81154957
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78706989
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76207443
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75822162
58Retinol metabolism_Homo sapiens_hsa008300.73049558
59Cocaine addiction_Homo sapiens_hsa050300.71573548
60beta-Alanine metabolism_Homo sapiens_hsa004100.69898864
61Glucagon signaling pathway_Homo sapiens_hsa049220.68914501
62Gastric acid secretion_Homo sapiens_hsa049710.67516355
63Starch and sucrose metabolism_Homo sapiens_hsa005000.66630341
64Nitrogen metabolism_Homo sapiens_hsa009100.66549082
65Circadian entrainment_Homo sapiens_hsa047130.66237723
66Dopaminergic synapse_Homo sapiens_hsa047280.64247179
67Chemical carcinogenesis_Homo sapiens_hsa052040.63820344
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.62859266
69Renin-angiotensin system_Homo sapiens_hsa046140.61938869
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61508317
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58174904
72Tryptophan metabolism_Homo sapiens_hsa003800.57932527
73Renin secretion_Homo sapiens_hsa049240.56424618
74Sulfur metabolism_Homo sapiens_hsa009200.54760293
75GnRH signaling pathway_Homo sapiens_hsa049120.54132899
76Morphine addiction_Homo sapiens_hsa050320.53707770
77Peroxisome_Homo sapiens_hsa041460.52678036
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52418845
79Caffeine metabolism_Homo sapiens_hsa002320.48107875
80Galactose metabolism_Homo sapiens_hsa000520.46652762
81Salivary secretion_Homo sapiens_hsa049700.46573799
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46319497
83Carbon metabolism_Homo sapiens_hsa012000.45953744
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44811226
85Cholinergic synapse_Homo sapiens_hsa047250.44286960
86Axon guidance_Homo sapiens_hsa043600.43075900
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43014918
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.42564116
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.42416085
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.41329689
91cAMP signaling pathway_Homo sapiens_hsa040240.39284809
92Ether lipid metabolism_Homo sapiens_hsa005650.38252016
93Estrogen signaling pathway_Homo sapiens_hsa049150.37993068
94Insulin resistance_Homo sapiens_hsa049310.37907063
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37737082
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37529037
97Pancreatic secretion_Homo sapiens_hsa049720.36588651
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36089787
99Staphylococcus aureus infection_Homo sapiens_hsa051500.35977257
100Calcium signaling pathway_Homo sapiens_hsa040200.35490647

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