C2ORF76

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.84341753
2proteasome assembly (GO:0043248)6.21192640
3ATP synthesis coupled proton transport (GO:0015986)5.78802697
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.78802697
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.48507474
6respiratory electron transport chain (GO:0022904)4.81410828
7establishment of protein localization to mitochondrial membrane (GO:0090151)4.81059718
8electron transport chain (GO:0022900)4.73085690
9protein complex biogenesis (GO:0070271)4.52532270
10mitochondrial respiratory chain complex assembly (GO:0033108)4.34373969
11chaperone-mediated protein transport (GO:0072321)4.33512078
12mitochondrial respiratory chain complex I assembly (GO:0032981)4.23322529
13NADH dehydrogenase complex assembly (GO:0010257)4.23322529
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.23322529
15protein neddylation (GO:0045116)4.11459294
16water-soluble vitamin biosynthetic process (GO:0042364)4.09413179
17organelle disassembly (GO:1903008)3.97252500
18nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.93402681
19exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.91611250
20response to pheromone (GO:0019236)3.86325092
21cullin deneddylation (GO:0010388)3.84805010
22DNA damage response, detection of DNA damage (GO:0042769)3.75829129
23respiratory chain complex IV assembly (GO:0008535)3.75811012
24protein deneddylation (GO:0000338)3.74816769
25sequestering of actin monomers (GO:0042989)3.73512337
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.66249739
27positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.64670222
28platelet dense granule organization (GO:0060155)3.64458135
29tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.58317181
30RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.58317181
31intraciliary transport (GO:0042073)3.54324140
32regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.52846202
33regulation of cellular amino acid metabolic process (GO:0006521)3.37935852
34cytochrome complex assembly (GO:0017004)3.36209651
35anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.36165680
36CENP-A containing nucleosome assembly (GO:0034080)3.31999213
37negative regulation of ligase activity (GO:0051352)3.30428726
38negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.30428726
39ATP biosynthetic process (GO:0006754)3.28100168
40hydrogen ion transmembrane transport (GO:1902600)3.25023482
41peptidyl-histidine modification (GO:0018202)3.24541603
42chromatin remodeling at centromere (GO:0031055)3.24255644
43C-terminal protein lipidation (GO:0006501)3.20685664
44ribonucleoprotein complex disassembly (GO:0032988)3.20112732
45inner mitochondrial membrane organization (GO:0007007)3.17802388
46purine nucleoside triphosphate biosynthetic process (GO:0009145)3.15227653
47regulation of mitochondrial translation (GO:0070129)3.14003745
48preassembly of GPI anchor in ER membrane (GO:0016254)3.12944725
49termination of RNA polymerase III transcription (GO:0006386)3.12676640
50transcription elongation from RNA polymerase III promoter (GO:0006385)3.12676640
51DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.09186635
52positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.08027617
53purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.07436693
54protein K11-linked ubiquitination (GO:0070979)3.07396317
55proton transport (GO:0015992)3.05421704
56DNA deamination (GO:0045006)3.04706780
57signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.02584573
58signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.02584573
59signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.02584573
60protein-cofactor linkage (GO:0018065)3.01551069
61rRNA modification (GO:0000154)2.99158312
62hydrogen transport (GO:0006818)2.99049239
63C-terminal protein amino acid modification (GO:0018410)2.98624094
64positive regulation of ligase activity (GO:0051351)2.98332540
65intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.98060962
66signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.98060962
67protein K6-linked ubiquitination (GO:0085020)2.97971474
68protein targeting to mitochondrion (GO:0006626)2.97493274
69intracellular protein transmembrane import (GO:0044743)2.95703226
70GPI anchor metabolic process (GO:0006505)2.95665307
71protein localization to mitochondrion (GO:0070585)2.95020509
72anterograde synaptic vesicle transport (GO:0048490)2.93618640
73establishment of protein localization to mitochondrion (GO:0072655)2.87926686
74mannosylation (GO:0097502)2.87895374
75signal transduction involved in cell cycle checkpoint (GO:0072395)2.86703207
76signal transduction involved in DNA integrity checkpoint (GO:0072401)2.85316239
77signal transduction involved in DNA damage checkpoint (GO:0072422)2.85316239
78protein localization to cilium (GO:0061512)2.80748380
79histone mRNA metabolic process (GO:0008334)2.80450744
80oxidative phosphorylation (GO:0006119)2.79754753
81positive regulation of prostaglandin secretion (GO:0032308)2.76157175
82regulation of meiosis I (GO:0060631)2.72949186
83GPI anchor biosynthetic process (GO:0006506)2.72311339
84signal peptide processing (GO:0006465)2.69749352
85regulation of mitotic spindle checkpoint (GO:1903504)2.69004483
86regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.69004483
87mitochondrial transport (GO:0006839)2.68501818
88regulation of ubiquitin-protein transferase activity (GO:0051438)2.63508549
89aldehyde catabolic process (GO:0046185)2.62976333
90transcription elongation from RNA polymerase I promoter (GO:0006362)2.62956414
91ribonucleoside triphosphate biosynthetic process (GO:0009201)2.61856906
92histone exchange (GO:0043486)2.60742489
937-methylguanosine mRNA capping (GO:0006370)2.60273702
94DNA double-strand break processing (GO:0000729)2.59718987
95regulation of ligase activity (GO:0051340)2.57343533
96regulation of cilium movement (GO:0003352)2.56827122
97negative regulation of protein ubiquitination (GO:0031397)2.53445041
98RNA capping (GO:0036260)2.53410062
997-methylguanosine RNA capping (GO:0009452)2.53410062
100pseudouridine synthesis (GO:0001522)2.53026937

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.71293661
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.42157009
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.78881841
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.52546158
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.15183065
6ELK1_19687146_ChIP-ChIP_HELA_Human3.07388601
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.77698678
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.68477121
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.63412181
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.62939817
11VDR_23849224_ChIP-Seq_CD4+_Human2.53467469
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.50141107
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.43252129
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.38455814
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28316134
16PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21545806
17ZNF274_21170338_ChIP-Seq_K562_Hela2.19523809
18* PADI4_21655091_ChIP-ChIP_MCF-7_Human2.13554316
19EWS_26573619_Chip-Seq_HEK293_Human2.05044273
20VDR_22108803_ChIP-Seq_LS180_Human2.04709186
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.04443347
22FOXP3_21729870_ChIP-Seq_TREG_Human1.99599253
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.94019511
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.93608329
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.86540690
26FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85315786
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83607470
28FUS_26573619_Chip-Seq_HEK293_Human1.83227392
29MYC_18940864_ChIP-ChIP_HL60_Human1.75507095
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73991323
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.71720912
32DCP1A_22483619_ChIP-Seq_HELA_Human1.69199600
33P300_19829295_ChIP-Seq_ESCs_Human1.64628621
34IGF1R_20145208_ChIP-Seq_DFB_Human1.63255970
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.62583278
36TAF15_26573619_Chip-Seq_HEK293_Human1.56219383
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50567496
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.49949225
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49835230
40GBX2_23144817_ChIP-Seq_PC3_Human1.48683199
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43770182
42ELK1_22589737_ChIP-Seq_MCF10A_Human1.39796699
43GABP_19822575_ChIP-Seq_HepG2_Human1.37647612
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.33480781
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32781771
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31986485
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30983747
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29002620
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.28256178
50ER_23166858_ChIP-Seq_MCF-7_Human1.26734559
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25625671
52IRF1_19129219_ChIP-ChIP_H3396_Human1.25323379
53RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23876252
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23765254
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23362223
56TP53_22573176_ChIP-Seq_HFKS_Human1.21978512
57TTF2_22483619_ChIP-Seq_HELA_Human1.21810541
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21782212
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.20488902
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19894478
61FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.18821944
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17821267
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.16014570
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13905788
65MYC_19030024_ChIP-ChIP_MESCs_Mouse1.13776364
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12502680
67FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11735634
68FOXA1_25329375_ChIP-Seq_VCAP_Human1.11735634
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10589026
70SOX2_19829295_ChIP-Seq_ESCs_Human1.09925515
71NANOG_19829295_ChIP-Seq_ESCs_Human1.09925515
72HTT_18923047_ChIP-ChIP_STHdh_Human1.08906666
73SALL4_22934838_ChIP-ChIP_CD34+_Human1.05437157
74HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05179747
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05061379
76MYC_18358816_ChIP-ChIP_MESCs_Mouse1.04026412
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02274868
78* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01636656
79CRX_20693478_ChIP-Seq_RETINA_Mouse1.00579195
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00553162
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00510843
82CBP_20019798_ChIP-Seq_JUKART_Human1.00510843
83AR_20517297_ChIP-Seq_VCAP_Human0.99872225
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98599446
85NANOG_18555785_Chip-Seq_ESCs_Mouse0.98047326
86HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97556976
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97229220
88* AR_25329375_ChIP-Seq_VCAP_Human0.95429841
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93887300
90STAT3_18555785_Chip-Seq_ESCs_Mouse0.93031437
91P53_22387025_ChIP-Seq_ESCs_Mouse0.92081448
92SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90797803
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89773408
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89231810
95FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89167544
96EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88391826
97* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88250508
98YY1_21170310_ChIP-Seq_MESCs_Mouse0.88125985
99NANOG_16153702_ChIP-ChIP_HESCs_Human0.87808916
100NELFA_20434984_ChIP-Seq_ESCs_Mouse0.87669607

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006072_abnormal_retinal_apoptosis2.82096088
2MP0008058_abnormal_DNA_repair2.80420593
3MP0003718_maternal_effect2.80057882
4MP0008877_abnormal_DNA_methylation2.78685113
5MP0006054_spinal_hemorrhage2.75738757
6MP0005084_abnormal_gallbladder_morpholo2.65032607
7MP0003806_abnormal_nucleotide_metabolis2.61060392
8MP0001529_abnormal_vocalization2.57236092
9MP0003011_delayed_dark_adaptation2.46093380
10MP0006036_abnormal_mitochondrial_physio2.38545187
11MP0000372_irregular_coat_pigmentation2.29954002
12MP0003186_abnormal_redox_activity2.22080265
13MP0003880_abnormal_central_pattern2.20671362
14MP0001984_abnormal_olfaction2.13032223
15MP0005379_endocrine/exocrine_gland_phen2.12595763
16MP0002837_dystrophic_cardiac_calcinosis2.11050732
17MP0003195_calcinosis1.99850313
18MP0005253_abnormal_eye_physiology1.92103525
19MP0006035_abnormal_mitochondrial_morpho1.87467573
20MP0009046_muscle_twitch1.84459771
21MP0002938_white_spotting1.81006748
22MP0005646_abnormal_pituitary_gland1.79862190
23MP0001764_abnormal_homeostasis1.78476484
24MP0003122_maternal_imprinting1.77882063
25MP0005408_hypopigmentation1.77150906
26MP0004147_increased_porphyrin_level1.75134387
27MP0008789_abnormal_olfactory_epithelium1.70179021
28MP0010386_abnormal_urinary_bladder1.69139464
29MP0009697_abnormal_copulation1.67854504
30MP0002638_abnormal_pupillary_reflex1.67261239
31MP0003121_genomic_imprinting1.61902965
32MP0000631_abnormal_neuroendocrine_gland1.60511220
33MP0005645_abnormal_hypothalamus_physiol1.59556880
34MP0002102_abnormal_ear_morphology1.59519744
35MP0005551_abnormal_eye_electrophysiolog1.54952712
36MP0006292_abnormal_olfactory_placode1.54525365
37MP0002254_reproductive_system_inflammat1.50264451
38MP0002909_abnormal_adrenal_gland1.45069458
39MP0002163_abnormal_gland_morphology1.44492009
40MP0002139_abnormal_hepatobiliary_system1.43498740
41MP0002090_abnormal_vision1.40662741
42MP0003693_abnormal_embryo_hatching1.39098477
43MP0010094_abnormal_chromosome_stability1.36470246
44MP0005410_abnormal_fertilization1.33903583
45MP0003786_premature_aging1.33799175
46MP0004142_abnormal_muscle_tone1.29676623
47MP0004957_abnormal_blastocyst_morpholog1.28075317
48MP0000358_abnormal_cell_content/1.26441953
49MP0001929_abnormal_gametogenesis1.24825316
50MP0002210_abnormal_sex_determination1.22195160
51MP0003136_yellow_coat_color1.21223397
52MP0008995_early_reproductive_senescence1.20487713
53MP0006276_abnormal_autonomic_nervous1.20097715
54MP0004133_heterotaxia1.14477146
55MP0002234_abnormal_pharynx_morphology1.14014895
56MP0002736_abnormal_nociception_after1.13988016
57MP0000653_abnormal_sex_gland1.12833209
58MP0002751_abnormal_autonomic_nervous1.12526061
59MP0005389_reproductive_system_phenotype1.12372586
60MP0001919_abnormal_reproductive_system1.10619456
61MP0002876_abnormal_thyroid_physiology1.08994954
62MP0008875_abnormal_xenobiotic_pharmacok1.08107069
63MP0005332_abnormal_amino_acid1.07317581
64MP0001905_abnormal_dopamine_level1.07259785
65MP0005248_abnormal_Harderian_gland1.05080256
66MP0005171_absent_coat_pigmentation1.04030173
67MP0005394_taste/olfaction_phenotype1.03851101
68MP0005499_abnormal_olfactory_system1.03851101
69MP0008872_abnormal_physiological_respon1.02893333
70MP0008932_abnormal_embryonic_tissue1.02774065
71MP0005174_abnormal_tail_pigmentation1.02310282
72MP0001486_abnormal_startle_reflex1.00478141
73MP0002272_abnormal_nervous_system0.97978514
74MP0001145_abnormal_male_reproductive0.96896154
75MP0001542_abnormal_bone_strength0.94081736
76MP0001293_anophthalmia0.92289713
77MP0005085_abnormal_gallbladder_physiolo0.91286298
78MP0001501_abnormal_sleep_pattern0.91201965
79MP0003077_abnormal_cell_cycle0.91185791
80MP0002295_abnormal_pulmonary_circulatio0.90913474
81MP0005266_abnormal_metabolism0.89398197
82MP0001188_hyperpigmentation0.86847538
83MP0001119_abnormal_female_reproductive0.85711089
84MP0000639_abnormal_adrenal_gland0.84239132
85MP0002233_abnormal_nose_morphology0.83407765
86MP0009764_decreased_sensitivity_to0.81664104
87MP0001756_abnormal_urination0.81398173
88MP0009745_abnormal_behavioral_response0.81159345
89MP0001324_abnormal_eye_pigmentation0.80910435
90MP0000647_abnormal_sebaceous_gland0.80566335
91MP0005075_abnormal_melanosome_morpholog0.80084381
92MP0002282_abnormal_trachea_morphology0.79180977
93MP0004043_abnormal_pH_regulation0.77541853
94MP0004215_abnormal_myocardial_fiber0.76744249
95MP0005395_other_phenotype0.76330420
96MP0003698_abnormal_male_reproductive0.75870036
97MP0002095_abnormal_skin_pigmentation0.74447619
98MP0010030_abnormal_orbit_morphology0.74356192
99MP0002928_abnormal_bile_duct0.74290111
100MP0005195_abnormal_posterior_eye0.73847208

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.14996483
2Progressive macrocephaly (HP:0004481)4.63573727
3Acute encephalopathy (HP:0006846)4.54129706
4Abnormal mitochondria in muscle tissue (HP:0008316)4.42172433
5Mitochondrial inheritance (HP:0001427)4.40895504
6Increased CSF lactate (HP:0002490)4.04739549
73-Methylglutaconic aciduria (HP:0003535)4.00515477
8Increased hepatocellular lipid droplets (HP:0006565)3.80963652
9Lipid accumulation in hepatocytes (HP:0006561)3.64116644
10Hepatocellular necrosis (HP:0001404)3.55771694
11Hepatic necrosis (HP:0002605)3.46957509
12Congenital, generalized hypertrichosis (HP:0004540)3.36964017
13Renal Fanconi syndrome (HP:0001994)3.31196711
14True hermaphroditism (HP:0010459)3.27216769
15Cerebral edema (HP:0002181)3.25991049
16Pancreatic cysts (HP:0001737)3.21341930
17Methylmalonic acidemia (HP:0002912)3.16546100
18Methylmalonic aciduria (HP:0012120)3.11024048
19Medial flaring of the eyebrow (HP:0010747)2.99036837
20Abnormality of midbrain morphology (HP:0002418)2.96912703
21Molar tooth sign on MRI (HP:0002419)2.96912703
22Pancreatic fibrosis (HP:0100732)2.95276064
23Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.89746184
24Decreased activity of mitochondrial respiratory chain (HP:0008972)2.89746184
25Type I transferrin isoform profile (HP:0003642)2.86785927
26Respiratory failure (HP:0002878)2.79655409
27Lactic acidosis (HP:0003128)2.68424675
28Increased serum lactate (HP:0002151)2.62424415
29Renal cortical cysts (HP:0000803)2.60407529
30Optic disc pallor (HP:0000543)2.51571549
31Aplasia/hypoplasia of the uterus (HP:0008684)2.50870631
32Congenital primary aphakia (HP:0007707)2.48508275
33Median cleft lip (HP:0000161)2.47213409
34Nephronophthisis (HP:0000090)2.41690442
35Exertional dyspnea (HP:0002875)2.38471514
36Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.36133606
37Abnormal protein N-linked glycosylation (HP:0012347)2.36133606
38Abnormal protein glycosylation (HP:0012346)2.36133606
39Abnormal glycosylation (HP:0012345)2.36133606
40Gait imbalance (HP:0002141)2.35500908
41Adrenal hypoplasia (HP:0000835)2.35436149
42Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.33652209
43Male pseudohermaphroditism (HP:0000037)2.30820901
44Nephrogenic diabetes insipidus (HP:0009806)2.28587846
45Lethargy (HP:0001254)2.25666448
46Exercise intolerance (HP:0003546)2.23389113
47Short tibia (HP:0005736)2.22575442
48Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.21188461
49Abnormality of renal resorption (HP:0011038)2.20716499
50Leukodystrophy (HP:0002415)2.20278916
51Increased intramyocellular lipid droplets (HP:0012240)2.19576872
52Abnormal sex determination (HP:0012244)2.19427105
53Sex reversal (HP:0012245)2.19427105
54Abnormality of the renal cortex (HP:0011035)2.19394185
55Abnormality of urine glucose concentration (HP:0011016)2.17993635
56Glycosuria (HP:0003076)2.17993635
57Congenital hepatic fibrosis (HP:0002612)2.16909931
58Generalized aminoaciduria (HP:0002909)2.15826493
59Hypothermia (HP:0002045)2.15286934
60Hypoglycemic coma (HP:0001325)2.14252051
61Hyperglycinemia (HP:0002154)2.12322911
62Aplasia/Hypoplasia of the tongue (HP:0010295)2.09528874
63Abnormality of vitamin B metabolism (HP:0004340)2.08339681
64Increased serum pyruvate (HP:0003542)2.07036759
65Abnormality of methionine metabolism (HP:0010901)2.06656289
66Genital tract atresia (HP:0001827)2.05726090
67Abnormality of the renal medulla (HP:0100957)2.03676842
68Aplasia/Hypoplasia of the tibia (HP:0005772)2.01856399
69Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00677814
70Degeneration of anterior horn cells (HP:0002398)1.99542985
71Abnormality of the anterior horn cell (HP:0006802)1.99542985
72Hypoplasia of the fovea (HP:0007750)1.98438570
73Aplasia/Hypoplasia of the fovea (HP:0008060)1.98438570
74Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.97960919
75CNS demyelination (HP:0007305)1.96063759
76Vaginal atresia (HP:0000148)1.96001716
77Intestinal atresia (HP:0011100)1.93517495
78Abnormality of the labia minora (HP:0012880)1.91244923
79Abnormality of aromatic amino acid family metabolism (HP:0004338)1.90512346
80Abnormality of the fovea (HP:0000493)1.88610682
81Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88165442
82Dicarboxylic aciduria (HP:0003215)1.88165442
83Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.84148414
84Postaxial hand polydactyly (HP:0001162)1.83719799
85X-linked dominant inheritance (HP:0001423)1.82871102
86Postaxial foot polydactyly (HP:0001830)1.82622295
87Abnormality of serum amino acid levels (HP:0003112)1.82132737
88Abnormal ciliary motility (HP:0012262)1.81746164
89Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81323617
90Abnormality of alanine metabolism (HP:0010916)1.81323617
91Hyperalaninemia (HP:0003348)1.81323617
92Attenuation of retinal blood vessels (HP:0007843)1.81110865
93Absent rod-and cone-mediated responses on ERG (HP:0007688)1.79197065
94Increased muscle lipid content (HP:0009058)1.77043133
95Abnormal respiratory motile cilium physiology (HP:0012261)1.75547788
96Sclerocornea (HP:0000647)1.75078438
97Reduced antithrombin III activity (HP:0001976)1.74983754
98Abnormal rod and cone electroretinograms (HP:0008323)1.72465587
99Rhinitis (HP:0012384)1.70551018
100Abnormality of glycolysis (HP:0004366)1.70148326

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K123.62858375
2MST43.61306015
3TRIM283.11401605
4EIF2AK32.80232304
5MAP4K22.65288608
6WNK32.36331583
7ZAK2.32980338
8EIF2AK12.24716415
9INSRR2.18317227
10FRK2.16748938
11PBK2.16346784
12BUB12.01797324
13BMPR1B2.00960733
14STK161.92362495
15VRK21.92186954
16NEK11.89164314
17NUAK11.85788852
18FER1.84038782
19VRK11.67057184
20SRPK11.64153947
21ACVR1B1.62525028
22BCR1.61313145
23PLK31.60152134
24CSNK1G31.56909748
25ERBB31.53270023
26CSNK1G21.52124851
27CSNK1G11.40420650
28MAP3K41.39387847
29GRK11.35428449
30ADRBK21.35227171
31PLK21.33121775
32CSNK1A1L1.31454945
33PLK41.22197760
34FES1.22148568
35TNIK1.15486016
36BCKDK1.14606109
37MAP2K71.13593528
38TAOK31.04953518
39STK38L1.04276567
40BRSK21.00892254
41MYLK0.94540063
42PNCK0.94185036
43CCNB10.93908122
44TLK10.91791972
45MKNK10.90675261
46GRK70.90652124
47DYRK30.90579155
48EPHA30.90238391
49PRKCE0.90179965
50TSSK60.88331843
51MKNK20.80420222
52MAPK130.80251377
53DYRK20.79858158
54WEE10.79626148
55PDK20.78291522
56PAK30.78276136
57BMPR20.77068911
58PLK10.74182887
59NME10.71838607
60TTK0.71399215
61CASK0.68103601
62NME20.66810670
63EIF2AK20.65218410
64AKT30.58856670
65CDC70.58065807
66PIM20.57272540
67LIMK10.57253419
68STK240.55840650
69PRKCI0.54737767
70TGFBR10.54058786
71CDK80.53673560
72PINK10.53667301
73DAPK10.53182916
74RPS6KA50.51931496
75STK30.48764482
76FLT30.48073347
77BRAF0.47812118
78MAP3K50.45578963
79CSNK1A10.45052672
80CSNK2A10.42688824
81GRK50.42599604
82IRAK20.42508607
83ARAF0.42277047
84PHKG20.40174155
85PHKG10.40174155
86OXSR10.39209201
87IKBKB0.35636383
88TXK0.35348224
89RPS6KA40.34546976
90ILK0.33896822
91ATR0.33352775
92ATM0.32137459
93BRSK10.31949531
94TESK10.31375403
95CSNK2A20.30297273
96IRAK10.30218511
97SIK30.29913512
98STK390.28711895
99CAMK2A0.28514925
100MINK10.27989921

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.61370693
2Protein export_Homo sapiens_hsa030604.41237389
3Proteasome_Homo sapiens_hsa030504.17230967
4Parkinsons disease_Homo sapiens_hsa050123.90856570
5Huntingtons disease_Homo sapiens_hsa050162.67172599
6Alzheimers disease_Homo sapiens_hsa050102.54279559
7Ribosome_Homo sapiens_hsa030102.50076680
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.38155931
9RNA polymerase_Homo sapiens_hsa030202.37923757
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.25489926
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.13453056
12Homologous recombination_Homo sapiens_hsa034402.06985241
13Propanoate metabolism_Homo sapiens_hsa006402.04757256
14Mismatch repair_Homo sapiens_hsa034302.02191060
15Basal transcription factors_Homo sapiens_hsa030222.00203233
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.99603541
17Folate biosynthesis_Homo sapiens_hsa007901.74403107
18RNA degradation_Homo sapiens_hsa030181.70294704
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69983831
20Sulfur metabolism_Homo sapiens_hsa009201.66678718
21Collecting duct acid secretion_Homo sapiens_hsa049661.52643162
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48118859
23Nucleotide excision repair_Homo sapiens_hsa034201.43215495
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40276103
25Fanconi anemia pathway_Homo sapiens_hsa034601.35219520
26Non-homologous end-joining_Homo sapiens_hsa034501.34262511
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33177829
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.26187665
29Cardiac muscle contraction_Homo sapiens_hsa042601.24559290
30Fatty acid elongation_Homo sapiens_hsa000621.22377711
31RNA transport_Homo sapiens_hsa030131.21727914
32Steroid biosynthesis_Homo sapiens_hsa001001.21647226
33Pyrimidine metabolism_Homo sapiens_hsa002401.18041352
34Spliceosome_Homo sapiens_hsa030401.16002784
35One carbon pool by folate_Homo sapiens_hsa006701.07494384
36DNA replication_Homo sapiens_hsa030301.03660822
37Glutathione metabolism_Homo sapiens_hsa004801.01146194
38Butanoate metabolism_Homo sapiens_hsa006501.00842404
39Regulation of autophagy_Homo sapiens_hsa041400.98494546
40Purine metabolism_Homo sapiens_hsa002300.98001916
41Phototransduction_Homo sapiens_hsa047440.95590336
42Peroxisome_Homo sapiens_hsa041460.92397860
43Base excision repair_Homo sapiens_hsa034100.88809684
44Caffeine metabolism_Homo sapiens_hsa002320.88703529
45Tryptophan metabolism_Homo sapiens_hsa003800.85483054
46Pyruvate metabolism_Homo sapiens_hsa006200.85290590
47Selenocompound metabolism_Homo sapiens_hsa004500.84739617
48Metabolic pathways_Homo sapiens_hsa011000.81634898
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.80922066
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79105450
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78883871
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78687500
53Chemical carcinogenesis_Homo sapiens_hsa052040.78051586
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.77592477
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77345811
56Vitamin B6 metabolism_Homo sapiens_hsa007500.76264755
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74696261
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72183817
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70956245
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67979660
61Rheumatoid arthritis_Homo sapiens_hsa053230.67651822
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64731244
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63089061
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62411960
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60442772
66Oocyte meiosis_Homo sapiens_hsa041140.58675218
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.53957525
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53863296
69Vibrio cholerae infection_Homo sapiens_hsa051100.53369759
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52349416
71Nitrogen metabolism_Homo sapiens_hsa009100.52041472
72Cell cycle_Homo sapiens_hsa041100.49625454
73Circadian rhythm_Homo sapiens_hsa047100.48653464
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45555428
75N-Glycan biosynthesis_Homo sapiens_hsa005100.45254190
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44695868
77Nicotine addiction_Homo sapiens_hsa050330.44618724
78p53 signaling pathway_Homo sapiens_hsa041150.41627992
79Sulfur relay system_Homo sapiens_hsa041220.41504469
80Legionellosis_Homo sapiens_hsa051340.41266273
81Olfactory transduction_Homo sapiens_hsa047400.37542785
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35937471
83Retinol metabolism_Homo sapiens_hsa008300.35540804
84Fatty acid degradation_Homo sapiens_hsa000710.33757080
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33119348
86Asthma_Homo sapiens_hsa053100.32708250
87GABAergic synapse_Homo sapiens_hsa047270.32519533
88Synaptic vesicle cycle_Homo sapiens_hsa047210.31621809
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.29336818
90Mineral absorption_Homo sapiens_hsa049780.29024088
91Linoleic acid metabolism_Homo sapiens_hsa005910.28644048
92Carbon metabolism_Homo sapiens_hsa012000.28607531
93beta-Alanine metabolism_Homo sapiens_hsa004100.26888780
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24911777
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23735548
96Fatty acid metabolism_Homo sapiens_hsa012120.23640717
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23525573
98Ether lipid metabolism_Homo sapiens_hsa005650.23408196
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22405977
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20962256

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