C2CD4D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1high-density lipoprotein particle remodeling (GO:0034375)5.83986918
2thymic T cell selection (GO:0045061)5.68751351
3establishment of skin barrier (GO:0061436)5.59584539
4regulation of water loss via skin (GO:0033561)5.58923469
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.54571719
6positive regulation of natural killer cell differentiation (GO:0032825)5.53497124
7negative thymic T cell selection (GO:0045060)5.41602668
8reverse cholesterol transport (GO:0043691)5.41503481
9negative T cell selection (GO:0043383)5.37162631
10low-density lipoprotein particle remodeling (GO:0034374)5.31626074
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.29690569
12ethanol oxidation (GO:0006069)5.17184491
13ER overload response (GO:0006983)5.15657712
14negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.15193806
15regulation of cholesterol esterification (GO:0010872)5.12057880
16tryptophan catabolic process (GO:0006569)4.98887088
17indole-containing compound catabolic process (GO:0042436)4.98887088
18indolalkylamine catabolic process (GO:0046218)4.98887088
19phospholipid homeostasis (GO:0055091)4.97008458
20carnitine metabolic process (GO:0009437)4.91196759
21amino-acid betaine metabolic process (GO:0006577)4.71255984
22phospholipid efflux (GO:0033700)4.61016699
23positive thymic T cell selection (GO:0045059)4.60157816
24positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.57044496
25kynurenine metabolic process (GO:0070189)4.56809680
26blood vessel maturation (GO:0001955)4.55717700
27aromatic amino acid family catabolic process (GO:0009074)4.55185531
28protein-lipid complex remodeling (GO:0034368)4.54146677
29macromolecular complex remodeling (GO:0034367)4.54146677
30plasma lipoprotein particle remodeling (GO:0034369)4.54146677
31tryptophan metabolic process (GO:0006568)4.48399087
32antigen processing and presentation of endogenous antigen (GO:0019883)4.44137250
33daunorubicin metabolic process (GO:0044597)4.43902262
34polyketide metabolic process (GO:0030638)4.43902262
35doxorubicin metabolic process (GO:0044598)4.43902262
36response to gravity (GO:0009629)4.42656044
37response to pheromone (GO:0019236)4.39050203
38long-chain fatty acid biosynthetic process (GO:0042759)4.38842873
39linoleic acid metabolic process (GO:0043651)4.36944304
40triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.33312464
41L-phenylalanine catabolic process (GO:0006559)4.29690324
42erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.29690324
43homocysteine metabolic process (GO:0050667)4.26055438
44positive regulation of interleukin-4 production (GO:0032753)4.24922487
45T cell migration (GO:0072678)4.20550168
46tolerance induction (GO:0002507)4.20283522
47T cell selection (GO:0045058)4.12594950
48erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.12124756
49L-phenylalanine metabolic process (GO:0006558)4.12124756
50primary alcohol catabolic process (GO:0034310)4.09371374
51regulation of cholesterol biosynthetic process (GO:0045540)4.09280126
52antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.97958189
53regulation of interleukin-2 biosynthetic process (GO:0045076)3.95386733
54NIK/NF-kappaB signaling (GO:0038061)3.88757633
55endothelial cell chemotaxis (GO:0035767)3.87352603
56amine catabolic process (GO:0009310)3.86760538
57cellular biogenic amine catabolic process (GO:0042402)3.86760538
58dicarboxylic acid biosynthetic process (GO:0043650)3.83200148
59amyloid precursor protein metabolic process (GO:0042982)3.79630064
60valine metabolic process (GO:0006573)3.74463214
61regulation of natural killer cell differentiation (GO:0032823)3.72926170
62cellular glucuronidation (GO:0052695)3.71176250
63serine family amino acid catabolic process (GO:0009071)3.70941688
64positive regulation of cellular amide metabolic process (GO:0034250)3.69734655
65fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.68954267
66positive T cell selection (GO:0043368)3.67756642
67bile acid biosynthetic process (GO:0006699)3.65749165
68plasma lipoprotein particle organization (GO:0071827)3.65041430
69cellular response to interleukin-15 (GO:0071350)3.64982713
70regulation of interleukin-13 production (GO:0032656)3.63242019
71regulation of interleukin-4 production (GO:0032673)3.62818009
72cholesterol efflux (GO:0033344)3.55846840
73multicellular organismal water homeostasis (GO:0050891)3.55083859
74urea metabolic process (GO:0019627)3.49227753
75urea cycle (GO:0000050)3.49227753
76positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.48266666
77protein carboxylation (GO:0018214)3.47575639
78peptidyl-glutamic acid carboxylation (GO:0017187)3.47575639
79regulation of isotype switching to IgG isotypes (GO:0048302)3.44774484
80lipoxygenase pathway (GO:0019372)3.40541390
81regulation of defense response to virus by virus (GO:0050690)3.40474942
82CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.40343445
83leukocyte aggregation (GO:0070486)3.38699345
84regulation of gamma-delta T cell differentiation (GO:0045586)3.38392528
85retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.33533117
86purine ribonucleotide transport (GO:0015868)3.33431630
87amyloid precursor protein catabolic process (GO:0042987)3.33423743
88aromatic amino acid family metabolic process (GO:0009072)3.33031538
89alpha-amino acid catabolic process (GO:1901606)3.30375236
90glucuronate metabolic process (GO:0019585)3.26782500
91uronic acid metabolic process (GO:0006063)3.26782500
92ethanol metabolic process (GO:0006067)3.26764264
93positive regulation of T cell differentiation in thymus (GO:0033089)3.26510396
94positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.25242632
95short-chain fatty acid metabolic process (GO:0046459)3.25179228
96purine nucleotide transport (GO:0015865)3.25132153
97protein-lipid complex subunit organization (GO:0071825)3.22915434
98alpha-linolenic acid metabolic process (GO:0036109)3.20222534
99sulfur amino acid catabolic process (GO:0000098)3.19120573
100regulation of type I interferon-mediated signaling pathway (GO:0060338)3.18566422
101regulation of cholesterol metabolic process (GO:0090181)3.18489964
102NAD biosynthetic process (GO:0009435)3.18435463
103regulation of triglyceride catabolic process (GO:0010896)3.17981264
104negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.16600398
105indolalkylamine metabolic process (GO:0006586)3.16376856
106glutamate metabolic process (GO:0006536)3.14960767
107cellular modified amino acid catabolic process (GO:0042219)3.14180019
108glutamine family amino acid biosynthetic process (GO:0009084)3.13525282
109negative regulation of sterol transport (GO:0032372)3.11680961
110negative regulation of cholesterol transport (GO:0032375)3.11680961
111cysteine metabolic process (GO:0006534)3.11460441
112negative regulation of stress fiber assembly (GO:0051497)3.11165999
113ear development (GO:0043583)3.10424167
114response to interleukin-15 (GO:0070672)3.08890464
115intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.07892074
116desmosome organization (GO:0002934)3.06389552
117nitrogen cycle metabolic process (GO:0071941)3.05442144
118regulation of gamma-delta T cell activation (GO:0046643)3.05425543
119adenine nucleotide transport (GO:0051503)3.04982650
120cellular ketone body metabolic process (GO:0046950)3.04122086
121activation of MAPKKK activity (GO:0000185)3.03780266
122positive regulation of keratinocyte differentiation (GO:0045618)3.02167371
123acylglycerol homeostasis (GO:0055090)3.01552943
124triglyceride homeostasis (GO:0070328)3.01552943
125cellular amino acid catabolic process (GO:0009063)3.00830133
126cellular response to interleukin-4 (GO:0071353)2.98063236
127tRNA methylation (GO:0030488)2.97136867
128embryonic process involved in female pregnancy (GO:0060136)2.97078499
129water homeostasis (GO:0030104)2.96725323
130regulation of protein activation cascade (GO:2000257)2.96621638
131COPI coating of Golgi vesicle (GO:0048205)2.96430553
132Golgi transport vesicle coating (GO:0048200)2.96430553
133glyoxylate metabolic process (GO:0046487)2.95249735
134very-low-density lipoprotein particle assembly (GO:0034379)2.95002215
135tyrosine metabolic process (GO:0006570)2.94041643
136coenzyme catabolic process (GO:0009109)2.92851073
137positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.92265684
138negative regulation of lipase activity (GO:0060192)2.91026266
139lymphocyte migration (GO:0072676)2.90893343
140plasma lipoprotein particle assembly (GO:0034377)2.90142593
141negative regulation of cell killing (GO:0031342)2.87948359
142negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.87948359
143regulation of histone H3-K27 methylation (GO:0061085)2.87518659
144GDP-mannose metabolic process (GO:0019673)2.87031590
145positive regulation of fatty acid beta-oxidation (GO:0032000)2.86365792
146regulation of sequestering of triglyceride (GO:0010889)2.85150633
147negative regulation of astrocyte differentiation (GO:0048712)2.83755941
148negative regulation of granulocyte differentiation (GO:0030853)2.83369583
149bile acid metabolic process (GO:0008206)2.83307544
150rRNA transcription (GO:0009303)2.81522185
151regulation of fatty acid beta-oxidation (GO:0031998)2.78314825
152negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.78273800
153apoptotic process involved in morphogenesis (GO:0060561)2.77608845
154positive regulation of T cell mediated cytotoxicity (GO:0001916)2.77554572
155positive regulation of protein sumoylation (GO:0033235)2.77317683
156positive regulation of cholesterol transport (GO:0032376)2.76958282
157positive regulation of sterol transport (GO:0032373)2.76958282
158positive regulation of extracellular matrix organization (GO:1903055)2.76781300
159regulation of complement activation (GO:0030449)2.76512457
160response to type I interferon (GO:0034340)2.75665633
161signal complex assembly (GO:0007172)2.75124886
162positive regulation of steroid metabolic process (GO:0045940)2.74886117
163ketone body metabolic process (GO:1902224)2.74355431
164cellular response to type I interferon (GO:0071357)2.74041856
165type I interferon signaling pathway (GO:0060337)2.74041856
166positive regulation of DNA recombination (GO:0045911)2.74041283
167anion homeostasis (GO:0055081)2.73999937
168positive regulation of histone deacetylation (GO:0031065)2.73750138
169aminoglycoside antibiotic metabolic process (GO:0030647)2.73683594
170cholesterol catabolic process (GO:0006707)2.73130910
171sterol catabolic process (GO:0016127)2.73130910
172activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.70658397
173regulation of interleukin-5 production (GO:0032674)2.70174830
174nicotinamide nucleotide biosynthetic process (GO:0019359)2.69758289
175regulation of extracellular matrix organization (GO:1903053)2.69649831
176regulation of meiosis I (GO:0060631)2.69633484
177regulation of T cell tolerance induction (GO:0002664)2.67122282
178hepatocyte apoptotic process (GO:0097284)2.62057654
179regulation of apoptotic process involved in morphogenesis (GO:1902337)2.61905375
180activation of Rac GTPase activity (GO:0032863)2.61246135
181negative regulation of response to biotic stimulus (GO:0002832)2.61108933
182tumor necrosis factor-mediated signaling pathway (GO:0033209)2.60989723
183positive regulation of Cdc42 GTPase activity (GO:0043089)2.59989008
184mRNA transcription from RNA polymerase II promoter (GO:0042789)2.58596335
185regulation of translational fidelity (GO:0006450)2.57963811
186regulation of nuclease activity (GO:0032069)2.57416919
187positive regulation of nuclease activity (GO:0032075)2.56570153
188positive regulation of interleukin-2 production (GO:0032743)2.56131177
189negative regulation of interleukin-2 production (GO:0032703)2.54331570
190regulation of transforming growth factor beta1 production (GO:0032908)2.53596797
191histone H3-K4 methylation (GO:0051568)2.50816972
192cellular response to virus (GO:0098586)2.50495393
193mannose metabolic process (GO:0006013)2.49361470
194regulation of endothelial cell chemotaxis (GO:2001026)2.46957080
195regulation of T cell mediated cytotoxicity (GO:0001914)2.45478885
196prostaglandin biosynthetic process (GO:0001516)2.44717987
197prostanoid biosynthetic process (GO:0046457)2.44717987
198response to interleukin-4 (GO:0070670)2.42382941
199positive regulation of epidermis development (GO:0045684)2.42354111
200cell differentiation involved in embryonic placenta development (GO:0060706)2.40881532

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.03860042
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.79490546
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.53395740
4EGR1_23403033_ChIP-Seq_LIVER_Mouse3.47265189
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.31434153
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.08268727
7* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.97520557
8GATA1_22025678_ChIP-Seq_K562_Human2.90160416
9MYC_22102868_ChIP-Seq_BL_Human2.85933368
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.82322013
11GBX2_23144817_ChIP-Seq_PC3_Human2.81981465
12AR_21572438_ChIP-Seq_LNCaP_Human2.72355041
13LXR_22292898_ChIP-Seq_THP-1_Human2.45443172
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.39887197
15VDR_21846776_ChIP-Seq_THP-1_Human2.32692929
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.32385839
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.31084718
18* RACK7_27058665_Chip-Seq_MCF-7_Human2.30599078
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.19534797
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.19531391
21* MAF_26560356_Chip-Seq_TH1_Human2.12691623
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.12604284
23SMAD_19615063_ChIP-ChIP_OVARY_Human2.09228585
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.06864670
25NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.05318620
26* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.00459874
27HIF1A_21447827_ChIP-Seq_MCF-7_Human2.00128858
28KDM2B_26808549_Chip-Seq_SUP-B15_Human1.96683232
29TCF7_22412390_ChIP-Seq_EML_Mouse1.93704707
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.90228368
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.89057671
32KDM2B_26808549_Chip-Seq_DND41_Human1.88980771
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.88259731
34MAF_26560356_Chip-Seq_TH2_Human1.86497604
35UTX_26944678_Chip-Seq_JUKART_Human1.84291998
36RXR_22108803_ChIP-Seq_LS180_Human1.73245784
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71347357
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.66914499
39KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.64481637
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.59554151
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.58878237
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58271956
43P300_19829295_ChIP-Seq_ESCs_Human1.57451531
44TET1_21451524_ChIP-Seq_MESCs_Mouse1.56515722
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54126267
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53140632
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53140632
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51422094
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51174547
50EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.51061628
51ATF3_27146783_Chip-Seq_COLON_Human1.50908199
52MYB_26560356_Chip-Seq_TH1_Human1.50442290
53* RUNX1_27514584_Chip-Seq_MCF-7_Human1.50355958
54TP53_16413492_ChIP-PET_HCT116_Human1.49870864
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.48976421
56P68_20966046_ChIP-Seq_HELA_Human1.48626978
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48509731
58CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.47529588
59EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46809044
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.46292778
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46171133
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45866997
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45837792
64CTCF_27219007_Chip-Seq_ERYTHROID_Human1.42797417
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42413787
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.41684142
67ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40745870
68SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.39841831
69DCP1A_22483619_ChIP-Seq_HELA_Human1.39748762
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.39710253
71SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39255324
72SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.38486486
73SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.37821423
74JARID2_20064375_ChIP-Seq_MESCs_Mouse1.36321431
75IGF1R_20145208_ChIP-Seq_DFB_Human1.34995319
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.34792557
77* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34573613
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.34462526
79* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34298682
80TP53_18474530_ChIP-ChIP_U2OS_Human1.33472298
81IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32238639
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31515237
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30745843
84VDR_24763502_ChIP-Seq_THP-1_Human1.30289443
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29257411
86BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28590292
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28201019
88HTT_18923047_ChIP-ChIP_STHdh_Human1.27160032
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.26707635
90* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26649201
91MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26587193
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25868208
93XRN2_22483619_ChIP-Seq_HELA_Human1.25757278
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25346439
95* MYB_26560356_Chip-Seq_TH2_Human1.24923083
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24913281
97FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24750237
98* EZH2_27304074_Chip-Seq_ESCs_Mouse1.24382289
99ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24100748
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.23524361
101RARB_24833708_ChIP-Seq_LIVER_Mouse1.23494965
102DROSHA_22980978_ChIP-Seq_HELA_Human1.23036578
103EZH2_18974828_ChIP-Seq_MESCs_Mouse1.22750176
104RNF2_18974828_ChIP-Seq_MESCs_Mouse1.22750176
105CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22739937
106* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22666302
107* CREB1_26743006_Chip-Seq_LNCaP_Human1.22356822
108SMAD4_21799915_ChIP-Seq_A2780_Human1.22064784
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.22062430
110ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20095571
111SMC4_20622854_ChIP-Seq_HELA_Human1.19284135
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19198886
113KDM2B_26808549_Chip-Seq_K562_Human1.19184787
114EZH2_27294783_Chip-Seq_NPCs_Mouse1.18800732
115KDM2B_26808549_Chip-Seq_JURKAT_Human1.17299555
116RUNX1_22412390_ChIP-Seq_EML_Mouse1.16978388
117SCL_19346495_ChIP-Seq_HPC-7_Human1.16520386
118BCOR_27268052_Chip-Seq_Bcells_Human1.15438650
119RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15388355
120* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.15192493
121ERG_21242973_ChIP-ChIP_JURKAT_Human1.14332871
122ESR1_20079471_ChIP-ChIP_T-47D_Human1.13864319
123MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.13453440
124* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13284553
125SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12363954
126DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12301869
127AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12159868
128EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11642595
129MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11316080
130* RNF2_27304074_Chip-Seq_ESCs_Mouse1.11053212
131FOXA2_19822575_ChIP-Seq_HepG2_Human1.10662664
132EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10421456
133STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10160059
134AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10019568
135NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09937053
136NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09937053
137HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09843688
138BCL6_27268052_Chip-Seq_Bcells_Human1.09664703
139EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09487342
140NCOR1_26117541_ChIP-Seq_K562_Human1.09123503
141ETS1_20019798_ChIP-Seq_JURKAT_Human1.09036765
142NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08365973
143SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08131177
144TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07982833
145SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07053241
146PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07048968
147MYC_18358816_ChIP-ChIP_MESCs_Mouse1.06900990
148SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06859070
149FLI1_27457419_Chip-Seq_LIVER_Mouse1.05943494
150VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05726583
151TFEB_21752829_ChIP-Seq_HELA_Human1.05719454
152TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05703613
153CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04650983
154P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04649432
155CTCF_21964334_Chip-Seq_Bcells_Human1.04602631
156RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04523219
157AR_25329375_ChIP-Seq_VCAP_Human1.04152764
158STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03831308
159SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03624008
160ETS1_21867929_ChIP-Seq_TH2_Mouse1.03382817
161RARA_24833708_ChIP-Seq_LIVER_Mouse1.02997779
162CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02927866
163NANOG_18555785_Chip-Seq_ESCs_Mouse1.02722823
164ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02559336
165POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02145252
166RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01775531
167FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00985387
168PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98297388
169SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98096024
170TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.96835087
171E2F1_18555785_Chip-Seq_ESCs_Mouse0.96779009
172STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96461711
173* EZH2_27294783_Chip-Seq_ESCs_Mouse0.96351526
174TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96197721
175TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95749037
176P53_22387025_ChIP-Seq_ESCs_Mouse0.95410180
177SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95313504
178RUNX_20019798_ChIP-Seq_JUKART_Human0.93150388
179CJUN_26792858_Chip-Seq_BT549_Human0.93034654
180UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92916384
181TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90889348
182SOX2_18555785_Chip-Seq_ESCs_Mouse0.90728857
183CMYC_18555785_Chip-Seq_ESCs_Mouse0.90655595
184EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90142342
185IRF8_22096565_ChIP-ChIP_GC-B_Human0.89974937
186PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.89810260
187FUS_26573619_Chip-Seq_HEK293_Human0.89722622
188VDR_24787735_ChIP-Seq_THP-1_Human0.89592480
189TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89082686
190CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88823354
191CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88678954
192SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88549826
193CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88265620
194CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.87875649

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.84573320
2MP0002139_abnormal_hepatobiliary_system4.61897140
3MP0005365_abnormal_bile_salt4.33514979
4MP0005085_abnormal_gallbladder_physiolo4.30721331
5MP0002254_reproductive_system_inflammat3.94484142
6MP0003763_abnormal_thymus_physiology3.63818959
7MP0008875_abnormal_xenobiotic_pharmacok3.60200853
8MP0003806_abnormal_nucleotide_metabolis3.58973799
9MP0003191_abnormal_cellular_cholesterol3.40848155
10MP0010234_abnormal_vibrissa_follicle3.26570127
11MP0009840_abnormal_foam_cell3.13575434
12MP0004185_abnormal_adipocyte_glucose2.93381278
13MP0010329_abnormal_lipoprotein_level2.88312494
14MP0000685_abnormal_immune_system2.87648085
15MP0005671_abnormal_response_to2.86406876
16MP0002796_impaired_skin_barrier2.80647165
17MP0001873_stomach_inflammation2.74432695
18MP0004019_abnormal_vitamin_homeostasis2.70623720
19MP0005646_abnormal_pituitary_gland2.60422449
20MP0009333_abnormal_splenocyte_physiolog2.53739449
21MP0004381_abnormal_hair_follicle2.53122051
22MP0009697_abnormal_copulation2.50047799
23MP0005670_abnormal_white_adipose2.38879548
24MP0002098_abnormal_vibrissa_morphology2.29677878
25MP0005332_abnormal_amino_acid2.28687245
26MP0003453_abnormal_keratinocyte_physiol2.26775997
27MP0001348_abnormal_lacrimal_gland2.24934817
28MP0004947_skin_inflammation2.20944991
29MP0002166_altered_tumor_susceptibility2.20260465
30MP0005377_hearing/vestibular/ear_phenot2.20179972
31MP0003878_abnormal_ear_physiology2.20179972
32MP0003436_decreased_susceptibility_to2.06268472
33MP0001502_abnormal_circadian_rhythm2.04416093
34MP0001986_abnormal_taste_sensitivity2.01147256
35MP0005409_darkened_coat_color1.96912935
36MP0003252_abnormal_bile_duct1.96051643
37MP0002876_abnormal_thyroid_physiology1.92828492
38MP0005423_abnormal_somatic_nervous1.88895838
39MP0000703_abnormal_thymus_morphology1.84762803
40MP0003646_muscle_fatigue1.84112933
41MP0005000_abnormal_immune_tolerance1.83682496
42MP0001800_abnormal_humoral_immune1.79268805
43MP0005076_abnormal_cell_differentiation1.77340568
44MP0003300_gastrointestinal_ulcer1.74938623
45MP0003868_abnormal_feces_composition1.73215332
46MP0008995_early_reproductive_senescence1.72946490
47MP0005501_abnormal_skin_physiology1.71113993
48MP0005310_abnormal_salivary_gland1.69967327
49MP0002118_abnormal_lipid_homeostasis1.69403114
50MP0010155_abnormal_intestine_physiology1.68486638
51MP0000566_synostosis1.65810284
52MP0002420_abnormal_adaptive_immunity1.62909654
53MP0001819_abnormal_immune_cell1.62718358
54MP0005083_abnormal_biliary_tract1.61127715
55MP0004264_abnormal_extraembryonic_tissu1.60990146
56MP0002006_tumorigenesis1.60371007
57MP0002398_abnormal_bone_marrow1.59259484
58MP0002723_abnormal_immune_serum1.57459173
59MP0005025_abnormal_response_to1.57349324
60MP0003186_abnormal_redox_activity1.54713195
61MP0001835_abnormal_antigen_presentation1.53694513
62MP0000716_abnormal_immune_system1.52783614
63MP0002452_abnormal_antigen_presenting1.50337447
64MP0001346_abnormal_lacrimal_gland1.50211366
65MP0005058_abnormal_lysosome_morphology1.48192627
66MP0000678_abnormal_parathyroid_gland1.47011505
67MP0005666_abnormal_adipose_tissue1.46929042
68MP0002138_abnormal_hepatobiliary_system1.46388541
69MP0004742_abnormal_vestibular_system1.46037841
70MP0001666_abnormal_nutrient_absorption1.45798217
71MP0009785_altered_susceptibility_to1.44413613
72MP0002722_abnormal_immune_system1.41869124
73MP0001853_heart_inflammation1.40213320
74MP0000858_altered_metastatic_potential1.38374740
75MP0002736_abnormal_nociception_after1.35077082
76MP0000465_gastrointestinal_hemorrhage1.30682970
77MP0001216_abnormal_epidermal_layer1.30579251
78MP0009764_decreased_sensitivity_to1.29334093
79MP0005535_abnormal_body_temperature1.26643003
80MP0000689_abnormal_spleen_morphology1.23713198
81MP0002429_abnormal_blood_cell1.22945618
82MP0008961_abnormal_basal_metabolism1.22798071
83MP0003091_abnormal_cell_migration1.21900699
84MP0003866_abnormal_defecation1.21736589
85MP0005647_abnormal_sex_gland1.21273193
86MP0001270_distended_abdomen1.19756524
87MP0000609_abnormal_liver_physiology1.18620612
88MP0002249_abnormal_larynx_morphology1.18616900
89MP0004130_abnormal_muscle_cell1.18561679
90MP0003195_calcinosis1.18147393
91MP0003136_yellow_coat_color1.14658085
92MP0005023_abnormal_wound_healing1.13929043
93MP0002060_abnormal_skin_morphology1.13081675
94MP0008260_abnormal_autophagy1.12843027
95MP0000377_abnormal_hair_follicle1.09980076
96MP0004782_abnormal_surfactant_physiolog1.08306149
97MP0000627_abnormal_mammary_gland1.08243903
98MP0002282_abnormal_trachea_morphology1.07668150
99MP0004134_abnormal_chest_morphology1.05874821
100MP0000490_abnormal_crypts_of1.05012796
101MP0002163_abnormal_gland_morphology1.04304751
102MP0001845_abnormal_inflammatory_respons1.04041091
103MP0004510_myositis1.02338685
104MP0005451_abnormal_body_composition0.99492769
105MP0000604_amyloidosis0.99142065
106MP0000470_abnormal_stomach_morphology0.98393762
107MP0009931_abnormal_skin_appearance0.98363466
108MP0003690_abnormal_glial_cell0.98204643
109MP0000613_abnormal_salivary_gland0.97217791
110MP0003705_abnormal_hypodermis_morpholog0.95922787
111MP0005584_abnormal_enzyme/coenzyme_acti0.93554034
112MP0001486_abnormal_startle_reflex0.92489638
113MP0001501_abnormal_sleep_pattern0.92216500
114MP0002089_abnormal_postnatal_growth/wei0.90949325
115MP0008004_abnormal_stomach_pH0.90502293
116MP0005387_immune_system_phenotype0.90229640
117MP0001790_abnormal_immune_system0.90229640
118MP0002877_abnormal_melanocyte_morpholog0.89291963
119MP0003950_abnormal_plasma_membrane0.89157698
120MP0009763_increased_sensitivity_to0.88807261
121MP0002933_joint_inflammation0.88709900
122MP0001968_abnormal_touch/_nociception0.88572027
123MP0002396_abnormal_hematopoietic_system0.88367538
124MP0001851_eye_inflammation0.88282164
125MP0001764_abnormal_homeostasis0.87380597
126MP0002019_abnormal_tumor_incidence0.87119718
127MP0010678_abnormal_skin_adnexa0.86390867
128MP0005375_adipose_tissue_phenotype0.86097002
129MP0005319_abnormal_enzyme/_coenzyme0.85838435
130MP0009250_abnormal_appendicular_skeleto0.85459222
131MP0010771_integument_phenotype0.84633739
132MP0002419_abnormal_innate_immunity0.83800109
133MP0009115_abnormal_fat_cell0.83395142
134MP0001661_extended_life_span0.83038403
135MP0002405_respiratory_system_inflammati0.81597522
136MP0006138_congestive_heart_failure0.81440481
137MP0002132_abnormal_respiratory_system0.81416285
138MP0001849_ear_inflammation0.81308644
139MP0001440_abnormal_grooming_behavior0.80907930
140MP0001340_abnormal_eyelid_morphology0.79753301
141MP0003959_abnormal_lean_body0.79426837
142MP0001881_abnormal_mammary_gland0.79023220
143MP0001727_abnormal_embryo_implantation0.78274699
144MP0004858_abnormal_nervous_system0.77275001
145MP0009765_abnormal_xenobiotic_induced0.77184501
146MP0005379_endocrine/exocrine_gland_phen0.75893910
147MP0000750_abnormal_muscle_regeneration0.74458723
148MP0000477_abnormal_intestine_morphology0.74355594
149MP0000383_abnormal_hair_follicle0.74177483
150MP0000367_abnormal_coat/_hair0.74167365
151MP0003566_abnormal_cell_adhesion0.73817635
152MP0002277_abnormal_respiratory_mucosa0.72985510
153MP0002971_abnormal_brown_adipose0.72221721
154MP0001963_abnormal_hearing_physiology0.71583384
155MP0005166_decreased_susceptibility_to0.70814555
156MP0002148_abnormal_hypersensitivity_rea0.70302898
157MP0006292_abnormal_olfactory_placode0.70242158
158MP0009780_abnormal_chondrocyte_physiolo0.70030455
159MP0005334_abnormal_fat_pad0.70004535
160MP0002822_catalepsy0.69905456
161MP0003656_abnormal_erythrocyte_physiolo0.69359440
162MP0000537_abnormal_urethra_morphology0.68172196
163MP0003448_altered_tumor_morphology0.68159350
164MP0005448_abnormal_energy_balance0.67851332
165MP0009745_abnormal_behavioral_response0.66405944
166MP0000163_abnormal_cartilage_morphology0.66254872
167MP0000462_abnormal_digestive_system0.66189361
168MP0003786_premature_aging0.65265825
169MP0005248_abnormal_Harderian_gland0.65054371
170MP0005621_abnormal_cell_physiology0.62995928
171MP0009643_abnormal_urine_homeostasis0.62314845
172MP0004885_abnormal_endolymph0.61324145
173MP0003638_abnormal_response/metabolism_0.60634767
174MP0002115_abnormal_skeleton_extremities0.59253595
175MP0000598_abnormal_liver_morphology0.57731982
176MP0005220_abnormal_exocrine_pancreas0.57636448
177MP0004484_altered_response_of0.57493367
178MP0000026_abnormal_inner_ear0.56881890
179MP0008872_abnormal_physiological_respon0.55047933
180MP0003879_abnormal_hair_cell0.54359808
181MP0005503_abnormal_tendon_morphology0.53782203
182MP0005645_abnormal_hypothalamus_physiol0.53707586
183MP0001177_atelectasis0.53143309
184MP0004859_abnormal_synaptic_plasticity0.52887905
185MP0002078_abnormal_glucose_homeostasis0.52684919
186MP0003943_abnormal_hepatobiliary_system0.51987681

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)5.42676815
2Increased IgE level (HP:0003212)5.23467894
3Intrahepatic cholestasis (HP:0001406)4.84813208
4Abnormal tarsal ossification (HP:0008369)4.49705011
5Vitreoretinal degeneration (HP:0000655)4.15915708
6Hyperlipoproteinemia (HP:0010980)4.10458737
7Irregular epiphyses (HP:0010582)3.81408466
8Hypoalphalipoproteinemia (HP:0003233)3.68222263
9Xanthomatosis (HP:0000991)3.64458955
10Deep venous thrombosis (HP:0002625)3.61380845
11Pili torti (HP:0003777)3.59046188
12Abnormality of aromatic amino acid family metabolism (HP:0004338)3.55330255
13Neonatal short-limb short stature (HP:0008921)3.54970084
14Prolonged partial thromboplastin time (HP:0003645)3.50395213
15Broad face (HP:0000283)3.45296114
16Flat acetabular roof (HP:0003180)3.30391228
17Eczematoid dermatitis (HP:0000976)3.29058942
18Lip pit (HP:0100267)3.18789627
19Hypolipoproteinemia (HP:0010981)3.15727937
20Thoracic kyphosis (HP:0002942)3.15378968
21Recurrent bronchitis (HP:0002837)3.12715918
22Abnormality of glutamine family amino acid metabolism (HP:0010902)3.09351761
23Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.09023248
24Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.08026400
25Gastrointestinal stroma tumor (HP:0100723)3.07642764
26Hyperacusis (HP:0010780)3.04875759
27Chronic hepatic failure (HP:0100626)3.04840861
28Chronic diarrhea (HP:0002028)3.03064467
29Cone-rod dystrophy (HP:0000548)2.97062473
30Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.96694503
31Hypoglycemic seizures (HP:0002173)2.93710639
32Hypobetalipoproteinemia (HP:0003563)2.89666054
33Abnormality of the thoracic spine (HP:0100711)2.88979160
34Hyperglycinemia (HP:0002154)2.88910591
35IgA deficiency (HP:0002720)2.87735209
36J-shaped sella turcica (HP:0002680)2.78666175
37Hyperglycinuria (HP:0003108)2.77812492
38Verrucae (HP:0200043)2.76848237
39Papilloma (HP:0012740)2.76848237
40Abnormality of monocarboxylic acid metabolism (HP:0010996)2.72549188
41Genu varum (HP:0002970)2.72297001
42Small epiphyses (HP:0010585)2.71309175
43Increased intramyocellular lipid droplets (HP:0012240)2.69914936
44Hypoplastic ischia (HP:0003175)2.69620934
45Seborrheic dermatitis (HP:0001051)2.69186581
46IgM deficiency (HP:0002850)2.68941560
47Abnormality of proline metabolism (HP:0010907)2.67367833
48Hydroxyprolinuria (HP:0003080)2.67367833
49Lymphopenia (HP:0001888)2.66851568
50Ragged-red muscle fibers (HP:0003200)2.66844930
51Abnormal foot bone ossification (HP:0010675)2.65042402
52Hyperventilation (HP:0002883)2.64835982
53Abnormal hair laboratory examination (HP:0003328)2.64331425
54Loss of speech (HP:0002371)2.64171202
55Hypoglycemic coma (HP:0001325)2.62537083
56Abnormal biliary tract physiology (HP:0012439)2.62121293
57Bile duct proliferation (HP:0001408)2.62121293
58Macroorchidism (HP:0000053)2.62032037
59Neonatal hypoglycemia (HP:0001998)2.61924627
60Recurrent gram-negative bacterial infections (HP:0005420)2.60416887
61Cupped ribs (HP:0000887)2.59764654
62Hypoplasia of the thymus (HP:0000778)2.59333934
63Abnormality of serine family amino acid metabolism (HP:0010894)2.54850407
64Abnormality of glycine metabolism (HP:0010895)2.54850407
65Bronchitis (HP:0012387)2.50904348
66Fat malabsorption (HP:0002630)2.49550965
67Increased muscle lipid content (HP:0009058)2.49212815
68Long palpebral fissure (HP:0000637)2.48252238
69Mesomelia (HP:0003027)2.48229348
70Abnormality of fatty-acid metabolism (HP:0004359)2.47350532
71Micronodular cirrhosis (HP:0001413)2.45220261
72Enlarged kidneys (HP:0000105)2.44817585
73Abnormality of aspartate family amino acid metabolism (HP:0010899)2.44626156
74Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.43765843
75Trismus (HP:0000211)2.43600410
76Chronic sinusitis (HP:0011109)2.42920779
77Recurrent otitis media (HP:0000403)2.42117719
78Abnormality of cells of the lymphoid lineage (HP:0012140)2.41702599
79Milia (HP:0001056)2.40230001
80Abnormality of the ischium (HP:0003174)2.40107946
81Abnormality of sulfur amino acid metabolism (HP:0004339)2.38274516
82Abnormality of methionine metabolism (HP:0010901)2.35946317
83Abnormality of the common coagulation pathway (HP:0010990)2.35769604
84Cholecystitis (HP:0001082)2.35671434
85Abnormal gallbladder physiology (HP:0012438)2.35671434
86Congenital ichthyosiform erythroderma (HP:0007431)2.33516680
87Abnormality of the middle phalanges of the toes (HP:0010183)2.30535407
88Abnormality of the salivary glands (HP:0010286)2.26926621
89Joint hemorrhage (HP:0005261)2.25168999
90Hypoplasia of the capital femoral epiphysis (HP:0003090)2.24961847
91Hyperparathyroidism (HP:0000843)2.24854100
92Vascular calcification (HP:0004934)2.24251451
93Complement deficiency (HP:0004431)2.23407611
94Ovoid vertebral bodies (HP:0003300)2.20053859
95Renal cortical cysts (HP:0000803)2.19856068
96Hyperammonemia (HP:0001987)2.18615270
97Epidermoid cyst (HP:0200040)2.17188080
98Steatorrhea (HP:0002570)2.16013051
99Beaking of vertebral bodies (HP:0004568)2.15476121
100Abnormality of the phalanges of the 2nd finger (HP:0009541)2.15232359
101Abnormality of T cells (HP:0002843)2.15174696
102Short femoral neck (HP:0100864)2.15171841
103Abnormality of the lumbar spine (HP:0100712)2.14513581
104Progressive sensorineural hearing impairment (HP:0000408)2.14082207
105IgG deficiency (HP:0004315)2.12026334
106Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.10457649
107Hypercortisolism (HP:0001578)2.09794889
108Abnormality of carpal bone ossification (HP:0006257)2.09729140
109Growth hormone excess (HP:0000845)2.07974254
110Carpal bone hypoplasia (HP:0001498)2.04806699
111Aplasia/hypoplasia of the femur (HP:0005613)2.04723415
112Recurrent sinusitis (HP:0011108)2.04421785
113Nail dystrophy (HP:0008404)2.04366103
114Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.03807396
115Emphysema (HP:0002097)2.03689365
116Abnormality of serum amino acid levels (HP:0003112)2.03329909
117Flattened epiphyses (HP:0003071)2.02210513
118Gastrointestinal inflammation (HP:0004386)2.01978897
119Symptomatic seizures (HP:0011145)2.01684510
120Metaphyseal dysplasia (HP:0100255)2.01621152
121Hypochromic microcytic anemia (HP:0004840)2.01462360
122Neuronal loss in central nervous system (HP:0002529)2.00262843
123Osteoarthritis (HP:0002758)2.00208572
124Abnormality of secondary sexual hair (HP:0009888)1.99729068
125Abnormality of the axillary hair (HP:0100134)1.99729068
126Basal cell carcinoma (HP:0002671)1.97498577
127Increased neuronal autofluorescent lipopigment (HP:0002074)1.97393479
128Plantar hyperkeratosis (HP:0007556)1.96732978
129Cervical subluxation (HP:0003308)1.96460742
130Paraparesis (HP:0002385)1.96370724
131Ridged nail (HP:0001807)1.96066963
132Cardiovascular calcification (HP:0011915)1.95970946
133Myokymia (HP:0002411)1.95960497
134Ketosis (HP:0001946)1.95236067
135Obstructive sleep apnea (HP:0002870)1.94974081
136Self-mutilation (HP:0000742)1.94901416
137Agammaglobulinemia (HP:0004432)1.93614754
138Absent epiphyses (HP:0010577)1.93022710
139Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.93022710
140Depressed nasal tip (HP:0000437)1.92956877
141Onycholysis (HP:0001806)1.92892439
142Thin ribs (HP:0000883)1.91381270
143Elevated alkaline phosphatase (HP:0003155)1.91204892
144Distal lower limb muscle weakness (HP:0009053)1.90974008
145Arthropathy (HP:0003040)1.90828583
146Panhypogammaglobulinemia (HP:0003139)1.88958681
147Respiratory distress (HP:0002098)1.88637443
148Abnormality of the femoral head (HP:0003368)1.88462494
149Abnormality of T cell physiology (HP:0011840)1.88342255
150Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.88275313
151Abnormal sex determination (HP:0012244)1.87739393
152Sex reversal (HP:0012245)1.87739393
153Hyperbilirubinemia (HP:0002904)1.87636596
154Abnormality of femoral epiphyses (HP:0006499)1.86517659
155Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.86517659
156Relative macrocephaly (HP:0004482)1.85829522
157Reduced antithrombin III activity (HP:0001976)1.85741579
158Slow saccadic eye movements (HP:0000514)1.85338187
159Conjugated hyperbilirubinemia (HP:0002908)1.85217037
160Recurrent fungal infections (HP:0002841)1.84672581
161Bronchomalacia (HP:0002780)1.84283520
162Mitral stenosis (HP:0001718)1.83714081
163Biconcave vertebral bodies (HP:0004586)1.83446292
164Ectopia lentis (HP:0001083)1.83000921
165Hepatoblastoma (HP:0002884)1.82868182
166Recurrent viral infections (HP:0004429)1.82684043
167Increased variability in muscle fiber diameter (HP:0003557)1.80876253
168Colitis (HP:0002583)1.80594275
169Abnormality of the gastric mucosa (HP:0004295)1.77733021
170Deformed sella turcica (HP:0002681)1.76722130
171Septate vagina (HP:0001153)1.76437920
172Insomnia (HP:0100785)1.75238836
173Multiple lipomas (HP:0001012)1.74838528
174Peripheral hypomyelination (HP:0007182)1.74799680
175Villous atrophy (HP:0011473)1.74743481
176Abnormality of small intestinal villus morphology (HP:0011472)1.74743481
177Hypotrichosis (HP:0001006)1.74596498
178Abnormality of alkaline phosphatase activity (HP:0004379)1.73729892
179Achilles tendon contracture (HP:0001771)1.72899640
180Optic neuritis (HP:0100653)1.72490785
181Retrobulbar optic neuritis (HP:0100654)1.72490785
182Progressive hearing impairment (HP:0001730)1.72390675
183Dysmetric saccades (HP:0000641)1.72380280
184Rough bone trabeculation (HP:0100670)1.72220645
185Increased cerebral lipofuscin (HP:0011813)1.71630685
186Abnormal blistering of the skin (HP:0008066)1.70602740
187Glossoptosis (HP:0000162)1.69857657
188Abnormality of skeletal muscle fiber size (HP:0012084)1.68406986
189Dysostosis multiplex (HP:0000943)1.66959202
190Pustule (HP:0200039)1.66950506
191Recurrent cutaneous fungal infections (HP:0011370)1.65912853
192Chronic mucocutaneous candidiasis (HP:0002728)1.65912853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.72984685
2SIK14.49109870
3SIK33.99373805
4SCYL23.70939363
5MAP4K13.70664184
6SMG13.55153800
7PRPF4B3.46945743
8EPHA23.09416401
9MUSK3.00869826
10CASK2.33710132
11MAPKAPK32.29826537
12SIK22.23302824
13TXK2.20036304
14TRPM72.19968716
15MAP3K142.18312099
16ERBB32.13168253
17NME22.01651612
18PKN21.98356607
19MARK31.88154133
20STK241.81595413
21ICK1.79029623
22EPHA41.77694073
23ERN11.65138577
24SGK21.64834996
25PINK11.57440299
26NME11.56473364
27MAP2K71.53691348
28TEC1.52593455
29SGK31.50571989
30MAP3K21.47375707
31TAOK21.45997479
32TNIK1.43831464
33MAPK131.43604002
34MST1R1.42429338
35LATS11.40359152
36BMX1.40184356
37BCKDK1.38419519
38NTRK31.36270988
39IKBKE1.34385227
40MST41.30569717
41CAMKK21.29083648
42MAPK111.28478147
43INSRR1.25407900
44PRKD31.22856407
45MAP2K31.22374843
46DAPK21.20016450
47SGK4941.14807605
48SGK2231.14807605
49HIPK21.14234260
50ADRBK21.13185562
51MAPK71.08191996
52MAP3K71.07280654
53PAK41.05261052
54EPHB11.04718499
55IRAK31.04534001
56CDK121.04077758
57CAMK1D1.02880052
58TESK11.01284251
59MAPK121.01015679
60CAMKK10.97406757
61BMPR20.97312205
62MAPK150.96990281
63IRAK40.96601200
64MAP3K40.96544169
65TYK20.95009718
66STK100.94778682
67DAPK10.94769940
68IRAK10.92540535
69DDR20.91714328
70MAP3K30.91091008
71STK38L0.89625874
72FGFR40.87615859
73PRKCE0.86760007
74PRKCG0.85990971
75CAMK40.82948594
76MAP2K40.82050642
77JAK10.81093533
78GRK10.80376364
79EEF2K0.78922060
80CAMK1G0.78291504
81VRK20.77391919
82MAPKAPK20.77140747
83CDK30.75941058
84MAP2K20.75406117
85TESK20.74466868
86CDC42BPA0.74416170
87LMTK20.73956283
88PDPK10.73486228
89PRKD20.73047295
90KDR0.73019990
91STK160.71944918
92JAK30.71712856
93MAP3K130.71146351
94TAOK10.71108499
95SRPK10.69985939
96ARAF0.69911926
97BTK0.69737505
98MAP3K110.69631480
99PAK30.68999899
100MTOR0.68681070
101MAP3K120.68104350
102TBK10.65803777
103STK30.65516210
104PRKCH0.65057154
105TYRO30.64998931
106TTN0.63629245
107RPS6KB10.63289655
108ZAP700.63243162
109ILK0.61793385
110MARK20.61534148
111BCR0.61001245
112PDK10.60893366
113YES10.59748626
114ITK0.59366758
115CAMK10.57908748
116GRK60.57158856
117PRKCI0.56446604
118EIF2AK20.55547496
119NUAK10.55477872
120PTK60.55140318
121MKNK20.55081319
122RIPK40.54621777
123RPS6KA40.53276958
124PRKAA10.52696463
125IKBKB0.52614899
126CHUK0.51318231
127MAP2K60.50067137
128FGFR30.49306889
129RPS6KB20.48765273
130IRAK20.48566243
131MAP3K90.48532899
132PRKCQ0.48492231
133DAPK30.48133889
134MAP3K100.47141409
135MAP3K60.46512754
136LRRK20.45494137
137CDK70.44080882
138RPS6KA20.43751237
139MAP3K10.43663163
140CSF1R0.43255810
141TRIB30.42255031
142MAPK40.41582484
143MAP3K80.41538537
144LCK0.40285722
145PRKCD0.40128510
146STK380.39670555
147CDK90.39178717
148CSK0.39037230
149PASK0.38355612
150PIM20.37991154
151EIF2AK30.37043825
152PRKAA20.36991134
153MAP3K50.36601554
154KSR10.35450583
155PRKG20.34909769
156CAMK2A0.34268986
157RPS6KL10.33384500
158RPS6KC10.33384500
159PRKACG0.33256253
160CSNK1G20.32778631
161ADRBK10.32125013
162PRKCA0.29540336
163IGF1R0.28899873
164SYK0.28872583
165PLK20.28777636
166PDK40.28695124
167PDK30.28695124
168PIM10.28213249
169PRKG10.27077860
170TNK20.24179804
171MAP2K10.24143275
172NLK0.23608262
173EPHA30.23489449
174MAPK30.22041886

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.24945744
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.73521946
3Fatty acid degradation_Homo sapiens_hsa000713.39524783
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.94712430
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.78981145
6Antigen processing and presentation_Homo sapiens_hsa046122.68736908
7T cell receptor signaling pathway_Homo sapiens_hsa046602.58232960
8Arginine biosynthesis_Homo sapiens_hsa002202.55746401
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.55246584
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39807458
11PPAR signaling pathway_Homo sapiens_hsa033202.31890407
12Tryptophan metabolism_Homo sapiens_hsa003802.26867289
13Autoimmune thyroid disease_Homo sapiens_hsa053202.13537076
14Peroxisome_Homo sapiens_hsa041462.10832328
15Allograft rejection_Homo sapiens_hsa053302.08384365
16Acute myeloid leukemia_Homo sapiens_hsa052212.05233398
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.02031482
18Fatty acid metabolism_Homo sapiens_hsa012122.01400480
19B cell receptor signaling pathway_Homo sapiens_hsa046621.97968104
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.94496720
21Graft-versus-host disease_Homo sapiens_hsa053321.93029927
22Fatty acid biosynthesis_Homo sapiens_hsa000611.91480866
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.85410642
24Complement and coagulation cascades_Homo sapiens_hsa046101.82087647
25Tyrosine metabolism_Homo sapiens_hsa003501.75338577
26Vibrio cholerae infection_Homo sapiens_hsa051101.75106727
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73421464
28Prion diseases_Homo sapiens_hsa050201.72437607
29Measles_Homo sapiens_hsa051621.69784208
30Viral myocarditis_Homo sapiens_hsa054161.65182833
31Propanoate metabolism_Homo sapiens_hsa006401.64100358
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.63826769
33VEGF signaling pathway_Homo sapiens_hsa043701.63365922
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62589653
35Histidine metabolism_Homo sapiens_hsa003401.60965247
36Type I diabetes mellitus_Homo sapiens_hsa049401.60761247
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.59670572
38Bile secretion_Homo sapiens_hsa049761.57200149
39beta-Alanine metabolism_Homo sapiens_hsa004101.56800806
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53809352
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.53422202
42Systemic lupus erythematosus_Homo sapiens_hsa053221.53063932
43Viral carcinogenesis_Homo sapiens_hsa052031.50181201
44Hepatitis C_Homo sapiens_hsa051601.48676276
45Retinol metabolism_Homo sapiens_hsa008301.47014474
46Butanoate metabolism_Homo sapiens_hsa006501.45659396
47Apoptosis_Homo sapiens_hsa042101.42969519
48Phenylalanine metabolism_Homo sapiens_hsa003601.42177634
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.41528987
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41378856
51Caffeine metabolism_Homo sapiens_hsa002321.41317144
52Chemical carcinogenesis_Homo sapiens_hsa052041.40753226
53Sulfur metabolism_Homo sapiens_hsa009201.40697791
54Herpes simplex infection_Homo sapiens_hsa051681.39555694
55Hepatitis B_Homo sapiens_hsa051611.37814495
56TNF signaling pathway_Homo sapiens_hsa046681.37173331
57Steroid biosynthesis_Homo sapiens_hsa001001.37162836
58Notch signaling pathway_Homo sapiens_hsa043301.33838614
59Cysteine and methionine metabolism_Homo sapiens_hsa002701.32619105
60Steroid hormone biosynthesis_Homo sapiens_hsa001401.31052148
61Selenocompound metabolism_Homo sapiens_hsa004501.29675062
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27401305
63Epstein-Barr virus infection_Homo sapiens_hsa051691.26583502
64Lysine degradation_Homo sapiens_hsa003101.26233564
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25498307
66HTLV-I infection_Homo sapiens_hsa051661.23490446
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.21251384
68Central carbon metabolism in cancer_Homo sapiens_hsa052301.16825470
69Influenza A_Homo sapiens_hsa051641.16493789
70Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13998801
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.13259997
72Spliceosome_Homo sapiens_hsa030401.10730732
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06674842
74ABC transporters_Homo sapiens_hsa020101.05743998
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03049816
76Glycerolipid metabolism_Homo sapiens_hsa005611.02781915
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02677815
78Circadian rhythm_Homo sapiens_hsa047101.02481406
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01693818
80Sphingolipid signaling pathway_Homo sapiens_hsa040711.01266086
81Osteoclast differentiation_Homo sapiens_hsa043801.01230620
82Endometrial cancer_Homo sapiens_hsa052131.00983765
83Fatty acid elongation_Homo sapiens_hsa000621.00902160
84One carbon pool by folate_Homo sapiens_hsa006700.99326948
85Non-small cell lung cancer_Homo sapiens_hsa052230.99112068
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97849066
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.95430161
88Toxoplasmosis_Homo sapiens_hsa051450.94338235
89Pancreatic cancer_Homo sapiens_hsa052120.93113250
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92195987
91Arginine and proline metabolism_Homo sapiens_hsa003300.88733791
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.88479981
93Starch and sucrose metabolism_Homo sapiens_hsa005000.85966792
94Prolactin signaling pathway_Homo sapiens_hsa049170.85561588
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85476415
96Pentose phosphate pathway_Homo sapiens_hsa000300.84475652
97Renal cell carcinoma_Homo sapiens_hsa052110.84154089
98Chronic myeloid leukemia_Homo sapiens_hsa052200.84131034
99Prostate cancer_Homo sapiens_hsa052150.80586247
100Pyruvate metabolism_Homo sapiens_hsa006200.78206691
101Base excision repair_Homo sapiens_hsa034100.77989575
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77427908
103MAPK signaling pathway_Homo sapiens_hsa040100.75115780
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74147789
105Endocytosis_Homo sapiens_hsa041440.74112417
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.73577834
107mRNA surveillance pathway_Homo sapiens_hsa030150.73530217
108Vitamin digestion and absorption_Homo sapiens_hsa049770.73383040
109Insulin signaling pathway_Homo sapiens_hsa049100.72340931
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71900223
111GnRH signaling pathway_Homo sapiens_hsa049120.71337784
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.71134020
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69411801
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68792897
115Tuberculosis_Homo sapiens_hsa051520.67604735
116Biosynthesis of amino acids_Homo sapiens_hsa012300.66505142
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65416660
118Ovarian steroidogenesis_Homo sapiens_hsa049130.65329355
119Shigellosis_Homo sapiens_hsa051310.65207440
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64095016
121Fructose and mannose metabolism_Homo sapiens_hsa000510.63152800
122Small cell lung cancer_Homo sapiens_hsa052220.63010181
123Leishmaniasis_Homo sapiens_hsa051400.62329623
124Estrogen signaling pathway_Homo sapiens_hsa049150.59485057
125N-Glycan biosynthesis_Homo sapiens_hsa005100.59332498
126Glucagon signaling pathway_Homo sapiens_hsa049220.59207358
127Colorectal cancer_Homo sapiens_hsa052100.58678447
128AMPK signaling pathway_Homo sapiens_hsa041520.58410216
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57785823
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57547001
131Inositol phosphate metabolism_Homo sapiens_hsa005620.57454845
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56680424
133Staphylococcus aureus infection_Homo sapiens_hsa051500.56449388
134Other glycan degradation_Homo sapiens_hsa005110.55942843
135Intestinal immune network for IgA production_Homo sapiens_hsa046720.55610929
136Alcoholism_Homo sapiens_hsa050340.55567374
137Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54990570
138RNA transport_Homo sapiens_hsa030130.54923383
139Folate biosynthesis_Homo sapiens_hsa007900.54314844
140Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54148210
141Nicotine addiction_Homo sapiens_hsa050330.52614280
142Vitamin B6 metabolism_Homo sapiens_hsa007500.51161841
143ErbB signaling pathway_Homo sapiens_hsa040120.50727876
144Sulfur relay system_Homo sapiens_hsa041220.50589840
145FoxO signaling pathway_Homo sapiens_hsa040680.48138511
146Taste transduction_Homo sapiens_hsa047420.47239509
147Morphine addiction_Homo sapiens_hsa050320.46336077
148Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44721787
149Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43406273
150Chemokine signaling pathway_Homo sapiens_hsa040620.43040631
151Carbon metabolism_Homo sapiens_hsa012000.41743640
152Adipocytokine signaling pathway_Homo sapiens_hsa049200.41368196
153RNA polymerase_Homo sapiens_hsa030200.41254850
154Dorso-ventral axis formation_Homo sapiens_hsa043200.40692295
155Bladder cancer_Homo sapiens_hsa052190.38976487
156Circadian entrainment_Homo sapiens_hsa047130.36760888
157African trypanosomiasis_Homo sapiens_hsa051430.34549916
158Glutamatergic synapse_Homo sapiens_hsa047240.33504325
159Metabolic pathways_Homo sapiens_hsa011000.33192552
160Glycerophospholipid metabolism_Homo sapiens_hsa005640.32780872
161Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32566887
162Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32037804
163Rheumatoid arthritis_Homo sapiens_hsa053230.30483099
164Fat digestion and absorption_Homo sapiens_hsa049750.29529406
165Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27318364
166Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27154295
167Insulin secretion_Homo sapiens_hsa049110.27091285
168Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26125665
169Insulin resistance_Homo sapiens_hsa049310.24702215
170Olfactory transduction_Homo sapiens_hsa047400.24679263
171Salivary secretion_Homo sapiens_hsa049700.23076069
172GABAergic synapse_Homo sapiens_hsa047270.20834767
173Galactose metabolism_Homo sapiens_hsa000520.20577898
174Choline metabolism in cancer_Homo sapiens_hsa052310.20478095
175Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.18352964
176Glycosaminoglycan degradation_Homo sapiens_hsa005310.17835356
177Calcium signaling pathway_Homo sapiens_hsa040200.17807718
178Maturity onset diabetes of the young_Homo sapiens_hsa049500.17520721
179Thyroid cancer_Homo sapiens_hsa052160.16733848
180Sphingolipid metabolism_Homo sapiens_hsa006000.16367873
181Phosphatidylinositol signaling system_Homo sapiens_hsa040700.16325037
182HIF-1 signaling pathway_Homo sapiens_hsa040660.16084426
183Primary immunodeficiency_Homo sapiens_hsa053400.15920238
184Gastric acid secretion_Homo sapiens_hsa049710.15291473

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