C2ORF74

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.62918859
2ATP synthesis coupled proton transport (GO:0015986)5.18551935
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.18551935
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.18147663
5protein complex biogenesis (GO:0070271)4.95538245
6respiratory electron transport chain (GO:0022904)4.58890313
7electron transport chain (GO:0022900)4.56276584
8mitochondrial respiratory chain complex assembly (GO:0033108)4.53184036
9respiratory chain complex IV assembly (GO:0008535)4.45005334
10mitochondrial respiratory chain complex I assembly (GO:0032981)4.29025770
11NADH dehydrogenase complex assembly (GO:0010257)4.29025770
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.29025770
13water-soluble vitamin biosynthetic process (GO:0042364)4.18278911
14cytochrome complex assembly (GO:0017004)4.13277198
15establishment of protein localization to mitochondrial membrane (GO:0090151)3.94296537
16epithelial cilium movement (GO:0003351)3.88877776
17behavioral response to nicotine (GO:0035095)3.77619487
18chaperone-mediated protein transport (GO:0072321)3.70952356
19protein neddylation (GO:0045116)3.57783022
20hydrogen ion transmembrane transport (GO:1902600)3.55754082
21nonmotile primary cilium assembly (GO:0035058)3.54756690
22regulation of glucokinase activity (GO:0033131)3.52483666
23regulation of hexokinase activity (GO:1903299)3.52483666
24regulation of cilium movement (GO:0003352)3.52349041
25response to pheromone (GO:0019236)3.45764883
26platelet dense granule organization (GO:0060155)3.45353576
27cellular ketone body metabolic process (GO:0046950)3.40929702
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.32741590
29axoneme assembly (GO:0035082)3.32557326
30proton transport (GO:0015992)3.31593414
31protein polyglutamylation (GO:0018095)3.28601314
32DNA deamination (GO:0045006)3.28233685
33hydrogen transport (GO:0006818)3.27427513
34intraciliary transport (GO:0042073)3.15584906
35cilium movement (GO:0003341)3.14595976
36ATP biosynthetic process (GO:0006754)3.10408022
37ketone body metabolic process (GO:1902224)3.04948790
38purine nucleoside triphosphate biosynthetic process (GO:0009145)2.99841552
39purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.96195567
40mannosylation (GO:0097502)2.93004837
41regulation of mitochondrial translation (GO:0070129)2.90287411
42proteasome assembly (GO:0043248)2.89112621
43termination of RNA polymerase III transcription (GO:0006386)2.81173479
44transcription elongation from RNA polymerase III promoter (GO:0006385)2.81173479
45protein-cofactor linkage (GO:0018065)2.75493413
46aldehyde catabolic process (GO:0046185)2.73633594
47preassembly of GPI anchor in ER membrane (GO:0016254)2.72413007
48nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.71722454
49detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.69365738
50cilium morphogenesis (GO:0060271)2.63143794
51cilium organization (GO:0044782)2.62754305
52protein localization to cilium (GO:0061512)2.59149672
53intracellular protein transmembrane import (GO:0044743)2.58012735
54dopamine transport (GO:0015872)2.55604481
55negative regulation of appetite (GO:0032099)2.55330712
56negative regulation of response to food (GO:0032096)2.55330712
57C-terminal protein lipidation (GO:0006501)2.54105812
58cilium assembly (GO:0042384)2.53443771
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.52965440
60RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.52965440
61axonemal dynein complex assembly (GO:0070286)2.52739321
62regulation of microtubule-based movement (GO:0060632)2.52621994
63GTP biosynthetic process (GO:0006183)2.51189460
64exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.50389279
65glycerophospholipid catabolic process (GO:0046475)2.49127404
66indolalkylamine metabolic process (GO:0006586)2.48127203
67ribonucleoside triphosphate biosynthetic process (GO:0009201)2.47513094
68signal peptide processing (GO:0006465)2.46529640
69energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.45714984
70ATP hydrolysis coupled proton transport (GO:0015991)2.45714984
71GPI anchor metabolic process (GO:0006505)2.44869809
72organelle disassembly (GO:1903008)2.44267637
73L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.41554635
74retinal cone cell development (GO:0046549)2.40651820
75C-terminal protein amino acid modification (GO:0018410)2.38123712
76branched-chain amino acid catabolic process (GO:0009083)2.37530018
77sperm motility (GO:0030317)2.37370791
78inner mitochondrial membrane organization (GO:0007007)2.37291592
79anterograde synaptic vesicle transport (GO:0048490)2.36403704
80establishment of protein localization to mitochondrion (GO:0072655)2.36119757
81cullin deneddylation (GO:0010388)2.35918942
82GPI anchor biosynthetic process (GO:0006506)2.32903410
83protein targeting to mitochondrion (GO:0006626)2.32044774
84protein deneddylation (GO:0000338)2.31758807
85sequestering of actin monomers (GO:0042989)2.31106147
86protein K6-linked ubiquitination (GO:0085020)2.30546123
87photoreceptor cell maintenance (GO:0045494)2.29255127
88nucleoside triphosphate biosynthetic process (GO:0009142)2.28270283
89spinal cord motor neuron differentiation (GO:0021522)2.28002861
90ubiquinone biosynthetic process (GO:0006744)2.27671654
91pseudouridine synthesis (GO:0001522)2.26244425
92protein localization to mitochondrion (GO:0070585)2.24899638
93indole-containing compound catabolic process (GO:0042436)2.23229386
94indolalkylamine catabolic process (GO:0046218)2.23229386
95tryptophan catabolic process (GO:0006569)2.23229386
96pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.23009005
97aromatic amino acid family catabolic process (GO:0009074)2.22493864
98retinal ganglion cell axon guidance (GO:0031290)2.22451782
99peptidyl-histidine modification (GO:0018202)2.22169548
100ubiquinone metabolic process (GO:0006743)2.22060388

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.24834784
2ZNF274_21170338_ChIP-Seq_K562_Hela3.08097275
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.06140763
4HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.75112748
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.73747818
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.48446077
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.45880643
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.36628580
9GBX2_23144817_ChIP-Seq_PC3_Human2.35377743
10VDR_22108803_ChIP-Seq_LS180_Human2.29949687
11FUS_26573619_Chip-Seq_HEK293_Human2.20587720
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.19867451
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19062403
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14887506
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09949704
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.08713492
17EZH2_22144423_ChIP-Seq_EOC_Human2.08630253
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.07099351
19TAF15_26573619_Chip-Seq_HEK293_Human2.05111016
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95614753
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93582209
22EWS_26573619_Chip-Seq_HEK293_Human1.92945094
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92061393
24P300_19829295_ChIP-Seq_ESCs_Human1.89254445
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83710722
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80502911
27IGF1R_20145208_ChIP-Seq_DFB_Human1.80120808
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.74176262
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70718536
30ELK1_19687146_ChIP-ChIP_HELA_Human1.70227783
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.66144368
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58466592
33VDR_23849224_ChIP-Seq_CD4+_Human1.57825945
34MYC_18940864_ChIP-ChIP_HL60_Human1.56398422
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.52086353
36TP53_22573176_ChIP-Seq_HFKS_Human1.47071026
37ER_23166858_ChIP-Seq_MCF-7_Human1.42742012
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42398878
39REST_21632747_ChIP-Seq_MESCs_Mouse1.39578861
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39366297
41HTT_18923047_ChIP-ChIP_STHdh_Human1.37935273
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36824189
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36630521
44CBP_20019798_ChIP-Seq_JUKART_Human1.36630521
45BCAT_22108803_ChIP-Seq_LS180_Human1.33295017
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.32854766
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32239817
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30245494
49RNF2_27304074_Chip-Seq_NSC_Mouse1.29964724
50SMAD4_21799915_ChIP-Seq_A2780_Human1.27200021
51AR_25329375_ChIP-Seq_VCAP_Human1.27171473
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26570381
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25822742
54GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25184095
55NANOG_19829295_ChIP-Seq_ESCs_Human1.24786233
56SOX2_19829295_ChIP-Seq_ESCs_Human1.24786233
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24110975
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.23904180
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23904180
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23567123
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19998404
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19928155
63REST_18959480_ChIP-ChIP_MESCs_Mouse1.19536116
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.18951750
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.18668701
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17320500
67EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14446603
68FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13752450
69AR_20517297_ChIP-Seq_VCAP_Human1.13523149
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11216503
71ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10438163
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10394651
73RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10150097
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.10032846
75NCOR_22424771_ChIP-Seq_293T_Human1.09891425
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.09513222
77FOXP3_21729870_ChIP-Seq_TREG_Human1.09017866
78TCF4_22108803_ChIP-Seq_LS180_Human1.08998152
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.08885944
80FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06904983
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04106811
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04106811
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03940986
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02354549
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01757981
86IRF1_19129219_ChIP-ChIP_H3396_Human1.01593883
87POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01515431
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00950465
89GATA3_21878914_ChIP-Seq_MCF-7_Human1.00594150
90RUNX2_22187159_ChIP-Seq_PCA_Human1.00074324
91STAT3_23295773_ChIP-Seq_U87_Human0.99046320
92P53_22387025_ChIP-Seq_ESCs_Mouse0.98869380
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98447074
94TCF4_23295773_ChIP-Seq_U87_Human0.98264218
95CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97336950
96TAL1_26923725_Chip-Seq_HPCs_Mouse0.96137694
97PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95392399
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95365833
99SALL1_21062744_ChIP-ChIP_HESCs_Human0.94103469
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.92700908

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation2.81211030
2MP0003787_abnormal_imprinting2.77876751
3MP0003880_abnormal_central_pattern2.51332881
4MP0002837_dystrophic_cardiac_calcinosis2.47891465
5MP0001984_abnormal_olfaction2.46796727
6MP0002102_abnormal_ear_morphology2.36487927
7MP0005084_abnormal_gallbladder_morpholo2.35092116
8MP0006072_abnormal_retinal_apoptosis2.15546970
9MP0003195_calcinosis2.14541478
10MP0005551_abnormal_eye_electrophysiolog2.12628920
11MP0009046_muscle_twitch2.10093616
12MP0003122_maternal_imprinting2.07198944
13MP0002272_abnormal_nervous_system2.01915263
14MP0002938_white_spotting2.01403503
15MP0003011_delayed_dark_adaptation1.99684163
16MP0001529_abnormal_vocalization1.99603680
17MP0009745_abnormal_behavioral_response1.96728195
18MP0005646_abnormal_pituitary_gland1.95529275
19MP0010386_abnormal_urinary_bladder1.90414215
20MP0006292_abnormal_olfactory_placode1.88063084
21MP0002638_abnormal_pupillary_reflex1.85661676
22MP0004147_increased_porphyrin_level1.83702691
23MP0005645_abnormal_hypothalamus_physiol1.76679020
24MP0002653_abnormal_ependyma_morphology1.75656954
25MP0001968_abnormal_touch/_nociception1.70986996
26MP0001485_abnormal_pinna_reflex1.69477897
27MP0003283_abnormal_digestive_organ1.68388131
28MP0005379_endocrine/exocrine_gland_phen1.67985100
29MP0004142_abnormal_muscle_tone1.65564990
30MP0006276_abnormal_autonomic_nervous1.63198802
31MP0001905_abnormal_dopamine_level1.62828670
32MP0002064_seizures1.60832513
33MP0002909_abnormal_adrenal_gland1.59768433
34MP0005253_abnormal_eye_physiology1.56885460
35MP0000372_irregular_coat_pigmentation1.55869957
36MP0001486_abnormal_startle_reflex1.55521644
37MP0005423_abnormal_somatic_nervous1.52805305
38MP0004133_heterotaxia1.52084140
39MP0003121_genomic_imprinting1.48832074
40MP0002876_abnormal_thyroid_physiology1.45115228
41MP0003136_yellow_coat_color1.44614309
42MP0002572_abnormal_emotion/affect_behav1.44046533
43MP0002163_abnormal_gland_morphology1.43898568
44MP0008875_abnormal_xenobiotic_pharmacok1.43432017
45MP0002736_abnormal_nociception_after1.40313470
46MP0004885_abnormal_endolymph1.35164518
47MP0000631_abnormal_neuroendocrine_gland1.31275065
48MP0003806_abnormal_nucleotide_metabolis1.30917427
49MP0006036_abnormal_mitochondrial_physio1.30352649
50MP0005410_abnormal_fertilization1.29896696
51MP0002557_abnormal_social/conspecific_i1.29809203
52MP0008872_abnormal_physiological_respon1.29472060
53MP0003186_abnormal_redox_activity1.28302954
54MP0003635_abnormal_synaptic_transmissio1.26894695
55MP0002734_abnormal_mechanical_nocicepti1.26628994
56MP0001970_abnormal_pain_threshold1.25559081
57MP0002160_abnormal_reproductive_system1.24041317
58MP0008789_abnormal_olfactory_epithelium1.23451790
59MP0000569_abnormal_digit_pigmentation1.20337318
60MP0002067_abnormal_sensory_capabilities1.17861792
61MP0002063_abnormal_learning/memory/cond1.16779130
62MP0004270_analgesia1.13667816
63MP0002733_abnormal_thermal_nociception1.13045309
64MP0005386_behavior/neurological_phenoty1.11639434
65MP0004924_abnormal_behavior1.11639434
66MP0002090_abnormal_vision1.09489778
67MP0009780_abnormal_chondrocyte_physiolo1.05094878
68MP0002229_neurodegeneration1.02750664
69MP0005389_reproductive_system_phenotype1.01542089
70MP0001501_abnormal_sleep_pattern1.00668512
71MP0001188_hyperpigmentation0.99906530
72MP0004742_abnormal_vestibular_system0.99264665
73MP0004859_abnormal_synaptic_plasticity0.99201023
74MP0002693_abnormal_pancreas_physiology0.97918145
75MP0002184_abnormal_innervation0.97827990
76MP0001944_abnormal_pancreas_morphology0.97475102
77MP0009379_abnormal_foot_pigmentation0.96902603
78MP0005195_abnormal_posterior_eye0.96545062
79MP0005332_abnormal_amino_acid0.95841455
80MP0004215_abnormal_myocardial_fiber0.95030845
81MP0008058_abnormal_DNA_repair0.94722160
82MP0001440_abnormal_grooming_behavior0.91609653
83MP0000778_abnormal_nervous_system0.90555784
84MP0005499_abnormal_olfactory_system0.89688633
85MP0005394_taste/olfaction_phenotype0.89688633
86MP0002752_abnormal_somatic_nervous0.89584472
87MP0002277_abnormal_respiratory_mucosa0.87464150
88MP0005174_abnormal_tail_pigmentation0.86188138
89MP0000955_abnormal_spinal_cord0.86019528
90MP0003698_abnormal_male_reproductive0.85130307
91MP0003718_maternal_effect0.84861176
92MP0005075_abnormal_melanosome_morpholog0.84699108
93MP0004019_abnormal_vitamin_homeostasis0.84097308
94MP0002928_abnormal_bile_duct0.83544174
95MP0001963_abnormal_hearing_physiology0.83382448
96MP0001929_abnormal_gametogenesis0.82593216
97MP0001919_abnormal_reproductive_system0.81136525
98MP0003137_abnormal_impulse_conducting0.78747884
99MP0000026_abnormal_inner_ear0.77805952
100MP0001293_anophthalmia0.77213962

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.46729095
2Mitochondrial inheritance (HP:0001427)4.20361798
3Abnormal mitochondria in muscle tissue (HP:0008316)4.06553073
4Progressive macrocephaly (HP:0004481)3.94081462
5Increased CSF lactate (HP:0002490)3.81152607
6Acute encephalopathy (HP:0006846)3.76100944
7Increased hepatocellular lipid droplets (HP:0006565)3.75381987
8Abnormality of midbrain morphology (HP:0002418)3.64720013
9Molar tooth sign on MRI (HP:0002419)3.64720013
10Medial flaring of the eyebrow (HP:0010747)3.58116342
11Lipid accumulation in hepatocytes (HP:0006561)3.49126817
12Hepatocellular necrosis (HP:0001404)3.49002446
13Pancreatic cysts (HP:0001737)3.47613316
14Pancreatic fibrosis (HP:0100732)3.46149445
15Hepatic necrosis (HP:0002605)3.41924651
16Nephronophthisis (HP:0000090)3.32204085
17Renal Fanconi syndrome (HP:0001994)3.31748216
18True hermaphroditism (HP:0010459)3.28790120
193-Methylglutaconic aciduria (HP:0003535)3.28787842
20Methylmalonic acidemia (HP:0002912)3.22142664
21Gait imbalance (HP:0002141)2.92124094
22Cerebral edema (HP:0002181)2.82177500
23Congenital primary aphakia (HP:0007707)2.81974897
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.69369112
25Decreased activity of mitochondrial respiratory chain (HP:0008972)2.69369112
26Methylmalonic aciduria (HP:0012120)2.68645685
27Increased intramyocellular lipid droplets (HP:0012240)2.67916519
28Abnormality of the renal medulla (HP:0100957)2.66129706
29Hypothermia (HP:0002045)2.59590532
30Nephrogenic diabetes insipidus (HP:0009806)2.58632796
31Abnormality of renal resorption (HP:0011038)2.57262334
32Hyperinsulinemic hypoglycemia (HP:0000825)2.54726327
33Myokymia (HP:0002411)2.49539530
34Exertional dyspnea (HP:0002875)2.49293304
35Genital tract atresia (HP:0001827)2.43018368
36Abnormality of the renal cortex (HP:0011035)2.42751752
37Abnormality of urine glucose concentration (HP:0011016)2.40638269
38Glycosuria (HP:0003076)2.40638269
39Optic disc pallor (HP:0000543)2.40102302
40Vaginal atresia (HP:0000148)2.38117865
41Congenital stationary night blindness (HP:0007642)2.36879316
42Lactic acidosis (HP:0003128)2.34505674
43Increased serum lactate (HP:0002151)2.27528982
44Respiratory failure (HP:0002878)2.27421016
45Renal cortical cysts (HP:0000803)2.24205692
46Type II lissencephaly (HP:0007260)2.22710835
47Congenital, generalized hypertrichosis (HP:0004540)2.20958567
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.19216372
49Increased muscle lipid content (HP:0009058)2.18531014
50Hyperglycinemia (HP:0002154)2.17563175
51Abnormal ciliary motility (HP:0012262)2.14934006
52Cystic liver disease (HP:0006706)2.13195110
53Abnormal respiratory epithelium morphology (HP:0012253)2.13027155
54Abnormal respiratory motile cilium morphology (HP:0005938)2.13027155
55Abnormality of the labia minora (HP:0012880)2.12547433
56Sclerocornea (HP:0000647)2.09919896
57Abnormal drinking behavior (HP:0030082)2.06933224
58Polydipsia (HP:0001959)2.06933224
59Hypoglycemic coma (HP:0001325)2.06759786
60Absent/shortened dynein arms (HP:0200106)2.06522212
61Dynein arm defect of respiratory motile cilia (HP:0012255)2.06522212
62Leukodystrophy (HP:0002415)2.06417707
63Polyphagia (HP:0002591)2.06262760
64Hyperphosphaturia (HP:0003109)2.05403177
65Intestinal atresia (HP:0011100)2.05122220
66Lethargy (HP:0001254)2.04626505
67Ketoacidosis (HP:0001993)2.04477626
68Limb dystonia (HP:0002451)2.03464742
69Abnormal respiratory motile cilium physiology (HP:0012261)2.02923532
70Ketosis (HP:0001946)1.99327256
71Congenital hepatic fibrosis (HP:0002612)1.97981104
72Abnormality of vitamin B metabolism (HP:0004340)1.97651389
73Large for gestational age (HP:0001520)1.96548393
74Progressive cerebellar ataxia (HP:0002073)1.96106236
75Male pseudohermaphroditism (HP:0000037)1.95587793
76Febrile seizures (HP:0002373)1.95164002
77Abolished electroretinogram (ERG) (HP:0000550)1.93578178
78Focal motor seizures (HP:0011153)1.93184950
79Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92617693
80Abnormality of alanine metabolism (HP:0010916)1.92617693
81Hyperalaninemia (HP:0003348)1.92617693
82Short tibia (HP:0005736)1.92556562
83Aplasia/Hypoplasia of the tibia (HP:0005772)1.89745929
84Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.87711936
85Dialeptic seizures (HP:0011146)1.87710973
86Optic nerve hypoplasia (HP:0000609)1.86883567
87Hemiparesis (HP:0001269)1.85747092
88Exercise intolerance (HP:0003546)1.85541337
89Hypomagnesemia (HP:0002917)1.84915069
90CNS demyelination (HP:0007305)1.84735656
91Tubular atrophy (HP:0000092)1.82666303
92Chronic hepatic failure (HP:0100626)1.82184600
93Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.82177236
94Abnormality of dicarboxylic acid metabolism (HP:0010995)1.81522860
95Dicarboxylic aciduria (HP:0003215)1.81522860
96Abnormal rod and cone electroretinograms (HP:0008323)1.81115721
97Generalized aminoaciduria (HP:0002909)1.80930433
98Aplasia/hypoplasia of the uterus (HP:0008684)1.80834871
99Anencephaly (HP:0002323)1.79520645
100Type I transferrin isoform profile (HP:0003642)1.78531609

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.47104038
2BMPR1B3.21109966
3FRK3.15123698
4ADRBK22.59647690
5WNK32.59025159
6STK162.45175825
7PINK12.41405050
8GRK12.20501347
9BCKDK2.13248849
10VRK22.10447014
11ZAK2.09786534
12PNCK2.04345611
13TNIK1.86759246
14NUAK11.83511467
15INSRR1.82721100
16MAP3K41.71464448
17CASK1.61140722
18MAPK131.60250538
19DYRK21.54721927
20MAP3K121.52285612
21DAPK21.50821766
22VRK11.48144124
23MAP2K71.46367057
24LIMK11.41275258
25PRKCG1.36605985
26ACVR1B1.33373638
27WNK41.30607568
28NTRK31.28696281
29PHKG21.27854445
30PHKG11.27854445
31PAK31.27191432
32PLK21.24514683
33MARK11.24316339
34EPHA41.18967157
35MST41.18594278
36TLK11.17877342
37PLK31.08137802
38TXK1.06842451
39PASK1.03879606
40CSNK1G20.99374972
41OXSR10.95989289
42FGFR20.93533944
43PRKCE0.93478619
44CSNK1G10.93152265
45CSNK1G30.89670784
46NME10.88561560
47NTRK20.85044667
48BUB10.83180141
49TRIM280.82956851
50TGFBR10.80991046
51TAOK30.76717060
52CAMKK20.75941453
53MKNK20.74731701
54CAMK2A0.73335494
55UHMK10.72606487
56MINK10.68729096
57STK390.67538365
58EIF2AK30.67480107
59PDK20.66083289
60ADRBK10.65212045
61ERBB30.62178173
62GRK50.61385497
63BCR0.61282161
64CAMK10.60293249
65STK38L0.59655789
66RPS6KA50.57687230
67PRKACA0.57271625
68PLK10.56347269
69SRPK10.56096647
70PLK40.55719196
71CDC70.55317787
72DAPK10.55150777
73NEK10.52264622
74CDK190.51618363
75PRKCQ0.51559978
76OBSCN0.51013188
77CAMK2D0.49552683
78CDK80.49089984
79CSNK1A10.49077215
80PRKG10.48017301
81MAPK150.47465599
82PIK3CA0.47237676
83GRK70.46792302
84MUSK0.46255482
85NLK0.46250684
86MAP2K60.45903422
87CCNB10.45141330
88PKN10.45079517
89KIT0.44040316
90PRKCA0.43567330
91MKNK10.42971003
92TIE10.42030705
93WEE10.41830787
94BRSK20.41555285
95CSNK1A1L0.40371799
96PRKACB0.38701470
97PRKCI0.38429261
98ABL20.37726186
99CSNK2A20.37717632
100CDK30.36191019

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.48571826
2Parkinsons disease_Homo sapiens_hsa050123.57757761
3Protein export_Homo sapiens_hsa030603.26661435
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.65297947
5Proteasome_Homo sapiens_hsa030502.56573804
6Huntingtons disease_Homo sapiens_hsa050162.48247754
7Alzheimers disease_Homo sapiens_hsa050102.43696831
8Ribosome_Homo sapiens_hsa030102.41543483
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.41323120
10Cardiac muscle contraction_Homo sapiens_hsa042602.29480055
11RNA polymerase_Homo sapiens_hsa030202.08362362
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06928013
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.01343611
14Butanoate metabolism_Homo sapiens_hsa006502.00068245
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.83091736
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70595105
17Nicotine addiction_Homo sapiens_hsa050331.68080284
18Folate biosynthesis_Homo sapiens_hsa007901.63958341
19Collecting duct acid secretion_Homo sapiens_hsa049661.59832145
20Phototransduction_Homo sapiens_hsa047441.58686231
21Propanoate metabolism_Homo sapiens_hsa006401.52542435
22Tryptophan metabolism_Homo sapiens_hsa003801.40320736
23Homologous recombination_Homo sapiens_hsa034401.39749679
24Nitrogen metabolism_Homo sapiens_hsa009101.39550597
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33193208
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26665513
27Basal transcription factors_Homo sapiens_hsa030221.26178978
28Peroxisome_Homo sapiens_hsa041461.21276790
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.16070732
30Fatty acid elongation_Homo sapiens_hsa000621.16029896
31Selenocompound metabolism_Homo sapiens_hsa004501.16015167
32Insulin secretion_Homo sapiens_hsa049111.12149055
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11340492
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07137093
35Regulation of autophagy_Homo sapiens_hsa041401.03705624
36GABAergic synapse_Homo sapiens_hsa047271.02614830
37Morphine addiction_Homo sapiens_hsa050320.98264169
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97821711
39Linoleic acid metabolism_Homo sapiens_hsa005910.96584836
40Synaptic vesicle cycle_Homo sapiens_hsa047210.96493119
41Sulfur metabolism_Homo sapiens_hsa009200.95311721
42Purine metabolism_Homo sapiens_hsa002300.93620425
43Caffeine metabolism_Homo sapiens_hsa002320.92562172
44RNA degradation_Homo sapiens_hsa030180.91489100
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89224978
46beta-Alanine metabolism_Homo sapiens_hsa004100.87249076
47Chemical carcinogenesis_Homo sapiens_hsa052040.86870832
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86184692
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85010871
50Metabolic pathways_Homo sapiens_hsa011000.84936561
51Steroid biosynthesis_Homo sapiens_hsa001000.84651638
52Pyrimidine metabolism_Homo sapiens_hsa002400.83288187
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82887751
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80105803
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78787805
56Fanconi anemia pathway_Homo sapiens_hsa034600.78761699
57Circadian entrainment_Homo sapiens_hsa047130.78644318
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74854077
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73319352
60Vitamin B6 metabolism_Homo sapiens_hsa007500.73299177
61Fatty acid degradation_Homo sapiens_hsa000710.73044418
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70995267
63One carbon pool by folate_Homo sapiens_hsa006700.70960630
64Serotonergic synapse_Homo sapiens_hsa047260.70129642
65Ether lipid metabolism_Homo sapiens_hsa005650.69891158
66Mismatch repair_Homo sapiens_hsa034300.69071077
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.68556430
68Olfactory transduction_Homo sapiens_hsa047400.68448131
69Pyruvate metabolism_Homo sapiens_hsa006200.68021409
70Glutathione metabolism_Homo sapiens_hsa004800.68004739
71Taste transduction_Homo sapiens_hsa047420.67475527
72Dopaminergic synapse_Homo sapiens_hsa047280.65681705
73Retinol metabolism_Homo sapiens_hsa008300.65140453
74Nucleotide excision repair_Homo sapiens_hsa034200.63449311
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61898632
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61470271
77Glutamatergic synapse_Homo sapiens_hsa047240.60010361
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54963909
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.54277521
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54219874
81Fatty acid metabolism_Homo sapiens_hsa012120.53534057
82Amphetamine addiction_Homo sapiens_hsa050310.52373578
83Arachidonic acid metabolism_Homo sapiens_hsa005900.52232506
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48823169
85Salivary secretion_Homo sapiens_hsa049700.47523702
86Hedgehog signaling pathway_Homo sapiens_hsa043400.47460303
87Mineral absorption_Homo sapiens_hsa049780.45282647
88Type I diabetes mellitus_Homo sapiens_hsa049400.43792560
89Cocaine addiction_Homo sapiens_hsa050300.42678416
90Tyrosine metabolism_Homo sapiens_hsa003500.42178866
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40317689
92Non-homologous end-joining_Homo sapiens_hsa034500.38365784
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37719484
94Base excision repair_Homo sapiens_hsa034100.35183700
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35018699
96RNA transport_Homo sapiens_hsa030130.34341979
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32411507
98Arginine and proline metabolism_Homo sapiens_hsa003300.31371509
99Rheumatoid arthritis_Homo sapiens_hsa053230.31049108
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30492393

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