C1RL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.43136249
2L-phenylalanine catabolic process (GO:0006559)7.43136249
3L-phenylalanine metabolic process (GO:0006558)7.15479320
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.15479320
5aromatic amino acid family catabolic process (GO:0009074)6.77111090
6indole-containing compound catabolic process (GO:0042436)6.20854120
7indolalkylamine catabolic process (GO:0046218)6.20854120
8tryptophan catabolic process (GO:0006569)6.20854120
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.19164723
10kynurenine metabolic process (GO:0070189)6.03849588
11bile acid biosynthetic process (GO:0006699)5.90067145
12tryptophan metabolic process (GO:0006568)5.82175879
13glyoxylate metabolic process (GO:0046487)5.73298264
14sulfur amino acid catabolic process (GO:0000098)5.61630331
15alpha-linolenic acid metabolic process (GO:0036109)5.56199711
16urea cycle (GO:0000050)5.52262625
17urea metabolic process (GO:0019627)5.52262625
18negative regulation of fibrinolysis (GO:0051918)5.49369086
19high-density lipoprotein particle remodeling (GO:0034375)5.45013383
20peptidyl-glutamic acid carboxylation (GO:0017187)5.37547803
21protein carboxylation (GO:0018214)5.37547803
22cysteine metabolic process (GO:0006534)5.33459771
23complement activation, alternative pathway (GO:0006957)5.32707680
24regulation of fibrinolysis (GO:0051917)5.30171134
25regulation of protein activation cascade (GO:2000257)5.28735341
26serine family amino acid catabolic process (GO:0009071)5.08095555
27nitrogen cycle metabolic process (GO:0071941)5.07883652
28bile acid metabolic process (GO:0008206)5.00539659
29regulation of complement activation (GO:0030449)4.94279896
30fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.94071312
31aromatic amino acid family metabolic process (GO:0009072)4.91345953
32coenzyme catabolic process (GO:0009109)4.87324817
33reverse cholesterol transport (GO:0043691)4.75539687
34regulation of cholesterol esterification (GO:0010872)4.75009848
35regulation of triglyceride catabolic process (GO:0010896)4.73913602
36homocysteine metabolic process (GO:0050667)4.69092724
37plasma lipoprotein particle remodeling (GO:0034369)4.67100736
38protein-lipid complex remodeling (GO:0034368)4.67100736
39macromolecular complex remodeling (GO:0034367)4.67100736
40tyrosine metabolic process (GO:0006570)4.63782052
41alpha-amino acid catabolic process (GO:1901606)4.59575405
42amino-acid betaine metabolic process (GO:0006577)4.54793478
43acylglycerol homeostasis (GO:0055090)4.53029617
44triglyceride homeostasis (GO:0070328)4.53029617
45cellular modified amino acid catabolic process (GO:0042219)4.48631881
46phospholipid efflux (GO:0033700)4.47072342
47lysine catabolic process (GO:0006554)4.46677230
48lysine metabolic process (GO:0006553)4.46677230
49negative regulation of sterol transport (GO:0032372)4.46239822
50negative regulation of cholesterol transport (GO:0032375)4.46239822
51glycine metabolic process (GO:0006544)4.41345780
52negative regulation of protein activation cascade (GO:2000258)4.37913938
53indolalkylamine metabolic process (GO:0006586)4.37305451
54bile acid and bile salt transport (GO:0015721)4.31540597
55imidazole-containing compound metabolic process (GO:0052803)4.30593400
56cellular amino acid catabolic process (GO:0009063)4.30087851
57cellular biogenic amine catabolic process (GO:0042402)4.30049465
58amine catabolic process (GO:0009310)4.30049465
59plasma lipoprotein particle clearance (GO:0034381)4.29393036
60cellular ketone body metabolic process (GO:0046950)4.23235288
61exogenous drug catabolic process (GO:0042738)4.22195507
62serine family amino acid metabolic process (GO:0009069)4.16587187
63cellular glucuronidation (GO:0052695)4.14702025
64epoxygenase P450 pathway (GO:0019373)4.12751243
65benzene-containing compound metabolic process (GO:0042537)4.09357809
66cholesterol efflux (GO:0033344)4.08964852
67ethanol oxidation (GO:0006069)4.06054014
68glutamate metabolic process (GO:0006536)4.04761837
69cofactor catabolic process (GO:0051187)4.02876926
70negative regulation of complement activation (GO:0045916)4.01720031
71serine family amino acid biosynthetic process (GO:0009070)4.01209644
72detection of molecule of bacterial origin (GO:0032490)4.01101624
73fibrinolysis (GO:0042730)3.93894778
74low-density lipoprotein particle remodeling (GO:0034374)3.91815416
75arginine metabolic process (GO:0006525)3.90521738
76plasma lipoprotein particle assembly (GO:0034377)3.88312627
77blood coagulation, intrinsic pathway (GO:0007597)3.88126028
78omega-hydroxylase P450 pathway (GO:0097267)3.86469981
79regulation of humoral immune response (GO:0002920)3.85961334
80aldehyde catabolic process (GO:0046185)3.85810969
81dicarboxylic acid biosynthetic process (GO:0043650)3.80778059
82positive regulation of triglyceride lipase activity (GO:0061365)3.74947094
83positive regulation of lipoprotein lipase activity (GO:0051006)3.74947094
84carboxylic acid catabolic process (GO:0046395)3.74896313
85organic acid catabolic process (GO:0016054)3.74896313
86regulation of apoptotic cell clearance (GO:2000425)3.72613653
87acute-phase response (GO:0006953)3.72019478
88cytolysis (GO:0019835)3.69799390
89drug catabolic process (GO:0042737)3.69726942
90regulation of plasminogen activation (GO:0010755)3.68387437
91very-low-density lipoprotein particle assembly (GO:0034379)3.67626706
92glucuronate metabolic process (GO:0019585)3.66468538
93uronic acid metabolic process (GO:0006063)3.66468538
94negative regulation of humoral immune response (GO:0002921)3.65624694
95ketone body metabolic process (GO:1902224)3.65490641
96heme transport (GO:0015886)3.64790674
97cholesterol homeostasis (GO:0042632)3.64618554
98negative regulation of lipase activity (GO:0060192)3.64445745
99detection of external biotic stimulus (GO:0098581)3.63808828
100positive regulation of lipid catabolic process (GO:0050996)3.63416816
101* protein activation cascade (GO:0072376)3.63221509
102short-chain fatty acid metabolic process (GO:0046459)3.62378566
103antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.62229726
104phospholipid homeostasis (GO:0055091)3.59582268
105sterol homeostasis (GO:0055092)3.58776854
106NAD biosynthetic process (GO:0009435)3.58138577
107* complement activation, classical pathway (GO:0006958)3.57507320
108* complement activation (GO:0006956)3.57177338
109flavonoid metabolic process (GO:0009812)3.55978323
110acetyl-CoA metabolic process (GO:0006084)3.55590366
111plasma lipoprotein particle organization (GO:0071827)3.55136016
112pyridine nucleotide biosynthetic process (GO:0019363)3.54999665
113nicotinamide nucleotide biosynthetic process (GO:0019359)3.54999665
114detection of other organism (GO:0098543)3.48855562
115antigen processing and presentation of endogenous antigen (GO:0019883)3.47354982
116detection of bacterium (GO:0016045)3.37762420
117opsonization (GO:0008228)3.37219303
118antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.35451194
119disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.33266661
120killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.33266661
121ethanol metabolic process (GO:0006067)3.32440804
122antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.30160940
123positive regulation of blood coagulation (GO:0030194)3.22316565
124positive regulation of hemostasis (GO:1900048)3.22316565
125detection of biotic stimulus (GO:0009595)3.17398362
126negative regulation of hemostasis (GO:1900047)3.16522253
127negative regulation of blood coagulation (GO:0030195)3.16522253
128leukocyte migration involved in inflammatory response (GO:0002523)3.09037167
129modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.06129636
130modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.06129636
131positive regulation by organism of defense response of other organism involved in symbiotic interact3.06129636
132modulation by symbiont of host immune response (GO:0052553)3.06129636
133positive regulation by symbiont of host defense response (GO:0052509)3.06129636
134modulation by symbiont of host defense response (GO:0052031)3.06129636
135negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.05005450
136negative regulation of cell killing (GO:0031342)3.05005450
137positive regulation of coagulation (GO:0050820)2.95541864
138negative regulation of coagulation (GO:0050819)2.88302832
139acute inflammatory response (GO:0002526)2.88036338
140regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.85936210
141negative regulation of wound healing (GO:0061045)2.82422623
142intestinal cholesterol absorption (GO:0030299)2.81108278
143drug metabolic process (GO:0017144)2.80956818
144positive regulation of extracellular matrix organization (GO:1903055)2.76869485
145macrophage activation involved in immune response (GO:0002281)2.74743545
146regulation of acute inflammatory response (GO:0002673)2.74523043
147hormone catabolic process (GO:0042447)2.72324761
148positive regulation of gamma-delta T cell activation (GO:0046645)2.67823047
149response to mercury ion (GO:0046689)2.66088467
150cellular extravasation (GO:0045123)2.65987304
151negative regulation of B cell mediated immunity (GO:0002713)2.60678501
152negative regulation of immunoglobulin mediated immune response (GO:0002890)2.60678501
153negative regulation of lymphocyte mediated immunity (GO:0002707)2.58443229

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.31051349
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.15510660
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.95965824
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.38860969
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.29923644
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.05100422
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.93999636
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.06224657
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.02307437
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7521623
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96938794
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.92785260
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.92407805
14VDR_21846776_ChIP-Seq_THP-1_Human1.87556726
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.85886142
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.85612269
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.83556067
18IRF8_21731497_ChIP-ChIP_J774_Mouse1.82843102
19VDR_24763502_ChIP-Seq_THP-1_Human1.82248335
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.81756259
21TP63_17297297_ChIP-ChIP_HaCaT_Human1.79193167
22IRF8_27001747_Chip-Seq_BMDM_Mouse1.77861759
23KDM2B_26808549_Chip-Seq_SUP-B15_Human1.71015123
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70364394
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69649601
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.67647752
27SPI1_23127762_ChIP-Seq_K562_Human1.51144914
28TCF7_22412390_ChIP-Seq_EML_Mouse1.50072484
29FOXA2_19822575_ChIP-Seq_HepG2_Human1.49084148
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.46782227
31GATA2_21666600_ChIP-Seq_HMVEC_Human1.46318934
32GATA1_22025678_ChIP-Seq_K562_Human1.42723079
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42480422
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41396411
35MAF_26560356_Chip-Seq_TH1_Human1.40658318
36RUNX_20019798_ChIP-Seq_JUKART_Human1.39974761
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39289913
38HTT_18923047_ChIP-ChIP_STHdh_Human1.38949253
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.38535058
40HNF4A_19822575_ChIP-Seq_HepG2_Human1.37815498
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36620883
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36446157
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.35431045
44CLOCK_20551151_ChIP-Seq_293T_Human1.34419855
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.33519206
46RXRA_24833708_ChIP-Seq_LIVER_Mouse1.30220294
47STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.29615280
48KDM2B_26808549_Chip-Seq_DND41_Human1.29216261
49RACK7_27058665_Chip-Seq_MCF-7_Human1.27962852
50IRF8_22096565_ChIP-ChIP_GC-B_Human1.27092818
51UTX_26944678_Chip-Seq_JUKART_Human1.23509852
52IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16130925
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.15579530
54BP1_19119308_ChIP-ChIP_Hs578T_Human1.14895727
55VDR_24787735_ChIP-Seq_THP-1_Human1.12614202
56STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11202973
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09470845
58* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08686772
59ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07392099
60GATA1_19941826_ChIP-Seq_K562_Human1.06478452
61SPI1_23547873_ChIP-Seq_NB4_Human1.06301425
62ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05291204
63P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04937148
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04149417
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03631287
66* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03556724
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03405129
68* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03130453
69MAF_26560356_Chip-Seq_TH2_Human1.01889027
70SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97955486
71* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97882184
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96200794
73TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95294575
74MYB_26560356_Chip-Seq_TH1_Human0.94378804
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93547702
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93468249
77EGR1_19374776_ChIP-ChIP_THP-1_Human0.93397932
78PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92626128
79* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92424162
80* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92134069
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92095703
82MYC_22102868_ChIP-Seq_BL_Human0.91205456
83KDM2B_26808549_Chip-Seq_K562_Human0.90797630
84IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.90745810
85Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.90487449
86SMC4_20622854_ChIP-Seq_HELA_Human0.90011863
87ESR1_20079471_ChIP-ChIP_T-47D_Human0.89461819
88BCL6_27268052_Chip-Seq_Bcells_Human0.88064453
89* KDM2B_26808549_Chip-Seq_JURKAT_Human0.87779855
90GATA4_25053715_ChIP-Seq_YYC3_Human0.86515115
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.84971044
92NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.84117104
93RARG_19884340_ChIP-ChIP_MEFs_Mouse0.81509754
94PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81342629
95RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.79960843
96RARA_24833708_ChIP-Seq_LIVER_Mouse0.78723281
97KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78567167
98CDX2_20551321_ChIP-Seq_CACO-2_Human0.77293187
99KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.76268451
100KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.76268451
101KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.76268451
102CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75807332
103* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.75749541
104SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73065189
105ESR2_21235772_ChIP-Seq_MCF-7_Human0.72951829
106AUTS2_25519132_ChIP-Seq_293T-REX_Human0.71968956
107SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.71289742
108BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71146198
109ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.69241234
110* RARB_24833708_ChIP-Seq_LIVER_Mouse0.68810150
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.68584883
112IRF1_19129219_ChIP-ChIP_H3396_Human0.67692772
113ESET_19884257_ChIP-Seq_ESCs_Mouse0.63668179
114AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.61700266
115LXR_22292898_ChIP-Seq_THP-1_Human0.61577067
116SALL4_18804426_ChIP-ChIP_XEN_Mouse0.60356641
117* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.57521750
118CEBPB_22108803_ChIP-Seq_LS180_Human0.56964053
119AR_20517297_ChIP-Seq_VCAP_Human0.56453585
120ESR1_21235772_ChIP-Seq_MCF-7_Human0.55913968
121NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.55721163
122NRF2_20460467_ChIP-Seq_MEFs_Mouse0.55721163
123POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.54989823
124* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.54475447
125FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.51283759
126NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.50975739
127FOXO3_23340844_ChIP-Seq_DLD1_Human0.50094965
128FOXA1_25552417_ChIP-Seq_VCAP_Human0.49333422
129FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.48628606
130CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.48429863
131SCL_19346495_ChIP-Seq_HPC-7_Human0.48194862
132* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.48079492
133GATA1_19941827_ChIP-Seq_MEL_Mouse0.47844415
134SPI1_26923725_Chip-Seq_HPCs_Mouse0.46656523
135EGR1_19032775_ChIP-ChIP_M12_Human0.46115003
136* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45814000
137GATA6_25053715_ChIP-Seq_YYC3_Human0.45580486
138GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.44433624
139MYC_19915707_ChIP-ChIP_AK7_Human0.44188247
140BRD4_27068464_Chip-Seq_AML-cells_Mouse0.43646494
141PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43358076
142SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.43256389
143RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.42927333
144* STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.42146903
145SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.41829862
146BCOR_27268052_Chip-Seq_Bcells_Human0.41413964
147PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.40879408
148PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.40755064
149P53_21459846_ChIP-Seq_SAOS-2_Human0.39763746
150STAT1_17558387_ChIP-Seq_HELA_Human0.39746863
151MYC_27129775_Chip-Seq_CORNEA_Mouse0.39614007
152TCF3_18692474_ChIP-Seq_MEFs_Mouse0.39508144
153* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.39031946
154CSB_26484114_Chip-Seq_FIBROBLAST_Human0.38738048
155GATA2_19941826_ChIP-Seq_K562_Human0.38525699
156ERG_20517297_ChIP-Seq_VCAP_Human0.38468660
157NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.38314259
158FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.37913807
159GATA3_24758297_ChIP-Seq_MCF-7_Human0.37632746

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.11387648
2MP0005360_urolithiasis7.34986481
3MP0005085_abnormal_gallbladder_physiolo6.34244418
4MP0005365_abnormal_bile_salt6.16441980
5MP0008875_abnormal_xenobiotic_pharmacok4.94116882
6MP0003806_abnormal_nucleotide_metabolis4.18920190
7MP0003252_abnormal_bile_duct3.80758455
8MP0010329_abnormal_lipoprotein_level3.50298014
9MP0009840_abnormal_foam_cell3.14616254
10MP0005083_abnormal_biliary_tract3.14567821
11MP0005332_abnormal_amino_acid2.72229519
12MP0003195_calcinosis2.68432636
13MP0001666_abnormal_nutrient_absorption2.65735926
14MP0003191_abnormal_cellular_cholesterol2.35453268
15MP0003300_gastrointestinal_ulcer2.19057016
16MP0000609_abnormal_liver_physiology2.17743366
17MP0004019_abnormal_vitamin_homeostasis2.09387684
18MP0002118_abnormal_lipid_homeostasis2.05719255
19MP0008438_abnormal_cutaneous_collagen2.00490391
20MP0002419_abnormal_innate_immunity1.99689713
21MP0003868_abnormal_feces_composition1.93435963
22MP0005319_abnormal_enzyme/_coenzyme1.92944021
23MP0003011_delayed_dark_adaptation1.91887439
24MP0003303_peritoneal_inflammation1.91585013
25MP0000685_abnormal_immune_system1.89993252
26MP0002138_abnormal_hepatobiliary_system1.84088915
27MP0001835_abnormal_antigen_presentation1.83328317
28MP0005025_abnormal_response_to1.79199274
29MP0001533_abnormal_skeleton_physiology1.68462090
30MP0001764_abnormal_homeostasis1.64081395
31MP0001958_emphysema1.63483779
32MP0001790_abnormal_immune_system1.55097434
33MP0005387_immune_system_phenotype1.55097434
34MP0005584_abnormal_enzyme/coenzyme_acti1.55087131
35MP0005058_abnormal_lysosome_morphology1.53910029
36MP0009697_abnormal_copulation1.50655443
37MP0003172_abnormal_lysosome_physiology1.47549085
38MP0001800_abnormal_humoral_immune1.44187293
39MP0002254_reproductive_system_inflammat1.42126966
40MP0003186_abnormal_redox_activity1.41293048
41MP0005451_abnormal_body_composition1.37958169
42MP0000858_altered_metastatic_potential1.35036120
43MP0003705_abnormal_hypodermis_morpholog1.34729937
44MP0005000_abnormal_immune_tolerance1.34046509
45MP0002933_joint_inflammation1.33500679
46MP0010155_abnormal_intestine_physiology1.32091325
47MP0005023_abnormal_wound_healing1.29937443
48MP0002405_respiratory_system_inflammati1.24938293
49MP0003566_abnormal_cell_adhesion1.24750708
50MP0009643_abnormal_urine_homeostasis1.24284587
51MP0003656_abnormal_erythrocyte_physiolo1.23567573
52MP0003279_aneurysm1.22847027
53MP0002723_abnormal_immune_serum1.22548905
54MP0000598_abnormal_liver_morphology1.22076684
55MP0005647_abnormal_sex_gland1.19816115
56MP0009764_decreased_sensitivity_to1.17631027
57MP0002998_abnormal_bone_remodeling1.15129226
58MP0008260_abnormal_autophagy1.14123130
59MP0002452_abnormal_antigen_presenting1.13674106
60MP0003828_pulmonary_edema1.13542412
61MP0001851_eye_inflammation1.12918643
62MP0006054_spinal_hemorrhage1.10734474
63MP0002420_abnormal_adaptive_immunity1.08879118
64MP0005503_abnormal_tendon_morphology1.08685942
65MP0005275_abnormal_skin_tensile1.08362465
66MP0001819_abnormal_immune_cell1.08178136
67MP0009763_increased_sensitivity_to1.05510098
68MP0010368_abnormal_lymphatic_system1.04889513
69MP0003183_abnormal_peptide_metabolism1.04572430
70MP0004947_skin_inflammation1.03070886
71MP0002148_abnormal_hypersensitivity_rea0.99933497
72MP0008469_abnormal_protein_level0.97257856
73MP0001915_intracranial_hemorrhage0.97214372
74MP0004858_abnormal_nervous_system0.94502491
75MP0004272_abnormal_basement_membrane0.93966424
76MP0000767_abnormal_smooth_muscle0.92276366
77MP0003091_abnormal_cell_migration0.91942456
78MP0008004_abnormal_stomach_pH0.91800640
79MP0005409_darkened_coat_color0.90517141
80MP0005636_abnormal_mineral_homeostasis0.90094312
81MP0005670_abnormal_white_adipose0.89887820
82MP0000465_gastrointestinal_hemorrhage0.89723332
83MP0006036_abnormal_mitochondrial_physio0.89308497
84MP0000604_amyloidosis0.89188263
85MP0005390_skeleton_phenotype0.87564755
86MP0009642_abnormal_blood_homeostasis0.85821200
87MP0005376_homeostasis/metabolism_phenot0.84573065
88MP0005397_hematopoietic_system_phenotyp0.84552814
89MP0001545_abnormal_hematopoietic_system0.84552814
90MP0009765_abnormal_xenobiotic_induced0.83544686
91MP0002166_altered_tumor_susceptibility0.83521299
92MP0003763_abnormal_thymus_physiology0.82948362
93MP0003045_fibrosis0.82024415
94MP0003866_abnormal_defecation0.80698598
95MP0005076_abnormal_cell_differentiation0.80350212
96MP0006035_abnormal_mitochondrial_morpho0.80135041
97MP0005084_abnormal_gallbladder_morpholo0.79791869
98MP0009278_abnormal_bone_marrow0.78807589
99MP0005408_hypopigmentation0.78551827
100MP0005220_abnormal_exocrine_pancreas0.78515909
101MP0000716_abnormal_immune_system0.77783351
102MP0009333_abnormal_splenocyte_physiolog0.75435663
103MP0002876_abnormal_thyroid_physiology0.74671251
104MP0002078_abnormal_glucose_homeostasis0.73799580
105MP0003436_decreased_susceptibility_to0.71643861
106MP0005266_abnormal_metabolism0.71485193
107MP0005334_abnormal_fat_pad0.68865492
108MP0002971_abnormal_brown_adipose0.67446475
109MP0004264_abnormal_extraembryonic_tissu0.64024952
110MP0006082_CNS_inflammation0.63443972
111MP0005075_abnormal_melanosome_morpholog0.63253580
112MP0004381_abnormal_hair_follicle0.62708793
113MP0003724_increased_susceptibility_to0.62665387
114MP0005535_abnormal_body_temperature0.61730976
115MP0004782_abnormal_surfactant_physiolog0.60736087
116MP0005464_abnormal_platelet_physiology0.59322112
117MP0003690_abnormal_glial_cell0.59272087
118MP0000639_abnormal_adrenal_gland0.58571148
119MP0005448_abnormal_energy_balance0.54803866
120MP0001661_extended_life_span0.54481646
121MP0004130_abnormal_muscle_cell0.54255970
122MP0001756_abnormal_urination0.54126224
123MP0002132_abnormal_respiratory_system0.53690975
124MP0009053_abnormal_anal_canal0.50346121
125MP0005248_abnormal_Harderian_gland0.49423010
126MP0002928_abnormal_bile_duct0.47852671
127MP0002136_abnormal_kidney_physiology0.47092718
128MP0008873_increased_physiological_sensi0.45935702
129MP0003075_altered_response_to0.45128359
130MP0003638_abnormal_response/metabolism_0.45077599
131MP0009115_abnormal_fat_cell0.42780104
132MP0005395_other_phenotype0.42518677
133MP0008874_decreased_physiological_sensi0.41938213
134MP0002970_abnormal_white_adipose0.41881696
135MP0001853_heart_inflammation0.41486137
136MP0004883_abnormal_blood_vessel0.39133919
137MP0001845_abnormal_inflammatory_respons0.38434712
138MP0000249_abnormal_blood_vessel0.37170531
139MP0005666_abnormal_adipose_tissue0.36934120
140MP0003953_abnormal_hormone_level0.36865889
141MP0005166_decreased_susceptibility_to0.36610529
142MP0003718_maternal_effect0.36073997
143MP0001243_abnormal_dermal_layer0.35573156
144MP0002796_impaired_skin_barrier0.35510234
145MP0003329_amyloid_beta_deposits0.34943255
146MP0008872_abnormal_physiological_respon0.33866060
147MP0005164_abnormal_response_to0.32142656
148MP0002332_abnormal_exercise_endurance0.28936910
149MP0009785_altered_susceptibility_to0.28891779
150MP0009384_cardiac_valve_regurgitation0.28280227
151MP0009672_abnormal_birth_weight0.26983711
152MP0002168_other_aberrant_phenotype0.26919551
153MP0001881_abnormal_mammary_gland0.26716815
154MP0002060_abnormal_skin_morphology0.26654228
155MP0002135_abnormal_kidney_morphology0.25809265

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.31387682
2Intrahepatic cholestasis (HP:0001406)7.22013131
3Deep venous thrombosis (HP:0002625)7.20960699
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.50924154
5Prolonged partial thromboplastin time (HP:0003645)6.50397680
6Xanthomatosis (HP:0000991)6.14152061
7Hypobetalipoproteinemia (HP:0003563)6.10869023
8Hyperlipoproteinemia (HP:0010980)5.42193997
9Complement deficiency (HP:0004431)5.38238707
10Joint hemorrhage (HP:0005261)4.97526226
11Hypolipoproteinemia (HP:0010981)4.63206178
12Hyperammonemia (HP:0001987)4.56756722
13Abnormality of the common coagulation pathway (HP:0010990)4.44681259
14Hyperglycinemia (HP:0002154)4.43547664
15Epidermoid cyst (HP:0200040)4.26191885
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.24476337
17Abnormality of the intrinsic pathway (HP:0010989)4.22199707
18Ketosis (HP:0001946)4.21843654
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.19205706
20Abnormality of methionine metabolism (HP:0010901)4.17245723
21Fat malabsorption (HP:0002630)4.13067636
22Hypoalphalipoproteinemia (HP:0003233)4.12108809
23Hyperglycinuria (HP:0003108)4.10783337
24Myositis (HP:0100614)4.09670264
25Abnormality of aspartate family amino acid metabolism (HP:0010899)4.02774219
26Abnormality of glycine metabolism (HP:0010895)4.01190263
27Abnormality of serine family amino acid metabolism (HP:0010894)4.01190263
28Abnormality of complement system (HP:0005339)4.00219476
29Abnormality of glutamine family amino acid metabolism (HP:0010902)3.98380755
30Orchitis (HP:0100796)3.88848218
31Abnormality of pyrimidine metabolism (HP:0004353)3.80673515
32Eczematoid dermatitis (HP:0000976)3.79060411
33Hypochromic microcytic anemia (HP:0004840)3.76356026
34Hypoglycemic coma (HP:0001325)3.65311538
35Conjugated hyperbilirubinemia (HP:0002908)3.63636778
36Hypercholesterolemia (HP:0003124)3.54541525
37Peritonitis (HP:0002586)3.48919277
38Optic neuritis (HP:0100653)3.34661406
39Retrobulbar optic neuritis (HP:0100654)3.34661406
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.31400227
41Abnormality of fatty-acid metabolism (HP:0004359)3.30857805
42Hyperbilirubinemia (HP:0002904)3.30501698
43Steatorrhea (HP:0002570)3.19323062
44Delayed CNS myelination (HP:0002188)3.12126764
45Abnormality of nucleobase metabolism (HP:0010932)3.08879651
46Protrusio acetabuli (HP:0003179)3.03021481
47Abnormality of serum amino acid levels (HP:0003112)3.01507309
48Gastrointestinal infarctions (HP:0005244)3.01054097
49Ketoacidosis (HP:0001993)2.99805572
50Myocardial infarction (HP:0001658)2.97708690
51Spontaneous abortion (HP:0005268)2.94475046
52Skin nodule (HP:0200036)2.91617183
53Hepatocellular carcinoma (HP:0001402)2.89301567
54Recurrent abscess formation (HP:0002722)2.86137481
55Systemic lupus erythematosus (HP:0002725)2.85177240
56Metabolic acidosis (HP:0001942)2.83063502
57Purpura (HP:0000979)2.80791236
58Pulmonary embolism (HP:0002204)2.74955272
59Abnormality of purine metabolism (HP:0004352)2.72982719
60Abnormality of macrophages (HP:0004311)2.71668152
61Epistaxis (HP:0000421)2.69906509
62Abnormality of dicarboxylic acid metabolism (HP:0010995)2.64379691
63Dicarboxylic aciduria (HP:0003215)2.64379691
64Elevated erythrocyte sedimentation rate (HP:0003565)2.64261799
65Gout (HP:0001997)2.63940146
66Recurrent gram-negative bacterial infections (HP:0005420)2.62440463
67Lethargy (HP:0001254)2.56120046
68Gingivitis (HP:0000230)2.55992683
69Spontaneous hematomas (HP:0007420)2.53547475
70Vascular calcification (HP:0004934)2.52724376
71Aortic aneurysm (HP:0004942)2.51234864
72Prolonged bleeding time (HP:0003010)2.48327225
73Keratoconjunctivitis sicca (HP:0001097)2.47580962
74Malnutrition (HP:0004395)2.46079120
75Amyloidosis (HP:0011034)2.44477630
76Glomerulonephritis (HP:0000099)2.44339073
77Hypochromic anemia (HP:0001931)2.43242792
78Gingival bleeding (HP:0000225)2.40574646
79Recurrent bacterial skin infections (HP:0005406)2.36603397
80Spastic diplegia (HP:0001264)2.35973418
81Abnormal gallbladder morphology (HP:0012437)2.35779625
82Irritability (HP:0000737)2.35330892
83Acanthocytosis (HP:0001927)2.34288866
84Cholelithiasis (HP:0001081)2.31350510
85Hypoglycemic seizures (HP:0002173)2.29926426
86Menorrhagia (HP:0000132)2.28343142
87Urinary glycosaminoglycan excretion (HP:0003541)2.26828584
88Mucopolysacchariduria (HP:0008155)2.26828584
89Hyperinsulinemic hypoglycemia (HP:0000825)2.26285329
90Vascular tortuosity (HP:0004948)2.25379662
91Polycythemia (HP:0001901)2.24889519
92Keratoconjunctivitis (HP:0001096)2.23936044
93Meningitis (HP:0001287)2.23382267
94Cardiovascular calcification (HP:0011915)2.23295519
95Mitral stenosis (HP:0001718)2.23262042
96Pancreatitis (HP:0001733)2.22344701
97Arterial thrombosis (HP:0004420)2.21810656
98Cerebral edema (HP:0002181)2.20271703
99Neonatal onset (HP:0003623)2.19783481
100Abnormal cartilage morphology (HP:0002763)2.18829828
101Abnormality of glycosaminoglycan metabolism (HP:0004371)2.18280587
102Abnormality of mucopolysaccharide metabolism (HP:0011020)2.18280587
103Abnormality of polysaccharide metabolism (HP:0011012)2.18280587
104Cholecystitis (HP:0001082)2.17766584
105Abnormal gallbladder physiology (HP:0012438)2.17766584
106Enlarged kidneys (HP:0000105)2.16545195
107Hemoptysis (HP:0002105)2.14678525
108Esophageal varix (HP:0002040)2.14410292
109Vomiting (HP:0002013)2.12788626
110Cervical subluxation (HP:0003308)2.12383281
111Generalized aminoaciduria (HP:0002909)2.11801254
112Increased IgE level (HP:0003212)2.11098802
113Arterial tortuosity (HP:0005116)2.11072387
114Thrombophlebitis (HP:0004418)2.10540956
115Aortic dissection (HP:0002647)2.08632391
116Sensorimotor neuropathy (HP:0007141)2.05785934
117Vasculitis (HP:0002633)2.03506613
118Brushfield spots (HP:0001088)2.03427582
119Recurrent skin infections (HP:0001581)2.02582830
120Abnormality of the peritoneum (HP:0002585)2.02463735
121Abnormality of iron homeostasis (HP:0011031)2.02077607
122Opisthotonus (HP:0002179)2.00341830
123Hemorrhage of the eye (HP:0011885)1.99579344
124Late onset (HP:0003584)1.99564819
125Gangrene (HP:0100758)1.99446073
126Rickets (HP:0002748)1.98744451
127Abnormality of transition element cation homeostasis (HP:0011030)1.98195799
128Chronic obstructive pulmonary disease (HP:0006510)1.95859718
129Obstructive lung disease (HP:0006536)1.95859718
130Acne (HP:0001061)1.94733294
131Abnormal enzyme/coenzyme activity (HP:0012379)1.94036745
132Pulmonary infiltrates (HP:0002113)1.92923696
133Increased serum ferritin (HP:0003281)1.92681956
134Abnormality of the gallbladder (HP:0005264)1.90885589
135Abnormal platelet volume (HP:0011876)1.90782325
136Joint swelling (HP:0001386)1.90155457
137Aneurysm (HP:0002617)1.89608264
138Cerebral aneurysm (HP:0004944)1.89551696
139Recurrent fungal infections (HP:0002841)1.89367068
140Hypertriglyceridemia (HP:0002155)1.89208744
141Cellulitis (HP:0100658)1.87116102
142Episodic fever (HP:0001954)1.86859965
143Anorexia (HP:0002039)1.86071202
144Status epilepticus (HP:0002133)1.86061429
145Poikilocytosis (HP:0004447)1.83565998
146Elevated hepatic transaminases (HP:0002910)1.82167204
147Renal cortical cysts (HP:0000803)1.81930231
148Dilatation of the ascending aorta (HP:0005111)1.80818165
149Abnormality of proline metabolism (HP:0010907)1.76760398
150Hydroxyprolinuria (HP:0003080)1.76760398
151Abnormal delayed hypersensitivity skin test (HP:0002963)1.76453172
152Elevated alkaline phosphatase (HP:0003155)1.75710497
153Interstitial pulmonary disease (HP:0006530)1.75523597
154Dysostosis multiplex (HP:0000943)1.75190950
155Upper motor neuron abnormality (HP:0002127)1.75145567
156Polygenic inheritance (HP:0010982)1.74305565
157Nephritis (HP:0000123)1.73444684
158Hyperuricemia (HP:0002149)1.73315751
159Increased purine levels (HP:0004368)1.73315751
160Impaired platelet aggregation (HP:0003540)1.72964200
161Abnormal platelet function (HP:0011869)1.72964200
162Mediastinal lymphadenopathy (HP:0100721)1.72208721
163Vertebral compression fractures (HP:0002953)1.71835097

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.72192151
2ERN16.04012044
3SIK13.99509277
4FGFR43.85975939
5TAOK32.90040796
6INSRR2.56865940
7RIPK42.33804543
8ERBB42.30567311
9GRK62.22108709
10MAP4K12.14023362
11MAP2K42.13001860
12PRPF4B1.84015377
13FLT31.79889419
14PKN21.79111572
15TGFBR21.78899824
16TNK21.70050540
17IRAK41.67917720
18MST1R1.67220560
19CDK121.67185051
20PIK3CG1.65563639
21GRK11.64523805
22MAPK111.57452888
23CSF1R1.56260405
24TYK21.55011883
25TRIB31.49860071
26FES1.49393337
27MAP3K61.47675016
28JAK31.47506611
29ABL21.35421337
30PRKD21.34097909
31MAP3K11.32200330
32LATS11.30758795
33GRK51.30343434
34CDC42BPA1.25081075
35NEK91.23588551
36MAPK71.23295746
37MARK21.18685666
38MAP3K71.17397265
39MAP3K101.16287768
40SMG11.15102468
41IRAK31.12808280
42PTK61.12335871
43HCK1.11482621
44JAK21.10543102
45MAP3K21.09758298
46ADRBK21.09109347
47MAP2K31.06821876
48KDR1.06125506
49MAP3K141.01177258
50TBK11.00705274
51ICK1.00658758
52PRKAA20.99198028
53CSK0.99096150
54TIE10.98020060
55MAPK40.97533975
56NLK0.96839617
57PDGFRA0.96771192
58TAOK10.96688018
59FRK0.95630171
60MAP2K60.95444595
61ERBB20.92426200
62MAPK120.90921942
63FGR0.88765906
64SYK0.86926850
65STK380.85187160
66JAK10.85136050
67PINK10.83003889
68HIPK20.82854727
69FGFR30.82445011
70KSR20.80843459
71RET0.79893810
72EPHB10.79640651
73DAPK20.79216904
74MAP3K30.79075299
75PDGFRB0.78851452
76MYLK0.77465219
77LYN0.77024280
78CAMK1D0.76876716
79BLK0.74068191
80EPHA30.73661454
81PTK2B0.72272069
82CAMK40.71543041
83LCK0.70277239
84LRRK20.68659933
85MATK0.67344681
86PRKACG0.66948902
87GRK70.65939811
88PRKCZ0.65362752
89DYRK1B0.64748974
90FGFR20.64147048
91WNK10.63672392
92YES10.63025643
93CDK60.62722486
94STK38L0.59593047
95DDR20.59342952
96MAPK150.59022586
97GSK3A0.56487361
98RIPK10.55603278
99FER0.55398344
100IKBKE0.54572803
101IGF1R0.54416024
102EEF2K0.54199742
103RPS6KL10.54164747
104RPS6KC10.54164747
105MET0.53499145
106PRKAA10.53190008
107PRKG20.52214386
108PTK20.50004264
109MAP3K110.49188605
110RPS6KA20.48333664
111TAOK20.46867768
112AKT30.46178920
113KIT0.46017082
114TRPM70.45666259
115FYN0.44094260
116TTN0.44073743
117RPS6KA60.43853699
118PIK3CA0.42981856
119MOS0.42433211
120CDK40.42270574
121MARK30.41997359
122IRAK10.40053840
123IKBKB0.39875757
124SIK30.39589240
125PRKD10.38572513
126PRKCQ0.37718570
127STK100.37233913
128MTOR0.36805599
129CAMK2G0.36619712
130MAPKAPK20.36508534
131ZAP700.35321157
132MAP2K20.33095798
133IRAK20.30111458
134SGK30.29889462
135ABL10.28983564
136PDPK10.28868416
137MAP2K10.28731996
138EGFR0.28419151
139ITK0.26247445
140CHUK0.25751250
141MAP3K50.24748242
142PRKCD0.24733287
143PDK10.24335932
144MAP3K130.23269675
145MAPK30.23216850
146BTK0.22006459
147ADRBK10.20842807
148BMX0.20519511

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.53497597
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.34715985
3Nitrogen metabolism_Homo sapiens_hsa009103.31753464
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.17958327
5Arginine biosynthesis_Homo sapiens_hsa002202.93794068
6Complement and coagulation cascades_Homo sapiens_hsa046102.85419009
7Tryptophan metabolism_Homo sapiens_hsa003802.71931198
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.61244046
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.57979141
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55195481
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.47314421
12Fatty acid degradation_Homo sapiens_hsa000712.45249896
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.42833450
14Peroxisome_Homo sapiens_hsa041462.11456140
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10712157
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.05674879
17Butanoate metabolism_Homo sapiens_hsa006502.04513609
18Chemical carcinogenesis_Homo sapiens_hsa052042.01047406
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.93245546
20Propanoate metabolism_Homo sapiens_hsa006401.90074246
21Histidine metabolism_Homo sapiens_hsa003401.89494748
22PPAR signaling pathway_Homo sapiens_hsa033201.86267530
23Staphylococcus aureus infection_Homo sapiens_hsa051501.85425424
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.78124376
25Fatty acid metabolism_Homo sapiens_hsa012121.74728396
26Retinol metabolism_Homo sapiens_hsa008301.73480003
27beta-Alanine metabolism_Homo sapiens_hsa004101.71759386
28Caffeine metabolism_Homo sapiens_hsa002321.70237402
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66639709
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.65428782
31Selenocompound metabolism_Homo sapiens_hsa004501.58068552
32Phenylalanine metabolism_Homo sapiens_hsa003601.49585028
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49028195
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48073326
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44833704
36Bile secretion_Homo sapiens_hsa049761.43697299
37Tyrosine metabolism_Homo sapiens_hsa003501.40827386
38Folate biosynthesis_Homo sapiens_hsa007901.38599183
39Leishmaniasis_Homo sapiens_hsa051401.36322387
40Osteoclast differentiation_Homo sapiens_hsa043801.34371026
41Starch and sucrose metabolism_Homo sapiens_hsa005001.33840656
42Sulfur metabolism_Homo sapiens_hsa009201.31850256
43Vitamin B6 metabolism_Homo sapiens_hsa007501.31036305
44Pyruvate metabolism_Homo sapiens_hsa006201.29691135
45Fatty acid elongation_Homo sapiens_hsa000621.28115599
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.27405968
47ABC transporters_Homo sapiens_hsa020101.20813166
48Fat digestion and absorption_Homo sapiens_hsa049751.19552445
49Steroid biosynthesis_Homo sapiens_hsa001001.16404744
50Biosynthesis of amino acids_Homo sapiens_hsa012301.16188072
51Malaria_Homo sapiens_hsa051441.15789457
52Carbon metabolism_Homo sapiens_hsa012001.10470604
53Sulfur relay system_Homo sapiens_hsa041221.07481897
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.02550991
55Cyanoamino acid metabolism_Homo sapiens_hsa004601.00965257
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99312317
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98990413
58Arginine and proline metabolism_Homo sapiens_hsa003300.93620125
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93603911
60Vitamin digestion and absorption_Homo sapiens_hsa049770.90384772
61Amoebiasis_Homo sapiens_hsa051460.86538220
62One carbon pool by folate_Homo sapiens_hsa006700.82810587
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82518449
64Acute myeloid leukemia_Homo sapiens_hsa052210.79322561
65Lysine degradation_Homo sapiens_hsa003100.79139477
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78996200
67Tuberculosis_Homo sapiens_hsa051520.78337815
68Graft-versus-host disease_Homo sapiens_hsa053320.75451114
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74509606
70B cell receptor signaling pathway_Homo sapiens_hsa046620.74114866
71Glycerolipid metabolism_Homo sapiens_hsa005610.72892272
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71761039
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71523183
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70945289
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70389644
76Toxoplasmosis_Homo sapiens_hsa051450.68402542
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.68103691
78Glutathione metabolism_Homo sapiens_hsa004800.66274084
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.65984304
80Pentose phosphate pathway_Homo sapiens_hsa000300.63149297
81Platelet activation_Homo sapiens_hsa046110.62353520
82Hematopoietic cell lineage_Homo sapiens_hsa046400.61291649
83TNF signaling pathway_Homo sapiens_hsa046680.58650875
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58625442
85Allograft rejection_Homo sapiens_hsa053300.56443192
86Influenza A_Homo sapiens_hsa051640.55848619
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54228928
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.53721319
89Chemokine signaling pathway_Homo sapiens_hsa040620.52913873
90Measles_Homo sapiens_hsa051620.52909230
91Autoimmune thyroid disease_Homo sapiens_hsa053200.51867887
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50995767
93Phagosome_Homo sapiens_hsa041450.49221177
94Metabolic pathways_Homo sapiens_hsa011000.48608904
95Fructose and mannose metabolism_Homo sapiens_hsa000510.48545956
96Fatty acid biosynthesis_Homo sapiens_hsa000610.46635799
97ECM-receptor interaction_Homo sapiens_hsa045120.45651290
98Galactose metabolism_Homo sapiens_hsa000520.45067588
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43728342
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42668903
101Non-small cell lung cancer_Homo sapiens_hsa052230.41885526
102Notch signaling pathway_Homo sapiens_hsa043300.41462237
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41068343
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40778319
105Chronic myeloid leukemia_Homo sapiens_hsa052200.39228043
106Pancreatic cancer_Homo sapiens_hsa052120.37073861
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36470988
108Linoleic acid metabolism_Homo sapiens_hsa005910.36147432
109Focal adhesion_Homo sapiens_hsa045100.35872879
110Prion diseases_Homo sapiens_hsa050200.35767500
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35263364
112Prolactin signaling pathway_Homo sapiens_hsa049170.34502440
113Choline metabolism in cancer_Homo sapiens_hsa052310.32090171
114VEGF signaling pathway_Homo sapiens_hsa043700.31738042
115Herpes simplex infection_Homo sapiens_hsa051680.28290103
116T cell receptor signaling pathway_Homo sapiens_hsa046600.27340967
117FoxO signaling pathway_Homo sapiens_hsa040680.27066254
118Insulin resistance_Homo sapiens_hsa049310.22397414
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.22372865
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.17902474
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.09944329
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08219758
123Arachidonic acid metabolism_Homo sapiens_hsa005900.07962335
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.02137786
125AMPK signaling pathway_Homo sapiens_hsa041520.01259626
126Glucagon signaling pathway_Homo sapiens_hsa049220.00500788
127Lysosome_Homo sapiens_hsa04142-0.2228841
128Protein digestion and absorption_Homo sapiens_hsa04974-0.2198397
129Pertussis_Homo sapiens_hsa05133-0.2082876
130Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1812572
131Ether lipid metabolism_Homo sapiens_hsa00565-0.1784200
132Other glycan degradation_Homo sapiens_hsa00511-0.1756496
133Insulin signaling pathway_Homo sapiens_hsa04910-0.1589359
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1519857
135Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1475294
136Renin-angiotensin system_Homo sapiens_hsa04614-0.1392840
137Hepatitis C_Homo sapiens_hsa05160-0.1362660
138RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1105860
139African trypanosomiasis_Homo sapiens_hsa05143-0.0861158
140Regulation of autophagy_Homo sapiens_hsa04140-0.0765881
141Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0723013
142Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0515974
143Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0462540
144Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0005326

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