C2ORF70

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)7.52570594
2response to pheromone (GO:0019236)7.05662685
3motile cilium assembly (GO:0044458)6.53312443
4cilium movement (GO:0003341)5.85144716
5cobalamin metabolic process (GO:0009235)5.84105257
6cilium or flagellum-dependent cell motility (GO:0001539)5.48254243
7regulation of cilium movement (GO:0003352)5.46584440
8axoneme assembly (GO:0035082)5.13455752
9epithelial cilium movement (GO:0003351)5.12591508
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.93720553
11sperm motility (GO:0030317)4.55074111
12long term synaptic depression (GO:0060292)4.53399230
13protein localization to Golgi apparatus (GO:0034067)4.45217801
14calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.14880567
15regulation of microtubule-based movement (GO:0060632)4.14396439
16synapsis (GO:0007129)4.13027321
17platelet dense granule organization (GO:0060155)4.10511611
18protein targeting to Golgi (GO:0000042)4.00876459
19cell morphogenesis involved in neuron differentiation (GO:0048667)3.96897203
20regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.92973968
21acrosome reaction (GO:0007340)3.86634660
22establishment of protein localization to Golgi (GO:0072600)3.75321167
23digestion (GO:0007586)3.74125682
24adult feeding behavior (GO:0008343)3.68718433
25male sex determination (GO:0030238)3.61163847
26mesenchymal cell differentiation involved in renal system development (GO:2001012)3.59525467
27mesenchymal cell differentiation involved in kidney development (GO:0072161)3.59525467
28negative regulation of inclusion body assembly (GO:0090084)3.57811199
29retrograde transport, vesicle recycling within Golgi (GO:0000301)3.56211783
30negative regulation of gene silencing (GO:0060969)3.55590797
31regulation of type B pancreatic cell apoptotic process (GO:2000674)3.47011730
32negative regulation of hormone biosynthetic process (GO:0032353)3.45790791
33male meiosis I (GO:0007141)3.45264476
34sperm capacitation (GO:0048240)3.41092179
35nucleoside diphosphate catabolic process (GO:0009134)3.40595247
36intraciliary transport (GO:0042073)3.34997500
37regulation of male gonad development (GO:2000018)3.33642020
38glutathione biosynthetic process (GO:0006750)3.33442029
39regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)3.33146425
40fusion of sperm to egg plasma membrane (GO:0007342)3.32727709
41glandular epithelial cell development (GO:0002068)3.29624144
42microtubule polymerization or depolymerization (GO:0031109)3.27754259
43cilium assembly (GO:0042384)3.17602662
44protein localization to cilium (GO:0061512)3.17507082
45cilium organization (GO:0044782)3.16996442
46regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.16607725
47negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.15140040
48intestinal cholesterol absorption (GO:0030299)3.13849851
49phosphatidylethanolamine biosynthetic process (GO:0006646)3.12347541
50negative regulation of hormone metabolic process (GO:0032351)3.10111484
51negative regulation of acute inflammatory response (GO:0002674)3.09990961
52multicellular organism reproduction (GO:0032504)3.04518995
53regulation of response to food (GO:0032095)3.03881046
54spermatid development (GO:0007286)3.03479903
55maintenance of gastrointestinal epithelium (GO:0030277)3.02789895
56endocrine pancreas development (GO:0031018)3.02725842
57cellular ketone body metabolic process (GO:0046950)3.02424450
58positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.00234287
59retinol metabolic process (GO:0042572)2.99007241
60cell proliferation involved in kidney development (GO:0072111)2.98334762
61cysteine metabolic process (GO:0006534)2.97093472
62phosphatidylethanolamine metabolic process (GO:0046337)2.93382908
63dopamine transport (GO:0015872)2.91194683
64microtubule depolymerization (GO:0007019)2.89788180
65lung epithelium development (GO:0060428)2.88359784
66cell proliferation involved in metanephros development (GO:0072203)2.88124626
67meiosis I (GO:0007127)2.87235802
68negative regulation of cytosolic calcium ion concentration (GO:0051481)2.86817873
69diterpenoid biosynthetic process (GO:0016102)2.85935926
70left/right pattern formation (GO:0060972)2.83143646
71piRNA metabolic process (GO:0034587)2.82778974
72leukotriene biosynthetic process (GO:0019370)2.82270485
73ventricular system development (GO:0021591)2.77684280
74nonmotile primary cilium assembly (GO:0035058)2.76779067
75nonribosomal peptide biosynthetic process (GO:0019184)2.75853939
76intra-Golgi vesicle-mediated transport (GO:0006891)2.75008510
77epithelial cell fate commitment (GO:0072148)2.72757870
78regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.72550696
79regulation of metalloenzyme activity (GO:0048552)2.70693489
80inner ear receptor cell differentiation (GO:0060113)2.69457140
81insulin secretion (GO:0030073)2.69419434
82negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.67933325
83regulation of cellular amino acid metabolic process (GO:0006521)2.67865258
84ketone body metabolic process (GO:1902224)2.67728082
85glandular epithelial cell differentiation (GO:0002067)2.67590942
86peptidyl-threonine dephosphorylation (GO:0035970)2.63386955
87columnar/cuboidal epithelial cell development (GO:0002066)2.63164409
88one-carbon compound transport (GO:0019755)2.62876147
89negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.61392332
90calcium ion-dependent exocytosis (GO:0017156)2.59414503
91DNA methylation involved in gamete generation (GO:0043046)2.59092049
92rRNA methylation (GO:0031167)2.57999617
93cell differentiation involved in metanephros development (GO:0072202)2.56638669
94microtubule bundle formation (GO:0001578)2.55432731
95sperm-egg recognition (GO:0035036)2.54050771
96artery smooth muscle contraction (GO:0014824)2.53629671
97regulation of beta-amyloid formation (GO:1902003)2.52600900
98male meiosis (GO:0007140)2.52011912
99post-embryonic morphogenesis (GO:0009886)2.50527751
100spermatogenesis (GO:0007283)2.49833344

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.57790123
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.87692534
3VDR_22108803_ChIP-Seq_LS180_Human3.41695763
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.08613605
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.54009746
6BMI1_23680149_ChIP-Seq_NPCS_Mouse2.24805346
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.20901126
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.16164524
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11215469
10CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90341747
11PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88380512
12RBPJ_22232070_ChIP-Seq_NCS_Mouse1.86073223
13BCAT_22108803_ChIP-Seq_LS180_Human1.85099077
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84442491
15FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.67357267
16POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64699380
17SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.64360925
18TAF15_26573619_Chip-Seq_HEK293_Human1.61722324
19ARNT_22903824_ChIP-Seq_MCF-7_Human1.58981737
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.57228399
21SMAD3_21741376_ChIP-Seq_EPCs_Human1.50701499
22ER_23166858_ChIP-Seq_MCF-7_Human1.49791389
23AR_25329375_ChIP-Seq_VCAP_Human1.46547070
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.45307528
25FOXA1_27270436_Chip-Seq_PROSTATE_Human1.44399355
26FOXA1_25329375_ChIP-Seq_VCAP_Human1.44399355
27ERA_21632823_ChIP-Seq_H3396_Human1.40952288
28AHR_22903824_ChIP-Seq_MCF-7_Human1.40943964
29SMAD4_21741376_ChIP-Seq_EPCs_Human1.40303191
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.37079648
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.35230439
32CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.35106677
33ZNF274_21170338_ChIP-Seq_K562_Hela1.33976533
34GBX2_23144817_ChIP-Seq_PC3_Human1.33288871
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.31880200
36P300_19829295_ChIP-Seq_ESCs_Human1.29059842
37ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29040369
38DROSHA_22980978_ChIP-Seq_HELA_Human1.27424331
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27365448
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.26950243
41SOX2_19829295_ChIP-Seq_ESCs_Human1.26340273
42NANOG_19829295_ChIP-Seq_ESCs_Human1.26340273
43FOXA1_21572438_ChIP-Seq_LNCaP_Human1.25083332
44FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.24427204
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22871434
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22097211
47FUS_26573619_Chip-Seq_HEK293_Human1.21877162
48TCF4_22108803_ChIP-Seq_LS180_Human1.21543388
49GATA4_25053715_ChIP-Seq_YYC3_Human1.21248879
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20051748
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.20047245
52TP53_18474530_ChIP-ChIP_U2OS_Human1.19882229
53FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19486248
54RXR_22108803_ChIP-Seq_LS180_Human1.16712462
55RUNX2_22187159_ChIP-Seq_PCA_Human1.15990923
56* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15239216
57SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.15165878
58RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14926669
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14219397
60HOXB7_26014856_ChIP-Seq_BT474_Human1.12510137
61RNF2_27304074_Chip-Seq_NSC_Mouse1.11859208
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10653156
63* CBP_20019798_ChIP-Seq_JUKART_Human1.10323649
64* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10323649
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.10150102
66AR_20517297_ChIP-Seq_VCAP_Human1.08654083
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08253655
68ETV1_20927104_ChIP-Seq_GIST48_Human1.07185132
69TRIM28_21343339_ChIP-Seq_HEK293_Human1.06647785
70SMAD4_21799915_ChIP-Seq_A2780_Human1.05963174
71SOX2_22085726_ChIP-Seq_NPCs_Mouse1.03864104
72TAF2_19829295_ChIP-Seq_ESCs_Human1.03541426
73* KLF5_25053715_ChIP-Seq_YYC3_Human1.03429713
74PHF8_20622853_ChIP-Seq_HELA_Human1.03158015
75FOXA1_25552417_ChIP-Seq_VCAP_Human1.02488778
76CDX2_22108803_ChIP-Seq_LS180_Human1.02342026
77SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01580438
78TP53_22573176_ChIP-Seq_HFKS_Human0.99876831
79JARID2_20075857_ChIP-Seq_MESCs_Mouse0.99374030
80FOXH1_21741376_ChIP-Seq_EPCs_Human0.97909341
81MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97906990
82EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97684341
83PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.97274084
84SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97012373
85* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96552905
86STAT3_18555785_Chip-Seq_ESCs_Mouse0.96349126
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95555242
88RBPJ_21746931_ChIP-Seq_IB4_Human0.94345396
89E2F1_20622854_ChIP-Seq_HELA_Human0.94033257
90* MYC_19829295_ChIP-Seq_ESCs_Human0.93315389
91OCT4_20526341_ChIP-Seq_ESCs_Human0.92835413
92ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92774061
93P300_27268052_Chip-Seq_Bcells_Human0.92185730
94NANOG_18555785_Chip-Seq_ESCs_Mouse0.91475245
95SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90953576
96NANOG_20526341_ChIP-Seq_ESCs_Human0.90104107
97FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88808886
98ERG_20517297_ChIP-Seq_VCAP_Human0.88731180
99TP63_23658742_ChIP-Seq_EP156T_Human0.86832862
100REST_21632747_ChIP-Seq_MESCs_Mouse0.86501580

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis4.79862703
2MP0009780_abnormal_chondrocyte_physiolo4.71049299
3MP0003011_delayed_dark_adaptation4.48497750
4MP0003283_abnormal_digestive_organ4.31302979
5MP0002909_abnormal_adrenal_gland3.24185379
6MP0002876_abnormal_thyroid_physiology3.15883112
7MP0005083_abnormal_biliary_tract2.98823691
8MP0003136_yellow_coat_color2.79554468
9MP0005410_abnormal_fertilization2.44239432
10MP0005670_abnormal_white_adipose2.24229517
11MP0002282_abnormal_trachea_morphology2.21397526
12MP0001661_extended_life_span2.08604481
13MP0005379_endocrine/exocrine_gland_phen2.05934503
14MP0006072_abnormal_retinal_apoptosis2.00552820
15MP0005253_abnormal_eye_physiology1.95913149
16MP0010678_abnormal_skin_adnexa1.95182188
17MP0008875_abnormal_xenobiotic_pharmacok1.87907152
18MP0000383_abnormal_hair_follicle1.85979059
19MP0000462_abnormal_digestive_system1.82225637
20MP0001944_abnormal_pancreas_morphology1.78001684
21MP0000013_abnormal_adipose_tissue1.75232275
22MP0005645_abnormal_hypothalamus_physiol1.74225355
23MP0002163_abnormal_gland_morphology1.72317955
24MP0002822_catalepsy1.72154563
25MP0001929_abnormal_gametogenesis1.71620682
26MP0010234_abnormal_vibrissa_follicle1.70536451
27MP0002249_abnormal_larynx_morphology1.67631617
28MP0005451_abnormal_body_composition1.66162483
29MP0001984_abnormal_olfaction1.64200894
30MP0004043_abnormal_pH_regulation1.59873983
31MP0005551_abnormal_eye_electrophysiolog1.53227235
32MP0000613_abnormal_salivary_gland1.50429257
33MP0003698_abnormal_male_reproductive1.46982053
34MP0000427_abnormal_hair_cycle1.45137408
35MP0002638_abnormal_pupillary_reflex1.42516411
36MP0001485_abnormal_pinna_reflex1.40619543
37MP0005257_abnormal_intraocular_pressure1.39120236
38MP0002928_abnormal_bile_duct1.36640532
39MP0003195_calcinosis1.35660406
40MP0005248_abnormal_Harderian_gland1.34492541
41MP0008877_abnormal_DNA_methylation1.34030825
42MP0001664_abnormal_digestion1.29801794
43MP0002210_abnormal_sex_determination1.28624778
44MP0000569_abnormal_digit_pigmentation1.27278904
45MP0001765_abnormal_ion_homeostasis1.25474251
46MP0004019_abnormal_vitamin_homeostasis1.24968955
47MP0005085_abnormal_gallbladder_physiolo1.24826560
48MP0010030_abnormal_orbit_morphology1.23115414
49MP0001905_abnormal_dopamine_level1.20716867
50MP0010386_abnormal_urinary_bladder1.17855095
51MP0005075_abnormal_melanosome_morpholog1.17316768
52MP0000538_abnormal_urinary_bladder1.16834399
53MP0002332_abnormal_exercise_endurance1.13511176
54MP0003119_abnormal_digestive_system1.12854203
55MP0000647_abnormal_sebaceous_gland1.08620397
56MP0002735_abnormal_chemical_nociception1.04450241
57MP0002693_abnormal_pancreas_physiology1.02673670
58MP0005636_abnormal_mineral_homeostasis1.02648515
59MP0001666_abnormal_nutrient_absorption1.02105671
60MP0000653_abnormal_sex_gland1.00589746
61MP0000026_abnormal_inner_ear1.00440015
62MP0003123_paternal_imprinting0.99148627
63MP0001145_abnormal_male_reproductive0.98826881
64MP0003806_abnormal_nucleotide_metabolis0.96757428
65MP0001963_abnormal_hearing_physiology0.95842471
66MP0002098_abnormal_vibrissa_morphology0.94733234
67MP0005332_abnormal_amino_acid0.94605925
68MP0003866_abnormal_defecation0.94456214
69MP0009046_muscle_twitch0.93808446
70MP0002229_neurodegeneration0.93348367
71MP0005365_abnormal_bile_salt0.90824211
72MP0003936_abnormal_reproductive_system0.89883530
73MP0002067_abnormal_sensory_capabilities0.88262070
74MP0000631_abnormal_neuroendocrine_gland0.88235625
75MP0006036_abnormal_mitochondrial_physio0.85939050
76MP0002837_dystrophic_cardiac_calcinosis0.84916211
77MP0003656_abnormal_erythrocyte_physiolo0.84729270
78MP0003718_maternal_effect0.83946403
79MP0003943_abnormal_hepatobiliary_system0.83405781
80MP0005391_vision/eye_phenotype0.81952055
81MP0003953_abnormal_hormone_level0.79663113
82MP0000371_diluted_coat_color0.79425644
83MP0006292_abnormal_olfactory_placode0.77152431
84MP0000681_abnormal_thyroid_gland0.76695886
85MP0005220_abnormal_exocrine_pancreas0.76510946
86MP0003879_abnormal_hair_cell0.75818617
87MP0005310_abnormal_salivary_gland0.75231236
88MP0003938_abnormal_ear_development0.75168057
89MP0000639_abnormal_adrenal_gland0.74444438
90MP0009745_abnormal_behavioral_response0.74279707
91MP0010329_abnormal_lipoprotein_level0.70804934
92MP0003252_abnormal_bile_duct0.70709694
93MP0000516_abnormal_urinary_system0.69837826
94MP0005367_renal/urinary_system_phenotyp0.69837826
95MP0002734_abnormal_mechanical_nocicepti0.67938688
96MP0002095_abnormal_skin_pigmentation0.67584111
97MP0001970_abnormal_pain_threshold0.63693824
98MP0002078_abnormal_glucose_homeostasis0.63434639
99MP0006276_abnormal_autonomic_nervous0.63203406
100MP0002161_abnormal_fertility/fecundity0.62897660

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.18714476
2Abnormal ciliary motility (HP:0012262)5.74217157
3Abnormal respiratory motile cilium physiology (HP:0012261)5.59176035
4Dynein arm defect of respiratory motile cilia (HP:0012255)5.34185185
5Absent/shortened dynein arms (HP:0200106)5.34185185
6Abnormal respiratory epithelium morphology (HP:0012253)5.33122512
7Abnormal respiratory motile cilium morphology (HP:0005938)5.33122512
8Rhinitis (HP:0012384)4.97994657
9Congenital stationary night blindness (HP:0007642)4.28348753
10Glucose intolerance (HP:0000833)3.67565693
11Nasal polyposis (HP:0100582)3.65438834
12Abnormal sex determination (HP:0012244)3.62079348
13Sex reversal (HP:0012245)3.62079348
14Chronic bronchitis (HP:0004469)3.61882217
15Abnormal pancreas size (HP:0012094)3.53837560
16Congenital, generalized hypertrichosis (HP:0004540)3.45800868
17Bronchiectasis (HP:0002110)3.45675114
18Chronic sinusitis (HP:0011109)3.45397937
19Tubulointerstitial nephritis (HP:0001970)3.42820850
20True hermaphroditism (HP:0010459)3.35259813
21Abnormality of the distal phalanges of the toes (HP:0010182)3.14046730
22Exocrine pancreatic insufficiency (HP:0001738)3.00371676
23Insulin-resistant diabetes mellitus (HP:0000831)2.91821376
24Type II lissencephaly (HP:0007260)2.87915770
25Hypokinesia (HP:0002375)2.80562966
26Bronchitis (HP:0012387)2.74281674
27Abnormality of the renal cortex (HP:0011035)2.73060552
28Abnormality of the nasal mucosa (HP:0000433)2.70370563
29Tubular atrophy (HP:0000092)2.61874565
30Congenital sensorineural hearing impairment (HP:0008527)2.60456313
31Steatorrhea (HP:0002570)2.60102619
32Medial flaring of the eyebrow (HP:0010747)2.54988762
33Gait imbalance (HP:0002141)2.51892136
34Pili torti (HP:0003777)2.51103641
35Chronic hepatic failure (HP:0100626)2.50700674
36Pancreatic fibrosis (HP:0100732)2.49915839
37Broad face (HP:0000283)2.45733723
38Short nail (HP:0001799)2.42684732
39Abnormal glucose tolerance (HP:0001952)2.40598836
40Bell-shaped thorax (HP:0001591)2.37970391
41Abnormality of the renal medulla (HP:0100957)2.37598335
42Hyperkalemia (HP:0002153)2.37306244
43Congenital primary aphakia (HP:0007707)2.35214292
44Disproportionate short-trunk short stature (HP:0003521)2.34931573
45Growth hormone excess (HP:0000845)2.32980383
46Menstrual irregularities (HP:0000858)2.29512989
47Nephronophthisis (HP:0000090)2.27933906
48Pancreatic cysts (HP:0001737)2.26874137
49Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.25094607
50Infertility (HP:0000789)2.21564303
51Abnormal hair laboratory examination (HP:0003328)2.18686278
52Hepatocellular necrosis (HP:0001404)2.18140738
53Depressed nasal tip (HP:0000437)2.17077041
54Median cleft lip (HP:0000161)2.15939364
55Down-sloping shoulders (HP:0200021)2.15313540
56Recurrent bronchitis (HP:0002837)2.14056301
57Fetal akinesia sequence (HP:0001989)2.13183662
58Hepatic necrosis (HP:0002605)2.12546830
59Abnormality of the middle phalanges of the toes (HP:0010183)2.11778270
60Recurrent otitis media (HP:0000403)2.11712211
61Hypoproteinemia (HP:0003075)2.09511546
62Hypoplasia of the pons (HP:0012110)2.09119190
63Retinal dysplasia (HP:0007973)2.06936473
64Optic nerve coloboma (HP:0000588)2.03488400
65Amelogenesis imperfecta (HP:0000705)2.01702964
66Hypomagnesemia (HP:0002917)2.01178031
67Azoospermia (HP:0000027)1.99909351
68Occipital encephalocele (HP:0002085)1.97804407
69Molar tooth sign on MRI (HP:0002419)1.95937165
70Abnormality of midbrain morphology (HP:0002418)1.95937165
71Acanthocytosis (HP:0001927)1.92817585
72Adrenal hypoplasia (HP:0000835)1.92121763
73Cystic liver disease (HP:0006706)1.91330759
74Fat malabsorption (HP:0002630)1.91265774
75Axonal loss (HP:0003447)1.90833023
76Nephrogenic diabetes insipidus (HP:0009806)1.90670478
77Abnormality of macular pigmentation (HP:0008002)1.88181083
78Goiter (HP:0000853)1.88049598
79Anophthalmia (HP:0000528)1.86724536
80Gout (HP:0001997)1.85415295
81Glossoptosis (HP:0000162)1.85240927
82Recurrent sinusitis (HP:0011108)1.83275699
83Increased purine levels (HP:0004368)1.82200006
84Hyperuricemia (HP:0002149)1.82200006
85Tongue fasciculations (HP:0001308)1.82198465
86Male pseudohermaphroditism (HP:0000037)1.82120458
87Insulin resistance (HP:0000855)1.79832087
88Abnormality of the pons (HP:0007361)1.79733232
89Woolly hair (HP:0002224)1.78708124
90Mitochondrial inheritance (HP:0001427)1.77548741
91Genital tract atresia (HP:0001827)1.75269165
92Vaginal atresia (HP:0000148)1.73723751
93Sparse eyelashes (HP:0000653)1.73466345
94Unilateral renal agenesis (HP:0000122)1.72380276
95Increased CSF lactate (HP:0002490)1.71890930
96Sclerocornea (HP:0000647)1.70770963
97Hydroxyprolinuria (HP:0003080)1.70559727
98Abnormality of proline metabolism (HP:0010907)1.70559727
99Aplasia/hypoplasia of the uterus (HP:0008684)1.69707989
100Abnormality of magnesium homeostasis (HP:0004921)1.68255561

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK26.88845959
2NME15.93569517
3MST1R4.13060155
4MST43.53511327
5STK38L3.05075002
6GRK13.04704857
7MAPK152.91825993
8EPHA22.66100647
9PNCK2.43940734
10PINK12.43241800
11BMPR1B2.33366786
12PASK2.23481792
13MAPKAPK31.95522085
14FRK1.87482504
15MAP3K61.80520415
16STK241.80013306
17ACVR1B1.78021914
18TRIM281.76321080
19MAP3K21.75723836
20STK381.73626829
21MET1.57544010
22WNK41.50471850
23MAP4K21.44693310
24PHKG11.43137631
25PHKG21.43137631
26TESK11.39421832
27PLK41.34211354
28TRPM71.28514361
29CDK81.25208433
30EIF2AK11.22608215
31ZAK1.15749570
32ERBB31.12638901
33MAP2K61.10865849
34MAP3K91.10064580
35FGFR21.06787906
36VRK21.03089424
37WNK10.99794666
38TSSK60.96008598
39STK160.87931092
40PLK20.86255644
41MAP2K20.85910292
42INSRR0.85791774
43PRKCI0.84198604
44PTK2B0.83160864
45TNIK0.77576583
46MAP3K120.74824823
47CASK0.72653375
48LMTK20.67261266
49CAMK1G0.67255400
50HIPK20.53234563
51DYRK30.53157861
52CAMK1D0.51413541
53SIK10.51239254
54ADRBK10.50614569
55EIF2AK20.48814207
56DAPK10.46760097
57GRK70.43683302
58MAP2K10.43354078
59STK390.42026864
60MAP3K40.38327416
61PBK0.36344872
62DYRK20.35341429
63WEE10.35179265
64CAMK2D0.34433815
65ADRBK20.33699245
66CCNB10.33468277
67STK30.31541772
68ABL20.29456704
69PTK20.27874077
70EIF2AK30.27834507
71ROCK10.27288190
72STK100.27013599
73LATS20.26926603
74ZAP700.26888847
75FER0.25502665
76PRKG20.25487631
77OXSR10.25438265
78TTK0.24207083
79LRRK20.24205878
80PDGFRB0.20682315
81PRKACA0.20486544
82LIMK10.19727279
83SGK10.17798630
84CAMK2G0.17596982
85ERBB20.16973397
86PRKCG0.16214550
87BRSK20.15556730
88ICK0.15261139
89MAP3K30.15205314
90IGF1R0.14813130
91MAP2K40.13730339
92PRKCE0.12589051
93RPS6KA50.12178556
94TBK10.11740245
95FGFR10.11499944
96NTRK30.11483693
97PRKCQ0.10621009
98TGFBR10.10450920
99ERBB40.10028343
100CAMK2A0.09834523

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.35877236
2Sulfur metabolism_Homo sapiens_hsa009203.92312761
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.58834256
4Phototransduction_Homo sapiens_hsa047442.63432470
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.60913523
6Protein export_Homo sapiens_hsa030602.42617689
7Folate biosynthesis_Homo sapiens_hsa007902.29564086
8Proteasome_Homo sapiens_hsa030502.23874232
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.17997568
10Regulation of autophagy_Homo sapiens_hsa041401.74061665
11Insulin secretion_Homo sapiens_hsa049111.71049234
12Fatty acid biosynthesis_Homo sapiens_hsa000611.69517136
13Oxidative phosphorylation_Homo sapiens_hsa001901.67531443
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.65820004
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.61533904
16Huntingtons disease_Homo sapiens_hsa050161.56275491
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.52504577
18Pancreatic secretion_Homo sapiens_hsa049721.50946536
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.50337214
20Thyroid hormone synthesis_Homo sapiens_hsa049181.49139370
21Caffeine metabolism_Homo sapiens_hsa002321.43773288
22Selenocompound metabolism_Homo sapiens_hsa004501.39449847
23Sulfur relay system_Homo sapiens_hsa041221.37291032
24Glutathione metabolism_Homo sapiens_hsa004801.35737851
25Retinol metabolism_Homo sapiens_hsa008301.34796856
26Protein digestion and absorption_Homo sapiens_hsa049741.31740670
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30167194
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28035690
29Nicotine addiction_Homo sapiens_hsa050331.27014240
30Sphingolipid metabolism_Homo sapiens_hsa006001.26737472
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25583077
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25072020
33Hedgehog signaling pathway_Homo sapiens_hsa043401.24431975
34Taste transduction_Homo sapiens_hsa047421.18932911
35Parkinsons disease_Homo sapiens_hsa050121.16863077
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13907751
37Chemical carcinogenesis_Homo sapiens_hsa052041.13707559
38Legionellosis_Homo sapiens_hsa051341.12976697
39Butanoate metabolism_Homo sapiens_hsa006501.09444211
40Cardiac muscle contraction_Homo sapiens_hsa042601.06702068
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03510236
42Nitrogen metabolism_Homo sapiens_hsa009101.01479241
43Type II diabetes mellitus_Homo sapiens_hsa049301.00327563
44Type I diabetes mellitus_Homo sapiens_hsa049400.99521015
45ABC transporters_Homo sapiens_hsa020100.97464336
46Mineral absorption_Homo sapiens_hsa049780.96568211
47Olfactory transduction_Homo sapiens_hsa047400.93911450
48Purine metabolism_Homo sapiens_hsa002300.93171934
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88933246
50beta-Alanine metabolism_Homo sapiens_hsa004100.88572988
51Alzheimers disease_Homo sapiens_hsa050100.87647329
52Peroxisome_Homo sapiens_hsa041460.87621610
53Phenylalanine metabolism_Homo sapiens_hsa003600.86769047
54Basal transcription factors_Homo sapiens_hsa030220.84790070
55Circadian rhythm_Homo sapiens_hsa047100.83377270
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.80978162
57Collecting duct acid secretion_Homo sapiens_hsa049660.80186169
58Tyrosine metabolism_Homo sapiens_hsa003500.79632748
59N-Glycan biosynthesis_Homo sapiens_hsa005100.75424983
60Serotonergic synapse_Homo sapiens_hsa047260.74361309
61Propanoate metabolism_Homo sapiens_hsa006400.74211177
62Bile secretion_Homo sapiens_hsa049760.73598800
63Tight junction_Homo sapiens_hsa045300.73044060
64Ovarian steroidogenesis_Homo sapiens_hsa049130.72825894
65Salivary secretion_Homo sapiens_hsa049700.72394279
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68492314
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66581219
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64590228
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63822997
70Histidine metabolism_Homo sapiens_hsa003400.63536577
71Metabolic pathways_Homo sapiens_hsa011000.63388577
72One carbon pool by folate_Homo sapiens_hsa006700.62286875
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62263060
74Cocaine addiction_Homo sapiens_hsa050300.60904500
75Pyruvate metabolism_Homo sapiens_hsa006200.60608333
76Fatty acid elongation_Homo sapiens_hsa000620.60151434
77Synaptic vesicle cycle_Homo sapiens_hsa047210.59007290
78GABAergic synapse_Homo sapiens_hsa047270.57035340
79Arachidonic acid metabolism_Homo sapiens_hsa005900.55913226
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.54533212
81Linoleic acid metabolism_Homo sapiens_hsa005910.54430274
82Morphine addiction_Homo sapiens_hsa050320.52456609
83Pyrimidine metabolism_Homo sapiens_hsa002400.49970341
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48850706
85Vibrio cholerae infection_Homo sapiens_hsa051100.48435559
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.46918531
87Homologous recombination_Homo sapiens_hsa034400.42662520
88Basal cell carcinoma_Homo sapiens_hsa052170.42621588
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41280817
90Nucleotide excision repair_Homo sapiens_hsa034200.40702937
91PPAR signaling pathway_Homo sapiens_hsa033200.39913028
92cAMP signaling pathway_Homo sapiens_hsa040240.39346103
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39346082
94Glycerolipid metabolism_Homo sapiens_hsa005610.39183555
95Renin secretion_Homo sapiens_hsa049240.37514313
96Ether lipid metabolism_Homo sapiens_hsa005650.35204400
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34999359
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.33717894
99Amphetamine addiction_Homo sapiens_hsa050310.33031441
100Circadian entrainment_Homo sapiens_hsa047130.28641826

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