C1ORF35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)6.30436763
2viral transcription (GO:0019083)6.21848562
3translational termination (GO:0006415)5.98352401
4maturation of SSU-rRNA (GO:0030490)5.76087875
5ribosomal small subunit assembly (GO:0000028)5.36628428
6translational elongation (GO:0006414)5.14679973
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.13927923
8cotranslational protein targeting to membrane (GO:0006613)5.05855310
9protein targeting to ER (GO:0045047)5.00062981
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.79710405
11establishment of protein localization to endoplasmic reticulum (GO:0072599)4.75016540
12viral life cycle (GO:0019058)4.70326623
13protein localization to endoplasmic reticulum (GO:0070972)4.68200894
14cellular protein complex disassembly (GO:0043624)4.66065071
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.58483684
16regulation of mitochondrial translation (GO:0070129)4.56159271
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.55977602
18chaperone-mediated protein transport (GO:0072321)4.48339023
19protein complex biogenesis (GO:0070271)4.40245072
20ATP synthesis coupled proton transport (GO:0015986)4.33039630
21energy coupled proton transport, down electrochemical gradient (GO:0015985)4.33039630
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.32076770
23mitochondrial respiratory chain complex assembly (GO:0033108)4.29233527
24translational initiation (GO:0006413)4.27501583
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.24050841
26mitochondrial respiratory chain complex I assembly (GO:0032981)4.24050841
27NADH dehydrogenase complex assembly (GO:0010257)4.24050841
28protein complex disassembly (GO:0043241)4.18329397
29pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.09911714
30macromolecular complex disassembly (GO:0032984)3.96496387
31respiratory electron transport chain (GO:0022904)3.95056398
32electron transport chain (GO:0022900)3.89901327
33ribonucleoprotein complex biogenesis (GO:0022613)3.84825377
34DNA replication checkpoint (GO:0000076)3.81551182
35translation (GO:0006412)3.81426731
36telomere maintenance via semi-conservative replication (GO:0032201)3.76846797
37cellular component biogenesis (GO:0044085)3.75523882
38ribosomal large subunit biogenesis (GO:0042273)3.74589556
39DNA strand elongation involved in DNA replication (GO:0006271)3.72072244
40termination of RNA polymerase III transcription (GO:0006386)3.61862220
41transcription elongation from RNA polymerase III promoter (GO:0006385)3.61862220
42chromatin remodeling at centromere (GO:0031055)3.57682183
43DNA strand elongation (GO:0022616)3.53535609
44deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.52458167
45protein targeting to mitochondrion (GO:0006626)3.47964462
46nuclear-transcribed mRNA catabolic process (GO:0000956)3.47562515
47pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.44511969
48pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.41122095
49establishment of protein localization to mitochondrion (GO:0072655)3.38811936
50rRNA processing (GO:0006364)3.37058401
51RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.36953987
52tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.36953987
53DNA damage response, detection of DNA damage (GO:0042769)3.36657276
54protein-cofactor linkage (GO:0018065)3.35097952
55pseudouridine synthesis (GO:0001522)3.33998059
56protein targeting to membrane (GO:0006612)3.33080129
57pyrimidine nucleotide catabolic process (GO:0006244)3.32207847
58mRNA catabolic process (GO:0006402)3.31580911
59nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.31341455
60rRNA metabolic process (GO:0016072)3.26376389
61protein localization to mitochondrion (GO:0070585)3.24755434
62CTP biosynthetic process (GO:0006241)3.24064093
63CTP metabolic process (GO:0046036)3.24064093
64kinetochore assembly (GO:0051382)3.23178171
65spliceosomal snRNP assembly (GO:0000387)3.23113441
66CENP-A containing nucleosome assembly (GO:0034080)3.21415886
67pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.20972722
68exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.20824643
69cytochrome complex assembly (GO:0017004)3.19705279
70kinetochore organization (GO:0051383)3.19274510
71pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.19096842
72replication fork processing (GO:0031297)3.18945088
73protein neddylation (GO:0045116)3.17446889
74telomere maintenance via recombination (GO:0000722)3.14466170
75heterochromatin organization (GO:0070828)3.11385968
76base-excision repair, AP site formation (GO:0006285)3.11227132
77GTP biosynthetic process (GO:0006183)3.10752135
78RNA catabolic process (GO:0006401)3.10501451
79DNA replication initiation (GO:0006270)3.06285774
80peptidyl-histidine modification (GO:0018202)3.05538745
81respiratory chain complex IV assembly (GO:0008535)3.05405084
82UTP biosynthetic process (GO:0006228)3.04898400
83pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.00313549
84ribosome biogenesis (GO:0042254)2.99245716
85behavioral response to nicotine (GO:0035095)2.96778509
86pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.94749811
87regulation of nuclear cell cycle DNA replication (GO:0033262)2.94556670
88pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.94184762
89proteasome assembly (GO:0043248)2.93339998
90nucleotide-excision repair, DNA gap filling (GO:0006297)2.91785992
91protein K6-linked ubiquitination (GO:0085020)2.91248571
92rRNA modification (GO:0000154)2.90166589
93mitotic recombination (GO:0006312)2.89882035
94transcription-coupled nucleotide-excision repair (GO:0006283)2.89495472
95negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.87853904
96intracellular protein transmembrane import (GO:0044743)2.85381648
97tRNA processing (GO:0008033)2.80864951
98pyrimidine nucleotide biosynthetic process (GO:0006221)2.79785200
99guanosine-containing compound biosynthetic process (GO:1901070)2.79583409
100DNA deamination (GO:0045006)2.78342133

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.76108684
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.81664323
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.66962041
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.60951207
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.53072718
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.52061439
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.24298720
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.23571665
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.22063389
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.91853829
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.89825247
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85799143
13XRN2_22483619_ChIP-Seq_HELA_Human2.79247414
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.78891191
15THAP11_20581084_ChIP-Seq_MESCs_Mouse2.63135004
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.61872593
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.58701946
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.50748746
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.48251032
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.46887385
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44823494
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.37411919
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.29853350
24TTF2_22483619_ChIP-Seq_HELA_Human2.29791463
25* GABP_19822575_ChIP-Seq_HepG2_Human2.27689677
26MYC_19079543_ChIP-ChIP_MESCs_Mouse2.21427275
27* VDR_23849224_ChIP-Seq_CD4+_Human2.07775057
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.05091750
29* DCP1A_22483619_ChIP-Seq_HELA_Human2.02396545
30YY1_21170310_ChIP-Seq_MESCs_Mouse2.01092782
31FOXM1_23109430_ChIP-Seq_U2OS_Human2.00403319
32FOXP3_21729870_ChIP-Seq_TREG_Human1.99203805
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85887557
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.84695798
35CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.83984185
36* KDM5A_27292631_Chip-Seq_BREAST_Human1.76042689
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74821646
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.74257718
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.68532580
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.67649335
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65156385
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.64992655
43MYC_18940864_ChIP-ChIP_HL60_Human1.59452590
44CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.58570826
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52441971
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.51886981
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40716528
48SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.38476708
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37868980
50ELK1_19687146_ChIP-ChIP_HELA_Human1.34836149
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34732918
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.33395978
53* FOXP1_21924763_ChIP-Seq_HESCs_Human1.33352035
54ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31952058
55KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.31739958
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30983533
57BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.30900238
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30453153
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29988337
60CTCF_18555785_ChIP-Seq_MESCs_Mouse1.29139596
61MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29131310
62* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.27332330
63CIITA_25753668_ChIP-Seq_RAJI_Human1.24359073
64CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.23408777
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.23405916
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21267222
67VDR_21846776_ChIP-Seq_THP-1_Human1.20534589
68NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19355132
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19150212
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17193365
71SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16406932
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14345819
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12725676
74SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12482852
75P68_20966046_ChIP-Seq_HELA_Human1.12119097
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09416103
77NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07828300
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05936696
79HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05467199
80RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.01965743
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00109891
82PHF8_20622854_ChIP-Seq_HELA_Human0.99703988
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99061152
84ELF1_20517297_ChIP-Seq_JURKAT_Human0.99033548
85* BCL6_27268052_Chip-Seq_Bcells_Human0.95983094
86ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95453230
87YY1_22570637_ChIP-Seq_MALME-3M_Human0.94525943
88* E2F1_20622854_ChIP-Seq_HELA_Human0.94168085
89NOTCH1_21737748_ChIP-Seq_TLL_Human0.91798975
90CTCF_26484167_Chip-Seq_Bcells_Mouse0.89550908
91SOX2_16153702_ChIP-ChIP_HESCs_Human0.83992729
92ERA_21632823_ChIP-Seq_H3396_Human0.82712616
93* IRF1_19129219_ChIP-ChIP_H3396_Human0.81275616
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.80741229
95CTCF_20526341_ChIP-Seq_ESCs_Human0.79470479
96SA1_27219007_Chip-Seq_ERYTHROID_Human0.78024093
97ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77826102
98RARA_24833708_ChIP-Seq_LIVER_Mouse0.76674902
99CBX2_27304074_Chip-Seq_ESCs_Mouse0.76601962
100PADI4_21655091_ChIP-ChIP_MCF-7_Human0.76289238

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.37882693
2MP0009379_abnormal_foot_pigmentation3.89676861
3MP0003693_abnormal_embryo_hatching3.16782764
4MP0010094_abnormal_chromosome_stability2.89727436
5MP0010030_abnormal_orbit_morphology2.88009128
6MP0008058_abnormal_DNA_repair2.70561099
7MP0003111_abnormal_nucleus_morphology2.64981603
8MP0000566_synostosis2.55948154
9MP0003136_yellow_coat_color2.39415026
10MP0002653_abnormal_ependyma_morphology2.31230403
11MP0003077_abnormal_cell_cycle2.12033636
12MP0008789_abnormal_olfactory_epithelium2.07787272
13MP0003123_paternal_imprinting2.04319906
14MP0002938_white_spotting1.97520060
15MP0003878_abnormal_ear_physiology1.95278311
16MP0005377_hearing/vestibular/ear_phenot1.95278311
17MP0000049_abnormal_middle_ear1.95179087
18MP0003786_premature_aging1.86840482
19MP0002249_abnormal_larynx_morphology1.82999820
20MP0001293_anophthalmia1.79046161
21MP0001346_abnormal_lacrimal_gland1.75553256
22MP0008932_abnormal_embryonic_tissue1.75461977
23MP0002234_abnormal_pharynx_morphology1.75276063
24MP0008995_early_reproductive_senescence1.75130958
25MP0005499_abnormal_olfactory_system1.74787652
26MP0005394_taste/olfaction_phenotype1.74787652
27MP0004957_abnormal_blastocyst_morpholog1.67222689
28MP0008877_abnormal_DNA_methylation1.65414941
29MP0003718_maternal_effect1.62959519
30MP0002160_abnormal_reproductive_system1.47991492
31MP0006036_abnormal_mitochondrial_physio1.47718606
32MP0002638_abnormal_pupillary_reflex1.47223161
33MP0003121_genomic_imprinting1.46437794
34MP0002210_abnormal_sex_determination1.46249696
35MP0000631_abnormal_neuroendocrine_gland1.43644758
36MP0003806_abnormal_nucleotide_metabolis1.42479669
37MP0003186_abnormal_redox_activity1.37836436
38MP0002102_abnormal_ear_morphology1.35719115
39MP0006035_abnormal_mitochondrial_morpho1.34789433
40MP0003938_abnormal_ear_development1.33280626
41MP0001529_abnormal_vocalization1.32612288
42MP0008057_abnormal_DNA_replication1.28584983
43MP0001905_abnormal_dopamine_level1.24217753
44MP0002277_abnormal_respiratory_mucosa1.23812637
45MP0002736_abnormal_nociception_after1.23641323
46MP0004133_heterotaxia1.20165857
47MP0006072_abnormal_retinal_apoptosis1.18888578
48MP0003011_delayed_dark_adaptation1.18605979
49MP0008007_abnormal_cellular_replicative1.16834823
50MP0001188_hyperpigmentation1.15819032
51MP0003937_abnormal_limbs/digits/tail_de1.14118397
52MP0001986_abnormal_taste_sensitivity1.13394342
53MP0001929_abnormal_gametogenesis1.09190212
54MP0001485_abnormal_pinna_reflex1.09145635
55MP0002163_abnormal_gland_morphology1.08863445
56MP0001968_abnormal_touch/_nociception1.08504788
57MP0001145_abnormal_male_reproductive1.08377949
58MP0004142_abnormal_muscle_tone1.07823158
59MP0003880_abnormal_central_pattern1.04643501
60MP0005389_reproductive_system_phenotype1.04267758
61MP0003698_abnormal_male_reproductive1.03819381
62MP0000653_abnormal_sex_gland1.01699349
63MP0003787_abnormal_imprinting1.00985113
64MP0003315_abnormal_perineum_morphology0.99621761
65MP0000026_abnormal_inner_ear0.99589700
66MP0001286_abnormal_eye_development0.98983867
67MP0000372_irregular_coat_pigmentation0.97816676
68MP0005646_abnormal_pituitary_gland0.95708946
69MP0009697_abnormal_copulation0.93713705
70MP0001919_abnormal_reproductive_system0.93389287
71MP0001764_abnormal_homeostasis0.89985842
72MP0002822_catalepsy0.89966512
73MP0006276_abnormal_autonomic_nervous0.89304110
74MP0000678_abnormal_parathyroid_gland0.87575690
75MP0002697_abnormal_eye_size0.86970426
76MP0003755_abnormal_palate_morphology0.86284520
77MP0005423_abnormal_somatic_nervous0.84882178
78MP0000778_abnormal_nervous_system0.84612390
79MP0003942_abnormal_urinary_system0.84453297
80MP0005391_vision/eye_phenotype0.83430442
81MP0002233_abnormal_nose_morphology0.82696199
82MP0003122_maternal_imprinting0.82554728
83MP0005551_abnormal_eye_electrophysiolog0.81463583
84MP0004742_abnormal_vestibular_system0.81226828
85MP0005410_abnormal_fertilization0.80650215
86MP0002282_abnormal_trachea_morphology0.80554419
87MP0000350_abnormal_cell_proliferation0.80484913
88MP0003861_abnormal_nervous_system0.80331286
89MP0000358_abnormal_cell_content/0.78720362
90MP0002111_abnormal_tail_morphology0.78577648
91MP0002752_abnormal_somatic_nervous0.77938537
92MP0002085_abnormal_embryonic_tissue0.76877600
93MP0002095_abnormal_skin_pigmentation0.76066112
94MP0005195_abnormal_posterior_eye0.75498209
95MP0002092_abnormal_eye_morphology0.73491521
96MP0009046_muscle_twitch0.73065155
97MP0003137_abnormal_impulse_conducting0.72348551
98MP0005253_abnormal_eye_physiology0.72041731
99MP0000313_abnormal_cell_death0.71970366
100MP0009250_abnormal_appendicular_skeleto0.70256322

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.59182634
2Reticulocytopenia (HP:0001896)4.38180612
3Abnormal mitochondria in muscle tissue (HP:0008316)4.34059550
4Abnormality of cells of the erythroid lineage (HP:0012130)4.32309630
5Mitochondrial inheritance (HP:0001427)4.29246664
6Abnormal number of erythroid precursors (HP:0012131)4.25405191
7Acute encephalopathy (HP:0006846)4.06080619
8Increased CSF lactate (HP:0002490)3.73334713
9Hepatocellular necrosis (HP:0001404)3.72359581
10Rib fusion (HP:0000902)3.62143468
11Progressive macrocephaly (HP:0004481)3.61712819
12Macrocytic anemia (HP:0001972)3.38756771
13Lipid accumulation in hepatocytes (HP:0006561)3.38202904
14Increased hepatocellular lipid droplets (HP:0006565)3.35651761
15Hepatic necrosis (HP:0002605)3.33018482
16Renal Fanconi syndrome (HP:0001994)2.99316299
17Aplasia/Hypoplasia of the sacrum (HP:0008517)2.98478389
18Chromosomal breakage induced by crosslinking agents (HP:0003221)2.97306949
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.97229137
20Pallor (HP:0000980)2.87488087
21Cerebral edema (HP:0002181)2.84171988
22Birth length less than 3rd percentile (HP:0003561)2.81643961
23Increased intramyocellular lipid droplets (HP:0012240)2.78446944
24Chromsome breakage (HP:0040012)2.73964445
25Decreased activity of mitochondrial respiratory chain (HP:0008972)2.69845624
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.69845624
273-Methylglutaconic aciduria (HP:0003535)2.66750712
28Absent thumb (HP:0009777)2.60891925
29Increased muscle lipid content (HP:0009058)2.59816849
30Pancreatic fibrosis (HP:0100732)2.55534271
31Lactic acidosis (HP:0003128)2.53972677
32Microvesicular hepatic steatosis (HP:0001414)2.53692450
33Increased serum lactate (HP:0002151)2.52763272
34Patellar aplasia (HP:0006443)2.46433245
35Aplasia/Hypoplasia of the patella (HP:0006498)2.43940118
36Abnormality of midbrain morphology (HP:0002418)2.41232062
37Molar tooth sign on MRI (HP:0002419)2.41232062
38Exercise intolerance (HP:0003546)2.38982313
39Testicular atrophy (HP:0000029)2.37609094
40Meckel diverticulum (HP:0002245)2.37247811
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.36800068
42Abnormality of the ileum (HP:0001549)2.36302526
43Abnormal number of incisors (HP:0011064)2.34610082
44Microretrognathia (HP:0000308)2.30376689
45Hyperthyroidism (HP:0000836)2.28569460
46Triphalangeal thumb (HP:0001199)2.28441276
47Sclerocornea (HP:0000647)2.22579207
48Respiratory failure (HP:0002878)2.21971731
49Pancreatic cysts (HP:0001737)2.19774087
50Optic disc pallor (HP:0000543)2.18660058
51Septo-optic dysplasia (HP:0100842)2.14392882
52Horseshoe kidney (HP:0000085)2.13803007
53Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.13090332
54Respiratory difficulties (HP:0002880)2.12829496
55True hermaphroditism (HP:0010459)2.12356516
56Cerebral hypomyelination (HP:0006808)2.10109269
57Concave nail (HP:0001598)2.08485919
58Pendular nystagmus (HP:0012043)2.08261777
59Abnormality of the preputium (HP:0100587)2.05758718
60Progressive microcephaly (HP:0000253)2.04574910
61Exertional dyspnea (HP:0002875)2.01417465
62Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.01210480
63Nephronophthisis (HP:0000090)1.99647044
64Cleft eyelid (HP:0000625)1.97443068
65Leukodystrophy (HP:0002415)1.96151447
66Pancytopenia (HP:0001876)1.95529894
67Aplastic anemia (HP:0001915)1.91988813
68Ectopic kidney (HP:0000086)1.90647370
69Flat capital femoral epiphysis (HP:0003370)1.86348079
70Hyperglycinemia (HP:0002154)1.85512408
71Short thumb (HP:0009778)1.85385186
72Lethargy (HP:0001254)1.84855592
73Abnormal rod and cone electroretinograms (HP:0008323)1.82642463
74Breast hypoplasia (HP:0003187)1.81978736
75Truncus arteriosus (HP:0001660)1.81342592
76Abnormality of the carotid arteries (HP:0005344)1.79480462
77Holoprosencephaly (HP:0001360)1.77047846
78Aplasia/Hypoplasia of the earlobes (HP:0009906)1.76966389
79Congenital stationary night blindness (HP:0007642)1.76147488
80Emotional lability (HP:0000712)1.74633029
81Hypoplasia of the radius (HP:0002984)1.74495328
82Preaxial hand polydactyly (HP:0001177)1.74458103
83Occipital encephalocele (HP:0002085)1.74441691
84Opisthotonus (HP:0002179)1.74095312
85Esophageal atresia (HP:0002032)1.72337303
86Methylmalonic aciduria (HP:0012120)1.72024349
87Abnormality of renal resorption (HP:0011038)1.71336055
88Hyperglycinuria (HP:0003108)1.69869735
89Rectal fistula (HP:0100590)1.69781409
90Rectovaginal fistula (HP:0000143)1.69781409
91Hypoplastic pelvis (HP:0008839)1.69402121
92Anencephaly (HP:0002323)1.67850872
93Absent forearm bone (HP:0003953)1.67692724
94Aplasia involving forearm bones (HP:0009822)1.67692724
95Anophthalmia (HP:0000528)1.66964305
96Abnormality of DNA repair (HP:0003254)1.66518186
97Colon cancer (HP:0003003)1.66000945
98Optic nerve coloboma (HP:0000588)1.65402557
99Aganglionic megacolon (HP:0002251)1.64643618
100CNS demyelination (HP:0007305)1.64571658

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.34279975
2CDC73.96368014
3BUB13.42003204
4BCKDK3.06434848
5NME23.01110869
6STK162.88421356
7TLK12.85584014
8ZAK2.45311203
9PLK42.37872267
10TRIM282.36656008
11NUAK12.30783262
12NME12.29976749
13PNCK2.26892365
14WEE12.20315337
15VRK12.09438822
16DYRK21.91995383
17SRPK11.75720132
18MAPK151.72656777
19AURKA1.70024134
20WNK41.67489976
21CHEK21.65332911
22PLK11.59608969
23ATR1.55769226
24MAP3K111.50223514
25PASK1.39950955
26TESK21.35830073
27CSNK1G31.30427204
28AURKB1.28947090
29KDR1.27285031
30NEK21.25593998
31DYRK31.23470070
32BMPR1B1.20880044
33PDK21.19535941
34TTK1.17538211
35BRSK11.16838294
36CDK81.14659484
37TAF11.12826145
38CCNB11.07698408
39CSNK1G21.04698384
40MAP4K21.00376397
41CSNK1G10.98417255
42PLK30.98218613
43EPHB20.97388447
44MAP2K70.95973755
45WNK30.95249530
46LRRK20.94099915
47CDK70.93384579
48IRAK20.89297968
49RPS6KA50.88605958
50PBK0.87152571
51ADRBK20.82984603
52CHEK10.82861847
53PIM20.81647088
54ABL20.79273242
55BRSK20.78476090
56CSNK2A10.77499674
57CSNK2A20.76345180
58CDK190.72572419
59GRK10.72342844
60RPS6KB20.71443702
61PRKCI0.69471968
62ATM0.67959768
63CSNK1E0.65648831
64CDK20.64723440
65CDK40.64114536
66ILK0.60813500
67MAP3K100.58698482
68NEK10.56697755
69CDK10.56325499
70CSNK1A10.54550490
71CSNK1A1L0.53611698
72EPHA40.49478856
73DYRK1B0.48946945
74PRKCG0.46260090
75IKBKB0.45536259
76PINK10.44491657
77RPS6KA40.44178827
78DAPK30.44032351
79MAPK130.40345618
80MAP2K40.37735205
81LIMK10.37012498
82INSRR0.36655139
83PRKDC0.35913596
84BRAF0.34998180
85STK40.34888542
86CDK30.34358795
87STK390.30909385
88SIK20.30719864
89AKT10.30280691
90GRK60.29665110
91SMG10.29479181
92CDK11A0.29378957
93MUSK0.29258945
94MAPKAPK30.28664835
95PRKD30.28435805
96RPS6KA60.28177364
97MAP2K20.27634760
98PAK10.27244940
99PRKD20.27214718
100PIM10.27110223

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.47293332
2DNA replication_Homo sapiens_hsa030303.98513100
3Oxidative phosphorylation_Homo sapiens_hsa001903.85950683
4Parkinsons disease_Homo sapiens_hsa050123.41031749
5RNA polymerase_Homo sapiens_hsa030203.10306664
6Homologous recombination_Homo sapiens_hsa034403.07043209
7Base excision repair_Homo sapiens_hsa034102.94953612
8Mismatch repair_Homo sapiens_hsa034302.89520282
9Sulfur relay system_Homo sapiens_hsa041222.73744055
10Fanconi anemia pathway_Homo sapiens_hsa034602.68360392
11Proteasome_Homo sapiens_hsa030502.60217013
12Huntingtons disease_Homo sapiens_hsa050162.55430597
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.39461021
14Pyrimidine metabolism_Homo sapiens_hsa002402.37057279
15Spliceosome_Homo sapiens_hsa030402.35279733
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.15587037
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.10445173
18Nucleotide excision repair_Homo sapiens_hsa034202.06577191
19Alzheimers disease_Homo sapiens_hsa050102.06520744
20Protein export_Homo sapiens_hsa030601.68287984
21One carbon pool by folate_Homo sapiens_hsa006701.63413357
22RNA transport_Homo sapiens_hsa030131.61627410
23Basal transcription factors_Homo sapiens_hsa030221.56807749
24Cardiac muscle contraction_Homo sapiens_hsa042601.54840406
25RNA degradation_Homo sapiens_hsa030181.47855536
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.40693755
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34989674
28Purine metabolism_Homo sapiens_hsa002301.33512005
29Cell cycle_Homo sapiens_hsa041101.27984626
30Folate biosynthesis_Homo sapiens_hsa007901.22262576
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18978246
32Selenocompound metabolism_Homo sapiens_hsa004501.11881912
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03358548
34Basal cell carcinoma_Homo sapiens_hsa052171.03280388
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98555787
36Non-homologous end-joining_Homo sapiens_hsa034500.98209086
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95232211
38Fatty acid elongation_Homo sapiens_hsa000620.89432810
39Cysteine and methionine metabolism_Homo sapiens_hsa002700.87482824
40Hedgehog signaling pathway_Homo sapiens_hsa043400.85224534
41Metabolic pathways_Homo sapiens_hsa011000.82351877
42Pyruvate metabolism_Homo sapiens_hsa006200.78718182
43Glutathione metabolism_Homo sapiens_hsa004800.76234538
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76176367
45Drug metabolism - other enzymes_Homo sapiens_hsa009830.69638460
46mRNA surveillance pathway_Homo sapiens_hsa030150.65444235
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64452684
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.61670744
49Biosynthesis of amino acids_Homo sapiens_hsa012300.59887226
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59623642
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56482153
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55185250
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.52169427
54Peroxisome_Homo sapiens_hsa041460.51327200
55Steroid biosynthesis_Homo sapiens_hsa001000.47977163
56Butanoate metabolism_Homo sapiens_hsa006500.46609106
57Collecting duct acid secretion_Homo sapiens_hsa049660.45420020
58Phototransduction_Homo sapiens_hsa047440.45275017
59p53 signaling pathway_Homo sapiens_hsa041150.42820620
60Nitrogen metabolism_Homo sapiens_hsa009100.42581249
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42310274
62Carbon metabolism_Homo sapiens_hsa012000.42223407
63Propanoate metabolism_Homo sapiens_hsa006400.41235856
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38269124
65Tyrosine metabolism_Homo sapiens_hsa003500.37399550
66Fructose and mannose metabolism_Homo sapiens_hsa000510.37101798
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36769859
68Arginine and proline metabolism_Homo sapiens_hsa003300.35605191
69Epstein-Barr virus infection_Homo sapiens_hsa051690.35082744
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34495376
71Systemic lupus erythematosus_Homo sapiens_hsa053220.33682980
72Alcoholism_Homo sapiens_hsa050340.32892264
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32809667
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31841851
75Tryptophan metabolism_Homo sapiens_hsa003800.30898645
76Phenylalanine metabolism_Homo sapiens_hsa003600.30240165
77Hippo signaling pathway_Homo sapiens_hsa043900.29958254
78Regulation of autophagy_Homo sapiens_hsa041400.29811690
79Wnt signaling pathway_Homo sapiens_hsa043100.26807959
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26446114
81N-Glycan biosynthesis_Homo sapiens_hsa005100.26239642
82Oocyte meiosis_Homo sapiens_hsa041140.25444938
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25216928
84Nicotine addiction_Homo sapiens_hsa050330.24901022
85Linoleic acid metabolism_Homo sapiens_hsa005910.23960463
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23004056
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22957027
88Sulfur metabolism_Homo sapiens_hsa009200.22818899
89Notch signaling pathway_Homo sapiens_hsa043300.22375541
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21591472
91Primary immunodeficiency_Homo sapiens_hsa053400.21572684
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20478730
93Chemical carcinogenesis_Homo sapiens_hsa052040.19303577
94Olfactory transduction_Homo sapiens_hsa047400.19269763
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18894112
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.15484165
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.14703685
98beta-Alanine metabolism_Homo sapiens_hsa004100.14067269
99Vitamin digestion and absorption_Homo sapiens_hsa049770.13049839
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.11854349

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