C1ORF27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1centriole replication (GO:0007099)4.14210264
2proteasome assembly (GO:0043248)3.90722165
3neuron cell-cell adhesion (GO:0007158)3.87494984
4replication fork processing (GO:0031297)3.84373476
5peptidyl-histidine modification (GO:0018202)3.73879489
6ER overload response (GO:0006983)3.68587108
7regulation of meiosis I (GO:0060631)3.61231048
8regulation of centriole replication (GO:0046599)3.57030232
9atrial cardiac muscle cell action potential (GO:0086014)3.55680498
10mitotic sister chromatid cohesion (GO:0007064)3.45842659
11lactate metabolic process (GO:0006089)3.41305340
12single strand break repair (GO:0000012)3.35111811
13negative regulation of DNA-dependent DNA replication (GO:2000104)3.32428837
14prenylation (GO:0097354)3.30303019
15protein prenylation (GO:0018342)3.30303019
16L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.29044527
17signal peptide processing (GO:0006465)3.26430837
18detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.22855123
19postreplication repair (GO:0006301)3.22365360
20kinetochore organization (GO:0051383)3.20521455
21kinetochore assembly (GO:0051382)3.17810093
22maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.17728631
23respiratory chain complex IV assembly (GO:0008535)3.15056890
24regulation of translation in response to stress (GO:0043555)3.14710933
25chromatin remodeling at centromere (GO:0031055)3.14143267
26DNA double-strand break processing (GO:0000729)3.12619813
27platelet dense granule organization (GO:0060155)3.08885549
28CENP-A containing nucleosome assembly (GO:0034080)3.07239570
29amino-acid betaine metabolic process (GO:0006577)3.06078184
30positive regulation of macrophage activation (GO:0043032)3.01292586
31L-methionine salvage (GO:0071267)2.96339065
32L-methionine biosynthetic process (GO:0071265)2.96339065
33amino acid salvage (GO:0043102)2.96339065
34regulation of hexokinase activity (GO:1903299)2.95376514
35regulation of glucokinase activity (GO:0033131)2.95376514
36neural tube formation (GO:0001841)2.92438713
37regulation of nuclear cell cycle DNA replication (GO:0033262)2.91471417
38keratinocyte development (GO:0003334)2.89147083
39regulation of DNA endoreduplication (GO:0032875)2.88783756
40adenosine metabolic process (GO:0046085)2.87660217
41mitochondrial RNA metabolic process (GO:0000959)2.85145246
42water-soluble vitamin biosynthetic process (GO:0042364)2.83035883
43histone mRNA metabolic process (GO:0008334)2.81317971
44toxin transport (GO:1901998)2.80428272
45regulation of mitotic spindle checkpoint (GO:1903504)2.79309813
46regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.79309813
47RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.78933425
48intraciliary transport (GO:0042073)2.75078105
49microtubule nucleation (GO:0007020)2.73800190
50centriole assembly (GO:0098534)2.73384971
51mitochondrial respiratory chain complex I assembly (GO:0032981)2.71795920
52NADH dehydrogenase complex assembly (GO:0010257)2.71795920
53mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.71795920
54protein complex biogenesis (GO:0070271)2.71115381
55cell wall macromolecule catabolic process (GO:0016998)2.67339986
56histone exchange (GO:0043486)2.67046215
57mitochondrial respiratory chain complex assembly (GO:0033108)2.66602063
58methionine biosynthetic process (GO:0009086)2.66430301
59positive regulation of glycolytic process (GO:0045821)2.64455649
60cytochrome complex assembly (GO:0017004)2.64239848
61viral mRNA export from host cell nucleus (GO:0046784)2.61542918
62histone mRNA catabolic process (GO:0071044)2.59324697
63genitalia morphogenesis (GO:0035112)2.57187860
64aldehyde catabolic process (GO:0046185)2.54288596
65double-strand break repair via homologous recombination (GO:0000724)2.54212328
66recombinational repair (GO:0000725)2.52874754
67DNA replication checkpoint (GO:0000076)2.52100491
68mannosylation (GO:0097502)2.50992788
69regulation of centrosome duplication (GO:0010824)2.49899766
70cullin deneddylation (GO:0010388)2.46446003
71nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.45380116
72exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.45064836
73positive regulation of glycoprotein biosynthetic process (GO:0010560)2.42964903
74presynaptic membrane assembly (GO:0097105)2.42674679
75centrosome organization (GO:0051297)2.41760253
76C4-dicarboxylate transport (GO:0015740)2.41559136
77regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.41202897
78histone H2A ubiquitination (GO:0033522)2.41165488
79L-fucose catabolic process (GO:0042355)2.39995112
80fucose catabolic process (GO:0019317)2.39995112
81L-fucose metabolic process (GO:0042354)2.39995112
82DNA demethylation (GO:0080111)2.38203908
83base-excision repair, AP site formation (GO:0006285)2.37338423
84negative regulation of cAMP-mediated signaling (GO:0043951)2.37291577
85pseudouridine synthesis (GO:0001522)2.37152270
86S-adenosylmethionine metabolic process (GO:0046500)2.36418932
87cellular respiration (GO:0045333)2.36050200
88microtubule organizing center organization (GO:0031023)2.35289768
89tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.34516317
90RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.34516317
91zinc ion transport (GO:0006829)2.33486525
92synapsis (GO:0007129)2.33227433
93methionine metabolic process (GO:0006555)2.33146908
94positive regulation of mitotic sister chromatid separation (GO:1901970)2.33144156
95positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.33144156
96positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.33144156
97regulation of translation, ncRNA-mediated (GO:0045974)2.32528350
98negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.32528350
99negative regulation of translation, ncRNA-mediated (GO:0040033)2.32528350
100regulation of centrosome cycle (GO:0046605)2.31914984

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.36330090
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.01079007
3POU3F2_20337985_ChIP-ChIP_501MEL_Human2.78831132
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.72092607
5VDR_22108803_ChIP-Seq_LS180_Human2.66952758
6ELK1_19687146_ChIP-ChIP_HELA_Human2.39770629
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.30873883
8ZNF274_21170338_ChIP-Seq_K562_Hela2.28829286
9GBX2_23144817_ChIP-Seq_PC3_Human2.26619374
10EWS_26573619_Chip-Seq_HEK293_Human2.17070235
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17016766
12FUS_26573619_Chip-Seq_HEK293_Human2.15250763
13* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10808721
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.06282878
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.02809655
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.01463045
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99567493
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96771662
19TAF15_26573619_Chip-Seq_HEK293_Human1.94895104
20IGF1R_20145208_ChIP-Seq_DFB_Human1.94740856
21P300_19829295_ChIP-Seq_ESCs_Human1.85251300
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.83803401
23* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.78074110
24EZH2_27294783_Chip-Seq_NPCs_Mouse1.76676462
25SUZ12_27294783_Chip-Seq_NPCs_Mouse1.75500663
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72962443
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.72834952
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70735170
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.69696767
30ER_23166858_ChIP-Seq_MCF-7_Human1.69496259
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.66915941
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56894404
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56794776
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55989859
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54976204
36VDR_23849224_ChIP-Seq_CD4+_Human1.54410426
37MYC_18940864_ChIP-ChIP_HL60_Human1.53202454
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51778984
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47996495
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47261990
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44694511
42NANOG_18555785_Chip-Seq_ESCs_Mouse1.44071488
43SMAD4_21799915_ChIP-Seq_A2780_Human1.44008957
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.43475974
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42467600
46CBP_20019798_ChIP-Seq_JUKART_Human1.38961653
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38961653
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38574935
49RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.37528472
50BCAT_22108803_ChIP-Seq_LS180_Human1.37255717
51RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36931482
52EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36310856
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36014706
54CRX_20693478_ChIP-Seq_RETINA_Mouse1.35940588
55CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.33745359
56P53_22387025_ChIP-Seq_ESCs_Mouse1.32452506
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30979096
58CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30870465
59STAT3_23295773_ChIP-Seq_U87_Human1.30840020
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30524351
61P300_18555785_Chip-Seq_ESCs_Mouse1.28006284
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27633768
63E2F1_18555785_Chip-Seq_ESCs_Mouse1.27413470
64FOXP3_21729870_ChIP-Seq_TREG_Human1.27314610
65E2F7_22180533_ChIP-Seq_HELA_Human1.27157902
66CMYC_18555785_Chip-Seq_ESCs_Mouse1.25677972
67AR_25329375_ChIP-Seq_VCAP_Human1.25552773
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.24995591
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24082144
70CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22966364
71STAT3_18555785_Chip-Seq_ESCs_Mouse1.22289125
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21774898
73OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20683791
74ETS1_20019798_ChIP-Seq_JURKAT_Human1.20458794
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20047177
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19711342
77SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18192285
78TCF4_22108803_ChIP-Seq_LS180_Human1.18171533
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16972800
80POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16401049
81ETV1_20927104_ChIP-Seq_GIST48_Human1.15212688
82SOX2_18555785_Chip-Seq_ESCs_Mouse1.14888417
83CDX2_22108803_ChIP-Seq_LS180_Human1.14624062
84FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13625842
85OCT4_18555785_Chip-Seq_ESCs_Mouse1.12784602
86TP53_22573176_ChIP-Seq_HFKS_Human1.12763506
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11894618
88SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11307794
89TCF4_23295773_ChIP-Seq_U87_Human1.10971093
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10782891
91EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10219303
92SOX2_19829295_ChIP-Seq_ESCs_Human1.09349682
93NANOG_19829295_ChIP-Seq_ESCs_Human1.09349682
94PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.08894989
95RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08335517
96NOTCH1_21737748_ChIP-Seq_TLL_Human1.07338524
97CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07154045
98JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.06815131
99SRF_21415370_ChIP-Seq_HL-1_Mouse1.06327815
100NMYC_18555785_Chip-Seq_ESCs_Mouse1.06212842

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.40850292
2MP0004885_abnormal_endolymph3.44094671
3MP0003195_calcinosis3.02489018
4MP0002254_reproductive_system_inflammat2.99458470
5MP0008058_abnormal_DNA_repair2.62114009
6MP0002938_white_spotting2.46426639
7MP0006072_abnormal_retinal_apoptosis2.30474631
8MP0008877_abnormal_DNA_methylation2.19509995
9MP0002102_abnormal_ear_morphology2.14668338
10MP0002736_abnormal_nociception_after2.07239126
11MP0005551_abnormal_eye_electrophysiolog2.05667146
12MP0002837_dystrophic_cardiac_calcinosis1.99196352
13MP0005253_abnormal_eye_physiology1.98267560
14MP0008995_early_reproductive_senescence1.93200017
15MP0008875_abnormal_xenobiotic_pharmacok1.82585734
16MP0003718_maternal_effect1.80637736
17MP0000427_abnormal_hair_cycle1.80511163
18MP0003880_abnormal_central_pattern1.78896625
19MP0006292_abnormal_olfactory_placode1.77408310
20MP0002234_abnormal_pharynx_morphology1.75303576
21MP0008057_abnormal_DNA_replication1.74520397
22MP0003787_abnormal_imprinting1.73255905
23MP0003890_abnormal_embryonic-extraembry1.68352175
24MP0010094_abnormal_chromosome_stability1.67454351
25MP0003786_premature_aging1.66955862
26MP0006035_abnormal_mitochondrial_morpho1.58302544
27MP0000647_abnormal_sebaceous_gland1.54253528
28MP0006036_abnormal_mitochondrial_physio1.47418535
29MP0004147_increased_porphyrin_level1.47189751
30MP0002095_abnormal_skin_pigmentation1.46807486
31MP0004742_abnormal_vestibular_system1.45406461
32MP0004215_abnormal_myocardial_fiber1.45223151
33MP0002638_abnormal_pupillary_reflex1.43728041
34MP0009697_abnormal_copulation1.41836897
35MP0001984_abnormal_olfaction1.39284754
36MP0000631_abnormal_neuroendocrine_gland1.39019833
37MP0001968_abnormal_touch/_nociception1.37241648
38MP0005646_abnormal_pituitary_gland1.36824330
39MP0005174_abnormal_tail_pigmentation1.31524972
40MP0005075_abnormal_melanosome_morpholog1.30681448
41MP0001764_abnormal_homeostasis1.30416920
42MP0003806_abnormal_nucleotide_metabolis1.26984216
43MP0000372_irregular_coat_pigmentation1.26676028
44MP0005379_endocrine/exocrine_gland_phen1.23184862
45MP0008872_abnormal_physiological_respon1.22434218
46MP0000015_abnormal_ear_pigmentation1.21860967
47MP0005408_hypopigmentation1.21152786
48MP0001485_abnormal_pinna_reflex1.19979535
49MP0005645_abnormal_hypothalamus_physiol1.13669033
50MP0004133_heterotaxia1.10814033
51MP0001293_anophthalmia1.09758159
52MP0003937_abnormal_limbs/digits/tail_de1.09040604
53MP0002876_abnormal_thyroid_physiology1.05756479
54MP0002163_abnormal_gland_morphology1.05171597
55MP0004019_abnormal_vitamin_homeostasis1.04576861
56MP0002009_preneoplasia1.04550392
57MP0005391_vision/eye_phenotype1.03358622
58MP0005367_renal/urinary_system_phenotyp1.01538610
59MP0000516_abnormal_urinary_system1.01538610
60MP0003186_abnormal_redox_activity0.97563163
61MP0003693_abnormal_embryo_hatching0.97336925
62MP0000383_abnormal_hair_follicle0.94910600
63MP0010678_abnormal_skin_adnexa0.94387675
64MP0002160_abnormal_reproductive_system0.92803352
65MP0001756_abnormal_urination0.92578737
66MP0001929_abnormal_gametogenesis0.91503318
67MP0005187_abnormal_penis_morphology0.90160694
68MP0005195_abnormal_posterior_eye0.89008892
69MP0000653_abnormal_sex_gland0.89000989
70MP0005332_abnormal_amino_acid0.87696642
71MP0003121_genomic_imprinting0.87337769
72MP0003950_abnormal_plasma_membrane0.87112538
73MP0005636_abnormal_mineral_homeostasis0.86535683
74MP0006054_spinal_hemorrhage0.85707860
75MP0001666_abnormal_nutrient_absorption0.85413625
76MP0003698_abnormal_male_reproductive0.84101352
77MP0002751_abnormal_autonomic_nervous0.83899950
78MP0005395_other_phenotype0.82532703
79MP0001529_abnormal_vocalization0.82214432
80MP0004043_abnormal_pH_regulation0.80543378
81MP0001145_abnormal_male_reproductive0.79962100
82MP0003077_abnormal_cell_cycle0.79895166
83MP0002277_abnormal_respiratory_mucosa0.79365058
84MP0002090_abnormal_vision0.78695019
85MP0008007_abnormal_cellular_replicative0.78472653
86MP0002210_abnormal_sex_determination0.78437518
87MP0001944_abnormal_pancreas_morphology0.77734586
88MP0005365_abnormal_bile_salt0.77423225
89MP0010352_gastrointestinal_tract_polyps0.76095112
90MP0002233_abnormal_nose_morphology0.75371063
91MP0001324_abnormal_eye_pigmentation0.75336236
92MP0010329_abnormal_lipoprotein_level0.74032217
93MP0002282_abnormal_trachea_morphology0.73956339
94MP0002177_abnormal_outer_ear0.73070578
95MP0003283_abnormal_digestive_organ0.72802866
96MP0005220_abnormal_exocrine_pancreas0.70369097
97MP0008775_abnormal_heart_ventricle0.69360072
98MP0004085_abnormal_heartbeat0.68035420
99MP0005389_reproductive_system_phenotype0.67448481
100MP0003136_yellow_coat_color0.66606815

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the renal cortex (HP:0011035)4.17175295
2Volvulus (HP:0002580)3.69654996
3Pancreatic fibrosis (HP:0100732)3.43840906
4Pancreatic cysts (HP:0001737)3.29080963
5Abnormality of the renal medulla (HP:0100957)3.27395523
6Abnormality of midbrain morphology (HP:0002418)3.19488354
7Molar tooth sign on MRI (HP:0002419)3.19488354
8True hermaphroditism (HP:0010459)3.08926797
9Conjugated hyperbilirubinemia (HP:0002908)3.01388335
10Nephronophthisis (HP:0000090)2.93910770
11Renal cortical cysts (HP:0000803)2.92263501
12Hypothermia (HP:0002045)2.91106184
13Nephrogenic diabetes insipidus (HP:0009806)2.84928707
14Medial flaring of the eyebrow (HP:0010747)2.71133132
15Chromsome breakage (HP:0040012)2.59875876
16Hypoglycemic seizures (HP:0002173)2.57414807
17Progressive macrocephaly (HP:0004481)2.56691673
18Acute necrotizing encephalopathy (HP:0006965)2.51383613
19Hyperinsulinemic hypoglycemia (HP:0000825)2.50647748
20Congenital stationary night blindness (HP:0007642)2.49307092
21Chromosomal breakage induced by crosslinking agents (HP:0003221)2.45783498
22Acute encephalopathy (HP:0006846)2.41731953
23Hip dysplasia (HP:0001385)2.40408133
24Tubulointerstitial abnormality (HP:0001969)2.35916714
25Tubulointerstitial fibrosis (HP:0005576)2.29613274
26Hypoglycemic coma (HP:0001325)2.28818147
27Mitochondrial inheritance (HP:0001427)2.21995286
28Pancreatic islet-cell hyperplasia (HP:0004510)2.21575942
29Increased CSF lactate (HP:0002490)2.18070842
30Tubular atrophy (HP:0000092)2.15547479
31Abnormality of chromosome stability (HP:0003220)2.14941109
32Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14637563
33Abnormality of alanine metabolism (HP:0010916)2.14637563
34Hyperalaninemia (HP:0003348)2.14637563
35Polyuria (HP:0000103)2.13940297
36Tubulointerstitial nephritis (HP:0001970)2.11164162
37Abnormal mitochondria in muscle tissue (HP:0008316)2.09177897
38Intestinal atresia (HP:0011100)2.08937210
39Oligodactyly (hands) (HP:0001180)2.08510245
40Abnormality of the pons (HP:0007361)2.06432811
41Long clavicles (HP:0000890)2.05659240
42Furrowed tongue (HP:0000221)2.05524525
43Hepatic necrosis (HP:0002605)2.04270044
44Hepatocellular necrosis (HP:0001404)2.03941548
45Aplasia/Hypoplasia of the tongue (HP:0010295)2.03336920
46Hypoplasia of the pons (HP:0012110)1.98015057
47Sloping forehead (HP:0000340)1.97948167
48Abnormal biliary tract physiology (HP:0012439)1.96815147
49Bile duct proliferation (HP:0001408)1.96815147
50Hypokalemic alkalosis (HP:0001949)1.96240051
51Symptomatic seizures (HP:0011145)1.95794814
52Congenital primary aphakia (HP:0007707)1.95715834
53Aplasia/Hypoplasia of the tibia (HP:0005772)1.95704395
54Aplasia/Hypoplasia of the uvula (HP:0010293)1.94784666
55Cerebral edema (HP:0002181)1.94777417
56Oculomotor apraxia (HP:0000657)1.94316206
57Chronic hepatic failure (HP:0100626)1.90991734
58Metaphyseal dysplasia (HP:0100255)1.87202202
59Metabolic alkalosis (HP:0200114)1.85329286
60Gait imbalance (HP:0002141)1.85041097
61Abnormal drinking behavior (HP:0030082)1.84403050
62Polydipsia (HP:0001959)1.84403050
63Genital tract atresia (HP:0001827)1.83273845
64Abnormality of methionine metabolism (HP:0010901)1.81884759
65Abnormality of the ileum (HP:0001549)1.81544249
66Cystic liver disease (HP:0006706)1.80804057
67Meckel diverticulum (HP:0002245)1.80146114
68Small hand (HP:0200055)1.79234690
69Abnormality of the nasal septum (HP:0000419)1.78165728
70Short tibia (HP:0005736)1.78136103
71Cerebral hypomyelination (HP:0006808)1.77105163
72Ketoacidosis (HP:0001993)1.76081415
73Abnormality of aspartate family amino acid metabolism (HP:0010899)1.76004619
74Postaxial foot polydactyly (HP:0001830)1.73436583
75Abnormality of the pancreatic islet cells (HP:0006476)1.72827323
76Abnormality of endocrine pancreas physiology (HP:0012093)1.72827323
77Abnormality of renal excretion (HP:0011036)1.72649231
78Pheochromocytoma (HP:0002666)1.72462796
79Hypoplasia of the fovea (HP:0007750)1.71205869
80Aplasia/Hypoplasia of the fovea (HP:0008060)1.71205869
81Abnormality of the labia minora (HP:0012880)1.70659381
82Pendular nystagmus (HP:0012043)1.70347843
83Hypoplastic labia majora (HP:0000059)1.70317721
84Fair hair (HP:0002286)1.69902906
85Congenital, generalized hypertrichosis (HP:0004540)1.69900341
86Abnormality of macular pigmentation (HP:0008002)1.69704996
87Abnormal urine output (HP:0012590)1.69181629
88Abnormality of the preputium (HP:0100587)1.68012118
89Neoplasm of the adrenal gland (HP:0100631)1.67972351
90Narrow forehead (HP:0000341)1.67734455
91Astigmatism (HP:0000483)1.67048989
92Increased serum pyruvate (HP:0003542)1.66869075
93Cutaneous melanoma (HP:0012056)1.65899040
94Fibular hypoplasia (HP:0003038)1.65021268
95Sclerocornea (HP:0000647)1.64755010
96Type I transferrin isoform profile (HP:0003642)1.63747524
97Abolished electroretinogram (ERG) (HP:0000550)1.63349751
98CNS demyelination (HP:0007305)1.62706554
99Methylmalonic acidemia (HP:0002912)1.62287132
100Chorioretinal atrophy (HP:0000533)1.61210405

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.45164902
2NUAK13.66793848
3LATS12.68003225
4MAP4K22.55647053
5BRSK22.49409834
6TRIM282.43006154
7BMPR1B2.34646949
8MST42.29320587
9EIF2AK32.28647324
10EIF2AK12.27673146
11WNK32.26918878
12MKNK22.13297872
13WEE12.10863039
14TNIK1.83411185
15ACVR1B1.83159018
16INSRR1.79919921
17ZAK1.79282931
18STK31.73708150
19AKT31.72637326
20STK391.69600378
21PLK41.69529718
22PNCK1.60652544
23CASK1.58875088
24MKNK11.58526971
25ERBB31.57348915
26BCR1.51755217
27GRK11.45069561
28PLK31.44653235
29ADRBK21.44577435
30NLK1.43168602
31OXSR11.40477234
32TSSK61.28593351
33CSNK1G11.27573937
34SIK31.21623372
35STK38L1.17681514
36CDK31.17382093
37SRPK11.14148420
38CDC71.11954052
39TTK1.11031284
40NEK11.07690136
41FLT31.05192924
42FGFR31.03983731
43FGFR21.02239969
44PLK21.00944349
45PAK30.98877193
46PBK0.97327618
47FER0.93842801
48MAPK130.91113312
49MAP3K40.85118759
50FGFR10.80930460
51VRK10.72451078
52PINK10.69732414
53NME10.68048476
54PRKCE0.68043124
55WNK40.67905982
56BUB10.67834178
57PLK10.67121727
58STK160.63616861
59TEC0.63260966
60EIF2AK20.62208307
61ATM0.60823576
62PTK2B0.60472336
63CCNB10.57686352
64MAP2K60.54644767
65ERBB40.53704040
66MUSK0.53657629
67YES10.53026698
68PHKG20.50381308
69PHKG10.50381308
70SGK20.49477745
71NTRK30.49383875
72CSNK1G30.49333792
73BRSK10.49012248
74ATR0.48875745
75BRD40.48746656
76PDK20.47304969
77CSNK1G20.42466766
78CSNK1E0.42117722
79EPHA40.38892768
80TGFBR10.38243488
81CSNK1A1L0.36843109
82AURKB0.36403145
83CSNK1A10.35869121
84CAMK1G0.33590437
85PRKCG0.33247878
86ADRBK10.32020848
87MARK30.31021237
88TIE10.30639391
89STK40.29481109
90CHEK10.29326883
91PIK3CA0.29276139
92ERBB20.28265934
93CSNK2A10.28008351
94TLK10.27959673
95PRKAA20.27575579
96CSNK2A20.27153921
97STK240.26946317
98MAP3K20.25608604
99CAMK2D0.25570971
100MAP3K120.25153838

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.83321422
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.10021298
3Proteasome_Homo sapiens_hsa030502.53932630
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.40951431
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.30938628
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.29568733
7Non-homologous end-joining_Homo sapiens_hsa034502.26446394
8Fanconi anemia pathway_Homo sapiens_hsa034602.23538823
9Homologous recombination_Homo sapiens_hsa034402.23364471
10Butanoate metabolism_Homo sapiens_hsa006502.19840216
11Selenocompound metabolism_Homo sapiens_hsa004501.95431014
12One carbon pool by folate_Homo sapiens_hsa006701.91039429
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.85929696
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.85548022
15Propanoate metabolism_Homo sapiens_hsa006401.85123547
16Nitrogen metabolism_Homo sapiens_hsa009101.82761286
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.81138406
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.77630640
19Oxidative phosphorylation_Homo sapiens_hsa001901.76596921
20RNA polymerase_Homo sapiens_hsa030201.74480811
21Phototransduction_Homo sapiens_hsa047441.69812982
22Basal transcription factors_Homo sapiens_hsa030221.67663323
23Caffeine metabolism_Homo sapiens_hsa002321.66630443
24Steroid biosynthesis_Homo sapiens_hsa001001.62649668
25RNA degradation_Homo sapiens_hsa030181.61214789
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.49061186
27RNA transport_Homo sapiens_hsa030131.48089468
28Mismatch repair_Homo sapiens_hsa034301.47661676
29Linoleic acid metabolism_Homo sapiens_hsa005911.42230315
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.40973469
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.36033949
32Fatty acid elongation_Homo sapiens_hsa000621.35532173
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.27306540
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.25810053
35Ether lipid metabolism_Homo sapiens_hsa005651.25537937
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25008983
37Chemical carcinogenesis_Homo sapiens_hsa052041.22049488
38Tryptophan metabolism_Homo sapiens_hsa003801.21753391
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.20345234
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.18741913
41Retinol metabolism_Homo sapiens_hsa008301.15260288
42Spliceosome_Homo sapiens_hsa030401.14765466
43Parkinsons disease_Homo sapiens_hsa050121.13822012
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.10384010
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10326821
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08765394
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07852429
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.07589272
49Base excision repair_Homo sapiens_hsa034101.07003726
50Circadian rhythm_Homo sapiens_hsa047101.05588916
51Sulfur metabolism_Homo sapiens_hsa009201.03754921
52Peroxisome_Homo sapiens_hsa041460.96825824
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96306916
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96247981
55Purine metabolism_Homo sapiens_hsa002300.95212018
56Fatty acid degradation_Homo sapiens_hsa000710.93185666
57Nucleotide excision repair_Homo sapiens_hsa034200.88901227
58Collecting duct acid secretion_Homo sapiens_hsa049660.85242200
59Pyrimidine metabolism_Homo sapiens_hsa002400.82986783
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82477394
61Huntingtons disease_Homo sapiens_hsa050160.82444545
62Glutathione metabolism_Homo sapiens_hsa004800.80242801
63Vitamin B6 metabolism_Homo sapiens_hsa007500.80157924
64Pyruvate metabolism_Homo sapiens_hsa006200.78107591
65Fat digestion and absorption_Homo sapiens_hsa049750.76914886
66Metabolic pathways_Homo sapiens_hsa011000.74546578
67mRNA surveillance pathway_Homo sapiens_hsa030150.73904720
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.73798576
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71731450
70Fatty acid metabolism_Homo sapiens_hsa012120.71213576
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70334159
72ABC transporters_Homo sapiens_hsa020100.69818648
73Folate biosynthesis_Homo sapiens_hsa007900.69536028
74DNA replication_Homo sapiens_hsa030300.69196443
75Mineral absorption_Homo sapiens_hsa049780.64706675
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64143952
77beta-Alanine metabolism_Homo sapiens_hsa004100.62596517
78Cell cycle_Homo sapiens_hsa041100.61894778
79Regulation of autophagy_Homo sapiens_hsa041400.59973212
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59380215
81Alzheimers disease_Homo sapiens_hsa050100.57138678
82Sphingolipid metabolism_Homo sapiens_hsa006000.55672268
83Oocyte meiosis_Homo sapiens_hsa041140.54883687
84Olfactory transduction_Homo sapiens_hsa047400.54671253
85N-Glycan biosynthesis_Homo sapiens_hsa005100.54621990
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54462977
87Tyrosine metabolism_Homo sapiens_hsa003500.54258919
88Vitamin digestion and absorption_Homo sapiens_hsa049770.54043704
89p53 signaling pathway_Homo sapiens_hsa041150.53277495
90Glycerolipid metabolism_Homo sapiens_hsa005610.50906038
91Taste transduction_Homo sapiens_hsa047420.48185162
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46528375
93Nicotine addiction_Homo sapiens_hsa050330.44559520
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41271481
95Arachidonic acid metabolism_Homo sapiens_hsa005900.37396474
96Lysine degradation_Homo sapiens_hsa003100.37262181
97Histidine metabolism_Homo sapiens_hsa003400.36820753
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36308811
99Arginine and proline metabolism_Homo sapiens_hsa003300.35328926
100TGF-beta signaling pathway_Homo sapiens_hsa043500.33154926

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