C2ORF57

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm capacitation (GO:0048240)9.68652349
2chromosome condensation (GO:0030261)9.32233352
3DNA packaging (GO:0006323)9.11863448
4spermatid development (GO:0007286)8.68435684
5single strand break repair (GO:0000012)8.31558061
6spermatid nucleus differentiation (GO:0007289)8.23245733
7microtubule depolymerization (GO:0007019)8.13999940
8plasma membrane fusion (GO:0045026)8.08986752
9response to pheromone (GO:0019236)7.72743356
10rRNA methylation (GO:0031167)7.60605333
11sperm-egg recognition (GO:0035036)7.48498533
12protein polyglutamylation (GO:0018095)7.45957175
13multicellular organism reproduction (GO:0032504)7.24071301
14phosphatidylethanolamine biosynthetic process (GO:0006646)7.11408441
15protein targeting to Golgi (GO:0000042)7.05431536
16negative regulation of inclusion body assembly (GO:0090084)6.95667914
17reproduction (GO:0000003)6.88946719
18sexual reproduction (GO:0019953)6.87013450
19binding of sperm to zona pellucida (GO:0007339)6.79991378
20establishment of protein localization to Golgi (GO:0072600)6.76314167
21microtubule polymerization or depolymerization (GO:0031109)6.73626808
22retrograde transport, vesicle recycling within Golgi (GO:0000301)6.58756888
23phosphatidylethanolamine metabolic process (GO:0046337)6.58615443
24calcium ion-dependent exocytosis (GO:0017156)6.55342258
25rRNA modification (GO:0000154)6.41449583
26microtubule severing (GO:0051013)6.35509590
27axonemal dynein complex assembly (GO:0070286)6.33545356
28spermatogenesis (GO:0007283)6.23097540
29male gamete generation (GO:0048232)6.20958050
30cell-cell recognition (GO:0009988)6.16263001
31gamete generation (GO:0007276)5.69316512
32regulation of cilium movement (GO:0003352)5.63730326
33centriole replication (GO:0007099)5.52840128
34cellular ketone body metabolic process (GO:0046950)5.44980734
35single fertilization (GO:0007338)5.10685283
36RNA destabilization (GO:0050779)5.05954199
37protein localization to Golgi apparatus (GO:0034067)5.05174768
38cilium or flagellum-dependent cell motility (GO:0001539)5.00452995
39motile cilium assembly (GO:0044458)4.98405460
40regulation of inclusion body assembly (GO:0090083)4.97733110
41centriole assembly (GO:0098534)4.97502602
42positive regulation of Rab GTPase activity (GO:0032851)4.91374884
43regulation of Rab GTPase activity (GO:0032313)4.91374884
44germ cell development (GO:0007281)4.86904277
45cell wall macromolecule catabolic process (GO:0016998)4.85711707
46ketone body metabolic process (GO:1902224)4.80654173
47cell wall macromolecule metabolic process (GO:0044036)4.60140875
48cellular process involved in reproduction in multicellular organism (GO:0022412)4.59466834
49multicellular organismal reproductive process (GO:0048609)4.58800667
50regulation of transcription involved in cell fate commitment (GO:0060850)4.51246411
51regulation of centriole replication (GO:0046599)4.51084436
52nucleus organization (GO:0006997)4.38530282
53chromatin silencing (GO:0006342)4.37741807
54epithelial cilium movement (GO:0003351)4.34547439
55fertilization (GO:0009566)4.27979385
56seminiferous tubule development (GO:0072520)4.12701428
57regulation of microtubule-based movement (GO:0060632)4.01279184
58organic cation transport (GO:0015695)3.99618184
59multicellular organismal movement (GO:0050879)3.85695704
60musculoskeletal movement (GO:0050881)3.85695704
61polyamine biosynthetic process (GO:0006596)3.78981418
62cilium movement (GO:0003341)3.78769734
63antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.71595408
64nucleosome disassembly (GO:0006337)3.65883173
65protein-DNA complex disassembly (GO:0032986)3.65883173
66response to acidic pH (GO:0010447)3.62345524
67membrane protein intracellular domain proteolysis (GO:0031293)3.51103580
68coenzyme catabolic process (GO:0009109)3.40365830
69peptidyl-threonine dephosphorylation (GO:0035970)3.39568168
70cellular response to pH (GO:0071467)3.38033279
71microtubule nucleation (GO:0007020)3.37516426
72glycerol ether metabolic process (GO:0006662)3.34913777
73homeostasis of number of cells within a tissue (GO:0048873)3.32456262
74negative regulation of Rho protein signal transduction (GO:0035024)3.30837216
75cerebral cortex neuron differentiation (GO:0021895)3.26726607
76glomerular visceral epithelial cell development (GO:0072015)3.22928358
77regulation of interleukin-13 production (GO:0032656)3.22098890
78multicellular organismal development (GO:0007275)3.17300560
79glomerular epithelial cell development (GO:0072310)3.13882827
80cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.12173879
81ether metabolic process (GO:0018904)3.08505300
82regulation of T-helper 2 cell differentiation (GO:0045628)3.08099900
83histone H3-K9 demethylation (GO:0033169)3.05934680
84protein depolymerization (GO:0051261)3.05528768
85regulation of phosphoprotein phosphatase activity (GO:0043666)3.03305601
86negative regulation of gene expression, epigenetic (GO:0045814)2.96570658
87cell recognition (GO:0008037)2.96434720
88DNA conformation change (GO:0071103)2.92742635
89cranial nerve morphogenesis (GO:0021602)2.91951184
90mitochondrial fission (GO:0000266)2.89720996
91regulation of somitogenesis (GO:0014807)2.80370870
92receptor recycling (GO:0001881)2.78377876
93mitotic G1 DNA damage checkpoint (GO:0031571)2.77869530
94positive regulation of guanylate cyclase activity (GO:0031284)2.76335412
95Golgi to endosome transport (GO:0006895)2.74895085
96RNA localization (GO:0006403)2.72064115
97ventricular system development (GO:0021591)2.66756799
98sperm motility (GO:0030317)12.4169966
99acrosome reaction (GO:0007340)12.1089471
100fusion of sperm to egg plasma membrane (GO:0007342)10.6615747

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.55226759
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.97428845
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.50179709
4TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.44000157
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.44000157
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.28152389
7EZH2_22144423_ChIP-Seq_EOC_Human2.24557934
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21918403
9VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.21574831
10CBP_20019798_ChIP-Seq_JUKART_Human2.19310160
11IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.19310160
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14063228
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06226826
14ELF1_20517297_ChIP-Seq_JURKAT_Human2.04044821
15DROSHA_22980978_ChIP-Seq_HELA_Human1.94016853
16FUS_26573619_Chip-Seq_HEK293_Human1.90698782
17ERA_21632823_ChIP-Seq_H3396_Human1.86517887
18CTCF_27219007_Chip-Seq_Bcells_Human1.82718155
19NANOG_20526341_ChIP-Seq_ESCs_Human1.82046405
20EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.81355824
21RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.80857661
22* RAC3_21632823_ChIP-Seq_H3396_Human1.76790191
23EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.73253061
24WDR5_24793694_ChIP-Seq_LNCAP_Human1.71087531
25BCL6_27268052_Chip-Seq_Bcells_Human1.67739561
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67048132
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65236589
28SMC4_20622854_ChIP-Seq_HELA_Human1.61740087
29YY1_22570637_ChIP-Seq_MALME-3M_Human1.61081360
30TAF2_19829295_ChIP-Seq_ESCs_Human1.60269983
31TDRD3_21172665_ChIP-Seq_MCF-7_Human1.58338142
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57816124
33BCOR_27268052_Chip-Seq_Bcells_Human1.56898503
34E2F1_20622854_ChIP-Seq_HELA_Human1.53433105
35P68_20966046_ChIP-Seq_HELA_Human1.52779639
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.52472903
37MYC_19829295_ChIP-Seq_ESCs_Human1.52230832
38ER_23166858_ChIP-Seq_MCF-7_Human1.51302924
39PHF8_20622854_ChIP-Seq_HELA_Human1.50969286
40OCT4_20526341_ChIP-Seq_ESCs_Human1.48947624
41SMAD4_21741376_ChIP-Seq_EPCs_Human1.48488461
42CTCF_20526341_ChIP-Seq_ESCs_Human1.47176232
43AUTS2_25519132_ChIP-Seq_293T-REX_Human1.46914667
44TP63_22573176_ChIP-Seq_HFKS_Human1.45546218
45PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.43978292
46AR_25329375_ChIP-Seq_VCAP_Human1.43399077
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42968959
48ERG_20517297_ChIP-Seq_VCAP_Human1.42690088
49LXR_22292898_ChIP-Seq_THP-1_Human1.41568923
50HNFA_21074721_ChIP-Seq_CACO-2_Human1.37689871
51CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.36076102
52P300_27268052_Chip-Seq_Bcells_Human1.35725687
53ETV2_25802403_ChIP-Seq_MESCs_Mouse1.34760316
54EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31994606
55ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31924924
56TP53_18474530_ChIP-ChIP_U2OS_Human1.31387665
57ETV1_20927104_ChIP-Seq_GIST48_Human1.30447099
58SMAD3_21741376_ChIP-Seq_ESCs_Human1.29350399
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29067327
60* RBPJ_21746931_ChIP-Seq_IB4_Human1.28053405
61* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27721323
62P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.27692196
63* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.27235702
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.25666388
65SOX2_22085726_ChIP-Seq_NPCs_Mouse1.25598906
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.25402446
67SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.25266253
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25004868
69KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.24285781
70NFYB_21822215_ChIP-Seq_K562_Human1.20938172
71GATA3_21878914_ChIP-Seq_MCF-7_Human1.19500784
72RUNX1_26923725_Chip-Seq_HPCs_Mouse1.18920233
73TBL1_22424771_ChIP-Seq_293T_Human1.18070242
74P300_19829295_ChIP-Seq_ESCs_Human1.17980796
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.17712009
76* CEBPB_22108803_ChIP-Seq_LS180_Human1.13893440
77PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13022179
78RUNX_20019798_ChIP-Seq_JUKART_Human1.13021187
79SMRT_27268052_Chip-Seq_Bcells_Human1.12421771
80P53_21459846_ChIP-Seq_SAOS-2_Human1.12219339
81PHF8_20622853_ChIP-Seq_HELA_Human1.12092661
82ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10694072
83GATA6_21074721_ChIP-Seq_CACO-2_Human1.10319291
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09329348
85SA1_27219007_Chip-Seq_Bcells_Human1.08937042
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05709413
87EZH2_27294783_Chip-Seq_ESCs_Mouse1.05235463
88NFYA_21822215_ChIP-Seq_K562_Human1.02732655
89TAF15_26573619_Chip-Seq_HEK293_Human1.02284756
90SMAD4_21799915_ChIP-Seq_A2780_Human1.02235937
91OCT1_27270436_Chip-Seq_PROSTATE_Human1.02078931
92PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.01432184
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01396777
94RUNX2_22187159_ChIP-Seq_PCA_Human1.00673054
95NANOG_19829295_ChIP-Seq_ESCs_Human1.00489945
96SOX2_19829295_ChIP-Seq_ESCs_Human1.00489945
97GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00368771
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00120527
99NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98900141
100* SMAD4_21741376_ChIP-Seq_HESCs_Human0.97633783

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.17857030
2MP0003878_abnormal_ear_physiology5.17857030
3MP0005670_abnormal_white_adipose5.09641049
4MP0003698_abnormal_male_reproductive4.63917663
5MP0001929_abnormal_gametogenesis4.06105561
6MP0001348_abnormal_lacrimal_gland3.30268984
7MP0002161_abnormal_fertility/fecundity2.62490684
8MP0000678_abnormal_parathyroid_gland2.25650136
9MP0003718_maternal_effect2.14967115
10MP0003646_muscle_fatigue2.06482350
11MP0005410_abnormal_fertilization12.7434907
12MP0002210_abnormal_sex_determination1.86266772
13MP0002132_abnormal_respiratory_system1.79529313
14MP0003011_delayed_dark_adaptation1.76249144
15MP0005423_abnormal_somatic_nervous1.65659995
16MP0005379_endocrine/exocrine_gland_phen1.59851190
17MP0001485_abnormal_pinna_reflex1.59080702
18MP0001145_abnormal_male_reproductive1.52128429
19MP0000653_abnormal_sex_gland1.44582922
20MP0002234_abnormal_pharynx_morphology1.44114901
21MP0005310_abnormal_salivary_gland1.43148519
22MP0002249_abnormal_larynx_morphology1.41273685
23MP0001486_abnormal_startle_reflex1.39731275
24MP0002822_catalepsy1.39046575
25MP0005451_abnormal_body_composition1.32884005
26MP0009053_abnormal_anal_canal1.31671860
27MP0002282_abnormal_trachea_morphology1.30578964
28MP0004859_abnormal_synaptic_plasticity1.23465763
29MP0003879_abnormal_hair_cell1.22384854
30MP0000534_abnormal_ureter_morphology1.16988325
31MP0002138_abnormal_hepatobiliary_system1.14541706
32MP0001765_abnormal_ion_homeostasis1.14396880
33MP0004742_abnormal_vestibular_system1.14374028
34MP0002735_abnormal_chemical_nociception1.11406529
35MP0001963_abnormal_hearing_physiology1.07408736
36MP0002127_abnormal_cardiovascular_syste0.98570380
37MP0009115_abnormal_fat_cell0.98209663
38MP0001968_abnormal_touch/_nociception0.97887336
39MP0005395_other_phenotype0.97640607
40MP0004510_myositis0.95288199
41MP0005666_abnormal_adipose_tissue0.91903982
42MP0005248_abnormal_Harderian_gland0.91343260
43MP0000026_abnormal_inner_ear0.90745046
44MP0000955_abnormal_spinal_cord0.85806143
45MP0002229_neurodegeneration0.84187553
46MP0008569_lethality_at_weaning0.80457531
47MP0005551_abnormal_eye_electrophysiolog0.80437371
48MP0008877_abnormal_DNA_methylation0.76680656
49MP0001905_abnormal_dopamine_level0.73597399
50MP0005083_abnormal_biliary_tract0.72946018
51MP0002067_abnormal_sensory_capabilities0.72803842
52MP0005375_adipose_tissue_phenotype0.71465128
53MP0000681_abnormal_thyroid_gland0.71055408
54MP0002557_abnormal_social/conspecific_i0.68695364
55MP0005253_abnormal_eye_physiology0.68233770
56MP0009697_abnormal_copulation0.66018249
57MP0000049_abnormal_middle_ear0.63636189
58MP0004085_abnormal_heartbeat0.62723696
59MP0005636_abnormal_mineral_homeostasis0.58003539
60MP0001879_abnormal_lymphatic_vessel0.57274924
61MP0005167_abnormal_blood-brain_barrier0.56742998
62MP0002733_abnormal_thermal_nociception0.56274800
63MP0000516_abnormal_urinary_system0.52638847
64MP0005367_renal/urinary_system_phenotyp0.52638847
65MP0001666_abnormal_nutrient_absorption0.52272083
66MP0000003_abnormal_adipose_tissue0.52264457
67MP0003077_abnormal_cell_cycle0.52243564
68MP0002572_abnormal_emotion/affect_behav0.51955491
69MP0004484_altered_response_of0.51255540
70MP0002272_abnormal_nervous_system0.50036713
71MP0001440_abnormal_grooming_behavior0.48388698
72MP0004036_abnormal_muscle_relaxation0.46873443
73MP0009745_abnormal_behavioral_response0.46301919
74MP0001984_abnormal_olfaction0.45477063
75MP0004233_abnormal_muscle_weight0.45416724
76MP0003699_abnormal_female_reproductive0.45271377
77MP0008995_early_reproductive_senescence0.44623394
78MP0005535_abnormal_body_temperature0.44435502
79MP0001501_abnormal_sleep_pattern0.41819421
80MP0008961_abnormal_basal_metabolism0.41589242
81MP0003631_nervous_system_phenotype0.41197232
82MP0003137_abnormal_impulse_conducting0.40478528
83MP0010329_abnormal_lipoprotein_level0.40263125
84MP0001270_distended_abdomen0.40207974
85MP0000613_abnormal_salivary_gland0.40010650
86MP0002734_abnormal_mechanical_nocicepti0.39331039
87MP0000249_abnormal_blood_vessel0.39142293
88MP0000470_abnormal_stomach_morphology0.39011634
89MP0005084_abnormal_gallbladder_morpholo0.38996988
90MP0001970_abnormal_pain_threshold0.38809071
91MP0005647_abnormal_sex_gland0.38647465
92MP0002928_abnormal_bile_duct0.38078440
93MP0005623_abnormal_meninges_morphology0.36940468
94MP0005408_hypopigmentation0.36423232
95MP0000230_abnormal_systemic_arterial0.36363630
96MP0003091_abnormal_cell_migration0.34413458
97MP0003880_abnormal_central_pattern0.33953996
98MP0003632_abnormal_nervous_system0.33924838
99MP0003635_abnormal_synaptic_transmissio0.33300080
100MP0003119_abnormal_digestive_system0.32846925

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.07732964
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.13678861
3Absent/shortened dynein arms (HP:0200106)6.13678861
4Tubulointerstitial nephritis (HP:0001970)5.76395028
5Chronic hepatic failure (HP:0100626)5.31351734
6Asymmetric septal hypertrophy (HP:0001670)5.25844888
7Bony spicule pigmentary retinopathy (HP:0007737)4.98101062
8Attenuation of retinal blood vessels (HP:0007843)4.95731465
9Hyperkalemia (HP:0002153)4.83945881
10Resting tremor (HP:0002322)4.80840953
11Abnormal ciliary motility (HP:0012262)4.69248380
12Abnormal respiratory motile cilium physiology (HP:0012261)4.67453551
13Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.47370051
14Abnormal respiratory epithelium morphology (HP:0012253)4.45396555
15Abnormal respiratory motile cilium morphology (HP:0005938)4.45396555
16Infertility (HP:0000789)4.36903568
17Nasal polyposis (HP:0100582)4.36685195
18Male infertility (HP:0003251)4.33236762
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.29406187
20Abnormality of macular pigmentation (HP:0008002)4.25994039
21Cone-rod dystrophy (HP:0000548)4.07677536
22Bell-shaped thorax (HP:0001591)4.02711384
23Potter facies (HP:0002009)3.90414729
24Facial shape deformation (HP:0011334)3.90414729
25Abnormal rod and cone electroretinograms (HP:0008323)3.83882337
26Abnormality of the nasal mucosa (HP:0000433)3.56073196
27Hypoalphalipoproteinemia (HP:0003233)3.54970849
28Hypoplasia of the thymus (HP:0000778)3.53482972
29Aplasia/Hypoplasia of the earlobes (HP:0009906)3.52175191
30Progressive sensorineural hearing impairment (HP:0000408)3.40797427
31Impulsivity (HP:0100710)3.39824386
32Hypoplastic ischia (HP:0003175)3.29787272
33Abnormal spermatogenesis (HP:0008669)3.22954976
34Postural instability (HP:0002172)3.22929092
35Menstrual irregularities (HP:0000858)3.18447932
36Enlarged epiphyses (HP:0010580)3.16667763
37Azoospermia (HP:0000027)3.09471941
38Renovascular hypertension (HP:0100817)2.98387336
39Abnormality of the ischium (HP:0003174)2.96195440
40Truncal obesity (HP:0001956)2.92549707
41Rhinitis (HP:0012384)2.86932696
42Amelogenesis imperfecta (HP:0000705)2.82538551
43Insulin-resistant diabetes mellitus (HP:0000831)2.78720897
44Abnormal urine output (HP:0012590)2.74164690
45Progressive cerebellar ataxia (HP:0002073)2.70981999
46Unilateral renal agenesis (HP:0000122)2.70512322
47Portal hypertension (HP:0001409)2.69545344
48Nephronophthisis (HP:0000090)2.66512921
49Tubulointerstitial abnormality (HP:0001969)2.64811175
50Abnormality of potassium homeostasis (HP:0011042)2.64345382
51Generalized aminoaciduria (HP:0002909)2.63025138
52Abnormality of dental color (HP:0011073)2.62628636
53Stage 5 chronic kidney disease (HP:0003774)2.59033429
54Abnormality of the aortic arch (HP:0012303)2.56942537
55Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.55910888
56Double outlet right ventricle (HP:0001719)2.55375742
57Congenital malformation of the right heart (HP:0011723)2.55375742
58Renal dysplasia (HP:0000110)2.52118664
59Abnormality of the hepatic vasculature (HP:0006707)2.48348491
60Abnormality of the costochondral junction (HP:0000919)2.47256626
61Abnormality of renal excretion (HP:0011036)2.36746781
62Polydipsia (HP:0001959)2.33226223
63Abnormal drinking behavior (HP:0030082)2.33226223
64Hyperuricemia (HP:0002149)2.27119565
65Increased purine levels (HP:0004368)2.27119565
66Abnormality of the renal medulla (HP:0100957)2.25658879
67Chronic bronchitis (HP:0004469)2.19948569
68Progressive hearing impairment (HP:0001730)2.17171067
69Polyuria (HP:0000103)2.14271610
70Ventricular tachycardia (HP:0004756)2.14157544
71Flattened epiphyses (HP:0003071)2.12273871
72Abnormality of the parathyroid morphology (HP:0011766)2.11299698
73Myokymia (HP:0002411)2.11203396
74Bronchiectasis (HP:0002110)2.10109677
75Osteomalacia (HP:0002749)2.09257093
76Recurrent pneumonia (HP:0006532)2.02839274
77Widely patent fontanelles and sutures (HP:0004492)2.02283136
78Epiphyseal dysplasia (HP:0002656)1.96518278
79Hypophosphatemic rickets (HP:0004912)1.95276312
80Subcapsular cataract (HP:0000523)1.94187313
81Hyponatremia (HP:0002902)1.93286001
82Optic nerve hypoplasia (HP:0000609)1.85718928
83Abnormality of the epiphysis of the femoral head (HP:0010574)1.84922464
84Focal segmental glomerulosclerosis (HP:0000097)1.84608743
85Renal Fanconi syndrome (HP:0001994)1.81320620
86Intellectual disability, moderate (HP:0002342)1.80637064
87Decreased central vision (HP:0007663)1.79928775
88Tetany (HP:0001281)1.79286892
89Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.77075031
90Absent epiphyses (HP:0010577)1.77075031
91Aplasia/Hypoplasia of the sacrum (HP:0008517)1.74999456
92Bradycardia (HP:0001662)1.73922165
93Hypolipoproteinemia (HP:0010981)1.73146061
94Abnormal ventriculo-arterial connection (HP:0011563)1.72697503
95Transposition of the great arteries (HP:0001669)1.72697503
96Abnormal connection of the cardiac segments (HP:0011545)1.72697503
97Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.71900183
98Abnormality of femoral epiphyses (HP:0006499)1.71900183
99Neoplasm of the heart (HP:0100544)1.71479555
100Insulin resistance (HP:0000855)1.71207986

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.46753417
2TESK15.94448704
3DDR24.31132393
4STK383.83337993
5PNCK3.36301816
6INSRR3.35748506
7BRD43.31816763
8PLK23.10836720
9MAP4K23.02466783
10STK38L2.73592673
11PRKD32.73330151
12CAMK1G2.55563800
13MAPK152.44329594
14MST1R1.87553997
15PIK3CG1.72559865
16PDPK11.69355068
17PDK11.58166732
18NEK61.56480565
19DYRK1B1.50984868
20WNK11.45949940
21CDK121.38403234
22CDK71.17987492
23PTK2B1.10914992
24AKT31.07551035
25MAP3K91.00435709
26KSR20.99308181
27TYRO30.98538964
28SIK20.92439826
29CAMK1D0.87661597
30PRKG20.79293904
31BRAF0.78186478
32WNK40.74515473
33MAP3K110.72543853
34LATS20.69830723
35PRKG10.67568766
36RPS6KA20.66905060
37MAP2K20.66822833
38STK390.65487199
39RPS6KA10.62991304
40UHMK10.62213749
41CAMK10.58573019
42MAP3K20.58415835
43RIPK40.54604069
44PINK10.54024540
45ROCK10.53076221
46SGK2230.53042155
47SGK4940.53042155
48PRKAA20.51115736
49CDK30.50013315
50MAP3K80.49158949
51GSK3B0.46758918
52LATS10.46598403
53CDK20.46092912
54BMPR1B0.43304978
55MAPK10.41332135
56CDK10.40834392
57MAP3K10.39942895
58MTOR0.39642054
59MAPK80.37418911
60TIE10.34710170
61CDK40.33863853
62RPS6KL10.33252019
63RPS6KC10.33252019
64CAMK40.32998370
65SGK10.32300230
66TESK20.31022931
67MARK10.30715376
68PRKCZ0.30686944
69RPS6KA60.30259441
70ARAF0.28918103
71MET0.28056764
72PRKCG0.27432805
73CHEK10.26853714
74MUSK0.26285740
75NTRK30.25489769
76NEK20.24723112
77PRKCB0.23607422
78MAPK140.23584630
79MAPK100.21566419
80BRSK10.21428021
81MAP3K40.18881827
82MARK20.18182020
83MAPK110.16865961
84JAK30.16466311
85AKT10.14954289
86OXSR10.13959939
87MINK10.12646498
88SGK20.12090778
89PKN10.11414372
90BLK0.10264818
91FRK0.09315010
92TNIK0.09119920
93PRKACB0.09066881
94FER0.09005468
95PRKACA0.08644912
96PRKAA10.07365066
97MAP2K70.07055711
98RPS6KA30.05370878
99MAPK90.05264068
100PRKCQ0.04444551

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.54868742
2Fatty acid biosynthesis_Homo sapiens_hsa000617.27894347
3Olfactory transduction_Homo sapiens_hsa047403.48834998
4Butanoate metabolism_Homo sapiens_hsa006502.55063500
5Glycerophospholipid metabolism_Homo sapiens_hsa005642.16896003
6Fatty acid degradation_Homo sapiens_hsa000712.00279884
7Dorso-ventral axis formation_Homo sapiens_hsa043201.85088626
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.81741023
9Fatty acid metabolism_Homo sapiens_hsa012121.80423917
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.71267654
11Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.66111816
12Taste transduction_Homo sapiens_hsa047421.62106765
13Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.52058087
14Type II diabetes mellitus_Homo sapiens_hsa049301.50433787
15RNA transport_Homo sapiens_hsa030131.49314324
16Phenylalanine metabolism_Homo sapiens_hsa003601.44271654
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.42212669
18Adipocytokine signaling pathway_Homo sapiens_hsa049201.39133000
19Type I diabetes mellitus_Homo sapiens_hsa049401.31043198
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.24764774
21Antigen processing and presentation_Homo sapiens_hsa046121.19359176
22Allograft rejection_Homo sapiens_hsa053301.17520311
23Autoimmune thyroid disease_Homo sapiens_hsa053201.15406533
24PPAR signaling pathway_Homo sapiens_hsa033201.13373502
25Phototransduction_Homo sapiens_hsa047441.05792021
26Graft-versus-host disease_Homo sapiens_hsa053321.05252039
27Endocytosis_Homo sapiens_hsa041441.01323105
28Arginine and proline metabolism_Homo sapiens_hsa003301.00555767
29Salivary secretion_Homo sapiens_hsa049700.97987537
30Inositol phosphate metabolism_Homo sapiens_hsa005620.96092536
31Arginine biosynthesis_Homo sapiens_hsa002200.95338402
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95264244
33Hedgehog signaling pathway_Homo sapiens_hsa043400.93649477
34Protein digestion and absorption_Homo sapiens_hsa049740.93401016
35Morphine addiction_Homo sapiens_hsa050320.89582654
36Calcium signaling pathway_Homo sapiens_hsa040200.86716120
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86567948
38Viral myocarditis_Homo sapiens_hsa054160.85749000
39Synaptic vesicle cycle_Homo sapiens_hsa047210.85520179
40cAMP signaling pathway_Homo sapiens_hsa040240.83979802
41Circadian entrainment_Homo sapiens_hsa047130.82107992
42ABC transporters_Homo sapiens_hsa020100.78304143
43Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76706659
44Oocyte meiosis_Homo sapiens_hsa041140.73755895
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73037904
46Renin-angiotensin system_Homo sapiens_hsa046140.71751374
47Glycerolipid metabolism_Homo sapiens_hsa005610.71668435
48Selenocompound metabolism_Homo sapiens_hsa004500.71611453
49Estrogen signaling pathway_Homo sapiens_hsa049150.70305188
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69691626
51Fat digestion and absorption_Homo sapiens_hsa049750.68086933
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66825322
53Influenza A_Homo sapiens_hsa051640.66745073
54Nicotine addiction_Homo sapiens_hsa050330.66103690
55Cardiac muscle contraction_Homo sapiens_hsa042600.64087236
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64034978
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.62861642
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62728721
59Tyrosine metabolism_Homo sapiens_hsa003500.61947206
60Glutamatergic synapse_Homo sapiens_hsa047240.60100686
61Renin secretion_Homo sapiens_hsa049240.59821642
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58329820
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57625185
64Gastric acid secretion_Homo sapiens_hsa049710.52893752
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49965631
66MAPK signaling pathway_Homo sapiens_hsa040100.48878844
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.48326551
68VEGF signaling pathway_Homo sapiens_hsa043700.47672714
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.47526817
70Tight junction_Homo sapiens_hsa045300.46391455
71Bile secretion_Homo sapiens_hsa049760.45736008
72Serotonergic synapse_Homo sapiens_hsa047260.44530522
73Insulin secretion_Homo sapiens_hsa049110.43048417
74Long-term potentiation_Homo sapiens_hsa047200.42964490
75Retinol metabolism_Homo sapiens_hsa008300.42885576
76Purine metabolism_Homo sapiens_hsa002300.42798935
77Biosynthesis of amino acids_Homo sapiens_hsa012300.41871947
78Pancreatic secretion_Homo sapiens_hsa049720.41241626
79Nitrogen metabolism_Homo sapiens_hsa009100.41087319
80Acute myeloid leukemia_Homo sapiens_hsa052210.40700617
81Cholinergic synapse_Homo sapiens_hsa047250.38817075
82GABAergic synapse_Homo sapiens_hsa047270.34240749
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32071923
84Oxytocin signaling pathway_Homo sapiens_hsa049210.29891219
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26938518
86mRNA surveillance pathway_Homo sapiens_hsa030150.26544696
87Basal transcription factors_Homo sapiens_hsa030220.24060811
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.21174798
89Amphetamine addiction_Homo sapiens_hsa050310.20831101
90Prolactin signaling pathway_Homo sapiens_hsa049170.19706718
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19167821
92Viral carcinogenesis_Homo sapiens_hsa052030.19158077
93ECM-receptor interaction_Homo sapiens_hsa045120.18685079
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.17802345
95Alcoholism_Homo sapiens_hsa050340.16082452
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.14359879
97Fanconi anemia pathway_Homo sapiens_hsa034600.13798177
98Metabolic pathways_Homo sapiens_hsa011000.12519054
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.12491606
100Legionellosis_Homo sapiens_hsa051340.10284901

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