C2ORF40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)9.42610007
2left/right pattern formation (GO:0060972)8.57831961
3regulation of cilium movement (GO:0003352)7.21258054
4primary alcohol catabolic process (GO:0034310)7.19350017
5left/right axis specification (GO:0070986)6.63452966
6ventricular system development (GO:0021591)6.27109654
7ethanol metabolic process (GO:0006067)5.99336445
8vitamin transmembrane transport (GO:0035461)5.90468802
9microtubule bundle formation (GO:0001578)5.82290575
10intraciliary transport (GO:0042073)5.55803046
11cilium organization (GO:0044782)5.27014024
12one-carbon compound transport (GO:0019755)5.13451769
13cilium assembly (GO:0042384)5.09108524
14diterpenoid biosynthetic process (GO:0016102)5.08631429
15negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)5.06188610
16ethanol oxidation (GO:0006069)4.73590740
17glomerular epithelial cell development (GO:0072310)4.59403558
18sperm capacitation (GO:0048240)4.55026554
19lung epithelium development (GO:0060428)4.37506236
20keratan sulfate catabolic process (GO:0042340)4.35461977
21centriole assembly (GO:0098534)4.31151946
22regulation of microtubule-based movement (GO:0060632)4.26774832
23protein localization to cilium (GO:0061512)4.26386348
24response to xenobiotic stimulus (GO:0009410)4.25077884
25pyrimidine-containing compound transmembrane transport (GO:0072531)4.22521519
26tolerance induction (GO:0002507)4.21511138
27negative regulation of T cell differentiation in thymus (GO:0033085)4.14267481
28thyroid hormone generation (GO:0006590)4.14235977
29cellular component assembly involved in morphogenesis (GO:0010927)4.13890947
30negative regulation of humoral immune response (GO:0002921)4.11620626
31microtubule-based movement (GO:0007018)4.03629394
32regulation of interleukin-5 production (GO:0032674)3.99984683
33cilium morphogenesis (GO:0060271)3.93997719
34establishment of apical/basal cell polarity (GO:0035089)3.89003275
35negative regulation of inclusion body assembly (GO:0090084)3.86675881
36regulation of interleukin-13 production (GO:0032656)3.72445756
37cell projection assembly (GO:0030031)3.71941805
38negative regulation of B cell mediated immunity (GO:0002713)3.68391909
39negative regulation of immunoglobulin mediated immune response (GO:0002890)3.68391909
40retinoic acid metabolic process (GO:0042573)3.67395024
41regulation of germinal center formation (GO:0002634)3.60897736
42thyroid hormone metabolic process (GO:0042403)3.48495899
43regulation of inclusion body assembly (GO:0090083)3.47649231
44lateral ventricle development (GO:0021670)3.45903499
45positive regulation of tolerance induction (GO:0002645)3.44563076
46terpenoid biosynthetic process (GO:0016114)3.37939525
47establishment or maintenance of monopolar cell polarity (GO:0061339)3.34308225
48establishment of monopolar cell polarity (GO:0061162)3.34308225
49primary alcohol metabolic process (GO:0034308)3.29481378
50hydrogen peroxide biosynthetic process (GO:0050665)3.27727850
51microtubule polymerization or depolymerization (GO:0031109)3.22346592
52sperm motility (GO:0030317)3.20986872
53positive regulation of smoothened signaling pathway (GO:0045880)3.20703202
54retinol metabolic process (GO:0042572)3.20637091
55cytoplasmic microtubule organization (GO:0031122)3.20246305
56nucleoside diphosphate phosphorylation (GO:0006165)3.18576534
57glutathione derivative metabolic process (GO:1901685)3.13889498
58glutathione derivative biosynthetic process (GO:1901687)3.13889498
59hydrogen peroxide catabolic process (GO:0042744)3.08692429
60establishment of planar polarity (GO:0001736)3.06381507
61establishment of tissue polarity (GO:0007164)3.06381507
62microtubule depolymerization (GO:0007019)2.98406548
63peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.90772479
64reactive oxygen species biosynthetic process (GO:1903409)2.86685754
65O-glycan processing (GO:0016266)2.79740059
66exogenous drug catabolic process (GO:0042738)2.76545493
67multicellular organismal water homeostasis (GO:0050891)2.76026905
68embryonic camera-type eye development (GO:0031076)2.71416933
69carnitine metabolic process (GO:0009437)2.71218672
70regulation of apoptotic cell clearance (GO:2000425)2.70697216
71polyol transport (GO:0015791)2.69840616
72phenol-containing compound catabolic process (GO:0019336)2.65388250
73hydrogen peroxide metabolic process (GO:0042743)2.64285671
74keratan sulfate biosynthetic process (GO:0018146)2.59640068
75determination of left/right symmetry (GO:0007368)2.58385085
76aldehyde catabolic process (GO:0046185)2.57894752
77lateral sprouting from an epithelium (GO:0060601)2.57620057
78excretion (GO:0007588)2.55901440
79retinal rod cell development (GO:0046548)2.55563716
80oligosaccharide biosynthetic process (GO:0009312)2.55162065
81smoothened signaling pathway (GO:0007224)2.54696158
82extracellular fibril organization (GO:0043206)2.53088971
83phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.50026448
84determination of bilateral symmetry (GO:0009855)2.49619681
85metanephric mesenchyme development (GO:0072075)2.49170856
86regulation of tolerance induction (GO:0002643)2.47514264
87specification of symmetry (GO:0009799)2.46693022
88regulation of microtubule depolymerization (GO:0031114)2.46308999
89phosphatidylcholine biosynthetic process (GO:0006656)2.45754029
90apical protein localization (GO:0045176)2.45406253
91progesterone metabolic process (GO:0042448)2.41525966
92heart looping (GO:0001947)2.41486695
93regulation of autophagic vacuole assembly (GO:2000785)2.40564879
94regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.39961702
95axonemal dynein complex assembly (GO:0070286)19.2267115
96cilium or flagellum-dependent cell motility (GO:0001539)16.2645703
97cilium movement (GO:0003341)14.1468550
98motile cilium assembly (GO:0044458)13.2254718
99epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)12.7022461
100epithelial cilium movement (GO:0003351)12.1701391

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.55362132
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.50910360
3DROSHA_22980978_ChIP-Seq_HELA_Human3.44272555
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.75576523
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.73715285
6FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.43520335
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.38015544
8ESR2_21235772_ChIP-Seq_MCF-7_Human1.94553797
9SMC4_20622854_ChIP-Seq_HELA_Human1.83196324
10RAD21_21589869_ChIP-Seq_MESCs_Mouse1.79811181
11PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.76536399
12TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.68242767
13ESR1_21235772_ChIP-Seq_MCF-7_Human1.63361510
14ESR1_20079471_ChIP-ChIP_T-47D_Human1.62397314
15PIAS1_25552417_ChIP-Seq_VCAP_Human1.55333670
16STAT1_20625510_ChIP-Seq_HELA_Human1.55183187
17AHR_22903824_ChIP-Seq_MCF-7_Human1.51136127
18RUNX1_27514584_Chip-Seq_MCF-7_Human1.48034567
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.43995346
20CTCF_27219007_Chip-Seq_Bcells_Human1.41584813
21TP63_22573176_ChIP-Seq_HFKS_Human1.40108936
22ELF1_20517297_ChIP-Seq_JURKAT_Human1.40037096
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39132038
24SOX9_24532713_ChIP-Seq_HFSC_Mouse1.38260617
25SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.37927666
26FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.37586214
27ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.34292500
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.33314393
29P63_26484246_Chip-Seq_KERATINOCYTES_Human1.32903227
30ARNT_22903824_ChIP-Seq_MCF-7_Human1.30976877
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30252929
32TP53_18474530_ChIP-ChIP_U2OS_Human1.28628393
33SOX2_27498859_Chip-Seq_STOMACH_Mouse1.28331643
34KLF5_25053715_ChIP-Seq_YYC3_Human1.26814993
35CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25922032
36CLOCK_20551151_ChIP-Seq_293T_Human1.25705718
37ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24126141
38TP63_23658742_ChIP-Seq_EP156T_Human1.21072797
39AR_21572438_ChIP-Seq_LNCaP_Human1.19816423
40NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19459913
41TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19410956
42TDRD3_21172665_ChIP-Seq_MCF-7_Human1.18066862
43CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.17257006
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.16585495
45* ETV1_20927104_ChIP-Seq_GIST48_Human1.14480285
46CTCF_20526341_ChIP-Seq_ESCs_Human1.14274105
47P68_20966046_ChIP-Seq_HELA_Human1.13539004
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13189192
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12988550
50SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12751569
51AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.12522104
52PHF8_20622853_ChIP-Seq_HELA_Human1.12317669
53LXR_22292898_ChIP-Seq_THP-1_Human1.11879211
54HNFA_21074721_ChIP-Seq_CACO-2_Human1.09196519
55SOX2_20726797_ChIP-Seq_SW620_Human1.07546537
56* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.07340284
57SMRT_27268052_Chip-Seq_Bcells_Human1.03912474
58GATA1_19941826_ChIP-Seq_K562_Human1.03086443
59FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02933922
60SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02609577
61CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02354010
62SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02280816
63YY1_22570637_ChIP-Seq_MALME-3M_Human1.02069754
64VDR_22108803_ChIP-Seq_LS180_Human1.01769461
65JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01031602
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00291846
67EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98657600
68BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98416125
69TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97569444
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96708881
71MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96648150
72SMAD3_21741376_ChIP-Seq_HESCs_Human0.95117384
73EP300_21415370_ChIP-Seq_HL-1_Mouse0.94827053
74TBX20_22328084_ChIP-Seq_HEART_Mouse0.94599135
75TBX20_22080862_ChIP-Seq_HEART_Mouse0.94599135
76FOXA1_25552417_ChIP-Seq_VCAP_Human0.94447081
77GATA6_21074721_ChIP-Seq_CACO-2_Human0.93680627
78* RBPJ_21746931_ChIP-Seq_IB4_Human0.93515342
79RACK7_27058665_Chip-Seq_MCF-7_Human0.93283951
80CDX2_20551321_ChIP-Seq_CACO-2_Human0.92926106
81CREB1_26743006_Chip-Seq_LNCaP_Human0.92573047
82CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91993246
83SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91609343
84SA1_27219007_Chip-Seq_ERYTHROID_Human0.91434750
85KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91286498
86TBL1_22424771_ChIP-Seq_293T_Human0.90693665
87SA1_27219007_Chip-Seq_Bcells_Human0.90605692
88PHF8_20622854_ChIP-Seq_HELA_Human0.90322380
89WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89810003
90NFYA_21822215_ChIP-Seq_K562_Human0.89661158
91GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.89383711
92NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89072778
93* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.88670859
94FOXA2_19822575_ChIP-Seq_HepG2_Human0.88482018
95SOX2_21211035_ChIP-Seq_LN229_Human0.88355826
96EED_16625203_ChIP-ChIP_MESCs_Mouse0.88111349
97MYC_27129775_Chip-Seq_CORNEA_Mouse0.87206361
98NFYB_21822215_ChIP-Seq_K562_Human0.85664453
99SMC3_22415368_ChIP-Seq_MEFs_Mouse0.85278616
100SMAD4_21741376_ChIP-Seq_HESCs_Human0.83313751

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology5.71466033
2MP0008875_abnormal_xenobiotic_pharmacok5.60976531
3MP0002653_abnormal_ependyma_morphology5.45092420
4MP0002132_abnormal_respiratory_system4.05210613
5MP0004043_abnormal_pH_regulation3.65940842
6MP0001984_abnormal_olfaction3.46958088
7MP0005623_abnormal_meninges_morphology3.20244095
8MP0009780_abnormal_chondrocyte_physiolo3.13587956
9MP0000566_synostosis2.96826589
10MP0004133_heterotaxia2.61046429
11MP0005275_abnormal_skin_tensile2.58330867
12MP0005377_hearing/vestibular/ear_phenot2.52517715
13MP0003878_abnormal_ear_physiology2.52517715
14MP0002282_abnormal_trachea_morphology2.36069559
15MP0002277_abnormal_respiratory_mucosa2.27216915
16MP0008789_abnormal_olfactory_epithelium2.24881872
17MP0010030_abnormal_orbit_morphology2.17870698
18MP0004019_abnormal_vitamin_homeostasis2.12583262
19MP0000751_myopathy2.01152819
20MP0002249_abnormal_larynx_morphology2.00955565
21MP0002108_abnormal_muscle_morphology1.96495740
22MP0000681_abnormal_thyroid_gland1.91516259
23MP0002876_abnormal_thyroid_physiology1.82026393
24MP0002933_joint_inflammation1.68231869
25MP0002638_abnormal_pupillary_reflex1.65240578
26MP0000383_abnormal_hair_follicle1.58705577
27MP0002168_other_aberrant_phenotype1.55973459
28MP0005508_abnormal_skeleton_morphology1.51852141
29MP0005083_abnormal_biliary_tract1.39959673
30MP0000678_abnormal_parathyroid_gland1.36075057
31MP0005394_taste/olfaction_phenotype1.35870685
32MP0005499_abnormal_olfactory_system1.35870685
33MP0001879_abnormal_lymphatic_vessel1.27751348
34MP0001765_abnormal_ion_homeostasis1.27645385
35MP0003279_aneurysm1.24160734
36MP0010368_abnormal_lymphatic_system1.20955215
37MP0003646_muscle_fatigue1.19295201
38MP0010678_abnormal_skin_adnexa1.16997972
39MP0001485_abnormal_pinna_reflex1.10023997
40MP0005164_abnormal_response_to1.09927026
41MP0009379_abnormal_foot_pigmentation1.09658371
42MP0002909_abnormal_adrenal_gland1.05932538
43MP0005165_increased_susceptibility_to1.05630560
44MP0004883_abnormal_blood_vessel1.02085332
45MP0003329_amyloid_beta_deposits1.01131972
46MP0001958_emphysema0.97315703
47MP0000163_abnormal_cartilage_morphology0.94707642
48MP0002295_abnormal_pulmonary_circulatio0.90761208
49MP0002160_abnormal_reproductive_system0.89769766
50MP0002233_abnormal_nose_morphology0.87405528
51MP0003011_delayed_dark_adaptation0.86688813
52MP0005390_skeleton_phenotype0.84864194
53MP0002133_abnormal_respiratory_system0.84863144
54MP0005388_respiratory_system_phenotype0.84863144
55MP0005248_abnormal_Harderian_gland0.84519092
56MP0000049_abnormal_middle_ear0.83561273
57MP0005395_other_phenotype0.82240825
58MP0003656_abnormal_erythrocyte_physiolo0.80575118
59MP0005365_abnormal_bile_salt0.80404797
60MP0002932_abnormal_joint_morphology0.80124380
61MP0001502_abnormal_circadian_rhythm0.79977356
62MP0000026_abnormal_inner_ear0.77733616
63MP0009384_cardiac_valve_regurgitation0.76001178
64MP0000465_gastrointestinal_hemorrhage0.75858780
65MP0001299_abnormal_eye_distance/0.75472104
66MP0002734_abnormal_mechanical_nocicepti0.74132590
67MP0009643_abnormal_urine_homeostasis0.72880159
68MP0005023_abnormal_wound_healing0.72630682
69MP0005636_abnormal_mineral_homeostasis0.71020463
70MP0000249_abnormal_blood_vessel0.70970623
71MP0001346_abnormal_lacrimal_gland0.70094725
72MP0003698_abnormal_male_reproductive0.69884605
73MP0002896_abnormal_bone_mineralization0.65938101
74MP0002116_abnormal_craniofacial_bone0.65512722
75MP0002735_abnormal_chemical_nociception0.65275317
76MP0002115_abnormal_skeleton_extremities0.61117981
77MP0001963_abnormal_hearing_physiology0.60893751
78MP0002136_abnormal_kidney_physiology0.60224731
79MP0003724_increased_susceptibility_to0.59238283
80MP0004885_abnormal_endolymph0.57652236
81MP0009046_muscle_twitch0.57000005
82MP0001929_abnormal_gametogenesis0.56486974
83MP0006138_congestive_heart_failure0.55814343
84MP0005410_abnormal_fertilization0.55020182
85MP0001270_distended_abdomen0.53992055
86MP0005253_abnormal_eye_physiology0.53024267
87MP0005167_abnormal_blood-brain_barrier0.50705002
88MP0005551_abnormal_eye_electrophysiolog0.50307442
89MP0003938_abnormal_ear_development0.50003717
90MP0004782_abnormal_surfactant_physiolog0.49684767
91MP0001849_ear_inflammation0.47482720
92MP0003879_abnormal_hair_cell0.47391542
93MP0003942_abnormal_urinary_system0.47284298
94MP0008004_abnormal_stomach_pH0.45915384
95MP0002109_abnormal_limb_morphology0.45431484
96MP0002972_abnormal_cardiac_muscle0.45392317
97MP0001970_abnormal_pain_threshold0.45374369
98MP0002090_abnormal_vision0.45340994
99MP0003075_altered_response_to0.42625988
100MP0003950_abnormal_plasma_membrane0.41495863

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.85809432
2Chronic bronchitis (HP:0004469)7.59744245
3Bronchiectasis (HP:0002110)6.98562228
4Nasal polyposis (HP:0100582)6.71090920
5Abnormality of the nasal mucosa (HP:0000433)5.82815088
6Bronchitis (HP:0012387)4.36110413
7Infertility (HP:0000789)4.15888351
8Recurrent sinusitis (HP:0011108)4.14376104
9Chronic sinusitis (HP:0011109)4.06886740
10Male infertility (HP:0003251)3.76302672
11Recurrent otitis media (HP:0000403)3.71125936
12Occipital encephalocele (HP:0002085)3.58368647
13Atelectasis (HP:0100750)3.29618553
14True hermaphroditism (HP:0010459)3.25934923
15Pancreatic fibrosis (HP:0100732)3.20907236
16Hyperactive renin-angiotensin system (HP:0000841)2.98699594
17Cystic liver disease (HP:0006706)2.73625787
18Chronic otitis media (HP:0000389)2.66971769
19Molar tooth sign on MRI (HP:0002419)2.58555935
20Abnormality of midbrain morphology (HP:0002418)2.58555935
21Nephronophthisis (HP:0000090)2.56439458
22Pancreatic cysts (HP:0001737)2.43520393
23Chronic hepatic failure (HP:0100626)2.25788194
24Postaxial foot polydactyly (HP:0001830)2.22247903
25Bell-shaped thorax (HP:0001591)2.19804390
26Tubulointerstitial nephritis (HP:0001970)2.17188271
27Recurrent bronchitis (HP:0002837)2.13612155
28Abnormality of the renal medulla (HP:0100957)2.01872613
29Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.1753838
30Abnormal respiratory epithelium morphology (HP:0012253)10.7989310
31Abnormal respiratory motile cilium morphology (HP:0005938)10.7989310
32Abnormal respiratory motile cilium physiology (HP:0012261)10.6780421
33Abnormal ciliary motility (HP:0012262)10.5247190
34Dynein arm defect of respiratory motile cilia (HP:0012255)10.5064662
35Absent/shortened dynein arms (HP:0200106)10.5064662
36Congenital hepatic fibrosis (HP:0002612)1.92279484
37Absent frontal sinuses (HP:0002688)1.86711871
38Aplasia/Hypoplasia of the tongue (HP:0010295)1.86118003
39Hyperkalemia (HP:0002153)1.84538247
40Male pseudohermaphroditism (HP:0000037)1.79967405
41Anencephaly (HP:0002323)1.78874470
42Decreased circulating renin level (HP:0003351)1.76016096
43Medial flaring of the eyebrow (HP:0010747)1.74183661
44Renal salt wasting (HP:0000127)1.72177548
45Congenital primary aphakia (HP:0007707)1.68173561
46Gait imbalance (HP:0002141)1.65945906
47Carpal bone hypoplasia (HP:0001498)1.65422609
48Tubular atrophy (HP:0000092)1.64787493
49Muscle fiber splitting (HP:0003555)1.63636534
50Nephropathy (HP:0000112)1.60474883
51Obstructive sleep apnea (HP:0002870)1.56921513
52Epiphyseal dysplasia (HP:0002656)1.56327908
53Asplenia (HP:0001746)1.53418163
54Aplasia/Hypoplasia of the spleen (HP:0010451)1.53065401
55Hyperaldosteronism (HP:0000859)1.47406357
56Short femoral neck (HP:0100864)1.47378499
57Spinal cord compression (HP:0002176)1.46348707
58Postaxial hand polydactyly (HP:0001162)1.45895586
59Nephrogenic diabetes insipidus (HP:0009806)1.43236276
60Sclerocornea (HP:0000647)1.43029519
61Oculomotor apraxia (HP:0000657)1.40784102
62Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.38966809
63Abnormality of the dental root (HP:0006486)1.38135245
64Taurodontia (HP:0000679)1.38135245
65Abnormality of permanent molar morphology (HP:0011071)1.38135245
66Furrowed tongue (HP:0000221)1.35194355
67Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.34104983
68Abnormality of molar (HP:0011077)1.33645916
69Abnormality of molar morphology (HP:0011070)1.33645916
70Abnormality of renin-angiotensin system (HP:0000847)1.32921358
71Complement deficiency (HP:0004431)1.31752676
72Abnormality of chloride homeostasis (HP:0011422)1.31073339
73Short thorax (HP:0010306)1.28039822
74Stage 5 chronic kidney disease (HP:0003774)1.27572082
75Abnormality of the dental pulp (HP:0006479)1.26035099
76Short nail (HP:0001799)1.24636055
77Glucose intolerance (HP:0000833)1.23136007
78Tubulointerstitial abnormality (HP:0001969)1.22215552
79Hypokalemic alkalosis (HP:0001949)1.20724125
80Bifid scrotum (HP:0000048)1.20593145
81Median cleft lip (HP:0000161)1.20485892
82Ulnar deviation of the wrist (HP:0003049)1.19192974
83Vaginal atresia (HP:0000148)1.16986744
84Abnormality of the distal phalanges of the toes (HP:0010182)1.16894974
85Genital tract atresia (HP:0001827)1.15728363
86Poor coordination (HP:0002370)1.15618031
87Pulmonary artery stenosis (HP:0004415)1.11099996
88Abnormality of dentin (HP:0010299)1.10864003
89Beaking of vertebral bodies (HP:0004568)1.09834833
90Hyponatremia (HP:0002902)1.09600536
91Sleep apnea (HP:0010535)1.09272754
92Renal dysplasia (HP:0000110)1.08591514
93Small epiphyses (HP:0010585)1.07580427
94Hypoplasia of the odontoid process (HP:0003311)1.07498365
95Vascular tortuosity (HP:0004948)1.07235832
96Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.06817979
97Abnormality of the frontal sinuses (HP:0002687)1.06599406
98Cone-rod dystrophy (HP:0000548)1.05935311
99Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.05873961
100Preaxial hand polydactyly (HP:0001177)1.05241978

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.20687440
2MST44.18925524
3MAPKAPK32.62405972
4PTK2B2.18792111
5MAPK1511.6248862
6TESK11.87592267
7MAP3K21.82989806
8NME11.75340509
9MAP3K31.71128948
10PNCK1.68431163
11RIPK11.68007685
12SMG11.52566159
13STK241.48000950
14EPHB11.42201798
15EEF2K1.37822217
16CSK1.30439214
17TTK1.27745765
18MARK21.25862977
19MYLK1.24830391
20BCR1.22473961
21MAP3K71.19353635
22LRRK21.15087526
23EPHA31.14161639
24TRIB31.09494269
25TIE10.93593766
26TBK10.89332275
27STK380.88202844
28INSRR0.85891448
29PAK40.82820842
30ARAF0.80851199
31NLK0.80712049
32CAMKK10.78201208
33CAMK2G0.77329142
34ERBB20.75422804
35NEK60.75105426
36ERN10.74770222
37MUSK0.68795825
38TRPM70.67247348
39MST1R0.63501783
40PRKAA20.62915694
41HIPK20.59322034
42MAP3K60.57941928
43STK100.56119461
44ROCK20.55939138
45DYRK1B0.55727353
46PRKD30.53400326
47STK38L0.51672024
48SGK10.49945624
49TGFBR20.49712403
50RIPK40.49267979
51ILK0.49260054
52ROCK10.49209811
53MAP3K120.48472752
54TLK10.47942487
55STK160.47488392
56CDK120.45568556
57MAP2K20.45188295
58CDC42BPA0.45053608
59MET0.44285611
60PRKCI0.44123868
61PRKCD0.42639253
62PDPK10.40807591
63RPS6KA20.40575929
64PRKCQ0.40497011
65PRKACA0.39060714
66CAMKK20.34551367
67PRKD20.33816508
68ABL20.33501921
69RET0.32104865
70ADRBK10.31993077
71LATS10.31909619
72SGK2230.31855788
73SGK4940.31855788
74EPHA40.31681002
75PRKD10.30354189
76PRKG10.29567675
77CAMK2A0.29410514
78PRKCA0.29174790
79PRKCZ0.28958917
80DMPK0.28728841
81ERBB30.28699189
82PIM20.28381596
83PRKG20.27998328
84FER0.25531478
85MAPK130.25325086
86CAMK1G0.25055445
87UHMK10.23984166
88GRK10.23743568
89MAPKAPK50.23711422
90MAP3K40.23216410
91SRC0.22877074
92PINK10.21516171
93IRAK10.21389526
94MAP3K110.21278854
95TAOK10.21119613
96SGK20.21068089
97PAK10.21036619
98CAMK10.20406698
99FYN0.20250621
100OBSCN0.18896359

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.05691101
2Phenylalanine metabolism_Homo sapiens_hsa003604.73661758
3Histidine metabolism_Homo sapiens_hsa003404.24068937
4Chemical carcinogenesis_Homo sapiens_hsa052044.07594702
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.98102686
6Tyrosine metabolism_Homo sapiens_hsa003503.97468282
7beta-Alanine metabolism_Homo sapiens_hsa004102.78814520
8Glutathione metabolism_Homo sapiens_hsa004802.78160277
9Huntingtons disease_Homo sapiens_hsa050162.41925105
10Retinol metabolism_Homo sapiens_hsa008302.03489821
11Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.81598965
12Linoleic acid metabolism_Homo sapiens_hsa005911.76569812
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.71239208
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.62377767
15Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.59013774
16Caffeine metabolism_Homo sapiens_hsa002321.51510187
17Arachidonic acid metabolism_Homo sapiens_hsa005901.44532226
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42852613
19Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.40306604
20Tight junction_Homo sapiens_hsa045301.37231197
21Circadian rhythm_Homo sapiens_hsa047101.28785720
22Complement and coagulation cascades_Homo sapiens_hsa046101.28494399
23Fatty acid degradation_Homo sapiens_hsa000711.27421400
24ECM-receptor interaction_Homo sapiens_hsa045121.15400868
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13886492
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.12591492
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.07674410
28Salivary secretion_Homo sapiens_hsa049701.03680977
29Sphingolipid metabolism_Homo sapiens_hsa006000.98084165
30ABC transporters_Homo sapiens_hsa020100.91243891
31Peroxisome_Homo sapiens_hsa041460.87525622
32PPAR signaling pathway_Homo sapiens_hsa033200.87497325
33Thyroid hormone synthesis_Homo sapiens_hsa049180.84120192
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81434227
35Taste transduction_Homo sapiens_hsa047420.79876074
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79276931
37Autoimmune thyroid disease_Homo sapiens_hsa053200.78980324
38Notch signaling pathway_Homo sapiens_hsa043300.75272928
39Basal cell carcinoma_Homo sapiens_hsa052170.74831011
40Olfactory transduction_Homo sapiens_hsa047400.72545205
41Hedgehog signaling pathway_Homo sapiens_hsa043400.72493355
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71532294
43Phototransduction_Homo sapiens_hsa047440.68764919
44Cocaine addiction_Homo sapiens_hsa050300.67758597
45Staphylococcus aureus infection_Homo sapiens_hsa051500.67677672
46Glycerophospholipid metabolism_Homo sapiens_hsa005640.66189012
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65229483
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.63263054
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.59743057
50Malaria_Homo sapiens_hsa051440.59264407
51cAMP signaling pathway_Homo sapiens_hsa040240.58390242
52Dilated cardiomyopathy_Homo sapiens_hsa054140.57276113
53Gastric acid secretion_Homo sapiens_hsa049710.57155147
54Adherens junction_Homo sapiens_hsa045200.57010474
55Choline metabolism in cancer_Homo sapiens_hsa052310.55764027
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55340479
57Prion diseases_Homo sapiens_hsa050200.55037505
58Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54541632
59Arginine and proline metabolism_Homo sapiens_hsa003300.51960129
60Starch and sucrose metabolism_Homo sapiens_hsa005000.51220770
61Amoebiasis_Homo sapiens_hsa051460.50498481
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.49491196
63Cardiac muscle contraction_Homo sapiens_hsa042600.49487368
64Amphetamine addiction_Homo sapiens_hsa050310.49472291
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46510337
66Nicotine addiction_Homo sapiens_hsa050330.46342210
67Protein digestion and absorption_Homo sapiens_hsa049740.45333421
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42604111
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41005320
70Glycerolipid metabolism_Homo sapiens_hsa005610.38645741
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38606218
72Tryptophan metabolism_Homo sapiens_hsa003800.37234304
73Calcium signaling pathway_Homo sapiens_hsa040200.34252049
74Phagosome_Homo sapiens_hsa041450.33617524
75Bile secretion_Homo sapiens_hsa049760.33278466
76Axon guidance_Homo sapiens_hsa043600.32550919
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.32063006
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31465771
79Melanogenesis_Homo sapiens_hsa049160.30730206
80Focal adhesion_Homo sapiens_hsa045100.30561039
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29598252
82Pancreatic secretion_Homo sapiens_hsa049720.29016466
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.28351000
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28210478
85Serotonergic synapse_Homo sapiens_hsa047260.26272546
86Hematopoietic cell lineage_Homo sapiens_hsa046400.26205257
87Hippo signaling pathway_Homo sapiens_hsa043900.25659091
88Hepatitis C_Homo sapiens_hsa051600.25555682
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.24885718
90Collecting duct acid secretion_Homo sapiens_hsa049660.24234192
91Pertussis_Homo sapiens_hsa051330.21891164
92Renin secretion_Homo sapiens_hsa049240.21588976
93Nitrogen metabolism_Homo sapiens_hsa009100.21486139
94Oxytocin signaling pathway_Homo sapiens_hsa049210.20604156
95Metabolic pathways_Homo sapiens_hsa011000.20342800
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.19729033
97Wnt signaling pathway_Homo sapiens_hsa043100.19602013
98Pyruvate metabolism_Homo sapiens_hsa006200.19003262
99Ovarian steroidogenesis_Homo sapiens_hsa049130.18310791
100Endocytosis_Homo sapiens_hsa041440.18295047

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