C20ORF96

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)8.52457809
2axoneme assembly (GO:0035082)7.34866866
3regulation of cilium movement (GO:0003352)6.58490911
4left/right pattern formation (GO:0060972)6.10266636
5intraciliary transport (GO:0042073)6.08736077
6microtubule bundle formation (GO:0001578)5.09720023
7centriole assembly (GO:0098534)5.02471995
8cilium organization (GO:0044782)5.01056190
9left/right axis specification (GO:0070986)4.90872832
10cilium assembly (GO:0042384)4.87679977
11centriole replication (GO:0007099)4.82170878
12ventricular system development (GO:0021591)4.70591321
13primary alcohol catabolic process (GO:0034310)4.26301234
14vitamin transmembrane transport (GO:0035461)4.05080130
15cilium morphogenesis (GO:0060271)4.03122834
16regulation of microtubule-based movement (GO:0060632)4.00934416
17microtubule-based movement (GO:0007018)3.91087166
18lung epithelium development (GO:0060428)3.81488353
19intra-S DNA damage checkpoint (GO:0031573)3.79224909
20cellular component assembly involved in morphogenesis (GO:0010927)3.77535637
21nonmotile primary cilium assembly (GO:0035058)3.64452748
22microtubule depolymerization (GO:0007019)3.59196427
23retinal rod cell development (GO:0046548)3.58486400
24protein localization to cilium (GO:0061512)3.57816172
25establishment or maintenance of monopolar cell polarity (GO:0061339)3.43521997
26establishment of monopolar cell polarity (GO:0061162)3.43521997
27response to misfolded protein (GO:0051788)3.32430057
28cell projection assembly (GO:0030031)3.32019141
29photoreceptor cell maintenance (GO:0045494)3.26323380
30ethanol metabolic process (GO:0006067)3.24123474
31histone H2A acetylation (GO:0043968)3.19477104
32microtubule polymerization or depolymerization (GO:0031109)3.13227560
33aldehyde catabolic process (GO:0046185)3.11885067
34nucleoside diphosphate phosphorylation (GO:0006165)3.10105252
35regulation of collateral sprouting (GO:0048670)3.06927833
36negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.05334350
37lateral ventricle development (GO:0021670)3.03162453
38microtubule severing (GO:0051013)3.02901855
39protein polyglutamylation (GO:0018095)2.95546283
40regulation of microtubule depolymerization (GO:0031114)2.91873671
41DNA integration (GO:0015074)2.88067899
42negative regulation of DNA-templated transcription, elongation (GO:0032785)2.79023949
43sperm motility (GO:0030317)2.77180916
44establishment of apical/basal cell polarity (GO:0035089)2.75522370
45negative regulation of T cell differentiation in thymus (GO:0033085)2.72354781
46microtubule-based process (GO:0007017)2.67066121
47positive regulation of smoothened signaling pathway (GO:0045880)2.64129733
48negative regulation of microtubule depolymerization (GO:0007026)2.59878367
49terpenoid biosynthetic process (GO:0016114)2.59508328
50organelle assembly (GO:0070925)2.59491956
51sperm capacitation (GO:0048240)2.59135767
52smoothened signaling pathway (GO:0007224)2.56847042
53pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.55008311
54mismatch repair (GO:0006298)2.51508728
55GTP biosynthetic process (GO:0006183)2.49881651
56regulation of helicase activity (GO:0051095)2.47356105
57cytoplasmic microtubule organization (GO:0031122)2.44108328
58neurotransmitter catabolic process (GO:0042135)2.41307386
59ubiquinone biosynthetic process (GO:0006744)2.41221545
60hydrogen peroxide catabolic process (GO:0042744)2.41018737
61determination of left/right symmetry (GO:0007368)2.40361052
62diterpenoid biosynthetic process (GO:0016102)2.39850704
63glutathione derivative biosynthetic process (GO:1901687)2.38376591
64glutathione derivative metabolic process (GO:1901685)2.38376591
65ubiquinone metabolic process (GO:0006743)2.37635682
66one-carbon compound transport (GO:0019755)2.35916246
67retinal cone cell development (GO:0046549)2.34645284
68determination of bilateral symmetry (GO:0009855)2.34063469
69DNA double-strand break processing (GO:0000729)2.33940569
70pyrimidine-containing compound transmembrane transport (GO:0072531)2.33445117
71specification of symmetry (GO:0009799)2.30699769
72pyrimidine nucleotide catabolic process (GO:0006244)2.29759570
73seminiferous tubule development (GO:0072520)2.26762116
74UTP metabolic process (GO:0046051)2.23939310
75nucleotide phosphorylation (GO:0046939)2.23008801
76spermatid development (GO:0007286)2.22162778
77mRNA splice site selection (GO:0006376)2.21072080
78oxidative phosphorylation (GO:0006119)2.21062108
79ethanol oxidation (GO:0006069)2.20909540
80multicellular organismal aging (GO:0010259)2.19104046
81positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.18837843
82mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.18837843
83protein insertion into membrane (GO:0051205)2.18283272
84pyrimidine nucleobase catabolic process (GO:0006208)2.16769251
85UTP biosynthetic process (GO:0006228)2.16729705
86response to xenobiotic stimulus (GO:0009410)2.16712548
87regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.15413898
88retinoic acid metabolic process (GO:0042573)2.15182737
89positive regulation of cell size (GO:0045793)2.15036693
90establishment of mitochondrion localization (GO:0051654)2.11356845
91GPI anchor biosynthetic process (GO:0006506)2.11205678
92establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.10805536
93mitochondrion transport along microtubule (GO:0047497)2.10805536
94limb development (GO:0060173)2.10166230
95appendage development (GO:0048736)2.10166230
96axonemal dynein complex assembly (GO:0070286)13.5370335
97cilium or flagellum-dependent cell motility (GO:0001539)11.2051174
98cilium movement (GO:0003341)10.8283776
99epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.3333697
100epithelial cilium movement (GO:0003351)10.2058880

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.99854824
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.38567402
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.36729757
4ZNF274_21170338_ChIP-Seq_K562_Hela3.31110600
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.17083207
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.44279731
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40621997
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.36529035
9EZH2_22144423_ChIP-Seq_EOC_Human2.31641527
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.22275483
11CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.18800048
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.18698314
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.07760786
14VDR_22108803_ChIP-Seq_LS180_Human2.05406043
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.04560826
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.00530581
17DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.97952332
18GABP_17652178_ChIP-ChIP_JURKAT_Human1.94083807
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88916971
20ESR1_15608294_ChIP-ChIP_MCF-7_Human1.84514732
21GABP_19822575_ChIP-Seq_HepG2_Human1.82321786
22IGF1R_20145208_ChIP-Seq_DFB_Human1.81232760
23ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.80896056
24SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.77988609
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.70761835
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.63700097
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63247881
28CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.60071482
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.58829018
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.52873793
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.52115847
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.51857752
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49017838
34SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.47253622
35EWS_26573619_Chip-Seq_HEK293_Human1.47095623
36IRF1_19129219_ChIP-ChIP_H3396_Human1.44730305
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.44626185
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44395712
39XRN2_22483619_ChIP-Seq_HELA_Human1.41711401
40MYC_18940864_ChIP-ChIP_HL60_Human1.41683224
41* YY1_22570637_ChIP-Seq_MALME-3M_Human1.41423081
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39630658
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.36540418
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30630880
45MYC_18555785_ChIP-Seq_MESCs_Mouse1.30057141
46DCP1A_22483619_ChIP-Seq_HELA_Human1.28494306
47SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26887469
48DROSHA_22980978_ChIP-Seq_HELA_Human1.26483518
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.22107226
50TTF2_22483619_ChIP-Seq_HELA_Human1.21198486
51* FOXP3_21729870_ChIP-Seq_TREG_Human1.20330418
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19454266
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.19126397
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19092009
55CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.18416764
56FOXP1_21924763_ChIP-Seq_HESCs_Human1.17575592
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.17126643
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15431227
59STAT1_20625510_ChIP-Seq_HELA_Human1.15304662
60CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.14570012
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.12992615
62AR_21909140_ChIP-Seq_LNCAP_Human1.11004290
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10531079
64VDR_23849224_ChIP-Seq_CD4+_Human1.09617425
65E2F1_17053090_ChIP-ChIP_MCF-7_Human1.08256175
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08180602
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.06557513
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05818859
69PHF8_20622854_ChIP-Seq_HELA_Human1.04824723
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.04394152
71RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03416268
72E2F4_17652178_ChIP-ChIP_JURKAT_Human1.02199950
73FUS_26573619_Chip-Seq_HEK293_Human1.02046329
74RNF2_27304074_Chip-Seq_NSC_Mouse0.98916368
75ERA_21632823_ChIP-Seq_H3396_Human0.98606495
76NCOR_22424771_ChIP-Seq_293T_Human0.96028719
77GATA1_26923725_Chip-Seq_HPCs_Mouse0.93973971
78SALL1_21062744_ChIP-ChIP_HESCs_Human0.93803951
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92529987
80RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92338830
81NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91355052
82WDR5_24793694_ChIP-Seq_LNCAP_Human0.90571976
83AR_20517297_ChIP-Seq_VCAP_Human0.88844482
84P68_20966046_ChIP-Seq_HELA_Human0.87645475
85TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.86271480
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85948143
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85948143
88EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.85681347
89ELK1_19687146_ChIP-ChIP_HELA_Human0.83479124
90KDM5A_27292631_Chip-Seq_BREAST_Human0.80609490
91* SOX2_16153702_ChIP-ChIP_HESCs_Human0.79712927
92CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.77961692
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.77701681
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.76977401
95SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.76848177
96SOX3_22085726_ChIP-Seq_NPCs_Mouse0.76321260
97RAD21_21589869_ChIP-Seq_MESCs_Mouse0.76235380
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.76110395
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74691413
100CTBP2_25329375_ChIP-Seq_LNCAP_Human0.71953580

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology5.57422441
2MP0008789_abnormal_olfactory_epithelium3.59773902
3MP0000566_synostosis3.28766257
4MP0005499_abnormal_olfactory_system3.22603061
5MP0005394_taste/olfaction_phenotype3.22603061
6MP0004133_heterotaxia2.90403957
7MP0002132_abnormal_respiratory_system2.84982151
8MP0008877_abnormal_DNA_methylation2.82238567
9MP0006292_abnormal_olfactory_placode2.79212520
10MP0001984_abnormal_olfaction2.78694177
11MP0008875_abnormal_xenobiotic_pharmacok2.51167999
12MP0001293_anophthalmia2.18129490
13MP0006276_abnormal_autonomic_nervous2.09704982
14MP0003718_maternal_effect2.04941080
15MP0002822_catalepsy1.99699401
16MP0004043_abnormal_pH_regulation1.93610823
17MP0006072_abnormal_retinal_apoptosis1.84718864
18MP0001529_abnormal_vocalization1.77014658
19MP0010030_abnormal_orbit_morphology1.76080272
20MP0002282_abnormal_trachea_morphology1.74657100
21MP0003890_abnormal_embryonic-extraembry1.73835860
22MP0002233_abnormal_nose_morphology1.62095592
23MP0008058_abnormal_DNA_repair1.59972806
24MP0003122_maternal_imprinting1.55959438
25MP0001299_abnormal_eye_distance/1.55604385
26MP0002751_abnormal_autonomic_nervous1.45602500
27MP0000049_abnormal_middle_ear1.42299304
28MP0005253_abnormal_eye_physiology1.38800907
29MP0003121_genomic_imprinting1.35288104
30MP0003119_abnormal_digestive_system1.33750081
31MP0008995_early_reproductive_senescence1.31423846
32MP0005083_abnormal_biliary_tract1.30929970
33MP0003136_yellow_coat_color1.30317849
34MP0001348_abnormal_lacrimal_gland1.30125186
35MP0002277_abnormal_respiratory_mucosa1.27555612
36MP0002102_abnormal_ear_morphology1.27130493
37MP0001929_abnormal_gametogenesis1.26748968
38MP0003283_abnormal_digestive_organ1.25933917
39MP0002092_abnormal_eye_morphology1.24844291
40MP0003938_abnormal_ear_development1.21302870
41MP0005391_vision/eye_phenotype1.18729394
42MP0003693_abnormal_embryo_hatching1.18317870
43MP0000026_abnormal_inner_ear1.17203114
44MP0000778_abnormal_nervous_system1.14708700
45MP0003698_abnormal_male_reproductive1.10406827
46MP0003787_abnormal_imprinting1.08603697
47MP0002557_abnormal_social/conspecific_i1.08357918
48MP0002249_abnormal_larynx_morphology1.05977177
49MP0002938_white_spotting1.05761529
50MP0000631_abnormal_neuroendocrine_gland1.05005734
51MP0003861_abnormal_nervous_system1.04120450
52MP0006036_abnormal_mitochondrial_physio1.03650762
53MP0005551_abnormal_eye_electrophysiolog1.03271310
54MP0001145_abnormal_male_reproductive1.02870032
55MP0001486_abnormal_startle_reflex1.01873382
56MP0002735_abnormal_chemical_nociception1.01386462
57MP0002160_abnormal_reproductive_system0.99767931
58MP0000653_abnormal_sex_gland0.99220586
59MP0003878_abnormal_ear_physiology0.99051897
60MP0005377_hearing/vestibular/ear_phenot0.99051897
61MP0002210_abnormal_sex_determination0.98872079
62MP0002234_abnormal_pharynx_morphology0.98311959
63MP0002752_abnormal_somatic_nervous0.97380208
64MP0003937_abnormal_limbs/digits/tail_de0.96695537
65MP0001485_abnormal_pinna_reflex0.96297220
66MP0001286_abnormal_eye_development0.95680918
67MP0005220_abnormal_exocrine_pancreas0.92987832
68MP0008057_abnormal_DNA_replication0.92916333
69MP0010094_abnormal_chromosome_stability0.90663328
70MP0004742_abnormal_vestibular_system0.89251215
71MP0003567_abnormal_fetal_cardiomyocyte0.88495092
72MP0001545_abnormal_hematopoietic_system0.87687816
73MP0005397_hematopoietic_system_phenotyp0.87687816
74MP0000383_abnormal_hair_follicle0.86627140
75MP0008932_abnormal_embryonic_tissue0.85535160
76MP0002734_abnormal_mechanical_nocicepti0.84465135
77MP0003186_abnormal_redox_activity0.84260022
78MP0005195_abnormal_posterior_eye0.83411364
79MP0003111_abnormal_nucleus_morphology0.83156550
80MP0004147_increased_porphyrin_level0.82595944
81MP0009703_decreased_birth_body0.82084846
82MP0000955_abnormal_spinal_cord0.81979547
83MP0002638_abnormal_pupillary_reflex0.81865046
84MP0009780_abnormal_chondrocyte_physiolo0.81627029
85MP0006035_abnormal_mitochondrial_morpho0.81322741
86MP0005395_other_phenotype0.80787010
87MP0002111_abnormal_tail_morphology0.79011492
88MP0002084_abnormal_developmental_patter0.78699855
89MP0003942_abnormal_urinary_system0.78459956
90MP0002116_abnormal_craniofacial_bone0.78118741
91MP0002152_abnormal_brain_morphology0.77447435
92MP0002161_abnormal_fertility/fecundity0.74469626
93MP0001963_abnormal_hearing_physiology0.73933271
94MP0000358_abnormal_cell_content/0.73299470
95MP0002085_abnormal_embryonic_tissue0.73106746
96MP0002882_abnormal_neuron_morphology0.72360664
97MP0003077_abnormal_cell_cycle0.71084156
98MP0002572_abnormal_emotion/affect_behav0.69909918
99MP0009046_muscle_twitch0.68446949
100MP0005623_abnormal_meninges_morphology0.68015994

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.00214501
2Abnormal respiratory epithelium morphology (HP:0012253)9.00214501
3Abnormal respiratory motile cilium physiology (HP:0012261)8.83230357
4Dynein arm defect of respiratory motile cilia (HP:0012255)8.60651785
5Absent/shortened dynein arms (HP:0200106)8.60651785
6Abnormal ciliary motility (HP:0012262)8.58212210
7Rhinitis (HP:0012384)7.98260820
8Chronic bronchitis (HP:0004469)6.34379039
9Bronchiectasis (HP:0002110)5.37791330
10Pancreatic fibrosis (HP:0100732)4.61697484
11Nasal polyposis (HP:0100582)4.26341518
12True hermaphroditism (HP:0010459)4.17291573
13Occipital encephalocele (HP:0002085)4.04793964
14Abnormality of midbrain morphology (HP:0002418)3.68221538
15Molar tooth sign on MRI (HP:0002419)3.68221538
16Pancreatic cysts (HP:0001737)3.49728649
17Male infertility (HP:0003251)3.48100911
18Infertility (HP:0000789)3.47708514
19Nephronophthisis (HP:0000090)3.43732296
20Abnormality of the nasal mucosa (HP:0000433)3.30354226
21Recurrent sinusitis (HP:0011108)3.30061079
22Cystic liver disease (HP:0006706)3.18882100
23Postaxial foot polydactyly (HP:0001830)3.11858604
24Medial flaring of the eyebrow (HP:0010747)3.04215991
25Abnormality of the anterior horn cell (HP:0006802)2.88650843
26Degeneration of anterior horn cells (HP:0002398)2.88650843
27Chronic sinusitis (HP:0011109)2.84667378
28Chronic hepatic failure (HP:0100626)2.82440034
29Bronchitis (HP:0012387)2.82322930
30Gait imbalance (HP:0002141)2.81018312
31Congenital primary aphakia (HP:0007707)2.78011404
32Recurrent otitis media (HP:0000403)2.77409373
33Abnormality of the renal medulla (HP:0100957)2.66421676
34Anencephaly (HP:0002323)2.52867588
35Tubulointerstitial nephritis (HP:0001970)2.52411138
36Supernumerary spleens (HP:0009799)2.51108755
37Congenital hepatic fibrosis (HP:0002612)2.49596737
38Aplasia/Hypoplasia of the spleen (HP:0010451)2.48915194
39Sclerocornea (HP:0000647)2.48575326
40Atelectasis (HP:0100750)2.48233998
41Nephrogenic diabetes insipidus (HP:0009806)2.44814683
42Aplasia/Hypoplasia of the tongue (HP:0010295)2.39678239
43Preaxial hand polydactyly (HP:0001177)2.33228863
44Asplenia (HP:0001746)2.32696337
45Postaxial hand polydactyly (HP:0001162)2.32506496
46Male pseudohermaphroditism (HP:0000037)2.27253776
47Oculomotor apraxia (HP:0000657)2.19339106
48Abnormality of the lower motor neuron (HP:0002366)2.18316753
49Vaginal atresia (HP:0000148)2.13823690
50Amyotrophic lateral sclerosis (HP:0007354)2.11881178
51Chronic otitis media (HP:0000389)2.10537488
52Genital tract atresia (HP:0001827)2.09333593
53Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.1823024
54Abnormal biliary tract physiology (HP:0012439)1.94754491
55Bile duct proliferation (HP:0001408)1.94754491
56Atrophy/Degeneration involving motor neurons (HP:0007373)1.94634441
57Poor coordination (HP:0002370)1.89777764
58Hyperactive renin-angiotensin system (HP:0000841)1.88445255
59Aganglionic megacolon (HP:0002251)1.81350687
60Median cleft lip (HP:0000161)1.81181022
61Tubular atrophy (HP:0000092)1.78316822
62Hyperglycinemia (HP:0002154)1.72243491
63Anophthalmia (HP:0000528)1.70793928
64Multicystic kidney dysplasia (HP:0000003)1.69845423
65Decreased central vision (HP:0007663)1.68326199
66Retinitis pigmentosa (HP:0000510)1.63388904
67Optic nerve coloboma (HP:0000588)1.60575315
68Holoprosencephaly (HP:0001360)1.57022431
69Nephropathy (HP:0000112)1.55181003
70Abdominal situs inversus (HP:0003363)1.52801631
71Abnormality of abdominal situs (HP:0011620)1.52801631
72Broad foot (HP:0001769)1.52381559
73Absent rod-and cone-mediated responses on ERG (HP:0007688)1.52234423
74Prominent nasal bridge (HP:0000426)1.51883545
75Narrow forehead (HP:0000341)1.45956581
76Bifid scrotum (HP:0000048)1.45832062
77Intestinal atresia (HP:0011100)1.44457864
78Tubulointerstitial abnormality (HP:0001969)1.40506250
79Abnormal drinking behavior (HP:0030082)1.39720780
80Polydipsia (HP:0001959)1.39720780
81Decreased testicular size (HP:0008734)1.39383544
82Stage 5 chronic kidney disease (HP:0003774)1.38333229
83Facial cleft (HP:0002006)1.35015576
84Furrowed tongue (HP:0000221)1.34521713
85Abnormality of macular pigmentation (HP:0008002)1.34243241
86Abnormality of the renal cortex (HP:0011035)1.34002066
87Abnormality of the labia minora (HP:0012880)1.33003466
88Abnormal lung lobation (HP:0002101)1.32950617
89Intellectual disability, moderate (HP:0002342)1.31277674
90Hand muscle atrophy (HP:0009130)1.31162639
91Aplasia/Hypoplasia of the lens (HP:0008063)1.29765851
92Chorioretinal coloboma (HP:0000567)1.26271351
93Specific learning disability (HP:0001328)1.24715850
94Dandy-Walker malformation (HP:0001305)1.24553732
95Bell-shaped thorax (HP:0001591)1.23782559
96Renal salt wasting (HP:0000127)1.23451062
97Renal hypoplasia (HP:0000089)1.22715129
98Highly arched eyebrow (HP:0002553)1.22670065
99Abnormal rod and cone electroretinograms (HP:0008323)1.21882823
100Abolished electroretinogram (ERG) (HP:0000550)1.20366385

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK157.40552857
2BCR3.53835856
3MST43.08222661
4VRK23.06110864
5PBK2.32611618
6PNCK2.23282090
7SRPK12.21673102
8PINK12.13054598
9TTK1.96458588
10DYRK31.91974274
11NME11.83296663
12MAP3K41.74356026
13DYRK21.69352635
14PLK41.68440811
15MAP4K21.67543590
16VRK11.57329478
17CSNK1G31.53416126
18EPHA21.53339641
19CSNK1G21.52077594
20CSNK1G11.51372466
21CSNK1A1L1.51078386
22CCNB11.48942952
23TNIK1.35032131
24NUAK11.33579958
25BCKDK1.33552888
26TRIM281.29522910
27NEK21.29460778
28MAP2K71.29382131
29AURKA1.27807316
30WNK31.19535990
31WEE11.19066746
32STK161.18956608
33PLK31.15031436
34PLK11.14142268
35TESK11.10020254
36PRKCI1.07567635
37CHEK21.07463262
38ERBB31.06300447
39MINK11.05650498
40FLT31.05496805
41CDK91.05454525
42CDC71.05397453
43MAPKAPK31.03024718
44PAK31.01924866
45MAPK131.01461666
46MATK0.97494941
47PLK20.95718995
48ATR0.87710398
49PTK2B0.84048887
50MKNK10.83040860
51EPHB20.80599006
52GRK10.79689630
53SMG10.78034820
54DYRK1A0.76554620
55TAF10.75800321
56MAP3K110.74524968
57ZAK0.74471712
58EPHA30.73364998
59ADRBK20.71829331
60CDK60.69930563
61BMPR1B0.69811893
62PKN20.68536771
63PDK20.65799540
64LRRK20.64511432
65EPHA40.61728079
66ERBB20.60560173
67PIM20.58659818
68CDK190.57879978
69LMTK20.56064615
70ATM0.55941825
71INSRR0.55472748
72CDK40.55208530
73WNK40.54647180
74CDK70.53521664
75PAK10.53168106
76CDK80.52815873
77CSNK1E0.52635247
78EIF2AK10.51758436
79TSSK60.49654557
80DYRK1B0.48464224
81NEK10.46138112
82BRSK20.45852956
83CSNK1A10.45318361
84RPS6KA40.44254183
85CSNK2A10.42710284
86CDK10.41381056
87MAP3K100.41203247
88MAP3K70.40823205
89CDK20.38918758
90CSNK2A20.38819721
91CDK140.38545465
92BRSK10.38527745
93PRKDC0.37763490
94AURKB0.37725697
95CHEK10.37102204
96MARK10.36995630
97DMPK0.33082511
98MAPKAPK50.32373099
99MAP2K40.32265780
100CASK0.32139728

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.80251069
2Huntingtons disease_Homo sapiens_hsa050162.80017000
3Non-homologous end-joining_Homo sapiens_hsa034502.48169189
4Steroid biosynthesis_Homo sapiens_hsa001002.32463749
5Base excision repair_Homo sapiens_hsa034102.29294003
6Glutathione metabolism_Homo sapiens_hsa004802.26561514
7Protein export_Homo sapiens_hsa030602.25461820
8Chemical carcinogenesis_Homo sapiens_hsa052042.25293869
9Phenylalanine metabolism_Homo sapiens_hsa003602.21215055
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.20152803
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.15427252
12Mismatch repair_Homo sapiens_hsa034302.05811202
13Tyrosine metabolism_Homo sapiens_hsa003502.01607610
14Homologous recombination_Homo sapiens_hsa034401.99631857
15Histidine metabolism_Homo sapiens_hsa003401.80509121
16Peroxisome_Homo sapiens_hsa041461.75708140
17Oxidative phosphorylation_Homo sapiens_hsa001901.71689851
18Fatty acid elongation_Homo sapiens_hsa000621.71225355
19Fanconi anemia pathway_Homo sapiens_hsa034601.68671544
20Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.68119437
21Basal transcription factors_Homo sapiens_hsa030221.67310485
22Parkinsons disease_Homo sapiens_hsa050121.64599917
23RNA polymerase_Homo sapiens_hsa030201.62329405
24Propanoate metabolism_Homo sapiens_hsa006401.59776501
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56545364
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.56097109
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56096005
28Spliceosome_Homo sapiens_hsa030401.53369326
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.52374953
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.48429980
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45720481
32Phototransduction_Homo sapiens_hsa047441.42906408
33beta-Alanine metabolism_Homo sapiens_hsa004101.38346940
34DNA replication_Homo sapiens_hsa030301.38152236
35Nucleotide excision repair_Homo sapiens_hsa034201.34598425
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31240621
37Pyruvate metabolism_Homo sapiens_hsa006201.21430114
38Fatty acid metabolism_Homo sapiens_hsa012121.20754591
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14742874
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10431003
41Pyrimidine metabolism_Homo sapiens_hsa002401.04555984
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02516712
43RNA transport_Homo sapiens_hsa030131.02218393
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01772725
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01590375
46Biosynthesis of amino acids_Homo sapiens_hsa012301.00973462
47Purine metabolism_Homo sapiens_hsa002301.00611319
48Ribosome_Homo sapiens_hsa030101.00320998
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00204020
50RNA degradation_Homo sapiens_hsa030180.99069013
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95704360
52Basal cell carcinoma_Homo sapiens_hsa052170.93869424
53Retinol metabolism_Homo sapiens_hsa008300.93440612
54Fatty acid degradation_Homo sapiens_hsa000710.92312598
55Caffeine metabolism_Homo sapiens_hsa002320.91226136
56Metabolic pathways_Homo sapiens_hsa011000.88216470
57Cell cycle_Homo sapiens_hsa041100.83871007
58Cardiac muscle contraction_Homo sapiens_hsa042600.83050367
59Carbon metabolism_Homo sapiens_hsa012000.82615993
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82160164
61Hedgehog signaling pathway_Homo sapiens_hsa043400.80307952
62mRNA surveillance pathway_Homo sapiens_hsa030150.78847967
63Arginine and proline metabolism_Homo sapiens_hsa003300.77008944
64Proteasome_Homo sapiens_hsa030500.76412427
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76150812
66Notch signaling pathway_Homo sapiens_hsa043300.75859750
67Butanoate metabolism_Homo sapiens_hsa006500.74660518
68Alzheimers disease_Homo sapiens_hsa050100.74597154
69Collecting duct acid secretion_Homo sapiens_hsa049660.73208482
70Nicotine addiction_Homo sapiens_hsa050330.71166766
71Oocyte meiosis_Homo sapiens_hsa041140.70151541
72Sulfur relay system_Homo sapiens_hsa041220.68856320
73Linoleic acid metabolism_Homo sapiens_hsa005910.68100985
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64632905
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63480485
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62947901
77Olfactory transduction_Homo sapiens_hsa047400.61808599
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60586906
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.58157389
80N-Glycan biosynthesis_Homo sapiens_hsa005100.57037884
81Starch and sucrose metabolism_Homo sapiens_hsa005000.56301183
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56030458
83Regulation of autophagy_Homo sapiens_hsa041400.52325288
84Taste transduction_Homo sapiens_hsa047420.52209860
85Arachidonic acid metabolism_Homo sapiens_hsa005900.51408708
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.50509590
87Hippo signaling pathway_Homo sapiens_hsa043900.49627878
88Axon guidance_Homo sapiens_hsa043600.46001498
89Tight junction_Homo sapiens_hsa045300.45099310
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44421757
91Selenocompound metabolism_Homo sapiens_hsa004500.44089446
92Sphingolipid metabolism_Homo sapiens_hsa006000.44034615
93Cocaine addiction_Homo sapiens_hsa050300.43526273
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.43522351
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42557425
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.40774733
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40024168
98ABC transporters_Homo sapiens_hsa020100.38909155
99Lysine degradation_Homo sapiens_hsa003100.38181717
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36380085

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