C1ORF87

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1left/right pattern formation (GO:0060972)9.19802347
2regulation of cilium movement (GO:0003352)8.38039529
3primary alcohol catabolic process (GO:0034310)7.33952962
4left/right axis specification (GO:0070986)7.32776004
5ventricular system development (GO:0021591)7.08138716
6microtubule bundle formation (GO:0001578)6.63077462
7vitamin transmembrane transport (GO:0035461)6.58524820
8intraciliary transport (GO:0042073)6.19535139
9ethanol metabolic process (GO:0006067)6.09058075
10cilium organization (GO:0044782)6.04400623
11diterpenoid biosynthetic process (GO:0016102)5.83435085
12cilium assembly (GO:0042384)5.81329306
13response to xenobiotic stimulus (GO:0009410)5.52883855
14tolerance induction (GO:0002507)5.15831036
15centriole assembly (GO:0098534)5.04966352
16pyrimidine-containing compound transmembrane transport (GO:0072531)5.04500421
17one-carbon compound transport (GO:0019755)4.86574974
18regulation of microtubule-based movement (GO:0060632)4.83578668
19regulation of interleukin-5 production (GO:0032674)4.82153787
20protein localization to cilium (GO:0061512)4.80368223
21microtubule-based movement (GO:0007018)4.78960599
22cellular component assembly involved in morphogenesis (GO:0010927)4.67844423
23lung epithelium development (GO:0060428)4.67119993
24negative regulation of T cell differentiation in thymus (GO:0033085)4.54953451
25ethanol oxidation (GO:0006069)4.54703223
26negative regulation of B cell mediated immunity (GO:0002713)4.48022383
27negative regulation of immunoglobulin mediated immune response (GO:0002890)4.48022383
28sperm capacitation (GO:0048240)4.47815795
29establishment of apical/basal cell polarity (GO:0035089)4.39226652
30negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.38757132
31negative regulation of humoral immune response (GO:0002921)4.37656072
32glomerular epithelial cell development (GO:0072310)4.34958589
33regulation of interleukin-13 production (GO:0032656)4.31777167
34cell projection assembly (GO:0030031)4.27714131
35cilium morphogenesis (GO:0060271)4.20420991
36positive regulation of tolerance induction (GO:0002645)4.12417702
37microtubule depolymerization (GO:0007019)4.11870140
38regulation of germinal center formation (GO:0002634)4.09318052
39terpenoid biosynthetic process (GO:0016114)3.97647191
40retinoic acid metabolic process (GO:0042573)3.96985804
41establishment or maintenance of monopolar cell polarity (GO:0061339)3.81738568
42establishment of monopolar cell polarity (GO:0061162)3.81738568
43lateral ventricle development (GO:0021670)3.80142889
44nucleoside diphosphate phosphorylation (GO:0006165)3.79261518
45microtubule polymerization or depolymerization (GO:0031109)3.73397333
46cytoplasmic microtubule organization (GO:0031122)3.70800032
47negative regulation of inclusion body assembly (GO:0090084)3.46640249
48exogenous drug catabolic process (GO:0042738)3.43362157
49retinal rod cell development (GO:0046548)3.35836557
50establishment of planar polarity (GO:0001736)3.29212878
51establishment of tissue polarity (GO:0007164)3.29212878
52O-glycan processing (GO:0016266)3.25413495
53primary alcohol metabolic process (GO:0034308)3.16984294
54glutathione derivative metabolic process (GO:1901685)3.13518655
55glutathione derivative biosynthetic process (GO:1901687)3.13518655
56regulation of tolerance induction (GO:0002643)3.08682282
57retinol metabolic process (GO:0042572)3.05115738
58positive regulation of smoothened signaling pathway (GO:0045880)3.00755567
59axonemal dynein complex assembly (GO:0070286)21.9061385
60hydrogen peroxide biosynthetic process (GO:0050665)2.98373352
61determination of left/right symmetry (GO:0007368)2.96092180
62sperm motility (GO:0030317)2.94675023
63phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.89065497
64centriole replication (GO:0007099)2.85350387
65regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.85146656
66determination of bilateral symmetry (GO:0009855)2.83343056
67lateral sprouting from an epithelium (GO:0060601)2.81871565
68aldehyde catabolic process (GO:0046185)2.80813441
69microtubule-based process (GO:0007017)2.80018706
70multicellular organismal water homeostasis (GO:0050891)2.79988909
71specification of symmetry (GO:0009799)2.76650355
72carnitine metabolic process (GO:0009437)2.75588000
73drug catabolic process (GO:0042737)2.73738491
74regulation of microtubule depolymerization (GO:0031114)2.72770543
75retinal cone cell development (GO:0046549)2.65329762
76apical protein localization (GO:0045176)2.63923881
77reactive oxygen species biosynthetic process (GO:1903409)2.63823146
78excretion (GO:0007588)2.61386379
79hypotonic response (GO:0006971)2.58839813
80progesterone metabolic process (GO:0042448)2.57395413
81smoothened signaling pathway (GO:0007224)2.56628838
82organelle assembly (GO:0070925)2.56628004
83phosphatidylcholine biosynthetic process (GO:0006656)2.51867830
84CDP-diacylglycerol biosynthetic process (GO:0016024)2.50530983
85photoreceptor cell maintenance (GO:0045494)2.49550577
86calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.47480089
87regulation of response to osmotic stress (GO:0047484)2.47137651
88hydrogen peroxide catabolic process (GO:0042744)2.46223154
89heart looping (GO:0001947)2.43929138
90regulation of autophagic vacuole assembly (GO:2000785)2.42904770
91dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.42127395
92water homeostasis (GO:0030104)2.39559929
93sodium ion homeostasis (GO:0055078)2.36312377
94protein O-linked glycosylation (GO:0006493)2.33850063
95cilium or flagellum-dependent cell motility (GO:0001539)19.2798357
96cilium movement (GO:0003341)16.2828017
97motile cilium assembly (GO:0044458)15.2577091
98epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)15.1698848
99epithelial cilium movement (GO:0003351)13.7115867
100axoneme assembly (GO:0035082)10.7508681

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.02566267
2DROSHA_22980978_ChIP-Seq_HELA_Human3.46389955
3FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.43302017
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.10533857
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.90775647
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.75728214
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.54728847
8ESR1_20079471_ChIP-ChIP_T-47D_Human2.29572928
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.10687769
10AHR_22903824_ChIP-Seq_MCF-7_Human1.93445414
11STAT1_20625510_ChIP-Seq_HELA_Human1.81787737
12FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.81189680
13TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.77229924
14ESR2_21235772_ChIP-Seq_MCF-7_Human1.74954380
15ESR1_21235772_ChIP-Seq_MCF-7_Human1.73152058
16SOX2_27498859_Chip-Seq_STOMACH_Mouse1.72497953
17FOXM1_26456572_ChIP-Seq_MCF-7_Human1.71543341
18ARNT_22903824_ChIP-Seq_MCF-7_Human1.70308692
19RUNX1_27514584_Chip-Seq_MCF-7_Human1.68558537
20VDR_22108803_ChIP-Seq_LS180_Human1.66886902
21TP63_23658742_ChIP-Seq_EP156T_Human1.66117571
22SMC4_20622854_ChIP-Seq_HELA_Human1.65409062
23* PIAS1_25552417_ChIP-Seq_VCAP_Human1.62783831
24PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.54809825
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54465477
26ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.52694465
27* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.52173156
28NR3C1_21868756_ChIP-Seq_MCF10A_Human1.51660824
29AR_21572438_ChIP-Seq_LNCaP_Human1.47807454
30TDRD3_21172665_ChIP-Seq_MCF-7_Human1.46888650
31KLF5_25053715_ChIP-Seq_YYC3_Human1.46146583
32CTNNB1_20460455_ChIP-Seq_HCT116_Human1.41816792
33SOX9_24532713_ChIP-Seq_HFSC_Mouse1.41373939
34TP63_22573176_ChIP-Seq_HFKS_Human1.41365489
35GATA1_19941826_ChIP-Seq_K562_Human1.41337131
36P63_26484246_Chip-Seq_KERATINOCYTES_Human1.40456594
37FOXA1_25552417_ChIP-Seq_VCAP_Human1.37647227
38SMRT_27268052_Chip-Seq_Bcells_Human1.37551765
39SOX2_20726797_ChIP-Seq_SW620_Human1.36271469
40RAD21_21589869_ChIP-Seq_MESCs_Mouse1.33883737
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33309946
42CDX2_20551321_ChIP-Seq_CACO-2_Human1.32624147
43* ETV1_20927104_ChIP-Seq_GIST48_Human1.32376723
44TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.30856662
45CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28919942
46TP53_18474530_ChIP-ChIP_U2OS_Human1.27634405
47* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.24503946
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23097548
49KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20860042
50SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20531928
51ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.20504190
52* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.19237541
53GATA4_25053715_ChIP-Seq_YYC3_Human1.18829461
54FOXO3_23340844_ChIP-Seq_DLD1_Human1.18586109
55* HNFA_21074721_ChIP-Seq_CACO-2_Human1.18027581
56* PHF8_20622853_ChIP-Seq_HELA_Human1.16233826
57FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.15759431
58* RBPJ_21746931_ChIP-Seq_IB4_Human1.11913407
59ELF1_20517297_ChIP-Seq_JURKAT_Human1.11806478
60SMAD3_21741376_ChIP-Seq_HESCs_Human1.11311085
61PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10825168
62* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07224495
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05996887
64YY1_22570637_ChIP-Seq_MALME-3M_Human1.05639115
65CTCF_20526341_ChIP-Seq_ESCs_Human1.05375111
66CEBPB_22108803_ChIP-Seq_LS180_Human1.05013741
67CTCF_27219007_Chip-Seq_Bcells_Human1.04978141
68GATA2_19941826_ChIP-Seq_K562_Human1.03191666
69* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.02908192
70FOXA2_19822575_ChIP-Seq_HepG2_Human1.02192331
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01688963
72* NFYA_21822215_ChIP-Seq_K562_Human1.00176863
73GATA3_24758297_ChIP-Seq_MCF-7_Human0.99748370
74P68_20966046_ChIP-Seq_HELA_Human0.99251974
75* SMAD4_21799915_ChIP-Seq_A2780_Human0.99016460
76* GATA6_21074721_ChIP-Seq_CACO-2_Human0.98071097
77P300_27268052_Chip-Seq_Bcells_Human0.94898879
78TP53_16413492_ChIP-PET_HCT116_Human0.94060764
79* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94010330
80FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.92862791
81PHF8_20622854_ChIP-Seq_HELA_Human0.92675851
82TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92220853
83* NFYB_21822215_ChIP-Seq_K562_Human0.90906425
84RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90355241
85CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89928782
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88622743
87EZH2_27294783_Chip-Seq_ESCs_Mouse0.88350995
88BCAT_22108803_ChIP-Seq_LS180_Human0.88209488
89SMAD4_21741376_ChIP-Seq_EPCs_Human0.88096407
90CREB1_26743006_Chip-Seq_LNCaP_Human0.87924990
91EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87887213
92WDR5_24793694_ChIP-Seq_LNCAP_Human0.87800485
93VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.87575084
94* TBL1_22424771_ChIP-Seq_293T_Human0.87294909
95EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87199032
96CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87128342
97SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86701786
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86106480
99AR_20517297_ChIP-Seq_VCAP_Human0.85871732
100SOX2_21211035_ChIP-Seq_LN229_Human0.84695695

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology7.18459973
2MP0008875_abnormal_xenobiotic_pharmacok7.16740291
3MP0002132_abnormal_respiratory_system5.76922201
4MP0002277_abnormal_respiratory_mucosa4.07691117
5MP0005623_abnormal_meninges_morphology3.97447339
6MP0001984_abnormal_olfaction3.85139036
7MP0004043_abnormal_pH_regulation3.76197390
8MP0009780_abnormal_chondrocyte_physiolo3.53990982
9MP0004133_heterotaxia3.29821395
10MP0008789_abnormal_olfactory_epithelium2.99927709
11MP0000383_abnormal_hair_follicle2.41589741
12MP0000566_synostosis2.31729905
13MP0003878_abnormal_ear_physiology2.20873445
14MP0005377_hearing/vestibular/ear_phenot2.20873445
15MP0005083_abnormal_biliary_tract2.12120678
16MP0002168_other_aberrant_phenotype2.09569928
17MP0010678_abnormal_skin_adnexa2.04727351
18MP0002282_abnormal_trachea_morphology1.98538001
19MP0004019_abnormal_vitamin_homeostasis1.93613118
20MP0003656_abnormal_erythrocyte_physiolo1.91811355
21MP0001765_abnormal_ion_homeostasis1.89258457
22MP0005499_abnormal_olfactory_system1.86643655
23MP0005394_taste/olfaction_phenotype1.86643655
24MP0002160_abnormal_reproductive_system1.79422173
25MP0001346_abnormal_lacrimal_gland1.77488562
26MP0000678_abnormal_parathyroid_gland1.67755025
27MP0000465_gastrointestinal_hemorrhage1.45915109
28MP0005165_increased_susceptibility_to1.39724223
29MP0002909_abnormal_adrenal_gland1.37823665
30MP0010155_abnormal_intestine_physiology1.36290433
31MP0005395_other_phenotype1.32146961
32MP0005636_abnormal_mineral_homeostasis1.27518137
33MP0002249_abnormal_larynx_morphology1.22921092
34MP0005248_abnormal_Harderian_gland1.21842161
35MP0003303_peritoneal_inflammation1.12298060
36MP0002876_abnormal_thyroid_physiology1.08919538
37MP0009379_abnormal_foot_pigmentation1.03232617
38MP0002735_abnormal_chemical_nociception0.97907637
39MP0010234_abnormal_vibrissa_follicle0.97480604
40MP0002734_abnormal_mechanical_nocicepti0.96932568
41MP0005365_abnormal_bile_salt0.93568382
42MP0009643_abnormal_urine_homeostasis0.92693285
43MP0001485_abnormal_pinna_reflex0.91943285
44MP0000681_abnormal_thyroid_gland0.88873709
45MP0005085_abnormal_gallbladder_physiolo0.88817590
46MP0002233_abnormal_nose_morphology0.88045135
47MP0003136_yellow_coat_color0.85477478
48MP0002136_abnormal_kidney_physiology0.85223384
49MP0005164_abnormal_response_to0.84331722
50MP0010030_abnormal_orbit_morphology0.82703937
51MP0008004_abnormal_stomach_pH0.82213385
52MP0005389_reproductive_system_phenotype0.80001922
53MP0004883_abnormal_blood_vessel0.78655851
54MP0005464_abnormal_platelet_physiology0.77322324
55MP0002638_abnormal_pupillary_reflex0.77187702
56MP0009765_abnormal_xenobiotic_induced0.75428494
57MP0003698_abnormal_male_reproductive0.73163443
58MP0004264_abnormal_extraembryonic_tissu0.72467725
59MP0009046_muscle_twitch0.71996284
60MP0001879_abnormal_lymphatic_vessel0.71517686
61MP0001929_abnormal_gametogenesis0.70875965
62MP0005310_abnormal_salivary_gland0.70660245
63MP0001849_ear_inflammation0.70410819
64MP0002405_respiratory_system_inflammati0.70106654
65MP0003453_abnormal_keratinocyte_physiol0.69302157
66MP0005220_abnormal_exocrine_pancreas0.67578435
67MP0002098_abnormal_vibrissa_morphology0.66691873
68MP0009763_increased_sensitivity_to0.65919107
69MP0003866_abnormal_defecation0.65785323
70MP0005408_hypopigmentation0.62367833
71MP0005646_abnormal_pituitary_gland0.60742916
72MP0001790_abnormal_immune_system0.59650775
73MP0005387_immune_system_phenotype0.59650775
74MP0005253_abnormal_eye_physiology0.59169586
75MP0000858_altered_metastatic_potential0.57552003
76MP0001663_abnormal_digestive_system0.56598471
77MP0003045_fibrosis0.56143187
78MP0003075_altered_response_to0.55953998
79MP0000026_abnormal_inner_ear0.55815694
80MP0005503_abnormal_tendon_morphology0.55455137
81MP0006082_CNS_inflammation0.54449134
82MP0001324_abnormal_eye_pigmentation0.53801354
83MP0001664_abnormal_digestion0.53674621
84MP0003890_abnormal_embryonic-extraembry0.53458251
85MP0008872_abnormal_physiological_respon0.53117703
86MP0000467_abnormal_esophagus_morphology0.50804951
87MP0002139_abnormal_hepatobiliary_system0.50103994
88MP0005551_abnormal_eye_electrophysiolog0.49405707
89MP0002133_abnormal_respiratory_system0.48504821
90MP0005388_respiratory_system_phenotype0.48504821
91MP0001293_anophthalmia0.48213995
92MP0001970_abnormal_pain_threshold0.47967707
93MP0005409_darkened_coat_color0.47682614
94MP0002135_abnormal_kidney_morphology0.45502822
95MP0001270_distended_abdomen0.44841875
96MP0005023_abnormal_wound_healing0.44536386
97MP0001944_abnormal_pancreas_morphology0.43052665
98MP0002229_neurodegeneration0.42539462
99MP0002116_abnormal_craniofacial_bone0.42190210
100MP0001502_abnormal_circadian_rhythm0.41854746

Predicted human phenotypes

RankGene SetZ-score
1Chronic bronchitis (HP:0004469)7.98174656
2Bronchiectasis (HP:0002110)7.48524595
3Nasal polyposis (HP:0100582)6.80912370
4Abnormality of the nasal mucosa (HP:0000433)5.66140144
5Bronchitis (HP:0012387)4.53037215
6Recurrent sinusitis (HP:0011108)4.51297502
7Infertility (HP:0000789)4.24276866
8Chronic sinusitis (HP:0011109)4.08429337
9Recurrent otitis media (HP:0000403)3.95326052
10Male infertility (HP:0003251)3.89648935
11Occipital encephalocele (HP:0002085)3.52287618
12Pancreatic fibrosis (HP:0100732)3.38724306
13True hermaphroditism (HP:0010459)3.23137927
14Hyperactive renin-angiotensin system (HP:0000841)3.06534788
15Chronic otitis media (HP:0000389)3.00432264
16Atelectasis (HP:0100750)2.96941892
17Cystic liver disease (HP:0006706)2.77380319
18Molar tooth sign on MRI (HP:0002419)2.74465444
19Abnormality of midbrain morphology (HP:0002418)2.74465444
20Pancreatic cysts (HP:0001737)2.74125774
21Chronic hepatic failure (HP:0100626)2.70650376
22Nephronophthisis (HP:0000090)2.65957045
23Tubulointerstitial nephritis (HP:0001970)2.35302183
24Postaxial foot polydactyly (HP:0001830)2.33245375
25Recurrent bronchitis (HP:0002837)2.15755225
26Abnormality of the renal medulla (HP:0100957)2.09061199
27Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.5344623
28Abnormal respiratory epithelium morphology (HP:0012253)11.3059099
29Abnormal respiratory motile cilium morphology (HP:0005938)11.3059099
30Dynein arm defect of respiratory motile cilia (HP:0012255)11.2075221
31Absent/shortened dynein arms (HP:0200106)11.2075221
32Abnormal respiratory motile cilium physiology (HP:0012261)11.1165134
33Abnormal ciliary motility (HP:0012262)10.9684064
34Rhinitis (HP:0012384)10.1177555
35Bell-shaped thorax (HP:0001591)1.99906278
36Congenital hepatic fibrosis (HP:0002612)1.99646423
37Decreased circulating renin level (HP:0003351)1.94538314
38Anencephaly (HP:0002323)1.89230180
39Aplasia/Hypoplasia of the tongue (HP:0010295)1.86664469
40Renal salt wasting (HP:0000127)1.84505633
41Male pseudohermaphroditism (HP:0000037)1.83355685
42Absent frontal sinuses (HP:0002688)1.81506662
43Absent rod-and cone-mediated responses on ERG (HP:0007688)1.79194102
44Medial flaring of the eyebrow (HP:0010747)1.76869354
45Hyperkalemia (HP:0002153)1.67511137
46Tubular atrophy (HP:0000092)1.67011708
47Asplenia (HP:0001746)1.66334373
48Aplasia/Hypoplasia of the spleen (HP:0010451)1.64811959
49Congenital primary aphakia (HP:0007707)1.64460154
50Nephropathy (HP:0000112)1.63631973
51Gait imbalance (HP:0002141)1.61419056
52Oculomotor apraxia (HP:0000657)1.57496249
53Furrowed tongue (HP:0000221)1.56709512
54Sclerocornea (HP:0000647)1.53818762
55Hyperaldosteronism (HP:0000859)1.53417664
56Postaxial hand polydactyly (HP:0001162)1.46267172
57Nephrogenic diabetes insipidus (HP:0009806)1.42110766
58Abnormality of renin-angiotensin system (HP:0000847)1.39752391
59Abnormality of chloride homeostasis (HP:0011422)1.37002213
60Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.36888393
61Hypokalemic alkalosis (HP:0001949)1.32115088
62Median cleft lip (HP:0000161)1.31678622
63Tubulointerstitial abnormality (HP:0001969)1.29918149
64Cone-rod dystrophy (HP:0000548)1.27127027
65Short thorax (HP:0010306)1.22972123
66Preaxial hand polydactyly (HP:0001177)1.21846796
67Abnormality of permanent molar morphology (HP:0011071)1.15887406
68Abnormality of the dental root (HP:0006486)1.15887406
69Taurodontia (HP:0000679)1.15887406
70Hyponatremia (HP:0002902)1.14198113
71Abnormal rod and cone electroretinograms (HP:0008323)1.14077612
72Abnormality of the distal phalanges of the toes (HP:0010182)1.13900743
73Glucose intolerance (HP:0000833)1.13087148
74Decreased central vision (HP:0007663)1.12646889
75Stage 5 chronic kidney disease (HP:0003774)1.12234206
76Poor coordination (HP:0002370)1.12110719
77Fetal akinesia sequence (HP:0001989)1.11920620
78Genital tract atresia (HP:0001827)1.11883574
79Vaginal atresia (HP:0000148)1.11508563
80Bifid scrotum (HP:0000048)1.11477076
81Hand muscle atrophy (HP:0009130)1.10609217
82Abnormality of the frontal sinuses (HP:0002687)1.10344265
83Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.08856569
84Short nail (HP:0001799)1.07821375
85Abnormality of molar (HP:0011077)1.05763995
86Abnormality of molar morphology (HP:0011070)1.05763995
87Abnormality of the dental pulp (HP:0006479)1.05399527
88Lip pit (HP:0100267)1.03785941
89Abnormality of monocarboxylic acid metabolism (HP:0010996)1.01449534
90Polydipsia (HP:0001959)0.99452365
91Abnormal drinking behavior (HP:0030082)0.99452365
92Muscle fiber splitting (HP:0003555)0.98987839
93Popliteal pterygium (HP:0009756)0.98758241
94Aplasia of the musculature (HP:0100854)0.98130900
95Retinitis pigmentosa (HP:0000510)0.96965291
96Supernumerary spleens (HP:0009799)0.96695153
97Short femoral neck (HP:0100864)0.96335133
98Obstructive sleep apnea (HP:0002870)0.94963508
99Purpura (HP:0000979)0.92941129
100Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)0.92601558

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST46.34521122
2EPHA24.74746078
3MAPKAPK32.24793227
4MAP3K22.11725423
5NME12.05797324
6STK242.04259948
7MAPK1511.3614256
8TTK1.73779875
9SMG11.68099782
10PTK2B1.67953435
11MAP3K31.65353039
12EEF2K1.63841256
13BCR1.63095295
14CSK1.58121588
15RIPK41.56798286
16STK101.28870080
17LRRK21.25674053
18EPHB11.20204152
19PNCK1.16777677
20MST1R1.16025756
21MAP3K71.07490406
22NEK61.06512077
23TLK11.01131970
24TRPM70.99837610
25EPHA30.92900155
26MARK20.91807906
27ERBB20.89569842
28STK380.87200219
29STK160.84995347
30CAMKK10.84361919
31LATS10.80853648
32PRKCI0.79671527
33TBK10.78208153
34TESK10.78042179
35STK38L0.75492690
36BRSK20.75275854
37IRAK10.62402815
38NLK0.56961725
39MAP3K120.56807967
40PDPK10.55562527
41GRK60.54702780
42ERBB30.54690397
43MYLK0.54033240
44ICK0.53446904
45PRKCQ0.52316849
46TAOK10.50283716
47PRKAA20.50006336
48PRKCD0.47652073
49CAMK2G0.45748598
50FER0.43026644
51AURKA0.42949670
52ZAP700.41100750
53HIPK20.39858464
54TYK20.38804901
55SGK10.36560100
56DYRK1B0.35721620
57CAMKK20.34366883
58TRIB30.34306879
59LMTK20.32852157
60CDC42BPA0.32247408
61ADRBK10.31036780
62INSRR0.30361910
63FRK0.28056503
64FYN0.26452141
65ABL10.24140451
66PRKACA0.23270270
67RPS6KB20.22785085
68PRKCA0.22571524
69ROCK20.22553109
70RIPK10.22107736
71PAK10.21055402
72TEC0.20755488
73OXSR10.20584274
74MAP2K20.20387439
75ROCK10.20130933
76FGFR30.19304970
77BTK0.19087069
78PDK10.19051483
79BLK0.18614443
80RPS6KA20.18403555
81STK30.18308745
82AKT20.17807473
83PBK0.17510925
84MET0.16871029
85SGK20.16683024
86ILK0.16639538
87GRK10.15933905
88DYRK1A0.15781888
89MATK0.15622728
90EGFR0.15296336
91SRC0.15289917
92MAP3K40.14576890
93MAP2K10.14408031
94NEK90.14003812
95BMPR20.13975202
96SGK4940.13004677
97SGK2230.13004677
98CAMK2A0.12625039
99STK110.12284880
100MAPKAPK50.11906403

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.62846988
2Phenylalanine metabolism_Homo sapiens_hsa003604.81797676
3Chemical carcinogenesis_Homo sapiens_hsa052044.56963598
4Histidine metabolism_Homo sapiens_hsa003404.52543521
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.39216432
6Tyrosine metabolism_Homo sapiens_hsa003503.82499012
7beta-Alanine metabolism_Homo sapiens_hsa004102.97999681
8Huntingtons disease_Homo sapiens_hsa050162.65264331
9Glutathione metabolism_Homo sapiens_hsa004802.59951526
10Retinol metabolism_Homo sapiens_hsa008302.32838925
11Caffeine metabolism_Homo sapiens_hsa002322.32088410
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.97809917
13Linoleic acid metabolism_Homo sapiens_hsa005911.97661501
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.87079639
15Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.87026282
16Sphingolipid metabolism_Homo sapiens_hsa006001.84859302
17ABC transporters_Homo sapiens_hsa020101.55113951
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51179743
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.51116377
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.51017288
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.44133298
22Tight junction_Homo sapiens_hsa045301.33707495
23Arachidonic acid metabolism_Homo sapiens_hsa005901.17445375
24Fatty acid degradation_Homo sapiens_hsa000711.17005002
25Salivary secretion_Homo sapiens_hsa049701.05782269
26Starch and sucrose metabolism_Homo sapiens_hsa005000.98674943
27Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98326646
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93227505
29Circadian rhythm_Homo sapiens_hsa047100.92835770
30Peroxisome_Homo sapiens_hsa041460.92185660
31Hematopoietic cell lineage_Homo sapiens_hsa046400.87909639
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82279115
33Leukocyte transendothelial migration_Homo sapiens_hsa046700.80527541
34Notch signaling pathway_Homo sapiens_hsa043300.75063054
35Drug metabolism - other enzymes_Homo sapiens_hsa009830.73842148
36Choline metabolism in cancer_Homo sapiens_hsa052310.72221867
37Adherens junction_Homo sapiens_hsa045200.71993036
38Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70220571
39Taste transduction_Homo sapiens_hsa047420.64191145
40Olfactory transduction_Homo sapiens_hsa047400.63988651
41Hepatitis C_Homo sapiens_hsa051600.63897643
42Glycerophospholipid metabolism_Homo sapiens_hsa005640.61751408
43Primary bile acid biosynthesis_Homo sapiens_hsa001200.58315707
44Complement and coagulation cascades_Homo sapiens_hsa046100.57183701
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56133052
46Collecting duct acid secretion_Homo sapiens_hsa049660.55880922
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55492946
48Hedgehog signaling pathway_Homo sapiens_hsa043400.52041148
49Phototransduction_Homo sapiens_hsa047440.43093123
50PPAR signaling pathway_Homo sapiens_hsa033200.41160421
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41114303
52Serotonergic synapse_Homo sapiens_hsa047260.38961433
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.37261637
54Pancreatic secretion_Homo sapiens_hsa049720.35655600
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35334808
56cAMP signaling pathway_Homo sapiens_hsa040240.33267420
57Amoebiasis_Homo sapiens_hsa051460.31884055
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31807210
59Nicotine addiction_Homo sapiens_hsa050330.31283978
60Basal cell carcinoma_Homo sapiens_hsa052170.30926951
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29896113
62Allograft rejection_Homo sapiens_hsa053300.28618973
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28539719
64Glycerolipid metabolism_Homo sapiens_hsa005610.27714554
65Vitamin digestion and absorption_Homo sapiens_hsa049770.27672601
66Type I diabetes mellitus_Homo sapiens_hsa049400.26136712
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26099490
68Calcium signaling pathway_Homo sapiens_hsa040200.26037309
69Autoimmune thyroid disease_Homo sapiens_hsa053200.25827372
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.24897429
71Arginine and proline metabolism_Homo sapiens_hsa003300.24665833
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23679981
73Graft-versus-host disease_Homo sapiens_hsa053320.22876868
74Dilated cardiomyopathy_Homo sapiens_hsa054140.22748511
75Asthma_Homo sapiens_hsa053100.22216339
76Lysosome_Homo sapiens_hsa041420.21676055
77Metabolic pathways_Homo sapiens_hsa011000.21336521
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.20906378
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20557276
80Tryptophan metabolism_Homo sapiens_hsa003800.19581388
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19515126
82Bile secretion_Homo sapiens_hsa049760.19401449
83Ovarian steroidogenesis_Homo sapiens_hsa049130.18998260
84Cocaine addiction_Homo sapiens_hsa050300.18756791
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18745999
86Phagosome_Homo sapiens_hsa041450.18218691
87Hippo signaling pathway_Homo sapiens_hsa043900.17911717
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.15880435
89Insulin resistance_Homo sapiens_hsa049310.15368014
90Endocytosis_Homo sapiens_hsa041440.14916579
91Staphylococcus aureus infection_Homo sapiens_hsa051500.12959751
92Fatty acid biosynthesis_Homo sapiens_hsa000610.11315744
93Amphetamine addiction_Homo sapiens_hsa050310.10985617
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.10196630
95ECM-receptor interaction_Homo sapiens_hsa045120.10118092
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.10116619
97Antigen processing and presentation_Homo sapiens_hsa046120.09666848
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.08979385
99Gastric acid secretion_Homo sapiens_hsa049710.08413729
100Nitrogen metabolism_Homo sapiens_hsa009100.07611845

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