C21ORF62

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)6.96135778
2cilium movement (GO:0003341)6.35149221
3auditory behavior (GO:0031223)5.59530588
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.56460082
5presynaptic membrane assembly (GO:0097105)5.56071792
6postsynaptic membrane organization (GO:0001941)5.32140812
7axonemal dynein complex assembly (GO:0070286)5.14678606
8neuron cell-cell adhesion (GO:0007158)4.89351184
9mechanosensory behavior (GO:0007638)4.87434832
10intraciliary transport (GO:0042073)4.79276945
11cilium or flagellum-dependent cell motility (GO:0001539)4.76844652
12presynaptic membrane organization (GO:0097090)4.63609844
13retinal ganglion cell axon guidance (GO:0031290)4.41852983
14cilium morphogenesis (GO:0060271)4.25712594
15axoneme assembly (GO:0035082)4.18951217
16nonmotile primary cilium assembly (GO:0035058)4.17099147
17response to auditory stimulus (GO:0010996)4.13481932
18pyrimidine nucleobase catabolic process (GO:0006208)4.04208852
19platelet dense granule organization (GO:0060155)3.95557427
20cilium organization (GO:0044782)3.91324708
21cilium assembly (GO:0042384)3.86737132
22C4-dicarboxylate transport (GO:0015740)3.76851868
23regulation of cilium movement (GO:0003352)3.70160286
24positive regulation of mitochondrial fission (GO:0090141)3.56997195
25negative regulation of axon guidance (GO:1902668)3.54127460
26negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.50662093
27vascular smooth muscle contraction (GO:0014829)3.46498115
28vitamin A metabolic process (GO:0006776)3.40191316
29neuron projection extension involved in neuron projection guidance (GO:1902284)3.35792594
30axon extension involved in axon guidance (GO:0048846)3.35792594
31neurotransmitter uptake (GO:0001504)3.33566198
32calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.33129083
33ventricular system development (GO:0021591)3.32422402
34protein polyglutamylation (GO:0018095)3.29224739
35negative regulation of transcription regulatory region DNA binding (GO:2000678)3.27730459
36artery smooth muscle contraction (GO:0014824)3.25196312
37mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.23273164
38positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.23273164
39carnitine metabolic process (GO:0009437)3.19860197
40cell morphogenesis involved in neuron differentiation (GO:0048667)3.14918204
41cullin deneddylation (GO:0010388)3.09761677
42nucleobase catabolic process (GO:0046113)3.09492380
43smoothened signaling pathway (GO:0007224)3.07117722
44vocalization behavior (GO:0071625)3.06839583
45G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.05261757
46negative regulation of axon extension (GO:0030517)3.04512183
47protein localization to cilium (GO:0061512)3.01038953
48cellular component assembly involved in morphogenesis (GO:0010927)3.00898275
49neurotransmitter-gated ion channel clustering (GO:0072578)2.96639439
50behavioral response to nicotine (GO:0035095)2.90903677
51mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.88364236
52sequestering of actin monomers (GO:0042989)2.85525270
53motile cilium assembly (GO:0044458)2.84899424
54positive regulation of gastrulation (GO:2000543)2.82619383
55axonal fasciculation (GO:0007413)2.80122468
56head development (GO:0060322)2.79895786
57cholesterol biosynthetic process (GO:0006695)2.77479042
58regulation of axon guidance (GO:1902667)2.74961568
59cellular response to leptin stimulus (GO:0044320)2.74943744
60regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.73689332
61neuron fate determination (GO:0048664)2.72963481
62startle response (GO:0001964)2.71283994
63positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.71272434
64amino-acid betaine metabolic process (GO:0006577)2.68088902
65regulation of synaptic transmission, glutamatergic (GO:0051966)2.67717313
66tonic smooth muscle contraction (GO:0014820)2.65996366
67appendage development (GO:0048736)2.65582934
68limb development (GO:0060173)2.65582934
69synapse assembly (GO:0007416)2.65184193
70olfactory bulb development (GO:0021772)2.63710877
71ubiquinone metabolic process (GO:0006743)2.63458392
72response to pheromone (GO:0019236)2.60383449
73cysteine metabolic process (GO:0006534)2.60083924
74protein deneddylation (GO:0000338)2.59570429
75short-term memory (GO:0007614)2.59378077
76glycosphingolipid biosynthetic process (GO:0006688)2.57840426
77telencephalon development (GO:0021537)2.56436451
78regulation of feeding behavior (GO:0060259)2.56379022
79nucleoside diphosphate phosphorylation (GO:0006165)2.55452533
80protein localization to synapse (GO:0035418)2.55301400
81regulation of collateral sprouting (GO:0048670)2.53990215
82regulation of cardiac muscle cell contraction (GO:0086004)2.53865278
83sterol biosynthetic process (GO:0016126)2.52576755
84positive regulation of synapse assembly (GO:0051965)2.48625037
85response to nitrosative stress (GO:0051409)2.47855799
86regulation of dopamine secretion (GO:0014059)2.47545408
87neuron recognition (GO:0008038)2.47405651
88regulation of development, heterochronic (GO:0040034)2.47276632
89fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.46841736
90GTP biosynthetic process (GO:0006183)2.46704965
91negative regulation of neurotransmitter transport (GO:0051589)2.45266574
92dendritic spine morphogenesis (GO:0060997)2.44967943
93regulation of timing of cell differentiation (GO:0048505)2.44366872
94negative regulation of membrane potential (GO:0045837)2.42001262
95mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.41839411
96behavioral response to cocaine (GO:0048148)2.41781259
97detection of light stimulus involved in sensory perception (GO:0050962)2.40915053
98detection of light stimulus involved in visual perception (GO:0050908)2.40915053
99microtubule-based movement (GO:0007018)2.40721932
100photoreceptor cell maintenance (GO:0045494)2.40500181

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.56248616
2GBX2_23144817_ChIP-Seq_PC3_Human3.55483979
3IGF1R_20145208_ChIP-Seq_DFB_Human3.25145946
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.23093119
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.91857705
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.90646532
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.82192761
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.76185806
9ZNF274_21170338_ChIP-Seq_K562_Hela2.62678694
10TAF15_26573619_Chip-Seq_HEK293_Human2.61227583
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.59289638
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.56960367
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.36096475
14P300_19829295_ChIP-Seq_ESCs_Human2.28721929
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.28220924
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19502647
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.17888181
18FUS_26573619_Chip-Seq_HEK293_Human2.17217988
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.10782419
20* EWS_26573619_Chip-Seq_HEK293_Human2.08126398
21SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.01405342
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.88602384
23VDR_22108803_ChIP-Seq_LS180_Human1.88025802
24SMAD4_21799915_ChIP-Seq_A2780_Human1.87884601
25OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75968618
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74332911
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.74171273
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.71566241
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.60372964
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59443211
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58381554
32TOP2B_26459242_ChIP-Seq_MCF-7_Human1.56711423
33MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55027837
34TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54881963
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.54881963
36NR3C1_21868756_ChIP-Seq_MCF10A_Human1.54679136
37STAT3_23295773_ChIP-Seq_U87_Human1.51888583
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.49979976
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49818294
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.49725863
41GATA1_26923725_Chip-Seq_HPCs_Mouse1.49395184
42AR_21572438_ChIP-Seq_LNCaP_Human1.49224410
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.49191763
44AR_25329375_ChIP-Seq_VCAP_Human1.48031171
45RNF2_27304074_Chip-Seq_NSC_Mouse1.43747916
46ER_23166858_ChIP-Seq_MCF-7_Human1.42612911
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42437061
48CBP_20019798_ChIP-Seq_JUKART_Human1.41757766
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41757766
50CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39014750
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.38997887
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38614691
53TCF4_22108803_ChIP-Seq_LS180_Human1.36487222
54TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33345608
55REST_21632747_ChIP-Seq_MESCs_Mouse1.32747138
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32521517
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.32244182
58FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.32234539
59* RUNX2_22187159_ChIP-Seq_PCA_Human1.28983666
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27930662
61KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.27728053
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27068344
63TAL1_26923725_Chip-Seq_HPCs_Mouse1.25704893
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.25145981
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24516332
66* TCF4_23295773_ChIP-Seq_U87_Human1.20101889
67EZH2_27304074_Chip-Seq_ESCs_Mouse1.17713667
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17116061
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17075573
70JARID2_20064375_ChIP-Seq_MESCs_Mouse1.17023305
71IRF1_19129219_ChIP-ChIP_H3396_Human1.15416854
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.13943168
73JUN_21703547_ChIP-Seq_K562_Human1.12270265
74REST_18959480_ChIP-ChIP_MESCs_Mouse1.12229051
75BCAT_22108803_ChIP-Seq_LS180_Human1.11931225
76P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10275438
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10023323
78KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.09683396
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08812685
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08790291
81SOX9_26525672_Chip-Seq_HEART_Mouse1.08699989
82ELK1_19687146_ChIP-ChIP_HELA_Human1.08484279
83TP53_18474530_ChIP-ChIP_U2OS_Human1.07739717
84EED_16625203_ChIP-ChIP_MESCs_Mouse1.06490660
85TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05555194
86SOX2_19829295_ChIP-Seq_ESCs_Human1.05232781
87NANOG_19829295_ChIP-Seq_ESCs_Human1.05232781
88SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.04586506
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04178777
90EZH2_27294783_Chip-Seq_NPCs_Mouse1.04090356
91SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02691940
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02637299
93POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02543712
94P53_22387025_ChIP-Seq_ESCs_Mouse1.02308092
95STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02040555
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01911758
97CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01346530
98GABP_17652178_ChIP-ChIP_JURKAT_Human1.01105777
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00397848
100NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00397848

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.74024440
2MP0003011_delayed_dark_adaptation3.36661575
3MP0002653_abnormal_ependyma_morphology3.36213961
4MP0001984_abnormal_olfaction3.32208837
5MP0003880_abnormal_central_pattern3.10797475
6MP0000566_synostosis2.89451818
7MP0001529_abnormal_vocalization2.84441083
8MP0003122_maternal_imprinting2.55029059
9MP0002736_abnormal_nociception_after2.41263124
10MP0005171_absent_coat_pigmentation2.36288728
11MP0006276_abnormal_autonomic_nervous2.30875717
12MP0000778_abnormal_nervous_system2.27568949
13MP0005253_abnormal_eye_physiology1.98264658
14MP0005551_abnormal_eye_electrophysiolog1.95605653
15MP0001968_abnormal_touch/_nociception1.93269530
16MP0004133_heterotaxia1.92124901
17MP0006292_abnormal_olfactory_placode1.87850292
18MP0001486_abnormal_startle_reflex1.86696185
19MP0002638_abnormal_pupillary_reflex1.85405961
20MP0002938_white_spotting1.85055770
21MP0004859_abnormal_synaptic_plasticity1.83747942
22MP0005423_abnormal_somatic_nervous1.80867595
23MP0000569_abnormal_digit_pigmentation1.74123272
24MP0005499_abnormal_olfactory_system1.73673729
25MP0005394_taste/olfaction_phenotype1.73673729
26MP0009745_abnormal_behavioral_response1.72291674
27MP0004142_abnormal_muscle_tone1.65032313
28MP0002734_abnormal_mechanical_nocicepti1.63994458
29MP0008789_abnormal_olfactory_epithelium1.62771165
30MP0002102_abnormal_ear_morphology1.60904309
31MP0005248_abnormal_Harderian_gland1.60727999
32MP0006072_abnormal_retinal_apoptosis1.59575539
33MP0004270_analgesia1.58970799
34MP0002822_catalepsy1.58903323
35MP0002572_abnormal_emotion/affect_behav1.55741839
36MP0000026_abnormal_inner_ear1.50573940
37MP0000372_irregular_coat_pigmentation1.49629220
38MP0003121_genomic_imprinting1.45695697
39MP0003635_abnormal_synaptic_transmissio1.45340943
40MP0003890_abnormal_embryonic-extraembry1.43932801
41MP0002272_abnormal_nervous_system1.41798080
42MP0002064_seizures1.40174429
43MP0001293_anophthalmia1.30983848
44MP0002067_abnormal_sensory_capabilities1.29790253
45MP0002063_abnormal_learning/memory/cond1.28825456
46MP0001324_abnormal_eye_pigmentation1.26730867
47MP0001963_abnormal_hearing_physiology1.26219653
48MP0004885_abnormal_endolymph1.25713818
49MP0002557_abnormal_social/conspecific_i1.23657484
50MP0009697_abnormal_copulation1.23037689
51MP0000955_abnormal_spinal_cord1.22998780
52MP0001970_abnormal_pain_threshold1.22099706
53MP0002751_abnormal_autonomic_nervous1.19129426
54MP0001905_abnormal_dopamine_level1.18775612
55MP0000383_abnormal_hair_follicle1.18348147
56MP0001502_abnormal_circadian_rhythm1.17810219
57MP0001440_abnormal_grooming_behavior1.16198786
58MP0005391_vision/eye_phenotype1.15158637
59MP0001485_abnormal_pinna_reflex1.14760823
60MP0005187_abnormal_penis_morphology1.13785754
61MP0000631_abnormal_neuroendocrine_gland1.13336088
62MP0009046_muscle_twitch1.13145632
63MP0000647_abnormal_sebaceous_gland1.12530946
64MP0002928_abnormal_bile_duct1.11316628
65MP0002752_abnormal_somatic_nervous1.07660937
66MP0002882_abnormal_neuron_morphology1.04897161
67MP0000049_abnormal_middle_ear1.04719453
68MP0002233_abnormal_nose_morphology1.03806985
69MP0000534_abnormal_ureter_morphology1.02591170
70MP0002282_abnormal_trachea_morphology1.01560465
71MP0004019_abnormal_vitamin_homeostasis0.99332225
72MP0010030_abnormal_orbit_morphology0.99306638
73MP0004742_abnormal_vestibular_system0.98874673
74MP0005195_abnormal_posterior_eye0.97842886
75MP0002152_abnormal_brain_morphology0.97804920
76MP0003567_abnormal_fetal_cardiomyocyte0.96011981
77MP0002234_abnormal_pharynx_morphology0.93718094
78MP0002184_abnormal_innervation0.93716099
79MP0005167_abnormal_blood-brain_barrier0.92767873
80MP0003755_abnormal_palate_morphology0.90732141
81MP0003937_abnormal_limbs/digits/tail_de0.90059120
82MP0002733_abnormal_thermal_nociception0.89743541
83MP0002735_abnormal_chemical_nociception0.89237213
84MP0003633_abnormal_nervous_system0.86293324
85MP0001299_abnormal_eye_distance/0.84701217
86MP0002229_neurodegeneration0.81348989
87MP0003137_abnormal_impulse_conducting0.81332089
88MP0000538_abnormal_urinary_bladder0.81323234
89MP0003942_abnormal_urinary_system0.80699815
90MP0008877_abnormal_DNA_methylation0.79561647
91MP0000516_abnormal_urinary_system0.79041664
92MP0005367_renal/urinary_system_phenotyp0.79041664
93MP0002095_abnormal_skin_pigmentation0.78986682
94MP0003861_abnormal_nervous_system0.78793531
95MP0004924_abnormal_behavior0.76707674
96MP0005386_behavior/neurological_phenoty0.76707674
97MP0003631_nervous_system_phenotype0.75959123
98MP0000427_abnormal_hair_cycle0.75188532
99MP0002090_abnormal_vision0.74163532
100MP0008569_lethality_at_weaning0.73676622

Predicted human phenotypes

RankGene SetZ-score
1True hermaphroditism (HP:0010459)5.00410368
2Abnormal ciliary motility (HP:0012262)4.46650589
3Medial flaring of the eyebrow (HP:0010747)4.40558708
4Abnormal respiratory motile cilium physiology (HP:0012261)4.39089392
5Occipital encephalocele (HP:0002085)4.33111417
6Pancreatic fibrosis (HP:0100732)4.31042414
7Pancreatic cysts (HP:0001737)4.18971838
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.14500817
9Molar tooth sign on MRI (HP:0002419)4.08022693
10Abnormality of midbrain morphology (HP:0002418)4.08022693
11Hemiparesis (HP:0001269)4.00968250
12Gait imbalance (HP:0002141)3.92746923
13Congenital primary aphakia (HP:0007707)3.82530196
14Nephronophthisis (HP:0000090)3.82213306
15Abnormal respiratory motile cilium morphology (HP:0005938)3.80530682
16Abnormal respiratory epithelium morphology (HP:0012253)3.80530682
17Nephrogenic diabetes insipidus (HP:0009806)3.58683329
18Rhinitis (HP:0012384)3.57362736
19Aplasia/Hypoplasia of the tibia (HP:0005772)3.16102206
20Cystic liver disease (HP:0006706)3.15685277
21Genital tract atresia (HP:0001827)3.14136382
22Vaginal atresia (HP:0000148)3.13961734
23Short tibia (HP:0005736)3.04557224
24Focal motor seizures (HP:0011153)3.04130732
25Aplasia/Hypoplasia of the tongue (HP:0010295)3.03017877
26Polyphagia (HP:0002591)3.01055613
27Abnormality of the renal medulla (HP:0100957)2.97473476
28Chronic hepatic failure (HP:0100626)2.89868214
29Postaxial foot polydactyly (HP:0001830)2.87757152
30Postaxial hand polydactyly (HP:0001162)2.84980751
31Sclerocornea (HP:0000647)2.78751500
32Absent/shortened dynein arms (HP:0200106)2.71949966
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.71949966
34Hyperglycinemia (HP:0002154)2.62024385
35Poor coordination (HP:0002370)2.61695115
36Myokymia (HP:0002411)2.61396821
37Congenital hepatic fibrosis (HP:0002612)2.58433231
38Supernumerary spleens (HP:0009799)2.57803370
39Hemiplegia (HP:0002301)2.54921243
40Septo-optic dysplasia (HP:0100842)2.52786914
41Anencephaly (HP:0002323)2.51128388
42Abnormality of the labia minora (HP:0012880)2.50286036
43Bile duct proliferation (HP:0001408)2.47162074
44Abnormal biliary tract physiology (HP:0012439)2.47162074
45Narrow forehead (HP:0000341)2.44551148
46Tubulointerstitial nephritis (HP:0001970)2.42918615
47Oculomotor apraxia (HP:0000657)2.40375410
48Broad foot (HP:0001769)2.39033568
49Tubular atrophy (HP:0000092)2.38055758
50Preaxial hand polydactyly (HP:0001177)2.37387802
51Male pseudohermaphroditism (HP:0000037)2.30205015
52Action tremor (HP:0002345)2.29705255
53Increased corneal curvature (HP:0100692)2.26737423
54Keratoconus (HP:0000563)2.26737423
55Mitochondrial inheritance (HP:0001427)2.20639171
56Decreased central vision (HP:0007663)2.19279064
57Hypomagnesemia (HP:0002917)2.19014148
58Acute necrotizing encephalopathy (HP:0006965)2.18221253
59Specific learning disability (HP:0001328)2.16342165
60Aplasia/Hypoplasia of the lens (HP:0008063)2.14975272
61Type 2 muscle fiber atrophy (HP:0003554)2.12214940
62Hyperventilation (HP:0002883)2.09185090
63Retinal dysplasia (HP:0007973)2.08102914
64Optic nerve hypoplasia (HP:0000609)2.04198439
65Sensorimotor neuropathy (HP:0007141)2.03795825
66Lipid accumulation in hepatocytes (HP:0006561)2.03099607
67Bifid tongue (HP:0010297)2.02348176
68Abnormality of glycine metabolism (HP:0010895)2.00158002
69Abnormality of serine family amino acid metabolism (HP:0010894)2.00158002
70Colon cancer (HP:0003003)1.99786825
71Increased hepatocellular lipid droplets (HP:0006565)1.99371453
72Epidermoid cyst (HP:0200040)1.98971155
73Progressive macrocephaly (HP:0004481)1.98953336
74Tubulointerstitial abnormality (HP:0001969)1.98234831
75Acute encephalopathy (HP:0006846)1.97641625
76Abnormal mitochondria in muscle tissue (HP:0008316)1.92203439
77Furrowed tongue (HP:0000221)1.90971557
78Polyuria (HP:0000103)1.88095111
79Bronchiectasis (HP:0002110)1.87663308
80Prominent nasal bridge (HP:0000426)1.87567168
81Left ventricular hypertrophy (HP:0001712)1.87398206
82Progressive cerebellar ataxia (HP:0002073)1.87123490
83Hyperglycinuria (HP:0003108)1.86973409
84Abnormality of the renal cortex (HP:0011035)1.82646309
85Anophthalmia (HP:0000528)1.82315234
86Median cleft lip (HP:0000161)1.81815145
87Aganglionic megacolon (HP:0002251)1.80732999
88Absent septum pellucidum (HP:0001331)1.78662719
89Chronic bronchitis (HP:0004469)1.78581375
90Decreased testicular size (HP:0008734)1.78169240
91Exercise-induced muscle cramps (HP:0003710)1.78085572
92Split foot (HP:0001839)1.75874369
93Cerebellar dysplasia (HP:0007033)1.75843972
94Increased CSF lactate (HP:0002490)1.74967964
95Drooling (HP:0002307)1.72778931
96Abnormal eating behavior (HP:0100738)1.72584745
97Decreased electroretinogram (ERG) amplitude (HP:0000654)1.70931929
98Large for gestational age (HP:0001520)1.70039257
99Polydipsia (HP:0001959)1.68884569
100Abnormal drinking behavior (HP:0030082)1.68884569

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.90286950
2MARK13.67148512
3TNIK2.91187275
4MAP3K42.68233563
5WNK32.67772455
6BCKDK2.28043459
7MAP2K72.25103597
8BMPR1B2.23801567
9MAPK132.12456447
10MST42.12258491
11NTRK22.07588231
12MAP4K22.05446059
13BCR1.99410340
14CSNK1G21.98349971
15PLK21.95253800
16CCNB11.86888664
17PINK11.84532410
18FRK1.81858457
19CSNK1G31.78068594
20PBK1.64474022
21ERBB31.64460707
22MAPK151.64065237
23CSNK1G11.59885661
24ADRBK21.57118504
25DYRK21.56307215
26CSNK1A1L1.52516995
27DYRK31.47446112
28TRIM281.46736056
29FGFR21.45069915
30PTK2B1.35759071
31EPHA41.29049172
32NEK91.23595385
33EPHA31.23151156
34PNCK1.21259977
35EPHB11.15190158
36STK391.08231477
37PDK20.99387632
38SRPK10.96060804
39PRKCE0.96056818
40ERBB40.96049342
41MKNK20.95665704
42STK38L0.94167681
43MUSK0.93829248
44DYRK1A0.92950665
45MKNK10.88615416
46TAOK10.86055209
47WNK40.85466393
48GRK10.83109880
49RPS6KA40.82833984
50WEE10.81727306
51PAK60.80465828
52NTRK30.77395453
53PRKCG0.75852096
54EPHB20.75054222
55PAK30.74804451
56LMTK20.73403979
57CAMK2A0.72461871
58MAP2K40.71759116
59STK160.70078164
60PHKG10.68207895
61PHKG20.68207895
62ROCK20.67733761
63BRD40.66951227
64CDK190.64301239
65UHMK10.62610846
66MINK10.58847888
67SGK4940.55151099
68SGK2230.55151099
69CSNK1A10.55123832
70PRKACA0.53288822
71VRK10.53185566
72PRKD30.52936678
73PRKG10.50743693
74MET0.50658313
75CDK50.49741808
76ERBB20.49559097
77NEK10.48593200
78FER0.46771920
79TGFBR10.46298452
80CAMK2B0.46021257
81ACVR1B0.45494282
82LIMK10.45477578
83SGK20.42928141
84CAMKK20.42820246
85RPS6KA50.42150105
86INSRR0.41954792
87CDK30.41931096
88OXSR10.40883773
89PASK0.40211475
90CAMK2D0.39355355
91CDK140.39244736
92NEK60.38524727
93PKN10.38469695
94PLK30.35784015
95TAOK30.35153939
96PRKACB0.34032662
97DYRK1B0.31729422
98OBSCN0.30536688
99CDK180.30307645
100PRKACG0.27789872

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.00789460
2Steroid biosynthesis_Homo sapiens_hsa001003.08635489
3Protein export_Homo sapiens_hsa030602.94231418
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.74998325
5Oxidative phosphorylation_Homo sapiens_hsa001902.53736205
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.45983813
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.45422744
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.44052087
9Propanoate metabolism_Homo sapiens_hsa006402.43225668
10Parkinsons disease_Homo sapiens_hsa050122.35946025
11Butanoate metabolism_Homo sapiens_hsa006502.28957500
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.27012259
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.23445562
14Nitrogen metabolism_Homo sapiens_hsa009102.20737005
15Nicotine addiction_Homo sapiens_hsa050332.18176173
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.96327108
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.90175220
18Huntingtons disease_Homo sapiens_hsa050161.84407647
19Fatty acid elongation_Homo sapiens_hsa000621.82097084
20Peroxisome_Homo sapiens_hsa041461.63027730
21Fatty acid metabolism_Homo sapiens_hsa012121.61608488
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59634680
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54655193
24Alzheimers disease_Homo sapiens_hsa050101.51323260
25Phototransduction_Homo sapiens_hsa047441.51195823
26Cocaine addiction_Homo sapiens_hsa050301.37575021
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.29915979
28Basal cell carcinoma_Homo sapiens_hsa052171.27254657
29GABAergic synapse_Homo sapiens_hsa047271.26843126
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.20346383
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20263681
32Collecting duct acid secretion_Homo sapiens_hsa049661.15977731
33Fatty acid degradation_Homo sapiens_hsa000711.15124289
34beta-Alanine metabolism_Homo sapiens_hsa004101.09410235
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.07030167
36Glutamatergic synapse_Homo sapiens_hsa047241.06562279
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04432988
38Tryptophan metabolism_Homo sapiens_hsa003801.03498275
39Cardiac muscle contraction_Homo sapiens_hsa042601.02931065
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02462339
41Hedgehog signaling pathway_Homo sapiens_hsa043401.00975376
42Dopaminergic synapse_Homo sapiens_hsa047281.00319075
43Pyruvate metabolism_Homo sapiens_hsa006200.97594766
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97522786
45Axon guidance_Homo sapiens_hsa043600.97014440
46Morphine addiction_Homo sapiens_hsa050320.93189639
47Circadian entrainment_Homo sapiens_hsa047130.92547851
48Taste transduction_Homo sapiens_hsa047420.91334569
49Vitamin B6 metabolism_Homo sapiens_hsa007500.89642516
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88919843
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87463848
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85766785
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85521524
54RNA polymerase_Homo sapiens_hsa030200.79037075
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.79016088
56Linoleic acid metabolism_Homo sapiens_hsa005910.74806007
57Carbon metabolism_Homo sapiens_hsa012000.73768933
58Serotonergic synapse_Homo sapiens_hsa047260.73591624
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73081951
60Olfactory transduction_Homo sapiens_hsa047400.72304487
61Metabolic pathways_Homo sapiens_hsa011000.70253954
62Chemical carcinogenesis_Homo sapiens_hsa052040.67451533
63Amphetamine addiction_Homo sapiens_hsa050310.64680982
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63800059
65Basal transcription factors_Homo sapiens_hsa030220.63792255
66Arginine and proline metabolism_Homo sapiens_hsa003300.63447667
67Ether lipid metabolism_Homo sapiens_hsa005650.63431639
68Hippo signaling pathway_Homo sapiens_hsa043900.63327535
69PPAR signaling pathway_Homo sapiens_hsa033200.61789543
70RNA degradation_Homo sapiens_hsa030180.61703337
71Retinol metabolism_Homo sapiens_hsa008300.61682524
72Regulation of autophagy_Homo sapiens_hsa041400.60893047
73Folate biosynthesis_Homo sapiens_hsa007900.60809442
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.58312280
75Insulin secretion_Homo sapiens_hsa049110.56672066
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.55744094
77Fanconi anemia pathway_Homo sapiens_hsa034600.54838519
78Histidine metabolism_Homo sapiens_hsa003400.54443284
79Glutathione metabolism_Homo sapiens_hsa004800.51499504
80Biosynthesis of amino acids_Homo sapiens_hsa012300.48233378
81Caffeine metabolism_Homo sapiens_hsa002320.45725516
82Gap junction_Homo sapiens_hsa045400.44263684
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40452085
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39453529
85Alcoholism_Homo sapiens_hsa050340.38606668
86Circadian rhythm_Homo sapiens_hsa047100.37444014
87Fructose and mannose metabolism_Homo sapiens_hsa000510.36267905
88Fat digestion and absorption_Homo sapiens_hsa049750.33783358
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.33353519
90Melanogenesis_Homo sapiens_hsa049160.33046438
91Gastric acid secretion_Homo sapiens_hsa049710.30839566
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30748443
93cAMP signaling pathway_Homo sapiens_hsa040240.30362123
94Fatty acid biosynthesis_Homo sapiens_hsa000610.29665604
95Glycerolipid metabolism_Homo sapiens_hsa005610.29118089
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27051898
97Purine metabolism_Homo sapiens_hsa002300.25633995
98ABC transporters_Homo sapiens_hsa020100.25463688
99Synaptic vesicle cycle_Homo sapiens_hsa047210.24753457
100Lysine degradation_Homo sapiens_hsa003100.23599685

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