C1QB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the B-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.46164046
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.46164046
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.46164046
4modulation by symbiont of host immune response (GO:0052553)6.46164046
5positive regulation by symbiont of host defense response (GO:0052509)6.46164046
6modulation by symbiont of host defense response (GO:0052031)6.46164046
7microglial cell activation (GO:0001774)6.18648751
8regulation of interferon-beta biosynthetic process (GO:0045357)6.16574139
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.76107324
10macrophage activation involved in immune response (GO:0002281)5.62561858
11neutrophil activation involved in immune response (GO:0002283)5.07316586
12positive regulation of interferon-alpha production (GO:0032727)5.00960314
13macrophage activation (GO:0042116)4.82677388
14positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.81213275
15regulation of interferon-alpha production (GO:0032647)4.74980571
16response to peptidoglycan (GO:0032494)4.70939457
17negative regulation of granulocyte differentiation (GO:0030853)4.67887146
18immunoglobulin mediated immune response (GO:0016064)4.63151376
19positive regulation of antigen processing and presentation (GO:0002579)4.44653851
20regulation of mononuclear cell migration (GO:0071675)4.37648509
21G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.29240780
22positive regulation of myeloid leukocyte mediated immunity (GO:0002888)4.28215424
23regulation of hypersensitivity (GO:0002883)4.28059268
24* complement activation, classical pathway (GO:0006958)4.25509304
25regulation of macrophage chemotaxis (GO:0010758)4.23052021
26regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.15933504
27respiratory burst (GO:0045730)4.13257567
28regulation of B cell receptor signaling pathway (GO:0050855)4.08305123
29response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.07870822
30response to host immune response (GO:0052572)4.07870822
31production of molecular mediator involved in inflammatory response (GO:0002532)4.05680218
32pinocytosis (GO:0006907)3.94510438
33myeloid cell activation involved in immune response (GO:0002275)3.92756423
34* complement activation (GO:0006956)3.92237460
35positive regulation of monocyte chemotaxis (GO:0090026)3.83577391
36positive regulation of cellular amide metabolic process (GO:0034250)3.83070786
37regulation of apoptotic cell clearance (GO:2000425)3.82155205
38adhesion of symbiont to host cell (GO:0044650)3.82057277
39virion attachment to host cell (GO:0019062)3.82057277
40response to host defenses (GO:0052200)3.77776850
41response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.77776850
42response to host (GO:0075136)3.77776850
43cellular extravasation (GO:0045123)3.76222176
44regulation of antigen processing and presentation (GO:0002577)3.74669508
45positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.69001909
46positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.59268332
47positive regulation of chemokine secretion (GO:0090197)3.51800805
48adhesion of symbiont to host (GO:0044406)3.45607117
49regulation of dendritic cell antigen processing and presentation (GO:0002604)3.45195225
50positive regulation of interferon-beta production (GO:0032728)3.44735985
51phagocytosis, engulfment (GO:0006911)3.41621970
52I-kappaB phosphorylation (GO:0007252)3.41156194
53lipopolysaccharide-mediated signaling pathway (GO:0031663)3.40460792
54lymphocyte chemotaxis (GO:0048247)3.39879567
55glycolipid catabolic process (GO:0019377)3.39690758
56purinergic nucleotide receptor signaling pathway (GO:0035590)3.38134067
57regulation of interleukin-8 biosynthetic process (GO:0045414)3.37397170
58lipoxygenase pathway (GO:0019372)3.36587496
59detection of molecule of bacterial origin (GO:0032490)3.34726481
60adenosine receptor signaling pathway (GO:0001973)3.34692828
61hyaluronan catabolic process (GO:0030214)3.31291765
62granulocyte activation (GO:0036230)3.29282137
63mannose metabolic process (GO:0006013)3.28887422
64detection of external biotic stimulus (GO:0098581)3.26335229
65positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.26259928
66response to muramyl dipeptide (GO:0032495)3.22539274
67regulation of monocyte chemotaxis (GO:0090025)3.21577974
68neutrophil activation (GO:0042119)3.20564158
69positive regulation of B cell differentiation (GO:0045579)3.20417245
70regulation of myeloid leukocyte mediated immunity (GO:0002886)3.20355230
71positive regulation of macrophage cytokine production (GO:0060907)3.20142146
72detection of other organism (GO:0098543)3.19562211
73apoptotic cell clearance (GO:0043277)3.19499981
74negative regulation of interleukin-6 production (GO:0032715)3.18241582
75myeloid leukocyte activation (GO:0002274)3.17376827
76positive regulation of mast cell activation (GO:0033005)3.16577425
77amino sugar catabolic process (GO:0046348)3.15836815
78B cell mediated immunity (GO:0019724)3.14868945
79positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.13643841
80detection of bacterium (GO:0016045)3.10407483
81positive regulation of mast cell activation involved in immune response (GO:0033008)3.09605131
82positive regulation of mast cell degranulation (GO:0043306)3.09605131
83* protein activation cascade (GO:0072376)3.07855370
84regulation of mast cell degranulation (GO:0043304)3.07513612
85eosinophil migration (GO:0072677)3.05930976
86positive regulation of phagocytosis (GO:0050766)3.04949527
87angiotensin maturation (GO:0002003)3.03809735
88G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.03526021
89cellular response to thyroid hormone stimulus (GO:0097067)3.02708986
90regulation of mast cell activation involved in immune response (GO:0033006)3.00509168
91complement activation, alternative pathway (GO:0006957)2.99663639
92regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.98793144
93negative regulation of interleukin-17 production (GO:0032700)2.97174534
94eosinophil chemotaxis (GO:0048245)2.97050353
95glycosphingolipid catabolic process (GO:0046479)2.96404033
96positive regulation of lymphocyte migration (GO:2000403)2.94603803
97antigen processing and presentation of endogenous antigen (GO:0019883)2.91670233
98positive regulation of leukocyte degranulation (GO:0043302)2.91245582
99barbed-end actin filament capping (GO:0051016)2.91187428
100germinal center formation (GO:0002467)2.89847354
101ceramide catabolic process (GO:0046514)2.89368912
102cellular response to interferon-gamma (GO:0071346)2.88457835
103T-helper 1 type immune response (GO:0042088)2.88240438
104regulation of mast cell activation (GO:0033003)2.88040484
105peptide catabolic process (GO:0043171)2.87523546
106mast cell activation (GO:0045576)2.87132710
107interferon-gamma-mediated signaling pathway (GO:0060333)2.85202977
108myeloid dendritic cell differentiation (GO:0043011)2.84780482
109neutrophil chemotaxis (GO:0030593)2.83539326
110adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.82433435
111detection of biotic stimulus (GO:0009595)2.81711672
112keratan sulfate catabolic process (GO:0042340)2.81555581
113positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.81514196
114positive regulation of smooth muscle cell migration (GO:0014911)2.80548399
115regulation of interleukin-12 biosynthetic process (GO:0045075)2.80520828
116antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.80405142
117regulation of cholesterol storage (GO:0010885)2.79374765
118regulation of inflammatory response to antigenic stimulus (GO:0002861)2.78508919
119positive regulation of gamma-delta T cell activation (GO:0046645)2.78092314
120positive regulation of T cell migration (GO:2000406)2.77500696
121purinergic receptor signaling pathway (GO:0035587)2.77266743
122neutrophil migration (GO:1990266)2.75400733
123response to interferon-gamma (GO:0034341)2.75066538
124negative regulation of interleukin-12 production (GO:0032695)2.74971271
125positive regulation of type 2 immune response (GO:0002830)2.74458217
126cellular response to ethanol (GO:0071361)2.74418393
127antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.74024956
128negative regulation of mast cell activation (GO:0033004)2.73984999
129negative regulation of cell killing (GO:0031342)2.73219811
130negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.73219811
131regulation of leukocyte degranulation (GO:0043300)2.71726569
132myeloid dendritic cell activation (GO:0001773)2.71368756
133regulation of complement activation (GO:0030449)2.70922501
134oligosaccharide catabolic process (GO:0009313)2.70734481
135positive regulation of cholesterol efflux (GO:0010875)2.70678129
136fat-soluble vitamin biosynthetic process (GO:0042362)2.70632758
137surfactant homeostasis (GO:0043129)2.69742883
138positive regulation of chemokine production (GO:0032722)2.69496060
139low-density lipoprotein particle remodeling (GO:0034374)2.67415569
140membrane invagination (GO:0010324)2.66999958
141regulation of chemokine secretion (GO:0090196)2.66031362
142phospholipid efflux (GO:0033700)2.65568380
143response to thyroid hormone (GO:0097066)2.63619434
144N-acetylneuraminate metabolic process (GO:0006054)2.62206605
145cellular response to type I interferon (GO:0071357)2.61511245
146type I interferon signaling pathway (GO:0060337)2.61511245
147regulation of cholesterol esterification (GO:0010872)2.60478456
148response to type I interferon (GO:0034340)2.59296439
149regulation of protein activation cascade (GO:2000257)2.55501613
150hydrogen peroxide biosynthetic process (GO:0050665)2.52034544
151regulation of phagocytosis (GO:0050764)2.50103043
152* humoral immune response (GO:0006959)2.45988360
153positive regulation of acute inflammatory response (GO:0002675)2.43439829
154monocyte chemotaxis (GO:0002548)2.43133359

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.17646286
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.94254236
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.45894073
4* IRF8_27001747_Chip-Seq_BMDM_Mouse5.19120400
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.66561280
6NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.80744299
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.54018356
8* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.09025247
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.04078185
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.02863881
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.85279784
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.41078555
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.38812459
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.37474744
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.36809091
16* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.30873568
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.19552960
18BRD4_27068464_Chip-Seq_AML-cells_Mouse2.16142516
19SPI1_23127762_ChIP-Seq_K562_Human2.14708820
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.13242026
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.12937563
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.12534004
23PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.10849660
24SCL_19346495_ChIP-Seq_HPC-7_Human2.06675373
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.03798255
26* SPI1_23547873_ChIP-Seq_NB4_Human2.01094885
27VDR_24787735_ChIP-Seq_THP-1_Human1.94264195
28RUNX_20019798_ChIP-Seq_JUKART_Human1.84880627
29PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.84482864
30VDR_24763502_ChIP-Seq_THP-1_Human1.76110964
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.75656968
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.74181106
33PU_27001747_Chip-Seq_BMDM_Mouse1.73431712
34CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.71814489
35STAT4_19710469_ChIP-ChIP_TH1__Mouse1.70990339
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.64569183
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60780732
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.59782932
39CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45078250
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40115095
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.39364482
42CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38955472
43CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38111256
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.38093521
45BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.35221456
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34525448
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32630252
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.32628896
49VDR_21846776_ChIP-Seq_THP-1_Human1.32287747
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31578673
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31037796
52CLOCK_20551151_ChIP-Seq_293T_Human1.29192927
53NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.28646185
54FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.28019338
55MAF_26560356_Chip-Seq_TH1_Human1.27667704
56MYB_26560356_Chip-Seq_TH2_Human1.26176663
57SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24846768
58PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24739386
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24517262
60GATA1_22025678_ChIP-Seq_K562_Human1.23156152
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21888241
62TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21243678
63LXR_22158963_ChIP-Seq_LIVER_Mouse1.17656522
64TRIM28_21343339_ChIP-Seq_HEK293_Human1.13681374
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11756264
66RXR_22158963_ChIP-Seq_LIVER_Mouse1.10267305
67ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.08794612
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07797345
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06952256
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06347963
71PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06104878
72CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05388201
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04451995
74SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04410828
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.04308142
76GATA1_19941826_ChIP-Seq_K562_Human1.04104106
77SPI1_20517297_ChIP-Seq_HL60_Human1.03062837
78ESR1_21235772_ChIP-Seq_MCF-7_Human1.01832889
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01435077
80SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00870031
81TCF7_22412390_ChIP-Seq_EML_Mouse0.99766475
82KDM2B_26808549_Chip-Seq_K562_Human0.99272743
83ELK3_25401928_ChIP-Seq_HUVEC_Human0.98897516
84* DROSHA_22980978_ChIP-Seq_HELA_Human0.98324215
85STAT1_20625510_ChIP-Seq_HELA_Human0.98232226
86SMAD_19615063_ChIP-ChIP_OVARY_Human0.96805821
87NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96480622
88GATA2_19941826_ChIP-Seq_K562_Human0.96273883
89* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95760133
90SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95563475
91GATA3_26560356_Chip-Seq_TH2_Human0.95051715
92DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93794122
93MYB_26560356_Chip-Seq_TH1_Human0.93743306
94RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93019358
95RACK7_27058665_Chip-Seq_MCF-7_Human0.92517765
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92368028
97LXR_22292898_ChIP-Seq_THP-1_Human0.92130883
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90555974
99BCL6_27268052_Chip-Seq_Bcells_Human0.90398383
100TBX20_22328084_ChIP-Seq_HEART_Mouse0.89734429
101TBX20_22080862_ChIP-Seq_HEART_Mouse0.89734429
102SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88517241
103NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.87365035
104GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86251407
105GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84834915
106FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.83498984
107* EGR1_19032775_ChIP-ChIP_M12_Human0.82766873
108GATA3_27048872_Chip-Seq_THYMUS_Human0.82533128
109TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81906781
110FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80349853
111UTX_26944678_Chip-Seq_JUKART_Human0.78896477
112SOX2_20726797_ChIP-Seq_SW620_Human0.76381725
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76114271
114CJUN_26792858_Chip-Seq_BT549_Human0.73954441
115KDM2B_26808549_Chip-Seq_DND41_Human0.73812417
116GATA1_22383799_ChIP-Seq_G1ME_Mouse0.73751774
117P63_26484246_Chip-Seq_KERATINOCYTES_Human0.71564193
118ESR2_21235772_ChIP-Seq_MCF-7_Human0.71428108
119SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70550660
120CDX2_19796622_ChIP-Seq_MESCs_Mouse0.69828533
121EGR1_23403033_ChIP-Seq_LIVER_Mouse0.68619010
122CDX2_20551321_ChIP-Seq_CACO-2_Human0.67385630
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.67317474
124NRF2_20460467_ChIP-Seq_MEFs_Mouse0.67317474

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology5.11772091
2MP0001835_abnormal_antigen_presentation4.48277381
3MP0006082_CNS_inflammation3.71853214
4MP0003436_decreased_susceptibility_to3.68187080
5MP0009840_abnormal_foam_cell3.48972717
6MP0002148_abnormal_hypersensitivity_rea3.44272513
7MP0003191_abnormal_cellular_cholesterol3.38114577
8MP0002419_abnormal_innate_immunity3.22430561
9MP0003172_abnormal_lysosome_physiology2.95188316
10MP0005000_abnormal_immune_tolerance2.85423436
11MP0003303_peritoneal_inflammation2.82418051
12MP0002139_abnormal_hepatobiliary_system2.73914815
13MP0005025_abnormal_response_to2.55898752
14MP0003690_abnormal_glial_cell2.55667975
15MP0009785_altered_susceptibility_to2.50001611
16MP0005387_immune_system_phenotype2.48158240
17MP0001790_abnormal_immune_system2.48158240
18MP0003724_increased_susceptibility_to2.44324708
19MP0005464_abnormal_platelet_physiology2.40932596
20MP0005671_abnormal_response_to2.40632745
21MP0002452_abnormal_antigen_presenting2.39125208
22MP0003075_altered_response_to2.35269853
23MP0001533_abnormal_skeleton_physiology2.31745956
24MP0001800_abnormal_humoral_immune2.25712571
25MP0005360_urolithiasis2.14078230
26MP0002723_abnormal_immune_serum2.13862978
27MP0000685_abnormal_immune_system2.13210898
28MP0004510_myositis2.06094419
29MP0000343_altered_response_to2.05384878
30MP0001819_abnormal_immune_cell1.90522175
31MP0002420_abnormal_adaptive_immunity1.88754369
32MP0003329_amyloid_beta_deposits1.85805121
33MP0000604_amyloidosis1.84038881
34MP0002405_respiratory_system_inflammati1.78962310
35MP0001845_abnormal_inflammatory_respons1.69433471
36MP0008469_abnormal_protein_level1.68169418
37MP0005310_abnormal_salivary_gland1.64849009
38MP0008438_abnormal_cutaneous_collagen1.63579306
39MP0005365_abnormal_bile_salt1.61215604
40MP0005166_decreased_susceptibility_to1.59675175
41MP0001853_heart_inflammation1.58165638
42MP0003300_gastrointestinal_ulcer1.52401991
43MP0002998_abnormal_bone_remodeling1.47476380
44MP0004947_skin_inflammation1.43394857
45MP0009764_decreased_sensitivity_to1.42662657
46MP0009333_abnormal_splenocyte_physiolog1.38512872
47MP0003448_altered_tumor_morphology1.34751166
48MP0000465_gastrointestinal_hemorrhage1.30084499
49MP0000716_abnormal_immune_system1.29052613
50MP0005167_abnormal_blood-brain_barrier1.27581135
51MP0010155_abnormal_intestine_physiology1.25267270
52MP0004883_abnormal_blood_vessel1.23351306
53MP0000689_abnormal_spleen_morphology1.22790772
54MP0003828_pulmonary_edema1.21551679
55MP0002277_abnormal_respiratory_mucosa1.16818625
56MP0004019_abnormal_vitamin_homeostasis1.15475311
57MP0009278_abnormal_bone_marrow1.13044235
58MP0003183_abnormal_peptide_metabolism1.11519717
59MP0005451_abnormal_body_composition1.10429422
60MP0002398_abnormal_bone_marrow1.08923177
61MP0005390_skeleton_phenotype1.07572463
62MP0001851_eye_inflammation1.06185353
63MP0003195_calcinosis1.04449012
64MP0005164_abnormal_response_to1.03693793
65MP0000249_abnormal_blood_vessel1.03631837
66MP0001958_emphysema1.03601462
67MP0003453_abnormal_keratinocyte_physiol1.02965379
68MP0002429_abnormal_blood_cell1.02499637
69MP0009763_increased_sensitivity_to1.00754910
70MP0003279_aneurysm0.98668911
71MP0004782_abnormal_surfactant_physiolog0.98230007
72MP0002166_altered_tumor_susceptibility0.97300993
73MP0003879_abnormal_hair_cell0.97066601
74MP0003091_abnormal_cell_migration0.96649111
75MP0003806_abnormal_nucleotide_metabolis0.96522346
76MP0000858_altered_metastatic_potential0.95687567
77MP0002722_abnormal_immune_system0.95005366
78MP0002090_abnormal_vision0.93882962
79MP0010307_abnormal_tumor_latency0.93844059
80MP0003566_abnormal_cell_adhesion0.92554519
81MP0002933_joint_inflammation0.92114236
82MP0005595_abnormal_vascular_smooth0.92000457
83MP0003045_fibrosis0.89947192
84MP0000920_abnormal_myelination0.89716527
85MP0001663_abnormal_digestive_system0.86882036
86MP0005670_abnormal_white_adipose0.86520719
87MP0003705_abnormal_hypodermis_morpholog0.86132040
88MP0003866_abnormal_defecation0.84079391
89MP0005165_increased_susceptibility_to0.83287115
90MP0002971_abnormal_brown_adipose0.83164754
91MP0000767_abnormal_smooth_muscle0.83084841
92MP0002254_reproductive_system_inflammat0.83061927
93MP0005085_abnormal_gallbladder_physiolo0.82981787
94MP0008004_abnormal_stomach_pH0.81161750
95MP0000609_abnormal_liver_physiology0.80810884
96MP0001666_abnormal_nutrient_absorption0.78601115
97MP0002006_tumorigenesis0.77600968
98MP0009643_abnormal_urine_homeostasis0.76163229
99MP0008260_abnormal_autophagy0.75095563
100MP0005397_hematopoietic_system_phenotyp0.74678675
101MP0001545_abnormal_hematopoietic_system0.74678675
102MP0001915_intracranial_hemorrhage0.74255887
103MP0003795_abnormal_bone_structure0.72397787
104MP0004858_abnormal_nervous_system0.71863141
105MP0002136_abnormal_kidney_physiology0.71042244
106MP0005257_abnormal_intraocular_pressure0.69715064
107MP0002138_abnormal_hepatobiliary_system0.69383040
108MP0002118_abnormal_lipid_homeostasis0.69025499
109MP0003011_delayed_dark_adaptation0.68038096
110MP0008873_increased_physiological_sensi0.67966260
111MP0004130_abnormal_muscle_cell0.67353806
112MP0000569_abnormal_digit_pigmentation0.66734854
113MP0009115_abnormal_fat_cell0.66324603
114MP0002896_abnormal_bone_mineralization0.64686362
115MP0003656_abnormal_erythrocyte_physiolo0.61843394
116MP0005584_abnormal_enzyme/coenzyme_acti0.59868926
117MP0010329_abnormal_lipoprotein_level0.58565502
118MP0000371_diluted_coat_color0.58200750
119MP0003633_abnormal_nervous_system0.57396280
120MP0005076_abnormal_cell_differentiation0.56867314
121MP0005023_abnormal_wound_healing0.55906581
122MP0003252_abnormal_bile_duct0.54790196
123MP0003634_abnormal_glial_cell0.54630230
124MP0001542_abnormal_bone_strength0.51752650
125MP0000015_abnormal_ear_pigmentation0.51650523

Predicted human phenotypes

RankGene SetZ-score
1* Systemic lupus erythematosus (HP:0002725)9.26294555
2* Glomerulonephritis (HP:0000099)6.87268307
3Recurrent abscess formation (HP:0002722)6.36221596
4Increased cerebral lipofuscin (HP:0011813)5.98437453
5Recurrent bacterial skin infections (HP:0005406)5.82830067
6Increased neuronal autofluorescent lipopigment (HP:0002074)5.63402025
7Vacuolated lymphocytes (HP:0001922)5.56805076
8* Complement deficiency (HP:0004431)5.45519397
9Eczematoid dermatitis (HP:0000976)5.25768580
10Abnormality of liposaccharide metabolism (HP:0010968)5.21265724
11Abnormality of glycosphingolipid metabolism (HP:0004343)5.21265724
12Abnormality of glycolipid metabolism (HP:0010969)5.21265724
13Dysostosis multiplex (HP:0000943)5.19735542
14* Abnormality of complement system (HP:0005339)5.16661513
15Recurrent gram-negative bacterial infections (HP:0005420)4.64055492
16Axonal loss (HP:0003447)4.27524647
17Disinhibition (HP:0000734)4.21959759
18Mucopolysacchariduria (HP:0008155)3.88384020
19Urinary glycosaminoglycan excretion (HP:0003541)3.88384020
20* Nephritis (HP:0000123)3.77300725
21Abnormality of macrophages (HP:0004311)3.73704817
22Abnormality of mucopolysaccharide metabolism (HP:0011020)3.66982672
23Abnormality of polysaccharide metabolism (HP:0011012)3.66982672
24Abnormality of glycosaminoglycan metabolism (HP:0004371)3.66982672
25Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.64618611
26Agnosia (HP:0010524)3.43263309
27Recurrent skin infections (HP:0001581)3.27968448
28Malnutrition (HP:0004395)3.16025578
29Thick nail (HP:0001805)3.16005914
30Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.14829239
31Upper motor neuron abnormality (HP:0002127)3.12916037
32Mediastinal lymphadenopathy (HP:0100721)3.08672882
33Gingivitis (HP:0000230)2.99456576
34Myositis (HP:0100614)2.90282320
35Spontaneous hematomas (HP:0007420)2.86198743
36Pustule (HP:0200039)2.83818638
37Arterial tortuosity (HP:0005116)2.83589200
38Mutism (HP:0002300)2.82356521
39Retinal atrophy (HP:0001105)2.80332561
40Chronic obstructive pulmonary disease (HP:0006510)2.76841364
41Obstructive lung disease (HP:0006536)2.76841364
42Orchitis (HP:0100796)2.71978647
43Hematochezia (HP:0002573)2.70485941
44Loss of speech (HP:0002371)2.69188749
45Hepatosplenomegaly (HP:0001433)2.67191318
46Elevated erythrocyte sedimentation rate (HP:0003565)2.63334659
47Pathologic fracture (HP:0002756)2.61891845
48Myocardial infarction (HP:0001658)2.59240250
49Basal ganglia calcification (HP:0002135)2.56879547
50Asymmetric septal hypertrophy (HP:0001670)2.52873617
51Vascular tortuosity (HP:0004948)2.45503053
52Progressive visual loss (HP:0000529)2.44874745
53Periodontitis (HP:0000704)2.42415164
54Prostate neoplasm (HP:0100787)2.41550087
55Recurrent fungal infections (HP:0002841)2.41478361
56J-shaped sella turcica (HP:0002680)2.41190581
57Hemoptysis (HP:0002105)2.40596733
58Cerebral aneurysm (HP:0004944)2.40492952
59Cellulitis (HP:0100658)2.39262954
60Autoimmune thrombocytopenia (HP:0001973)2.38327568
61Osteolytic defects of the hand bones (HP:0009699)2.37095652
62Osteolytic defects of the phalanges of the hand (HP:0009771)2.37095652
63Recurrent viral infections (HP:0004429)2.36338302
64Cerebral inclusion bodies (HP:0100314)2.35447705
65Colitis (HP:0002583)2.32209196
66Abnormality of monocarboxylic acid metabolism (HP:0010996)2.31470760
67Progressive neurologic deterioration (HP:0002344)2.30794436
68Petechiae (HP:0000967)2.30215024
69Nuclear cataract (HP:0100018)2.28773619
70Joint hemorrhage (HP:0005261)2.25863136
71Retrobulbar optic neuritis (HP:0100654)2.22966672
72Optic neuritis (HP:0100653)2.22966672
73Xanthomatosis (HP:0000991)2.22514252
74Inappropriate behavior (HP:0000719)2.21902192
75Amyloidosis (HP:0011034)2.19837729
76Thoracic kyphosis (HP:0002942)2.18087024
77Esophageal neoplasm (HP:0100751)2.17764206
78Neoplasm of head and neck (HP:0012288)2.17764206
79Stomatitis (HP:0010280)2.16492836
80Neurofibrillary tangles (HP:0002185)2.16110962
81Peripheral demyelination (HP:0011096)2.14701452
82Abnormality of the nasal mucosa (HP:0000433)2.13365543
83Recurrent cutaneous fungal infections (HP:0011370)2.12163869
84Chronic mucocutaneous candidiasis (HP:0002728)2.12163869
85Premature loss of primary teeth (HP:0006323)2.11980208
86Abnormality of the lumbar spine (HP:0100712)2.11948266
87Osteomyelitis (HP:0002754)2.08709325
88Abnormality of the vasculature of the conjunctiva (HP:0008054)2.08552484
89Apathy (HP:0000741)2.05145583
90Urticaria (HP:0001025)2.04625614
91Neuronal loss in central nervous system (HP:0002529)2.02450401
92Spondylolisthesis (HP:0003302)2.01659919
93Hemorrhage of the eye (HP:0011885)2.00990663
94Abnormality of iron homeostasis (HP:0011031)2.00626445
95Bone pain (HP:0002653)1.99846812
96Diminished motivation (HP:0000745)1.98586113
97Segmental peripheral demyelination/remyelination (HP:0003481)1.98582452
98Interstitial pulmonary disease (HP:0006530)1.96530927
99Personality changes (HP:0000751)1.96342628
100Pulmonary infiltrates (HP:0002113)1.95484893
101Increased CSF protein (HP:0002922)1.95025017
102Inflammation of the large intestine (HP:0002037)1.92408050
103Vasculitis (HP:0002633)1.89419152
104Increased serum ferritin (HP:0003281)1.88621867
105Abnormality of glutamine family amino acid metabolism (HP:0010902)1.87895001
106Abnormality of the periventricular white matter (HP:0002518)1.87015215
107Arterial thrombosis (HP:0004420)1.86341993
108Leukocytosis (HP:0001974)1.84339420
109Recurrent pneumonia (HP:0006532)1.84231807
110Conjunctival telangiectasia (HP:0000524)1.83729324
111Restrictive lung disease (HP:0002091)1.81010805
112Disproportionate tall stature (HP:0001519)1.80726583
113Meningitis (HP:0001287)1.80571506
114Decreased circulating renin level (HP:0003351)1.78964633
115Gastrointestinal stroma tumor (HP:0100723)1.78539618
116Dementia (HP:0000726)1.78322143
117Gastrointestinal inflammation (HP:0004386)1.74319343
118Pulmonary embolism (HP:0002204)1.73800078
119Chronic otitis media (HP:0000389)1.73722301
120Emphysema (HP:0002097)1.73492163
121Purpura (HP:0000979)1.73382975
122Joint stiffness (HP:0001387)1.72695558
123Vertebral compression fractures (HP:0002953)1.72553533
124Spinal muscular atrophy (HP:0007269)1.71817281
125Memory impairment (HP:0002354)1.71264177
126Bone cyst (HP:0012062)1.70620792
127Thin bony cortex (HP:0002753)1.67290758
128Polycythemia (HP:0001901)1.66722416
129Pulmonary hypertension (HP:0002092)1.64382953

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR25.32199844
2BLK5.04107301
3TYK23.54909069
4GRK73.33133437
5IRAK43.28119071
6RIPK43.21807279
7MAP3K142.98869342
8TBK12.88852133
9ERN12.57629568
10CSF1R2.37595030
11KIT2.26337794
12MAP4K12.19196282
13IRAK32.14880465
14DDR22.00846485
15CAMK1D1.93839984
16CDC42BPA1.88109310
17IKBKB1.87926073
18JAK11.87134315
19ZAP701.82226262
20NEK91.70514873
21EPHA31.69321502
22IKBKE1.67080987
23TXK1.66569843
24HCK1.61673964
25PRPF4B1.56716026
26CSK1.44410917
27EPHB11.41645905
28BTK1.37361648
29LYN1.37050568
30ACVR1B1.36772534
31STK101.34308345
32MAPK151.33596205
33SYK1.28397733
34CAMK1G1.26509206
35JAK21.23416285
36FES1.19366190
37CAMKK21.18966455
38MAP3K11.13597489
39LCK1.12385877
40CLK11.10269811
41ADRBK21.09363333
42PKN21.08390816
43BMPR21.05609635
44MOS1.05275628
45PAK41.03928316
46TAOK11.00215502
47TAOK20.99517187
48EPHB20.99050337
49NME20.98446587
50MAP2K30.98111102
51MATK0.96808874
52TEC0.95862419
53CAMKK10.93952353
54JAK30.92151883
55PDK20.91688585
56MST1R0.90566024
57ITK0.89747297
58PDGFRA0.89297258
59SCYL20.88813557
60CHUK0.88285314
61FGR0.87887331
62PRKG20.85675337
63TRIB30.84768209
64TAOK30.83176240
65EGFR0.76599139
66BMX0.73646266
67YES10.73008895
68MAPK120.72078669
69CDK60.69496472
70IGF1R0.66490930
71TESK10.66336432
72PIM20.66233393
73EIF2AK20.65724385
74DMPK0.65629479
75PRKCD0.63772064
76TNK20.61688744
77PTK60.61453403
78PIK3CG0.60863681
79MAPK70.59950392
80MAP3K130.59640345
81MARK20.57726058
82SIK20.57677267
83PRKAA20.57136234
84MAP3K30.57038142
85HIPK20.56002223
86MAPKAPK20.55520799
87ABL10.49584970
88SIK10.48725980
89GRK50.47982480
90PDK10.47438384
91TTN0.46932537
92IRAK20.46380250
93MAP3K60.46278849
94FYN0.44672103
95RIPK10.44655531
96MAP3K50.44291283
97TESK20.42866374
98RET0.42433526
99PRKD10.41789517
100FGFR40.41176585
101FGFR30.41146807
102FER0.40914316
103MYLK0.40227940
104MAP3K110.40093299
105ABL20.38958774
106PRKACG0.38460107
107PBK0.37388709
108PDPK10.37277939
109IRAK10.36319270
110PIM10.36114893
111MARK30.33641537
112ICK0.32466753
113CAMK2G0.32200677
114GSK3A0.31052991
115RPS6KA20.30870632
116INSR0.30412744
117MAPK40.29559199
118TRPM70.28126162
119PDGFRB0.26703562
120RPS6KA60.25375885
121CAMK40.24559754
122RPS6KA40.23840218
123SGK30.23642384
124PKN10.23625893
125SRC0.22098276
126RPS6KC10.18899629
127RPS6KL10.18899629
128MAPKAPK50.18278039
129PAK20.18223901

Predicted pathways (KEGG)

RankGene SetZ-score
1* Staphylococcus aureus infection_Homo sapiens_hsa051505.87172896
2Glycosaminoglycan degradation_Homo sapiens_hsa005314.11368426
3Other glycan degradation_Homo sapiens_hsa005113.83690267
4Lysosome_Homo sapiens_hsa041423.53910079
5Leishmaniasis_Homo sapiens_hsa051402.96222963
6Osteoclast differentiation_Homo sapiens_hsa043802.67214875
7* Pertussis_Homo sapiens_hsa051332.59066965
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.44582511
9* Complement and coagulation cascades_Homo sapiens_hsa046102.27493385
10Tuberculosis_Homo sapiens_hsa051522.10993765
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.06683187
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.98769123
13Legionellosis_Homo sapiens_hsa051341.95784446
14Malaria_Homo sapiens_hsa051441.87301815
15* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.80093599
16Phagosome_Homo sapiens_hsa041451.79592858
17B cell receptor signaling pathway_Homo sapiens_hsa046621.77297291
18Antigen processing and presentation_Homo sapiens_hsa046121.69156974
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.63050089
20Rheumatoid arthritis_Homo sapiens_hsa053231.55811569
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.55025301
22Measles_Homo sapiens_hsa051621.47347285
23Toxoplasmosis_Homo sapiens_hsa051451.47012472
24Salmonella infection_Homo sapiens_hsa051321.46124463
25* Prion diseases_Homo sapiens_hsa050201.39776521
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.35301478
27Chemokine signaling pathway_Homo sapiens_hsa040621.26190961
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22725606
29Influenza A_Homo sapiens_hsa051641.22362153
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.17903457
31Graft-versus-host disease_Homo sapiens_hsa053321.16655514
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.14216056
33Histidine metabolism_Homo sapiens_hsa003401.12266650
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10778611
35Hematopoietic cell lineage_Homo sapiens_hsa046401.09839196
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.05796333
37Asthma_Homo sapiens_hsa053101.02336308
38Apoptosis_Homo sapiens_hsa042101.01513653
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01066267
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00879555
41Allograft rejection_Homo sapiens_hsa053300.99674031
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94987151
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94213033
44African trypanosomiasis_Homo sapiens_hsa051430.87090904
45Shigellosis_Homo sapiens_hsa051310.86629514
46TNF signaling pathway_Homo sapiens_hsa046680.85829418
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85393149
48Caffeine metabolism_Homo sapiens_hsa002320.83986009
49Amoebiasis_Homo sapiens_hsa051460.83959110
50* Systemic lupus erythematosus_Homo sapiens_hsa053220.80307379
51Jak-STAT signaling pathway_Homo sapiens_hsa046300.79605973
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.78820559
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78321024
54Herpes simplex infection_Homo sapiens_hsa051680.75511553
55Endocytosis_Homo sapiens_hsa041440.75334209
56Platelet activation_Homo sapiens_hsa046110.75083017
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73393651
58Fructose and mannose metabolism_Homo sapiens_hsa000510.71285999
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69703500
60Hepatitis B_Homo sapiens_hsa051610.69328505
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69237151
62Galactose metabolism_Homo sapiens_hsa000520.68652777
63Fat digestion and absorption_Homo sapiens_hsa049750.68525962
64Arachidonic acid metabolism_Homo sapiens_hsa005900.68518690
65Pancreatic cancer_Homo sapiens_hsa052120.64338817
66Chronic myeloid leukemia_Homo sapiens_hsa052200.63603266
67ABC transporters_Homo sapiens_hsa020100.63509314
68Hepatitis C_Homo sapiens_hsa051600.62425477
69Arginine biosynthesis_Homo sapiens_hsa002200.62308572
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59960839
71Tryptophan metabolism_Homo sapiens_hsa003800.59811969
72Mineral absorption_Homo sapiens_hsa049780.58391458
73Viral myocarditis_Homo sapiens_hsa054160.56689609
74Sulfur metabolism_Homo sapiens_hsa009200.56602147
75Sphingolipid metabolism_Homo sapiens_hsa006000.53719945
76Bile secretion_Homo sapiens_hsa049760.49827050
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.47453372
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46935869
79Fatty acid degradation_Homo sapiens_hsa000710.45693851
80Nitrogen metabolism_Homo sapiens_hsa009100.45116896
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45079187
82Primary immunodeficiency_Homo sapiens_hsa053400.44953213
83T cell receptor signaling pathway_Homo sapiens_hsa046600.43961695
84Renin secretion_Homo sapiens_hsa049240.43789858
85Ether lipid metabolism_Homo sapiens_hsa005650.43713632
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.43341928
87Renin-angiotensin system_Homo sapiens_hsa046140.42705523
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40687162
89Retinol metabolism_Homo sapiens_hsa008300.39660446
90Chemical carcinogenesis_Homo sapiens_hsa052040.39131980
91Linoleic acid metabolism_Homo sapiens_hsa005910.37662488
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37392208
93Type I diabetes mellitus_Homo sapiens_hsa049400.36843944
94Acute myeloid leukemia_Homo sapiens_hsa052210.36576238
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36086877
96Vibrio cholerae infection_Homo sapiens_hsa051100.36076104
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33090759
98Notch signaling pathway_Homo sapiens_hsa043300.32002550
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31239789
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31199457
101Autoimmune thyroid disease_Homo sapiens_hsa053200.31013534
102Phenylalanine metabolism_Homo sapiens_hsa003600.30929955
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30625852
104PPAR signaling pathway_Homo sapiens_hsa033200.30243625
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.29939610
106Starch and sucrose metabolism_Homo sapiens_hsa005000.29764186
107Prolactin signaling pathway_Homo sapiens_hsa049170.28931982
108Protein digestion and absorption_Homo sapiens_hsa049740.28615452
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.27192384
110GnRH signaling pathway_Homo sapiens_hsa049120.27186914
111Collecting duct acid secretion_Homo sapiens_hsa049660.26332036
112HIF-1 signaling pathway_Homo sapiens_hsa040660.26278046
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.24759889
114Primary bile acid biosynthesis_Homo sapiens_hsa001200.22325716
115Type II diabetes mellitus_Homo sapiens_hsa049300.22136664
116Adherens junction_Homo sapiens_hsa045200.18552942
117Proteoglycans in cancer_Homo sapiens_hsa052050.17774726
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17149829
119Renal cell carcinoma_Homo sapiens_hsa052110.17033601
120VEGF signaling pathway_Homo sapiens_hsa043700.16905364
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16648698
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.16502643
123Insulin resistance_Homo sapiens_hsa049310.15255098
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.14069553
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.09841366
126Vitamin digestion and absorption_Homo sapiens_hsa049770.09713021

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