C22ORF29

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication checkpoint (GO:0000076)4.83172716
2meiotic chromosome segregation (GO:0045132)4.15716308
3somatic diversification of immune receptors via somatic mutation (GO:0002566)4.13129333
4somatic hypermutation of immunoglobulin genes (GO:0016446)4.13129333
5histone H2A acetylation (GO:0043968)4.11741872
6nuclear pore organization (GO:0006999)3.96259199
7synapsis (GO:0007129)3.91851250
8resolution of meiotic recombination intermediates (GO:0000712)3.86391911
9pseudouridine synthesis (GO:0001522)3.80601720
10mitotic nuclear envelope disassembly (GO:0007077)3.61644546
11nuclear pore complex assembly (GO:0051292)3.58310112
12regulation of centriole replication (GO:0046599)3.57448941
13DNA topological change (GO:0006265)3.54033659
14proteasome assembly (GO:0043248)3.45586890
15replication fork processing (GO:0031297)3.32943074
16DNA strand renaturation (GO:0000733)3.30748463
17mitotic sister chromatid segregation (GO:0000070)3.28955079
18amino acid activation (GO:0043038)3.28133336
19tRNA aminoacylation (GO:0043039)3.28133336
20membrane disassembly (GO:0030397)3.27246218
21nuclear envelope disassembly (GO:0051081)3.27246218
22DNA strand elongation involved in DNA replication (GO:0006271)3.25681130
23maturation of 5.8S rRNA (GO:0000460)3.22717327
24tRNA aminoacylation for protein translation (GO:0006418)3.22702240
25regulation of translational fidelity (GO:0006450)3.16434556
26DNA strand elongation (GO:0022616)3.15254706
27nucleobase biosynthetic process (GO:0046112)3.13952832
28sister chromatid segregation (GO:0000819)3.10800943
29DNA double-strand break processing (GO:0000729)3.06749060
30DNA replication initiation (GO:0006270)3.05786361
31telomere maintenance via semi-conservative replication (GO:0032201)3.04749278
32regulation of centrosome cycle (GO:0046605)3.02197065
33attachment of spindle microtubules to kinetochore (GO:0008608)2.97649383
34kinetochore organization (GO:0051383)2.96764414
35pore complex assembly (GO:0046931)2.92286915
36purine nucleobase biosynthetic process (GO:0009113)2.91877278
37kinetochore assembly (GO:0051382)2.90857925
38double-strand break repair via homologous recombination (GO:0000724)2.87731747
39peptidyl-histidine modification (GO:0018202)2.86842056
40recombinational repair (GO:0000725)2.86258529
41maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.84153219
42mismatch repair (GO:0006298)2.83597602
43regulation of centrosome duplication (GO:0010824)2.83320099
44mRNA cleavage (GO:0006379)2.82335944
45tRNA modification (GO:0006400)2.80039100
46negative regulation of translation, ncRNA-mediated (GO:0040033)2.79287834
47regulation of translation, ncRNA-mediated (GO:0045974)2.79287834
48negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.79287834
49tRNA metabolic process (GO:0006399)2.77498308
50biotin metabolic process (GO:0006768)2.76807186
51regulation of histone H3-K4 methylation (GO:0051569)2.74131688
52DNA catabolic process, exonucleolytic (GO:0000738)2.73151839
53mitotic metaphase plate congression (GO:0007080)2.72741736
54respiratory chain complex IV assembly (GO:0008535)2.72011391
55metaphase plate congression (GO:0051310)2.71140662
56telomere maintenance via recombination (GO:0000722)2.69386597
57L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.69088026
58mitochondrial RNA metabolic process (GO:0000959)2.68813422
59mitotic recombination (GO:0006312)2.66946486
60RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.66368531
61tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.66368531
62mannosylation (GO:0097502)2.65701996
63lactate metabolic process (GO:0006089)2.65666777
64RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.65320196
65nucleotide-excision repair, DNA gap filling (GO:0006297)2.64304759
66branched-chain amino acid catabolic process (GO:0009083)2.63622822
67tRNA processing (GO:0008033)2.63607284
68regulation of nuclear cell cycle DNA replication (GO:0033262)2.62785137
69aspartate family amino acid biosynthetic process (GO:0009067)2.62318609
70non-recombinational repair (GO:0000726)2.61704570
71double-strand break repair via nonhomologous end joining (GO:0006303)2.61704570
72transcription elongation from RNA polymerase III promoter (GO:0006385)2.61130336
73termination of RNA polymerase III transcription (GO:0006386)2.61130336
74intra-S DNA damage checkpoint (GO:0031573)2.59944183
75folic acid metabolic process (GO:0046655)2.59333380
76L-serine metabolic process (GO:0006563)2.57695493
77nuclear envelope organization (GO:0006998)2.57636093
78ncRNA 3-end processing (GO:0043628)2.56475093
79regulation of mitochondrial translation (GO:0070129)2.56308599
80DNA recombination (GO:0006310)2.55290741
81postreplication repair (GO:0006301)2.54544370
82DNA ligation (GO:0006266)2.52493005
83methionine biosynthetic process (GO:0009086)2.50937277
84telomere maintenance via telomere lengthening (GO:0010833)2.50912381
85chromosome segregation (GO:0007059)2.49885396
86base-excision repair (GO:0006284)2.49607530
87homocysteine metabolic process (GO:0050667)2.49357031
88folic acid-containing compound biosynthetic process (GO:0009396)2.48236063
89base-excision repair, AP site formation (GO:0006285)2.47250348
90regulation of mitotic spindle checkpoint (GO:1903504)2.46408420
91regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.46408420
92dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.46269487
93cytochrome complex assembly (GO:0017004)2.44704989
94DNA methylation involved in gamete generation (GO:0043046)2.44693660
95terpenoid biosynthetic process (GO:0016114)2.44220767
96viral mRNA export from host cell nucleus (GO:0046784)2.42169383
97centriole replication (GO:0007099)2.42141060
98snRNA processing (GO:0016180)2.41966454
99positive regulation of megakaryocyte differentiation (GO:0045654)2.41464700
100rRNA modification (GO:0000154)2.41208999

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.69117183
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.42440451
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.58982637
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.52246871
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.51774575
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.46876948
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.25659501
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.24112556
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.17206959
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.07077772
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.76985870
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.76542984
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.68089179
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.53369226
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.47621934
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.42720053
17* DCP1A_22483619_ChIP-Seq_HELA_Human2.41071654
18GABP_19822575_ChIP-Seq_HepG2_Human2.30326511
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.28913041
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.28755839
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.25439672
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.25261718
23XRN2_22483619_ChIP-Seq_HELA_Human2.24967167
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.22237577
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.19416829
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.17588497
27ZNF274_21170338_ChIP-Seq_K562_Hela2.16357660
28VDR_23849224_ChIP-Seq_CD4+_Human2.13938684
29KDM5A_27292631_Chip-Seq_BREAST_Human2.10851172
30ELK1_19687146_ChIP-ChIP_HELA_Human2.09020628
31FOXP3_21729870_ChIP-Seq_TREG_Human2.07427486
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97315072
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96116925
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.91330816
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.87939428
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.87559580
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87070159
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.86448347
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.86267938
40TTF2_22483619_ChIP-Seq_HELA_Human1.82297218
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79707753
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.78889013
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77341407
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.73572325
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.73235147
46CIITA_25753668_ChIP-Seq_RAJI_Human1.67211869
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66079239
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63910109
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.61474005
50MYC_18940864_ChIP-ChIP_HL60_Human1.59332816
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.53747525
52E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.53460341
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40801826
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40768902
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.37669770
56CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.36430056
57AR_21909140_ChIP-Seq_LNCAP_Human1.35213727
58BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.31483862
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.30942270
60EWS_26573619_Chip-Seq_HEK293_Human1.29151915
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28329116
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26288328
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21900751
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18804115
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15939496
66DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13073136
67CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09766403
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08422402
69FOXP1_21924763_ChIP-Seq_HESCs_Human1.05859202
70CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04547332
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99843950
72ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99458085
73TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98657449
74* NCOR1_26117541_ChIP-Seq_K562_Human0.93855133
75SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93432557
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88984832
77GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88687433
78VDR_22108803_ChIP-Seq_LS180_Human0.88394426
79ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88260023
80HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87375899
81CHD1_26751641_Chip-Seq_LNCaP_Human0.85003211
82ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84941797
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82260340
84KLF4_18555785_ChIP-Seq_MESCs_Mouse0.82197116
85TFEB_21752829_ChIP-Seq_HELA_Human0.81232089
86HIF1A_21447827_ChIP-Seq_MCF-7_Human0.79632491
87PKCTHETA_26484144_Chip-Seq_BREAST_Human0.77123417
88SOX2_16153702_ChIP-ChIP_HESCs_Human0.76784703
89CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.76128878
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.75265591
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.74991912
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72049478
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.71643692
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.71033777
95FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70459972
96SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.70050230
97PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.69470359
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.68626254
99TP53_22573176_ChIP-Seq_HFKS_Human0.68226986
100MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.66180832

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.83087340
2MP0008058_abnormal_DNA_repair3.65995417
3MP0003111_abnormal_nucleus_morphology3.53450489
4MP0003693_abnormal_embryo_hatching3.08143471
5MP0003786_premature_aging2.92141714
6MP0008995_early_reproductive_senescence2.57096545
7MP0004147_increased_porphyrin_level2.39679831
8MP0004957_abnormal_blastocyst_morpholog2.34428936
9MP0008057_abnormal_DNA_replication2.27014610
10MP0008932_abnormal_embryonic_tissue2.16187024
11MP0008877_abnormal_DNA_methylation2.15730687
12MP0000372_irregular_coat_pigmentation2.05066640
13MP0003077_abnormal_cell_cycle2.04620503
14MP0008007_abnormal_cellular_replicative2.03317775
15MP0006292_abnormal_olfactory_placode1.99391791
16MP0001529_abnormal_vocalization1.95494080
17MP0003718_maternal_effect1.87413509
18MP0002938_white_spotting1.81101159
19MP0002234_abnormal_pharynx_morphology1.79933932
20MP0005083_abnormal_biliary_tract1.74158868
21MP0009697_abnormal_copulation1.72022327
22MP0008789_abnormal_olfactory_epithelium1.61981586
23MP0002160_abnormal_reproductive_system1.50121671
24MP0005367_renal/urinary_system_phenotyp1.49517761
25MP0000516_abnormal_urinary_system1.49517761
26MP0001764_abnormal_homeostasis1.27218468
27MP0003941_abnormal_skin_development1.24934308
28MP0002102_abnormal_ear_morphology1.23988403
29MP0001929_abnormal_gametogenesis1.21168510
30MP0004233_abnormal_muscle_weight1.20740938
31MP0003937_abnormal_limbs/digits/tail_de1.18881742
32MP0010307_abnormal_tumor_latency1.18870482
33MP0006035_abnormal_mitochondrial_morpho1.18622122
34MP0005394_taste/olfaction_phenotype1.17140576
35MP0005499_abnormal_olfactory_system1.17140576
36MP0002210_abnormal_sex_determination1.16602163
37MP0000678_abnormal_parathyroid_gland1.15850292
38MP0000647_abnormal_sebaceous_gland1.15039559
39MP0000358_abnormal_cell_content/1.13021279
40MP0000462_abnormal_digestive_system1.11140839
41MP0001697_abnormal_embryo_size1.10935794
42MP0001661_extended_life_span1.08461991
43MP0005075_abnormal_melanosome_morpholog1.06177888
44MP0001672_abnormal_embryogenesis/_devel1.02900781
45MP0005380_embryogenesis_phenotype1.02900781
46MP0008875_abnormal_xenobiotic_pharmacok1.00876165
47MP0001145_abnormal_male_reproductive1.00806395
48MP0005174_abnormal_tail_pigmentation1.00023604
49MP0000350_abnormal_cell_proliferation0.99515000
50MP0001293_anophthalmia0.99301629
51MP0000653_abnormal_sex_gland0.98811271
52MP0010030_abnormal_orbit_morphology0.97141362
53MP0005646_abnormal_pituitary_gland0.96859178
54MP0000538_abnormal_urinary_bladder0.96720483
55MP0002396_abnormal_hematopoietic_system0.95964506
56MP0005220_abnormal_exocrine_pancreas0.95793126
57MP0008872_abnormal_physiological_respon0.95686377
58MP0003136_yellow_coat_color0.95336169
59MP0002085_abnormal_embryonic_tissue0.94802928
60MP0003755_abnormal_palate_morphology0.93760326
61MP0002080_prenatal_lethality0.93510251
62MP0003984_embryonic_growth_retardation0.93184791
63MP0002233_abnormal_nose_morphology0.92437321
64MP0002084_abnormal_developmental_patter0.91970272
65MP0004197_abnormal_fetal_growth/weight/0.91905377
66MP0004133_heterotaxia0.91419470
67MP0005171_absent_coat_pigmentation0.91284641
68MP0002088_abnormal_embryonic_growth/wei0.91216140
69MP0005332_abnormal_amino_acid0.90488571
70MP0003698_abnormal_male_reproductive0.90380799
71MP0001984_abnormal_olfaction0.89707210
72MP0005645_abnormal_hypothalamus_physiol0.88900735
73MP0003942_abnormal_urinary_system0.87749377
74MP0003195_calcinosis0.87125915
75MP0006036_abnormal_mitochondrial_physio0.86320326
76MP0003935_abnormal_craniofacial_develop0.84552170
77MP0002132_abnormal_respiratory_system0.83943304
78MP0004381_abnormal_hair_follicle0.83302349
79MP0000313_abnormal_cell_death0.82910973
80MP0000467_abnormal_esophagus_morphology0.82876712
81MP0001188_hyperpigmentation0.82153210
82MP0003385_abnormal_body_wall0.81432832
83MP0000631_abnormal_neuroendocrine_gland0.81355030
84MP0002163_abnormal_gland_morphology0.81272596
85MP0005389_reproductive_system_phenotype0.80316367
86MP0003122_maternal_imprinting0.80270098
87MP0005395_other_phenotype0.80108085
88MP0001119_abnormal_female_reproductive0.79232922
89MP0001730_embryonic_growth_arrest0.78990729
90MP0003119_abnormal_digestive_system0.78290418
91MP0003121_genomic_imprinting0.77014660
92MP0009703_decreased_birth_body0.76840135
93MP0001968_abnormal_touch/_nociception0.75320526
94MP0010234_abnormal_vibrissa_follicle0.74470450
95MP0002751_abnormal_autonomic_nervous0.72867207
96MP0002111_abnormal_tail_morphology0.72373287
97MP0000427_abnormal_hair_cycle0.72269899
98MP0005397_hematopoietic_system_phenotyp0.72116999
99MP0001545_abnormal_hematopoietic_system0.72116999
100MP0003950_abnormal_plasma_membrane0.71193485

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)3.80195647
2Chromsome breakage (HP:0040012)3.61947487
3Cholecystitis (HP:0001082)3.61621988
4Abnormal gallbladder physiology (HP:0012438)3.61621988
5Hyperthyroidism (HP:0000836)3.52193431
6Ependymoma (HP:0002888)3.38089762
7Birth length less than 3rd percentile (HP:0003561)3.28288879
8Poikiloderma (HP:0001029)3.25089419
9Truncus arteriosus (HP:0001660)3.24170966
10Type I transferrin isoform profile (HP:0003642)2.95835777
11Abnormality of DNA repair (HP:0003254)2.78543302
12Abnormality of the preputium (HP:0100587)2.76270193
13Squamous cell carcinoma (HP:0002860)2.75522103
14Aplasia/Hypoplasia of the uvula (HP:0010293)2.68934824
15Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.63790869
16Abnormal protein N-linked glycosylation (HP:0012347)2.63790869
17Abnormal protein glycosylation (HP:0012346)2.63790869
18Abnormal glycosylation (HP:0012345)2.63790869
19Abnormality of homocysteine metabolism (HP:0010919)2.53991562
20Homocystinuria (HP:0002156)2.53991562
21Abnormality of the astrocytes (HP:0100707)2.52614578
22Astrocytoma (HP:0009592)2.52614578
23Meckel diverticulum (HP:0002245)2.47452601
24Abnormality of the ileum (HP:0001549)2.46766270
25Abnormality of the labia minora (HP:0012880)2.46076139
26Duodenal stenosis (HP:0100867)2.44770992
27Small intestinal stenosis (HP:0012848)2.44770992
28Aplasia/Hypoplasia of the earlobes (HP:0009906)2.43498798
29Abnormality of chromosome stability (HP:0003220)2.42557045
30Abnormal mitochondria in muscle tissue (HP:0008316)2.40956023
31Acute encephalopathy (HP:0006846)2.36865579
32Patellar aplasia (HP:0006443)2.33067882
33Absent thumb (HP:0009777)2.32361486
34Acute necrotizing encephalopathy (HP:0006965)2.26602873
35Popliteal pterygium (HP:0009756)2.23933488
36Hypoplasia of the pons (HP:0012110)2.23920045
37Cerebellar dysplasia (HP:0007033)2.21761977
38Type II lissencephaly (HP:0007260)2.20455282
39Duplicated collecting system (HP:0000081)2.20373521
40Entropion (HP:0000621)2.19259914
41Glioma (HP:0009733)2.19102280
42Aplasia/Hypoplasia of the patella (HP:0006498)2.18938611
43Ectopic kidney (HP:0000086)2.18286527
44Sloping forehead (HP:0000340)2.15493729
45Methylmalonic acidemia (HP:0002912)2.11518263
46Increased CSF lactate (HP:0002490)2.09514553
47Microvesicular hepatic steatosis (HP:0001414)2.08349699
48Neoplasm of the adrenal cortex (HP:0100641)2.07843417
49Aplasia/Hypoplasia involving the musculature (HP:0001460)2.06990733
50Hypoplastic pelvis (HP:0008839)2.06672619
51Progressive macrocephaly (HP:0004481)2.03107032
52Hypertensive crisis (HP:0100735)2.00881528
53Abnormality of the duodenum (HP:0002246)1.98750284
54Seborrheic dermatitis (HP:0001051)1.97191844
55Methylmalonic aciduria (HP:0012120)1.94693258
56Abnormality of methionine metabolism (HP:0010901)1.93931016
57Abnormality of the pons (HP:0007361)1.91274663
58Pancreatic cysts (HP:0001737)1.90367371
59Abnormality of the carotid arteries (HP:0005344)1.89825829
60Colon cancer (HP:0003003)1.89203609
61Septate vagina (HP:0001153)1.89020980
62Abnormality of the renal collecting system (HP:0004742)1.88547160
63Mitochondrial inheritance (HP:0001427)1.88290391
64Abnormality of the parathyroid morphology (HP:0011766)1.86979150
65Type 2 muscle fiber atrophy (HP:0003554)1.86618458
66Dry hair (HP:0011359)1.86537049
67Abnormality of sulfur amino acid metabolism (HP:0004339)1.86491823
68Pancreatic fibrosis (HP:0100732)1.86220325
69Cerebral edema (HP:0002181)1.85508447
70Abnormality of glycolysis (HP:0004366)1.84841841
71Hepatocellular necrosis (HP:0001404)1.82079372
72Overfolded helix (HP:0000396)1.81532513
73Hepatic necrosis (HP:0002605)1.80820848
74Absent radius (HP:0003974)1.77802536
75Horseshoe kidney (HP:0000085)1.77211528
76Cerebral hypomyelination (HP:0006808)1.76342992
77Brushfield spots (HP:0001088)1.75847890
78Hypoparathyroidism (HP:0000829)1.75755182
79Adenoma sebaceum (HP:0009720)1.75687425
80Angiofibromas (HP:0010615)1.75687425
81Short thumb (HP:0009778)1.75504870
82Facial hemangioma (HP:0000329)1.74019566
83Abnormally folded helix (HP:0008544)1.72462896
84Atelectasis (HP:0100750)1.70886666
85Amniotic constriction ring (HP:0009775)1.69200845
86Abnormality of placental membranes (HP:0011409)1.69200845
87Breast hypoplasia (HP:0003187)1.67316227
88Absent forearm bone (HP:0003953)1.67180496
89Aplasia involving forearm bones (HP:0009822)1.67180496
90Concave nail (HP:0001598)1.66823475
91Retinal dysplasia (HP:0007973)1.66746736
92Prominent metopic ridge (HP:0005487)1.65796459
93Clubbing of toes (HP:0100760)1.65744946
94Breech presentation (HP:0001623)1.65591299
95Abnormality of cochlea (HP:0000375)1.64675350
96Bowel incontinence (HP:0002607)1.64318595
97Abnormality of midbrain morphology (HP:0002418)1.63982569
98Molar tooth sign on MRI (HP:0002419)1.63982569
99Brittle hair (HP:0002299)1.63963338
100Abnormality of the metopic suture (HP:0005556)1.63812660

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.43228210
2BUB13.10118879
3TRIM283.05292757
4MAP4K22.99016597
5PLK42.89496754
6EIF2AK12.85540616
7VRK22.77623993
8NEK12.73492193
9TTK2.36089310
10CDC72.34779863
11BRSK22.22330587
12SRPK12.06003103
13WEE11.95338816
14NUAK11.93732416
15ZAK1.90949772
16BCKDK1.89765227
17BMPR1B1.87201331
18PLK31.74948503
19TSSK61.73221221
20NME11.71828149
21ATR1.65342736
22PBK1.65065785
23WNK31.63882369
24PLK11.52498722
25NEK21.48963030
26CLK11.48922858
27MUSK1.48226435
28CHEK21.48021756
29BRSK11.42902582
30CCNB11.39987024
31MKNK21.33269652
32WNK41.28545920
33CDK81.25213089
34FLT31.23091092
35FGFR21.19680197
36BCR1.19558727
37PLK21.14812830
38VRK11.12996484
39PDK21.12808309
40FER1.12644029
41ADRBK21.12580306
42EEF2K1.10253027
43MAPK131.02010976
44MKNK11.01581259
45PIM20.99199087
46BRD40.97934812
47ATM0.94367547
48CHEK10.93144950
49CSNK1G10.92976558
50STK390.92665282
51RAF10.88418367
52AKT30.85966938
53SIK30.84386691
54AURKB0.83673114
55TGFBR10.83611393
56MAPKAPK50.83346435
57EIF2AK30.81779972
58STK160.81103982
59CSNK1G30.80748556
60PRKCI0.80531859
61CSNK1A1L0.76122246
62CAMK1D0.75902469
63STK40.71907021
64CDK70.71046912
65LMTK20.67048096
66EIF2AK20.64676165
67TNIK0.62011650
68CDK20.60739960
69CDK10.60015360
70GRK10.59914466
71PRKAA10.59698324
72RPS6KB20.59148105
73STK30.57764644
74SMG10.56446188
75MAP3K100.55732303
76PAK30.54826019
77DAPK10.53368449
78MAPKAPK30.52805249
79MST40.52424964
80ERBB30.52163677
81MET0.51394536
82OXSR10.47285913
83ICK0.45983862
84MAPK110.45056942
85AURKA0.44408899
86NTRK30.43234180
87EPHA20.42321544
88CAMK1G0.41939516
89PKN20.39039708
90MAP3K40.38962413
91IRAK10.38435736
92NLK0.37780866
93CSNK1G20.37568652
94PRKDC0.37360254
95MAP3K20.34491208
96CSNK2A10.34398276
97PAK40.33535406
98CSNK1A10.32978460
99MTOR0.31435071
100GSK3B0.29846647

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.33015550
2Homologous recombination_Homo sapiens_hsa034403.19601817
3Fanconi anemia pathway_Homo sapiens_hsa034603.10183791
4Mismatch repair_Homo sapiens_hsa034302.94239740
5RNA polymerase_Homo sapiens_hsa030202.92873267
6DNA replication_Homo sapiens_hsa030302.76496872
7Non-homologous end-joining_Homo sapiens_hsa034502.70897919
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.64957851
9Base excision repair_Homo sapiens_hsa034102.44305954
10One carbon pool by folate_Homo sapiens_hsa006702.33964427
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.13619954
12Proteasome_Homo sapiens_hsa030502.11526116
13RNA transport_Homo sapiens_hsa030132.03717724
14Steroid biosynthesis_Homo sapiens_hsa001002.03087387
15Selenocompound metabolism_Homo sapiens_hsa004501.97909666
16Nucleotide excision repair_Homo sapiens_hsa034201.83670969
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.74251876
18Cell cycle_Homo sapiens_hsa041101.73185373
19Pyrimidine metabolism_Homo sapiens_hsa002401.72838081
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.72728756
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.64542585
22Basal transcription factors_Homo sapiens_hsa030221.59213030
23Spliceosome_Homo sapiens_hsa030401.58495064
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.58186626
25Propanoate metabolism_Homo sapiens_hsa006401.57567103
26RNA degradation_Homo sapiens_hsa030181.57539979
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51817840
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43473245
29Butanoate metabolism_Homo sapiens_hsa006501.43268157
30Sulfur relay system_Homo sapiens_hsa041221.41284970
31Biosynthesis of amino acids_Homo sapiens_hsa012301.37390877
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.34246575
33Purine metabolism_Homo sapiens_hsa002301.26231880
34Pyruvate metabolism_Homo sapiens_hsa006201.23551216
35Lysine degradation_Homo sapiens_hsa003101.23422385
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23140040
37Protein export_Homo sapiens_hsa030601.21117274
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14930206
39Fatty acid elongation_Homo sapiens_hsa000621.12407532
40Carbon metabolism_Homo sapiens_hsa012001.03415691
41Oocyte meiosis_Homo sapiens_hsa041140.96795753
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96187453
43Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94562692
44mRNA surveillance pathway_Homo sapiens_hsa030150.93314585
45Fructose and mannose metabolism_Homo sapiens_hsa000510.91577749
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.89808899
47Oxidative phosphorylation_Homo sapiens_hsa001900.89426632
48p53 signaling pathway_Homo sapiens_hsa041150.88917897
49Huntingtons disease_Homo sapiens_hsa050160.87393432
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87371480
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86252641
52N-Glycan biosynthesis_Homo sapiens_hsa005100.82543353
53Parkinsons disease_Homo sapiens_hsa050120.80924753
54Nitrogen metabolism_Homo sapiens_hsa009100.80499294
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80214089
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80134373
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78477480
58Peroxisome_Homo sapiens_hsa041460.75216997
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74866650
60Metabolic pathways_Homo sapiens_hsa011000.74715512
61Fatty acid metabolism_Homo sapiens_hsa012120.73695168
62Vitamin B6 metabolism_Homo sapiens_hsa007500.69900794
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69748413
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68763805
65Ether lipid metabolism_Homo sapiens_hsa005650.63068284
66Vitamin digestion and absorption_Homo sapiens_hsa049770.62479348
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.61679839
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60535019
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59827519
70Phototransduction_Homo sapiens_hsa047440.59499326
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57265218
72Hedgehog signaling pathway_Homo sapiens_hsa043400.57072197
73Basal cell carcinoma_Homo sapiens_hsa052170.54064945
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.50855960
75Pentose phosphate pathway_Homo sapiens_hsa000300.47874807
76Glutathione metabolism_Homo sapiens_hsa004800.47824657
77Olfactory transduction_Homo sapiens_hsa047400.45037778
78Nicotine addiction_Homo sapiens_hsa050330.44681243
79Arginine biosynthesis_Homo sapiens_hsa002200.43781374
80Sulfur metabolism_Homo sapiens_hsa009200.40297899
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37293167
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35263544
83Hippo signaling pathway_Homo sapiens_hsa043900.35001153
84Regulation of autophagy_Homo sapiens_hsa041400.34271944
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32674591
86Alzheimers disease_Homo sapiens_hsa050100.29387175
87Caffeine metabolism_Homo sapiens_hsa002320.28878945
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27656619
89Tyrosine metabolism_Homo sapiens_hsa003500.27424302
90Arginine and proline metabolism_Homo sapiens_hsa003300.26855426
91MicroRNAs in cancer_Homo sapiens_hsa052060.24377654
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.22276371
93TGF-beta signaling pathway_Homo sapiens_hsa043500.21883110
94Sphingolipid metabolism_Homo sapiens_hsa006000.21575139
95beta-Alanine metabolism_Homo sapiens_hsa004100.21529559
96mTOR signaling pathway_Homo sapiens_hsa041500.21390628
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18590582
98Thyroid cancer_Homo sapiens_hsa052160.17561680
99ABC transporters_Homo sapiens_hsa020100.17162769
100Wnt signaling pathway_Homo sapiens_hsa043100.16363076

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