C1QTNF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular extravasation (GO:0045123)8.18570019
2regulation of chemokine biosynthetic process (GO:0045073)7.97789563
3negative regulation of phagocytosis (GO:0050765)6.92473162
4disruption of cells of other organism involved in symbiotic interaction (GO:0051818)6.85370742
5killing of cells in other organism involved in symbiotic interaction (GO:0051883)6.85370742
6regulation of short-term neuronal synaptic plasticity (GO:0048172)6.38347286
7synaptic vesicle maturation (GO:0016188)6.25362824
8neutrophil mediated immunity (GO:0002446)6.00440475
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.96797828
10locomotory exploration behavior (GO:0035641)5.91355429
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.86796699
12modulation of growth of symbiont involved in interaction with host (GO:0044144)5.81453685
13regulation of growth of symbiont in host (GO:0044126)5.81453685
14negative regulation of growth of symbiont in host (GO:0044130)5.81453685
15negative regulation of growth of symbiont involved in interaction with host (GO:0044146)5.81453685
16positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)5.80123103
17positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.73058367
18pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.70546509
19microglial cell activation (GO:0001774)5.67895966
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.64454591
21vocalization behavior (GO:0071625)5.44370733
22regulation of glutamate receptor signaling pathway (GO:1900449)5.42365238
23synaptic vesicle exocytosis (GO:0016079)5.20161706
24regulation of MHC class II biosynthetic process (GO:0045346)4.99828164
25regulation of synaptic vesicle exocytosis (GO:2000300)4.98992172
26ionotropic glutamate receptor signaling pathway (GO:0035235)4.94426446
27glutamate secretion (GO:0014047)4.89089452
28deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.87616234
29synaptic vesicle docking involved in exocytosis (GO:0016081)4.86957348
30pyrimidine nucleotide catabolic process (GO:0006244)4.84232947
31protein localization to synapse (GO:0035418)4.82776591
32positive regulation of chemokine biosynthetic process (GO:0045080)4.77499384
33regulation of neuronal synaptic plasticity (GO:0048168)4.70133213
34synaptic transmission, glutamatergic (GO:0035249)4.63350338
35exploration behavior (GO:0035640)4.63242846
36regulation of synapse structural plasticity (GO:0051823)4.58930123
37regulation of long-term neuronal synaptic plasticity (GO:0048169)4.57766992
38regulation of synaptic vesicle transport (GO:1902803)4.54420966
39myeloid leukocyte mediated immunity (GO:0002444)4.48408098
40negative regulation of B cell apoptotic process (GO:0002903)4.47208999
41dendritic spine morphogenesis (GO:0060997)4.39328650
42neuronal action potential propagation (GO:0019227)4.38523541
43deoxyribonucleotide catabolic process (GO:0009264)4.37054938
44neurotransmitter secretion (GO:0007269)4.36262316
45layer formation in cerebral cortex (GO:0021819)4.22412267
46glutamate receptor signaling pathway (GO:0007215)4.19405568
47neuron-neuron synaptic transmission (GO:0007270)4.13872180
48positive regulation of B cell differentiation (GO:0045579)4.08209931
49neurotransmitter-gated ion channel clustering (GO:0072578)4.03834625
50neuron cell-cell adhesion (GO:0007158)4.02260856
51deoxyribose phosphate catabolic process (GO:0046386)4.00768009
52long-term memory (GO:0007616)4.00496154
53positive regulation of membrane potential (GO:0045838)3.98067351
54reactive oxygen species biosynthetic process (GO:1903409)3.89572285
55purine deoxyribonucleotide catabolic process (GO:0009155)3.85499499
56negative regulation of chemokine production (GO:0032682)3.84263708
57gamma-aminobutyric acid transport (GO:0015812)3.84004132
58positive regulation of synaptic transmission, GABAergic (GO:0032230)3.83400822
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.82129201
60negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.80503056
61regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.79601818
62regulation of excitatory postsynaptic membrane potential (GO:0060079)3.78367791
63positive regulation of synapse maturation (GO:0090129)3.69572606
64prepulse inhibition (GO:0060134)3.69159129
65regulation of dendritic spine morphogenesis (GO:0061001)3.67597726
66calcium ion-dependent exocytosis (GO:0017156)3.67304005
67Peyers patch development (GO:0048541)3.63415096
68mucosal-associated lymphoid tissue development (GO:0048537)3.63415096
69transmission of nerve impulse (GO:0019226)3.61846470
70regulation of synaptic plasticity (GO:0048167)3.59247987
71auditory behavior (GO:0031223)3.58179913
72cellular potassium ion homeostasis (GO:0030007)3.57408984
73pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.56077297
74positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.55058256
75regulation of postsynaptic membrane potential (GO:0060078)3.54696477
76neuromuscular process controlling balance (GO:0050885)3.54573576
77regulation of interleukin-8 biosynthetic process (GO:0045414)3.48894886
78positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.48434009
79activation of protein kinase A activity (GO:0034199)3.46739161
80regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.45260227
81sodium ion export (GO:0071436)3.44444879
82removal of superoxide radicals (GO:0019430)3.41925973
83cellular response to superoxide (GO:0071451)3.41925973
84cellular response to oxygen radical (GO:0071450)3.41925973
85macrophage chemotaxis (GO:0048246)3.41777882
86regulation of synaptic transmission, glutamatergic (GO:0051966)3.41475854
87neurotransmitter transport (GO:0006836)3.40584108
88glial cell migration (GO:0008347)3.40082986
89dendritic spine organization (GO:0097061)3.39411065
90G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.39111274
91neuronal ion channel clustering (GO:0045161)3.38253156
92regulation of neurotransmitter secretion (GO:0046928)3.38047929
93regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.37623751
942-deoxyribonucleotide metabolic process (GO:0009394)3.34201011
95positive regulation of neurotransmitter secretion (GO:0001956)3.32907966
96induction of positive chemotaxis (GO:0050930)3.32698770
97membrane depolarization during action potential (GO:0086010)3.31013180
98positive regulation of neurotransmitter transport (GO:0051590)3.31011784
99G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.30485550
100response to auditory stimulus (GO:0010996)3.30110767
101neuron recognition (GO:0008038)3.28165592
102negative regulation of interleukin-8 production (GO:0032717)3.25942027
103neuromuscular process controlling posture (GO:0050884)3.25869315
104positive regulation of dendritic spine development (GO:0060999)3.25450905
105cell communication by electrical coupling (GO:0010644)3.23306169
106regulation of vesicle fusion (GO:0031338)3.23270200
107postsynaptic membrane organization (GO:0001941)3.21514054
108glycine transport (GO:0015816)3.21272783
109regulation of neurotransmitter levels (GO:0001505)3.20548597
110hydrogen peroxide catabolic process (GO:0042744)3.20031881
111membrane depolarization (GO:0051899)3.19246214
112cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.18206716
1132-deoxyribonucleotide biosynthetic process (GO:0009265)3.16957527
114deoxyribose phosphate biosynthetic process (GO:0046385)3.16957527
115purine deoxyribonucleotide metabolic process (GO:0009151)3.16426529
116mature B cell differentiation involved in immune response (GO:0002313)3.14919361
117long-term synaptic potentiation (GO:0060291)3.13820933
118proline transport (GO:0015824)3.13650247
119regulation of neurotransmitter transport (GO:0051588)3.13244786
120behavioral defense response (GO:0002209)3.12302119
121behavioral fear response (GO:0001662)3.12302119
122cerebellar Purkinje cell differentiation (GO:0021702)3.11436354
123axonal fasciculation (GO:0007413)3.08840412
124cerebellar Purkinje cell layer development (GO:0021680)3.07873219
125sperm motility (GO:0030317)3.06289263
126regulation of dendritic spine development (GO:0060998)3.05989014
127learning (GO:0007612)3.05322381
128adult walking behavior (GO:0007628)3.04163718
129membrane hyperpolarization (GO:0060081)3.03609506
130regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.02393340
131killing of cells of other organism (GO:0031640)3.01634728
132disruption of cells of other organism (GO:0044364)3.01634728
133synaptic vesicle endocytosis (GO:0048488)3.00804711
134deoxyribose phosphate metabolic process (GO:0019692)2.99114643
135female mating behavior (GO:0060180)2.98579958
136acrosome reaction (GO:0007340)2.98108792
137chemosensory behavior (GO:0007635)2.96040284
138regulation of synaptic transmission (GO:0050804)2.95987218
139positive regulation of dendritic spine morphogenesis (GO:0061003)2.95892304
140regulation of female receptivity (GO:0045924)2.95770155
141social behavior (GO:0035176)2.95107127
142intraspecies interaction between organisms (GO:0051703)2.95107127
143regulation of ARF protein signal transduction (GO:0032012)2.93710332
144mannosylation (GO:0097502)2.93104717
145establishment of mitochondrion localization (GO:0051654)2.92671273
146positive regulation of synaptic transmission (GO:0050806)2.92492732
147dendrite morphogenesis (GO:0048813)2.91425505
148fear response (GO:0042596)2.91191169
149regulation of glutamate secretion (GO:0014048)2.91107872
150synaptic transmission (GO:0007268)2.90406903
151ribosomal small subunit assembly (GO:0000028)2.90138999
152dopamine receptor signaling pathway (GO:0007212)2.89289017
153mast cell activation involved in immune response (GO:0002279)2.88866275
154mast cell degranulation (GO:0043303)2.88866275
155protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)2.78394367
156mitochondrion transport along microtubule (GO:0047497)2.77489230
157establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.77489230
158response to superoxide (GO:0000303)2.76523846
159mechanosensory behavior (GO:0007638)2.75951489
160deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.73396124
161regulation of B cell apoptotic process (GO:0002902)2.68530159
162mitochondrial respiratory chain complex I assembly (GO:0032981)2.67239374
163NADH dehydrogenase complex assembly (GO:0010257)2.67239374
164mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.67239374
165macrophage activation (GO:0042116)2.66667082
166lipopolysaccharide biosynthetic process (GO:0009103)2.66608387
167alanine transport (GO:0032328)2.66039019
168GDP-mannose metabolic process (GO:0019673)2.65522468
169protein complex biogenesis (GO:0070271)2.62630594
170regulation of phagocytosis (GO:0050764)2.62527324
171viral transcription (GO:0019083)2.59283639
172post-embryonic morphogenesis (GO:0009886)2.58697840
173deoxyribonucleotide metabolic process (GO:0009262)2.56986975
174chaperone-mediated protein transport (GO:0072321)2.56370855
175response to oxygen radical (GO:0000305)2.54458126
176cellular response to interferon-beta (GO:0035458)2.53391232
177cellular response to exogenous dsRNA (GO:0071360)2.52049327
178lysosome localization (GO:0032418)2.50582602
179response to fungus (GO:0009620)2.49560782
180regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.48796859
181regulation of dopamine metabolic process (GO:0042053)2.47618652
182regulation of catecholamine metabolic process (GO:0042069)2.47618652

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.15980243
2VDR_21846776_ChIP-Seq_THP-1_Human4.17510207
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.79043450
4REST_21632747_ChIP-Seq_MESCs_Mouse3.10233171
5* RARB_27405468_Chip-Seq_BRAIN_Mouse2.98153468
6SCL_19346495_ChIP-Seq_HPC-7_Human2.93609424
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.92056504
8* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.87836182
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77070962
10* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.62774777
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59979503
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.58916823
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.58916823
14GBX2_23144817_ChIP-Seq_PC3_Human2.57393579
15* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.55920156
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.55527150
17DROSHA_22980978_ChIP-Seq_HELA_Human2.55188070
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.49825338
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.49445881
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.49140873
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.48617807
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.41523476
23* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33898719
24* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32554188
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.31622131
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.28402887
27VDR_24763502_ChIP-Seq_THP-1_Human2.24947336
28* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23845553
29TET1_21451524_ChIP-Seq_MESCs_Mouse2.23750558
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.18783645
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.10688834
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.06094318
33EED_16625203_ChIP-ChIP_MESCs_Mouse2.02434764
34* P68_20966046_ChIP-Seq_HELA_Human1.95481280
35* ELF1_20517297_ChIP-Seq_JURKAT_Human1.92528816
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.87171639
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.86732969
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.86111869
39EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.84617506
40CIITA_25753668_ChIP-Seq_RAJI_Human1.80451448
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.78918604
42* BCL6_27268052_Chip-Seq_Bcells_Human1.74832833
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71662013
44RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.69601412
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.69450544
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69381240
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.68790420
48ZNF274_21170338_ChIP-Seq_K562_Hela1.65958067
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.62980742
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.57361121
51EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.53517411
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.53263518
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52682615
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.51323824
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.51003988
56YY1_22570637_ChIP-Seq_MALME-3M_Human1.50830406
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49060459
58SPI1_20517297_ChIP-Seq_HL60_Human1.48147871
59NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46989064
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46834729
61CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.45460294
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43231691
63* RING1B_27294783_Chip-Seq_ESCs_Mouse1.40830667
64CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.40380321
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39861612
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39673404
67FOXP1_21924763_ChIP-Seq_HESCs_Human1.39360541
68SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.38009098
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37950983
70DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37387474
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.37123302
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34697253
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34601187
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34024084
75UTX_26944678_Chip-Seq_JUKART_Human1.33803255
76MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.32714681
77CTCF_18555785_ChIP-Seq_MESCs_Mouse1.32431473
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32378552
79* PHF8_20622854_ChIP-Seq_HELA_Human1.30508312
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.30180963
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28759914
82EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28304932
83RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.25963962
84CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25845323
85ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25666054
86HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24470914
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24236668
88KDM2B_26808549_Chip-Seq_K562_Human1.23547203
89SRF_21415370_ChIP-Seq_HL-1_Mouse1.23366459
90BCOR_27268052_Chip-Seq_Bcells_Human1.22839070
91CTCF_21964334_ChIP-Seq_BJAB-B_Human1.22459828
92* E2F1_20622854_ChIP-Seq_HELA_Human1.22434666
93MYC_18555785_ChIP-Seq_MESCs_Mouse1.21926022
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21218804
95CTCF_26484167_Chip-Seq_Bcells_Mouse1.21002636
96* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.19690301
97SMAD4_21799915_ChIP-Seq_A2780_Human1.19558165
98* CTCF_27219007_Chip-Seq_Bcells_Human1.18174686
99GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17900926
100STAT1_20625510_ChIP-Seq_HELA_Human1.17286992
101ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16071672
102CBX2_27304074_Chip-Seq_ESCs_Mouse1.15840578
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15346243
104GABP_19822575_ChIP-Seq_HepG2_Human1.14207590
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13883534
106CTCF_20526341_ChIP-Seq_ESCs_Human1.13842284
107SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13757990
108P300_27268052_Chip-Seq_Bcells_Human1.13439008
109PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12578520
110SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11647271
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11328060
112ERA_21632823_ChIP-Seq_H3396_Human1.10877020
113MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10798371
114PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09743739
115RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.08404088
116PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07730458
117RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07727484
118* MAF_26560356_Chip-Seq_TH2_Human1.07449808
119RING1B_27294783_Chip-Seq_NPCs_Mouse1.07366679
120TET1_21490601_ChIP-Seq_MESCs_Mouse1.06374761
121AR_21572438_ChIP-Seq_LNCaP_Human1.06262429
122RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05749637
123BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.05162707
124IGF1R_20145208_ChIP-Seq_DFB_Human1.04749581
125GATA1_19941827_ChIP-Seq_MEL_Mouse1.03790417
126SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03107561
127HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02595749
128WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02176365
129AR_19668381_ChIP-Seq_PC3_Human1.01131067
130GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99971432
131RNF2_27304074_Chip-Seq_NSC_Mouse0.98938289
132SMAD3_21741376_ChIP-Seq_ESCs_Human0.98740819
133BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98417617
134* SOX2_21211035_ChIP-Seq_LN229_Gbm0.98094415
135GATA1_26923725_Chip-Seq_HPCs_Mouse0.97634718
136SMAD3_21741376_ChIP-Seq_EPCs_Human0.97628923
137TAF15_26573619_Chip-Seq_HEK293_Human0.96011793
138* SMC4_20622854_ChIP-Seq_HELA_Human0.94923842
139AR_25329375_ChIP-Seq_VCAP_Human0.94521631
140GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94282507
141KLF4_19829295_ChIP-Seq_ESCs_Human0.93844765
142NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92701908
143TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92393140
144OCT4_19829295_ChIP-Seq_ESCs_Human0.91039016
145PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90127549
146P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90004934
147WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89922030
148ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89907393
149LXR_22292898_ChIP-Seq_THP-1_Human0.89606969
150ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89332138
151STAT3_23295773_ChIP-Seq_U87_Human0.87402750
152TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87005014
153ELK4_26923725_Chip-Seq_MESODERM_Mouse0.84719513
154TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82950765
155BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.82911515
156TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81984744
157POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.81984744
158OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.81751271
159P300_19829295_ChIP-Seq_ESCs_Human0.80753380
160NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80470118
161TCF4_23295773_ChIP-Seq_U87_Human0.79099618
162TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.78804526
163SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78605316
164WDR5_24793694_ChIP-Seq_LNCAP_Human0.77754698
165YAP1_20516196_ChIP-Seq_MESCs_Mouse0.77481946
166MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.75049467
167SMAD3_21741376_ChIP-Seq_HESCs_Human0.74800041
168* SMAD4_21741376_ChIP-Seq_HESCs_Human0.73688170
169TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.73179824
170TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73155286
171SMAD4_21741376_ChIP-Seq_EPCs_Human0.72740304

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.93883841
2MP0003880_abnormal_central_pattern4.47258488
3MP0003635_abnormal_synaptic_transmissio4.33991573
4MP0002822_catalepsy3.70043542
5MP0004270_analgesia3.55136177
6MP0002063_abnormal_learning/memory/cond3.51164565
7MP0009745_abnormal_behavioral_response3.46959593
8MP0002064_seizures3.08325854
9MP0009046_muscle_twitch2.91094830
10MP0002572_abnormal_emotion/affect_behav2.79433169
11MP0005410_abnormal_fertilization2.72755347
12MP0005423_abnormal_somatic_nervous2.72110177
13MP0001968_abnormal_touch/_nociception2.67141820
14MP0002272_abnormal_nervous_system2.54229339
15MP0001486_abnormal_startle_reflex2.53864215
16MP0002734_abnormal_mechanical_nocicepti2.40224712
17MP0009278_abnormal_bone_marrow2.29892427
18MP0004147_increased_porphyrin_level2.26713630
19MP0009379_abnormal_foot_pigmentation2.16253865
20MP0001501_abnormal_sleep_pattern2.09193962
21MP0001986_abnormal_taste_sensitivity2.02823626
22MP0002909_abnormal_adrenal_gland2.02256283
23MP0002736_abnormal_nociception_after2.01120052
24MP0001440_abnormal_grooming_behavior1.98539465
25MP0001545_abnormal_hematopoietic_system1.98162344
26MP0005397_hematopoietic_system_phenotyp1.98162344
27MP0008569_lethality_at_weaning1.91162364
28MP0005075_abnormal_melanosome_morpholog1.89956930
29MP0002733_abnormal_thermal_nociception1.88039726
30MP0004811_abnormal_neuron_physiology1.87493099
31MP0001984_abnormal_olfaction1.84955862
32MP0003329_amyloid_beta_deposits1.83847941
33MP0001970_abnormal_pain_threshold1.82648861
34MP0002557_abnormal_social/conspecific_i1.80792532
35MP0003123_paternal_imprinting1.79739379
36MP0002735_abnormal_chemical_nociception1.76808449
37MP0003121_genomic_imprinting1.76677454
38MP0002184_abnormal_innervation1.72606344
39MP0004858_abnormal_nervous_system1.72197263
40MP0003879_abnormal_hair_cell1.71739374
41MP0002067_abnormal_sensory_capabilities1.71472511
42MP0009780_abnormal_chondrocyte_physiolo1.69203686
43MP0005174_abnormal_tail_pigmentation1.66290742
44MP0003183_abnormal_peptide_metabolism1.64214926
45MP0003172_abnormal_lysosome_physiology1.61244945
46MP0005464_abnormal_platelet_physiology1.59010038
47MP0000778_abnormal_nervous_system1.57533671
48MP0004885_abnormal_endolymph1.56588205
49MP0000955_abnormal_spinal_cord1.56173510
50MP0005386_behavior/neurological_phenoty1.56082043
51MP0004924_abnormal_behavior1.56082043
52MP0005646_abnormal_pituitary_gland1.53252186
53MP0001529_abnormal_vocalization1.45532995
54MP0002882_abnormal_neuron_morphology1.39742245
55MP0002066_abnormal_motor_capabilities/c1.39556770
56MP0006036_abnormal_mitochondrial_physio1.36798229
57MP0001502_abnormal_circadian_rhythm1.36724460
58MP0006276_abnormal_autonomic_nervous1.33098599
59MP0003633_abnormal_nervous_system1.30672261
60MP0004142_abnormal_muscle_tone1.29241223
61MP0003283_abnormal_digestive_organ1.27763622
62MP0000372_irregular_coat_pigmentation1.27695201
63MP0003787_abnormal_imprinting1.26405538
64MP0003698_abnormal_male_reproductive1.22065384
65MP0005645_abnormal_hypothalamus_physiol1.21473921
66MP0001905_abnormal_dopamine_level1.21046267
67MP0006292_abnormal_olfactory_placode1.20732587
68MP0008961_abnormal_basal_metabolism1.17609708
69MP0003122_maternal_imprinting1.15698925
70MP0002152_abnormal_brain_morphology1.14002244
71MP0000013_abnormal_adipose_tissue1.12997904
72MP0002396_abnormal_hematopoietic_system1.10879023
73MP0008058_abnormal_DNA_repair1.10600439
74MP0003075_altered_response_to1.10434232
75MP0000681_abnormal_thyroid_gland1.10152128
76MP0000015_abnormal_ear_pigmentation1.08713104
77MP0002095_abnormal_skin_pigmentation1.08217317
78MP0005025_abnormal_response_to1.07539193
79MP0000751_myopathy1.07141196
80MP0003631_nervous_system_phenotype1.06499360
81MP0008873_increased_physiological_sensi1.05196171
82MP0002419_abnormal_innate_immunity1.04171717
83MP0003303_peritoneal_inflammation1.01413524
84MP0002069_abnormal_eating/drinking_beha0.98099396
85MP0004145_abnormal_muscle_electrophysio0.97309390
86MP0003806_abnormal_nucleotide_metabolis0.97275579
87MP0008872_abnormal_physiological_respon0.93640082
88MP0008877_abnormal_DNA_methylation0.91255362
89MP0008995_early_reproductive_senescence0.91026389
90MP0001485_abnormal_pinna_reflex0.90170614
91MP0005084_abnormal_gallbladder_morpholo0.90010093
92MP0005220_abnormal_exocrine_pancreas0.89389456
93MP0000465_gastrointestinal_hemorrhage0.89303200
94MP0010386_abnormal_urinary_bladder0.88578664
95MP0004233_abnormal_muscle_weight0.86668913
96MP0002229_neurodegeneration0.86267202
97MP0005167_abnormal_blood-brain_barrier0.84118881
98MP0005535_abnormal_body_temperature0.83955944
99MP0004742_abnormal_vestibular_system0.83270846
100MP0002876_abnormal_thyroid_physiology0.83056517
101MP0008874_decreased_physiological_sensi0.81115246
102MP0001177_atelectasis0.80850915
103MP0002234_abnormal_pharynx_morphology0.80220971
104MP0004085_abnormal_heartbeat0.80167350
105MP0002160_abnormal_reproductive_system0.79364048
106MP0005551_abnormal_eye_electrophysiolog0.78452676
107MP0000631_abnormal_neuroendocrine_gland0.75263848
108MP0001929_abnormal_gametogenesis0.75105659
109MP0003646_muscle_fatigue0.73375402
110MP0000604_amyloidosis0.73078494
111MP0004808_abnormal_hematopoietic_stem0.72720465
112MP0005266_abnormal_metabolism0.72207269
113MP0003634_abnormal_glial_cell0.70314522
114MP0002420_abnormal_adaptive_immunity0.70169493
115MP0002653_abnormal_ependyma_morphology0.70072464
116MP0002752_abnormal_somatic_nervous0.69584920
117MP0004043_abnormal_pH_regulation0.69032451
118MP0003436_decreased_susceptibility_to0.68316762
119MP0002638_abnormal_pupillary_reflex0.68243205
120MP0001963_abnormal_hearing_physiology0.67738084
121MP0001819_abnormal_immune_cell0.67521645
122MP0003690_abnormal_glial_cell0.66413670
123MP0002161_abnormal_fertility/fecundity0.66397216
124MP0004185_abnormal_adipocyte_glucose0.65930191
125MP0005394_taste/olfaction_phenotype0.65636042
126MP0005499_abnormal_olfactory_system0.65636042
127MP0003137_abnormal_impulse_conducting0.65192692
128MP0002837_dystrophic_cardiac_calcinosis0.65080320
129MP0003632_abnormal_nervous_system0.64661389
130MP0001764_abnormal_homeostasis0.63916571
131MP0000569_abnormal_digit_pigmentation0.62750752
132MP0002090_abnormal_vision0.62540032
133MP0003861_abnormal_nervous_system0.61733789
134MP0005623_abnormal_meninges_morphology0.60767107
135MP0001664_abnormal_digestion0.60376440
136MP0001765_abnormal_ion_homeostasis0.58297896
137MP0001188_hyperpigmentation0.58242085
138MP0000920_abnormal_myelination0.56401018
139MP0004130_abnormal_muscle_cell0.53935431

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.44024567
2Thrombocytosis (HP:0001894)7.41819853
3Focal motor seizures (HP:0011153)6.82748144
4Visual hallucinations (HP:0002367)5.42473975
5Focal seizures (HP:0007359)5.09814505
6Abnormality of the prostate (HP:0008775)4.71347246
7Agammaglobulinemia (HP:0004432)4.17436747
8Epileptic encephalopathy (HP:0200134)4.11369485
9Ankle clonus (HP:0011448)4.00405011
10Progressive cerebellar ataxia (HP:0002073)3.97844920
11Obstructive lung disease (HP:0006536)3.95216715
12Chronic obstructive pulmonary disease (HP:0006510)3.95216715
13Dynein arm defect of respiratory motile cilia (HP:0012255)3.94968440
14Absent/shortened dynein arms (HP:0200106)3.94968440
15Ureteral stenosis (HP:0000071)3.94069992
16Impaired vibration sensation in the lower limbs (HP:0002166)3.89651344
17Febrile seizures (HP:0002373)3.82842377
18Atonic seizures (HP:0010819)3.76948433
19Abnormality of the lower motor neuron (HP:0002366)3.72282466
20Elevated erythrocyte sedimentation rate (HP:0003565)3.68258733
21Granulocytopenia (HP:0001913)3.66168957
22Action tremor (HP:0002345)3.63956018
23Ureteral obstruction (HP:0006000)3.54594646
24Supranuclear gaze palsy (HP:0000605)3.53425713
25Absence seizures (HP:0002121)3.38985979
26Eosinophilia (HP:0001880)3.37458029
27Generalized tonic-clonic seizures (HP:0002069)3.35928356
28Urinary bladder sphincter dysfunction (HP:0002839)3.34354978
29Depression (HP:0000716)3.32873702
30Type I transferrin isoform profile (HP:0003642)3.25094503
31Ventricular fibrillation (HP:0001663)3.17892019
32Tubulointerstitial nephritis (HP:0001970)3.16994488
33Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.12830979
34Chest pain (HP:0100749)3.12737206
35Mutism (HP:0002300)3.12423055
36Spastic gait (HP:0002064)3.10723000
37Gaze-evoked nystagmus (HP:0000640)3.10631620
38Anxiety (HP:0000739)3.10468939
39Broad-based gait (HP:0002136)3.09568632
40Dialeptic seizures (HP:0011146)3.08890906
41Urinary urgency (HP:0000012)3.02870826
42Hepatocellular necrosis (HP:0001404)3.01578718
43Periodontitis (HP:0000704)3.00486707
44Postural instability (HP:0002172)2.98593832
45Poor eye contact (HP:0000817)2.98075572
46Increased neuronal autofluorescent lipopigment (HP:0002074)2.97795791
47Abnormality of male internal genitalia (HP:0000022)2.96485443
48Dysdiadochokinesis (HP:0002075)2.94450619
49Torticollis (HP:0000473)2.92435936
50Abnormal eating behavior (HP:0100738)2.89717485
51Bundle branch block (HP:0011710)2.88879482
52Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.88456409
53Genetic anticipation (HP:0003743)2.85909723
54Increased muscle lipid content (HP:0009058)2.85116792
55Hemiparesis (HP:0001269)2.79634796
56Cerebral hypomyelination (HP:0006808)2.78542128
57Abnormal respiratory motile cilium physiology (HP:0012261)2.77718929
58Focal dystonia (HP:0004373)2.76791655
59Dysmetria (HP:0001310)2.75467162
60Abnormality of eosinophils (HP:0001879)2.71180215
61Abnormal respiratory epithelium morphology (HP:0012253)2.70237117
62Abnormal respiratory motile cilium morphology (HP:0005938)2.70237117
63Impaired social interactions (HP:0000735)2.68865244
64Abnormal social behavior (HP:0012433)2.68865244
65Annular pancreas (HP:0001734)2.68793334
66Impaired smooth pursuit (HP:0007772)2.68320563
67Hepatic necrosis (HP:0002605)2.66063084
68Mitochondrial inheritance (HP:0001427)2.64212939
69Reticulocytopenia (HP:0001896)2.63987078
70Truncal ataxia (HP:0002078)2.62825892
71Amblyopia (HP:0000646)2.62076006
72Progressive microcephaly (HP:0000253)2.60616820
73Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.56946210
74Meningitis (HP:0001287)2.54645881
75Increased intramyocellular lipid droplets (HP:0012240)2.54543533
76Neurofibrillary tangles (HP:0002185)2.53410661
77Impaired vibratory sensation (HP:0002495)2.51500408
78Increased cerebral lipofuscin (HP:0011813)2.50365972
79Acute lymphatic leukemia (HP:0006721)2.49503758
80Craniofacial dystonia (HP:0012179)2.49353065
81Pulmonary fibrosis (HP:0002206)2.49053524
82Intention tremor (HP:0002080)2.48993017
83Papilledema (HP:0001085)2.48804891
84Amyotrophic lateral sclerosis (HP:0007354)2.48420182
85Abnormality of ocular smooth pursuit (HP:0000617)2.42324794
86Bradykinesia (HP:0002067)2.42065289
87Stereotypic behavior (HP:0000733)2.39331068
88Abnormal mitochondria in muscle tissue (HP:0008316)2.39317999
89Infertility (HP:0000789)2.38984640
90Hypergammaglobulinemia (HP:0010702)2.37913630
91Cerebral inclusion bodies (HP:0100314)2.37880991
92Insomnia (HP:0100785)2.36607257
93Skin rash (HP:0000988)2.35235717
94Abnormal ciliary motility (HP:0012262)2.34537376
95Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.34230915
96Abnormal protein N-linked glycosylation (HP:0012347)2.34230915
97Abnormal protein glycosylation (HP:0012346)2.34230915
98Abnormal glycosylation (HP:0012345)2.34230915
99Drooling (HP:0002307)2.33210835
100Excessive salivation (HP:0003781)2.33210835
101Progressive inability to walk (HP:0002505)2.31831370
102Rhinitis (HP:0012384)2.31579915
103Hemiplegia (HP:0002301)2.29089381
104Neoplasm of the heart (HP:0100544)2.29056536
105Panhypogammaglobulinemia (HP:0003139)2.26994118
106Ragged-red muscle fibers (HP:0003200)2.26688712
107B lymphocytopenia (HP:0010976)2.25511996
108Lipid accumulation in hepatocytes (HP:0006561)2.25092343
109Delusions (HP:0000746)2.24926705
110Dysmetric saccades (HP:0000641)2.24301712
111Polyphagia (HP:0002591)2.23388598
112Microvesicular hepatic steatosis (HP:0001414)2.21973225
113Acute necrotizing encephalopathy (HP:0006965)2.20512454
114Clonus (HP:0002169)2.20218242
115Lower limb muscle weakness (HP:0007340)2.20113823
116Increased CSF lactate (HP:0002490)2.19777783
117Emotional lability (HP:0000712)2.19034883
118Congenital stationary night blindness (HP:0007642)2.18073703
119Limb dystonia (HP:0002451)2.17753051
120Abnormality of B cell number (HP:0010975)2.17684147
121Absent speech (HP:0001344)2.17468721
122Decreased central vision (HP:0007663)2.16373313
123Pointed chin (HP:0000307)2.16030881
124Megalencephaly (HP:0001355)2.15267524
125Abnormal EKG (HP:0003115)2.13606161
126Failure to thrive in infancy (HP:0001531)2.10215509
127Sepsis (HP:0100806)2.09461621
128Agitation (HP:0000713)2.08624112
129Diplopia (HP:0000651)2.07226516
130Abnormality of binocular vision (HP:0011514)2.07226516
131Reduced antithrombin III activity (HP:0001976)2.06646373
132Epileptiform EEG discharges (HP:0011182)2.05100004
133Abnormality of the pleura (HP:0002103)2.03180168
134Scanning speech (HP:0002168)2.00954531
135EEG with generalized epileptiform discharges (HP:0011198)1.98760081
136Hyperventilation (HP:0002883)1.98245800
137Gangrene (HP:0100758)1.97109464
138Abnormal number of erythroid precursors (HP:0012131)1.96691186
139Leukocytosis (HP:0001974)1.96379665
140Acute encephalopathy (HP:0006846)1.95152369
141Neutropenia (HP:0001875)1.94552217
142Periorbital edema (HP:0100539)1.94297289
143Cellulitis (HP:0100658)1.93614026
144Status epilepticus (HP:0002133)1.93068297
145Resting tremor (HP:0002322)1.91601125
146Hypsarrhythmia (HP:0002521)1.91491940
147Chronic bronchitis (HP:0004469)1.90919386
148Dicarboxylic aciduria (HP:0003215)1.90635788
149Abnormality of dicarboxylic acid metabolism (HP:0010995)1.90635788
150Incomplete penetrance (HP:0003829)1.89900793
151Neuronal loss in central nervous system (HP:0002529)1.87868153
152Muscle stiffness (HP:0003552)1.87258550
153Abnormality of the corticospinal tract (HP:0002492)1.85373123
154Facial edema (HP:0000282)1.83056265
155Apathy (HP:0000741)1.83019489
156Anomalous pulmonary venous return (HP:0010772)1.82534257
157Abnormality of saccadic eye movements (HP:0000570)1.81706000
158Tetraplegia (HP:0002445)1.81440573
159Pulmonary infiltrates (HP:0002113)1.81362508
160Abnormality of cells of the erythroid lineage (HP:0012130)1.80674635
161Epistaxis (HP:0000421)1.79892758
162Anosmia (HP:0000458)1.79110748
163Gait ataxia (HP:0002066)1.79018984
164Truncus arteriosus (HP:0001660)1.78567666
165Specific learning disability (HP:0001328)1.77592237
166Fetal akinesia sequence (HP:0001989)1.76174718
167Hyperthyroidism (HP:0000836)1.75670435
168Type II lissencephaly (HP:0007260)1.75094104
169Hemoptysis (HP:0002105)1.74947001
170Thrombophlebitis (HP:0004418)1.74636036
171Termporal pattern (HP:0011008)1.73491425
172Insidious onset (HP:0003587)1.73491425
173Inability to walk (HP:0002540)1.72410186
174Limb ataxia (HP:0002070)1.72148616
175Progressive macrocephaly (HP:0004481)1.71324653
176Exercise intolerance (HP:0003546)1.70882096
177Increased hepatocellular lipid droplets (HP:0006565)1.69714839
178Migraine (HP:0002076)1.68976791
179Abnormality of the pericardium (HP:0001697)1.67195203

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.97402748
2BCKDK4.28244103
3NTRK33.98266669
4MAP3K93.72337543
5INSRR3.68335145
6ERN13.45930780
7VRK23.31535335
8PRKD33.24793997
9TESK23.00122976
10MARK12.76033511
11MAP4K22.72394102
12MAP3K112.59984644
13PIM22.59056635
14DAPK22.49440033
15KIT2.43517581
16KDR2.40228567
17MINK12.39740780
18KSR22.39662342
19MAP3K42.20145079
20PAK62.16944242
21CAMKK12.10153885
22NTRK21.95076051
23KSR11.90263326
24ARAF1.89744198
25TAOK31.87229272
26MAP2K71.76206936
27PDK41.57411256
28PDK31.57411256
29STK381.56694118
30DAPK11.54024572
31PIK3CG1.52832266
32RIPK41.52399139
33NTRK11.51253616
34CDK51.49081908
35SCYL21.48615339
36CCNB11.47046452
37TYRO31.38857654
38MAP4K11.35530872
39TESK11.31431119
40SIK21.29451208
41NUAK11.27984258
42UHMK11.27684007
43PINK11.24826561
44ABL21.24262465
45MAP3K21.24127246
46PRKCG1.23744870
47GRK51.21879563
48CDC71.21191652
49PRPF4B1.20883832
50MARK21.19310617
51MAP2K41.19031574
52CAMK11.12897463
53DYRK21.12680572
54TAOK11.11636992
55MAPK131.09879191
56CDK191.08917830
57TNIK1.08413906
58MAP3K131.08374437
59FES1.05301377
60PTK2B1.04132097
61ICK1.01787718
62PLK21.01762632
63RPS6KA41.01648542
64PHKG11.01106115
65PHKG21.01106115
66SYK1.00765126
67CAMKK21.00139248
68CDK180.97311435
69MAP3K120.96260745
70CDK150.94389048
71NME20.91907459
72CDK30.90008889
73CSF1R0.89915970
74CDK140.89192582
75VRK10.84845661
76FLT30.83834460
77PRKD20.83548926
78CDK11A0.83291176
79PDK10.83259043
80RAF10.82880416
81STK110.81754992
82ATR0.81012377
83ZAK0.79576112
84PRKCH0.78122367
85PNCK0.76921655
86GRK60.76901757
87BRAF0.75731270
88CAMK2A0.75600194
89TBK10.74829157
90PDK20.74703589
91PDPK10.72740119
92TEC0.71566059
93ALK0.66430015
94MAP3K70.65318631
95PAK30.65101530
96CAMK40.64014657
97TRIM280.63733146
98DYRK1B0.62521238
99LMTK20.61975650
100MAPKAPK30.61738383
101DYRK1A0.61477440
102SGK2230.61420430
103SGK4940.61420430
104MATK0.61022228
105MAP3K10.60913951
106PRKCQ0.60775352
107MAPK40.60468469
108PRKCZ0.60342502
109CAMK2B0.59026214
110RPS6KA50.56858964
111CASK0.56283364
112IKBKE0.55855131
113BRSK10.54796837
114RET0.54664625
115PIK3CA0.52223555
116RPS6KL10.52022177
117RPS6KC10.52022177
118AURKA0.51612666
119SIK30.51237643
120LATS20.51076504
121RPS6KA60.50436378
122BMPR20.49942064
123SGK10.49637514
124CDC42BPA0.49212142
125BTK0.46273659
126HIPK20.45843768
127DAPK30.45834485
128PRKCA0.45016181
129WNK30.43598008
130SGK30.43267519
131WNK40.42357502
132RPS6KA30.42310132
133NEK10.41391452
134LIMK10.41210750
135PKN10.40315912
136RPS6KA20.39483523
137TNK20.39278337
138SGK20.38297712
139NME10.38206841
140LCK0.37920754
141NEK60.37657200
142CHEK20.36303348
143RIPK10.36234045
144MAP3K50.34690078
145MAP2K10.34517362
146GRK70.33439603
147MAPK100.33054848
148MAP2K60.32880634
149CAMK2G0.32563705
150CSNK1G20.30821466
151CAMK2D0.29803234

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.48903008
2Synaptic vesicle cycle_Homo sapiens_hsa047213.41507186
3Olfactory transduction_Homo sapiens_hsa047403.07245067
4Base excision repair_Homo sapiens_hsa034102.94652689
5Circadian entrainment_Homo sapiens_hsa047132.81477103
6Long-term potentiation_Homo sapiens_hsa047202.78156989
7Oxidative phosphorylation_Homo sapiens_hsa001902.75005390
8Amphetamine addiction_Homo sapiens_hsa050312.73779203
9Glutamatergic synapse_Homo sapiens_hsa047242.65750318
10Ribosome_Homo sapiens_hsa030102.65393291
11GABAergic synapse_Homo sapiens_hsa047272.62280119
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.57641720
13Morphine addiction_Homo sapiens_hsa050322.50288111
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.48127602
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.46845824
16Parkinsons disease_Homo sapiens_hsa050122.41254068
17DNA replication_Homo sapiens_hsa030302.35098898
18Insulin secretion_Homo sapiens_hsa049112.20160302
19Dopaminergic synapse_Homo sapiens_hsa047282.18201939
20Salivary secretion_Homo sapiens_hsa049702.12670296
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.11296103
22Cholinergic synapse_Homo sapiens_hsa047251.97294319
23Cocaine addiction_Homo sapiens_hsa050301.93983551
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.93383155
25Gastric acid secretion_Homo sapiens_hsa049711.87140628
26Asthma_Homo sapiens_hsa053101.81551807
27RNA polymerase_Homo sapiens_hsa030201.80856408
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.79356869
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.78781819
30Oxytocin signaling pathway_Homo sapiens_hsa049211.78327752
31Taste transduction_Homo sapiens_hsa047421.70502006
32Renin secretion_Homo sapiens_hsa049241.68755084
33Calcium signaling pathway_Homo sapiens_hsa040201.65290493
34Huntingtons disease_Homo sapiens_hsa050161.61628869
35Pyrimidine metabolism_Homo sapiens_hsa002401.58990503
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.52703106
37Long-term depression_Homo sapiens_hsa047301.50164624
38Serotonergic synapse_Homo sapiens_hsa047261.46164469
39Homologous recombination_Homo sapiens_hsa034401.44252811
40Peroxisome_Homo sapiens_hsa041461.41606549
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41316253
42GnRH signaling pathway_Homo sapiens_hsa049121.37678451
43Gap junction_Homo sapiens_hsa045401.35763653
44cAMP signaling pathway_Homo sapiens_hsa040241.33659866
45Collecting duct acid secretion_Homo sapiens_hsa049661.32471888
46Cardiac muscle contraction_Homo sapiens_hsa042601.31936289
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24817224
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.23620187
49Estrogen signaling pathway_Homo sapiens_hsa049151.23214992
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22725523
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22554102
52Type II diabetes mellitus_Homo sapiens_hsa049301.21753853
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17411075
54Primary immunodeficiency_Homo sapiens_hsa053401.14767023
55Renin-angiotensin system_Homo sapiens_hsa046141.14224641
56Oocyte meiosis_Homo sapiens_hsa041141.14034817
57cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12523877
58Glioma_Homo sapiens_hsa052141.08431669
59Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05231617
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04571047
61Axon guidance_Homo sapiens_hsa043601.04260987
62Vascular smooth muscle contraction_Homo sapiens_hsa042701.01552059
63Purine metabolism_Homo sapiens_hsa002301.01115103
64Melanogenesis_Homo sapiens_hsa049161.00607455
65Fanconi anemia pathway_Homo sapiens_hsa034600.99354606
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96209190
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93881316
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93658495
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93477604
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93270530
71Glucagon signaling pathway_Homo sapiens_hsa049220.90587241
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89722856
73Non-homologous end-joining_Homo sapiens_hsa034500.88971750
74ErbB signaling pathway_Homo sapiens_hsa040120.88337285
75Fatty acid elongation_Homo sapiens_hsa000620.87903106
76Nitrogen metabolism_Homo sapiens_hsa009100.86370257
77Vibrio cholerae infection_Homo sapiens_hsa051100.84129571
78Pancreatic secretion_Homo sapiens_hsa049720.84118980
79Butanoate metabolism_Homo sapiens_hsa006500.84028615
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.83580108
81Sulfur relay system_Homo sapiens_hsa041220.82964116
82Thyroid hormone synthesis_Homo sapiens_hsa049180.81840404
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81518271
84Dorso-ventral axis formation_Homo sapiens_hsa043200.81114492
85Alcoholism_Homo sapiens_hsa050340.79591162
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75515440
87Ether lipid metabolism_Homo sapiens_hsa005650.72798786
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72127736
89Acute myeloid leukemia_Homo sapiens_hsa052210.71188110
90Dilated cardiomyopathy_Homo sapiens_hsa054140.68922586
91Folate biosynthesis_Homo sapiens_hsa007900.67616683
92VEGF signaling pathway_Homo sapiens_hsa043700.67276928
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67006851
94Phototransduction_Homo sapiens_hsa047440.66991423
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.66873586
96Tryptophan metabolism_Homo sapiens_hsa003800.66695193
97Choline metabolism in cancer_Homo sapiens_hsa052310.65768580
98Regulation of autophagy_Homo sapiens_hsa041400.65465550
99Systemic lupus erythematosus_Homo sapiens_hsa053220.65112299
100Endocytosis_Homo sapiens_hsa041440.64763719
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62515206
102MAPK signaling pathway_Homo sapiens_hsa040100.61747167
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61517487
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.58356435
105mTOR signaling pathway_Homo sapiens_hsa041500.58017445
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57985467
107RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57440221
108Nucleotide excision repair_Homo sapiens_hsa034200.57397349
109Metabolic pathways_Homo sapiens_hsa011000.55960445
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55902180
111Type I diabetes mellitus_Homo sapiens_hsa049400.55257972
112Pentose phosphate pathway_Homo sapiens_hsa000300.55192496
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52842194
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.50969614
115Fatty acid metabolism_Homo sapiens_hsa012120.50924144
116Prion diseases_Homo sapiens_hsa050200.50219463
117Bile secretion_Homo sapiens_hsa049760.48653661
118Insulin signaling pathway_Homo sapiens_hsa049100.47937101
119Circadian rhythm_Homo sapiens_hsa047100.47339602
120Lysosome_Homo sapiens_hsa041420.45849929
121Ras signaling pathway_Homo sapiens_hsa040140.45290907
122Fructose and mannose metabolism_Homo sapiens_hsa000510.45010092
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.44951371
124Vitamin B6 metabolism_Homo sapiens_hsa007500.44745240
125Phenylalanine metabolism_Homo sapiens_hsa003600.44224553
126Rap1 signaling pathway_Homo sapiens_hsa040150.43653070
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43377493
128Rheumatoid arthritis_Homo sapiens_hsa053230.41750586
129Inositol phosphate metabolism_Homo sapiens_hsa005620.41672687
130Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41534664
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.41310764
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41146363
133Non-small cell lung cancer_Homo sapiens_hsa052230.41011161
134Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40900165
135Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38951504
136Endometrial cancer_Homo sapiens_hsa052130.37439682
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.36052757
138Carbon metabolism_Homo sapiens_hsa012000.35926255
139Wnt signaling pathway_Homo sapiens_hsa043100.35505527
140Platelet activation_Homo sapiens_hsa046110.34565151
141Alzheimers disease_Homo sapiens_hsa050100.32408874
142Allograft rejection_Homo sapiens_hsa053300.32302796
143Fatty acid biosynthesis_Homo sapiens_hsa000610.30912542
144Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28235235
145Glycerolipid metabolism_Homo sapiens_hsa005610.28127159
146Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27824693
147Renal cell carcinoma_Homo sapiens_hsa052110.27139304
148Autoimmune thyroid disease_Homo sapiens_hsa053200.26763131
149Central carbon metabolism in cancer_Homo sapiens_hsa052300.25433693
150Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.22699937
151Chemokine signaling pathway_Homo sapiens_hsa040620.21179707
152Ovarian steroidogenesis_Homo sapiens_hsa049130.20573173
153SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19705914
154Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19251949
155Hedgehog signaling pathway_Homo sapiens_hsa043400.18726356

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