C1ORF61

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.27980771
2central nervous system myelination (GO:0022010)7.27980771
3neuronal stem cell maintenance (GO:0097150)6.52126350
4presynaptic membrane assembly (GO:0097105)6.40421443
5negative regulation of oligodendrocyte differentiation (GO:0048715)5.99726945
6postsynaptic membrane organization (GO:0001941)5.96867918
7neuron fate determination (GO:0048664)5.62261115
8presynaptic membrane organization (GO:0097090)5.41274350
9astrocyte differentiation (GO:0048708)5.06919508
10neuron cell-cell adhesion (GO:0007158)4.92217109
11heart valve formation (GO:0003188)4.84605633
12negative regulation of astrocyte differentiation (GO:0048712)4.80045160
13regulation of synapse structural plasticity (GO:0051823)4.79481743
14tongue development (GO:0043586)4.68374497
15prepulse inhibition (GO:0060134)4.44457937
16radial glial cell differentiation (GO:0060019)4.43654577
17negative regulation of glial cell differentiation (GO:0045686)4.42387577
18gamma-aminobutyric acid transport (GO:0015812)4.34109584
19pattern specification involved in kidney development (GO:0061004)4.19263338
20positive regulation of vascular permeability (GO:0043117)4.16144420
21negative regulation of inclusion body assembly (GO:0090084)4.11862225
22potassium ion import (GO:0010107)4.09769710
23dermatan sulfate biosynthetic process (GO:0030208)4.02479380
24auditory behavior (GO:0031223)3.99958894
25vocalization behavior (GO:0071625)3.96344493
26membrane repolarization (GO:0086009)3.92417082
27response to auditory stimulus (GO:0010996)3.87389845
28forebrain neuron differentiation (GO:0021879)3.86588060
29nephron tubule morphogenesis (GO:0072078)3.80851372
30nephron epithelium morphogenesis (GO:0072088)3.80851372
31cellular response to cholesterol (GO:0071397)3.79715682
32alanine transport (GO:0032328)3.74644249
33cell proliferation in forebrain (GO:0021846)3.69757217
34potassium ion export (GO:0071435)3.68054234
35otic vesicle formation (GO:0030916)3.65629853
36positive regulation of Notch signaling pathway (GO:0045747)3.63661393
37mechanosensory behavior (GO:0007638)3.62226282
38dermatan sulfate metabolic process (GO:0030205)3.60988888
39cell-cell signaling involved in cell fate commitment (GO:0045168)3.56898551
40regulation of inclusion body assembly (GO:0090083)3.50794427
41regulation of astrocyte differentiation (GO:0048710)3.50741808
42cGMP-mediated signaling (GO:0019934)3.50491369
43regulation of oligodendrocyte differentiation (GO:0048713)3.49827708
44oligodendrocyte differentiation (GO:0048709)3.47143291
45eye photoreceptor cell differentiation (GO:0001754)3.46832641
46photoreceptor cell differentiation (GO:0046530)3.46832641
47detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.44378522
48telencephalon development (GO:0021537)3.42296912
49negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.40057181
50limb bud formation (GO:0060174)3.39036543
51endocardial cushion morphogenesis (GO:0003203)3.35474103
52ionotropic glutamate receptor signaling pathway (GO:0035235)3.34342793
53neurotransmitter-gated ion channel clustering (GO:0072578)3.33115224
54cochlea development (GO:0090102)3.32807432
55pyrimidine nucleobase catabolic process (GO:0006208)3.27386138
56negative regulation of gliogenesis (GO:0014014)3.26920030
57L-amino acid import (GO:0043092)3.22567001
58regulation of fever generation (GO:0031620)3.20406780
59regulation of timing of cell differentiation (GO:0048505)3.19110179
60negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.16210223
61regulation of penile erection (GO:0060405)3.15490186
62regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.14135469
63glial cell differentiation (GO:0010001)3.10405713
64dendritic spine morphogenesis (GO:0060997)3.09913519
65membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.08854570
66nephron tubule formation (GO:0072079)3.08459682
67cellular potassium ion homeostasis (GO:0030007)3.06297931
68regulation of heat generation (GO:0031650)3.05067070
69axonal fasciculation (GO:0007413)3.04839656
70renal tubule morphogenesis (GO:0061333)3.04136524
71cranial nerve development (GO:0021545)3.03483325
72behavioral response to nicotine (GO:0035095)3.03317681
73neurotransmitter uptake (GO:0001504)3.02385616
74cell morphogenesis involved in neuron differentiation (GO:0048667)3.01968276
75nonmotile primary cilium assembly (GO:0035058)3.01563826
76positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.00593786
77cellular response to sterol (GO:0036315)2.94174443
78protein refolding (GO:0042026)2.94096731
79vascular smooth muscle contraction (GO:0014829)2.93909714
80positive regulation of synapse assembly (GO:0051965)2.93749391
81mesenchyme morphogenesis (GO:0072132)2.92764656
82developmental induction (GO:0031128)2.92705954
83negative regulation of neurotransmitter transport (GO:0051589)2.90376782
84axon regeneration (GO:0031103)2.90084345
85regulation of development, heterochronic (GO:0040034)2.89270542
86negative regulation of synaptic transmission, GABAergic (GO:0032229)2.87656743
87cerebellar granule cell differentiation (GO:0021707)2.87520087
88cell proliferation involved in metanephros development (GO:0072203)2.87256809
89neuronal action potential propagation (GO:0019227)2.87122446
90cilium movement (GO:0003341)2.85470679
91somite development (GO:0061053)2.84149353
92negative regulation of adenylate cyclase activity (GO:0007194)2.83721359
93epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.81771335
94auditory receptor cell differentiation (GO:0042491)2.79938853
95regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.79905122
96glutamate receptor signaling pathway (GO:0007215)2.79595185
97negative regulation of axon extension (GO:0030517)2.78827276
98amino acid import (GO:0043090)2.76278333
99Notch signaling involved in heart development (GO:0061314)2.75352614
100transmission of nerve impulse (GO:0019226)2.74683836

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.78696038
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.67630758
3GBX2_23144817_ChIP-Seq_PC3_Human3.08200873
4CBX2_27304074_Chip-Seq_ESCs_Mouse2.68784649
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.63338865
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.61866016
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.57917657
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.54240870
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.51893454
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.48413227
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.47525187
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43693663
13AR_21572438_ChIP-Seq_LNCaP_Human2.37892136
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.32921579
15RNF2_27304074_Chip-Seq_ESCs_Mouse2.28634472
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25913216
17ZNF274_21170338_ChIP-Seq_K562_Hela2.24582446
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.20556653
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16389925
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.15733461
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.15733461
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.15596028
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14639019
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08339228
25REST_21632747_ChIP-Seq_MESCs_Mouse2.07047459
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.06024711
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.01721654
28RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.99296824
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.79533184
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79244337
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.77977609
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.74569648
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.71338825
34SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70162983
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.67744869
36DROSHA_22980978_ChIP-Seq_HELA_Human1.64446015
37FUS_26573619_Chip-Seq_HEK293_Human1.62876611
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.61409579
39P300_19829295_ChIP-Seq_ESCs_Human1.60420652
40RNF2_27304074_Chip-Seq_NSC_Mouse1.59777868
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57784596
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55637810
43RING1B_27294783_Chip-Seq_ESCs_Mouse1.55431365
44IGF1R_20145208_ChIP-Seq_DFB_Human1.54267309
45TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.54133538
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54006355
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47046894
48TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45042652
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.42576900
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40868269
51RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.40274311
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39510050
53CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38517538
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.36503209
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36206401
56AR_25329375_ChIP-Seq_VCAP_Human1.36044064
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35802021
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35802021
59SMAD4_21799915_ChIP-Seq_A2780_Human1.34978710
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30928391
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29774974
62LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27543379
63EWS_26573619_Chip-Seq_HEK293_Human1.27345121
64EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26288182
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24086869
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21790452
67RING1B_27294783_Chip-Seq_NPCs_Mouse1.19381100
68TAF15_26573619_Chip-Seq_HEK293_Human1.18797794
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18010378
70* SOX2_21211035_ChIP-Seq_LN229_Gbm1.17858516
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17051806
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15955805
73YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15724502
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15327617
75VDR_22108803_ChIP-Seq_LS180_Human1.14657782
76RXR_22108803_ChIP-Seq_LS180_Human1.13538963
77TP53_20018659_ChIP-ChIP_R1E_Mouse1.12731774
78KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12269890
79RUNX2_22187159_ChIP-Seq_PCA_Human1.11320243
80* ER_23166858_ChIP-Seq_MCF-7_Human1.10889956
81STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10131683
82IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09531410
83STAT3_23295773_ChIP-Seq_U87_Human1.04199195
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.04038595
85SOX9_26525672_Chip-Seq_HEART_Mouse1.02476777
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01992909
87ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98912067
88OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98551540
89RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98309550
90POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.96741807
91CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96469970
92TCF4_22108803_ChIP-Seq_LS180_Human0.95528845
93BCAT_22108803_ChIP-Seq_LS180_Human0.94975748
94NANOG_18555785_Chip-Seq_ESCs_Mouse0.94962101
95CBP_20019798_ChIP-Seq_JUKART_Human0.94586699
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94586699
97WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93849339
98KDM2B_26808549_Chip-Seq_REH_Human0.93326132
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91955336
100CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.91462146

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color8.98671132
2MP0002653_abnormal_ependyma_morphology4.86678348
3MP0004885_abnormal_endolymph3.39275421
4MP0005171_absent_coat_pigmentation3.25425939
5MP0001485_abnormal_pinna_reflex2.57027769
6MP0002249_abnormal_larynx_morphology2.33996536
7MP0002638_abnormal_pupillary_reflex2.31699860
8MP0000778_abnormal_nervous_system2.27758060
9MP0004859_abnormal_synaptic_plasticity2.20349291
10MP0003880_abnormal_central_pattern2.18463086
11MP0005423_abnormal_somatic_nervous2.15056791
12MP0003635_abnormal_synaptic_transmissio2.08307988
13MP0002064_seizures2.01407265
14MP0009745_abnormal_behavioral_response1.96550737
15MP0004270_analgesia1.85589869
16MP0002572_abnormal_emotion/affect_behav1.85556142
17MP0002928_abnormal_bile_duct1.84106983
18MP0001486_abnormal_startle_reflex1.80373116
19MP0002063_abnormal_learning/memory/cond1.77398858
20MP0000026_abnormal_inner_ear1.76520490
21MP0001968_abnormal_touch/_nociception1.73467155
22MP0002272_abnormal_nervous_system1.73385830
23MP0004142_abnormal_muscle_tone1.72990443
24MP0002277_abnormal_respiratory_mucosa1.66665115
25MP0002736_abnormal_nociception_after1.62622432
26MP0002734_abnormal_mechanical_nocicepti1.60799373
27MP0001970_abnormal_pain_threshold1.52645009
28MP0001529_abnormal_vocalization1.52591421
29MP0002067_abnormal_sensory_capabilities1.50544427
30MP0004742_abnormal_vestibular_system1.49410971
31MP0000955_abnormal_spinal_cord1.49009053
32MP0002735_abnormal_chemical_nociception1.48391234
33MP0000631_abnormal_neuroendocrine_gland1.44655962
34MP0003283_abnormal_digestive_organ1.42840286
35MP0002282_abnormal_trachea_morphology1.41682005
36MP0001984_abnormal_olfaction1.40461048
37MP0009046_muscle_twitch1.36327556
38MP0005084_abnormal_gallbladder_morpholo1.35524059
39MP0005646_abnormal_pituitary_gland1.33161977
40MP0002733_abnormal_thermal_nociception1.32597283
41MP0005551_abnormal_eye_electrophysiolog1.30421505
42MP0005174_abnormal_tail_pigmentation1.27994640
43MP0002938_white_spotting1.27234150
44MP0001963_abnormal_hearing_physiology1.25298243
45MP0002557_abnormal_social/conspecific_i1.23247691
46MP0003634_abnormal_glial_cell1.21530028
47MP0009379_abnormal_foot_pigmentation1.19797129
48MP0000049_abnormal_middle_ear1.19345919
49MP0008569_lethality_at_weaning1.17958208
50MP0003632_abnormal_nervous_system1.16037855
51MP0004133_heterotaxia1.14348476
52MP0005187_abnormal_penis_morphology1.14117514
53MP0000762_abnormal_tongue_morphology1.13945173
54MP0002152_abnormal_brain_morphology1.11728188
55MP0002882_abnormal_neuron_morphology1.10246855
56MP0001502_abnormal_circadian_rhythm1.08896604
57MP0005253_abnormal_eye_physiology1.05165375
58MP0003633_abnormal_nervous_system1.04401704
59MP0002095_abnormal_skin_pigmentation1.03129075
60MP0003755_abnormal_palate_morphology1.01444863
61MP0006276_abnormal_autonomic_nervous1.00648120
62MP0006072_abnormal_retinal_apoptosis1.00642941
63MP0005195_abnormal_posterior_eye0.97412763
64MP0001270_distended_abdomen0.97224257
65MP0002752_abnormal_somatic_nervous0.95683322
66MP0000534_abnormal_ureter_morphology0.92597521
67MP0001286_abnormal_eye_development0.92478793
68MP0001299_abnormal_eye_distance/0.92086891
69MP0002751_abnormal_autonomic_nervous0.91550108
70MP0003631_nervous_system_phenotype0.91497323
71MP0005503_abnormal_tendon_morphology0.91420722
72MP0003690_abnormal_glial_cell0.89966325
73MP0000566_synostosis0.89918552
74MP0005377_hearing/vestibular/ear_phenot0.88370130
75MP0003878_abnormal_ear_physiology0.88370130
76MP0003011_delayed_dark_adaptation0.86039786
77MP0000647_abnormal_sebaceous_gland0.84242629
78MP0002066_abnormal_motor_capabilities/c0.83744129
79MP0005391_vision/eye_phenotype0.82405291
80MP0001440_abnormal_grooming_behavior0.82214952
81MP0003122_maternal_imprinting0.78839646
82MP0003861_abnormal_nervous_system0.78817568
83MP0004924_abnormal_behavior0.78716584
84MP0005386_behavior/neurological_phenoty0.78716584
85MP0001501_abnormal_sleep_pattern0.75771720
86MP0004185_abnormal_adipocyte_glucose0.72146957
87MP0000569_abnormal_digit_pigmentation0.71957090
88MP0002229_neurodegeneration0.71103077
89MP0009250_abnormal_appendicular_skeleto0.69204044
90MP0005595_abnormal_vascular_smooth0.68426791
91MP0002697_abnormal_eye_size0.68271627
92MP0001905_abnormal_dopamine_level0.66844707
93MP0000428_abnormal_craniofacial_morphol0.66562839
94MP0000920_abnormal_myelination0.66428104
95MP0002102_abnormal_ear_morphology0.65705451
96MP0002116_abnormal_craniofacial_bone0.65689802
97MP0004811_abnormal_neuron_physiology0.65576298
98MP0001177_atelectasis0.65336071
99MP0002184_abnormal_innervation0.65310508
100MP0004147_increased_porphyrin_level0.64508518

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)4.77977764
2Abnormality of the diencephalon (HP:0010662)4.34449568
3Focal motor seizures (HP:0011153)4.24861729
4Hemiparesis (HP:0001269)4.10835931
5Esophageal atresia (HP:0002032)4.09338914
6True hermaphroditism (HP:0010459)4.03922670
7Hemiplegia (HP:0002301)3.62802285
8Supernumerary bones of the axial skeleton (HP:0009144)3.53210582
9Hyperventilation (HP:0002883)3.52524490
10Abnormality of the 4th metacarpal (HP:0010012)3.46417550
11Progressive cerebellar ataxia (HP:0002073)3.46249681
12Morphological abnormality of the inner ear (HP:0011390)3.36537829
13Large for gestational age (HP:0001520)3.35232650
14Missing ribs (HP:0000921)3.29211534
15Gastrointestinal atresia (HP:0002589)3.28987295
16Supernumerary ribs (HP:0005815)3.18468199
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.12174094
18Short 4th metacarpal (HP:0010044)3.12174094
19Rib fusion (HP:0000902)3.09656013
20Bronchomalacia (HP:0002780)3.07959074
21Split foot (HP:0001839)2.93187556
22Vertebral hypoplasia (HP:0008417)2.90045578
23Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.90045578
24Fibular hypoplasia (HP:0003038)2.79040445
25Oligodactyly (hands) (HP:0001180)2.76407150
26Midline defect of the nose (HP:0004122)2.73970044
27Abnormal ciliary motility (HP:0012262)2.73430932
28Hemivertebrae (HP:0002937)2.71160949
29Anophthalmia (HP:0000528)2.71093366
30Molar tooth sign on MRI (HP:0002419)2.71010968
31Abnormality of midbrain morphology (HP:0002418)2.71010968
32Megalencephaly (HP:0001355)2.68217420
33Pancreatic fibrosis (HP:0100732)2.66086947
34Optic nerve hypoplasia (HP:0000609)2.61631208
35Abnormal respiratory motile cilium physiology (HP:0012261)2.60666807
36Neoplasm of the heart (HP:0100544)2.57560256
37Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.57378868
38Abnormality of cochlea (HP:0000375)2.55678022
39Pheochromocytoma (HP:0002666)2.52728663
40Maternal diabetes (HP:0009800)2.49213570
41Bone cyst (HP:0012062)2.48388969
42Aplasia/Hypoplasia of the fibula (HP:0006492)2.43905763
43Absent septum pellucidum (HP:0001331)2.43199947
44Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.42679494
45Oligodactyly (HP:0012165)2.42593143
46Neonatal short-limb short stature (HP:0008921)2.42494803
47Sclerocornea (HP:0000647)2.37944800
48Hamartoma (HP:0010566)2.37501991
49Pancreatic cysts (HP:0001737)2.34036591
50Nephronophthisis (HP:0000090)2.33811826
51Focal seizures (HP:0007359)2.29721510
52Abnormal respiratory motile cilium morphology (HP:0005938)2.29035762
53Abnormal respiratory epithelium morphology (HP:0012253)2.29035762
54Febrile seizures (HP:0002373)2.26282320
55Neuroendocrine neoplasm (HP:0100634)2.25890669
5611 pairs of ribs (HP:0000878)2.23668671
57Dynein arm defect of respiratory motile cilia (HP:0012255)2.23149967
58Absent/shortened dynein arms (HP:0200106)2.23149967
59Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.22242655
60Sex reversal (HP:0012245)2.22075973
61Abnormal sex determination (HP:0012244)2.22075973
62Atonic seizures (HP:0010819)2.14751156
63Ulnar claw (HP:0001178)2.14284056
64Aplasia/Hypoplasia of the sternum (HP:0006714)2.13171224
65Rhinitis (HP:0012384)2.11397301
66Action tremor (HP:0002345)2.09815638
67Bilateral microphthalmos (HP:0007633)2.08556997
68Benign neoplasm of the central nervous system (HP:0100835)2.08210294
69Coronal craniosynostosis (HP:0004440)2.07017596
70Aplasia involving bones of the upper limbs (HP:0009823)2.02280458
71Aplasia of the phalanges of the hand (HP:0009802)2.02280458
72Aplasia involving bones of the extremities (HP:0009825)2.02280458
73Medial flaring of the eyebrow (HP:0010747)2.00406740
74Neoplasm of the oral cavity (HP:0100649)1.96509746
75Abnormality of the renal medulla (HP:0100957)1.96069603
76Depressed nasal tip (HP:0000437)1.95870114
77Abnormality of the ischium (HP:0003174)1.93966565
78Myokymia (HP:0002411)1.92417950
79Specific learning disability (HP:0001328)1.92310764
80Gait imbalance (HP:0002141)1.91575144
81White forelock (HP:0002211)1.90490600
82Abnormal drinking behavior (HP:0030082)1.89182746
83Polydipsia (HP:0001959)1.89182746
84Median cleft lip (HP:0000161)1.88957494
85Patchy hypopigmentation of hair (HP:0011365)1.88364816
86Glioma (HP:0009733)1.87609254
87Spastic diplegia (HP:0001264)1.86637273
88Truncal ataxia (HP:0002078)1.86536310
89Meningioma (HP:0002858)1.86513101
90Congenital stationary night blindness (HP:0007642)1.85094470
91Type II lissencephaly (HP:0007260)1.84473887
92Retinal dysplasia (HP:0007973)1.83837617
93Generalized tonic-clonic seizures (HP:0002069)1.83596092
94Epileptic encephalopathy (HP:0200134)1.83299722
95Polyphagia (HP:0002591)1.83175603
96Abnormality of the septum pellucidum (HP:0007375)1.82518584
97Spastic tetraparesis (HP:0001285)1.80769204
98Occipital encephalocele (HP:0002085)1.78315649
99Aplasia/Hypoplasia of the tibia (HP:0005772)1.77222048
100Tracheomalacia (HP:0002779)1.77135237

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK7.62359608
2MAPK157.06658214
3TSSK64.92315158
4CASK3.96121424
5WEE13.56363947
6CAMK1D2.93828871
7CAMKK22.81592474
8NTRK22.61069704
9CAMK1G2.28060901
10NTRK32.04398075
11MARK12.01754165
12VRK11.70651271
13EPHB21.58485222
14EPHA41.55907536
15WNK41.49572265
16WNK31.45296853
17BMPR1B1.40057897
18TYRO31.34957849
19CAMKK11.33470480
20MAPK131.32083263
21CDK31.22164420
22PKN11.14301105
23STK391.09143975
24EPHA31.02208693
25PRKCG0.95524720
26PAK60.90488552
27MAP3K40.87572684
28MAPKAPK50.85185659
29DYRK20.81202984
30PINK10.75793011
31MKNK20.74031731
32PLK20.69808127
33MAP2K70.68959474
34SGK20.68325308
35ERBB20.67945900
36SGK2230.67239431
37SGK4940.67239431
38PRKD30.65982869
39PAK20.64251301
40SIK20.60230608
41TAOK30.59438894
42NTRK10.58619332
43TNIK0.58516508
44ADRBK20.55712056
45KSR10.53430384
46CSNK1G20.53196774
47CAMK10.52529478
48TGFBR10.52080267
49ERBB40.51437701
50EPHB10.48927367
51IRAK10.48442382
52CAMK2B0.47650728
53CSNK1G10.47582064
54CAMK40.47260985
55MAPKAPK30.46542857
56INSRR0.46214027
57ROCK10.45109165
58WNK10.43720533
59CAMK2A0.43447366
60MAP2K40.43245139
61GRK10.42276226
62PHKG10.41309536
63PHKG20.41309536
64CAMK2G0.41186699
65ROCK20.39714899
66PLK30.39436473
67UHMK10.38616477
68CAMK2D0.38181594
69DYRK1A0.36772106
70PRKCE0.35531767
71FGFR20.35069245
72GSK3A0.33432926
73MAP4K20.31800420
74MAPK100.30435343
75PRKCH0.30230349
76CDK50.28669591
77MAP2K20.28445730
78STK38L0.27562002
79YES10.26741808
80CSNK1G30.26577529
81PTK2B0.26409425
82SGK10.26007494
83PRKCZ0.25645420
84OXSR10.25266945
85PRKD10.24832010
86TAOK10.24379180
87ADRBK10.23585966
88DYRK30.22274622
89NEK60.22114451
90PRKD20.21293300
91PDGFRB0.20695539
92PRKACA0.20586645
93DAPK20.20402056
94MOS0.20240169
95FRK0.19590894
96PRKG10.18805882
97PBK0.18113339
98NLK0.17218816
99CSNK1A1L0.16066527
100MKNK10.16045284

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.38988889
2Nicotine addiction_Homo sapiens_hsa050333.04159964
3Cocaine addiction_Homo sapiens_hsa050302.35042525
4GABAergic synapse_Homo sapiens_hsa047272.26616643
5Steroid biosynthesis_Homo sapiens_hsa001002.18742630
6Nitrogen metabolism_Homo sapiens_hsa009102.12065321
7Butanoate metabolism_Homo sapiens_hsa006502.07648177
8Glutamatergic synapse_Homo sapiens_hsa047242.06117577
9Amphetamine addiction_Homo sapiens_hsa050311.93326444
10Estrogen signaling pathway_Homo sapiens_hsa049151.92885830
11Notch signaling pathway_Homo sapiens_hsa043301.90304125
12Basal cell carcinoma_Homo sapiens_hsa052171.90188291
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.87935364
14Taste transduction_Homo sapiens_hsa047421.86633286
15Morphine addiction_Homo sapiens_hsa050321.85541912
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.85376939
17PPAR signaling pathway_Homo sapiens_hsa033201.84697482
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.84436570
19Circadian entrainment_Homo sapiens_hsa047131.82317249
20Insulin secretion_Homo sapiens_hsa049111.80433242
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.68733797
22Axon guidance_Homo sapiens_hsa043601.64192502
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.62710984
24Gastric acid secretion_Homo sapiens_hsa049711.58092137
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56976381
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.48993520
27cAMP signaling pathway_Homo sapiens_hsa040241.48088376
28Phototransduction_Homo sapiens_hsa047441.47108262
29Hedgehog signaling pathway_Homo sapiens_hsa043401.44251310
30Dorso-ventral axis formation_Homo sapiens_hsa043201.42959239
31Cardiac muscle contraction_Homo sapiens_hsa042601.37996915
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.37385520
33Dopaminergic synapse_Homo sapiens_hsa047281.29812820
34Prion diseases_Homo sapiens_hsa050201.25647305
35Salivary secretion_Homo sapiens_hsa049701.19606899
36Hippo signaling pathway_Homo sapiens_hsa043901.19380379
37Bile secretion_Homo sapiens_hsa049761.18401427
38Cholinergic synapse_Homo sapiens_hsa047251.17047819
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15059915
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.13424571
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12510163
42Melanogenesis_Homo sapiens_hsa049161.09140151
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02320215
44Oxytocin signaling pathway_Homo sapiens_hsa049211.02183434
45Thyroid hormone synthesis_Homo sapiens_hsa049181.01863960
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.00005070
47Calcium signaling pathway_Homo sapiens_hsa040200.99106792
48Sulfur relay system_Homo sapiens_hsa041220.93899410
49Oxidative phosphorylation_Homo sapiens_hsa001900.93860529
50Olfactory transduction_Homo sapiens_hsa047400.93761142
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91825220
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90627116
53Parkinsons disease_Homo sapiens_hsa050120.89492725
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85850131
55Fanconi anemia pathway_Homo sapiens_hsa034600.84681412
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83640707
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83157759
58Propanoate metabolism_Homo sapiens_hsa006400.82267680
59Long-term depression_Homo sapiens_hsa047300.78897308
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.78736486
61Peroxisome_Homo sapiens_hsa041460.77429978
62Protein export_Homo sapiens_hsa030600.75625611
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75390451
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75164343
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74134538
66Gap junction_Homo sapiens_hsa045400.73992366
67beta-Alanine metabolism_Homo sapiens_hsa004100.73958630
68Huntingtons disease_Homo sapiens_hsa050160.71838490
69Renin secretion_Homo sapiens_hsa049240.71589726
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68158451
71Fatty acid metabolism_Homo sapiens_hsa012120.68054611
72Linoleic acid metabolism_Homo sapiens_hsa005910.66546151
73Tryptophan metabolism_Homo sapiens_hsa003800.63026665
74Fatty acid biosynthesis_Homo sapiens_hsa000610.62719878
75Serotonergic synapse_Homo sapiens_hsa047260.60281275
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59249411
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58702650
78Wnt signaling pathway_Homo sapiens_hsa043100.58542715
79TGF-beta signaling pathway_Homo sapiens_hsa043500.55766508
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54584561
81Glycerolipid metabolism_Homo sapiens_hsa005610.54154340
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54030982
83MAPK signaling pathway_Homo sapiens_hsa040100.53061007
84Alzheimers disease_Homo sapiens_hsa050100.51622535
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49662568
86Ovarian steroidogenesis_Homo sapiens_hsa049130.48361284
87Pancreatic secretion_Homo sapiens_hsa049720.44739018
88Choline metabolism in cancer_Homo sapiens_hsa052310.44561730
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43277503
90Alcoholism_Homo sapiens_hsa050340.42690647
91Chemical carcinogenesis_Homo sapiens_hsa052040.42499222
92ABC transporters_Homo sapiens_hsa020100.42001722
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40628280
94Histidine metabolism_Homo sapiens_hsa003400.40568557
95Ether lipid metabolism_Homo sapiens_hsa005650.37376651
96RNA polymerase_Homo sapiens_hsa030200.37208722
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36152403
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.35295866
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35132750
100Colorectal cancer_Homo sapiens_hsa052100.34948758

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