C1QTNF3-AMACR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K36 demethylation (GO:0070544)5.52726652
2peptidyl-lysine dimethylation (GO:0018027)5.13474161
3histone H3-K9 demethylation (GO:0033169)4.94882162
4positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.94436481
5sperm motility (GO:0030317)4.84786783
6fusion of sperm to egg plasma membrane (GO:0007342)4.65441949
7definitive hemopoiesis (GO:0060216)4.47983624
8regulation of phosphoprotein phosphatase activity (GO:0043666)4.30567410
9acrosome reaction (GO:0007340)4.30467457
10insulin-like growth factor receptor signaling pathway (GO:0048009)4.28046420
11histone lysine demethylation (GO:0070076)4.25057963
12histone demethylation (GO:0016577)3.97943353
13cellular zinc ion homeostasis (GO:0006882)3.90499283
14stress granule assembly (GO:0034063)3.78016255
15sperm capacitation (GO:0048240)3.76482225
16protein-DNA complex disassembly (GO:0032986)3.71530066
17nucleosome disassembly (GO:0006337)3.71530066
18receptor recycling (GO:0001881)3.61011114
19iron ion import (GO:0097286)3.59175228
20protein demethylation (GO:0006482)3.54753955
21protein dealkylation (GO:0008214)3.54753955
22cranial nerve morphogenesis (GO:0021602)3.53802043
23coenzyme catabolic process (GO:0009109)3.46438603
24zinc ion homeostasis (GO:0055069)3.44282339
25carnitine shuttle (GO:0006853)3.41361349
26face development (GO:0060324)3.40947945
27retrograde transport, vesicle recycling within Golgi (GO:0000301)3.40744113
28plasma membrane fusion (GO:0045026)3.37983892
29embryonic retina morphogenesis in camera-type eye (GO:0060059)3.36630017
30multicellular organism reproduction (GO:0032504)3.33626374
31motile cilium assembly (GO:0044458)3.33125195
32cilium or flagellum-dependent cell motility (GO:0001539)3.31531109
33regulation of ARF GTPase activity (GO:0032312)3.31095642
34establishment of protein localization to Golgi (GO:0072600)3.28147207
35nuclear pore complex assembly (GO:0051292)3.27316828
36protein targeting to Golgi (GO:0000042)3.20255815
37TOR signaling (GO:0031929)3.14862246
38regulation of autophagic vacuole assembly (GO:2000785)3.14268419
39COPII vesicle coating (GO:0048208)3.14222373
40spermatid development (GO:0007286)3.02411009
41spermatid nucleus differentiation (GO:0007289)2.99291212
42carnitine transmembrane transport (GO:1902603)2.97891389
43carnitine transport (GO:0015879)2.94643356
44amino-acid betaine transport (GO:0015838)2.94643356
45reproduction (GO:0000003)2.92746766
46protein retention in ER lumen (GO:0006621)2.91503369
47phosphatidylethanolamine biosynthetic process (GO:0006646)2.90679503
48positive regulation of glycolytic process (GO:0045821)2.89605039
49myofibril assembly (GO:0030239)2.86051752
50G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.82864200
51positive regulation of CREB transcription factor activity (GO:0032793)2.81972510
52detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.81740740
53positive regulation of catecholamine secretion (GO:0033605)2.80548321
54biotin metabolic process (GO:0006768)2.77545752
55negative regulation of erythrocyte differentiation (GO:0045647)2.76837357
56maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.76413946
57regulation of histone H3-K27 methylation (GO:0061085)2.76177534
58negative regulation of JNK cascade (GO:0046329)2.68822879
59centriole assembly (GO:0098534)2.68302064
60Golgi transport vesicle coating (GO:0048200)2.67147478
61COPI coating of Golgi vesicle (GO:0048205)2.67147478
62thyroid gland development (GO:0030878)2.66629503
63diacylglycerol metabolic process (GO:0046339)2.65369199
64regulation of vacuole organization (GO:0044088)2.62902076
65cardiac myofibril assembly (GO:0055003)2.62256466
66regulation of Rab GTPase activity (GO:0032313)2.61995616
67positive regulation of Rab GTPase activity (GO:0032851)2.61995616
68response to muscle activity (GO:0014850)2.61904833
69single fertilization (GO:0007338)2.61025461
70cytoplasmic mRNA processing body assembly (GO:0033962)2.60086326
71receptor catabolic process (GO:0032801)2.59647083
72coronary vasculature morphogenesis (GO:0060977)2.59147574
73histone lysine methylation (GO:0034968)2.58952054
74phosphatidylethanolamine metabolic process (GO:0046337)2.56754938
75quaternary ammonium group transport (GO:0015697)2.55472342
76negative regulation of fatty acid biosynthetic process (GO:0045717)2.53961608
77nucleus organization (GO:0006997)2.53452025
78Golgi to endosome transport (GO:0006895)2.52989924
79androgen biosynthetic process (GO:0006702)2.50023909
80sperm-egg recognition (GO:0035036)2.49936133
81melanin metabolic process (GO:0006582)2.49462846
82regulation of ARF protein signal transduction (GO:0032012)2.48478948
83cardiac muscle hypertrophy (GO:0003300)2.46687346
84striated muscle hypertrophy (GO:0014897)2.46161135
85cardiac muscle hypertrophy in response to stress (GO:0014898)2.45616580
86muscle hypertrophy in response to stress (GO:0003299)2.45616580
87cardiac muscle adaptation (GO:0014887)2.45616580
88binding of sperm to zona pellucida (GO:0007339)2.45477615
89fatty acid transmembrane transport (GO:1902001)2.44822398
90axonemal dynein complex assembly (GO:0070286)2.44406212
91regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.40897693
92histone H3-K9 methylation (GO:0051567)2.40544618
93negative regulation of stress-activated protein kinase signaling cascade (GO:0070303)2.39912908
94negative regulation of stress-activated MAPK cascade (GO:0032873)2.39912908
95protein localization to synapse (GO:0035418)2.39889362
96melanin biosynthetic process (GO:0042438)2.38926205
97sexual reproduction (GO:0019953)2.38383429
98histone H3-K9 modification (GO:0061647)2.38125372
99regulation of nucleobase-containing compound transport (GO:0032239)2.36672520
100ribosome assembly (GO:0042255)2.35569692

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.71648914
2ESR1_20079471_ChIP-ChIP_T-47D_Human3.62415614
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.60605535
4AR_21572438_ChIP-Seq_LNCaP_Human3.24943221
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.56873660
6IGF1R_20145208_ChIP-Seq_DFB_Human2.35386823
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.30586716
8KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.26735658
9KDM2B_26808549_Chip-Seq_DND41_Human2.25556158
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.21654892
11FOXA2_19822575_ChIP-Seq_HepG2_Human2.18998815
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.10685331
13SMC4_20622854_ChIP-Seq_HELA_Human2.06580082
14PKCTHETA_26484144_Chip-Seq_BREAST_Human2.03589470
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.03185910
16CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.00817402
17KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.99443248
18MYC_22102868_ChIP-Seq_BL_Human1.95779992
19VDR_21846776_ChIP-Seq_THP-1_Human1.92099658
20ESR1_15608294_ChIP-ChIP_MCF-7_Human1.84206065
21TCF7_22412390_ChIP-Seq_EML_Mouse1.83167259
22CHD1_26751641_Chip-Seq_LNCaP_Human1.81368853
23LXR_22292898_ChIP-Seq_THP-1_Human1.80706793
24VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.78054608
25E2F7_22180533_ChIP-Seq_HELA_Human1.77061271
26RUNX1_27514584_Chip-Seq_MCF-7_Human1.71217975
27ARNT_22903824_ChIP-Seq_MCF-7_Human1.66614490
28SPI1_23127762_ChIP-Seq_K562_Human1.65468758
29AHR_22903824_ChIP-Seq_MCF-7_Human1.65144883
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.63193000
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62620660
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60482886
33CREB1_26743006_Chip-Seq_LNCaP_Human1.60290103
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59089354
35ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.56790189
36ER_23166858_ChIP-Seq_MCF-7_Human1.55026873
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.52119729
38CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.48410585
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47972107
40SCL_19346495_ChIP-Seq_HPC-7_Human1.46684722
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46242940
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42344494
43ZNF263_19887448_ChIP-Seq_K562_Human1.41720634
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41071265
45DROSHA_22980978_ChIP-Seq_HELA_Human1.40965874
46SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40059891
47FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.36316400
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.35211442
49KDM2B_26808549_Chip-Seq_JURKAT_Human1.33427175
50MYB_26560356_Chip-Seq_TH1_Human1.33147485
51KDM2B_26808549_Chip-Seq_K562_Human1.32412544
52MAF_26560356_Chip-Seq_TH2_Human1.32228692
53GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31349595
54CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28861365
55LXR_22158963_ChIP-Seq_LIVER_Mouse1.28030161
56WDR5_24793694_ChIP-Seq_LNCAP_Human1.27406170
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24584717
58RXR_22158963_ChIP-Seq_LIVER_Mouse1.24280660
59CTCF_27219007_Chip-Seq_Bcells_Human1.23864996
60ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23737367
61FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.23219283
62UTX_26944678_Chip-Seq_JUKART_Human1.22925858
63RAC3_21632823_ChIP-Seq_H3396_Human1.21830067
64VDR_24763502_ChIP-Seq_THP-1_Human1.20436807
65CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20243797
66EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19675897
67MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.19663884
68RACK7_27058665_Chip-Seq_MCF-7_Human1.16946160
69CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15668981
70TCF4_18268006_ChIP-ChIP_LS174T_Human1.13860307
71KDM5A_27292631_Chip-Seq_BREAST_Human1.11825239
72HNF4A_19822575_ChIP-Seq_HepG2_Human1.11639254
73GATA1_19941827_ChIP-Seq_MEL_Mouse1.11377868
74CIITA_25753668_ChIP-Seq_RAJI_Human1.10729334
75DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10108587
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08053313
77GATA2_19941826_ChIP-Seq_K562_Human1.07186561
78IRF8_22096565_ChIP-ChIP_GC-B_Human1.06313161
79E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04479624
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04271328
81ESR2_21235772_ChIP-Seq_MCF-7_Human1.03640625
82E2F1_17053090_ChIP-ChIP_MCF-7_Human1.03451007
83RUNX_20019798_ChIP-Seq_JUKART_Human1.02790095
84TP63_22573176_ChIP-Seq_HFKS_Human1.02303792
85MITF_21258399_ChIP-Seq_MELANOMA_Human1.01402904
86ELK3_25401928_ChIP-Seq_HUVEC_Human1.00956279
87PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00072272
88ERA_21632823_ChIP-Seq_H3396_Human0.98909645
89NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98746855
90CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98438445
91NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98081279
92GATA6_25053715_ChIP-Seq_YYC3_Human0.97718188
93CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97108261
94CTCF_21964334_ChIP-Seq_BJAB-B_Human0.96593590
95RXR_22108803_ChIP-Seq_LS180_Human0.95953843
96SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95782177
97GATA1_22025678_ChIP-Seq_K562_Human0.94673549
98P68_20966046_ChIP-Seq_HELA_Human0.94099702
99MAF_26560356_Chip-Seq_TH1_Human0.93476848
100GATA1_19941826_ChIP-Seq_K562_Human0.92967612

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy7.89320192
2MP0005410_abnormal_fertilization3.78493585
3MP0005451_abnormal_body_composition3.42136997
4MP0002009_preneoplasia3.03442991
5MP0004233_abnormal_muscle_weight2.76904473
6MP0008057_abnormal_DNA_replication2.67400353
7MP0002132_abnormal_respiratory_system2.56210925
8MP0005409_darkened_coat_color2.55169500
9MP0002249_abnormal_larynx_morphology2.40297963
10MP0004381_abnormal_hair_follicle2.36976276
11MP0003123_paternal_imprinting2.18322772
12MP0003315_abnormal_perineum_morphology2.15831066
13MP0004084_abnormal_cardiac_muscle1.98380781
14MP0003172_abnormal_lysosome_physiology1.94671638
15MP0004036_abnormal_muscle_relaxation1.93013458
16MP0003763_abnormal_thymus_physiology1.74144368
17MP0002166_altered_tumor_susceptibility1.73216854
18MP0008004_abnormal_stomach_pH1.72423847
19MP0003698_abnormal_male_reproductive1.72145687
20MP0005058_abnormal_lysosome_morphology1.60961562
21MP0004264_abnormal_extraembryonic_tissu1.55074933
22MP0003868_abnormal_feces_composition1.54758639
23MP0001929_abnormal_gametogenesis1.53377728
24MP0005670_abnormal_white_adipose1.51603454
25MP0002108_abnormal_muscle_morphology1.49457873
26MP0009697_abnormal_copulation1.48108048
27MP0005408_hypopigmentation1.47414103
28MP0005248_abnormal_Harderian_gland1.43611170
29MP0000747_muscle_weakness1.42414473
30MP0005360_urolithiasis1.40599955
31MP0005666_abnormal_adipose_tissue1.40362598
32MP0009780_abnormal_chondrocyte_physiolo1.39195057
33MP0002638_abnormal_pupillary_reflex1.38384783
34MP0001661_extended_life_span1.35985224
35MP0005499_abnormal_olfactory_system1.31574154
36MP0005394_taste/olfaction_phenotype1.31574154
37MP0000749_muscle_degeneration1.29687169
38MP0009115_abnormal_fat_cell1.29526558
39MP0002160_abnormal_reproductive_system1.29418304
40MP0005377_hearing/vestibular/ear_phenot1.28964803
41MP0003878_abnormal_ear_physiology1.28964803
42MP0002269_muscular_atrophy1.24089734
43MP0000015_abnormal_ear_pigmentation1.19543080
44MP0001270_distended_abdomen1.17665258
45MP0004858_abnormal_nervous_system1.16030958
46MP0003656_abnormal_erythrocyte_physiolo1.07260774
47MP0002396_abnormal_hematopoietic_system1.07049802
48MP0000003_abnormal_adipose_tissue1.04429661
49MP0005375_adipose_tissue_phenotype1.03565544
50MP0003045_fibrosis1.02716128
51MP0000759_abnormal_skeletal_muscle1.00251091
52MP0003136_yellow_coat_color0.99067038
53MP0003879_abnormal_hair_cell0.97137977
54MP0008007_abnormal_cellular_replicative0.96144233
55MP0003385_abnormal_body_wall0.95932298
56MP0004087_abnormal_muscle_fiber0.95840638
57MP0005085_abnormal_gallbladder_physiolo0.93809437
58MP0002161_abnormal_fertility/fecundity0.91042947
59MP0003183_abnormal_peptide_metabolism0.90028773
60MP0002970_abnormal_white_adipose0.86394481
61MP0004085_abnormal_heartbeat0.86111299
62MP0002971_abnormal_brown_adipose0.85478568
63MP0005220_abnormal_exocrine_pancreas0.84842873
64MP0010329_abnormal_lipoprotein_level0.82928669
65MP0010630_abnormal_cardiac_muscle0.82608797
66MP0001502_abnormal_circadian_rhythm0.82288333
67MP0003122_maternal_imprinting0.81283742
68MP0003191_abnormal_cellular_cholesterol0.81276662
69MP0006138_congestive_heart_failure0.80669073
70MP0004134_abnormal_chest_morphology0.79701845
71MP0000372_irregular_coat_pigmentation0.79143560
72MP0004808_abnormal_hematopoietic_stem0.78209939
73MP0000681_abnormal_thyroid_gland0.76837546
74MP0005397_hematopoietic_system_phenotyp0.75215063
75MP0001545_abnormal_hematopoietic_system0.75215063
76MP0001944_abnormal_pancreas_morphology0.75023538
77MP0002127_abnormal_cardiovascular_syste0.74814673
78MP0001984_abnormal_olfaction0.73818884
79MP0000733_abnormal_muscle_development0.73583524
80MP0001849_ear_inflammation0.71797986
81MP0001764_abnormal_homeostasis0.71524498
82MP0004272_abnormal_basement_membrane0.70585990
83MP0000371_diluted_coat_color0.70120870
84MP0002078_abnormal_glucose_homeostasis0.69575807
85MP0001188_hyperpigmentation0.68177563
86MP0001664_abnormal_digestion0.67133215
87MP0008961_abnormal_basal_metabolism0.65630918
88MP0008789_abnormal_olfactory_epithelium0.64183765
89MP0001145_abnormal_male_reproductive0.63550342
90MP0002089_abnormal_postnatal_growth/wei0.62557488
91MP0004145_abnormal_muscle_electrophysio0.61865858
92MP0000703_abnormal_thymus_morphology0.61702045
93MP0002184_abnormal_innervation0.60782534
94MP0005187_abnormal_penis_morphology0.60758521
95MP0001666_abnormal_nutrient_absorption0.60665940
96MP0000609_abnormal_liver_physiology0.60590445
97MP0003077_abnormal_cell_cycle0.59080350
98MP0002229_neurodegeneration0.58945709
99MP0008438_abnormal_cutaneous_collagen0.56500005
100MP0003121_genomic_imprinting0.55906897

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.26095391
2Abnormality of the columella (HP:0009929)3.79656416
3Menstrual irregularities (HP:0000858)3.74081643
4Resting tremor (HP:0002322)3.48528255
5Abnormality of the intrinsic pathway (HP:0010989)3.34501797
6Reduced antithrombin III activity (HP:0001976)3.15630264
7Thoracic kyphosis (HP:0002942)3.15523437
8Centrally nucleated skeletal muscle fibers (HP:0003687)3.03060172
9Renovascular hypertension (HP:0100817)2.97807944
10Exercise-induced myalgia (HP:0003738)2.97406262
11Sparse lateral eyebrow (HP:0005338)2.96702983
12Colitis (HP:0002583)2.94072472
13Acute hepatic failure (HP:0006554)2.90901609
14Abnormality of the thoracic spine (HP:0100711)2.88008028
15Truncal obesity (HP:0001956)2.85424975
16Abnormality of the fingertips (HP:0001211)2.83236220
17Hyporeflexia of lower limbs (HP:0002600)2.81524211
18Tubulointerstitial nephritis (HP:0001970)2.77397785
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.64143749
20Germ cell neoplasia (HP:0100728)2.62999774
21Self-mutilation (HP:0000742)2.54424875
22Abnormality of the ischium (HP:0003174)2.54075834
23Asymmetric septal hypertrophy (HP:0001670)2.52092968
24Prolonged partial thromboplastin time (HP:0003645)2.39418489
25Right ventricular cardiomyopathy (HP:0011663)2.38371962
26Postural instability (HP:0002172)2.35873163
27Heterotopia (HP:0002282)2.33667989
28Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.31487966
29Inflammation of the large intestine (HP:0002037)2.30725962
30Hypoplastic ischia (HP:0003175)2.30324910
31Dysmetric saccades (HP:0000641)2.29363524
32Bell-shaped thorax (HP:0001591)2.26343832
33Flat acetabular roof (HP:0003180)2.23641159
34Cutaneous melanoma (HP:0012056)2.22760053
35Insidious onset (HP:0003587)2.19669663
36Termporal pattern (HP:0011008)2.19669663
37Gastrointestinal inflammation (HP:0004386)2.18035546
38Joint hemorrhage (HP:0005261)2.14900997
39Obstructive sleep apnea (HP:0002870)2.11316449
40Hyperkalemia (HP:0002153)2.06590026
41Deep palmar crease (HP:0006191)2.04939766
42Hyperacusis (HP:0010780)2.03637630
43Gingival bleeding (HP:0000225)2.02729276
44Rhabdomyolysis (HP:0003201)2.00875823
45Bilateral sensorineural hearing impairment (HP:0008619)1.98938448
46Acute myeloid leukemia (HP:0004808)1.97506357
47Asymmetry of the thorax (HP:0001555)1.97269671
48Myoglobinuria (HP:0002913)1.96233663
49Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.94785161
50Hypoalphalipoproteinemia (HP:0003233)1.94375364
51Testicular neoplasm (HP:0010788)1.92398785
52Precocious puberty (HP:0000826)1.90865954
53Sudden death (HP:0001699)1.90765618
54Anteriorly placed anus (HP:0001545)1.90698142
55Obsessive-compulsive behavior (HP:0000722)1.88850951
56Hypercholesterolemia (HP:0003124)1.87226783
57Ankyloglossia (HP:0010296)1.84212027
58Hypolipoproteinemia (HP:0010981)1.83623634
59Abnormality of the pubic bones (HP:0003172)1.83447096
60Blue irides (HP:0000635)1.83144935
61Enlarged kidneys (HP:0000105)1.82696701
62Fatigue (HP:0012378)1.81976339
63Abnormality of the common coagulation pathway (HP:0010990)1.79643645
64Epiphyseal dysplasia (HP:0002656)1.79460151
65Dynein arm defect of respiratory motile cilia (HP:0012255)1.78723310
66Absent/shortened dynein arms (HP:0200106)1.78723310
67Hypoplasia of the thymus (HP:0000778)1.77481954
68Tapered finger (HP:0001182)1.77133788
69Lower limb hyperreflexia (HP:0002395)1.76742053
70Broad nasal tip (HP:0000455)1.76319858
71Capillary hemangiomas (HP:0005306)1.76106348
72Sensory axonal neuropathy (HP:0003390)1.74602564
73Hepatitis (HP:0012115)1.74546199
74Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.74331556
75Severe short stature (HP:0003510)1.73321783
76Flared iliac wings (HP:0002869)1.72104225
77Ventricular fibrillation (HP:0001663)1.71563037
78Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.67275076
79Abnormal tarsal ossification (HP:0008369)1.66986997
80Poikiloderma (HP:0001029)1.66457850
81Hemorrhage of the eye (HP:0011885)1.65762966
82Hypobetalipoproteinemia (HP:0003563)1.65060568
83Calf muscle hypertrophy (HP:0008981)1.64734311
84Acute lymphatic leukemia (HP:0006721)1.64655095
85Urinary urgency (HP:0000012)1.63619789
86Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.63146397
87Hypoparathyroidism (HP:0000829)1.62052671
88Macroorchidism (HP:0000053)1.59060175
89Aplasia/Hypoplasia of the earlobes (HP:0009906)1.57948010
90Infertility (HP:0000789)1.57912224
91Open mouth (HP:0000194)1.57457985
92Seborrheic dermatitis (HP:0001051)1.57209016
93Difficulty running (HP:0009046)1.57036075
94Abnormality of the lumbar spine (HP:0100712)1.56702109
95Underdeveloped nasal alae (HP:0000430)1.55248203
96Ketoacidosis (HP:0001993)1.55056904
97Distal lower limb amyotrophy (HP:0008944)1.54808263
98Prominent nose (HP:0000448)1.54762659
99Acanthocytosis (HP:0001927)1.52444342
100Truncal ataxia (HP:0002078)1.50453443

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK15.27494126
2ICK3.64056962
3AKT33.62399126
4CDK123.39765926
5MARK33.18047358
6TRIB33.09907627
7PRKD32.93488378
8EEF2K2.71310840
9LATS12.25597209
10PKN22.01019902
11OBSCN1.93159192
12FGFR41.84955747
13BRD41.84643724
14CAMK1G1.78123272
15MAP3K101.73290454
16SIK21.68485561
17TNK21.65390995
18CDK31.60482230
19CAMK1D1.58557702
20PLK41.55206707
21FGFR31.54044647
22PRPF4B1.46423853
23CSNK1A1L1.45378069
24RET1.34588903
25MAP2K71.34455582
26SIK11.31131172
27MAP3K21.30438976
28NEK21.27743061
29SGK2231.22769575
30SGK4941.22769575
31SCYL21.20152018
32STK381.18003690
33MTOR1.17142858
34MAPK111.16699382
35NME21.10289381
36SGK21.09494628
37RIPK11.06292292
38MAP3K131.05220673
39CSNK1G31.03054012
40PDPK11.02965542
41WNK11.00859170
42BLK0.96118317
43MARK20.94160960
44PDK10.93810556
45DDR20.93164041
46KSR20.92124981
47CAMKK10.91324784
48INSRR0.90595285
49SGK30.89757473
50STK38L0.87983274
51LMTK20.87053032
52RPS6KB10.86731679
53NLK0.84827248
54EPHB10.81732933
55MAP3K10.81416305
56TESK10.76241825
57LATS20.75316203
58CSNK1G10.74713579
59MAPK120.72967002
60SIK30.71813240
61PRKAA10.70975875
62ZAP700.67904137
63FGFR20.66973614
64PIK3CG0.66151264
65CDK70.65094913
66CSNK1G20.60698086
67ERN10.60544971
68MST1R0.55593824
69BTK0.55506285
70IRAK20.54491576
71MAP3K70.53509945
72PRKAA20.51832066
73CDC42BPA0.49214665
74EPHA30.49177770
75RPS6KB20.47610812
76CAMK40.47221962
77PASK0.46562851
78EIF2AK10.40842322
79ATM0.40008399
80HIPK20.38672354
81EIF2AK30.38622447
82GRK60.37295262
83MAPK100.36656382
84SYK0.36254466
85GSK3B0.34953732
86TRPM70.34791908
87NEK60.33557482
88PDGFRA0.30892667
89CDK20.29851842
90ATR0.29592849
91SGK10.27565274
92TYRO30.27482248
93PHKG20.27315560
94PHKG10.27315560
95MAPK10.26161647
96MAP3K60.24765224
97NEK90.24009382
98BRSK10.24000186
99MYLK0.23465647
100FRK0.22764775

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.37200841
2Non-small cell lung cancer_Homo sapiens_hsa052232.13329517
3Arginine biosynthesis_Homo sapiens_hsa002202.11956011
4Endometrial cancer_Homo sapiens_hsa052132.06172828
5mTOR signaling pathway_Homo sapiens_hsa041501.85166874
6Fatty acid biosynthesis_Homo sapiens_hsa000611.80864974
7Phosphatidylinositol signaling system_Homo sapiens_hsa040701.80832863
8Acute myeloid leukemia_Homo sapiens_hsa052211.78750479
9Phenylalanine metabolism_Homo sapiens_hsa003601.76514645
10Glucagon signaling pathway_Homo sapiens_hsa049221.70958914
11Lysine degradation_Homo sapiens_hsa003101.69506974
12Circadian rhythm_Homo sapiens_hsa047101.56859027
13Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.56310017
14Thyroid hormone signaling pathway_Homo sapiens_hsa049191.40539008
15Insulin signaling pathway_Homo sapiens_hsa049101.40086860
16Renin secretion_Homo sapiens_hsa049241.39254783
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.31338131
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31036594
19Insulin resistance_Homo sapiens_hsa049311.28763161
20cGMP-PKG signaling pathway_Homo sapiens_hsa040221.28425252
21Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.28232582
22Longevity regulating pathway - mammal_Homo sapiens_hsa042111.27426687
23Glioma_Homo sapiens_hsa052141.26592133
24Butanoate metabolism_Homo sapiens_hsa006501.25822572
25Inositol phosphate metabolism_Homo sapiens_hsa005621.25478636
26Long-term potentiation_Homo sapiens_hsa047201.24457229
27Prostate cancer_Homo sapiens_hsa052151.24066924
28Choline metabolism in cancer_Homo sapiens_hsa052311.21638008
29Complement and coagulation cascades_Homo sapiens_hsa046101.19506459
30B cell receptor signaling pathway_Homo sapiens_hsa046621.18139424
31Type II diabetes mellitus_Homo sapiens_hsa049301.17862256
32Other glycan degradation_Homo sapiens_hsa005111.16133183
33Chronic myeloid leukemia_Homo sapiens_hsa052201.14304957
34Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10567513
35Gap junction_Homo sapiens_hsa045401.10353914
36Estrogen signaling pathway_Homo sapiens_hsa049151.09662661
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05684411
38Thyroid cancer_Homo sapiens_hsa052161.04545087
39N-Glycan biosynthesis_Homo sapiens_hsa005101.04094257
40Pancreatic cancer_Homo sapiens_hsa052121.02579194
41ABC transporters_Homo sapiens_hsa020101.00568724
42VEGF signaling pathway_Homo sapiens_hsa043700.95819045
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93254612
44Tyrosine metabolism_Homo sapiens_hsa003500.92565624
45ErbB signaling pathway_Homo sapiens_hsa040120.91557264
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91291722
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90584033
48Glycerophospholipid metabolism_Homo sapiens_hsa005640.89981962
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87307488
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86992655
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.86922847
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86389096
53AMPK signaling pathway_Homo sapiens_hsa041520.86308118
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85618182
55Oxytocin signaling pathway_Homo sapiens_hsa049210.84149631
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79035277
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77862674
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.77429595
59Cholinergic synapse_Homo sapiens_hsa047250.77224653
60Fatty acid metabolism_Homo sapiens_hsa012120.76635792
61Salivary secretion_Homo sapiens_hsa049700.76078486
62FoxO signaling pathway_Homo sapiens_hsa040680.74772541
63mRNA surveillance pathway_Homo sapiens_hsa030150.74467215
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72798330
65Colorectal cancer_Homo sapiens_hsa052100.72414495
66Apoptosis_Homo sapiens_hsa042100.71985385
67GnRH signaling pathway_Homo sapiens_hsa049120.71335533
68Hedgehog signaling pathway_Homo sapiens_hsa043400.70638972
69Prolactin signaling pathway_Homo sapiens_hsa049170.67692727
70Alcoholism_Homo sapiens_hsa050340.67346797
71T cell receptor signaling pathway_Homo sapiens_hsa046600.66704690
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66575161
73Gastric acid secretion_Homo sapiens_hsa049710.66419986
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65259057
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.65074408
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64435989
77Hepatitis B_Homo sapiens_hsa051610.63738781
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.63349782
79Platelet activation_Homo sapiens_hsa046110.63296391
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62979601
81Melanogenesis_Homo sapiens_hsa049160.62543268
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61264650
83PPAR signaling pathway_Homo sapiens_hsa033200.60549284
84Biosynthesis of amino acids_Homo sapiens_hsa012300.60192110
85Bile secretion_Homo sapiens_hsa049760.59870215
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.57149615
87Renal cell carcinoma_Homo sapiens_hsa052110.56976123
88Pentose phosphate pathway_Homo sapiens_hsa000300.56229649
89Amphetamine addiction_Homo sapiens_hsa050310.53958762
90Circadian entrainment_Homo sapiens_hsa047130.53466782
91HIF-1 signaling pathway_Homo sapiens_hsa040660.53123865
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52403123
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.51871914
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50481614
95Insulin secretion_Homo sapiens_hsa049110.47137805
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.45926860
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44623304
98Fatty acid degradation_Homo sapiens_hsa000710.44076944
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43535241
100Viral carcinogenesis_Homo sapiens_hsa052030.43461320

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