C20ORF24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)4.44913133
2response to peptidoglycan (GO:0032494)4.02260705
3negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.79234906
4protein maturation by protein folding (GO:0022417)3.77840142
5deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.72263457
6neutrophil activation involved in immune response (GO:0002283)3.65222898
7nucleobase-containing small molecule interconversion (GO:0015949)3.30266170
8viral transcription (GO:0019083)3.28877123
9regulation of superoxide anion generation (GO:0032928)3.17525168
10pentose-phosphate shunt (GO:0006098)3.10034735
11pinocytosis (GO:0006907)3.08910509
12GDP-mannose metabolic process (GO:0019673)3.01746613
13negative regulation of interleukin-12 production (GO:0032695)3.00865357
14translational termination (GO:0006415)3.00398645
15pentose metabolic process (GO:0019321)2.95642954
16pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.93998682
17ribosomal large subunit biogenesis (GO:0042273)2.90856321
18lipopolysaccharide-mediated signaling pathway (GO:0031663)2.87837269
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.87021232
20protein targeting to ER (GO:0045047)2.85197848
21antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.78454928
22cotranslational protein targeting to membrane (GO:0006613)2.78195955
23pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.77488887
242-deoxyribonucleotide biosynthetic process (GO:0009265)2.76331578
25deoxyribose phosphate biosynthetic process (GO:0046385)2.76331578
26modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.76164873
27positive regulation by organism of defense response of other organism involved in symbiotic interact2.76164873
28modulation by symbiont of host immune response (GO:0052553)2.76164873
29positive regulation by symbiont of host defense response (GO:0052509)2.76164873
30modulation by symbiont of host defense response (GO:0052031)2.76164873
31modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.76164873
32maturation of SSU-rRNA (GO:0030490)2.76109788
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.75730649
34protein localization to endoplasmic reticulum (GO:0070972)2.74351128
35pyrimidine-containing compound salvage (GO:0008655)2.74305508
36pyrimidine nucleoside salvage (GO:0043097)2.74305508
37respiratory burst (GO:0045730)2.72099079
38translational elongation (GO:0006414)2.72049278
39immunoglobulin mediated immune response (GO:0016064)2.72034884
40COPI coating of Golgi vesicle (GO:0048205)2.71972773
41Golgi transport vesicle coating (GO:0048200)2.71972773
42establishment of protein localization to endoplasmic reticulum (GO:0072599)2.71624683
43glycosphingolipid catabolic process (GO:0046479)2.71567249
44NADPH regeneration (GO:0006740)2.69669984
45negative regulation of myeloid cell apoptotic process (GO:0033033)2.68620961
46NIK/NF-kappaB signaling (GO:0038061)2.68246831
47viral life cycle (GO:0019058)2.68150257
48polyketide metabolic process (GO:0030638)2.64252747
49doxorubicin metabolic process (GO:0044598)2.64252747
50daunorubicin metabolic process (GO:0044597)2.64252747
51negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.64018048
52Arp2/3 complex-mediated actin nucleation (GO:0034314)2.63179570
53detection of other organism (GO:0098543)2.57001683
54nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.55291865
55ribosomal small subunit assembly (GO:0000028)2.54742932
56glycolipid catabolic process (GO:0019377)2.50730883
57protein localization to endosome (GO:0036010)2.49928605
58positive regulation of Cdc42 GTPase activity (GO:0043089)2.49650864
59detection of bacterium (GO:0016045)2.49518870
60ribonucleoprotein complex biogenesis (GO:0022613)2.49358769
61regulation of mast cell degranulation (GO:0043304)2.47932023
62chaperone mediated protein folding requiring cofactor (GO:0051085)2.47281798
63glucose catabolic process (GO:0006007)2.46491899
64positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.43134552
65pyrimidine nucleotide catabolic process (GO:0006244)2.43093773
66regulation of necrotic cell death (GO:0010939)2.33775797
67positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.32106128
68deoxyribonucleotide biosynthetic process (GO:0009263)2.31258403
69cellular protein complex disassembly (GO:0043624)2.31253560
70regulation of leukocyte degranulation (GO:0043300)2.30819391
71translational initiation (GO:0006413)2.29407410
72deoxyribose phosphate catabolic process (GO:0046386)2.29073966
73cellular response to arsenic-containing substance (GO:0071243)2.28414305
74mitochondrial calcium ion transport (GO:0006851)2.27705062
75B cell mediated immunity (GO:0019724)2.26229450
76granulocyte activation (GO:0036230)2.25754100
77deoxyribonucleotide catabolic process (GO:0009264)2.25657979
78guanosine-containing compound biosynthetic process (GO:1901070)2.24945889
79aminoglycoside antibiotic metabolic process (GO:0030647)2.24446385
80regulation of early endosome to late endosome transport (GO:2000641)2.24322475
81nucleotide salvage (GO:0043173)2.23523175
82protein retention in ER lumen (GO:0006621)2.21193893
83glucose 6-phosphate metabolic process (GO:0051156)2.20566382
84regulation of myeloid leukocyte mediated immunity (GO:0002886)2.19565091
85proteasome assembly (GO:0043248)2.19120026
86oligosaccharide catabolic process (GO:0009313)2.18792494
87maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.18600660
88myeloid dendritic cell differentiation (GO:0043011)2.17516032
89regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.16613507
90formation of translation preinitiation complex (GO:0001731)2.16345231
91detection of external biotic stimulus (GO:0098581)2.16278103
92nucleoside salvage (GO:0043174)2.16063524
93positive regulation of leukocyte degranulation (GO:0043302)2.15818916
94amino sugar catabolic process (GO:0046348)2.15700658
95antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.15172031
96myeloid cell homeostasis (GO:0002262)2.14866560
97regulation of translational termination (GO:0006449)2.12782233
98translation (GO:0006412)2.12625043
99positive regulation of monocyte chemotaxis (GO:0090026)2.12156692
100macrophage activation involved in immune response (GO:0002281)2.12132491

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.18221044
2BP1_19119308_ChIP-ChIP_Hs578T_Human2.82200787
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.82144487
4E2F7_22180533_ChIP-Seq_HELA_Human2.59008927
5NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.50927401
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.41347678
7VDR_21846776_ChIP-Seq_THP-1_Human2.39664012
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.36967141
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.20436331
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.15685210
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.03678971
12ZNF263_19887448_ChIP-Seq_K562_Human2.03215677
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.02112658
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.02072167
15TP63_17297297_ChIP-ChIP_HaCaT_Human1.92823698
16MYC_22102868_ChIP-Seq_BL_Human1.78004348
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75339617
18LXR_22292898_ChIP-Seq_THP-1_Human1.67960350
19* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.67620083
20TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66768840
21TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66324423
22ELK3_25401928_ChIP-Seq_HUVEC_Human1.65856045
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65381516
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63276469
25MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59213480
26XRN2_22483619_ChIP-Seq_HELA_Human1.59091768
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.58349040
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56327475
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.54786799
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53716652
31SPI1_23547873_ChIP-Seq_NB4_Human1.53555275
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.51326620
33* ETS1_20019798_ChIP-Seq_JURKAT_Human1.50071222
34VDR_24763502_ChIP-Seq_THP-1_Human1.48130229
35DCP1A_22483619_ChIP-Seq_HELA_Human1.47154168
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46794143
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.46057920
38SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44638754
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44260094
40CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.44218798
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42415955
42RACK7_27058665_Chip-Seq_MCF-7_Human1.41689445
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40937365
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.40827563
45KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.40057404
46NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40035010
47SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39963763
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39046350
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38989758
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.38633713
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.38388392
52GABP_17652178_ChIP-ChIP_JURKAT_Human1.38107181
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.37828243
54MYB_21317192_ChIP-Seq_ERMYB_Mouse1.35355230
55TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35102478
56* GABP_19822575_ChIP-Seq_HepG2_Human1.34884531
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32490575
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31752093
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31053686
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.29366635
61SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27739858
62TFEB_21752829_ChIP-Seq_HELA_Human1.25803003
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25100510
64RUNX1_22412390_ChIP-Seq_EML_Mouse1.24272501
65MAF_26560356_Chip-Seq_TH1_Human1.24248698
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24200647
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.23295883
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22721941
69* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.21246531
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20745936
71NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19933531
72* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19624045
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19024205
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18046569
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14262459
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13525855
77ATF3_27146783_Chip-Seq_COLON_Human1.13254120
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13191153
79UTX_26944678_Chip-Seq_JUKART_Human1.12471658
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12027505
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11066939
82MAF_26560356_Chip-Seq_TH2_Human1.10827868
83CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.10557737
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10465557
85STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10253703
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07442471
87ELF1_20517297_ChIP-Seq_JURKAT_Human1.06714297
88PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06374552
89PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05982484
90BCL6_27268052_Chip-Seq_Bcells_Human1.05352680
91CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04725152
92* P68_20966046_ChIP-Seq_HELA_Human1.04584308
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04314014
94CTCF_18555785_ChIP-Seq_MESCs_Mouse1.03044289
95SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02789043
96POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02637205
97MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01621921
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01602383
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00982850
100KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00470312

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.66799071
2MP0003806_abnormal_nucleotide_metabolis3.18965723
3MP0005058_abnormal_lysosome_morphology3.12992290
4MP0003436_decreased_susceptibility_to2.85501849
5MP0003191_abnormal_cellular_cholesterol2.80081405
6MP0009840_abnormal_foam_cell2.79964756
7MP0002877_abnormal_melanocyte_morpholog2.52746976
8MP0008260_abnormal_autophagy2.40255852
9MP0001835_abnormal_antigen_presentation2.30794028
10MP0009333_abnormal_splenocyte_physiolog2.25166675
11MP0003303_peritoneal_inflammation2.20125505
12MP0009785_altered_susceptibility_to2.17788922
13MP0002148_abnormal_hypersensitivity_rea2.15480576
14MP0002419_abnormal_innate_immunity2.11219652
15MP0000858_altered_metastatic_potential2.06994082
16MP0005025_abnormal_response_to2.00449089
17MP0005464_abnormal_platelet_physiology1.99616795
18MP0006082_CNS_inflammation1.96243647
19MP0010234_abnormal_vibrissa_follicle1.87032185
20MP0004185_abnormal_adipocyte_glucose1.77360390
21MP0005000_abnormal_immune_tolerance1.76517928
22MP0000685_abnormal_immune_system1.72444948
23MP0002139_abnormal_hepatobiliary_system1.71789929
24MP0009379_abnormal_foot_pigmentation1.69791682
25MP0003724_increased_susceptibility_to1.65371209
26MP0000343_altered_response_to1.64863456
27MP0001853_heart_inflammation1.63278012
28MP0000490_abnormal_crypts_of1.63193977
29MP0003453_abnormal_keratinocyte_physiol1.62895041
30MP0002452_abnormal_antigen_presenting1.62522989
31MP0002723_abnormal_immune_serum1.55142072
32MP0003186_abnormal_redox_activity1.54610109
33MP0002796_impaired_skin_barrier1.53609766
34MP0001790_abnormal_immune_system1.53285199
35MP0005387_immune_system_phenotype1.53285199
36MP0001819_abnormal_immune_cell1.53098763
37MP0002420_abnormal_adaptive_immunity1.53007912
38MP0003172_abnormal_lysosome_physiology1.52730419
39MP0004947_skin_inflammation1.51217152
40MP0005671_abnormal_response_to1.51089582
41MP0003693_abnormal_embryo_hatching1.45989420
42MP0003075_altered_response_to1.43889182
43MP0008469_abnormal_protein_level1.43269257
44MP0009764_decreased_sensitivity_to1.42144228
45MP0001800_abnormal_humoral_immune1.41848702
46MP0001845_abnormal_inflammatory_respons1.40073036
47MP0010155_abnormal_intestine_physiology1.35739525
48MP0001533_abnormal_skeleton_physiology1.34607568
49MP0004957_abnormal_blastocyst_morpholog1.32798290
50MP0004233_abnormal_muscle_weight1.31390539
51MP0004858_abnormal_nervous_system1.30840753
52MP0003705_abnormal_hypodermis_morpholog1.30816711
53MP0005501_abnormal_skin_physiology1.29788089
54MP0006036_abnormal_mitochondrial_physio1.23025272
55MP0005319_abnormal_enzyme/_coenzyme1.22495524
56MP0002132_abnormal_respiratory_system1.20002339
57MP0003300_gastrointestinal_ulcer1.19534546
58MP0000716_abnormal_immune_system1.17823522
59MP0002398_abnormal_bone_marrow1.16696652
60MP0005360_urolithiasis1.14531905
61MP0002429_abnormal_blood_cell1.13934281
62MP0009278_abnormal_bone_marrow1.10010050
63MP0003566_abnormal_cell_adhesion1.08813336
64MP0000604_amyloidosis1.08332838
65MP0003123_paternal_imprinting1.06070265
66MP0004264_abnormal_extraembryonic_tissu1.06036619
67MP0003448_altered_tumor_morphology1.05841682
68MP0002405_respiratory_system_inflammati1.05038270
69MP0002998_abnormal_bone_remodeling1.04549514
70MP0005397_hematopoietic_system_phenotyp1.04297701
71MP0001545_abnormal_hematopoietic_system1.04297701
72MP0002722_abnormal_immune_system1.03463697
73MP0003828_pulmonary_edema1.01027638
74MP0003763_abnormal_thymus_physiology1.00236851
75MP0005166_decreased_susceptibility_to0.97626892
76MP0000609_abnormal_liver_physiology0.96995847
77MP0003111_abnormal_nucleus_morphology0.95576429
78MP0000689_abnormal_spleen_morphology0.95530542
79MP0000678_abnormal_parathyroid_gland0.95500431
80MP0004510_myositis0.94427665
81MP0001216_abnormal_epidermal_layer0.92116148
82MP0003656_abnormal_erythrocyte_physiolo0.91928957
83MP0003221_abnormal_cardiomyocyte_apopto0.91706478
84MP0008007_abnormal_cellular_replicative0.90943949
85MP0000465_gastrointestinal_hemorrhage0.89809275
86MP0005666_abnormal_adipose_tissue0.88517725
87MP0009763_increased_sensitivity_to0.87882717
88MP0005365_abnormal_bile_salt0.87012882
89MP0005023_abnormal_wound_healing0.85656395
90MP0005165_increased_susceptibility_to0.85350544
91MP0000750_abnormal_muscle_regeneration0.85315953
92MP0001873_stomach_inflammation0.83565336
93MP0000313_abnormal_cell_death0.83493159
94MP0001727_abnormal_embryo_implantation0.82774913
95MP0003077_abnormal_cell_cycle0.82147397
96MP0005584_abnormal_enzyme/coenzyme_acti0.81498864
97MP0008932_abnormal_embryonic_tissue0.81441619
98MP0001849_ear_inflammation0.81278214
99MP0003866_abnormal_defecation0.80079762
100MP0008875_abnormal_xenobiotic_pharmacok0.79960744

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycosphingolipid metabolism (HP:0004343)4.17863707
2Abnormality of glycolipid metabolism (HP:0010969)4.17863707
3Abnormality of liposaccharide metabolism (HP:0010968)4.17863707
4Abnormality of macrophages (HP:0004311)3.98990223
5Eczematoid dermatitis (HP:0000976)3.41080475
6Recurrent abscess formation (HP:0002722)3.34011472
7Recurrent bacterial skin infections (HP:0005406)3.29639003
8Obstructive lung disease (HP:0006536)3.15210647
9Chronic obstructive pulmonary disease (HP:0006510)3.15210647
10Increased serum ferritin (HP:0003281)3.00037968
11Vertebral compression fractures (HP:0002953)2.91789935
12Increased cerebral lipofuscin (HP:0011813)2.84385055
13Ragged-red muscle fibers (HP:0003200)2.82672362
14Recurrent gram-negative bacterial infections (HP:0005420)2.80029546
15Vacuolated lymphocytes (HP:0001922)2.79534548
16Petechiae (HP:0000967)2.67512920
17Hepatosplenomegaly (HP:0001433)2.67072710
18Purpura (HP:0000979)2.52830717
19Abnormality of aromatic amino acid family metabolism (HP:0004338)2.50301340
20Achilles tendon contracture (HP:0001771)2.47619820
21Progressive neurologic deterioration (HP:0002344)2.47156581
22Increased neuronal autofluorescent lipopigment (HP:0002074)2.46834135
23Rough bone trabeculation (HP:0100670)2.44917829
24Increased muscle lipid content (HP:0009058)2.44315515
25Abnormality of the Achilles tendon (HP:0005109)2.42221205
26Systemic lupus erythematosus (HP:0002725)2.41709295
27Increased intramyocellular lipid droplets (HP:0012240)2.36949076
28Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.36482345
29Increased IgM level (HP:0003496)2.34216577
30Loss of speech (HP:0002371)2.34048637
31Urticaria (HP:0001025)2.33156072
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.31718854
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.31718854
34Mediastinal lymphadenopathy (HP:0100721)2.29557876
35Progressive muscle weakness (HP:0003323)2.26880455
36Microretrognathia (HP:0000308)2.25674612
37Axonal loss (HP:0003447)2.25668614
38Abnormality of iron homeostasis (HP:0011031)2.25624555
39Multiple enchondromatosis (HP:0005701)2.24794753
40Amyloidosis (HP:0011034)2.22740957
41Dysostosis multiplex (HP:0000943)2.19593173
42Hypertensive crisis (HP:0100735)2.19506542
43Abnormal mitochondria in muscle tissue (HP:0008316)2.19357784
44Upper motor neuron abnormality (HP:0002127)2.18497010
45Myositis (HP:0100614)2.18222822
46Renal Fanconi syndrome (HP:0001994)2.16405127
47Elevated erythrocyte sedimentation rate (HP:0003565)2.15936575
48Prolonged neonatal jaundice (HP:0006579)2.14533562
49Distal lower limb muscle weakness (HP:0009053)2.13488907
50Hypokinesia (HP:0002375)2.11856608
51Abnormal trabecular bone morphology (HP:0100671)2.08151077
52Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.07030719
53Trismus (HP:0000211)2.00158347
54Deep venous thrombosis (HP:0002625)1.98149525
55Orchitis (HP:0100796)1.97539702
56Cellulitis (HP:0100658)1.97236945
57Recurrent skin infections (HP:0001581)1.96328308
58Thrombocytosis (HP:0001894)1.94926633
59Microvesicular hepatic steatosis (HP:0001414)1.94889123
60Bone pain (HP:0002653)1.94020481
61Pallor (HP:0000980)1.93139562
62Acute necrotizing encephalopathy (HP:0006965)1.90917193
63Rhabdomyolysis (HP:0003201)1.88009630
64Stomatitis (HP:0010280)1.86875948
65Myocardial infarction (HP:0001658)1.85070992
66Generalized aminoaciduria (HP:0002909)1.84779187
67Abnormality of monocarboxylic acid metabolism (HP:0010996)1.84485204
68Gingivitis (HP:0000230)1.84193083
69Abnormality of the distal phalanges of the toes (HP:0010182)1.83154124
70Distal lower limb amyotrophy (HP:0008944)1.82898222
71Meningitis (HP:0001287)1.80808604
72Personality changes (HP:0000751)1.80345023
73Macrocytic anemia (HP:0001972)1.80145137
74Hyperparathyroidism (HP:0000843)1.79827305
75Aplasia/Hypoplasia of the sacrum (HP:0008517)1.79496694
76Abnormality of cells of the erythroid lineage (HP:0012130)1.77115064
77Mitochondrial inheritance (HP:0001427)1.76335321
78Acute hepatic failure (HP:0006554)1.76049402
79Autoimmune thrombocytopenia (HP:0001973)1.74726180
80Pathologic fracture (HP:0002756)1.73777001
81Hypertriglyceridemia (HP:0002155)1.73618848
82Polygenic inheritance (HP:0010982)1.73512980
83Aplastic anemia (HP:0001915)1.73063712
84Nausea (HP:0002018)1.71973218
85Malnutrition (HP:0004395)1.71587930
86Esophageal neoplasm (HP:0100751)1.71433855
87Neoplasm of head and neck (HP:0012288)1.71433855
88Recurrent viral infections (HP:0004429)1.69969715
89Respiratory difficulties (HP:0002880)1.68137847
90Fasciculations (HP:0002380)1.67510385
91Abnormality of transition element cation homeostasis (HP:0011030)1.67462246
92Recurrent fungal infections (HP:0002841)1.66865906
93Lipid accumulation in hepatocytes (HP:0006561)1.64976974
94Nail dystrophy (HP:0008404)1.64832452
95Abnormality of polysaccharide metabolism (HP:0011012)1.63235595
96Abnormality of glycosaminoglycan metabolism (HP:0004371)1.63235595
97Abnormality of mucopolysaccharide metabolism (HP:0011020)1.63235595
98Hepatocellular necrosis (HP:0001404)1.63090550
99Episodic fever (HP:0001954)1.62628719
100Gastrointestinal infarctions (HP:0005244)1.62553957

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.87468564
2IRAK33.96462329
3TESK23.25456749
4ERN13.02188994
5SMG12.28503886
6MAP2K32.15147393
7SCYL22.08522655
8MAP3K112.08298348
9ARAF2.08286603
10TESK12.06378060
11EPHA22.05275221
12TRIB32.03050888
13IRAK41.88070744
14PRPF4B1.84145772
15TAOK21.80267906
16MST1R1.62184359
17ABL21.59736209
18TYK21.59352681
19RIPK41.59229077
20PAK41.58956052
21TBK11.48667514
22MAP3K31.45484549
23PIM21.43923457
24BUB11.42651206
25SIK11.33399948
26MAP3K121.32028563
27MAP4K11.25586850
28BCKDK1.23960714
29KDR1.23951254
30EIF2AK11.23279306
31STK161.22122704
32VRK21.18522610
33TAOK11.16457685
34ZAP701.15043189
35BLK1.14604998
36LIMK11.11212983
37LRRK21.09493646
38PBK1.08504080
39MAP3K11.07986578
40CSK1.07022943
41IRAK21.05150782
42GRK61.04214025
43MOS0.99009898
44ICK0.97955790
45MAP3K130.95034944
46ILK0.92851749
47MAP3K140.92118444
48MAP3K80.91164699
49TTN0.90152746
50PDK20.88480288
51BRAF0.88346168
52SIK30.85849686
53KSR20.84911814
54RPS6KA40.84881845
55BMPR20.84781078
56PTK60.78180850
57PRKG20.77111741
58MATK0.74125525
59IKBKB0.72465226
60PDPK10.71127947
61CSF1R0.69485915
62RPS6KB20.67577234
63JAK30.64740318
64AURKA0.64415794
65CDK70.62314458
66MAPK110.60510241
67TGFBR20.59415935
68MAP3K60.57743255
69STK100.53481147
70BTK0.52727006
71PTK20.51493162
72PAK10.49973960
73MARK30.49946666
74SRPK10.49918979
75CDK190.49347053
76MAP3K90.49310932
77BMX0.45936268
78IKBKE0.44694369
79NEK10.42815068
80RAF10.42372930
81ERBB40.41678930
82CDK40.40270565
83EPHB10.40119762
84MAPKAPK20.39627816
85CDC70.39385227
86HCK0.39293021
87PRKCI0.39002640
88FGR0.37829012
89PDK10.37621981
90PKN20.36856781
91DAPK10.36655905
92CDK80.35167697
93LYN0.33021833
94LATS20.31717214
95AURKB0.30550324
96PRKCD0.30283970
97LMTK20.29983338
98IRAK10.29826128
99CLK10.29366802
100FES0.28735142

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.12462747
2Proteasome_Homo sapiens_hsa030502.66791259
3Other glycan degradation_Homo sapiens_hsa005112.48216556
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.31633516
5DNA replication_Homo sapiens_hsa030302.02028405
6Pentose phosphate pathway_Homo sapiens_hsa000301.92621414
7Sulfur relay system_Homo sapiens_hsa041221.91795065
8Lysosome_Homo sapiens_hsa041421.83592071
9Galactose metabolism_Homo sapiens_hsa000521.80801106
10Oxidative phosphorylation_Homo sapiens_hsa001901.68309278
11Leishmaniasis_Homo sapiens_hsa051401.67391396
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.66951061
13Sulfur metabolism_Homo sapiens_hsa009201.61261156
14Folate biosynthesis_Homo sapiens_hsa007901.56623175
15Shigellosis_Homo sapiens_hsa051311.54819121
16Osteoclast differentiation_Homo sapiens_hsa043801.52526780
17Salmonella infection_Homo sapiens_hsa051321.51826617
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.51599904
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51060276
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49509570
21Pyrimidine metabolism_Homo sapiens_hsa002401.46423378
22Bladder cancer_Homo sapiens_hsa052191.41240903
23Staphylococcus aureus infection_Homo sapiens_hsa051501.41125885
24Base excision repair_Homo sapiens_hsa034101.40562464
25Fructose and mannose metabolism_Homo sapiens_hsa000511.39452930
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38117679
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.37009987
28Tuberculosis_Homo sapiens_hsa051521.31081557
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.29165071
30Parkinsons disease_Homo sapiens_hsa050121.27926325
31Vibrio cholerae infection_Homo sapiens_hsa051101.26068121
32Legionellosis_Homo sapiens_hsa051341.23181435
33Phagosome_Homo sapiens_hsa041451.23171648
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15615060
35Glutathione metabolism_Homo sapiens_hsa004801.13006050
36Rheumatoid arthritis_Homo sapiens_hsa053231.11467559
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10505354
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.10295251
39Antigen processing and presentation_Homo sapiens_hsa046121.08539943
40Carbon metabolism_Homo sapiens_hsa012001.07896030
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04320150
42Acute myeloid leukemia_Homo sapiens_hsa052211.04226268
43Allograft rejection_Homo sapiens_hsa053301.03847600
44Apoptosis_Homo sapiens_hsa042101.01523608
45Herpes simplex infection_Homo sapiens_hsa051681.00377022
46Pertussis_Homo sapiens_hsa051330.99457731
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98607607
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98366085
49B cell receptor signaling pathway_Homo sapiens_hsa046620.96868023
50Influenza A_Homo sapiens_hsa051640.96089903
51NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95623623
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93441391
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93151035
54Spliceosome_Homo sapiens_hsa030400.92910950
55Biosynthesis of amino acids_Homo sapiens_hsa012300.91600545
56Viral myocarditis_Homo sapiens_hsa054160.91245791
57Epstein-Barr virus infection_Homo sapiens_hsa051690.91201675
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.90352729
59N-Glycan biosynthesis_Homo sapiens_hsa005100.89314032
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88476764
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88176097
62Malaria_Homo sapiens_hsa051440.86388398
63Pancreatic cancer_Homo sapiens_hsa052120.85513006
64Autoimmune thyroid disease_Homo sapiens_hsa053200.85495425
65Asthma_Homo sapiens_hsa053100.85172533
66Graft-versus-host disease_Homo sapiens_hsa053320.84474339
67Alzheimers disease_Homo sapiens_hsa050100.83724448
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83434379
69Toxoplasmosis_Homo sapiens_hsa051450.83147317
70Mismatch repair_Homo sapiens_hsa034300.82823537
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81442843
72Huntingtons disease_Homo sapiens_hsa050160.77796397
73Primary immunodeficiency_Homo sapiens_hsa053400.77228017
74Prion diseases_Homo sapiens_hsa050200.75337023
75Measles_Homo sapiens_hsa051620.75238435
76Hematopoietic cell lineage_Homo sapiens_hsa046400.74498627
77TNF signaling pathway_Homo sapiens_hsa046680.74136849
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73009675
79Chronic myeloid leukemia_Homo sapiens_hsa052200.72535453
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71329358
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.70210777
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69939733
83Collecting duct acid secretion_Homo sapiens_hsa049660.67572274
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67273226
85Hepatitis B_Homo sapiens_hsa051610.67131161
86Non-small cell lung cancer_Homo sapiens_hsa052230.64091844
87Phenylalanine metabolism_Homo sapiens_hsa003600.63498339
88VEGF signaling pathway_Homo sapiens_hsa043700.63437718
89Hepatitis C_Homo sapiens_hsa051600.63409288
90Viral carcinogenesis_Homo sapiens_hsa052030.61430135
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58440156
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55670779
93Thyroid cancer_Homo sapiens_hsa052160.55208359
94Vitamin B6 metabolism_Homo sapiens_hsa007500.51810649
95Endocytosis_Homo sapiens_hsa041440.50807274
96RNA polymerase_Homo sapiens_hsa030200.49181694
97Nucleotide excision repair_Homo sapiens_hsa034200.47642029
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.47404860
99Chemokine signaling pathway_Homo sapiens_hsa040620.45596241
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.42955662

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