C1ORF94

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)6.18999513
2rRNA methylation (GO:0031167)5.93463971
3rRNA modification (GO:0000154)5.64941227
4single strand break repair (GO:0000012)5.48385835
5acrosome reaction (GO:0007340)5.45509948
6chromosome condensation (GO:0030261)5.45338651
7regulation of centriole replication (GO:0046599)5.38272337
8microtubule depolymerization (GO:0007019)5.21488834
9fusion of sperm to egg plasma membrane (GO:0007342)5.19457628
10DNA packaging (GO:0006323)5.17666513
11histone exchange (GO:0043486)5.04935235
12microtubule polymerization or depolymerization (GO:0031109)4.87626979
13response to pheromone (GO:0019236)4.70845947
14centriole replication (GO:0007099)4.65082195
15spermatid development (GO:0007286)4.58255246
16nuclear pore complex assembly (GO:0051292)4.38215775
17sperm-egg recognition (GO:0035036)4.36347199
18chromatin remodeling at centromere (GO:0031055)4.24301138
19CENP-A containing nucleosome assembly (GO:0034080)4.12658927
20binding of sperm to zona pellucida (GO:0007339)4.11598875
21IMP biosynthetic process (GO:0006188)4.11579934
22purine nucleobase biosynthetic process (GO:0009113)4.04217885
23establishment of integrated proviral latency (GO:0075713)4.00070006
24protein polyglutamylation (GO:0018095)3.98249489
25sperm capacitation (GO:0048240)3.97766016
26DNA replication checkpoint (GO:0000076)3.89021328
27plasma membrane fusion (GO:0045026)3.81967180
28regulation of gene silencing by RNA (GO:0060966)3.79055631
29regulation of posttranscriptional gene silencing (GO:0060147)3.79055631
30regulation of gene silencing by miRNA (GO:0060964)3.79055631
31ribosome assembly (GO:0042255)3.71923563
32L-serine metabolic process (GO:0006563)3.70744555
33IMP metabolic process (GO:0046040)3.68653463
34centriole assembly (GO:0098534)3.66387201
35nucleobase biosynthetic process (GO:0046112)3.62931821
36DNA double-strand break processing (GO:0000729)3.60758607
37protein targeting to Golgi (GO:0000042)3.59911835
38nuclear pore organization (GO:0006999)3.59372510
39spermatogenesis (GO:0007283)3.54601966
40male gamete generation (GO:0048232)3.53846713
41spermatid nucleus differentiation (GO:0007289)3.50145499
42DNA replication-independent nucleosome organization (GO:0034724)3.47847409
43DNA replication-independent nucleosome assembly (GO:0006336)3.47847409
44establishment of protein localization to Golgi (GO:0072600)3.43250499
45chromatin silencing (GO:0006342)3.36962669
46gamete generation (GO:0007276)3.33752818
47cell-cell recognition (GO:0009988)3.33317235
48protein complex localization (GO:0031503)3.33250499
49regulation of mitotic spindle checkpoint (GO:1903504)3.32283666
50regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.32283666
51anterior/posterior axis specification, embryo (GO:0008595)3.31975423
52pore complex assembly (GO:0046931)3.31060691
53multicellular organism reproduction (GO:0032504)3.29594543
54L-alpha-amino acid transmembrane transport (GO:1902475)3.28666472
55DNA replication-dependent nucleosome assembly (GO:0006335)3.25679889
56DNA replication-dependent nucleosome organization (GO:0034723)3.25679889
57histone mRNA metabolic process (GO:0008334)3.24464891
58ATP-dependent chromatin remodeling (GO:0043044)3.23054585
59negative regulation of inclusion body assembly (GO:0090084)3.17097666
60mitotic metaphase plate congression (GO:0007080)3.13475092
61retrograde transport, vesicle recycling within Golgi (GO:0000301)3.12681530
62axonemal dynein complex assembly (GO:0070286)3.10544442
63pre-miRNA processing (GO:0031054)3.08713085
64establishment of viral latency (GO:0019043)3.07897065
65proteasome assembly (GO:0043248)3.04206000
66protein localization to kinetochore (GO:0034501)3.03441874
67seminiferous tubule development (GO:0072520)3.02973439
68negative regulation of DNA-dependent DNA replication (GO:2000104)3.01390284
69glomerular visceral epithelial cell development (GO:0072015)3.01171735
70chaperone-mediated protein transport (GO:0072321)2.91360628
71negative regulation of DNA recombination (GO:0045910)2.91278170
72regulation of chromosome segregation (GO:0051983)2.88648960
73negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.87840251
74negative regulation of translation, ncRNA-mediated (GO:0040033)2.87840251
75regulation of translation, ncRNA-mediated (GO:0045974)2.87840251
76negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.87763202
77negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.87763202
78negative regulation of mitotic sister chromatid segregation (GO:0033048)2.87763202
79negative regulation of mitotic sister chromatid separation (GO:2000816)2.87763202
80negative regulation of sister chromatid segregation (GO:0033046)2.87763202
81regulation of cilium movement (GO:0003352)2.85858038
82mitotic G2/M transition checkpoint (GO:0044818)2.84437289
83histone H2A monoubiquitination (GO:0035518)2.83527599
84single fertilization (GO:0007338)2.81990540
85negative regulation of chromosome segregation (GO:0051985)2.81459618
86regulation of mesoderm development (GO:2000380)2.80779284
87DNA conformation change (GO:0071103)2.80314227
88DNA strand elongation involved in DNA replication (GO:0006271)2.78936685
89tRNA methylation (GO:0030488)2.78474592
90regulation of nuclear cell cycle DNA replication (GO:0033262)2.78372491
91lysine metabolic process (GO:0006553)2.78142929
92lysine catabolic process (GO:0006554)2.78142929
93reproduction (GO:0000003)2.76856893
94multicellular organismal movement (GO:0050879)2.74998303
95musculoskeletal movement (GO:0050881)2.74998303
96calcium ion-dependent exocytosis (GO:0017156)2.73799320
97glomerular epithelial cell development (GO:0072310)2.73314149
98germ cell development (GO:0007281)2.70477159
99cell wall macromolecule catabolic process (GO:0016998)2.68673823
100somatic hypermutation of immunoglobulin genes (GO:0016446)2.68408887

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.13104628
2MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.73871933
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.09607310
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.04097992
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.68589608
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.49685876
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.47043023
8FUS_26573619_Chip-Seq_HEK293_Human2.46975665
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.40080270
10VDR_22108803_ChIP-Seq_LS180_Human2.32265086
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.30589445
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.13356131
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10182285
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05582175
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98292431
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.97033172
17POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.92589606
18TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92589606
19CREB1_15753290_ChIP-ChIP_HEK293T_Human1.91497161
20MYC_19079543_ChIP-ChIP_MESCs_Mouse1.90971001
21P300_19829295_ChIP-Seq_ESCs_Human1.87795222
22KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.84140014
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.84140014
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.84140014
25MYC_19030024_ChIP-ChIP_MESCs_Mouse1.82369085
26ZNF274_21170338_ChIP-Seq_K562_Hela1.81805062
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74711165
28POU5F1_16153702_ChIP-ChIP_HESCs_Human1.74492042
29NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.68728321
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68479536
31SOX2_16153702_ChIP-ChIP_HESCs_Human1.67092321
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.65435951
33* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65130912
34SOX2_18555785_ChIP-Seq_MESCs_Mouse1.63618642
35NANOG_16153702_ChIP-ChIP_HESCs_Human1.63588906
36CBP_20019798_ChIP-Seq_JUKART_Human1.54042329
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54042329
38TAF15_26573619_Chip-Seq_HEK293_Human1.52315018
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52227241
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.50689040
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.49600857
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40998101
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40908879
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37673037
45ELK1_19687146_ChIP-ChIP_HELA_Human1.35880699
46EWS_26573619_Chip-Seq_HEK293_Human1.33827428
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32885709
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32440435
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32410276
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.28915062
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27583844
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27375518
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25673608
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24897074
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.24272572
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.23778292
57* RBPJ_21746931_ChIP-Seq_IB4_Human1.21664932
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.17370270
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17058899
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.16564443
61AR_21909140_ChIP-Seq_LNCAP_Human1.16341423
62DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15790359
63MYC_18940864_ChIP-ChIP_HL60_Human1.15369162
64SMAD3_21741376_ChIP-Seq_ESCs_Human1.14847563
65* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.14828566
66HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.14028322
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13969764
68SMAD4_21741376_ChIP-Seq_EPCs_Human1.13740822
69EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.13504240
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12628349
71CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11819884
72* ETV1_20927104_ChIP-Seq_GIST48_Human1.10335870
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10199472
74* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.09918552
75SOX2_19829295_ChIP-Seq_ESCs_Human1.07945938
76NANOG_19829295_ChIP-Seq_ESCs_Human1.07945938
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07378963
78E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05786576
79GATA1_26923725_Chip-Seq_HPCs_Mouse1.05458166
80MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05113780
81TTF2_22483619_ChIP-Seq_HELA_Human1.05016532
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04548378
83ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04448950
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02260099
85MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02155695
86KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99392248
87TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99378943
88MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97472442
89NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97109186
90* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.96650984
91* PHF8_20622853_ChIP-Seq_HELA_Human0.96008479
92TP63_19390658_ChIP-ChIP_HaCaT_Human0.95839504
93* HNFA_21074721_ChIP-Seq_CACO-2_Human0.95419833
94NELFA_20434984_ChIP-Seq_ESCs_Mouse0.95391782
95FOXP3_21729870_ChIP-Seq_TREG_Human0.91674186
96TBX3_20139965_ChIP-Seq_MESCs_Mouse0.91497296
97TBX3_20139965_ChIP-Seq_ESCs_Mouse0.91322503
98ER_23166858_ChIP-Seq_MCF-7_Human0.90841146
99POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90830886
100* NFYB_21822215_ChIP-Seq_K562_Human0.89996592

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.74853465
2MP0002254_reproductive_system_inflammat3.46310828
3MP0003941_abnormal_skin_development3.41026704
4MP0003890_abnormal_embryonic-extraembry3.12014514
5MP0004957_abnormal_blastocyst_morpholog2.94540712
6MP0003693_abnormal_embryo_hatching2.84439035
7MP0008877_abnormal_DNA_methylation2.82037652
8MP0010094_abnormal_chromosome_stability2.79028963
9MP0003878_abnormal_ear_physiology2.75501464
10MP0005377_hearing/vestibular/ear_phenot2.75501464
11MP0008058_abnormal_DNA_repair2.73832410
12MP0003718_maternal_effect2.61167472
13MP0006292_abnormal_olfactory_placode2.55073271
14MP0003698_abnormal_male_reproductive2.39759471
15MP0001929_abnormal_gametogenesis2.39605930
16MP0003077_abnormal_cell_cycle2.27193261
17MP0008007_abnormal_cellular_replicative2.20786536
18MP0008057_abnormal_DNA_replication2.19997091
19MP0009697_abnormal_copulation2.14778610
20MP0003111_abnormal_nucleus_morphology2.13461035
21MP0008932_abnormal_embryonic_tissue2.11693392
22MP0001293_anophthalmia1.99244118
23MP0003136_yellow_coat_color1.99161731
24MP0001485_abnormal_pinna_reflex1.95535028
25MP0003119_abnormal_digestive_system1.93581559
26MP0001188_hyperpigmentation1.83757187
27MP0001984_abnormal_olfaction1.67243195
28MP0002736_abnormal_nociception_after1.52538032
29MP0005670_abnormal_white_adipose1.49434809
30MP0002161_abnormal_fertility/fecundity1.47688880
31MP0002210_abnormal_sex_determination1.46531635
32MP0000049_abnormal_middle_ear1.45905348
33MP0009379_abnormal_foot_pigmentation1.44675978
34MP0009672_abnormal_birth_weight1.40983139
35MP0002653_abnormal_ependyma_morphology1.38366131
36MP0003937_abnormal_limbs/digits/tail_de1.38079788
37MP0001730_embryonic_growth_arrest1.31379373
38MP0000579_abnormal_nail_morphology1.30553171
39MP0002085_abnormal_embryonic_tissue1.28543021
40MP0001145_abnormal_male_reproductive1.26440386
41MP0004133_heterotaxia1.25878944
42MP0005423_abnormal_somatic_nervous1.23042242
43MP0001529_abnormal_vocalization1.21742791
44MP0003011_delayed_dark_adaptation1.16676667
45MP0001486_abnormal_startle_reflex1.14337521
46MP0002084_abnormal_developmental_patter1.12370281
47MP0000653_abnormal_sex_gland1.12368609
48MP0006072_abnormal_retinal_apoptosis1.09233065
49MP0005499_abnormal_olfactory_system1.08916599
50MP0005394_taste/olfaction_phenotype1.08916599
51MP0002735_abnormal_chemical_nociception1.06814217
52MP0002697_abnormal_eye_size1.06287538
53MP0001286_abnormal_eye_development1.06087084
54MP0001177_atelectasis1.04790779
55MP0001672_abnormal_embryogenesis/_devel1.04475773
56MP0005380_embryogenesis_phenotype1.04475773
57MP0003567_abnormal_fetal_cardiomyocyte1.02586900
58MP0003121_genomic_imprinting1.01849074
59MP0000350_abnormal_cell_proliferation0.98152463
60MP0001968_abnormal_touch/_nociception0.95652023
61MP0004859_abnormal_synaptic_plasticity0.94240442
62MP0004742_abnormal_vestibular_system0.93134639
63MP0002080_prenatal_lethality0.91021764
64MP0002938_white_spotting0.87387865
65MP0001697_abnormal_embryo_size0.87370313
66MP0003861_abnormal_nervous_system0.86060993
67MP0001299_abnormal_eye_distance/0.84331577
68MP0005253_abnormal_eye_physiology0.83137769
69MP0005395_other_phenotype0.79922290
70MP0009053_abnormal_anal_canal0.79738117
71MP0003786_premature_aging0.79310577
72MP0003646_muscle_fatigue0.78502049
73MP0010030_abnormal_orbit_morphology0.77175995
74MP0008789_abnormal_olfactory_epithelium0.76943136
75MP0001963_abnormal_hearing_physiology0.76232395
76MP0005551_abnormal_eye_electrophysiolog0.75266241
77MP0002111_abnormal_tail_morphology0.73559817
78MP0002249_abnormal_larynx_morphology0.73445808
79MP0005391_vision/eye_phenotype0.72217407
80MP0010307_abnormal_tumor_latency0.72188519
81MP0002090_abnormal_vision0.71873634
82MP0002734_abnormal_mechanical_nocicepti0.71298960
83MP0000313_abnormal_cell_death0.68847304
84MP0009703_decreased_birth_body0.68412927
85MP0002233_abnormal_nose_morphology0.68271070
86MP0003787_abnormal_imprinting0.68270616
87MP0006035_abnormal_mitochondrial_morpho0.67032482
88MP0003880_abnormal_central_pattern0.66880380
89MP0003137_abnormal_impulse_conducting0.65671372
90MP0004197_abnormal_fetal_growth/weight/0.65160637
91MP0003984_embryonic_growth_retardation0.64268046
92MP0004215_abnormal_myocardial_fiber0.63640504
93MP0002282_abnormal_trachea_morphology0.63066281
94MP0002272_abnormal_nervous_system0.62443820
95MP0009250_abnormal_appendicular_skeleto0.61910304
96MP0003122_maternal_imprinting0.61635784
97MP0000955_abnormal_spinal_cord0.61512193
98MP0002088_abnormal_embryonic_growth/wei0.61069897
99MP0002067_abnormal_sensory_capabilities0.60903882
100MP0005379_endocrine/exocrine_gland_phen0.59212662

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.17277150
2Septo-optic dysplasia (HP:0100842)3.98582076
3Severe visual impairment (HP:0001141)3.54571193
4Chronic hepatic failure (HP:0100626)3.33352112
5Tubulointerstitial nephritis (HP:0001970)3.12556068
6Meckel diverticulum (HP:0002245)3.02830291
7Colon cancer (HP:0003003)2.95745747
8Abnormality of the ileum (HP:0001549)2.90790972
9Abnormality of methionine metabolism (HP:0010901)2.88890488
10Abnormality of homocysteine metabolism (HP:0010919)2.84626038
11Homocystinuria (HP:0002156)2.84626038
12Bilateral microphthalmos (HP:0007633)2.83193224
13Absent/shortened dynein arms (HP:0200106)2.77497188
14Dynein arm defect of respiratory motile cilia (HP:0012255)2.77497188
15Abnormality of aspartate family amino acid metabolism (HP:0010899)2.72017152
16Birth length less than 3rd percentile (HP:0003561)2.71947380
17Optic nerve hypoplasia (HP:0000609)2.71347648
18Impulsivity (HP:0100710)2.70624285
19Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.70447527
20Chronic bronchitis (HP:0004469)2.61635887
21Maternal diabetes (HP:0009800)2.58810582
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.53896326
23Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.53556622
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.52742254
25Embryonal renal neoplasm (HP:0011794)2.49723171
26Abnormal respiratory motile cilium physiology (HP:0012261)2.48380272
27Glioma (HP:0009733)2.47148842
28Abnormality of sulfur amino acid metabolism (HP:0004339)2.43493182
29Ependymoma (HP:0002888)2.43249719
30Aplasia/Hypoplasia of the earlobes (HP:0009906)2.42718608
31Multiple enchondromatosis (HP:0005701)2.42099624
32Nephroblastoma (Wilms tumor) (HP:0002667)2.41867964
33Small intestinal stenosis (HP:0012848)2.39413964
34Duodenal stenosis (HP:0100867)2.39413964
35Medulloblastoma (HP:0002885)2.39297824
36Attenuation of retinal blood vessels (HP:0007843)2.39140394
37Rhabdomyosarcoma (HP:0002859)2.38008216
38Myelomeningocele (HP:0002475)2.37066544
39Chromsome breakage (HP:0040012)2.37044256
40Abnormality of chromosome stability (HP:0003220)2.36255453
41Pendular nystagmus (HP:0012043)2.33645712
42Abnormal ciliary motility (HP:0012262)2.30993986
43Abnormal lung lobation (HP:0002101)2.29060810
44Aplasia/Hypoplasia of the sacrum (HP:0008517)2.27787121
45Hypoalphalipoproteinemia (HP:0003233)2.27226355
46Abnormality of the duodenum (HP:0002246)2.21214328
47Bony spicule pigmentary retinopathy (HP:0007737)2.19953374
48Sloping forehead (HP:0000340)2.19498868
49Progressive sensorineural hearing impairment (HP:0000408)2.19294872
50Abnormal spermatogenesis (HP:0008669)2.18112464
51Abnormality of macular pigmentation (HP:0008002)2.13407335
52Megaloblastic anemia (HP:0001889)2.11568020
53Abnormality of the preputium (HP:0100587)2.11514684
54Abnormality of the parathyroid morphology (HP:0011766)2.10093188
55Abnormal respiratory epithelium morphology (HP:0012253)2.09858970
56Abnormal respiratory motile cilium morphology (HP:0005938)2.09858970
57Abnormality of serum amino acid levels (HP:0003112)2.09720561
58Absent septum pellucidum (HP:0001331)2.09256959
59Resting tremor (HP:0002322)2.04782726
60Esophageal atresia (HP:0002032)2.01392362
61Hyperglycinuria (HP:0003108)2.00285842
62Hyperkalemia (HP:0002153)1.99555215
63Infertility (HP:0000789)1.98679718
64Abnormality of the septum pellucidum (HP:0007375)1.98654378
65Neoplasm of striated muscle (HP:0009728)1.97153453
66Bifid tongue (HP:0010297)1.95899055
67Pancreatic fibrosis (HP:0100732)1.95122600
68Methylmalonic acidemia (HP:0002912)1.94118636
69Astrocytoma (HP:0009592)1.92000338
70Abnormality of the astrocytes (HP:0100707)1.92000338
71Abnormality of the carotid arteries (HP:0005344)1.90702467
72Abnormality of glycine metabolism (HP:0010895)1.90543761
73Abnormality of serine family amino acid metabolism (HP:0010894)1.90543761
74Anencephaly (HP:0002323)1.90118134
75Aplastic anemia (HP:0001915)1.88164635
76Abnormality of DNA repair (HP:0003254)1.88154037
77Pancreatic islet-cell hyperplasia (HP:0004510)1.87819348
78Gastrointestinal atresia (HP:0002589)1.86164446
79Aplasia/Hypoplasia of the sternum (HP:0006714)1.85724910
80Renal Fanconi syndrome (HP:0001994)1.85629320
81Rhinitis (HP:0012384)1.84469383
82Neoplasm of the oral cavity (HP:0100649)1.83948837
83Abnormality of abdominal situs (HP:0011620)1.83919088
84Abdominal situs inversus (HP:0003363)1.83919088
85Azoospermia (HP:0000027)1.83902627
86Selective tooth agenesis (HP:0001592)1.83536054
87Horizontal nystagmus (HP:0000666)1.82003820
88Myokymia (HP:0002411)1.81447803
89Abnormal number of incisors (HP:0011064)1.80925788
90Breast aplasia (HP:0100783)1.80165370
91Growth hormone deficiency (HP:0000824)1.79558272
92Scotoma (HP:0000575)1.78891448
93Sclerocornea (HP:0000647)1.78847009
94Cortical dysplasia (HP:0002539)1.75276791
95Renovascular hypertension (HP:0100817)1.74562091
96Hyperglycinemia (HP:0002154)1.72331691
97Choanal stenosis (HP:0000452)1.71786829
98Intestinal atresia (HP:0011100)1.71748198
99Pancreatic cysts (HP:0001737)1.71539179
100Aplasia/Hypoplasia of the breasts (HP:0010311)1.71032569

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK46.06128388
2TSSK64.21778315
3PNCK4.05890885
4BUB13.06479496
5CDC73.05592635
6MKNK22.76491866
7TTK2.71673529
8PLK22.47402349
9TNIK2.47387466
10PBK2.47315901
11PDK22.40093686
12MKNK12.14713773
13PLK32.14633698
14INSRR2.11730228
15WEE11.98652957
16VRK21.89324288
17ZAK1.84214928
18NEK61.83683019
19SRPK11.83130735
20BRD41.72719911
21MAP4K21.65184772
22BMPR1B1.63225667
23TAF11.60358163
24STK38L1.60070725
25MST41.49489624
26TESK11.44704674
27ERBB41.44221590
28ACVR1B1.43092805
29VRK11.38743530
30TRIM281.38119372
31PLK11.33776368
32NME11.29296017
33DDR21.24106332
34WNK31.21204978
35BRSK21.19057396
36TYRO31.12405461
37CDK71.11190688
38NEK11.09206875
39EIF2AK31.05215688
40DYRK21.01904319
41TIE10.95537761
42DYRK30.91948375
43NUAK10.87038200
44MAPK150.85670640
45CAMK1G0.82712639
46STK160.81279341
47PRKD30.79958317
48BRSK10.79361876
49BRAF0.76204804
50ALK0.75453484
51PASK0.74702345
52MAP3K90.73371471
53NEK20.69688839
54FGFR10.68592005
55CHEK20.66805353
56STK380.62127695
57ATR0.56877775
58CDK30.56580221
59PRKCG0.55733084
60CDK190.54862949
61WNK40.52851974
62CDK10.52398400
63CHEK10.51160199
64WNK10.49865327
65TGFBR10.48540459
66MAP3K80.47965962
67ATM0.47902238
68CDK20.47636615
69OXSR10.46983316
70CSNK1G10.45357942
71EIF2AK20.45339844
72MAP3K100.45052638
73LATS20.44721289
74AURKB0.44492910
75PRKG20.42977527
76PRKDC0.35546896
77CSNK1E0.34435877
78CSNK2A20.32001375
79PIK3CG0.31159969
80CDK120.30725954
81FLT30.26894457
82UHMK10.26298191
83CSNK2A10.25114104
84STK40.24532978
85GSK3B0.24221575
86PRKG10.23975718
87CASK0.21977535
88EIF2AK10.21407044
89AKT30.20373849
90FRK0.19669929
91PRKCI0.19525607
92CSNK1A10.19151856
93PAK10.19105017
94PAK40.18898053
95STK390.18120968
96RPS6KA10.17358725
97MOS0.17008779
98STK30.16344518
99AURKA0.16051755
100CAMK2A0.16042612

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.02835603
2Proteasome_Homo sapiens_hsa030503.36967749
3Mismatch repair_Homo sapiens_hsa034303.16080405
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.79119288
5DNA replication_Homo sapiens_hsa030302.72536528
6RNA transport_Homo sapiens_hsa030132.61131264
7Non-homologous end-joining_Homo sapiens_hsa034502.37287235
8RNA polymerase_Homo sapiens_hsa030202.36601422
9Base excision repair_Homo sapiens_hsa034102.00194673
10Homologous recombination_Homo sapiens_hsa034401.97166559
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.96910097
12Spliceosome_Homo sapiens_hsa030401.95125894
13One carbon pool by folate_Homo sapiens_hsa006701.91861460
14Selenocompound metabolism_Homo sapiens_hsa004501.88333759
15Nucleotide excision repair_Homo sapiens_hsa034201.81157471
16Vitamin B6 metabolism_Homo sapiens_hsa007501.80620298
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.80597046
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.76644313
19Pyruvate metabolism_Homo sapiens_hsa006201.74934435
20Biosynthesis of amino acids_Homo sapiens_hsa012301.74723410
21Cell cycle_Homo sapiens_hsa041101.73962664
22Protein export_Homo sapiens_hsa030601.70369031
23Fatty acid biosynthesis_Homo sapiens_hsa000611.68713176
24Fanconi anemia pathway_Homo sapiens_hsa034601.65831751
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.65279420
26Basal transcription factors_Homo sapiens_hsa030221.63444086
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59998822
28Propanoate metabolism_Homo sapiens_hsa006401.56780334
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.56435470
30Butanoate metabolism_Homo sapiens_hsa006501.54208634
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49421976
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.48037721
33Huntingtons disease_Homo sapiens_hsa050161.47410297
34RNA degradation_Homo sapiens_hsa030181.44591759
35Ribosome_Homo sapiens_hsa030101.41500249
36Olfactory transduction_Homo sapiens_hsa047401.41353415
37Oxidative phosphorylation_Homo sapiens_hsa001901.40325200
38Parkinsons disease_Homo sapiens_hsa050121.37430263
39mRNA surveillance pathway_Homo sapiens_hsa030151.35443284
40Steroid biosynthesis_Homo sapiens_hsa001001.35349882
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28410123
42Purine metabolism_Homo sapiens_hsa002301.22782061
43Carbon metabolism_Homo sapiens_hsa012001.16910304
44Folate biosynthesis_Homo sapiens_hsa007901.14983961
45Fatty acid metabolism_Homo sapiens_hsa012121.12530050
46Pyrimidine metabolism_Homo sapiens_hsa002401.09811402
47Oocyte meiosis_Homo sapiens_hsa041141.08062911
48Fatty acid degradation_Homo sapiens_hsa000711.03368556
49Fatty acid elongation_Homo sapiens_hsa000621.02560474
50Cardiac muscle contraction_Homo sapiens_hsa042600.92492588
51Taste transduction_Homo sapiens_hsa047420.85948473
52Arginine and proline metabolism_Homo sapiens_hsa003300.85365855
53Glutathione metabolism_Homo sapiens_hsa004800.84133230
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81445822
55Nicotine addiction_Homo sapiens_hsa050330.77072957
56Alzheimers disease_Homo sapiens_hsa050100.71665689
57Tight junction_Homo sapiens_hsa045300.70008423
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68898690
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68880439
60Vitamin digestion and absorption_Homo sapiens_hsa049770.66686752
61Metabolic pathways_Homo sapiens_hsa011000.61454745
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61293832
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61068794
64Basal cell carcinoma_Homo sapiens_hsa052170.59387775
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59259048
66Caffeine metabolism_Homo sapiens_hsa002320.56322479
67Wnt signaling pathway_Homo sapiens_hsa043100.55199893
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55153747
69Hedgehog signaling pathway_Homo sapiens_hsa043400.54415825
70Nitrogen metabolism_Homo sapiens_hsa009100.53576092
71Phototransduction_Homo sapiens_hsa047440.52561726
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52201678
73p53 signaling pathway_Homo sapiens_hsa041150.51877451
74Arginine biosynthesis_Homo sapiens_hsa002200.50800036
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50491070
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49758498
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44497508
78Sulfur relay system_Homo sapiens_hsa041220.42396823
79Retinol metabolism_Homo sapiens_hsa008300.42292432
80Hippo signaling pathway_Homo sapiens_hsa043900.40244155
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40222771
82beta-Alanine metabolism_Homo sapiens_hsa004100.40176635
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39999734
84Adherens junction_Homo sapiens_hsa045200.39843083
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33835109
86Lysine degradation_Homo sapiens_hsa003100.32974489
87Peroxisome_Homo sapiens_hsa041460.32943165
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.32596077
89Tryptophan metabolism_Homo sapiens_hsa003800.32013842
90TGF-beta signaling pathway_Homo sapiens_hsa043500.30108598
91Galactose metabolism_Homo sapiens_hsa000520.26231370
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25773722
93Thyroid cancer_Homo sapiens_hsa052160.25712223
94Protein digestion and absorption_Homo sapiens_hsa049740.25320936
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24592499
96Renin-angiotensin system_Homo sapiens_hsa046140.23762147
97GABAergic synapse_Homo sapiens_hsa047270.23457682
98Fat digestion and absorption_Homo sapiens_hsa049750.22919657
99Glutamatergic synapse_Homo sapiens_hsa047240.19711501
100Epstein-Barr virus infection_Homo sapiens_hsa051690.18468737

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