C2ORF54

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)9.46770718
2establishment of skin barrier (GO:0061436)9.19156232
3regulation of water loss via skin (GO:0033561)8.34681473
4peptide cross-linking (GO:0018149)7.42813004
5keratinocyte differentiation (GO:0030216)7.42785398
6multicellular organismal water homeostasis (GO:0050891)6.96133928
7epidermal cell differentiation (GO:0009913)6.00516137
8water homeostasis (GO:0030104)5.86613134
9bundle of His cell to Purkinje myocyte communication (GO:0086069)5.66185463
10cilium or flagellum-dependent cell motility (GO:0001539)5.39259645
11axonemal dynein complex assembly (GO:0070286)5.34380739
12epidermis development (GO:0008544)4.81998712
13molting cycle (GO:0042303)4.67159538
14hair cycle (GO:0042633)4.67159538
15primary alcohol catabolic process (GO:0034310)4.66361939
16keratinocyte proliferation (GO:0043616)4.65063149
17one-carbon compound transport (GO:0019755)4.27305421
18ethanol metabolic process (GO:0006067)4.25225804
19cilium movement (GO:0003341)4.21775341
20flavonoid metabolic process (GO:0009812)4.09195740
21transepithelial transport (GO:0070633)3.93866225
22intestinal epithelial cell development (GO:0060576)3.92432344
23keratinocyte development (GO:0003334)3.91869636
24cellular ketone body metabolic process (GO:0046950)3.90289528
25vitamin transmembrane transport (GO:0035461)3.86235267
26establishment of planar polarity (GO:0001736)3.74758842
27establishment of tissue polarity (GO:0007164)3.74758842
28sphingoid metabolic process (GO:0046519)3.72944302
29negative regulation of keratinocyte proliferation (GO:0010839)3.71404298
30apical protein localization (GO:0045176)3.67071829
31surfactant homeostasis (GO:0043129)3.66385584
32regulation of ruffle assembly (GO:1900027)3.66154003
33ectoderm development (GO:0007398)3.59400491
34motile cilium assembly (GO:0044458)3.49178955
35phenylpropanoid metabolic process (GO:0009698)3.48208830
36axoneme assembly (GO:0035082)3.43315986
37lung epithelium development (GO:0060428)3.43163883
38epithelial cilium movement (GO:0003351)3.38466555
39ketone body metabolic process (GO:1902224)3.37481790
40regulation of memory T cell differentiation (GO:0043380)3.30582930
41retinoic acid metabolic process (GO:0042573)3.29201533
42diol metabolic process (GO:0034311)3.26152552
43chemical homeostasis within a tissue (GO:0048875)3.24472763
44regulation of hippo signaling (GO:0035330)3.22079025
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.21892907
46ethanol oxidation (GO:0006069)3.17051747
47regulation of interleukin-5 production (GO:0032674)3.16464377
48retinol metabolic process (GO:0042572)3.15239429
49epoxygenase P450 pathway (GO:0019373)3.13358789
50sphingosine metabolic process (GO:0006670)3.08158526
51diterpenoid biosynthetic process (GO:0016102)3.06219870
52regulation of keratinocyte proliferation (GO:0010837)3.03832746
53glandular epithelial cell differentiation (GO:0002067)3.02311211
54regulation of interleukin-13 production (GO:0032656)3.02052519
55phosphatidylserine acyl-chain remodeling (GO:0036150)2.96231106
56gap junction assembly (GO:0016264)2.95413811
57primary alcohol metabolic process (GO:0034308)2.91266916
58cornea development in camera-type eye (GO:0061303)2.90660229
59phosphatidylinositol acyl-chain remodeling (GO:0036149)2.89305405
60linoleic acid metabolic process (GO:0043651)2.88514116
61exogenous drug catabolic process (GO:0042738)2.85544791
62polarized epithelial cell differentiation (GO:0030859)2.85238101
63long-chain fatty acid biosynthetic process (GO:0042759)2.84118545
64regulation of keratinocyte differentiation (GO:0045616)2.83103122
65excretion (GO:0007588)2.82330625
66O-glycan processing (GO:0016266)2.81699659
67asymmetric protein localization (GO:0008105)2.78203731
68phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.77901248
69drug catabolic process (GO:0042737)2.76845037
70calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.69790402
71lipoxygenase pathway (GO:0019372)2.66152208
72photoreceptor cell maintenance (GO:0045494)2.65698738
73drug metabolic process (GO:0017144)2.65043242
74regulation of cholesterol homeostasis (GO:2000188)2.64573388
75negative regulation of T cell differentiation in thymus (GO:0033085)2.57995601
76norepinephrine metabolic process (GO:0042415)2.57350798
77phospholipid efflux (GO:0033700)2.55722670
78phosphate ion homeostasis (GO:0055062)2.55571887
79trivalent inorganic anion homeostasis (GO:0072506)2.55571887
80establishment of apical/basal cell polarity (GO:0035089)2.55530709
81renal absorption (GO:0070293)2.53641590
82phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.50196595
83columnar/cuboidal epithelial cell development (GO:0002066)2.47461522
84protein autoprocessing (GO:0016540)2.47306918
85glutathione derivative biosynthetic process (GO:1901687)2.43439636
86glutathione derivative metabolic process (GO:1901685)2.43439636
87left/right axis specification (GO:0070986)2.42839122
88epithelium development (GO:0060429)2.41731247
89negative regulation of humoral immune response (GO:0002921)2.39864285
90indole-containing compound catabolic process (GO:0042436)2.39530958
91indolalkylamine catabolic process (GO:0046218)2.39530958
92tryptophan catabolic process (GO:0006569)2.39530958
93L-fucose catabolic process (GO:0042355)2.38530583
94fucose catabolic process (GO:0019317)2.38530583
95L-fucose metabolic process (GO:0042354)2.38530583
96L-ascorbic acid metabolic process (GO:0019852)2.38048070
97negative regulation of lipase activity (GO:0060192)2.37477691
98pyrimidine-containing compound transmembrane transport (GO:0072531)2.37171015
99sphingolipid biosynthetic process (GO:0030148)2.36301468
100keratinization (GO:0031424)12.7232255

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.79094813
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.73231396
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.31084638
4VDR_22108803_ChIP-Seq_LS180_Human3.22631495
5ESR1_20079471_ChIP-ChIP_T-47D_Human3.02877923
6ESR2_21235772_ChIP-Seq_MCF-7_Human2.91998727
7TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.58759861
8P63_26484246_Chip-Seq_KERATINOCYTES_Human2.57181742
9ZNF217_24962896_ChIP-Seq_MCF-7_Human2.52481385
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.31707851
11CDX2_20551321_ChIP-Seq_CACO-2_Human2.30761906
12AHR_22903824_ChIP-Seq_MCF-7_Human2.13891042
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.05055973
14ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.02136368
15FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.99817437
16* GATA4_25053715_ChIP-Seq_YYC3_Human1.85963384
17DROSHA_22980978_ChIP-Seq_HELA_Human1.81454555
18GATA3_24758297_ChIP-Seq_MCF-7_Human1.80528885
19ARNT_22903824_ChIP-Seq_MCF-7_Human1.72955797
20FOXO3_23340844_ChIP-Seq_DLD1_Human1.70556220
21TP63_23658742_ChIP-Seq_EP156T_Human1.66658572
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62388901
23FOXM1_26456572_ChIP-Seq_MCF-7_Human1.61809141
24SOX9_24532713_ChIP-Seq_HFSC_Mouse1.60772173
25SOX2_20726797_ChIP-Seq_SW620_Human1.60188169
26* RUNX1_27514584_Chip-Seq_MCF-7_Human1.60133839
27KLF5_25053715_ChIP-Seq_YYC3_Human1.58589916
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.57441691
29EGR1_23403033_ChIP-Seq_LIVER_Mouse1.53109953
30* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.49496989
31* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.49496989
32TP63_22573176_ChIP-Seq_HFKS_Human1.46299506
33FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.44862410
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43768437
35AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.42652137
36SOX2_27498859_Chip-Seq_STOMACH_Mouse1.42158803
37GATA6_25053715_ChIP-Seq_YYC3_Human1.40113557
38TCF4_18268006_ChIP-ChIP_LS174T_Human1.37914069
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.36672037
40NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.36241020
41LXR_22158963_ChIP-Seq_LIVER_Mouse1.33981800
42RXR_22158963_ChIP-Seq_LIVER_Mouse1.33061063
43PPARA_22158963_ChIP-Seq_LIVER_Mouse1.29712146
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27093001
45FOXA1_25552417_ChIP-Seq_VCAP_Human1.26488395
46RXR_22108803_ChIP-Seq_LS180_Human1.26461239
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25701036
48BCAT_22108803_ChIP-Seq_LS180_Human1.21882949
49PPAR_26484153_Chip-Seq_NCI-H1993_Human1.19791801
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18645748
51CEBPB_22108803_ChIP-Seq_LS180_Human1.15472159
52FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.14651708
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12880526
54OCT4_20526341_ChIP-Seq_ESCs_Human1.10575166
55* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09528499
56PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08925802
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07866433
58BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07001740
59FOXA2_19822575_ChIP-Seq_HepG2_Human1.06728217
60SMAD3_21741376_ChIP-Seq_HESCs_Human1.06373245
61TCF4_22108803_ChIP-Seq_LS180_Human1.06174730
62* RACK7_27058665_Chip-Seq_MCF-7_Human1.06120723
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05105436
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.05105436
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04858087
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04253050
67CTCF_27219007_Chip-Seq_Bcells_Human1.02670513
68OCT1_27270436_Chip-Seq_PROSTATE_Human1.02323799
69CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02054223
70SMC4_20622854_ChIP-Seq_HELA_Human1.01953786
71CJUN_26792858_Chip-Seq_BT549_Human1.01878352
72P53_21459846_ChIP-Seq_SAOS-2_Human1.01403118
73* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00954543
74ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00720975
75GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.99401985
76ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99205961
77ER_23166858_ChIP-Seq_MCF-7_Human0.98981015
78AR_25329375_ChIP-Seq_VCAP_Human0.98315790
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97883927
80TP53_18474530_ChIP-ChIP_U2OS_Human0.97655670
81ERG_20517297_ChIP-Seq_VCAP_Human0.96344450
82ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.95962849
83HTT_18923047_ChIP-ChIP_STHdh_Human0.94179477
84GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.94084339
85CDX2_22108803_ChIP-Seq_LS180_Human0.93799548
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93088283
87ZNF274_21170338_ChIP-Seq_K562_Hela0.91993015
88AR_20517297_ChIP-Seq_VCAP_Human0.91359489
89SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91240248
90GATA6_21074721_ChIP-Seq_CACO-2_Human0.90931172
91FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.90912817
92JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89160420
93P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.88674482
94ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88585500
95STAT3_23295773_ChIP-Seq_U87_Human0.88470317
96SMAD4_21799915_ChIP-Seq_A2780_Human0.88368845
97* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87331446
98RBPJ_21746931_ChIP-Seq_IB4_Human0.86331900
99CTCF_20526341_ChIP-Seq_ESCs_Human0.86297572
100FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86082009

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle7.81626182
2MP0002796_impaired_skin_barrier6.51253893
3MP0004043_abnormal_pH_regulation3.93226577
4MP0010678_abnormal_skin_adnexa3.63709949
5MP0005501_abnormal_skin_physiology3.59576877
6MP0005377_hearing/vestibular/ear_phenot3.46523634
7MP0003878_abnormal_ear_physiology3.46523634
8MP0004264_abnormal_extraembryonic_tissu3.31734888
9MP0005275_abnormal_skin_tensile3.31034054
10MP0000383_abnormal_hair_follicle3.20305007
11MP0002098_abnormal_vibrissa_morphology2.94127499
12MP0000579_abnormal_nail_morphology2.76996598
13MP0008875_abnormal_xenobiotic_pharmacok2.71509655
14MP0000566_synostosis2.56702411
15MP0000467_abnormal_esophagus_morphology2.51295404
16MP0004782_abnormal_surfactant_physiolog2.49093798
17MP0009780_abnormal_chondrocyte_physiolo2.48367660
18MP0001216_abnormal_epidermal_layer2.34340517
19MP0003941_abnormal_skin_development2.30713230
20MP0010771_integument_phenotype2.12447200
21MP0003195_calcinosis2.06259836
22MP0000377_abnormal_hair_follicle2.00559255
23MP0003453_abnormal_keratinocyte_physiol1.89882288
24MP0000427_abnormal_hair_cycle1.83415406
25MP0005083_abnormal_biliary_tract1.82738052
26MP0004885_abnormal_endolymph1.74550885
27MP0004019_abnormal_vitamin_homeostasis1.61315530
28MP0003011_delayed_dark_adaptation1.60883726
29MP0002139_abnormal_hepatobiliary_system1.58926343
30MP0004381_abnormal_hair_follicle1.56716085
31MP0000647_abnormal_sebaceous_gland1.55695928
32MP0005365_abnormal_bile_salt1.52919563
33MP0002909_abnormal_adrenal_gland1.39563059
34MP0008004_abnormal_stomach_pH1.33700898
35MP0002060_abnormal_skin_morphology1.29148278
36MP0003191_abnormal_cellular_cholesterol1.23376302
37MP0005085_abnormal_gallbladder_physiolo1.21847392
38MP0009053_abnormal_anal_canal1.19926351
39MP0002095_abnormal_skin_pigmentation1.16814251
40MP0000762_abnormal_tongue_morphology1.15778880
41MP0001765_abnormal_ion_homeostasis1.14185353
42MP0000367_abnormal_coat/_hair1.13373411
43MP0002653_abnormal_ependyma_morphology1.11445807
44MP0009931_abnormal_skin_appearance1.11335703
45MP0001666_abnormal_nutrient_absorption1.10707845
46MP0000470_abnormal_stomach_morphology1.10025517
47MP0010352_gastrointestinal_tract_polyps1.07385775
48MP0005409_darkened_coat_color0.99875397
49MP0001485_abnormal_pinna_reflex0.98524408
50MP0009379_abnormal_foot_pigmentation0.97104895
51MP0002876_abnormal_thyroid_physiology0.96746774
52MP0005646_abnormal_pituitary_gland0.96570825
53MP0004947_skin_inflammation0.96425475
54MP0003638_abnormal_response/metabolism_0.96208905
55MP0009643_abnormal_urine_homeostasis0.96020276
56MP0003252_abnormal_bile_duct0.93986830
57MP0003950_abnormal_plasma_membrane0.93675686
58MP0005636_abnormal_mineral_homeostasis0.92059352
59MP0000678_abnormal_parathyroid_gland0.90442249
60MP0001188_hyperpigmentation0.87860055
61MP0000371_diluted_coat_color0.87059192
62MP0010329_abnormal_lipoprotein_level0.85242522
63MP0008872_abnormal_physiological_respon0.83091531
64MP0003879_abnormal_hair_cell0.81534901
65MP0002168_other_aberrant_phenotype0.80541334
66MP0000465_gastrointestinal_hemorrhage0.76253024
67MP0003045_fibrosis0.73153810
68MP0001984_abnormal_olfaction0.72577032
69MP0001756_abnormal_urination0.69340330
70MP0002118_abnormal_lipid_homeostasis0.69133940
71MP0001191_abnormal_skin_condition0.66939049
72MP0005551_abnormal_eye_electrophysiolog0.66884785
73MP0002249_abnormal_larynx_morphology0.65970831
74MP0001501_abnormal_sleep_pattern0.64430043
75MP0005360_urolithiasis0.61682186
76MP0010386_abnormal_urinary_bladder0.61442636
77MP0001243_abnormal_dermal_layer0.60905858
78MP0005332_abnormal_amino_acid0.60875790
79MP0003566_abnormal_cell_adhesion0.60157636
80MP0002138_abnormal_hepatobiliary_system0.56922864
81MP0001664_abnormal_digestion0.55684837
82MP0005395_other_phenotype0.54313298
83MP0002736_abnormal_nociception_after0.53534433
84MP0005670_abnormal_white_adipose0.52468909
85MP0001851_eye_inflammation0.52105339
86MP0001944_abnormal_pancreas_morphology0.49328596
87MP0001968_abnormal_touch/_nociception0.48476090
88MP0002234_abnormal_pharynx_morphology0.48442591
89MP0002136_abnormal_kidney_physiology0.47735726
90MP0002111_abnormal_tail_morphology0.47524187
91MP0005075_abnormal_melanosome_morpholog0.41946170
92MP0005367_renal/urinary_system_phenotyp0.41827286
93MP0000516_abnormal_urinary_system0.41827286
94MP0001764_abnormal_homeostasis0.40999159
95MP0002282_abnormal_trachea_morphology0.40291577
96MP0005220_abnormal_exocrine_pancreas0.40020722
97MP0003119_abnormal_digestive_system0.39908139
98MP0003943_abnormal_hepatobiliary_system0.38653024
99MP0003183_abnormal_peptide_metabolism0.38335244
100MP0005647_abnormal_sex_gland0.38002931

Predicted human phenotypes

RankGene SetZ-score
1Congenital ichthyosiform erythroderma (HP:0007431)6.27764488
2Abnormality of nail color (HP:0100643)6.04409358
3Palmoplantar hyperkeratosis (HP:0000972)5.76210412
4Oral leukoplakia (HP:0002745)5.61627599
5Erythroderma (HP:0001019)5.45738519
6Palmar hyperkeratosis (HP:0010765)5.41681784
7Increased IgE level (HP:0003212)5.25353246
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.07572431
9Plantar hyperkeratosis (HP:0007556)4.76446277
10Hypotrichosis (HP:0001006)4.68745620
11Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.62026879
12Chronic bronchitis (HP:0004469)4.52347430
13Abnormal respiratory motile cilium physiology (HP:0012261)4.50562178
14Dynein arm defect of respiratory motile cilia (HP:0012255)4.46618743
15Absent/shortened dynein arms (HP:0200106)4.46618743
16Abnormal ciliary motility (HP:0012262)4.40215210
17Abnormal respiratory motile cilium morphology (HP:0005938)4.20661979
18Abnormal respiratory epithelium morphology (HP:0012253)4.20661979
19Right ventricular cardiomyopathy (HP:0011663)4.17361233
20Alopecia of scalp (HP:0002293)4.06316736
21Rhinitis (HP:0012384)4.05869205
22Erythema (HP:0010783)3.93238566
23Lip pit (HP:0100267)3.84161149
24Corneal erosion (HP:0200020)3.72332362
25Hyperactive renin-angiotensin system (HP:0000841)3.52910090
26Fragile nails (HP:0001808)3.36625511
27Onycholysis (HP:0001806)3.28884390
28Parakeratosis (HP:0001036)3.25170531
29Woolly hair (HP:0002224)3.24023805
30Pili torti (HP:0003777)3.23662882
31Thick nail (HP:0001805)3.18381021
32Bronchiectasis (HP:0002110)3.11052977
33Abnormality of the axillary hair (HP:0100134)3.07523109
34Abnormality of secondary sexual hair (HP:0009888)3.07523109
35Abnormal hair laboratory examination (HP:0003328)3.04843187
36Furrowed tongue (HP:0000221)2.97813033
37Absent eyelashes (HP:0000561)2.93913307
38Nasal polyposis (HP:0100582)2.92579508
39Amelogenesis imperfecta (HP:0000705)2.91835968
40Hypohidrosis (HP:0000966)2.72976017
41Ectropion (HP:0000656)2.68461613
42Hyperkalemia (HP:0002153)2.61907160
43Pustule (HP:0200039)2.56434387
44Palmoplantar keratoderma (HP:0000982)2.47493098
45Nail dystrophy (HP:0008404)2.46623097
46Brittle hair (HP:0002299)2.44934258
47Abnormality of the salivary glands (HP:0010286)2.42188831
48Abnormality of monocarboxylic acid metabolism (HP:0010996)2.39144002
49Dehydration (HP:0001944)2.38946021
50Genetic anticipation (HP:0003743)2.36601091
51Hypoplastic labia majora (HP:0000059)2.34717778
52Dysmetric saccades (HP:0000641)2.32732482
53Gangrene (HP:0100758)2.32066657
54Sparse eyelashes (HP:0000653)2.29130362
55Renal salt wasting (HP:0000127)2.28467525
56Decreased circulating renin level (HP:0003351)2.28405171
57Absent hair (HP:0002298)2.28082244
58Popliteal pterygium (HP:0009756)2.25978638
59Abnormality of the nasal mucosa (HP:0000433)2.23596301
60Sparse scalp hair (HP:0002209)2.21894152
61Abnormality of renin-angiotensin system (HP:0000847)2.17657389
62Pruritus (HP:0000989)2.16652128
63Tubular atrophy (HP:0000092)2.14740684
64Abnormality of the labia majora (HP:0012881)2.14389180
65Conjunctival hamartoma (HP:0100780)2.12986988
66Curly hair (HP:0002212)2.12483487
67Gaze-evoked nystagmus (HP:0000640)2.09296935
68Acanthosis nigricans (HP:0000956)2.08250990
69Abnormality of chloride homeostasis (HP:0011422)2.05053123
70Abnormality of the dental root (HP:0006486)1.99065344
71Taurodontia (HP:0000679)1.99065344
72Abnormality of permanent molar morphology (HP:0011071)1.99065344
73Abnormality of macular pigmentation (HP:0008002)1.95647196
74Hyperaldosteronism (HP:0000859)1.94167175
75Hamartoma of the eye (HP:0010568)1.94115731
76Intrahepatic cholestasis (HP:0001406)1.93592743
77Tubulointerstitial nephritis (HP:0001970)1.93164712
78Bronchitis (HP:0012387)1.88122918
79Villous atrophy (HP:0011473)1.87108722
80Abnormality of small intestinal villus morphology (HP:0011472)1.87108722
81Abnormality of the dental pulp (HP:0006479)1.86631561
82Abnormality of molar (HP:0011077)1.82988343
83Abnormality of molar morphology (HP:0011070)1.82988343
84Ketoacidosis (HP:0001993)1.82840937
85Pancreatic cysts (HP:0001737)1.78547184
86Blepharitis (HP:0000498)1.77979762
87True hermaphroditism (HP:0010459)1.74461921
88Abnormal blistering of the skin (HP:0008066)1.73886478
89Progressive cerebellar ataxia (HP:0002073)1.73734205
90Oligodontia (HP:0000677)1.73163409
91Vascular calcification (HP:0004934)1.69688118
92Abnormality of the renal cortex (HP:0011035)1.68908516
93Lack of skin elasticity (HP:0100679)1.67847638
94Cystic liver disease (HP:0006706)1.65914707
95Hydroxyprolinuria (HP:0003080)1.63661422
96Abnormality of proline metabolism (HP:0010907)1.63661422
97Hypokalemic alkalosis (HP:0001949)1.62465510
98Fair hair (HP:0002286)1.61540541
99Ependymoma (HP:0002888)1.60470206
100Pendular nystagmus (HP:0012043)1.58056454

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA27.41487582
2FRK5.12283026
3LATS13.88287853
4MST1R3.20661487
5STK38L3.06616454
6FER2.62002667
7MAP3K22.57356134
8MAPK152.55371746
9MST42.52548544
10NME12.49805837
11MAPKAPK32.25264493
12OXSR11.73166352
13INSRR1.68298739
14MAP3K61.67499524
15ADRBK21.66272063
16STK241.64671930
17MET1.60121589
18MATK1.59179041
19STK31.52872491
20MAP3K71.51199430
21MAP3K31.45106584
22TRPM71.43118535
23STK381.42393923
24GRK11.40299088
25PRKCI1.34135324
26WNK41.33742873
27RPS6KB21.32525250
28MAP3K121.28773528
29STK391.21460332
30TGFBR11.18657377
31MAP2K61.17951674
32ACVR1B1.15595294
33ERBB21.02977905
34BMPR1B1.00903662
35EPHA31.00763702
36IRAK10.98653151
37ERBB30.96129103
38PTK20.95108436
39WNK30.94247403
40PKN20.94239728
41SIK10.93869185
42BCR0.90335182
43GRK60.87421891
44MAP2K10.87002816
45CASK0.86865853
46FGFR30.85976046
47FGFR40.83812993
48LATS20.82324246
49PRKAA20.78495156
50MAP2K20.75242426
51ADRBK10.73048320
52CDK120.71101082
53TRIB30.70431799
54PRKCE0.69447435
55MAP4K20.69398003
56EPHB10.65506176
57FGFR10.63505596
58NTRK30.60316644
59CDK190.56087020
60CHUK0.53715897
61EEF2K0.53105903
62MAP3K40.48379959
63PTK2B0.46506864
64TAOK10.45105111
65MYLK0.44992901
66TNK20.44473347
67HIPK20.42469607
68RET0.41493499
69PDPK10.39140428
70PASK0.36731572
71MARK20.36467976
72RIPK10.35050994
73ERN10.33802908
74IKBKB0.32754524
75MAPK110.32025859
76PBK0.31868923
77SMG10.31143181
78PINK10.30081407
79TESK10.29823424
80DAPK20.29807054
81NEK60.29008849
82CSNK1A10.27794126
83MAP3K90.27084828
84MAPKAPK50.26835055
85PRKCA0.24492007
86MAP2K70.24437020
87ABL10.23616487
88TAOK30.23358346
89IGF1R0.22931900
90IRAK30.22488570
91MAPKAPK20.22427813
92MAP2K40.22396912
93FGFR20.19894182
94TBK10.19876342
95MELK0.19549781
96SGK10.19227218
97LRRK20.18833927
98PRKAA10.18770463
99CAMK2A0.17439963
100ABL20.16749900

Predicted pathways (KEGG)

RankGene SetZ-score
1Histidine metabolism_Homo sapiens_hsa003403.08628188
2Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.00565936
3Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.96530301
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.79509941
5Steroid hormone biosynthesis_Homo sapiens_hsa001402.71127967
6Chemical carcinogenesis_Homo sapiens_hsa052042.70578032
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.68605068
8Linoleic acid metabolism_Homo sapiens_hsa005912.64174550
9Retinol metabolism_Homo sapiens_hsa008302.64001044
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.47590313
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.46273484
12Phenylalanine metabolism_Homo sapiens_hsa003602.43175543
13Sphingolipid metabolism_Homo sapiens_hsa006002.36532468
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.35159389
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.22092253
16Butanoate metabolism_Homo sapiens_hsa006502.15554425
17Cyanoamino acid metabolism_Homo sapiens_hsa004602.14170881
18ABC transporters_Homo sapiens_hsa020102.08867275
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.99369127
20Tyrosine metabolism_Homo sapiens_hsa003501.92841955
21beta-Alanine metabolism_Homo sapiens_hsa004101.92698369
22Arachidonic acid metabolism_Homo sapiens_hsa005901.85072548
23Tryptophan metabolism_Homo sapiens_hsa003801.73285101
24Ether lipid metabolism_Homo sapiens_hsa005651.62591104
25Fatty acid degradation_Homo sapiens_hsa000711.53957896
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46599512
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44832552
28Caffeine metabolism_Homo sapiens_hsa002321.36794376
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.36172175
30Phototransduction_Homo sapiens_hsa047441.33232159
31Starch and sucrose metabolism_Homo sapiens_hsa005001.32925591
32Ovarian steroidogenesis_Homo sapiens_hsa049131.28957334
33PPAR signaling pathway_Homo sapiens_hsa033201.12003698
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08895400
35Arginine biosynthesis_Homo sapiens_hsa002201.08662231
36Fat digestion and absorption_Homo sapiens_hsa049751.00181300
37Glutathione metabolism_Homo sapiens_hsa004800.99424928
38Glycerophospholipid metabolism_Homo sapiens_hsa005640.95886767
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94527821
40Vitamin digestion and absorption_Homo sapiens_hsa049770.94071111
41Taste transduction_Homo sapiens_hsa047420.93033062
42Salivary secretion_Homo sapiens_hsa049700.92995156
43Glycerolipid metabolism_Homo sapiens_hsa005610.92032046
44Complement and coagulation cascades_Homo sapiens_hsa046100.91910190
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91855487
46Tight junction_Homo sapiens_hsa045300.90952139
47Circadian rhythm_Homo sapiens_hsa047100.86198635
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85834596
49Arginine and proline metabolism_Homo sapiens_hsa003300.81982982
50Bile secretion_Homo sapiens_hsa049760.77958020
51Peroxisome_Homo sapiens_hsa041460.75947761
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75888285
53Nitrogen metabolism_Homo sapiens_hsa009100.75883350
54Fatty acid metabolism_Homo sapiens_hsa012120.74248061
55Collecting duct acid secretion_Homo sapiens_hsa049660.72941801
56Fatty acid elongation_Homo sapiens_hsa000620.71161468
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70262227
58Pancreatic secretion_Homo sapiens_hsa049720.68635526
59Serotonergic synapse_Homo sapiens_hsa047260.66990233
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63438027
61Sulfur metabolism_Homo sapiens_hsa009200.63038526
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62683046
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62052885
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61711193
65Fatty acid biosynthesis_Homo sapiens_hsa000610.59269060
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.55978109
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54548716
68N-Glycan biosynthesis_Homo sapiens_hsa005100.54353857
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51881250
70Steroid biosynthesis_Homo sapiens_hsa001000.51599916
71Metabolic pathways_Homo sapiens_hsa011000.51453996
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47279177
73Mineral absorption_Homo sapiens_hsa049780.47273276
74Choline metabolism in cancer_Homo sapiens_hsa052310.44394028
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41088847
76Long-term depression_Homo sapiens_hsa047300.40169319
77Insulin resistance_Homo sapiens_hsa049310.39731368
78Dorso-ventral axis formation_Homo sapiens_hsa043200.39291400
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38370328
80Propanoate metabolism_Homo sapiens_hsa006400.36947053
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.35864971
82Glutamatergic synapse_Homo sapiens_hsa047240.35057173
83Vibrio cholerae infection_Homo sapiens_hsa051100.33654352
84Olfactory transduction_Homo sapiens_hsa047400.31604183
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31552393
86Insulin secretion_Homo sapiens_hsa049110.30586291
87Hippo signaling pathway_Homo sapiens_hsa043900.30377600
88Hepatitis C_Homo sapiens_hsa051600.29490134
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.29160629
90Adherens junction_Homo sapiens_hsa045200.28443695
91GnRH signaling pathway_Homo sapiens_hsa049120.28331904
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27758806
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26777646
94Axon guidance_Homo sapiens_hsa043600.25983718
95Lysine degradation_Homo sapiens_hsa003100.25686938
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25126915
97Lysosome_Homo sapiens_hsa041420.24168701
98Circadian entrainment_Homo sapiens_hsa047130.23079957
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.21309394
100Calcium signaling pathway_Homo sapiens_hsa040200.21135776

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