C22ORF23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)5.97454220
2cell-substrate junction assembly (GO:0007044)5.24757028
3protein localization to endosome (GO:0036010)4.83248724
4axonemal dynein complex assembly (GO:0070286)4.78964828
5dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.78534934
6cell adhesion mediated by integrin (GO:0033627)4.48943434
7keratinocyte proliferation (GO:0043616)4.35869628
8motile cilium assembly (GO:0044458)4.18260372
9skin morphogenesis (GO:0043589)3.91544656
10planar cell polarity pathway involved in neural tube closure (GO:0090179)3.86902010
11endodermal cell differentiation (GO:0035987)3.78756379
12cilium or flagellum-dependent cell motility (GO:0001539)3.73657275
13epithelial cell differentiation involved in prostate gland development (GO:0060742)3.73560465
14establishment of tissue polarity (GO:0007164)3.68609770
15establishment of planar polarity (GO:0001736)3.68609770
16regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.66491929
17cytoskeletal anchoring at plasma membrane (GO:0007016)3.62368008
18regulation of water loss via skin (GO:0033561)3.56934776
19establishment of skin barrier (GO:0061436)3.56254052
20hypotonic response (GO:0006971)3.47401425
21bundle of His cell to Purkinje myocyte communication (GO:0086069)3.45801408
22surfactant homeostasis (GO:0043129)3.42560895
23semaphorin-plexin signaling pathway (GO:0071526)3.40951361
24negative regulation of chondrocyte differentiation (GO:0032331)3.34157204
25Golgi transport vesicle coating (GO:0048200)3.26131875
26COPI coating of Golgi vesicle (GO:0048205)3.26131875
27negative regulation of keratinocyte proliferation (GO:0010839)3.23397315
28regulation of early endosome to late endosome transport (GO:2000641)3.16661514
29endocytic recycling (GO:0032456)3.10193440
30negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.06481102
31adherens junction assembly (GO:0034333)3.04372511
32cellular copper ion homeostasis (GO:0006878)3.02681790
33epithelial cell-cell adhesion (GO:0090136)2.99743386
34regulation of hair follicle development (GO:0051797)2.98038951
35intermediate filament organization (GO:0045109)2.97498254
36focal adhesion assembly (GO:0048041)2.96011033
37cell-substrate adherens junction assembly (GO:0007045)2.96011033
38cilium movement (GO:0003341)2.94620442
39substrate-dependent cell migration (GO:0006929)2.93792095
40stress fiber assembly (GO:0043149)2.89642847
41maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.88066753
42polarized epithelial cell differentiation (GO:0030859)2.86893830
43negative regulation of anoikis (GO:2000811)2.83047104
44wound healing, spreading of epidermal cells (GO:0035313)2.82521783
45positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.79382610
46barbed-end actin filament capping (GO:0051016)2.73886493
47regulation of NFAT protein import into nucleus (GO:0051532)2.70578905
48mesodermal cell differentiation (GO:0048333)2.69772698
49left/right pattern formation (GO:0060972)2.69617616
50lateral sprouting from an epithelium (GO:0060601)2.68091527
51establishment of apical/basal cell polarity (GO:0035089)2.65175562
52chemical homeostasis within a tissue (GO:0048875)2.65030937
53retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.64349559
54regulation of anoikis (GO:2000209)2.59618932
55extracellular matrix disassembly (GO:0022617)2.59028540
56keratinization (GO:0031424)2.58418608
57apical protein localization (GO:0045176)2.58396332
58basement membrane organization (GO:0071711)2.58100812
59epidermis development (GO:0008544)2.57975755
60endothelial cell chemotaxis (GO:0035767)2.57509158
61wound healing, spreading of cells (GO:0044319)2.56115811
62membrane protein ectodomain proteolysis (GO:0006509)2.54816005
63positive regulation of blood vessel endothelial cell migration (GO:0043536)2.52881010
64atrioventricular valve morphogenesis (GO:0003181)2.52761287
65collagen catabolic process (GO:0030574)2.52054032
66vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.51950363
67positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.51563290
68positive regulation of hair cycle (GO:0042635)2.51391966
69positive regulation of hair follicle development (GO:0051798)2.51391966
70cell junction assembly (GO:0034329)2.50789216
71serine transport (GO:0032329)2.50594870
72regulation of vitamin D biosynthetic process (GO:0060556)2.50256643
73collagen metabolic process (GO:0032963)2.49852107
74multicellular organismal water homeostasis (GO:0050891)2.48313438
75L-serine transport (GO:0015825)2.47703862
76regulation of transforming growth factor beta2 production (GO:0032909)2.47649725
77protein retention in ER lumen (GO:0006621)2.47486348
78regulation of p38MAPK cascade (GO:1900744)2.46833707
79keratinocyte differentiation (GO:0030216)2.46288940
80Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.46072956
81Notch signaling involved in heart development (GO:0061314)2.44542927
82adherens junction organization (GO:0034332)2.44435918
83cell junction organization (GO:0034330)2.43403884
84positive regulation of p38MAPK cascade (GO:1900745)2.42955848
85glomerular epithelial cell development (GO:0072310)2.40872685
86regulation of membrane protein ectodomain proteolysis (GO:0051043)2.39926433
87regulation of establishment of planar polarity (GO:0090175)2.39772430
88membrane tubulation (GO:0097320)2.39236382
89asymmetric protein localization (GO:0008105)2.39068727
90neuron remodeling (GO:0016322)2.36336088
91actin filament bundle assembly (GO:0051017)2.35513209
92actin filament bundle organization (GO:0061572)2.35513209
93activation of MAPKKK activity (GO:0000185)2.34818870
94heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.33543640
95positive regulation of epidermis development (GO:0045684)2.33229338
96neuron projection extension involved in neuron projection guidance (GO:1902284)2.33093246
97axon extension involved in axon guidance (GO:0048846)2.33093246
98positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.32802570
99multicellular organismal macromolecule metabolic process (GO:0044259)2.30831191
100hemidesmosome assembly (GO:0031581)10.0193799

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.97505249
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.35295494
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.05890446
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.91260538
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.89996448
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.83763875
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.51693682
8ELK3_25401928_ChIP-Seq_HUVEC_Human2.18285433
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.13612581
10CLOCK_20551151_ChIP-Seq_293T_Human2.05106939
11P63_26484246_Chip-Seq_KERATINOCYTES_Human2.04488015
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.03721297
13SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.03697115
14SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.03697115
15LXR_22292898_ChIP-Seq_THP-1_Human2.02475932
16SOX9_24532713_ChIP-Seq_HFSC_Mouse2.00267189
17TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.98206426
18KDM2B_26808549_Chip-Seq_SUP-B15_Human1.96593474
19ZNF263_19887448_ChIP-Seq_K562_Human1.90384595
20RACK7_27058665_Chip-Seq_MCF-7_Human1.89314729
21KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.88216984
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.86928537
23KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.85494420
24TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.84254290
25RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.79967596
26UBF1/2_26484160_Chip-Seq_HMECs_Human1.77720262
27P300_27058665_Chip-Seq_ZR-75-30cells_Human1.77466741
28UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.69741394
29KDM2B_26808549_Chip-Seq_K562_Human1.67789922
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67649047
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.59973377
32TP53_22127205_ChIP-Seq_IMR90_Human1.59882924
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.59370385
34ATF3_27146783_Chip-Seq_COLON_Human1.58172817
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54229692
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44869059
37SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.42162422
38ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.37908429
39EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.37201554
40ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37067227
41CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.36066668
42KDM2B_26808549_Chip-Seq_DND41_Human1.35174618
43TP63_22573176_ChIP-Seq_HFKS_Human1.34909412
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.34796591
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.30440708
46TCF7_22412390_ChIP-Seq_EML_Mouse1.29547523
47RUNX1_27514584_Chip-Seq_MCF-7_Human1.28988751
48SMC4_20622854_ChIP-Seq_HELA_Human1.26869548
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.23831572
50NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23698827
51ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23071887
52TBX20_22080862_ChIP-Seq_HEART_Mouse1.22038749
53TBX20_22328084_ChIP-Seq_HEART_Mouse1.22038749
54VDR_21846776_ChIP-Seq_THP-1_Human1.21330259
55EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19576813
56* KLF5_25053715_ChIP-Seq_YYC3_Human1.18472946
57TP53_23651856_ChIP-Seq_MEFs_Mouse1.17625736
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17224794
59PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16421676
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15064377
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13856680
62KDM2B_26808549_Chip-Seq_JURKAT_Human1.13395066
63EGR1_19374776_ChIP-ChIP_THP-1_Human1.11599813
64TP63_23658742_ChIP-Seq_EP156T_Human1.10839571
65TET1_21490601_ChIP-Seq_MESCs_Mouse1.08969291
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08279917
67ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08220731
68JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07812162
69CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07656086
70TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06880195
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.06799595
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06756353
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06653557
74TP53_18474530_ChIP-ChIP_U2OS_Human1.04173677
75NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03618749
76ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03533227
77TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00052951
78SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99682802
79CREB1_26743006_Chip-Seq_LNCaP_Human0.99157159
80HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97663389
81TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97366722
82CTCF_27219007_Chip-Seq_Bcells_Human0.97066441
83CJUN_26792858_Chip-Seq_BT549_Human0.96896725
84JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93683058
85CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92771177
86WT1_19549856_ChIP-ChIP_CCG9911_Human0.92500740
87FOXO3_23340844_ChIP-Seq_DLD1_Human0.90254885
88P68_20966046_ChIP-Seq_HELA_Human0.87559701
89GATA1_19941826_ChIP-Seq_K562_Human0.87460773
90SMC1_22415368_ChIP-Seq_MEFs_Mouse0.86217400
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85425801
92CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84699940
93ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83863015
94SOX2_20726797_ChIP-Seq_SW620_Human0.82918027
95CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82820754
96DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.81917970
97KLF4_18555785_ChIP-Seq_MESCs_Mouse0.81888877
98NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.79865029
99TP53_20018659_ChIP-ChIP_R1E_Mouse0.79232922
100ESR1_21235772_ChIP-Seq_MCF-7_Human0.78626839

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology4.59459678
2MP0003705_abnormal_hypodermis_morpholog4.31928494
3MP0003566_abnormal_cell_adhesion3.36601012
4MP0004272_abnormal_basement_membrane3.23314870
5MP0003453_abnormal_keratinocyte_physiol2.98380845
6MP0005275_abnormal_skin_tensile2.86680393
7MP0008438_abnormal_cutaneous_collagen2.85358746
8MP0010234_abnormal_vibrissa_follicle2.74655175
9MP0001849_ear_inflammation2.72915440
10MP0005409_darkened_coat_color2.66427993
11MP0003941_abnormal_skin_development2.61509320
12MP0005623_abnormal_meninges_morphology2.56335449
13MP0002060_abnormal_skin_morphology2.53619415
14MP0002796_impaired_skin_barrier2.52053030
15MP0000762_abnormal_tongue_morphology2.44567297
16MP0005257_abnormal_intraocular_pressure2.40840213
17MP0002877_abnormal_melanocyte_morpholog2.33530744
18MP0003091_abnormal_cell_migration2.29350049
19MP0000467_abnormal_esophagus_morphology2.16111746
20MP0005023_abnormal_wound_healing2.14111874
21MP0001216_abnormal_epidermal_layer2.01965334
22MP0004858_abnormal_nervous_system1.98419246
23MP0000678_abnormal_parathyroid_gland1.86547764
24MP0005451_abnormal_body_composition1.82320826
25MP0005501_abnormal_skin_physiology1.79877133
26MP0009053_abnormal_anal_canal1.76752075
27MP0010678_abnormal_skin_adnexa1.64399949
28MP0000566_synostosis1.64308215
29MP0003329_amyloid_beta_deposits1.62752090
30MP0002098_abnormal_vibrissa_morphology1.59847412
31MP0001958_emphysema1.57508489
32MP0003300_gastrointestinal_ulcer1.56242446
33MP0005076_abnormal_cell_differentiation1.54824102
34MP0005058_abnormal_lysosome_morphology1.51342749
35MP0008260_abnormal_autophagy1.45959131
36MP0000733_abnormal_muscle_development1.45452166
37MP0000537_abnormal_urethra_morphology1.42706540
38MP0002896_abnormal_bone_mineralization1.42697270
39MP0010771_integument_phenotype1.41301796
40MP0000383_abnormal_hair_follicle1.39376458
41MP0003279_aneurysm1.33969393
42MP0004947_skin_inflammation1.32744834
43MP0000858_altered_metastatic_potential1.26526160
44MP0003303_peritoneal_inflammation1.24838337
45MP0004510_myositis1.24765076
46MP0010368_abnormal_lymphatic_system1.24552855
47MP0000377_abnormal_hair_follicle1.23308467
48MP0004381_abnormal_hair_follicle1.22396294
49MP0001299_abnormal_eye_distance/1.19048741
50MP0010352_gastrointestinal_tract_polyps1.16287022
51MP0009840_abnormal_foam_cell1.15005534
52MP0010030_abnormal_orbit_morphology1.08192541
53MP0003191_abnormal_cellular_cholesterol1.07378818
54MP0003950_abnormal_plasma_membrane1.02570069
55MP0000751_myopathy1.01520592
56MP0000767_abnormal_smooth_muscle1.01435488
57MP0000003_abnormal_adipose_tissue0.99772993
58MP0003828_pulmonary_edema0.99754947
59MP0002234_abnormal_pharynx_morphology0.98893760
60MP0009931_abnormal_skin_appearance0.94774949
61MP0001915_intracranial_hemorrhage0.91994214
62MP0005248_abnormal_Harderian_gland0.89444240
63MP0005164_abnormal_response_to0.87358545
64MP0004264_abnormal_extraembryonic_tissu0.86589523
65MP0003634_abnormal_glial_cell0.86231957
66MP0004782_abnormal_surfactant_physiolog0.85424394
67MP0006054_spinal_hemorrhage0.83532178
68MP0003448_altered_tumor_morphology0.82910442
69MP0001243_abnormal_dermal_layer0.82671138
70MP0005621_abnormal_cell_physiology0.82471754
71MP0005375_adipose_tissue_phenotype0.82021342
72MP0000013_abnormal_adipose_tissue0.80840141
73MP0005508_abnormal_skeleton_morphology0.79729238
74MP0001879_abnormal_lymphatic_vessel0.79136572
75MP0005197_abnormal_uvea_morphology0.79083739
76MP0000604_amyloidosis0.78071298
77MP0003755_abnormal_palate_morphology0.78019515
78MP0000750_abnormal_muscle_regeneration0.77798621
79MP0002282_abnormal_trachea_morphology0.77646788
80MP0002089_abnormal_postnatal_growth/wei0.77576466
81MP0000534_abnormal_ureter_morphology0.76903695
82MP0008789_abnormal_olfactory_epithelium0.76723894
83MP0009780_abnormal_chondrocyte_physiolo0.76403993
84MP0001542_abnormal_bone_strength0.75386196
85MP0004233_abnormal_muscle_weight0.74825224
86MP0002332_abnormal_exercise_endurance0.68742244
87MP0003385_abnormal_body_wall0.68412500
88MP0005193_abnormal_anterior_eye0.67508151
89MP0000747_muscle_weakness0.65597964
90MP0005503_abnormal_tendon_morphology0.64638232
91MP0005394_taste/olfaction_phenotype0.64368307
92MP0005499_abnormal_olfactory_system0.64368307
93MP0003656_abnormal_erythrocyte_physiolo0.64216998
94MP0002998_abnormal_bone_remodeling0.63752262
95MP0003045_fibrosis0.63670590
96MP0000432_abnormal_head_morphology0.63436440
97MP0001340_abnormal_eyelid_morphology0.63050771
98MP0000367_abnormal_coat/_hair0.61386565
99MP0002925_abnormal_cardiovascular_devel0.61043135
100MP0004087_abnormal_muscle_fiber0.60731756

Predicted human phenotypes

RankGene SetZ-score
1Atrophic scars (HP:0001075)5.86454821
2Milia (HP:0001056)5.15000630
3Abnormality of nail color (HP:0100643)4.81138222
4Onycholysis (HP:0001806)4.48545084
5Fragile nails (HP:0001808)4.47872916
6Thick nail (HP:0001805)4.42528775
7Plantar hyperkeratosis (HP:0007556)4.21032535
8Alopecia of scalp (HP:0002293)3.79058021
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.66207086
10Premature rupture of membranes (HP:0001788)3.36509300
11Neurofibrillary tangles (HP:0002185)3.36356750
12Protrusio acetabuli (HP:0003179)3.32850401
13Natal tooth (HP:0000695)3.32837446
14Nail dystrophy (HP:0008404)3.29962291
15Fragile skin (HP:0001030)3.23402806
16Abnormal respiratory motile cilium physiology (HP:0012261)3.05782180
17Palmoplantar hyperkeratosis (HP:0000972)3.04864664
18Dynein arm defect of respiratory motile cilia (HP:0012255)3.01415854
19Absent/shortened dynein arms (HP:0200106)3.01415854
20Abnormal respiratory motile cilium morphology (HP:0005938)2.98673541
21Abnormal respiratory epithelium morphology (HP:0012253)2.98673541
22Abnormal ciliary motility (HP:0012262)2.94387451
23Nasal polyposis (HP:0100582)2.93125159
24Pterygium (HP:0001059)2.86351618
25Palmar hyperkeratosis (HP:0010765)2.86311679
26Cerebral inclusion bodies (HP:0100314)2.82473726
27Abnormality of the nasal mucosa (HP:0000433)2.79757503
28Rhinitis (HP:0012384)2.76088995
29Short nail (HP:0001799)2.74861306
30Popliteal pterygium (HP:0009756)2.62511620
31Right ventricular cardiomyopathy (HP:0011663)2.61663033
32Arterial tortuosity (HP:0005116)2.55826144
33Ankyloglossia (HP:0010296)2.55129194
34Cervical subluxation (HP:0003308)2.52045362
35Abnormal blistering of the skin (HP:0008066)2.51711487
36Ridged nail (HP:0001807)2.49995103
37Vascular tortuosity (HP:0004948)2.46311277
38Neonatal short-limb short stature (HP:0008921)2.40051536
39Advanced eruption of teeth (HP:0006288)2.38226036
40Broad face (HP:0000283)2.37264951
41Upper limb amyotrophy (HP:0009129)2.31224956
42Distal upper limb amyotrophy (HP:0007149)2.31224956
43Ulnar bowing (HP:0003031)2.29500458
44Hypoplasia of dental enamel (HP:0006297)2.29206163
45Selective tooth agenesis (HP:0001592)2.27259501
46Abnormality of dentin (HP:0010299)2.21999748
47Follicular hyperkeratosis (HP:0007502)2.20357572
48Vertebral arch anomaly (HP:0008438)2.17740716
49Abnormality of oral frenula (HP:0000190)2.13905234
50Pili torti (HP:0003777)2.13381163
51Hand muscle atrophy (HP:0009130)2.12929610
52Cerebral aneurysm (HP:0004944)2.06353960
53Lip pit (HP:0100267)2.06131793
54Shallow orbits (HP:0000586)2.03689663
55Flat acetabular roof (HP:0003180)2.01244347
56Male infertility (HP:0003251)1.98213953
57Difficulty climbing stairs (HP:0003551)1.98060365
58Aplasia cutis congenita (HP:0001057)1.95473357
59Thin bony cortex (HP:0002753)1.93654924
60Abnormal hair laboratory examination (HP:0003328)1.91796661
61Spinal rigidity (HP:0003306)1.91742809
62Aortic dissection (HP:0002647)1.88406647
63Sparse scalp hair (HP:0002209)1.88342869
64Bladder diverticulum (HP:0000015)1.88324850
65Abnormality of the distal phalanges of the toes (HP:0010182)1.86163048
66Chronic bronchitis (HP:0004469)1.85904339
67Atelectasis (HP:0100750)1.84985147
68Hyperacusis (HP:0010780)1.82915958
69Distal lower limb muscle weakness (HP:0009053)1.82743135
70Mildly elevated creatine phosphokinase (HP:0008180)1.79372169
71Abnormality of the salivary glands (HP:0010286)1.78823379
72Aortic aneurysm (HP:0004942)1.77657019
73Absent eyelashes (HP:0000561)1.77098033
74Supranuclear gaze palsy (HP:0000605)1.77016031
75Achilles tendon contracture (HP:0001771)1.76878210
76Genu recurvatum (HP:0002816)1.76133981
77Anonychia (HP:0001798)1.74742120
78Obstructive sleep apnea (HP:0002870)1.74484855
79Increased connective tissue (HP:0009025)1.72089099
80Laryngomalacia (HP:0001601)1.70442852
81Corneal erosion (HP:0200020)1.69168438
82Ankle contracture (HP:0006466)1.69115278
83Interstitial pulmonary disease (HP:0006530)1.67958052
84Tibial bowing (HP:0002982)1.67935977
85Hypodontia (HP:0000668)1.67477082
86Wormian bones (HP:0002645)1.66832373
87Abnormality of molar (HP:0011077)1.66161129
88Abnormality of molar morphology (HP:0011070)1.66161129
89Abnormality of the dental root (HP:0006486)1.64887935
90Taurodontia (HP:0000679)1.64887935
91Abnormality of permanent molar morphology (HP:0011071)1.64887935
92Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.64560206
93Hypotrichosis (HP:0001006)1.63585749
94Axonal loss (HP:0003447)1.62946763
95Vertebral compression fractures (HP:0002953)1.61689157
96Absent frontal sinuses (HP:0002688)1.61660505
97Nuclear cataract (HP:0100018)1.61100262
98Mitral regurgitation (HP:0001653)1.59250547
99Asymmetric septal hypertrophy (HP:0001670)1.58787519
100Oligodontia (HP:0000677)1.58028659

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA23.11996191
2TRIB32.81199814
3RIPK12.79922674
4MST1R2.74171233
5IRAK32.66457530
6NTRK12.62863206
7MAPK152.60118435
8LATS22.54045938
9PDGFRA2.51180344
10EPHB22.50390865
11SIK12.32946850
12DDR22.30290325
13CDK122.18014557
14ARAF2.12381365
15MET2.12313848
16PIM22.07768621
17ICK2.00357733
18LATS11.94992148
19TTN1.88089061
20PRPF4B1.87508615
21TESK11.80902692
22SMG11.76983223
23EPHB11.73541320
24MAP3K31.73520648
25PTK21.64306524
26MOS1.62771509
27EEF2K1.62708083
28MAP3K91.55124498
29PAK41.41524933
30LMTK21.37810928
31TAOK11.37675000
32STK381.31863252
33ERN11.27403431
34CDC42BPA1.23661171
35MAP3K21.21941505
36STK241.19316535
37KSR21.14271062
38NEK91.12744450
39NME21.11044299
40TGFBR11.10877993
41MAP3K61.03597165
42RPS6KA21.02882272
43MARK21.02752049
44TGFBR21.00083880
45MTOR0.99923157
46PDGFRB0.97035349
47PRKD20.94327621
48PKN20.87682759
49ROCK20.86017603
50PRKD30.85281461
51MARK10.83721426
52TBK10.82008021
53MAP3K130.80088021
54PAK20.78681379
55TAOK20.76434014
56BMX0.76099012
57TYRO30.70028156
58PTK60.69923636
59BRAF0.68024443
60CDK60.64639374
61MAP3K10.63071389
62CSK0.62591134
63SIK20.61708208
64TRPM70.60389447
65BRD40.57528513
66MAP3K140.55821329
67ERBB40.55464182
68GRK70.55032748
69ROCK10.53501401
70ABL20.51994503
71FGR0.51517557
72RPS6KC10.51074529
73RPS6KL10.51074529
74SGK30.50729672
75CAMK1G0.49747252
76RET0.48461851
77EPHA30.48038949
78MAP2K30.47323057
79PDPK10.47016131
80CAMK1D0.42143414
81MAP3K80.41184566
82FLT30.40409369
83FER0.39853168
84RAF10.39368519
85STK100.38278293
86MAPKAPK30.37912898
87KSR10.37285378
88DYRK1B0.36971197
89PTK2B0.35437563
90CHUK0.34063967
91IRAK10.32781937
92FGFR40.31772339
93DMPK0.31051214
94GSK3A0.31041269
95MAP3K100.29701482
96CDK90.29620584
97MAP3K110.29443723
98SIK30.29051102
99RPS6KA60.28689958
100MAP3K50.28552057

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.64296015
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.38968157
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.35633078
4Focal adhesion_Homo sapiens_hsa045102.02238552
5Bladder cancer_Homo sapiens_hsa052191.93368134
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.85212100
7Amoebiasis_Homo sapiens_hsa051461.84324773
8Small cell lung cancer_Homo sapiens_hsa052221.76353477
9Notch signaling pathway_Homo sapiens_hsa043301.75172251
10Prion diseases_Homo sapiens_hsa050201.74500824
11Adherens junction_Homo sapiens_hsa045201.68833216
12AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.60292499
13Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.59789581
14Chronic myeloid leukemia_Homo sapiens_hsa052201.58633120
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.55610726
16Other glycan degradation_Homo sapiens_hsa005111.53926407
17VEGF signaling pathway_Homo sapiens_hsa043701.53230560
18Proteoglycans in cancer_Homo sapiens_hsa052051.50459169
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.47849324
20Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.32911329
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.31945815
22Neurotrophin signaling pathway_Homo sapiens_hsa047221.29657107
23Pancreatic cancer_Homo sapiens_hsa052121.29252278
24ErbB signaling pathway_Homo sapiens_hsa040121.27814010
25Dilated cardiomyopathy_Homo sapiens_hsa054141.27471970
26Renal cell carcinoma_Homo sapiens_hsa052111.24231474
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.20910989
28Lysosome_Homo sapiens_hsa041421.20701969
29Salmonella infection_Homo sapiens_hsa051321.20065331
30MicroRNAs in cancer_Homo sapiens_hsa052061.15981620
31Acute myeloid leukemia_Homo sapiens_hsa052211.15533763
32Axon guidance_Homo sapiens_hsa043601.14835998
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.13460751
34Endometrial cancer_Homo sapiens_hsa052131.11053037
35Sphingolipid metabolism_Homo sapiens_hsa006001.10575331
36Regulation of actin cytoskeleton_Homo sapiens_hsa048101.10561094
37Toxoplasmosis_Homo sapiens_hsa051451.08656981
38TNF signaling pathway_Homo sapiens_hsa046681.08068428
39Thyroid cancer_Homo sapiens_hsa052161.04544442
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03824380
41Glioma_Homo sapiens_hsa052140.99947233
42Endocytosis_Homo sapiens_hsa041440.99180653
43Leukocyte transendothelial migration_Homo sapiens_hsa046700.96985302
44mTOR signaling pathway_Homo sapiens_hsa041500.95593928
45GnRH signaling pathway_Homo sapiens_hsa049120.95202422
46Insulin signaling pathway_Homo sapiens_hsa049100.94657410
47Hippo signaling pathway_Homo sapiens_hsa043900.92324643
48Shigellosis_Homo sapiens_hsa051310.92172095
49Non-small cell lung cancer_Homo sapiens_hsa052230.90607021
50Pathways in cancer_Homo sapiens_hsa052000.89205503
51Prostate cancer_Homo sapiens_hsa052150.89197346
52Malaria_Homo sapiens_hsa051440.89101476
53Estrogen signaling pathway_Homo sapiens_hsa049150.87948902
54Apoptosis_Homo sapiens_hsa042100.87928689
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87881332
56Dorso-ventral axis formation_Homo sapiens_hsa043200.87825016
57Tight junction_Homo sapiens_hsa045300.87697408
58Hepatitis C_Homo sapiens_hsa051600.86222190
59PI3K-Akt signaling pathway_Homo sapiens_hsa041510.86180861
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.83068531
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82063326
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81172156
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79565557
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78789541
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78738938
66Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78115491
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.78098000
68p53 signaling pathway_Homo sapiens_hsa041150.77781520
69Prolactin signaling pathway_Homo sapiens_hsa049170.77548208
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75476445
71Inositol phosphate metabolism_Homo sapiens_hsa005620.74791177
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.73908782
73Choline metabolism in cancer_Homo sapiens_hsa052310.73676288
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71555746
75Rap1 signaling pathway_Homo sapiens_hsa040150.71474409
76Gap junction_Homo sapiens_hsa045400.70652573
77Fatty acid biosynthesis_Homo sapiens_hsa000610.69454777
78Phenylalanine metabolism_Homo sapiens_hsa003600.69155770
79Protein digestion and absorption_Homo sapiens_hsa049740.69062257
80Insulin resistance_Homo sapiens_hsa049310.68563497
81Fructose and mannose metabolism_Homo sapiens_hsa000510.68388839
82Osteoclast differentiation_Homo sapiens_hsa043800.68003680
83Vibrio cholerae infection_Homo sapiens_hsa051100.67083394
84Melanoma_Homo sapiens_hsa052180.66362841
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65210735
86Hedgehog signaling pathway_Homo sapiens_hsa043400.64438240
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62579247
88Circadian rhythm_Homo sapiens_hsa047100.60928134
89MAPK signaling pathway_Homo sapiens_hsa040100.60878647
90Pertussis_Homo sapiens_hsa051330.60339521
91Melanogenesis_Homo sapiens_hsa049160.60334925
92Hepatitis B_Homo sapiens_hsa051610.60042091
93FoxO signaling pathway_Homo sapiens_hsa040680.59159565
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59123154
95Influenza A_Homo sapiens_hsa051640.59015980
96Phagosome_Homo sapiens_hsa041450.56725618
97Colorectal cancer_Homo sapiens_hsa052100.56310282
98HIF-1 signaling pathway_Homo sapiens_hsa040660.55869941
99AMPK signaling pathway_Homo sapiens_hsa041520.55003029
100Basal cell carcinoma_Homo sapiens_hsa052170.53723356

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