C1QTNF9B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of oxidative phosphorylation (GO:0002082)5.11908737
2ribosomal small subunit biogenesis (GO:0042274)4.95894628
3chaperone-mediated protein transport (GO:0072321)4.73144273
4cellular response to zinc ion (GO:0071294)4.71357498
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.71075373
6rRNA modification (GO:0000154)4.53140500
7rRNA methylation (GO:0031167)4.40103063
8negative regulation of hydrogen peroxide-induced cell death (GO:1903206)4.36851302
9regulation of cellular respiration (GO:0043457)4.29202162
10ribosomal large subunit biogenesis (GO:0042273)4.27327689
11AMP metabolic process (GO:0046033)4.17478326
12ribosome assembly (GO:0042255)4.14589972
13negative regulation of response to reactive oxygen species (GO:1901032)3.93844376
14ATP synthesis coupled proton transport (GO:0015986)3.90681080
15energy coupled proton transport, down electrochemical gradient (GO:0015985)3.90681080
16nucleobase-containing small molecule interconversion (GO:0015949)3.81681557
17proteasome assembly (GO:0043248)3.78831229
18protein targeting to ER (GO:0045047)3.77889181
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.76105670
20protein localization to endoplasmic reticulum (GO:0070972)3.72233132
21cotranslational protein targeting to membrane (GO:0006613)3.71078163
22regulation of hydrogen peroxide-induced cell death (GO:1903205)3.69977876
23ADP metabolic process (GO:0046031)3.68500443
24viral transcription (GO:0019083)3.66277744
25protein targeting to mitochondrion (GO:0006626)3.65766247
26positive regulation of catecholamine secretion (GO:0033605)3.63965539
27establishment of protein localization to endoplasmic reticulum (GO:0072599)3.63176493
28translational termination (GO:0006415)3.54053609
29translation (GO:0006412)3.51964695
30cullin deneddylation (GO:0010388)3.51905083
31mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.48148192
32DNA double-strand break processing (GO:0000729)3.47892952
33ribonucleoprotein complex biogenesis (GO:0022613)3.43959422
34protein maturation by protein folding (GO:0022417)3.41025342
35glutathione derivative biosynthetic process (GO:1901687)3.38291373
36glutathione derivative metabolic process (GO:1901685)3.38291373
37respiratory electron transport chain (GO:0022904)3.34975162
38translational elongation (GO:0006414)3.34257469
39binding of sperm to zona pellucida (GO:0007339)3.33038815
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.32598452
41pteridine-containing compound biosynthetic process (GO:0042559)3.30875789
42electron transport chain (GO:0022900)3.29054589
43sperm motility (GO:0030317)3.26336832
44protein deneddylation (GO:0000338)3.23852396
45ribosomal small subunit assembly (GO:0000028)3.23766940
46regulation of cellular amino acid metabolic process (GO:0006521)3.21985609
47activation of protein kinase B activity (GO:0032148)3.21109929
48histone exchange (GO:0043486)3.20936441
49regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.19734154
50negative regulation of ligase activity (GO:0051352)3.15749238
51negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.15749238
52positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.15285635
53positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.14051692
54cellular component biogenesis (GO:0044085)3.11958576
55establishment of protein localization to mitochondrion (GO:0072655)3.09284264
56protein localization to mitochondrion (GO:0070585)3.09225929
57CENP-A containing nucleosome assembly (GO:0034080)3.07308342
58guanosine-containing compound biosynthetic process (GO:1901070)3.05813332
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.04306426
60GTP biosynthetic process (GO:0006183)3.03597568
61regulation of oxidative stress-induced neuron death (GO:1903203)3.03515930
62translational initiation (GO:0006413)3.03047159
63positive regulation of ligase activity (GO:0051351)3.02530376
64peptidyl-histidine modification (GO:0018202)3.00867633
65viral life cycle (GO:0019058)2.98402929
66deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.97995320
67IMP metabolic process (GO:0046040)2.97578555
68erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.96831967
69L-phenylalanine metabolic process (GO:0006558)2.96831967
70chromatin remodeling at centromere (GO:0031055)2.96797410
71coenzyme catabolic process (GO:0009109)2.91651817
72establishment of protein localization to mitochondrial membrane (GO:0090151)2.91249624
73regulation of ubiquitin-protein transferase activity (GO:0051438)2.90726720
74spliceosomal snRNP assembly (GO:0000387)2.90062918
75protein complex biogenesis (GO:0070271)2.89559000
76erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.88636257
77L-phenylalanine catabolic process (GO:0006559)2.88636257
78single fertilization (GO:0007338)2.87352720
79mitochondrial respiratory chain complex assembly (GO:0033108)2.85183146
80nucleoside salvage (GO:0043174)2.84251206
81regulation of ligase activity (GO:0051340)2.82018170
82nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.81574591
83nucleoside diphosphate phosphorylation (GO:0006165)2.80244707
84respiratory chain complex IV assembly (GO:0008535)2.79730740
85regulation of autophagic vacuole assembly (GO:2000785)2.76763457
86rRNA processing (GO:0006364)2.75372630
87cellular protein complex disassembly (GO:0043624)2.75166861
88purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.74983742
89purine nucleoside monophosphate biosynthetic process (GO:0009127)2.74983742
90peroxisome fission (GO:0016559)2.74740674
91DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.73876221
92IMP biosynthetic process (GO:0006188)2.70282182
93L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.69825349
94UTP biosynthetic process (GO:0006228)2.69091367
95signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.69014587
96signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.69014587
97signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.69014587
98oxidative phosphorylation (GO:0006119)2.68970465
99mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.67850934
100NADH dehydrogenase complex assembly (GO:0010257)2.67850934

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.87113113
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.18812816
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.01147579
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.47434917
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.04979901
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.85335172
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.69522200
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.41167325
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.23701448
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.97557681
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.78569078
12DCP1A_22483619_ChIP-Seq_HELA_Human2.77704008
13AR_21909140_ChIP-Seq_LNCAP_Human2.66827039
14SRF_21415370_ChIP-Seq_HL-1_Mouse2.65657709
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.63195149
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.54973251
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.44351825
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.31931750
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.28045544
20E2F1_18555785_ChIP-Seq_MESCs_Mouse2.25669961
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.19279106
22FOXP3_21729870_ChIP-Seq_TREG_Human2.18905496
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.16695295
24ELK1_19687146_ChIP-ChIP_HELA_Human2.12395720
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07370142
26VDR_23849224_ChIP-Seq_CD4+_Human2.05274449
27XRN2_22483619_ChIP-Seq_HELA_Human2.05141832
28GABP_19822575_ChIP-Seq_HepG2_Human1.97174678
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88100139
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.86523980
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.82577742
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81598460
33TTF2_22483619_ChIP-Seq_HELA_Human1.81465702
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.81006522
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80479632
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74723849
37E2F7_22180533_ChIP-Seq_HELA_Human1.70390684
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68958930
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.56776230
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53423930
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49794921
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.41590259
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40189967
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39325946
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38365983
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37464642
47ELF5_23300383_ChIP-Seq_T47D_Human1.35509940
48BP1_19119308_ChIP-ChIP_Hs578T_Human1.34132233
49ELK1_22589737_ChIP-Seq_MCF10A_Human1.32869463
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32543236
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32190294
52BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.32037421
53E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.29242505
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28161577
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.24280331
56SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20776430
57CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14614444
58TFEB_21752829_ChIP-Seq_HELA_Human1.14475458
59ESR1_20079471_ChIP-ChIP_T-47D_Human1.14137397
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.13686163
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12474074
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.11306097
63KDM5A_27292631_Chip-Seq_BREAST_Human1.09441527
64HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08952904
65ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07214125
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07042013
67CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.06901030
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06715574
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06519658
70PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.05776909
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03276091
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02558756
73ZNF263_19887448_ChIP-Seq_K562_Human1.01839592
74SOX17_20123909_ChIP-Seq_XEN_Mouse1.01169531
75MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.99425909
76ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99352874
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98499697
78MYC_18940864_ChIP-ChIP_HL60_Human0.97597846
79TBX5_21415370_ChIP-Seq_HL-1_Mouse0.94498116
80FUS_26573619_Chip-Seq_HEK293_Human0.93576704
81ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.93168637
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87822973
83FOXM1_23109430_ChIP-Seq_U2OS_Human0.87111609
84CHD1_26751641_Chip-Seq_LNCaP_Human0.83456624
85E2F1_21310950_ChIP-Seq_MCF-7_Human0.82868547
86ERG_20517297_ChIP-Seq_VCAP_Human0.79967526
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.79881071
88CTCF_18555785_ChIP-Seq_MESCs_Mouse0.79613880
89SOX2_18555785_ChIP-Seq_MESCs_Mouse0.78022909
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.75585401
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.74123730
92NANOG_18555785_ChIP-Seq_MESCs_Mouse0.73833119
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.72683373
94CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.72274598
95CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.72152899
96TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.71201408
97PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.71062709
98GATA4_21415370_ChIP-Seq_HL-1_Mouse0.70531181
99ERA_21632823_ChIP-Seq_H3396_Human0.67706744
100FOXP1_21924763_ChIP-Seq_HESCs_Human0.67428953

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis6.70941041
2MP0005410_abnormal_fertilization3.56491748
3MP0006036_abnormal_mitochondrial_physio3.40800756
4MP0000749_muscle_degeneration3.19093644
5MP0009697_abnormal_copulation2.91271286
6MP0003315_abnormal_perineum_morphology2.74071451
7MP0002132_abnormal_respiratory_system2.68496216
8MP0002837_dystrophic_cardiac_calcinosis2.62530356
9MP0003718_maternal_effect2.55671239
10MP0010234_abnormal_vibrissa_follicle2.33959382
11MP0003186_abnormal_redox_activity2.31237262
12MP0002160_abnormal_reproductive_system2.29435176
13MP0004957_abnormal_blastocyst_morpholog2.29064417
14MP0006072_abnormal_retinal_apoptosis2.20136332
15MP0008058_abnormal_DNA_repair2.11054455
16MP0003693_abnormal_embryo_hatching2.10240546
17MP0005058_abnormal_lysosome_morphology2.08298150
18MP0000372_irregular_coat_pigmentation2.03397608
19MP0003077_abnormal_cell_cycle2.00142414
20MP0010094_abnormal_chromosome_stability1.98294652
21MP0010386_abnormal_urinary_bladder1.93307275
22MP0009780_abnormal_chondrocyte_physiolo1.88652991
23MP0005330_cardiomyopathy1.87041805
24MP0008007_abnormal_cellular_replicative1.82516644
25MP0002090_abnormal_vision1.78219209
26MP0008932_abnormal_embryonic_tissue1.63456237
27MP0003950_abnormal_plasma_membrane1.58378104
28MP0002108_abnormal_muscle_morphology1.54646386
29MP0003786_premature_aging1.53645901
30MP0002295_abnormal_pulmonary_circulatio1.43351379
31MP0001929_abnormal_gametogenesis1.40585807
32MP0003136_yellow_coat_color1.37787305
33MP0008004_abnormal_stomach_pH1.35082476
34MP0000538_abnormal_urinary_bladder1.34055309
35MP0003111_abnormal_nucleus_morphology1.33952653
36MP0010368_abnormal_lymphatic_system1.32989267
37MP0004272_abnormal_basement_membrane1.31225251
38MP0001849_ear_inflammation1.30935370
39MP0002877_abnormal_melanocyte_morpholog1.24677693
40MP0000678_abnormal_parathyroid_gland1.24201590
41MP0005187_abnormal_penis_morphology1.23507947
42MP0001905_abnormal_dopamine_level1.23324960
43MP0003698_abnormal_male_reproductive1.23050015
44MP0005408_hypopigmentation1.22313326
45MP0005266_abnormal_metabolism1.18862302
46MP0003705_abnormal_hypodermis_morpholog1.17971392
47MP0005395_other_phenotype1.17503366
48MP0009250_abnormal_appendicular_skeleto1.17272918
49MP0000762_abnormal_tongue_morphology1.17032918
50MP0005332_abnormal_amino_acid1.16211606
51MP0004215_abnormal_myocardial_fiber1.13678531
52MP0004084_abnormal_cardiac_muscle1.13288646
53MP0008438_abnormal_cutaneous_collagen1.12990956
54MP0008789_abnormal_olfactory_epithelium1.09116470
55MP0000759_abnormal_skeletal_muscle1.08946969
56MP0001764_abnormal_homeostasis1.08493866
57MP0000343_altered_response_to1.07883558
58MP0000537_abnormal_urethra_morphology1.06611841
59MP0002210_abnormal_sex_determination1.04440902
60MP0004036_abnormal_muscle_relaxation1.03424987
61MP0005389_reproductive_system_phenotype1.01365231
62MP0005503_abnormal_tendon_morphology0.98289254
63MP0001664_abnormal_digestion0.97531175
64MP0000653_abnormal_sex_gland0.95115604
65MP0010030_abnormal_orbit_morphology0.94820493
66MP0000750_abnormal_muscle_regeneration0.94695692
67MP0001145_abnormal_male_reproductive0.94058346
68MP0002269_muscular_atrophy0.93767030
69MP0000733_abnormal_muscle_development0.92228678
70MP0005360_urolithiasis0.91669008
71MP0001730_embryonic_growth_arrest0.89189492
72MP0002163_abnormal_gland_morphology0.88806349
73MP0002938_white_spotting0.87010090
74MP0005257_abnormal_intraocular_pressure0.86486941
75MP0003385_abnormal_body_wall0.86287210
76MP0005379_endocrine/exocrine_gland_phen0.85353965
77MP0005253_abnormal_eye_physiology0.83364194
78MP0000747_muscle_weakness0.83170890
79MP0001661_extended_life_span0.82329314
80MP0001756_abnormal_urination0.82137385
81MP0001881_abnormal_mammary_gland0.81910793
82MP0001529_abnormal_vocalization0.81606375
83MP0004087_abnormal_muscle_fiber0.80336300
84MP0002127_abnormal_cardiovascular_syste0.79791093
85MP0005620_abnormal_muscle_contractility0.78653479
86MP0004233_abnormal_muscle_weight0.73411127
87MP0008057_abnormal_DNA_replication0.71515039
88MP0000613_abnormal_salivary_gland0.71069455
89MP0001188_hyperpigmentation0.70016886
90MP0002161_abnormal_fertility/fecundity0.69911760
91MP0005275_abnormal_skin_tensile0.68851078
92MP0005647_abnormal_sex_gland0.68491286
93MP0002796_impaired_skin_barrier0.68205682
94MP0002233_abnormal_nose_morphology0.67711468
95MP0005220_abnormal_exocrine_pancreas0.67032484
96MP0005165_increased_susceptibility_to0.67016640
97MP0003936_abnormal_reproductive_system0.66349941
98MP0001853_heart_inflammation0.65465263
99MP0000358_abnormal_cell_content/0.64342783
100MP0002080_prenatal_lethality0.62025567

Predicted human phenotypes

RankGene SetZ-score
1Renal Fanconi syndrome (HP:0001994)4.97079547
2Reduced antithrombin III activity (HP:0001976)4.47981762
3Resting tremor (HP:0002322)4.32111176
4Decreased activity of mitochondrial respiratory chain (HP:0008972)4.25469782
5Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.25469782
6Lipid accumulation in hepatocytes (HP:0006561)4.06149421
7Abnormality of aromatic amino acid family metabolism (HP:0004338)4.00460602
8Mitochondrial inheritance (HP:0001427)3.65541633
9Increased hepatocellular lipid droplets (HP:0006565)3.64316141
10Acute necrotizing encephalopathy (HP:0006965)3.55407071
11Increased CSF lactate (HP:0002490)3.29243164
12Sensory axonal neuropathy (HP:0003390)3.27727068
13Acute encephalopathy (HP:0006846)3.16100423
14Abnormal mitochondria in muscle tissue (HP:0008316)3.13687903
15Hepatocellular necrosis (HP:0001404)3.12078903
16Macrocytic anemia (HP:0001972)2.97419642
17Progressive macrocephaly (HP:0004481)2.94434732
18Abnormal glycosylation (HP:0012345)2.94063800
19Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.94063800
20Abnormal protein N-linked glycosylation (HP:0012347)2.94063800
21Abnormal protein glycosylation (HP:0012346)2.94063800
22Abnormality of renal resorption (HP:0011038)2.92132162
23Hepatic necrosis (HP:0002605)2.92012269
24Type I transferrin isoform profile (HP:0003642)2.90086687
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.72417982
26Rhabdomyolysis (HP:0003201)2.69479829
27Aplasia/hypoplasia of the uterus (HP:0008684)2.68290529
28Abnormality of the intrinsic pathway (HP:0010989)2.66674584
29Increased muscle lipid content (HP:0009058)2.63421779
30Aplastic anemia (HP:0001915)2.56016563
31Hypoplasia of the uterus (HP:0000013)2.55760617
32Abnormality of methionine metabolism (HP:0010901)2.55480189
33Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.55357154
34Lactic acidosis (HP:0003128)2.48934012
35Respiratory failure (HP:0002878)2.44632346
36Increased intramyocellular lipid droplets (HP:0012240)2.42590294
37Exertional dyspnea (HP:0002875)2.39929270
38Conjunctival hamartoma (HP:0100780)2.38947083
39Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.38882369
40Cerebral edema (HP:0002181)2.38630959
41Abnormality of cells of the erythroid lineage (HP:0012130)2.36680733
42Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.35317514
43Increased serum lactate (HP:0002151)2.35218514
44Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.32327135
45Abnormality of placental membranes (HP:0011409)2.31974509
46Amniotic constriction ring (HP:0009775)2.31974509
47Exercise intolerance (HP:0003546)2.31399979
48Hypophosphatemic rickets (HP:0004912)2.27712379
49Sex reversal (HP:0012245)2.25901849
50Abnormal sex determination (HP:0012244)2.25901849
51Generalized aminoaciduria (HP:0002909)2.25547454
52Abnormality of the frontal sinuses (HP:0002687)2.22857195
533-Methylglutaconic aciduria (HP:0003535)2.22396424
54Cerebral hypomyelination (HP:0006808)2.20038184
55Exercise-induced muscle cramps (HP:0003710)2.18382279
56Abnormal respiratory motile cilium physiology (HP:0012261)2.17329796
57Abnormal number of erythroid precursors (HP:0012131)2.16489679
58Respiratory difficulties (HP:0002880)2.15509071
59Aplasia/Hypoplasia of the sacrum (HP:0008517)2.15012936
60Abnormality of the shoulder girdle musculature (HP:0001435)2.13958545
61Spinal rigidity (HP:0003306)2.13331873
62Centrally nucleated skeletal muscle fibers (HP:0003687)2.10915575
63Generalized amyotrophy (HP:0003700)2.03830567
64CNS demyelination (HP:0007305)2.03124289
65Abnormality of the ileum (HP:0001549)2.01226342
66Abnormality of the preputium (HP:0100587)1.99775679
67Meckel diverticulum (HP:0002245)1.98419820
68Abnormal umbilical cord blood vessels (HP:0011403)1.98265414
69Single umbilical artery (HP:0001195)1.98265414
70Abnormality of the fetal cardiovascular system (HP:0010948)1.98265414
71Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.97756918
72Male pseudohermaphroditism (HP:0000037)1.97585094
73Absent thumb (HP:0009777)1.95799710
74Ileus (HP:0002595)1.95434401
75Degeneration of anterior horn cells (HP:0002398)1.93371061
76Abnormality of the anterior horn cell (HP:0006802)1.93371061
77Sparse eyelashes (HP:0000653)1.93120305
78Myoglobinuria (HP:0002913)1.92214633
79Right ventricular cardiomyopathy (HP:0011663)1.91191509
80Abnormality of abdominal situs (HP:0011620)1.89725940
81Abdominal situs inversus (HP:0003363)1.89725940
82Congenital ichthyosiform erythroderma (HP:0007431)1.87074882
83Abnormality of the umbilical cord (HP:0010881)1.86416171
84Hyperammonemia (HP:0001987)1.85417385
85Hypergonadotropic hypogonadism (HP:0000815)1.84742560
86Abnormalities of placenta or umbilical cord (HP:0001194)1.82896095
87Abnormal spermatogenesis (HP:0008669)1.82624754
88Scapular winging (HP:0003691)1.81897339
89Poor head control (HP:0002421)1.81643587
90Pancreatic islet-cell hyperplasia (HP:0004510)1.80100932
91Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79097160
92Rhinitis (HP:0012384)1.78693193
93Abnormal ciliary motility (HP:0012262)1.78528173
94Paralysis (HP:0003470)1.77977561
95Aplasia/Hypoplasia of the uvula (HP:0010293)1.75033975
96Testicular atrophy (HP:0000029)1.74965272
97Methylmalonic aciduria (HP:0012120)1.74641435
98Dicarboxylic aciduria (HP:0003215)1.74547394
99Abnormality of dicarboxylic acid metabolism (HP:0010995)1.74547394
100Oral leukoplakia (HP:0002745)1.73114922

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK15.30083991
2NME23.60401586
3STK163.55686125
4EIF2AK33.46670657
5MYLK3.25009245
6EIF2AK13.13968976
7VRK23.07465765
8BUB12.89669092
9MARK32.73137298
10ZAK2.68918155
11PBK2.35863930
12MST42.19335356
13ARAF2.07404398
14SRPK12.05857152
15NME11.87548911
16OBSCN1.77488779
17CDK191.76659355
18BMPR1B1.73336836
19PLK41.70222880
20NEK11.69096420
21VRK11.54931620
22TESK11.51594908
23TLK11.42526549
24LIMK11.41034872
25RPS6KB21.32581047
26PAK41.32190872
27AKT31.26963060
28ILK1.21832532
29PHKG21.17957875
30PHKG11.17957875
31MUSK1.17657980
32CSNK1G31.15096066
33CDC71.15072310
34MOS1.14629456
35TTK1.13883193
36CSNK1A1L1.13502787
37PRKG21.05780061
38NEK21.02934068
39BRAF1.02476957
40PLK31.00772494
41INSRR0.99775651
42PAK20.97115980
43CDK80.96499468
44BCKDK0.92802233
45MAP3K120.92532726
46GRK10.91471941
47CSNK1G10.89832780
48PKN20.88448967
49CDK30.87706567
50OXSR10.86232013
51STK38L0.86230085
52BRSK20.86058980
53AURKB0.81191515
54PAK10.81146456
55TIE10.80666868
56WEE10.79005066
57NUAK10.77945230
58MST1R0.75224250
59LATS20.74868771
60LATS10.74016787
61AURKA0.73646096
62AKT20.73306049
63PLK10.72645035
64MAP3K130.72372385
65MAP3K90.72259158
66TGFBR10.69021208
67RPS6KA50.64689168
68MAP4K20.63526107
69ABL20.60904314
70MAPKAPK30.59828271
71CSNK1G20.56537623
72CDK90.55003842
73CDK70.54428478
74DAPK30.52769460
75STK380.47032731
76PLK20.46592057
77EEF2K0.46026835
78CCNB10.45301189
79RPS6KB10.44900657
80ADRBK20.41542359
81WNK40.40651102
82CDK140.40007187
83TAF10.36882353
84PDK20.35433807
85EIF2AK20.35346378
86CHEK20.33913882
87CSNK2A20.32801904
88SMG10.30882450
89IRAK30.30205652
90ATR0.29821565
91CAMK2D0.29784554
92CLK10.29781529
93STK40.29603844
94CSNK2A10.27779726
95PIM20.27708896
96ATM0.27518566
97GRK50.27057503
98FRK0.26709451
99TRIB30.24485857
100BRSK10.24310134

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.20253434
2Proteasome_Homo sapiens_hsa030503.82877515
3Oxidative phosphorylation_Homo sapiens_hsa001903.27647613
4Protein export_Homo sapiens_hsa030603.05963547
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.02346659
6Parkinsons disease_Homo sapiens_hsa050122.77592863
7DNA replication_Homo sapiens_hsa030302.39394065
8Glutathione metabolism_Homo sapiens_hsa004802.21258205
9Folate biosynthesis_Homo sapiens_hsa007902.17347226
10Nucleotide excision repair_Homo sapiens_hsa034202.02539679
11Mismatch repair_Homo sapiens_hsa034301.96382584
12RNA polymerase_Homo sapiens_hsa030201.96318850
13Huntingtons disease_Homo sapiens_hsa050161.96307944
14Alzheimers disease_Homo sapiens_hsa050101.85036511
15Pyruvate metabolism_Homo sapiens_hsa006201.78519244
16Propanoate metabolism_Homo sapiens_hsa006401.76314892
17Pyrimidine metabolism_Homo sapiens_hsa002401.72759681
18One carbon pool by folate_Homo sapiens_hsa006701.66890059
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66745047
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.66395207
21Basal transcription factors_Homo sapiens_hsa030221.60425450
22Homologous recombination_Homo sapiens_hsa034401.59125429
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56715397
24RNA transport_Homo sapiens_hsa030131.55094892
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.45566499
26Fatty acid elongation_Homo sapiens_hsa000621.40657058
27Base excision repair_Homo sapiens_hsa034101.39828046
28Pentose phosphate pathway_Homo sapiens_hsa000301.37938911
29Purine metabolism_Homo sapiens_hsa002301.36569742
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.34798193
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34066179
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.30778027
33Carbon metabolism_Homo sapiens_hsa012001.26565712
34RNA degradation_Homo sapiens_hsa030181.26193222
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.23005141
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18842640
37Chemical carcinogenesis_Homo sapiens_hsa052041.14675839
38Arginine biosynthesis_Homo sapiens_hsa002201.14004477
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.12597036
40Fatty acid degradation_Homo sapiens_hsa000711.11580098
41Biosynthesis of amino acids_Homo sapiens_hsa012301.10639505
42Tyrosine metabolism_Homo sapiens_hsa003501.10370631
43Fanconi anemia pathway_Homo sapiens_hsa034601.09131446
44Collecting duct acid secretion_Homo sapiens_hsa049661.07977251
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07957629
46Non-homologous end-joining_Homo sapiens_hsa034501.07348377
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06461152
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04622432
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03886688
50Spliceosome_Homo sapiens_hsa030401.02478945
51Nitrogen metabolism_Homo sapiens_hsa009101.01952848
52Sulfur relay system_Homo sapiens_hsa041220.97844138
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.96624864
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96143192
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95125254
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94080660
57Butanoate metabolism_Homo sapiens_hsa006500.92542417
58Cardiac muscle contraction_Homo sapiens_hsa042600.91106905
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90395009
60Metabolic pathways_Homo sapiens_hsa011000.89377778
61Mineral absorption_Homo sapiens_hsa049780.87337416
62N-Glycan biosynthesis_Homo sapiens_hsa005100.86826841
63beta-Alanine metabolism_Homo sapiens_hsa004100.86323224
64Vitamin B6 metabolism_Homo sapiens_hsa007500.85809683
65Fatty acid metabolism_Homo sapiens_hsa012120.80606310
66Vibrio cholerae infection_Homo sapiens_hsa051100.75504599
67Cell cycle_Homo sapiens_hsa041100.74951618
68Phenylalanine metabolism_Homo sapiens_hsa003600.67611477
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67153589
70Regulation of autophagy_Homo sapiens_hsa041400.66723699
71Sulfur metabolism_Homo sapiens_hsa009200.66450399
72Fructose and mannose metabolism_Homo sapiens_hsa000510.66429143
73Oocyte meiosis_Homo sapiens_hsa041140.66160253
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65995238
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65805999
76Tryptophan metabolism_Homo sapiens_hsa003800.65784302
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.64557250
78Peroxisome_Homo sapiens_hsa041460.62531691
79Other glycan degradation_Homo sapiens_hsa005110.56449782
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51951513
81Sphingolipid metabolism_Homo sapiens_hsa006000.47635908
82Hedgehog signaling pathway_Homo sapiens_hsa043400.44339162
83Arginine and proline metabolism_Homo sapiens_hsa003300.43803620
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.42688601
85Gap junction_Homo sapiens_hsa045400.36652065
86Fatty acid biosynthesis_Homo sapiens_hsa000610.35086613
87mRNA surveillance pathway_Homo sapiens_hsa030150.32608832
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32407234
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30270200
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30165120
91Retinol metabolism_Homo sapiens_hsa008300.30121924
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27664335
93p53 signaling pathway_Homo sapiens_hsa041150.25416920
94Alcoholism_Homo sapiens_hsa050340.24835739
95Galactose metabolism_Homo sapiens_hsa000520.24612156
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.23987696
97TGF-beta signaling pathway_Homo sapiens_hsa043500.22546707
98Vitamin digestion and absorption_Homo sapiens_hsa049770.22010359
99Systemic lupus erythematosus_Homo sapiens_hsa053220.21656379
100Olfactory transduction_Homo sapiens_hsa047400.21592951

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