C1QL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sodium ion export (GO:0071436)6.26686519
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.40703943
3ionotropic glutamate receptor signaling pathway (GO:0035235)5.38941940
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.35517583
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.21247167
6vocalization behavior (GO:0071625)5.16062198
7neuron cell-cell adhesion (GO:0007158)5.06714868
8protein localization to synapse (GO:0035418)5.02499112
9glutamate receptor signaling pathway (GO:0007215)5.01957174
10locomotory exploration behavior (GO:0035641)4.88266683
11regulation of glutamate receptor signaling pathway (GO:1900449)4.80880503
12synaptic vesicle exocytosis (GO:0016079)4.79598782
13glutamate secretion (GO:0014047)4.70283462
14cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.68541731
15regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.67652059
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.58965618
17neuronal action potential propagation (GO:0019227)4.57442614
18neuron recognition (GO:0008038)4.46209951
19synaptic transmission, glutamatergic (GO:0035249)4.42214122
20synaptic vesicle maturation (GO:0016188)4.37893744
21presynaptic membrane assembly (GO:0097105)4.34027475
22gamma-aminobutyric acid signaling pathway (GO:0007214)4.33962571
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.33065088
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.31841449
25regulation of synaptic vesicle exocytosis (GO:2000300)4.30980196
26negative regulation of dendrite morphogenesis (GO:0050774)4.30964306
27neuron-neuron synaptic transmission (GO:0007270)4.22712390
28amino acid import (GO:0043090)4.21135527
29exploration behavior (GO:0035640)4.20750118
30regulation of neuronal synaptic plasticity (GO:0048168)4.17399384
31regulation of excitatory postsynaptic membrane potential (GO:0060079)4.14854115
32potassium ion homeostasis (GO:0055075)4.07186521
33negative regulation of synaptic transmission, GABAergic (GO:0032229)4.02704497
34presynaptic membrane organization (GO:0097090)4.02456432
35regulation of voltage-gated calcium channel activity (GO:1901385)4.00679588
36potassium ion import (GO:0010107)3.95681593
37regulation of postsynaptic membrane potential (GO:0060078)3.94625976
38cell communication by electrical coupling (GO:0010644)3.93959731
39regulation of synaptic vesicle transport (GO:1902803)3.90030720
40regulation of ARF protein signal transduction (GO:0032012)3.87566078
41axonal fasciculation (GO:0007413)3.86885951
42dendritic spine morphogenesis (GO:0060997)3.84380473
43positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.83682017
44membrane depolarization during action potential (GO:0086010)3.80365066
45G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.75908215
46long-term synaptic potentiation (GO:0060291)3.75661416
47regulation of dendritic spine morphogenesis (GO:0061001)3.75610128
48transmission of nerve impulse (GO:0019226)3.73218439
49long-term memory (GO:0007616)3.70548760
50neuromuscular process controlling balance (GO:0050885)3.69680397
51regulation of synaptic plasticity (GO:0048167)3.66849857
52synaptic vesicle docking involved in exocytosis (GO:0016081)3.63900542
53cellular sodium ion homeostasis (GO:0006883)3.63851303
54regulation of glutamate secretion (GO:0014048)3.63676828
55cerebellar Purkinje cell differentiation (GO:0021702)3.63026620
56postsynaptic membrane organization (GO:0001941)3.62498173
57positive regulation of membrane potential (GO:0045838)3.58343838
58regulation of synapse maturation (GO:0090128)3.58091806
59neurotransmitter-gated ion channel clustering (GO:0072578)3.57041757
60behavioral defense response (GO:0002209)3.55513657
61behavioral fear response (GO:0001662)3.55513657
62synaptic vesicle endocytosis (GO:0048488)3.52202249
63serotonin metabolic process (GO:0042428)3.51363075
64neuronal ion channel clustering (GO:0045161)3.49218373
65regulation of dendritic spine development (GO:0060998)3.47299367
66fear response (GO:0042596)3.43018364
67positive regulation of dendritic spine development (GO:0060999)3.42161288
68regulation of vesicle fusion (GO:0031338)3.42152346
69neuromuscular synaptic transmission (GO:0007274)3.41292787
70neurotransmitter secretion (GO:0007269)3.40777957
71cellular potassium ion homeostasis (GO:0030007)3.39407552
72response to histamine (GO:0034776)3.37486417
73positive regulation of synapse maturation (GO:0090129)3.36725453
74positive regulation of neurotransmitter secretion (GO:0001956)3.35186104
75layer formation in cerebral cortex (GO:0021819)3.33137278
76cell communication involved in cardiac conduction (GO:0086065)3.32403600
77G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.31829737
78neurotransmitter uptake (GO:0001504)3.28096459
79neuromuscular process controlling posture (GO:0050884)3.25758785
80regulation of synaptic transmission, glutamatergic (GO:0051966)3.24421626
81positive regulation of dendritic spine morphogenesis (GO:0061003)3.22821932
82negative regulation of neurotransmitter transport (GO:0051589)3.22021905
83dendritic spine organization (GO:0097061)3.21928552
84regulation of neurotransmitter secretion (GO:0046928)3.18972284
85acid secretion (GO:0046717)3.18706962
86vesicle docking involved in exocytosis (GO:0006904)3.17122501
87membrane depolarization (GO:0051899)3.15713321
88acidic amino acid transport (GO:0015800)3.13279310
89regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.12927739
90negative regulation of amino acid transport (GO:0051956)3.12092270
91cell differentiation in hindbrain (GO:0021533)3.12071820
92neurotransmitter transport (GO:0006836)3.11118941
93L-amino acid import (GO:0043092)3.11075236
94regulation of exocytosis (GO:0017157)3.10518952
95regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.10012223
96behavioral response to cocaine (GO:0048148)3.09941449
97sleep (GO:0030431)3.08297717
98activation of protein kinase A activity (GO:0034199)3.07953326
99auditory behavior (GO:0031223)3.06641791
100synaptic vesicle transport (GO:0048489)3.06233687
101establishment of synaptic vesicle localization (GO:0097480)3.06233687
102learning (GO:0007612)3.04764091
103proline transport (GO:0015824)3.02827029
104long term synaptic depression (GO:0060292)3.02399913
105cellular potassium ion transport (GO:0071804)3.02301909
106potassium ion transmembrane transport (GO:0071805)3.02301909
107membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.00838218
108detection of calcium ion (GO:0005513)3.00171907
109innervation (GO:0060384)2.98439068
110intraspecies interaction between organisms (GO:0051703)2.98203392
111gamma-aminobutyric acid transport (GO:0015812)2.97705541
112positive regulation of synapse assembly (GO:0051965)2.97581425
113regulation of synaptic transmission (GO:0050804)2.95101649
114positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.94840766
115regulation of synapse structural plasticity (GO:0051823)2.88555906
116cerebellar granule cell differentiation (GO:0021707)2.87474977
117synaptic transmission (GO:0007268)2.87219484
118righting reflex (GO:0060013)2.86551151
119regulation of inositol phosphate biosynthetic process (GO:0010919)2.86136937
120positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.85168716
121neuron remodeling (GO:0016322)2.84243222
122regulation of neurotransmitter transport (GO:0051588)2.84007445
123cochlea development (GO:0090102)2.83733135
124positive regulation of neurotransmitter transport (GO:0051590)2.81500157
125regulation of neurotransmitter levels (GO:0001505)2.81475650
126negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.81284097
127dendrite morphogenesis (GO:0048813)2.81173886
128regulation of neuron projection regeneration (GO:0070570)2.80523993
129regulation of axon regeneration (GO:0048679)2.80523993
130mating behavior (GO:0007617)2.79740288
131negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.77975157
132chemosensory behavior (GO:0007635)2.77895132
133positive regulation of synaptic transmission (GO:0050806)2.77077689
134startle response (GO:0001964)2.76884793
135regulation of respiratory system process (GO:0044065)2.76006136

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.47636518
2GBX2_23144817_ChIP-Seq_PC3_Human4.08202880
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.16268188
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15588580
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02156183
6* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.74045223
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65636751
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65636751
9* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58913184
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58453405
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.53939382
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49592967
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.47069172
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44398315
15REST_21632747_ChIP-Seq_MESCs_Mouse2.41512259
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.37995437
17TAF15_26573619_Chip-Seq_HEK293_Human2.22581934
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15619839
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.14312014
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13947720
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.11374887
22* RNF2_27304074_Chip-Seq_ESCs_Mouse2.10290122
23DROSHA_22980978_ChIP-Seq_HELA_Human2.05808185
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01018473
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.95577022
26* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95481945
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.87667476
28AR_21572438_ChIP-Seq_LNCaP_Human1.83030662
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80520657
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75807416
31SMAD4_21799915_ChIP-Seq_A2780_Human1.74296757
32VDR_22108803_ChIP-Seq_LS180_Human1.73861780
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72624872
34RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.72612029
35* P300_19829295_ChIP-Seq_ESCs_Human1.71042188
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66101625
37FUS_26573619_Chip-Seq_HEK293_Human1.58527828
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57106880
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56571262
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55633171
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54392752
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.52251494
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50311221
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.49476484
45ZNF274_21170338_ChIP-Seq_K562_Hela1.48943619
46* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46718757
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46026270
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45324547
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45287025
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44105483
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43981490
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41691623
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.41603167
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40233145
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.39371096
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37206920
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33232269
58AR_25329375_ChIP-Seq_VCAP_Human1.32978582
59CTNNB1_20460455_ChIP-Seq_HCT116_Human1.30824327
60TP53_16413492_ChIP-PET_HCT116_Human1.30437425
61KDM2B_26808549_Chip-Seq_K562_Human1.30043886
62ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.27846020
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24130248
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23740469
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23737200
66IGF1R_20145208_ChIP-Seq_DFB_Human1.23231603
67* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23141368
68SOX2_21211035_ChIP-Seq_LN229_Gbm1.22559254
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.21846228
70STAT3_23295773_ChIP-Seq_U87_Human1.21605978
71RING1B_27294783_Chip-Seq_ESCs_Mouse1.20657207
72GATA1_26923725_Chip-Seq_HPCs_Mouse1.19695137
73DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19013935
74ER_23166858_ChIP-Seq_MCF-7_Human1.13448369
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.12747588
76TP53_18474530_ChIP-ChIP_U2OS_Human1.12033389
77TCF4_23295773_ChIP-Seq_U87_Human1.11841910
78RNF2_27304074_Chip-Seq_NSC_Mouse1.11622604
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11108375
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.10406715
81JUN_21703547_ChIP-Seq_K562_Human1.08736894
82TET1_21490601_ChIP-Seq_MESCs_Mouse1.08515903
83RUNX2_22187159_ChIP-Seq_PCA_Human1.07278933
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06731722
85* NANOG_18555785_Chip-Seq_ESCs_Mouse1.06552392
86* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06291290
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05619722
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04136717
89AR_19668381_ChIP-Seq_PC3_Human1.03742600
90EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03177018
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02394996
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02394996
93RING1B_27294783_Chip-Seq_NPCs_Mouse1.01690317
94BCAT_22108803_ChIP-Seq_LS180_Human1.00814469
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00312972
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00223429
97WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99377486
98ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99304365
99AHR_22903824_ChIP-Seq_MCF-7_Human0.98963651
100P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96953542
101GATA1_22025678_ChIP-Seq_K562_Human0.96401942
102GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95906571
103* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95395703
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93558812
105YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93486303
106RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93060844
107TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92219607
108SMAD3_21741376_ChIP-Seq_HESCs_Human0.91476201
109* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91005750
110* E2F1_18555785_Chip-Seq_ESCs_Mouse0.90170359
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89786120
112KDM2B_26808549_Chip-Seq_REH_Human0.89310308
113EGR1_19032775_ChIP-ChIP_M12_Human0.88193821
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87930594
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87201392
116ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86878161
117* P53_22387025_ChIP-Seq_ESCs_Mouse0.86370107
118VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86032937
119* CMYC_18555785_Chip-Seq_ESCs_Mouse0.86032525
120DPY_21335234_ChIP-Seq_ESCs_Mouse0.84655406
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84501933
122FLI1_27457419_Chip-Seq_LIVER_Mouse0.81065978
123STAT3_18555785_ChIP-Seq_MESCs_Mouse0.79547397
124CTCF_27219007_Chip-Seq_Bcells_Human0.78476548

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.50250864
2MP0003880_abnormal_central_pattern6.13173190
3MP0003635_abnormal_synaptic_transmissio4.08692036
4MP0004270_analgesia3.54331764
5MP0009745_abnormal_behavioral_response3.52345013
6MP0002063_abnormal_learning/memory/cond3.31956366
7MP0002064_seizures3.22638634
8MP0001968_abnormal_touch/_nociception3.10390619
9MP0002572_abnormal_emotion/affect_behav2.85111842
10MP0002272_abnormal_nervous_system2.71455906
11MP0002736_abnormal_nociception_after2.63782839
12MP0001440_abnormal_grooming_behavior2.62220995
13MP0009046_muscle_twitch2.61458412
14MP0001486_abnormal_startle_reflex2.49390686
15MP0001501_abnormal_sleep_pattern2.45395138
16MP0005423_abnormal_somatic_nervous2.43822047
17MP0002734_abnormal_mechanical_nocicepti2.32380608
18MP0002735_abnormal_chemical_nociception2.30743483
19MP0003329_amyloid_beta_deposits2.22618046
20MP0002067_abnormal_sensory_capabilities1.98988110
21MP0000778_abnormal_nervous_system1.97627155
22MP0002733_abnormal_thermal_nociception1.81190050
23MP0001970_abnormal_pain_threshold1.80719686
24MP0006276_abnormal_autonomic_nervous1.76096341
25MP0001905_abnormal_dopamine_level1.70276075
26MP0002184_abnormal_innervation1.69043522
27MP0004147_increased_porphyrin_level1.65627561
28MP0004924_abnormal_behavior1.59996545
29MP0005386_behavior/neurological_phenoty1.59996545
30MP0001529_abnormal_vocalization1.59157716
31MP0002557_abnormal_social/conspecific_i1.55773378
32MP0009780_abnormal_chondrocyte_physiolo1.53085953
33MP0003879_abnormal_hair_cell1.53016044
34MP0008569_lethality_at_weaning1.50035803
35MP0001348_abnormal_lacrimal_gland1.48575365
36MP0002837_dystrophic_cardiac_calcinosis1.44065305
37MP0004885_abnormal_endolymph1.43941069
38MP0000955_abnormal_spinal_cord1.43488202
39MP0004142_abnormal_muscle_tone1.41411208
40MP0002882_abnormal_neuron_morphology1.40583505
41MP0004858_abnormal_nervous_system1.40268038
42MP0002066_abnormal_motor_capabilities/c1.39876510
43MP0004811_abnormal_neuron_physiology1.37189783
44MP0002822_catalepsy1.35084071
45MP0000920_abnormal_myelination1.31704085
46MP0001188_hyperpigmentation1.30373813
47MP0003633_abnormal_nervous_system1.30352068
48MP0005551_abnormal_eye_electrophysiolog1.27328533
49MP0004145_abnormal_muscle_electrophysio1.27220832
50MP0004742_abnormal_vestibular_system1.25849730
51MP0005409_darkened_coat_color1.25496744
52MP0001984_abnormal_olfaction1.24579164
53MP0001502_abnormal_circadian_rhythm1.23626773
54MP0003631_nervous_system_phenotype1.18375279
55MP0005646_abnormal_pituitary_gland1.12124811
56MP0003787_abnormal_imprinting1.10689273
57MP0002909_abnormal_adrenal_gland1.09655871
58MP0005171_absent_coat_pigmentation1.08871287
59MP0002229_neurodegeneration1.07512955
60MP0002876_abnormal_thyroid_physiology1.06757279
61MP0005645_abnormal_hypothalamus_physiol1.06383887
62MP0002152_abnormal_brain_morphology1.04306910
63MP0000604_amyloidosis1.03464112
64MP0001963_abnormal_hearing_physiology1.03001402
65MP0003123_paternal_imprinting1.00438152
66MP0001986_abnormal_taste_sensitivity1.00431613
67MP0000751_myopathy0.96888346
68MP0003634_abnormal_glial_cell0.95130950
69MP0004484_altered_response_of0.94656737
70MP0003632_abnormal_nervous_system0.92813902
71MP0008874_decreased_physiological_sensi0.88335933
72MP0005535_abnormal_body_temperature0.88213252
73MP0001485_abnormal_pinna_reflex0.87662187
74MP0006292_abnormal_olfactory_placode0.87479734
75MP0002752_abnormal_somatic_nervous0.87253667
76MP0002069_abnormal_eating/drinking_beha0.86662625
77MP0003690_abnormal_glial_cell0.83536811
78MP0002638_abnormal_pupillary_reflex0.82781742
79MP0003122_maternal_imprinting0.82214375
80MP0004085_abnormal_heartbeat0.81217739
81MP0001664_abnormal_digestion0.80115251
82MP0003075_altered_response_to0.78225715
83MP0008872_abnormal_physiological_respon0.75246448
84MP0010386_abnormal_urinary_bladder0.75184033
85MP0004510_myositis0.74590033
86MP0000026_abnormal_inner_ear0.73024033
87MP0004215_abnormal_myocardial_fiber0.72442869
88MP0003172_abnormal_lysosome_physiology0.70732923
89MP0003136_yellow_coat_color0.70196589
90MP0003938_abnormal_ear_development0.68775998
91MP0009379_abnormal_foot_pigmentation0.67905126
92MP0005623_abnormal_meninges_morphology0.67878935
93MP0002102_abnormal_ear_morphology0.65819440
94MP0000631_abnormal_neuroendocrine_gland0.63743516
95MP0001177_atelectasis0.62635413
96MP0006072_abnormal_retinal_apoptosis0.62028883
97MP0002090_abnormal_vision0.61847357
98MP0004130_abnormal_muscle_cell0.60937485
99MP0005499_abnormal_olfactory_system0.60467889
100MP0005394_taste/olfaction_phenotype0.60467889
101MP0008877_abnormal_DNA_methylation0.59945657
102MP0004043_abnormal_pH_regulation0.59528829
103MP0000013_abnormal_adipose_tissue0.59304103
104MP0000681_abnormal_thyroid_gland0.57924473
105MP0005595_abnormal_vascular_smooth0.57655122
106MP0010769_abnormal_survival0.56902373
107MP0003956_abnormal_body_size0.55845684
108MP0001765_abnormal_ion_homeostasis0.55730806
109MP0001943_abnormal_respiration0.54431564
110MP0005410_abnormal_fertilization0.54189217
111MP0010768_mortality/aging0.54023984
112MP0003283_abnormal_digestive_organ0.53705783
113MP0001346_abnormal_lacrimal_gland0.53674618
114MP0002082_postnatal_lethality0.53121051
115MP0010770_preweaning_lethality0.53121051
116MP0005195_abnormal_posterior_eye0.51857785
117MP0003861_abnormal_nervous_system0.51751956
118MP0005448_abnormal_energy_balance0.51567514
119MP0003045_fibrosis0.50465263
120MP0002083_premature_death0.49321117
121MP0000747_muscle_weakness0.43886206
122MP0003137_abnormal_impulse_conducting0.42572344
123MP0003183_abnormal_peptide_metabolism0.41973675
124MP0003121_genomic_imprinting0.41140471
125MP0002928_abnormal_bile_duct0.40821323
126MP0002873_normal_phenotype0.40444485

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.97311005
2Focal seizures (HP:0007359)5.63561721
3Myokymia (HP:0002411)5.58309331
4Epileptic encephalopathy (HP:0200134)5.39283824
5Visual hallucinations (HP:0002367)5.24407520
6Atonic seizures (HP:0010819)4.76180764
7Hyperventilation (HP:0002883)4.40691048
8Absence seizures (HP:0002121)4.39086058
9Cerebral inclusion bodies (HP:0100314)4.37545526
10Obstructive sleep apnea (HP:0002870)4.36254989
11Dialeptic seizures (HP:0011146)4.25536398
12Febrile seizures (HP:0002373)4.00382311
13Neurofibrillary tangles (HP:0002185)3.95865204
14Generalized tonic-clonic seizures (HP:0002069)3.85401710
15Broad-based gait (HP:0002136)3.81210502
16Amblyopia (HP:0000646)3.64045294
17Tetraplegia (HP:0002445)3.63711474
18Progressive cerebellar ataxia (HP:0002073)3.62091235
19Supranuclear gaze palsy (HP:0000605)3.54394943
20Dysmetria (HP:0001310)3.33369440
21Annular pancreas (HP:0001734)3.29329315
22Termporal pattern (HP:0011008)3.16918742
23Insidious onset (HP:0003587)3.16918742
24Drooling (HP:0002307)3.16724110
25Excessive salivation (HP:0003781)3.16724110
26Torticollis (HP:0000473)3.10369890
27Action tremor (HP:0002345)3.05970894
28Limb dystonia (HP:0002451)3.05195148
29Poor eye contact (HP:0000817)3.00704679
30Focal dystonia (HP:0004373)3.00319419
31Degeneration of the lateral corticospinal tracts (HP:0002314)2.98531651
32Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.98531651
33Gaze-evoked nystagmus (HP:0000640)2.96667727
34Impaired vibration sensation in the lower limbs (HP:0002166)2.92118509
35Dysdiadochokinesis (HP:0002075)2.87305284
36Hemiparesis (HP:0001269)2.87188435
37Absent speech (HP:0001344)2.87136070
38Truncal ataxia (HP:0002078)2.87105080
39Abnormality of the corticospinal tract (HP:0002492)2.84671983
40Anxiety (HP:0000739)2.80655963
41Neuronal loss in central nervous system (HP:0002529)2.80203502
42Diplopia (HP:0000651)2.77211170
43Abnormality of binocular vision (HP:0011514)2.77211170
44Delusions (HP:0000746)2.74855477
45Epileptiform EEG discharges (HP:0011182)2.71183867
46Clonus (HP:0002169)2.70582136
47Cerebral hypomyelination (HP:0006808)2.64850889
48Sleep apnea (HP:0010535)2.63729115
49Craniofacial dystonia (HP:0012179)2.62331728
50Abnormal social behavior (HP:0012433)2.53750269
51Impaired social interactions (HP:0000735)2.53750269
52Choreoathetosis (HP:0001266)2.52974209
53Scanning speech (HP:0002168)2.49930015
54Depression (HP:0000716)2.48511695
55EEG with generalized epileptiform discharges (HP:0011198)2.46539361
56Generalized myoclonic seizures (HP:0002123)2.45367818
57Urinary bladder sphincter dysfunction (HP:0002839)2.44152374
58Spastic gait (HP:0002064)2.43322292
59Inability to walk (HP:0002540)2.40474656
60Abnormality of saccadic eye movements (HP:0000570)2.40063895
61Abnormal eating behavior (HP:0100738)2.38840829
62Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.37169526
63Dysmetric saccades (HP:0000641)2.31139274
64Retinal dysplasia (HP:0007973)2.27462342
65Stereotypic behavior (HP:0000733)2.25250811
66Akinesia (HP:0002304)2.25096690
67Ankle clonus (HP:0011448)2.24910912
68Rigidity (HP:0002063)2.22733838
69Intention tremor (HP:0002080)2.20595530
70Thickened helices (HP:0000391)2.20300991
71Abnormality of salivation (HP:0100755)2.20180556
72Hypsarrhythmia (HP:0002521)2.19111354
73Mutism (HP:0002300)2.17846002
74Progressive inability to walk (HP:0002505)2.17520235
75Postural instability (HP:0002172)2.17471030
76Blue irides (HP:0000635)2.15057426
77Abnormality of the lower motor neuron (HP:0002366)2.14664896
78Urinary urgency (HP:0000012)2.09444860
79Widely spaced teeth (HP:0000687)2.06874154
80Clumsiness (HP:0002312)2.06018414
81Lower limb muscle weakness (HP:0007340)2.05992697
82Dynein arm defect of respiratory motile cilia (HP:0012255)2.03399150
83Absent/shortened dynein arms (HP:0200106)2.03399150
84Type II lissencephaly (HP:0007260)2.03380313
85Impaired smooth pursuit (HP:0007772)2.02013427
86Limb ataxia (HP:0002070)2.01600916
87Psychosis (HP:0000709)2.01275175
88Bradykinesia (HP:0002067)1.99266231
89Acute necrotizing encephalopathy (HP:0006965)1.97921003
90Protruding tongue (HP:0010808)1.97105849
91Apathy (HP:0000741)1.96833910
92Spastic tetraparesis (HP:0001285)1.96695012
93Impaired vibratory sensation (HP:0002495)1.95622110
94Rapidly progressive (HP:0003678)1.95023749
95Gait imbalance (HP:0002141)1.94148717
96Ventricular fibrillation (HP:0001663)1.92472050
97Status epilepticus (HP:0002133)1.92460544
98Megalencephaly (HP:0001355)1.92344083
99Peripheral hypomyelination (HP:0007182)1.92009724
100Memory impairment (HP:0002354)1.88873465
101Lower limb asymmetry (HP:0100559)1.86969871
102Gait ataxia (HP:0002066)1.86785605
103Confusion (HP:0001289)1.85228646
104Progressive macrocephaly (HP:0004481)1.85145768
105Abnormal ciliary motility (HP:0012262)1.84112325
106Morphological abnormality of the pyramidal tract (HP:0002062)1.82719443
107CNS hypomyelination (HP:0003429)1.80988437
108Fair hair (HP:0002286)1.80621886
109Abnormality of the periventricular white matter (HP:0002518)1.80446543
110Increased circulating renin level (HP:0000848)1.79135948
111Hydroureter (HP:0000072)1.77448018
112Fetal akinesia sequence (HP:0001989)1.76514550
113Hemiplegia (HP:0002301)1.75916620
114Slow saccadic eye movements (HP:0000514)1.75637596
115Insomnia (HP:0100785)1.74099401
116Medial flaring of the eyebrow (HP:0010747)1.74097790
117Pheochromocytoma (HP:0002666)1.74001380
118Incomplete penetrance (HP:0003829)1.73758588
119Abnormality of ocular smooth pursuit (HP:0000617)1.71640267
120Abnormality of aromatic amino acid family metabolism (HP:0004338)1.71401446
121Papilledema (HP:0001085)1.70858783
122Spinal cord compression (HP:0002176)1.70608667
123Diminished motivation (HP:0000745)1.69592521
124Genetic anticipation (HP:0003743)1.69427699
125Bowel incontinence (HP:0002607)1.69263964
126Esotropia (HP:0000565)1.68954489
127Aplasia of the phalanges of the hand (HP:0009802)1.68489014
128Aplasia involving bones of the extremities (HP:0009825)1.68489014
129Aplasia involving bones of the upper limbs (HP:0009823)1.68489014
130Gastroesophageal reflux (HP:0002020)1.68272781

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.00380651
2NTRK34.90305571
3RIPK43.07513491
4MAP3K92.91306975
5MAP3K42.84950088
6CASK2.77432879
7PNCK2.59822249
8MAP2K72.46855713
9MAP3K122.40193021
10PLK22.19636663
11MINK12.10544818
12TNIK2.05210727
13KSR22.02028712
14DAPK22.01542097
15PAK61.96542892
16MAP2K41.96351233
17MARK11.90392848
18GRK51.75561612
19MAP3K131.72026690
20KSR11.68496251
21ARAF1.59905320
22FES1.59876086
23PTK2B1.58560663
24INSRR1.57700366
25PINK11.56733214
26NTRK11.56714976
27BMPR21.55520806
28FGR1.55226881
29NME11.50458865
30DAPK11.49191071
31NTRK21.48246864
32CDK51.38570829
33SIK21.33298272
34PRPF4B1.31836012
35OXSR11.31490420
36CAMK2A1.30230781
37STK391.27060597
38CDK191.26843521
39CAMK2B1.26779426
40RAF11.19284505
41PRKCG1.17438766
42MAPK131.11066128
43UHMK10.98042825
44ALK0.97518313
45PRKD30.95444400
46RIPK10.95297205
47MAP2K60.94293594
48CAMKK10.87254177
49CAMK10.86941971
50MAP3K20.86432189
51CAMK40.84459755
52GRK60.83788276
53PAK30.80738155
54STK380.80676619
55CAMK2D0.80081955
56DYRK1A0.79385099
57TYRO30.78084996
58WNK10.71459587
59CDK140.71124313
60CDK180.71055865
61CDK150.69453392
62SGK10.68311704
63FER0.66922592
64SGK20.66896571
65BCR0.65538935
66ROCK20.65449836
67MUSK0.65407832
68PRKCE0.65018983
69MAPKAPK50.64257233
70CAMK1G0.63932146
71BRSK10.63827303
72SGK30.63506413
73PKN10.63483352
74STK110.61014005
75GRK70.60742821
76CDK11A0.60570997
77WNK40.59546359
78CSNK1G20.58916053
79LATS20.58891694
80SGK2230.57838139
81SGK4940.57838139
82CAMK2G0.55383959
83PDPK10.54979726
84MARK20.54312183
85MAP3K10.52452996
86MAP3K60.51507455
87FGFR20.49616864
88RET0.49146523
89MOS0.48934492
90PRKCQ0.48242862
91FRK0.47773466
92MAPK120.46636266
93FYN0.46073304
94NEK60.45650029
95PDK10.45392237
96MAP3K70.44648685
97CCNB10.44591788
98FGFR10.44402592
99TNK20.42749899
100PHKG10.42695239
101PHKG20.42695239
102PRKD20.42500968
103DMPK0.41427561
104ADRBK20.40054876
105PRKCH0.37806935
106FGFR30.36666044
107MAP2K10.36654239
108PRKG20.35863275
109PRKCZ0.35055155
110DAPK30.35006448
111PRKACA0.34710264
112RPS6KA30.34426072
113CAMKK20.33993014
114MAPK100.33455605
115PRKG10.33405082
116RPS6KB10.32390273
117PRKCA0.32080095
118PBK0.29269685
119PRKCB0.26437451
120SYK0.25612370

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.26810156
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.02096315
3Long-term potentiation_Homo sapiens_hsa047203.00310459
4Glutamatergic synapse_Homo sapiens_hsa047242.80840978
5Synaptic vesicle cycle_Homo sapiens_hsa047212.79596838
6Circadian entrainment_Homo sapiens_hsa047132.76165536
7Amphetamine addiction_Homo sapiens_hsa050312.60381328
8GABAergic synapse_Homo sapiens_hsa047272.58325167
9Morphine addiction_Homo sapiens_hsa050322.48288411
10Olfactory transduction_Homo sapiens_hsa047402.37187145
11Salivary secretion_Homo sapiens_hsa049702.35653881
12Dopaminergic synapse_Homo sapiens_hsa047282.13200818
13Collecting duct acid secretion_Homo sapiens_hsa049661.97229144
14Long-term depression_Homo sapiens_hsa047301.96836588
15Taste transduction_Homo sapiens_hsa047421.94790854
16Renin secretion_Homo sapiens_hsa049241.93323229
17Serotonergic synapse_Homo sapiens_hsa047261.92803611
18Gastric acid secretion_Homo sapiens_hsa049711.91223961
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90108302
20Calcium signaling pathway_Homo sapiens_hsa040201.79253306
21Insulin secretion_Homo sapiens_hsa049111.77187747
22Oxytocin signaling pathway_Homo sapiens_hsa049211.70849998
23Cholinergic synapse_Homo sapiens_hsa047251.69895363
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68819250
25Oxidative phosphorylation_Homo sapiens_hsa001901.65185946
26Alzheimers disease_Homo sapiens_hsa050101.49272903
27Phototransduction_Homo sapiens_hsa047441.47490116
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.46407475
29GnRH signaling pathway_Homo sapiens_hsa049121.45754667
30Cardiac muscle contraction_Homo sapiens_hsa042601.43535060
31Cocaine addiction_Homo sapiens_hsa050301.39347466
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36085826
33Axon guidance_Homo sapiens_hsa043601.31782013
34Vitamin B6 metabolism_Homo sapiens_hsa007501.30637824
35cAMP signaling pathway_Homo sapiens_hsa040241.23621413
36Gap junction_Homo sapiens_hsa045401.20315281
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19737555
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16805375
39Vibrio cholerae infection_Homo sapiens_hsa051101.14221917
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12382728
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09084043
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07235019
43Parkinsons disease_Homo sapiens_hsa050121.06820339
44Vascular smooth muscle contraction_Homo sapiens_hsa042701.05322087
45Estrogen signaling pathway_Homo sapiens_hsa049151.04962915
46Melanogenesis_Homo sapiens_hsa049161.04690368
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02919514
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02294751
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99729481
50Glioma_Homo sapiens_hsa052140.97671378
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92186824
52Pancreatic secretion_Homo sapiens_hsa049720.90716963
53ErbB signaling pathway_Homo sapiens_hsa040120.88988343
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87369108
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86422642
56Dorso-ventral axis formation_Homo sapiens_hsa043200.85272504
57Huntingtons disease_Homo sapiens_hsa050160.82877717
58Type II diabetes mellitus_Homo sapiens_hsa049300.81492450
59Choline metabolism in cancer_Homo sapiens_hsa052310.78912860
60mTOR signaling pathway_Homo sapiens_hsa041500.78089710
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.73677360
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70528530
63Oocyte meiosis_Homo sapiens_hsa041140.68047695
64Thyroid hormone synthesis_Homo sapiens_hsa049180.66950483
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66555602
66VEGF signaling pathway_Homo sapiens_hsa043700.66474286
67African trypanosomiasis_Homo sapiens_hsa051430.66425286
68Arginine biosynthesis_Homo sapiens_hsa002200.60969173
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60655266
70Dilated cardiomyopathy_Homo sapiens_hsa054140.60510281
71MAPK signaling pathway_Homo sapiens_hsa040100.59932056
72Ras signaling pathway_Homo sapiens_hsa040140.58813248
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56438990
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54933690
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54733660
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.54565201
77Glucagon signaling pathway_Homo sapiens_hsa049220.50821543
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47493040
79Prion diseases_Homo sapiens_hsa050200.45794585
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45789790
81Rheumatoid arthritis_Homo sapiens_hsa053230.45567724
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45500066
83Rap1 signaling pathway_Homo sapiens_hsa040150.43166986
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42215575
85Wnt signaling pathway_Homo sapiens_hsa043100.40736701
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38326325
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37000930
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36776422
89Renal cell carcinoma_Homo sapiens_hsa052110.36676694
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36159363
91Inositol phosphate metabolism_Homo sapiens_hsa005620.34142975
92Ether lipid metabolism_Homo sapiens_hsa005650.33792112
93Alcoholism_Homo sapiens_hsa050340.33515114
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33425539
95Fatty acid biosynthesis_Homo sapiens_hsa000610.30326735
96Bile secretion_Homo sapiens_hsa049760.29817373
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29551951
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.28781649
99Platelet activation_Homo sapiens_hsa046110.28143048
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27000689
101Circadian rhythm_Homo sapiens_hsa047100.26106329
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24581794
103Mineral absorption_Homo sapiens_hsa049780.24245817
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24011693
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22107918
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22097394
107Endocytosis_Homo sapiens_hsa041440.19720255
108Ovarian steroidogenesis_Homo sapiens_hsa049130.19628820
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.19464797
110Chemokine signaling pathway_Homo sapiens_hsa040620.19366839
111HIF-1 signaling pathway_Homo sapiens_hsa040660.19143412
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.18937337
113B cell receptor signaling pathway_Homo sapiens_hsa046620.17564144
114Insulin signaling pathway_Homo sapiens_hsa049100.16743150
115Nitrogen metabolism_Homo sapiens_hsa009100.16000667
116Regulation of autophagy_Homo sapiens_hsa041400.14811519
117Non-small cell lung cancer_Homo sapiens_hsa052230.14183180

Most similar genes based on co-expression Upload to Enrichr

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