C1ORF226

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.93260743
2L-serine metabolic process (GO:0006563)3.88458961
3nucleobase catabolic process (GO:0046113)3.83890967
4paraxial mesoderm development (GO:0048339)3.68773922
5axon extension involved in axon guidance (GO:0048846)3.56331239
6neuron projection extension involved in neuron projection guidance (GO:1902284)3.56331239
7presynaptic membrane organization (GO:0097090)3.47405206
8embryonic retina morphogenesis in camera-type eye (GO:0060059)3.46124418
9serine family amino acid catabolic process (GO:0009071)3.17386986
10presynaptic membrane assembly (GO:0097105)3.14778010
11ganglion development (GO:0061548)3.04077156
12neuron recognition (GO:0008038)3.03042147
13substrate-independent telencephalic tangential migration (GO:0021826)2.92582865
14substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.92582865
15serine family amino acid biosynthetic process (GO:0009070)2.84184571
16glyoxylate metabolic process (GO:0046487)2.83384713
17axonal fasciculation (GO:0007413)2.80728721
18apical protein localization (GO:0045176)2.77443309
19planar cell polarity pathway involved in neural tube closure (GO:0090179)2.73969877
20lateral sprouting from an epithelium (GO:0060601)2.67518822
21G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.65180963
22glycine metabolic process (GO:0006544)2.63147452
23ectodermal placode formation (GO:0060788)2.62844276
24retinal ganglion cell axon guidance (GO:0031290)2.60473602
25exogenous drug catabolic process (GO:0042738)2.55652652
26regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.53770917
27serine family amino acid metabolic process (GO:0009069)2.51510756
28regulation of DNA methylation (GO:0044030)2.47556745
29regulation of bile acid biosynthetic process (GO:0070857)2.45510027
30pre-miRNA processing (GO:0031054)2.38753604
31negative regulation of axon guidance (GO:1902668)2.37795046
32protein localization to kinetochore (GO:0034501)2.36845898
33cholesterol biosynthetic process (GO:0006695)2.36126160
34cellular glucuronidation (GO:0052695)2.34988961
35negative regulation of catecholamine secretion (GO:0033604)2.34353632
36establishment of planar polarity (GO:0001736)2.31205658
37establishment of tissue polarity (GO:0007164)2.31205658
38intraciliary transport (GO:0042073)2.30435059
39cranial nerve development (GO:0021545)2.29639000
40convergent extension (GO:0060026)2.29276814
41ephrin receptor signaling pathway (GO:0048013)2.25335463
42regulation of axon guidance (GO:1902667)2.24627179
43camera-type eye morphogenesis (GO:0048593)2.24258392
44regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.24075236
45olfactory bulb development (GO:0021772)2.23412387
46axon extension (GO:0048675)2.23274098
47establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.23162417
48asymmetric protein localization (GO:0008105)2.22966381
49negative regulation of axon extension involved in axon guidance (GO:0048843)2.22743401
50establishment or maintenance of apical/basal cell polarity (GO:0035088)2.22699883
51establishment or maintenance of bipolar cell polarity (GO:0061245)2.22699883
52establishment of nucleus localization (GO:0040023)2.22392706
53postsynaptic membrane organization (GO:0001941)2.21457401
54heterochromatin organization (GO:0070828)2.20953121
55notochord development (GO:0030903)2.20664854
56mesenchymal to epithelial transition (GO:0060231)2.20025353
57glucuronate metabolic process (GO:0019585)2.19853600
58uronic acid metabolic process (GO:0006063)2.19853600
59body morphogenesis (GO:0010171)2.19799475
60regulation of acrosome reaction (GO:0060046)2.19131742
61RNA localization (GO:0006403)2.19045801
62outer ear morphogenesis (GO:0042473)2.18206948
63cellular response to cholesterol (GO:0071397)2.17598613
64urea metabolic process (GO:0019627)2.17488883
65epoxygenase P450 pathway (GO:0019373)2.17412728
66Sertoli cell development (GO:0060009)2.17191826
67chromatin remodeling at centromere (GO:0031055)2.17038980
68regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.16675012
69regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.16290225
70sterol biosynthetic process (GO:0016126)2.15297036
71drug catabolic process (GO:0042737)2.14200231
72regulation of axon extension involved in axon guidance (GO:0048841)2.13840477
73DNA replication-independent nucleosome assembly (GO:0006336)2.13743211
74DNA replication-independent nucleosome organization (GO:0034724)2.13743211
75labyrinthine layer development (GO:0060711)2.13717842
76limb bud formation (GO:0060174)2.12906291
77positive regulation of gastrulation (GO:2000543)2.11788349
78amino-acid betaine metabolic process (GO:0006577)2.09887670
79CENP-A containing nucleosome assembly (GO:0034080)2.07813623
80Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.07775694
81regulation of neuron migration (GO:2001222)2.07264568
82positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.06100899
83developmental cell growth (GO:0048588)2.05148600
84C4-dicarboxylate transport (GO:0015740)2.04160290
85spinal cord development (GO:0021510)2.03191391
86layer formation in cerebral cortex (GO:0021819)2.01068700
87mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.01042727
88neuron projection extension (GO:1990138)2.00609785
89neuronal stem cell maintenance (GO:0097150)1.99449595
90peptidyl-glutamic acid carboxylation (GO:0017187)1.99047175
91protein carboxylation (GO:0018214)1.99047175
92post-anal tail morphogenesis (GO:0036342)1.99043881
93negative regulation of lipase activity (GO:0060192)1.98954249
94regulation of establishment of planar polarity (GO:0090175)1.98358683
95thalamus development (GO:0021794)1.96032327
96vocalization behavior (GO:0071625)1.95160154
97cell-cell junction maintenance (GO:0045217)1.94907580
98regulation of fibrinolysis (GO:0051917)1.94538792
99neuron migration (GO:0001764)1.94507411
100biotin metabolic process (GO:0006768)1.94439663

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.81216699
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.53222340
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.89973010
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.76480309
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.74871040
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.52482259
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.18412638
8ESR1_15608294_ChIP-ChIP_MCF-7_Human2.12142047
9NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.05244847
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.03817198
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.03817198
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.03817198
13E2F7_22180533_ChIP-Seq_HELA_Human1.97686252
14FOXM1_23109430_ChIP-Seq_U2OS_Human1.91701844
15GATA1_26923725_Chip-Seq_HPCs_Mouse1.78365835
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.77623175
17ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.75276616
18POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.70799500
19AR_21909140_ChIP-Seq_LNCAP_Human1.59548580
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.58724794
21SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.52805575
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.50362395
23ESR1_21235772_ChIP-Seq_MCF-7_Human1.49754639
24SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.46037472
25RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.45982013
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45519417
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.41505204
28ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33446351
29ISL1_27105846_Chip-Seq_CPCs_Mouse1.30081795
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.29798725
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.29798725
32SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28447230
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.27090982
34POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26678101
35STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.24779510
36ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24534800
37POU5F1_16518401_ChIP-PET_MESCs_Mouse1.23884925
38OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.23566459
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.21366497
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.18736178
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.18589597
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16853630
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.16825475
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15728940
45TBX3_20139965_ChIP-Seq_ESCs_Mouse1.15147597
46EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14096909
47TBX3_20139965_ChIP-Seq_MESCs_Mouse1.14013182
48CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12254555
49RING1B_27294783_Chip-Seq_NPCs_Mouse1.11881950
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.09444668
51RNF2_27304074_Chip-Seq_NSC_Mouse1.06700024
52NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.06406701
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.05563392
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05175815
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05134583
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05134583
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04165163
58FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.03419887
59TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02679982
60CDX2_20551321_ChIP-Seq_CACO-2_Human1.01984221
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.00434091
62RNF2_27304074_Chip-Seq_ESCs_Mouse0.99806673
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98671991
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97618305
65SOX2_16153702_ChIP-ChIP_HESCs_Human0.97089952
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95784677
67JARID2_20064375_ChIP-Seq_MESCs_Mouse0.94959445
68NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.94668357
69REST_21632747_ChIP-Seq_MESCs_Mouse0.94314958
70NANOG_16153702_ChIP-ChIP_HESCs_Human0.94153234
71POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.93886800
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93503014
73FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92928440
74TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92407376
75PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91706236
76ESR1_20079471_ChIP-ChIP_T-47D_Human0.90967296
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90719197
78SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.90113883
79ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90022294
80ZNF263_19887448_ChIP-Seq_K562_Human0.89563720
81KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.89550828
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89138363
83CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.88216994
84KDM2B_26808549_Chip-Seq_K562_Human0.87348145
85KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.87203949
86POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.85883084
87ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85663523
88TP53_20018659_ChIP-ChIP_R1E_Mouse0.85593610
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85045965
90TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.82456372
91MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.82087973
92TCF3_18692474_ChIP-Seq_MESCs_Mouse0.81023487
93SMAD3_21741376_ChIP-Seq_ESCs_Human0.80736065
94SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.79649083
95EP300_21415370_ChIP-Seq_HL-1_Mouse0.78692312
96JARID2_20075857_ChIP-Seq_MESCs_Mouse0.77333437
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77218632
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.77210295
99TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.76067717
100PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.76063140

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy4.20346137
2MP0000566_synostosis3.01526108
3MP0003123_paternal_imprinting2.97731173
4MP0010030_abnormal_orbit_morphology2.51078551
5MP0000778_abnormal_nervous_system2.33043999
6MP0003941_abnormal_skin_development2.31329851
7MP0002653_abnormal_ependyma_morphology2.26818628
8MP0003718_maternal_effect2.21045181
9MP0002139_abnormal_hepatobiliary_system2.11878849
10MP0006292_abnormal_olfactory_placode2.10732359
11MP0000537_abnormal_urethra_morphology2.03608940
12MP0003880_abnormal_central_pattern1.97356551
13MP0008789_abnormal_olfactory_epithelium1.90765636
14MP0003890_abnormal_embryonic-extraembry1.90758837
15MP0001293_anophthalmia1.90015184
16MP0003121_genomic_imprinting1.82320250
17MP0005499_abnormal_olfactory_system1.81725962
18MP0005394_taste/olfaction_phenotype1.81725962
19MP0003122_maternal_imprinting1.70578558
20MP0002233_abnormal_nose_morphology1.64477375
21MP0002249_abnormal_larynx_morphology1.61394367
22MP0001529_abnormal_vocalization1.55557328
23MP0003942_abnormal_urinary_system1.52439518
24MP0005085_abnormal_gallbladder_physiolo1.51894547
25MP0002697_abnormal_eye_size1.51471663
26MP0009053_abnormal_anal_canal1.48105674
27MP0001286_abnormal_eye_development1.45553997
28MP0003937_abnormal_limbs/digits/tail_de1.44802771
29MP0003861_abnormal_nervous_system1.38341927
30MP0005423_abnormal_somatic_nervous1.37941300
31MP0000049_abnormal_middle_ear1.37122586
32MP0003755_abnormal_palate_morphology1.35010111
33MP0000534_abnormal_ureter_morphology1.34047623
34MP0005365_abnormal_bile_salt1.31321414
35MP0003119_abnormal_digestive_system1.27277033
36MP0000955_abnormal_spinal_cord1.26177783
37MP0001188_hyperpigmentation1.25941604
38MP0008932_abnormal_embryonic_tissue1.23674634
39MP0001666_abnormal_nutrient_absorption1.20245286
40MP0004859_abnormal_synaptic_plasticity1.17249556
41MP0000579_abnormal_nail_morphology1.14581111
42MP0009672_abnormal_birth_weight1.14244387
43MP0006276_abnormal_autonomic_nervous1.13565262
44MP0005248_abnormal_Harderian_gland1.12593018
45MP0002092_abnormal_eye_morphology1.10907579
46MP0000631_abnormal_neuroendocrine_gland1.10635324
47MP0004133_heterotaxia1.10129242
48MP0000762_abnormal_tongue_morphology1.09769018
49MP0002751_abnormal_autonomic_nervous1.08974168
50MP0009379_abnormal_foot_pigmentation1.08384873
51MP0005360_urolithiasis1.04284335
52MP0003935_abnormal_craniofacial_develop1.03644523
53MP0002116_abnormal_craniofacial_bone1.03294954
54MP0003938_abnormal_ear_development1.03215785
55MP0003136_yellow_coat_color1.02943330
56MP0002152_abnormal_brain_morphology1.01767807
57MP0002085_abnormal_embryonic_tissue1.00401020
58MP0003567_abnormal_fetal_cardiomyocyte0.99799066
59MP0002184_abnormal_innervation0.97799534
60MP0002938_white_spotting0.96584770
61MP0002282_abnormal_trachea_morphology0.95594785
62MP0004885_abnormal_endolymph0.94863015
63MP0000428_abnormal_craniofacial_morphol0.92964921
64MP0003693_abnormal_embryo_hatching0.92655013
65MP0004270_analgesia0.88779578
66MP0005076_abnormal_cell_differentiation0.88232167
67MP0002111_abnormal_tail_morphology0.87771379
68MP0000026_abnormal_inner_ear0.86944970
69MP0002084_abnormal_developmental_patter0.86787567
70MP0002752_abnormal_somatic_nervous0.86495270
71MP0003868_abnormal_feces_composition0.85530224
72MP0003385_abnormal_body_wall0.85490001
73MP0005367_renal/urinary_system_phenotyp0.84805480
74MP0000516_abnormal_urinary_system0.84805480
75MP0003315_abnormal_perineum_morphology0.84710164
76MP0002736_abnormal_nociception_after0.84058387
77MP0005257_abnormal_intraocular_pressure0.83364760
78MP0004957_abnormal_blastocyst_morpholog0.83035205
79MP0005187_abnormal_penis_morphology0.80520675
80MP0000432_abnormal_head_morphology0.80230869
81MP0009250_abnormal_appendicular_skeleto0.79803743
82MP0005377_hearing/vestibular/ear_phenot0.79058064
83MP0003878_abnormal_ear_physiology0.79058064
84MP0002081_perinatal_lethality0.78910286
85MP0002882_abnormal_neuron_morphology0.78544800
86MP0004264_abnormal_extraembryonic_tissu0.78422309
87MP0001984_abnormal_olfaction0.76688879
88MP0002735_abnormal_chemical_nociception0.75747632
89MP0009703_decreased_birth_body0.74630789
90MP0002089_abnormal_postnatal_growth/wei0.71840458
91MP0005395_other_phenotype0.71441520
92MP0005409_darkened_coat_color0.71225721
93MP0004858_abnormal_nervous_system0.69999914
94MP0003011_delayed_dark_adaptation0.69907799
95MP0001672_abnormal_embryogenesis/_devel0.69305048
96MP0005380_embryogenesis_phenotype0.69305048
97MP0002909_abnormal_adrenal_gland0.68803102
98MP0008875_abnormal_xenobiotic_pharmacok0.68718649
99MP0005670_abnormal_white_adipose0.68510268
100MP0003115_abnormal_respiratory_system0.68116808

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)4.55418230
2Hepatoblastoma (HP:0002884)3.34943096
3Myokymia (HP:0002411)3.07076794
4Hyperglycinemia (HP:0002154)3.04585163
5Cortical dysplasia (HP:0002539)2.96612768
6Deep venous thrombosis (HP:0002625)2.88504035
7Abnormality of the labia minora (HP:0012880)2.84742655
8Abnormality of monocarboxylic acid metabolism (HP:0010996)2.78537636
9Absent septum pellucidum (HP:0001331)2.72620743
10Aplasia/Hypoplasia of the sternum (HP:0006714)2.63932557
11Maternal diabetes (HP:0009800)2.55756984
12Bifid scrotum (HP:0000048)2.47474044
13Abnormality of serine family amino acid metabolism (HP:0010894)2.44070789
14Abnormality of glycine metabolism (HP:0010895)2.44070789
15Partial duplication of thumb phalanx (HP:0009944)2.42574517
16Choanal stenosis (HP:0000452)2.38205650
17Intrahepatic cholestasis (HP:0001406)2.33938631
18Abnormality of the septum pellucidum (HP:0007375)2.33933752
19Hyperglycinuria (HP:0003108)2.32991981
20Osteomalacia (HP:0002749)2.26962871
21Turricephaly (HP:0000262)2.25906163
22Prolonged partial thromboplastin time (HP:0003645)2.25640903
23Anophthalmia (HP:0000528)2.20337609
24Facial hemangioma (HP:0000329)2.15101087
25Bifid tongue (HP:0010297)2.14616178
26Cutaneous finger syndactyly (HP:0010554)2.13584903
27Bronchomalacia (HP:0002780)2.12480816
28Partial duplication of the phalanx of hand (HP:0009999)2.10806101
29Split foot (HP:0001839)2.09771935
30Optic nerve hypoplasia (HP:0000609)2.09513162
31Myelomeningocele (HP:0002475)2.09232048
32Bicornuate uterus (HP:0000813)2.08869267
33Oligodactyly (HP:0012165)2.03173756
34Renal hypoplasia (HP:0000089)2.01977806
35Hypobetalipoproteinemia (HP:0003563)2.00491130
36Abnormal lung lobation (HP:0002101)1.99411081
37Cutaneous syndactyly (HP:0012725)1.98861635
38Oligodactyly (hands) (HP:0001180)1.97397779
39Increased nuchal translucency (HP:0010880)1.93093681
40Conjugated hyperbilirubinemia (HP:0002908)1.91312425
41Papillary thyroid carcinoma (HP:0002895)1.88036270
42Hypophosphatemic rickets (HP:0004912)1.84190472
43Scrotal hypoplasia (HP:0000046)1.82442804
44Hemivertebrae (HP:0002937)1.82070480
45High anterior hairline (HP:0009890)1.81490066
46Hypercholesterolemia (HP:0003124)1.81200483
47Shallow orbits (HP:0000586)1.80440201
48Coronal craniosynostosis (HP:0004440)1.79718179
49Morphological abnormality of the middle ear (HP:0008609)1.78989267
50Renal dysplasia (HP:0000110)1.78648834
51Impulsivity (HP:0100710)1.78610231
52Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78046835
53Absent eyebrow (HP:0002223)1.77564684
54Labial hypoplasia (HP:0000066)1.76837804
55Leiomyosarcoma (HP:0100243)1.76311717
56Uterine leiomyosarcoma (HP:0002891)1.76311717
57Complement deficiency (HP:0004431)1.75084794
58Esophageal atresia (HP:0002032)1.73360049
59Abnormality of aromatic amino acid family metabolism (HP:0004338)1.72494130
60Megalencephaly (HP:0001355)1.71939931
61Supernumerary spleens (HP:0009799)1.71659570
62Hypoplastic female external genitalia (HP:0012815)1.70610921
63Pterygium (HP:0001059)1.67681816
64Midline defect of the nose (HP:0004122)1.67274549
65Rib fusion (HP:0000902)1.67135321
66Micropenis (HP:0000054)1.65714819
67Trigonocephaly (HP:0000243)1.65238207
68Colon cancer (HP:0003003)1.63819299
69Growth hormone deficiency (HP:0000824)1.60406289
70Enlarged penis (HP:0000040)1.58695713
71Hypoplasia of the brainstem (HP:0002365)1.57674342
72Aplasia/Hypoplasia of the brainstem (HP:0007362)1.57674342
73Facial cleft (HP:0002006)1.53681140
74Omphalocele (HP:0001539)1.53318344
75Retinal dysplasia (HP:0007973)1.53102367
76Overlapping toe (HP:0001845)1.51763516
77Aplasia/Hypoplasia of the breasts (HP:0010311)1.49010279
78Breast aplasia (HP:0100783)1.48844766
79Meningocele (HP:0002435)1.48206834
80Abnormality of methionine metabolism (HP:0010901)1.47240787
81Abnormal urine phosphate concentration (HP:0012599)1.46276766
82Increased serum pyruvate (HP:0003542)1.44796899
83Abnormality of the labia (HP:0000058)1.44206881
84Duplication of thumb phalanx (HP:0009942)1.44168024
85Vitreoretinal degeneration (HP:0000655)1.43822329
86Malignant gastrointestinal tract tumors (HP:0006749)1.43066644
87Gastrointestinal carcinoma (HP:0002672)1.43066644
88Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.42941356
89Abnormality of the diencephalon (HP:0010662)1.42900512
90Hyperphosphaturia (HP:0003109)1.42578380
91Abnormality of serum amino acid levels (HP:0003112)1.41823635
92Arnold-Chiari malformation (HP:0002308)1.41244542
93Neoplasm of the liver (HP:0002896)1.41213302
94Rhabdomyosarcoma (HP:0002859)1.40964371
95Hypolipoproteinemia (HP:0010981)1.40829682
96Hypoplastic pelvis (HP:0008839)1.39606607
97Abnormality of the lacrimal duct (HP:0011481)1.39326538
98Chronic hepatic failure (HP:0100626)1.39311412
99Abnormality of aspartate family amino acid metabolism (HP:0010899)1.39282553
100Bilateral microphthalmos (HP:0007633)1.37205572

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.09350560
2TNIK2.76337028
3ICK2.56604616
4TTK2.41711234
5STK162.39168250
6DYRK22.36112635
7EPHA22.32104029
8EPHB22.20310014
9MARK12.12351972
10SIK12.05246543
11TRIB32.03214623
12RIPK11.97504362
13NTRK21.93986973
14MAP3K91.92710034
15MET1.85735282
16NME11.73741599
17DMPK1.56544911
18SRPK11.54580875
19NTRK11.44263508
20BCR1.29202965
21MKNK21.28409056
22WNK31.27266504
23BUB11.25452993
24MAP3K101.24241828
25BRD41.21951216
26NTRK31.21246358
27TYRO31.17191423
28TRIM281.14040736
29PNCK1.11756104
30DYRK31.03420887
31MAP3K41.01901151
32MINK10.99932854
33CAMK1G0.99717300
34PLK10.98539193
35CSNK1G20.98365805
36NEK60.98093685
37DYRK1B0.97470407
38LATS10.97066523
39FGFR10.96866064
40CDK70.96268755
41CAMK1D0.95690148
42TSSK60.94426919
43FGFR20.93922743
44PTK20.93906104
45LMTK20.93847909
46STK38L0.92780273
47PBK0.91424844
48MAPK150.89473301
49BCKDK0.89365108
50WEE10.88963291
51MKNK10.88494247
52LATS20.88144421
53MAP2K70.87942750
54PLK30.86123001
55MTOR0.84316506
56CDC70.84269516
57TAF10.83982862
58PDGFRA0.81987406
59CSNK1G10.81238916
60STK390.79487809
61BMPR1B0.79205704
62ERBB20.79045523
63CDK120.76870164
64MST1R0.73270695
65VRK20.71057014
66BRSK10.70542241
67CSNK1E0.68784940
68PRKCG0.68578112
69AURKA0.67778655
70SMG10.67480506
71WNK40.67180689
72NUAK10.64453321
73ERBB40.63358848
74CDK90.63199158
75PKN20.62279858
76CSNK1G30.60652155
77CSNK1A1L0.60121402
78EEF2K0.60071065
79MUSK0.54253421
80INSRR0.52745148
81CDK10.51618036
82BRSK20.51212846
83PRKD30.51115686
84PIK3CA0.50394198
85CDK150.49998475
86CDK180.49756659
87STK240.48418634
88DYRK1A0.47800651
89AURKB0.47164313
90PTK60.45457698
91FGFR40.45315534
92CDK50.44791483
93ZAK0.44551199
94CHEK20.44545680
95SGK2230.44435419
96SGK4940.44435419
97PRKDC0.44184617
98MAP2K40.43836670
99CDK20.43728956
100CDK11A0.43492604

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.39488775
2Caffeine metabolism_Homo sapiens_hsa002322.36072383
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.33528419
4Steroid biosynthesis_Homo sapiens_hsa001002.14429463
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.12123330
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.00598526
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.99668109
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87998706
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.74590359
10Retinol metabolism_Homo sapiens_hsa008301.70111453
11Primary bile acid biosynthesis_Homo sapiens_hsa001201.64879540
12Vitamin B6 metabolism_Homo sapiens_hsa007501.63144733
13Pentose and glucuronate interconversions_Homo sapiens_hsa000401.57785006
14Cysteine and methionine metabolism_Homo sapiens_hsa002701.57732125
15Basal cell carcinoma_Homo sapiens_hsa052171.57499191
16Propanoate metabolism_Homo sapiens_hsa006401.47944809
17Axon guidance_Homo sapiens_hsa043601.43754678
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.42625380
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.40262509
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39244131
21Biosynthesis of amino acids_Homo sapiens_hsa012301.38436801
22Pyruvate metabolism_Homo sapiens_hsa006201.38279803
23Arginine biosynthesis_Homo sapiens_hsa002201.38042309
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35840940
25Phenylalanine metabolism_Homo sapiens_hsa003601.34366254
26Butanoate metabolism_Homo sapiens_hsa006501.33881429
27Bile secretion_Homo sapiens_hsa049761.30109396
28Chemical carcinogenesis_Homo sapiens_hsa052041.28358098
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23905489
30Complement and coagulation cascades_Homo sapiens_hsa046101.20082113
31Fatty acid degradation_Homo sapiens_hsa000711.18747746
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.17840200
33Hedgehog signaling pathway_Homo sapiens_hsa043401.16610985
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.13921904
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.12363662
36Notch signaling pathway_Homo sapiens_hsa043301.08667584
37Mismatch repair_Homo sapiens_hsa034301.08646007
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.07502311
39Lysine degradation_Homo sapiens_hsa003101.07394301
40Hippo signaling pathway_Homo sapiens_hsa043901.07024120
41Fatty acid metabolism_Homo sapiens_hsa012121.06164897
42Basal transcription factors_Homo sapiens_hsa030221.04315710
43Fatty acid elongation_Homo sapiens_hsa000621.03768293
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00137945
45Tyrosine metabolism_Homo sapiens_hsa003500.98507558
46Cell cycle_Homo sapiens_hsa041100.98161764
47Fat digestion and absorption_Homo sapiens_hsa049750.96898878
48Carbon metabolism_Homo sapiens_hsa012000.96431230
49PPAR signaling pathway_Homo sapiens_hsa033200.96380625
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92985049
51Histidine metabolism_Homo sapiens_hsa003400.92688714
52Arginine and proline metabolism_Homo sapiens_hsa003300.92531572
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88000727
54Adherens junction_Homo sapiens_hsa045200.87743560
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84679231
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83878743
57Starch and sucrose metabolism_Homo sapiens_hsa005000.81721596
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81193381
59Wnt signaling pathway_Homo sapiens_hsa043100.81032864
60Base excision repair_Homo sapiens_hsa034100.79412573
61Endometrial cancer_Homo sapiens_hsa052130.78796455
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74631836
63Gap junction_Homo sapiens_hsa045400.73811213
64Thyroid cancer_Homo sapiens_hsa052160.73323869
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73096821
66Tight junction_Homo sapiens_hsa045300.70277338
67Linoleic acid metabolism_Homo sapiens_hsa005910.69769054
68Folate biosynthesis_Homo sapiens_hsa007900.65079536
69Peroxisome_Homo sapiens_hsa041460.64597119
70beta-Alanine metabolism_Homo sapiens_hsa004100.64003286
71Tryptophan metabolism_Homo sapiens_hsa003800.62716701
72mRNA surveillance pathway_Homo sapiens_hsa030150.60976816
73Nicotine addiction_Homo sapiens_hsa050330.60899260
74Vitamin digestion and absorption_Homo sapiens_hsa049770.56071308
75DNA replication_Homo sapiens_hsa030300.55992728
76Nucleotide excision repair_Homo sapiens_hsa034200.54272083
77Nitrogen metabolism_Homo sapiens_hsa009100.53102853
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.52798468
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52334299
80Colorectal cancer_Homo sapiens_hsa052100.50173550
81MicroRNAs in cancer_Homo sapiens_hsa052060.49109228
82RNA transport_Homo sapiens_hsa030130.48667418
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48215784
84Cocaine addiction_Homo sapiens_hsa050300.47894196
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47782534
86Sulfur relay system_Homo sapiens_hsa041220.47226743
87Melanogenesis_Homo sapiens_hsa049160.47214956
88Metabolic pathways_Homo sapiens_hsa011000.45277400
89Oocyte meiosis_Homo sapiens_hsa041140.45207380
90AMPK signaling pathway_Homo sapiens_hsa041520.44662157
91Non-homologous end-joining_Homo sapiens_hsa034500.44250547
92Fanconi anemia pathway_Homo sapiens_hsa034600.42737402
93Glutamatergic synapse_Homo sapiens_hsa047240.41535050
94ErbB signaling pathway_Homo sapiens_hsa040120.40765373
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38436328
96Huntingtons disease_Homo sapiens_hsa050160.38274443
97TGF-beta signaling pathway_Homo sapiens_hsa043500.36967518
98Insulin signaling pathway_Homo sapiens_hsa049100.36778576
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35865272
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35310339

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