C2CD4C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)5.39501982
2daunorubicin metabolic process (GO:0044597)5.39501982
3polyketide metabolic process (GO:0030638)5.39501982
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.98727915
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.94144991
6vocalization behavior (GO:0071625)4.65950584
7neuron cell-cell adhesion (GO:0007158)4.52845012
8regulation of glutamate receptor signaling pathway (GO:1900449)4.50833536
9presynaptic membrane assembly (GO:0097105)4.47057054
10positive regulation of synapse maturation (GO:0090129)4.47026614
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.45050253
12positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.43025788
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.40674281
14regulation of synaptic vesicle exocytosis (GO:2000300)4.26670764
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.24205278
16postsynaptic membrane organization (GO:0001941)4.23806239
17cell migration in hindbrain (GO:0021535)4.21060038
18positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.17754535
19cellular potassium ion homeostasis (GO:0030007)4.12799927
20presynaptic membrane organization (GO:0097090)4.12203668
21establishment of mitochondrion localization (GO:0051654)4.09883564
22pyrimidine nucleobase catabolic process (GO:0006208)4.02151212
23positive regulation of dendritic spine development (GO:0060999)4.00148337
24sodium ion export (GO:0071436)3.99882004
25synaptic transmission, glutamatergic (GO:0035249)3.93033953
26startle response (GO:0001964)3.92952616
27regulation of synaptic vesicle transport (GO:1902803)3.91847963
28protein localization to synapse (GO:0035418)3.91109811
29regulation of synapse structural plasticity (GO:0051823)3.86729160
30establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.84739209
31mitochondrion transport along microtubule (GO:0047497)3.84739209
32locomotory exploration behavior (GO:0035641)3.81382481
33neuromuscular process controlling balance (GO:0050885)3.80899151
34synaptic vesicle maturation (GO:0016188)3.77505070
35positive regulation of dendritic spine morphogenesis (GO:0061003)3.77372530
36regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.75842475
37synaptic vesicle exocytosis (GO:0016079)3.66310384
38glutamate receptor signaling pathway (GO:0007215)3.65333783
39positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.61963421
40neurotransmitter-gated ion channel clustering (GO:0072578)3.61340925
41proline transport (GO:0015824)3.54052362
42glutamate secretion (GO:0014047)3.48072224
43positive regulation of synaptic transmission, GABAergic (GO:0032230)3.47980238
44cerebellar granule cell differentiation (GO:0021707)3.44283219
45positive regulation of neurotransmitter secretion (GO:0001956)3.43986569
46neuron-neuron synaptic transmission (GO:0007270)3.42058999
47dendritic spine morphogenesis (GO:0060997)3.40075687
48regulation of voltage-gated calcium channel activity (GO:1901385)3.39105965
49gamma-aminobutyric acid signaling pathway (GO:0007214)3.34778434
50adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.34542603
51neuron recognition (GO:0008038)3.33341356
52transmission of nerve impulse (GO:0019226)3.33270241
53amino acid import (GO:0043090)3.32663568
54G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.31687032
55nucleobase catabolic process (GO:0046113)3.30925667
56cell communication by electrical coupling (GO:0010644)3.30318615
57regulation of dendritic spine morphogenesis (GO:0061001)3.29562362
58synaptic vesicle endocytosis (GO:0048488)3.28530427
59regulation of neurotransmitter levels (GO:0001505)3.27382446
60axonal fasciculation (GO:0007413)3.26394094
61L-amino acid import (GO:0043092)3.25681807
62central nervous system projection neuron axonogenesis (GO:0021952)3.23547202
63response to pheromone (GO:0019236)3.22311559
64aminoglycoside antibiotic metabolic process (GO:0030647)3.21731429
65opioid receptor signaling pathway (GO:0038003)3.21333529
66dopamine receptor signaling pathway (GO:0007212)3.21024478
67axon extension (GO:0048675)3.20211763
68response to dietary excess (GO:0002021)3.18981198
69regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.18134590
70cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.17968297
71exploration behavior (GO:0035640)3.17097195
72regulation of neuronal synaptic plasticity (GO:0048168)3.14816461
73negative regulation of synaptic transmission, GABAergic (GO:0032229)3.13311074
74regulation of excitatory postsynaptic membrane potential (GO:0060079)3.09503723
75regulation of neurotransmitter secretion (GO:0046928)3.08591061
76negative regulation of dendrite morphogenesis (GO:0050774)3.08072803
77negative regulation of microtubule polymerization (GO:0031115)3.07890364
78neurotransmitter secretion (GO:0007269)3.07292870
79detection of calcium ion (GO:0005513)3.06353831
80regulation of dendritic spine development (GO:0060998)3.03690813
81regulation of postsynaptic membrane potential (GO:0060078)3.02873146
82gamma-aminobutyric acid transport (GO:0015812)3.02795138
83regulation of long-term neuronal synaptic plasticity (GO:0048169)3.00945113
84innervation (GO:0060384)3.00559011
85neuron projection extension (GO:1990138)3.00252428
86regulation of respiratory system process (GO:0044065)2.97802378
87synapse assembly (GO:0007416)2.97105472
88activation of protein kinase A activity (GO:0034199)2.94413000
89neuromuscular process (GO:0050905)2.93186099
90negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.93140537
91G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.91997667
92positive regulation of dendrite development (GO:1900006)2.91100121
93cytoskeletal anchoring at plasma membrane (GO:0007016)2.90428399
94long-term memory (GO:0007616)2.90184952
95regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.88953809
96positive regulation of synapse assembly (GO:0051965)2.88550794
97response to auditory stimulus (GO:0010996)2.87786897
98membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.86889394
99intraspecies interaction between organisms (GO:0051703)2.86096872
100social behavior (GO:0035176)2.86096872
101regulation of vesicle fusion (GO:0031338)2.85211384
102auditory behavior (GO:0031223)2.85189388
103cerebral cortex radially oriented cell migration (GO:0021799)2.83842952
104neuronal ion channel clustering (GO:0045161)2.82908464
105neuromuscular synaptic transmission (GO:0007274)2.82513938
106regulation of synaptic transmission, glutamatergic (GO:0051966)2.80925326
107regulation of synapse assembly (GO:0051963)2.79950033
108positive regulation of neurotransmitter transport (GO:0051590)2.79608784
109long-term synaptic potentiation (GO:0060291)2.79020471
110positive regulation of membrane potential (GO:0045838)2.77536479
111chemosensory behavior (GO:0007635)2.77351391
112cerebellar Purkinje cell differentiation (GO:0021702)2.76916985
113regulation of respiratory gaseous exchange (GO:0043576)2.76730309
114regulation of synaptic transmission (GO:0050804)2.76712773
115righting reflex (GO:0060013)2.76291467
116neuronal action potential propagation (GO:0019227)2.74510816
117membrane depolarization (GO:0051899)2.73584879
118regulation of synaptic transmission, GABAergic (GO:0032228)2.72569670
119regulation of synapse maturation (GO:0090128)2.71891617
120membrane hyperpolarization (GO:0060081)2.70806977
121superoxide anion generation (GO:0042554)2.70759344
122neurotransmitter transport (GO:0006836)2.68462895
123cochlea development (GO:0090102)2.68424351
124membrane depolarization during action potential (GO:0086010)2.67674046
125inner ear receptor stereocilium organization (GO:0060122)2.65641990
126layer formation in cerebral cortex (GO:0021819)2.65336863
127auditory receptor cell stereocilium organization (GO:0060088)2.65070038
128regulation of neurotransmitter transport (GO:0051588)2.64649265
129mechanosensory behavior (GO:0007638)2.61376498
130urinary tract smooth muscle contraction (GO:0014848)2.60209130
131cerebellum development (GO:0021549)2.59287681
132prostate gland growth (GO:0060736)2.59167827
133regulation of synaptic plasticity (GO:0048167)2.58673993
134central nervous system neuron axonogenesis (GO:0021955)2.56887245
135calcium ion import (GO:0070509)2.55602728
136positive regulation of action potential (GO:0045760)2.54549666
137learning (GO:0007612)2.54357527
138dendrite development (GO:0016358)2.52940990
139vesicle docking involved in exocytosis (GO:0006904)2.51647228
140energy homeostasis (GO:0097009)2.50752559
141dendritic spine organization (GO:0097061)2.49812116
142neuron remodeling (GO:0016322)2.49765788
143regulation of cAMP-dependent protein kinase activity (GO:2000479)2.49106214

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.43593581
2GBX2_23144817_ChIP-Seq_PC3_Human4.28242177
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.18418860
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.09708936
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.68993604
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62190894
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.59644878
8ZFP281_18757296_ChIP-ChIP_E14_Mouse2.57159491
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.52492512
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.41968887
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.41268874
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.38328345
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.37434529
14REST_21632747_ChIP-Seq_MESCs_Mouse2.34974461
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34760447
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33808909
17ERG_21242973_ChIP-ChIP_JURKAT_Human2.29468861
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.28660733
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22673341
20IGF1R_20145208_ChIP-Seq_DFB_Human2.22015359
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.15272370
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.15272370
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.12644918
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.09203664
25BMI1_23680149_ChIP-Seq_NPCS_Mouse2.05188673
26* KDM2B_26808549_Chip-Seq_K562_Human2.05166585
27* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.03350357
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.02925650
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02622658
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.01486734
31EZH2_27294783_Chip-Seq_ESCs_Mouse2.00375051
32* RNF2_27304074_Chip-Seq_ESCs_Mouse1.95979027
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.93812789
34* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91428686
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.91286386
36RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.86302354
37DROSHA_22980978_ChIP-Seq_HELA_Human1.86106831
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.84870997
39CTCF_27219007_Chip-Seq_Bcells_Human1.84419704
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81811378
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.80707725
42ZFP281_27345836_Chip-Seq_ESCs_Mouse1.80056789
43TAF15_26573619_Chip-Seq_HEK293_Human1.79105864
44P300_19829295_ChIP-Seq_ESCs_Human1.78695221
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78398919
46RNF2_27304074_Chip-Seq_NSC_Mouse1.76374220
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68609521
48SMAD4_21799915_ChIP-Seq_A2780_Human1.68404561
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.68044797
50EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.66327049
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66256938
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.62695354
53TP53_20018659_ChIP-ChIP_R1E_Mouse1.58522142
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57912118
55REST_18959480_ChIP-ChIP_MESCs_Mouse1.56679422
56OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.55236501
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.54452204
58SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.52542783
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52276581
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.50620144
61GATA1_26923725_Chip-Seq_HPCs_Mouse1.47439012
62RING1B_27294783_Chip-Seq_NPCs_Mouse1.47063981
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.44400695
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43381714
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43053756
66CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42801902
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42335060
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.41774173
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41742350
70E2F1_18555785_Chip-Seq_ESCs_Mouse1.41651538
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.41470080
72LXR_22292898_ChIP-Seq_THP-1_Human1.40025758
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37785641
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37296816
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.35537355
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34535855
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34535855
78SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34392349
79TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.34359315
80* TET1_21490601_ChIP-Seq_MESCs_Mouse1.33482120
81STAT3_23295773_ChIP-Seq_U87_Human1.33392844
82FUS_26573619_Chip-Seq_HEK293_Human1.32418455
83ZNF274_21170338_ChIP-Seq_K562_Hela1.31766082
84AR_25329375_ChIP-Seq_VCAP_Human1.30389332
85P53_22387025_ChIP-Seq_ESCs_Mouse1.29850919
86KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29282483
87NFE2_27457419_Chip-Seq_LIVER_Mouse1.29152268
88CMYC_18555785_Chip-Seq_ESCs_Mouse1.28863382
89CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26666716
90SUZ12_18555785_Chip-Seq_ESCs_Mouse1.25425436
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23401087
92SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22501988
93AR_21572438_ChIP-Seq_LNCaP_Human1.21769867
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21520576
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21460499
96TCF4_23295773_ChIP-Seq_U87_Human1.21219734
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21050460
98NMYC_18555785_Chip-Seq_ESCs_Mouse1.20871845
99STAT3_18555785_Chip-Seq_ESCs_Mouse1.20488642
100RUNX2_22187159_ChIP-Seq_PCA_Human1.20166585
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20008433
102ER_23166858_ChIP-Seq_MCF-7_Human1.18504383
103CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16532644
104SMAD_19615063_ChIP-ChIP_OVARY_Human1.15061073
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14868063
106SOX2_18555785_Chip-Seq_ESCs_Mouse1.14814957
107EZH2_27294783_Chip-Seq_NPCs_Mouse1.14608570
108SMC4_20622854_ChIP-Seq_HELA_Human1.13738234
109SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.13619757
110NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13499291
111P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13402205
112EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12799215
113EWS_26573619_Chip-Seq_HEK293_Human1.12785255
114RARB_27405468_Chip-Seq_BRAIN_Mouse1.11982073
115TAL1_26923725_Chip-Seq_HPCs_Mouse1.10922944
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10914046
117RUNX1_27457419_Chip-Seq_LIVER_Mouse1.10287932
118TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10017575
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09821700
120P300_18555785_Chip-Seq_ESCs_Mouse1.09419287
121EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09350198
122SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08544182
123MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07964959
124RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07686245
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07446823
126* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07408351
127RING1B_27294783_Chip-Seq_ESCs_Mouse1.06340932
128SOX2_21211035_ChIP-Seq_LN229_Gbm1.06306710
129TET1_21451524_ChIP-Seq_MESCs_Mouse1.05739971
130CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05220679
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05071627
132* P68_20966046_ChIP-Seq_HELA_Human1.04370971
133KDM2B_26808549_Chip-Seq_REH_Human1.04173272
134SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04161479
135OCT4_18555785_Chip-Seq_ESCs_Mouse1.04138023
136VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03811689
137CREB1_26743006_Chip-Seq_LNCaP_Human1.02142596
138KDM2B_26808549_Chip-Seq_DND41_Human1.01819940
139WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00211462
140* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.97821274
141* OCT4_19829295_ChIP-Seq_ESCs_Human0.97170291
142SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.93505261
143SOX3_22085726_ChIP-Seq_NPCs_Mouse0.92486882
144POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92428181
145* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92176225
146AR_19668381_ChIP-Seq_PC3_Human0.90536752
147NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90525342
148POU5F1_16518401_ChIP-PET_MESCs_Mouse0.90405854
149* DPY_21335234_ChIP-Seq_ESCs_Mouse0.89737270
150SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89335008
151KDM2B_26808549_Chip-Seq_JURKAT_Human0.88607153
152ISL1_27105846_Chip-Seq_CPCs_Mouse0.81835195
153NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.81441368
154PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.79949467
155* KLF4_19829295_ChIP-Seq_ESCs_Human0.79152319
156* SA1_27219007_Chip-Seq_ERYTHROID_Human0.78285824
157KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.77618893
158STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.76395193
159ESR2_21235772_ChIP-Seq_MCF-7_Human0.75410032
160CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.75200629
161MYC_27129775_Chip-Seq_CORNEA_Mouse0.75079115
162RUNX1_26923725_Chip-Seq_HPCs_Mouse0.74869787
163SA1_27219007_Chip-Seq_Bcells_Human0.73821742
164GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72952776
165PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.72730796
166NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.71085257

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.39301253
2MP0003880_abnormal_central_pattern4.11626009
3MP0005645_abnormal_hypothalamus_physiol3.16678840
4MP0005423_abnormal_somatic_nervous3.10163823
5MP0003635_abnormal_synaptic_transmissio3.05001868
6MP0006292_abnormal_olfactory_placode3.00312385
7MP0001968_abnormal_touch/_nociception2.80890199
8MP0005646_abnormal_pituitary_gland2.77854620
9MP0009745_abnormal_behavioral_response2.68930233
10MP0002063_abnormal_learning/memory/cond2.53807215
11MP0001486_abnormal_startle_reflex2.47039407
12MP0002572_abnormal_emotion/affect_behav2.42987743
13MP0001188_hyperpigmentation2.40144988
14MP0002735_abnormal_chemical_nociception2.37733612
15MP0004270_analgesia2.36096431
16MP0002734_abnormal_mechanical_nocicepti2.35025102
17MP0002736_abnormal_nociception_after2.30332662
18MP0002064_seizures2.29866631
19MP0006276_abnormal_autonomic_nervous2.25378336
20MP0010386_abnormal_urinary_bladder2.24855287
21MP0009046_muscle_twitch2.20866605
22MP0002876_abnormal_thyroid_physiology2.12018351
23MP0003123_paternal_imprinting2.03791350
24MP0001502_abnormal_circadian_rhythm2.00189674
25MP0003787_abnormal_imprinting1.99687639
26MP0002272_abnormal_nervous_system1.98754314
27MP0003329_amyloid_beta_deposits1.97882881
28MP0001440_abnormal_grooming_behavior1.95525017
29MP0002557_abnormal_social/conspecific_i1.88844933
30MP0002638_abnormal_pupillary_reflex1.85640905
31MP0002067_abnormal_sensory_capabilities1.85156340
32MP0001984_abnormal_olfaction1.84660445
33MP0000778_abnormal_nervous_system1.80751518
34MP0003122_maternal_imprinting1.75524960
35MP0004742_abnormal_vestibular_system1.75424092
36MP0001501_abnormal_sleep_pattern1.75276360
37MP0002184_abnormal_innervation1.75123709
38MP0002733_abnormal_thermal_nociception1.67558146
39MP0001986_abnormal_taste_sensitivity1.63469551
40MP0005379_endocrine/exocrine_gland_phen1.62923864
41MP0001970_abnormal_pain_threshold1.60181690
42MP0009697_abnormal_copulation1.59149049
43MP0000566_synostosis1.55492579
44MP0005171_absent_coat_pigmentation1.53152131
45MP0003879_abnormal_hair_cell1.51108462
46MP0004924_abnormal_behavior1.45058172
47MP0005386_behavior/neurological_phenoty1.45058172
48MP0002163_abnormal_gland_morphology1.44396129
49MP0000631_abnormal_neuroendocrine_gland1.40876400
50MP0009780_abnormal_chondrocyte_physiolo1.37796536
51MP0000678_abnormal_parathyroid_gland1.31157384
52MP0010030_abnormal_orbit_morphology1.31140955
53MP0002909_abnormal_adrenal_gland1.23926881
54MP0004811_abnormal_neuron_physiology1.22760735
55MP0003283_abnormal_digestive_organ1.22440120
56MP0004133_heterotaxia1.19513388
57MP0003861_abnormal_nervous_system1.19111005
58MP0000955_abnormal_spinal_cord1.18793652
59MP0008569_lethality_at_weaning1.17077313
60MP0000681_abnormal_thyroid_gland1.15237421
61MP0001529_abnormal_vocalization1.14338594
62MP0001905_abnormal_dopamine_level1.13595087
63MP0000579_abnormal_nail_morphology1.13334834
64MP0005257_abnormal_intraocular_pressure1.12901525
65MP0003938_abnormal_ear_development1.12798516
66MP0002066_abnormal_motor_capabilities/c1.10844644
67MP0002882_abnormal_neuron_morphology1.10654510
68MP0001963_abnormal_hearing_physiology1.08596729
69MP0002102_abnormal_ear_morphology1.07921197
70MP0000537_abnormal_urethra_morphology1.05307869
71MP0002249_abnormal_larynx_morphology1.05033260
72MP0004885_abnormal_endolymph1.03923341
73MP0002822_catalepsy1.02208829
74MP0004142_abnormal_muscle_tone1.00216345
75MP0002693_abnormal_pancreas_physiology0.97068299
76MP0000026_abnormal_inner_ear0.96672108
77MP0004858_abnormal_nervous_system0.95986775
78MP0003121_genomic_imprinting0.95669986
79MP0000015_abnormal_ear_pigmentation0.95645422
80MP0001299_abnormal_eye_distance/0.94868865
81MP0005551_abnormal_eye_electrophysiolog0.94458792
82MP0003634_abnormal_glial_cell0.92684709
83MP0001664_abnormal_digestion0.92446164
84MP0001177_atelectasis0.90010832
85MP0005623_abnormal_meninges_morphology0.89945034
86MP0001348_abnormal_lacrimal_gland0.89580601
87MP0000569_abnormal_digit_pigmentation0.88761101
88MP0003631_nervous_system_phenotype0.88628974
89MP0002069_abnormal_eating/drinking_beha0.88559193
90MP0005394_taste/olfaction_phenotype0.86655587
91MP0005499_abnormal_olfactory_system0.86655587
92MP0001346_abnormal_lacrimal_gland0.86417225
93MP0003878_abnormal_ear_physiology0.85205270
94MP0005377_hearing/vestibular/ear_phenot0.85205270
95MP0003633_abnormal_nervous_system0.84613813
96MP0003119_abnormal_digestive_system0.83988542
97MP0002751_abnormal_autonomic_nervous0.82801338
98MP0002152_abnormal_brain_morphology0.81122919
99MP0001485_abnormal_pinna_reflex0.80183628
100MP0005310_abnormal_salivary_gland0.80133223
101MP0002089_abnormal_postnatal_growth/wei0.79841483
102MP0006072_abnormal_retinal_apoptosis0.77934710
103MP0003942_abnormal_urinary_system0.77701341
104MP0003315_abnormal_perineum_morphology0.77476034
105MP0008877_abnormal_DNA_methylation0.77267445
106MP0000049_abnormal_middle_ear0.76858591
107MP0005187_abnormal_penis_morphology0.75291976
108MP0002277_abnormal_respiratory_mucosa0.75010131
109MP0002081_perinatal_lethality0.74721324
110MP0005253_abnormal_eye_physiology0.74120954
111MP0002752_abnormal_somatic_nervous0.73182399
112MP0005248_abnormal_Harderian_gland0.72526548
113MP0003868_abnormal_feces_composition0.71692874
114MP0004085_abnormal_heartbeat0.70683145
115MP0003890_abnormal_embryonic-extraembry0.70256959
116MP0004043_abnormal_pH_regulation0.69616503
117MP0000538_abnormal_urinary_bladder0.68470148
118MP0003183_abnormal_peptide_metabolism0.68413836
119MP0008004_abnormal_stomach_pH0.68333276
120MP0003385_abnormal_body_wall0.68206130
121MP0002653_abnormal_ependyma_morphology0.67738517
122MP0003690_abnormal_glial_cell0.67487243
123MP0008789_abnormal_olfactory_epithelium0.66120604
124MP0002229_neurodegeneration0.65959115
125MP0010769_abnormal_survival0.65785739
126MP0010770_preweaning_lethality0.64024341
127MP0002082_postnatal_lethality0.64024341
128MP0004130_abnormal_muscle_cell0.63882576
129MP0005535_abnormal_body_temperature0.63500713
130MP0005409_darkened_coat_color0.63328824
131MP0003136_yellow_coat_color0.63241683
132MP0000372_irregular_coat_pigmentation0.63180033
133MP0001943_abnormal_respiration0.62902316
134MP0000462_abnormal_digestive_system0.61750279
135MP0010768_mortality/aging0.61453573
136MP0002233_abnormal_nose_morphology0.61112363
137MP0009672_abnormal_birth_weight0.60754318

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.20082630
2Febrile seizures (HP:0002373)5.25497258
3Epileptic encephalopathy (HP:0200134)4.20347830
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.09955829
5Absent/shortened dynein arms (HP:0200106)4.09955829
6Supranuclear gaze palsy (HP:0000605)4.06401214
7Action tremor (HP:0002345)3.95687968
8Focal seizures (HP:0007359)3.66765741
9Abnormal ciliary motility (HP:0012262)3.57306724
10Torticollis (HP:0000473)3.43263046
11Neurofibrillary tangles (HP:0002185)3.36673823
12Myokymia (HP:0002411)3.23825718
13Urinary bladder sphincter dysfunction (HP:0002839)3.19290268
14Abnormality of binocular vision (HP:0011514)3.14292269
15Diplopia (HP:0000651)3.14292269
16Visual hallucinations (HP:0002367)3.13900192
17Atonic seizures (HP:0010819)3.11054987
18Absent eyebrow (HP:0002223)3.07253370
19Hyperventilation (HP:0002883)2.98479873
20Spastic gait (HP:0002064)2.94482925
21Abnormal respiratory motile cilium morphology (HP:0005938)2.92711596
22Abnormal respiratory epithelium morphology (HP:0012253)2.92711596
23Unilateral renal agenesis (HP:0000122)2.92058788
24Turricephaly (HP:0000262)2.91254964
25Insomnia (HP:0100785)2.90147350
26Cerebral inclusion bodies (HP:0100314)2.89355741
27Focal dystonia (HP:0004373)2.88071758
28Impaired vibration sensation in the lower limbs (HP:0002166)2.87939463
29Progressive cerebellar ataxia (HP:0002073)2.85409449
30Abnormal respiratory motile cilium physiology (HP:0012261)2.85043064
31Absence seizures (HP:0002121)2.84840238
32Abnormality of calcium-phosphate metabolism (HP:0100530)2.82327178
33Osteomalacia (HP:0002749)2.82266330
34Hypothermia (HP:0002045)2.81237534
35Generalized tonic-clonic seizures (HP:0002069)2.79436224
36Abnormality of dental color (HP:0011073)2.73924666
37Broad-based gait (HP:0002136)2.72127829
38Abnormality of the lower motor neuron (HP:0002366)2.70476282
39Dialeptic seizures (HP:0011146)2.69260853
40Decreased circulating renin level (HP:0003351)2.65181639
41Obstructive sleep apnea (HP:0002870)2.61572967
42Craniofacial dystonia (HP:0012179)2.60746770
43Parakeratosis (HP:0001036)2.60224386
44Urinary urgency (HP:0000012)2.59452053
45Polyphagia (HP:0002591)2.58119356
46Depression (HP:0000716)2.57414748
47Dysmetria (HP:0001310)2.54299300
48Gaze-evoked nystagmus (HP:0000640)2.54257036
49Generalized hypopigmentation of hair (HP:0011358)2.54084678
50Aplasia involving bones of the extremities (HP:0009825)2.53759155
51Aplasia involving bones of the upper limbs (HP:0009823)2.53759155
52Aplasia of the phalanges of the hand (HP:0009802)2.53759155
53Chronic hepatic failure (HP:0100626)2.53364981
54Annular pancreas (HP:0001734)2.52529079
55Excessive salivation (HP:0003781)2.49596059
56Drooling (HP:0002307)2.49596059
57Mutism (HP:0002300)2.47670987
58Hypoglycemic seizures (HP:0002173)2.46612089
59Agitation (HP:0000713)2.46406347
60Failure to thrive in infancy (HP:0001531)2.43444331
61Symptomatic seizures (HP:0011145)2.42137270
62Protruding tongue (HP:0010808)2.37809043
63Fair hair (HP:0002286)2.33969311
64Blue irides (HP:0000635)2.33005949
65Absent speech (HP:0001344)2.32906533
66Abnormal eating behavior (HP:0100738)2.32872799
67Hyperphosphatemia (HP:0002905)2.29006712
68Postural instability (HP:0002172)2.29000832
69Hyperacusis (HP:0010780)2.28109481
70Limb dystonia (HP:0002451)2.28050929
71Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.28027050
72Abnormal social behavior (HP:0012433)2.27806575
73Impaired social interactions (HP:0000735)2.27806575
74Overriding aorta (HP:0002623)2.27130071
75Epileptiform EEG discharges (HP:0011182)2.26915460
76Megalencephaly (HP:0001355)2.26370091
77Bronchomalacia (HP:0002780)2.26031229
78Fetal akinesia sequence (HP:0001989)2.25843326
79Septo-optic dysplasia (HP:0100842)2.25071040
80Medial flaring of the eyebrow (HP:0010747)2.24571503
81Split foot (HP:0001839)2.22167738
82Apathy (HP:0000741)2.22163372
83Widely spaced teeth (HP:0000687)2.21020557
84Pointed chin (HP:0000307)2.20361058
85Anosmia (HP:0000458)2.17187137
86EEG with generalized epileptiform discharges (HP:0011198)2.17161768
87Gait imbalance (HP:0002141)2.15048011
88True hermaphroditism (HP:0010459)2.09179842
89Cerebral hypomyelination (HP:0006808)2.09161996
90Neuronal loss in central nervous system (HP:0002529)2.08977512
91Exotropia (HP:0000577)2.04229641
92Hyperthyroidism (HP:0000836)2.03063415
93Inability to walk (HP:0002540)2.02440149
94Status epilepticus (HP:0002133)2.01085255
95Diminished motivation (HP:0000745)2.00916261
96Hypsarrhythmia (HP:0002521)2.00142598
97Bradykinesia (HP:0002067)1.99327469
98Molar tooth sign on MRI (HP:0002419)1.97867772
99Abnormality of midbrain morphology (HP:0002418)1.97867772
100Nephronophthisis (HP:0000090)1.97421212
101Clonus (HP:0002169)1.95906214
102Abnormality of the corticospinal tract (HP:0002492)1.95408416
103Elfin facies (HP:0004428)1.95086985
104Optic nerve hypoplasia (HP:0000609)1.94262459
105Ankle clonus (HP:0011448)1.93404902
106Spastic tetraparesis (HP:0001285)1.93211521
107Incomplete penetrance (HP:0003829)1.93164561
108Intention tremor (HP:0002080)1.91766088
109Nephrogenic diabetes insipidus (HP:0009806)1.91713336
110Abnormal hair whorl (HP:0010721)1.91664635
111Cutaneous syndactyly (HP:0012725)1.90479810
112Absent eyelashes (HP:0000561)1.90090614
113Delusions (HP:0000746)1.88475098
114Lower limb muscle weakness (HP:0007340)1.88104397
115Hyperaldosteronism (HP:0000859)1.87899040
116Hypoplasia of the fovea (HP:0007750)1.87577942
117Aplasia/Hypoplasia of the fovea (HP:0008060)1.87577942
118Esotropia (HP:0000565)1.87149266
119Tetraplegia (HP:0002445)1.86942525
120Abnormality of salivation (HP:0100755)1.84597487
121Stereotypic behavior (HP:0000733)1.83631373
122Progressive inability to walk (HP:0002505)1.83171524
123Decreased central vision (HP:0007663)1.83148161
124High anterior hairline (HP:0009890)1.82903831
125Anxiety (HP:0000739)1.81773626
126Abnormality of renin-angiotensin system (HP:0000847)1.81513816
127Truncal ataxia (HP:0002078)1.79357151
128Abnormality of the aortic arch (HP:0012303)1.79250085
129Akinesia (HP:0002304)1.78646567
130Congenital primary aphakia (HP:0007707)1.78262200
131Chromosomal breakage induced by crosslinking agents (HP:0003221)1.75363483
132Hemiparesis (HP:0001269)1.75338198
133Bradycardia (HP:0001662)1.74420067
134Amblyopia (HP:0000646)1.74063499
135Abnormality of the fovea (HP:0000493)1.73563300
136Conjugated hyperbilirubinemia (HP:0002908)1.73374848
137Nonprogressive disorder (HP:0003680)1.72832727
138Hand muscle atrophy (HP:0009130)1.72563198
139Morphological abnormality of the pyramidal tract (HP:0002062)1.72326336
140Renal duplication (HP:0000075)1.72065952
141Sleep apnea (HP:0010535)1.72045386
142Congenital sensorineural hearing impairment (HP:0008527)1.71804490
143Lower limb amyotrophy (HP:0007210)1.71653649
144Poor eye contact (HP:0000817)1.71177374
145Hypoventilation (HP:0002791)1.70505335
146Pancreatic fibrosis (HP:0100732)1.70394628
147Inappropriate behavior (HP:0000719)1.69894717
148Abnormal EKG (HP:0003115)1.69273991
149Truncus arteriosus (HP:0001660)1.69111517
150Hyperactive renin-angiotensin system (HP:0000841)1.68768626
151Hemiplegia (HP:0002301)1.68583618
152Poor suck (HP:0002033)1.67331505
153Gastroesophageal reflux (HP:0002020)1.67216976
154Tetany (HP:0001281)1.67038134
155Papilledema (HP:0001085)1.66838644
156Absent hair (HP:0002298)1.66399386
157Rhinitis (HP:0012384)1.66339291
158Partial duplication of thumb phalanx (HP:0009944)1.65909775
159Trigonocephaly (HP:0000243)1.65625614
160Megalocornea (HP:0000485)1.65442779
161Lower limb asymmetry (HP:0100559)1.64342366
162Choanal stenosis (HP:0000452)1.63964294
163Abnormality of the renal medulla (HP:0100957)1.63715023
164Median cleft lip (HP:0000161)1.61969318
165Hypoplasia of the brainstem (HP:0002365)1.61262656
166Aplasia/Hypoplasia of the brainstem (HP:0007362)1.61262656
167Impaired vibratory sensation (HP:0002495)1.60955401
168Cutaneous finger syndactyly (HP:0010554)1.60396484
169Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.59951141

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.94841277
2INSRR3.43829502
3CASK3.32895444
4SIK33.18966872
5MAP2K73.12189659
6MARK12.87842988
7EPHA42.86180260
8TNIK2.64046801
9MAP3K42.39457532
10MAP3K122.38919768
11TYRO32.32683411
12LATS22.26726533
13PRPF4B2.21901241
14NTRK22.15798661
15MAPK131.87037433
16SIK21.85773426
17AKT31.84772251
18MUSK1.81707455
19IRAK21.76529083
20DAPK21.75859739
21DYRK21.65405600
22TNK21.62551278
23MINK11.58941547
24ZAK1.56211261
25RIPK11.54060669
26BMPR21.50512877
27PRKD31.44991458
28SGK21.33143827
29ADRBK21.32993819
30MAP2K41.27989590
31MAP3K91.22710021
32NME11.21325771
33ARAF1.20592581
34BMPR1B1.17950491
35IRAK31.16043781
36NEK61.15876522
37CDK151.12113102
38LMTK21.10644055
39CDK51.10136293
40CDK181.09141028
41TXK1.08351963
42SGK2231.08289355
43SGK4941.08289355
44ERBB31.06627089
45CDK11A1.05792157
46CDK31.05700243
47PLK21.04677847
48DAPK11.01120166
49WNK31.00638602
50PRKCG1.00563181
51CDK140.99698445
52STK380.99496363
53FGFR20.96605189
54CAMK2A0.96553482
55BRSK10.92683578
56CAMKK10.91828873
57DYRK1A0.88930173
58GRK70.88480529
59ICK0.87834006
60UHMK10.87416589
61PRKCE0.84394242
62ALK0.82918740
63MAP3K60.82137225
64TRIB30.80458781
65EPHA30.79093686
66BCR0.78994800
67LIMK10.78838719
68GRK50.78155071
69EEF2K0.77314700
70PINK10.76621149
71PAK60.74892848
72EPHB20.73986858
73CAMK1G0.73976548
74CDK80.73740801
75SGK10.72592072
76MAPKAPK50.72542846
77SGK30.71931460
78CAMKK20.71642795
79STK160.71572994
80PAK30.70767524
81IRAK40.69754085
82RIPK40.68572796
83TESK10.68163696
84CAMK1D0.67370871
85MARK20.67120672
86SMG10.65863283
87IRAK10.65382803
88MKNK20.64823831
89PNCK0.64792239
90CAMK2B0.64067621
91STK110.63370613
92CDK190.62325112
93YES10.61806128
94SRPK10.59617318
95BRAF0.58780638
96PRKCZ0.58286357
97DAPK30.58108436
98MAPK120.58052691
99CAMK10.56719514
100PKN10.55903098
101KSR20.53752288
102MAP3K110.53340066
103PASK0.53313857
104FES0.52547255
105TAOK20.51842137
106HIPK20.51324887
107MAPK100.49735169
108KSR10.48916202
109CAMK2G0.47800960
110RPS6KA20.46970218
111CSNK1E0.46660000
112CSNK1G30.44658276
113PHKG20.44570153
114PHKG10.44570153
115RPS6KA30.43443948
116CDC42BPA0.43272361
117OXSR10.43138604
118DMPK0.42054100
119NTRK10.41720751
120EIF2AK20.41076160
121BMX0.39943054
122CSNK1G20.39440998
123RPS6KB10.39284044
124CSNK1A1L0.39215315
125AURKA0.38994385
126MAP2K60.38824757
127FER0.38069440
128PRKCH0.37830712
129GRK10.37020597
130FGR0.35928351
131MKNK10.35914007
132ERBB20.35764328
133PRKG10.35439138
134ROCK20.34565323
135PRKACA0.34267500
136MAPK150.33725449
137PDGFRA0.33356795
138CSNK1A10.33344296
139PRKG20.33255520
140CAMK2D0.33142245
141MAPK80.32778883
142GSK3B0.32393346
143CAMK40.32174432
144CSNK1D0.31944408
145WNK10.30386852
146PRKCI0.29493863
147PTK20.29227131
148RET0.26491067
149CSNK1G10.25184950

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.14068365
2Synaptic vesicle cycle_Homo sapiens_hsa047213.02918898
3Morphine addiction_Homo sapiens_hsa050322.67768791
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.65540218
5Olfactory transduction_Homo sapiens_hsa047402.47485429
6GABAergic synapse_Homo sapiens_hsa047272.47104678
7Circadian entrainment_Homo sapiens_hsa047132.43932851
8Glutamatergic synapse_Homo sapiens_hsa047242.32774302
9Insulin secretion_Homo sapiens_hsa049112.32125268
10Taste transduction_Homo sapiens_hsa047422.32023566
11Amphetamine addiction_Homo sapiens_hsa050312.14727707
12Collecting duct acid secretion_Homo sapiens_hsa049662.07400227
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.00128620
14Serotonergic synapse_Homo sapiens_hsa047261.96626468
15Long-term potentiation_Homo sapiens_hsa047201.95371256
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.92518000
17Dopaminergic synapse_Homo sapiens_hsa047281.74979388
18Cocaine addiction_Homo sapiens_hsa050301.70215497
19Vitamin B6 metabolism_Homo sapiens_hsa007501.64805488
20Cholinergic synapse_Homo sapiens_hsa047251.63957568
21Salivary secretion_Homo sapiens_hsa049701.61234955
22Calcium signaling pathway_Homo sapiens_hsa040201.57131567
23Renin secretion_Homo sapiens_hsa049241.49156150
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42816754
25Axon guidance_Homo sapiens_hsa043601.42529170
26Long-term depression_Homo sapiens_hsa047301.37875394
27Type II diabetes mellitus_Homo sapiens_hsa049301.33197157
28Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.33181736
29Vibrio cholerae infection_Homo sapiens_hsa051101.30299297
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.28083472
31Type I diabetes mellitus_Homo sapiens_hsa049401.25930357
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22006117
33Gastric acid secretion_Homo sapiens_hsa049711.19082540
34Basal cell carcinoma_Homo sapiens_hsa052171.15773521
35Oxytocin signaling pathway_Homo sapiens_hsa049211.13656846
36Hippo signaling pathway_Homo sapiens_hsa043901.13127431
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08732113
38cAMP signaling pathway_Homo sapiens_hsa040241.06669179
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06112748
40Circadian rhythm_Homo sapiens_hsa047101.05421954
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03116089
42Hedgehog signaling pathway_Homo sapiens_hsa043401.02696114
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01853954
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00161998
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98582888
46Sphingolipid metabolism_Homo sapiens_hsa006000.95485482
47Oocyte meiosis_Homo sapiens_hsa041140.94739345
48Phototransduction_Homo sapiens_hsa047440.94129891
49GnRH signaling pathway_Homo sapiens_hsa049120.93725278
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93622118
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93400927
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93030596
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90545473
54Rheumatoid arthritis_Homo sapiens_hsa053230.89055207
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88567501
56VEGF signaling pathway_Homo sapiens_hsa043700.86805724
57ErbB signaling pathway_Homo sapiens_hsa040120.86288290
58Gap junction_Homo sapiens_hsa045400.86105506
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.85388395
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79765601
61Ovarian steroidogenesis_Homo sapiens_hsa049130.79022916
62Pancreatic secretion_Homo sapiens_hsa049720.77285869
63Protein export_Homo sapiens_hsa030600.77275414
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76788320
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.76201253
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75871293
67Melanogenesis_Homo sapiens_hsa049160.74211557
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72767839
69Estrogen signaling pathway_Homo sapiens_hsa049150.69593953
70Ras signaling pathway_Homo sapiens_hsa040140.68516599
71Tight junction_Homo sapiens_hsa045300.67536589
72Phagosome_Homo sapiens_hsa041450.67487400
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66818525
74MAPK signaling pathway_Homo sapiens_hsa040100.65104691
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62464290
76Inositol phosphate metabolism_Homo sapiens_hsa005620.61843444
77Alcoholism_Homo sapiens_hsa050340.61803426
78Autoimmune thyroid disease_Homo sapiens_hsa053200.60594634
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60455028
80Bile secretion_Homo sapiens_hsa049760.59902293
81Ether lipid metabolism_Homo sapiens_hsa005650.59793468
82Insulin signaling pathway_Homo sapiens_hsa049100.59174274
83Wnt signaling pathway_Homo sapiens_hsa043100.58837855
84Notch signaling pathway_Homo sapiens_hsa043300.57921790
85Endometrial cancer_Homo sapiens_hsa052130.56699676
86Graft-versus-host disease_Homo sapiens_hsa053320.55100807
87AMPK signaling pathway_Homo sapiens_hsa041520.54385871
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53822664
89Folate biosynthesis_Homo sapiens_hsa007900.53682191
90Mineral absorption_Homo sapiens_hsa049780.52714868
91Glioma_Homo sapiens_hsa052140.52677388
92Dorso-ventral axis formation_Homo sapiens_hsa043200.51487873
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50758071
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50101911
95African trypanosomiasis_Homo sapiens_hsa051430.49452049
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49303504
97Choline metabolism in cancer_Homo sapiens_hsa052310.49213746
98Arginine and proline metabolism_Homo sapiens_hsa003300.48706294
99Dilated cardiomyopathy_Homo sapiens_hsa054140.48540244
100N-Glycan biosynthesis_Homo sapiens_hsa005100.48165045
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47257262
102Endocytosis_Homo sapiens_hsa041440.46265113
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45942260
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.44293112
105Alzheimers disease_Homo sapiens_hsa050100.43966521
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43952595
107Cardiac muscle contraction_Homo sapiens_hsa042600.43086297
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41169663
109Melanoma_Homo sapiens_hsa052180.41039809
110Colorectal cancer_Homo sapiens_hsa052100.40258076
111Thyroid hormone synthesis_Homo sapiens_hsa049180.40176792
112Prion diseases_Homo sapiens_hsa050200.40082197
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39788693
114Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39615022
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38737672
116mRNA surveillance pathway_Homo sapiens_hsa030150.38497878
117Prolactin signaling pathway_Homo sapiens_hsa049170.37868262
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35802354
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.35646167
120Other glycan degradation_Homo sapiens_hsa005110.35156238
121Allograft rejection_Homo sapiens_hsa053300.34283573
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33972039
123Chemokine signaling pathway_Homo sapiens_hsa040620.33932922
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.33491976
125Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32509862
126Glucagon signaling pathway_Homo sapiens_hsa049220.32354901
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.30603552
128Rap1 signaling pathway_Homo sapiens_hsa040150.30588826
129mTOR signaling pathway_Homo sapiens_hsa041500.29928809
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26796032
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26704987

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