C1ORF216

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)8.99323402
2synaptic vesicle docking involved in exocytosis (GO:0016081)7.89336445
3synaptic vesicle exocytosis (GO:0016079)7.42469832
4glutamate secretion (GO:0014047)7.34253523
5regulation of short-term neuronal synaptic plasticity (GO:0048172)7.24256900
6regulation of synaptic vesicle exocytosis (GO:2000300)6.75586709
7regulation of synaptic vesicle transport (GO:1902803)6.00717976
8neurotransmitter secretion (GO:0007269)5.60146821
9membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.25124594
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.22420789
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.17093916
12negative regulation of synaptic transmission, GABAergic (GO:0032229)5.03612261
13neuronal action potential propagation (GO:0019227)4.96652991
14regulation of synapse structural plasticity (GO:0051823)4.80299780
15regulation of neuronal synaptic plasticity (GO:0048168)4.67495139
16synaptic transmission, glutamatergic (GO:0035249)4.57418088
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.55015524
18cellular potassium ion homeostasis (GO:0030007)4.44224100
19gamma-aminobutyric acid transport (GO:0015812)4.43595408
20neurotransmitter transport (GO:0006836)4.36163261
21locomotory exploration behavior (GO:0035641)4.35006346
22regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.21584368
23regulation of neurotransmitter secretion (GO:0046928)4.20817616
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.17969853
25protein localization to synapse (GO:0035418)4.17300226
26regulation of vesicle fusion (GO:0031338)4.14031443
27neuron-neuron synaptic transmission (GO:0007270)4.09318735
28synaptic vesicle endocytosis (GO:0048488)4.06628382
29regulation of neurotransmitter levels (GO:0001505)4.06205899
30G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.05130014
31establishment of mitochondrion localization (GO:0051654)4.01684891
32vocalization behavior (GO:0071625)3.98141319
33exploration behavior (GO:0035640)3.97379422
34positive regulation of neurotransmitter secretion (GO:0001956)3.95905167
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.95867125
36amino acid import (GO:0043090)3.95824507
37L-amino acid import (GO:0043092)3.94332089
38sodium ion export (GO:0071436)3.94100581
39proline transport (GO:0015824)3.93980717
40neurotransmitter-gated ion channel clustering (GO:0072578)3.93597285
41neuron cell-cell adhesion (GO:0007158)3.90326991
42layer formation in cerebral cortex (GO:0021819)3.80886385
43regulation of voltage-gated calcium channel activity (GO:1901385)3.79435817
44regulation of neurotransmitter transport (GO:0051588)3.76705135
45positive regulation of neurotransmitter transport (GO:0051590)3.69264894
46regulation of glutamate receptor signaling pathway (GO:1900449)3.68910101
47regulation of excitatory postsynaptic membrane potential (GO:0060079)3.67900493
48regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.67205698
49positive regulation of synapse maturation (GO:0090129)3.64404880
50postsynaptic membrane organization (GO:0001941)3.62170023
51regulation of synaptic plasticity (GO:0048167)3.61317195
52vesicle docking involved in exocytosis (GO:0006904)3.58979261
53positive regulation of membrane potential (GO:0045838)3.57509927
54gamma-aminobutyric acid signaling pathway (GO:0007214)3.56001582
55glutamate receptor signaling pathway (GO:0007215)3.55439933
56positive regulation of dendritic spine development (GO:0060999)3.52701555
57neuronal ion channel clustering (GO:0045161)3.49292865
58acidic amino acid transport (GO:0015800)3.48153556
59dendritic spine morphogenesis (GO:0060997)3.47628332
60glycosphingolipid biosynthetic process (GO:0006688)3.41388337
61establishment of synaptic vesicle localization (GO:0097480)3.39568343
62synaptic vesicle transport (GO:0048489)3.39568343
63pyrimidine nucleobase catabolic process (GO:0006208)3.39329757
64regulation of postsynaptic membrane potential (GO:0060078)3.35128741
65membrane depolarization during action potential (GO:0086010)3.33488194
66vesicle docking (GO:0048278)3.30132055
67negative regulation of dendrite morphogenesis (GO:0050774)3.28772470
68neuromuscular synaptic transmission (GO:0007274)3.24534904
69membrane depolarization (GO:0051899)3.23240668
70neuromuscular process controlling balance (GO:0050885)3.23149904
71positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.22792533
72synaptic transmission (GO:0007268)3.21898946
73positive regulation of dendritic spine morphogenesis (GO:0061003)3.21504260
74cerebellar granule cell differentiation (GO:0021707)3.20391286
75neuromuscular process controlling posture (GO:0050884)3.14720117
76regulation of synaptic transmission (GO:0050804)3.10668222
77regulation of dendritic spine morphogenesis (GO:0061001)3.08664562
78L-glutamate transport (GO:0015813)3.03356387
79cerebellar Purkinje cell differentiation (GO:0021702)3.02721957
80cell migration in hindbrain (GO:0021535)3.01271607
81negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.99589536
82ATP hydrolysis coupled proton transport (GO:0015991)2.99212876
83energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.99212876
84mitochondrion transport along microtubule (GO:0047497)2.97915260
85establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.97915260
86cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.96574817
87regulation of exocytosis (GO:0017157)2.94781826
88positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.93968532
89detection of calcium ion (GO:0005513)2.92941934
90regulation of dendritic spine development (GO:0060998)2.92398381
91dicarboxylic acid transport (GO:0006835)2.92136994
92long-term memory (GO:0007616)2.91910254
93long-term synaptic potentiation (GO:0060291)2.91525211
94dendritic spine organization (GO:0097061)2.91190649
95neurotransmitter uptake (GO:0001504)2.89152043
96signal release (GO:0023061)2.89018499
97regulation of synaptic transmission, glutamatergic (GO:0051966)2.88534441
98nucleobase catabolic process (GO:0046113)2.87726712
99regulation of synapse maturation (GO:0090128)2.85975486
100positive regulation of synaptic transmission (GO:0050806)2.82582512

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.94893687
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.71534895
3CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.93523941
4REST_21632747_ChIP-Seq_MESCs_Mouse3.51450671
5RARB_27405468_Chip-Seq_BRAIN_Mouse3.33928003
6REST_18959480_ChIP-ChIP_MESCs_Mouse3.25793945
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09517688
8DROSHA_22980978_ChIP-Seq_HELA_Human2.82316460
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.81720573
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.78948309
11SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.71607481
12IKZF1_21737484_ChIP-ChIP_HCT116_Human2.68130505
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67469649
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.62226584
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.61812239
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.56462776
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.43787955
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.39897689
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.39634179
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.38126128
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.35872461
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.35872461
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34503591
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.31002481
25EZH2_27304074_Chip-Seq_ESCs_Mouse2.29754154
26GBX2_23144817_ChIP-Seq_PC3_Human2.26295761
27CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.25498600
28DNAJC2_21179169_ChIP-ChIP_NT2_Human2.15405276
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.13626053
30EED_16625203_ChIP-ChIP_MESCs_Mouse2.12178127
31RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.99015529
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.93589814
33RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.85785436
34ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.75002767
35TET1_21490601_ChIP-Seq_MESCs_Mouse1.74927316
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68697089
37SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.66267443
38SRY_22984422_ChIP-ChIP_TESTIS_Rat1.59688202
39SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.53781937
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.53398478
41EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.52538287
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.45087410
43PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.34617450
44CTCF_27219007_Chip-Seq_Bcells_Human1.34203513
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32892545
46LXR_22292898_ChIP-Seq_THP-1_Human1.28718830
47SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.28166890
48* KDM2B_26808549_Chip-Seq_K562_Human1.25490040
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25355953
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.25348436
51TET1_21451524_ChIP-Seq_MESCs_Mouse1.23655914
52OCT4_19829295_ChIP-Seq_ESCs_Human1.21461449
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21333219
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20787565
55OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13066723
56GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11493313
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.11378687
58P68_20966046_ChIP-Seq_HELA_Human1.07736127
59SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07451808
60SMC4_20622854_ChIP-Seq_HELA_Human1.01943956
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.01868972
62SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01688474
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99537356
64THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95768678
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95208564
66CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93699526
67KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91649827
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91631963
69CTCF_20526341_ChIP-Seq_ESCs_Human0.90090805
70SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.89086814
71TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.87811184
72RNF2_27304074_Chip-Seq_NSC_Mouse0.84374770
73CBX2_27304074_Chip-Seq_ESCs_Mouse0.83680996
74NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.82786638
75ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82681615
76* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.80906579
77BCL6_27268052_Chip-Seq_Bcells_Human0.80051463
78PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.79984724
79NR3C1_23031785_ChIP-Seq_PC12_Mouse0.79712442
80RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.79631305
81* SA1_27219007_Chip-Seq_Bcells_Human0.78328026
82TP53_23651856_ChIP-Seq_MEFs_Mouse0.78193115
83CTCF_18555785_ChIP-Seq_MESCs_Mouse0.78103419
84SA1_27219007_Chip-Seq_ERYTHROID_Human0.77462852
85AR_19668381_ChIP-Seq_PC3_Human0.76878605
86CTBP2_25329375_ChIP-Seq_LNCAP_Human0.76818261
87FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.76586644
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.76270231
89PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.75170907
90SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.75094182
91DPY_21335234_ChIP-Seq_ESCs_Mouse0.75016648
92ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.74260463
93RAD21_21589869_ChIP-Seq_MESCs_Mouse0.73581550
94KLF4_19829295_ChIP-Seq_ESCs_Human0.73341690
95AR_21572438_ChIP-Seq_LNCaP_Human0.73040506
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.72713344
97MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.71712992
98* KDM2B_26808549_Chip-Seq_DND41_Human0.71345808
99TP53_22127205_ChIP-Seq_IMR90_Human0.70663908
100MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.69041082

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.54972182
2MP0003880_abnormal_central_pattern4.78329627
3MP0004270_analgesia4.12437341
4MP0003635_abnormal_synaptic_transmissio4.06726178
5MP0002064_seizures3.58315755
6MP0005423_abnormal_somatic_nervous3.40639769
7MP0001968_abnormal_touch/_nociception3.39022762
8MP0002063_abnormal_learning/memory/cond3.29293673
9MP0009745_abnormal_behavioral_response3.29107715
10MP0009046_muscle_twitch3.27672367
11MP0002272_abnormal_nervous_system3.01544891
12MP0002572_abnormal_emotion/affect_behav2.73045659
13MP0002734_abnormal_mechanical_nocicepti2.68181325
14MP0001486_abnormal_startle_reflex2.64832067
15MP0002736_abnormal_nociception_after2.60674826
16MP0001501_abnormal_sleep_pattern2.42754502
17MP0002735_abnormal_chemical_nociception2.40150924
18MP0003329_amyloid_beta_deposits2.38004704
19MP0008569_lethality_at_weaning2.22487742
20MP0002733_abnormal_thermal_nociception2.10648335
21MP0001970_abnormal_pain_threshold2.09321766
22MP0004811_abnormal_neuron_physiology1.90303089
23MP0003787_abnormal_imprinting1.88310253
24MP0006276_abnormal_autonomic_nervous1.86471976
25MP0005646_abnormal_pituitary_gland1.81057692
26MP0001905_abnormal_dopamine_level1.77810950
27MP0002067_abnormal_sensory_capabilities1.74984638
28MP0003879_abnormal_hair_cell1.72542181
29MP0002557_abnormal_social/conspecific_i1.69455179
30MP0001440_abnormal_grooming_behavior1.53729377
31MP0003633_abnormal_nervous_system1.50514324
32MP0000778_abnormal_nervous_system1.49070911
33MP0002066_abnormal_motor_capabilities/c1.48664748
34MP0004924_abnormal_behavior1.47594092
35MP0005386_behavior/neurological_phenoty1.47594092
36MP0000920_abnormal_myelination1.47535372
37MP0004147_increased_porphyrin_level1.47464869
38MP0001502_abnormal_circadian_rhythm1.46006488
39MP0002882_abnormal_neuron_morphology1.41770448
40MP0001984_abnormal_olfaction1.40047003
41MP0000604_amyloidosis1.35334635
42MP0002184_abnormal_innervation1.29590739
43MP0003631_nervous_system_phenotype1.29205851
44MP0010386_abnormal_urinary_bladder1.29184127
45MP0001986_abnormal_taste_sensitivity1.28980165
46MP0000955_abnormal_spinal_cord1.27692617
47MP0003690_abnormal_glial_cell1.19856810
48MP0001177_atelectasis1.18979856
49MP0004885_abnormal_endolymph1.16813543
50MP0003075_altered_response_to1.16672598
51MP0002229_neurodegeneration1.16671945
52MP0003172_abnormal_lysosome_physiology1.16082404
53MP0002822_catalepsy1.13671080
54MP0003634_abnormal_glial_cell1.08715148
55MP0001529_abnormal_vocalization1.08389166
56MP0005645_abnormal_hypothalamus_physiol1.04622795
57MP0000751_myopathy1.02732604
58MP0008874_decreased_physiological_sensi1.01857612
59MP0001188_hyperpigmentation1.00913602
60MP0005499_abnormal_olfactory_system1.00283240
61MP0005394_taste/olfaction_phenotype1.00283240
62MP0002152_abnormal_brain_morphology0.97485682
63MP0005167_abnormal_blood-brain_barrier0.96825513
64MP0005551_abnormal_eye_electrophysiolog0.94082419
65MP0001348_abnormal_lacrimal_gland0.92505676
66MP0004142_abnormal_muscle_tone0.91513843
67MP0005535_abnormal_body_temperature0.89371609
68MP0002638_abnormal_pupillary_reflex0.88706617
69MP0005623_abnormal_meninges_morphology0.85944429
70MP0001963_abnormal_hearing_physiology0.85144375
71MP0005171_absent_coat_pigmentation0.84678043
72MP0004742_abnormal_vestibular_system0.82878377
73MP0003632_abnormal_nervous_system0.81404186
74MP0005058_abnormal_lysosome_morphology0.77153085
75MP0002069_abnormal_eating/drinking_beha0.76913811
76MP0000013_abnormal_adipose_tissue0.76880162
77MP0008872_abnormal_physiological_respon0.74076167
78MP0003122_maternal_imprinting0.72507565
79MP0009780_abnormal_chondrocyte_physiolo0.70781926
80MP0002752_abnormal_somatic_nervous0.69384536
81MP0006035_abnormal_mitochondrial_morpho0.68298404
82MP0009278_abnormal_bone_marrow0.65399346
83MP0006036_abnormal_mitochondrial_physio0.62007764
84MP0003123_paternal_imprinting0.61640252
85MP0002102_abnormal_ear_morphology0.60400294
86MP0003137_abnormal_impulse_conducting0.55807677
87MP0002332_abnormal_exercise_endurance0.54857704
88MP0002909_abnormal_adrenal_gland0.54713905
89MP0002090_abnormal_vision0.53403018
90MP0001542_abnormal_bone_strength0.52827708
91MP0010769_abnormal_survival0.51635506
92MP0000747_muscle_weakness0.50946765
93MP0005253_abnormal_eye_physiology0.50875532
94MP0000569_abnormal_digit_pigmentation0.50409618
95MP0004130_abnormal_muscle_cell0.50035671
96MP0004043_abnormal_pH_regulation0.49915133
97MP0001943_abnormal_respiration0.49697504
98MP0002653_abnormal_ependyma_morphology0.49645358
99MP0010768_mortality/aging0.49143796
100MP0004085_abnormal_heartbeat0.47904479

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.84115177
2Focal motor seizures (HP:0011153)6.67370427
3Focal seizures (HP:0007359)5.64143832
4Epileptic encephalopathy (HP:0200134)4.71779760
5Supranuclear gaze palsy (HP:0000605)4.66648276
6Atonic seizures (HP:0010819)4.52106050
7Ankle clonus (HP:0011448)4.51634479
8Febrile seizures (HP:0002373)4.50853040
9Visual hallucinations (HP:0002367)4.44012408
10Action tremor (HP:0002345)4.30735798
11Mutism (HP:0002300)4.26163922
12Spastic gait (HP:0002064)3.80998041
13Diplopia (HP:0000651)3.79440398
14Abnormality of binocular vision (HP:0011514)3.79440398
15Generalized tonic-clonic seizures (HP:0002069)3.75318660
16Neurofibrillary tangles (HP:0002185)3.69388157
17Delusions (HP:0000746)3.55354637
18Dialeptic seizures (HP:0011146)3.51954220
19Cerebral hypomyelination (HP:0006808)3.39812593
20Truncal ataxia (HP:0002078)3.36790770
21Abnormal eating behavior (HP:0100738)3.25625845
22Absence seizures (HP:0002121)3.25118836
23Cerebral inclusion bodies (HP:0100314)3.23625422
24Tetraplegia (HP:0002445)3.20282424
25Limb dystonia (HP:0002451)3.19110882
26Progressive cerebellar ataxia (HP:0002073)3.18374439
27Poor eye contact (HP:0000817)3.03344662
28Urinary urgency (HP:0000012)3.03033745
29Papilledema (HP:0001085)3.02384421
30Urinary bladder sphincter dysfunction (HP:0002839)3.01356368
31Torticollis (HP:0000473)2.96372128
32Insomnia (HP:0100785)2.91462021
33Lower limb muscle weakness (HP:0007340)2.91212058
34Focal dystonia (HP:0004373)2.91011256
35Intention tremor (HP:0002080)2.86417524
36Dysmetria (HP:0001310)2.85255943
37Postural instability (HP:0002172)2.83116133
38Depression (HP:0000716)2.82308408
39Status epilepticus (HP:0002133)2.82047950
40Hemiparesis (HP:0001269)2.80824265
41Neuronal loss in central nervous system (HP:0002529)2.80770710
42Annular pancreas (HP:0001734)2.80622283
43Peripheral hypomyelination (HP:0007182)2.79604012
44Clonus (HP:0002169)2.77444744
45Amyotrophic lateral sclerosis (HP:0007354)2.73920463
46Absent speech (HP:0001344)2.69320508
47Epileptiform EEG discharges (HP:0011182)2.68534312
48Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.65103067
49Craniofacial dystonia (HP:0012179)2.64764950
50Spastic tetraparesis (HP:0001285)2.64106485
51Impaired vibration sensation in the lower limbs (HP:0002166)2.61826159
52Diminished motivation (HP:0000745)2.60479644
53Apathy (HP:0000741)2.57820330
54Bradykinesia (HP:0002067)2.56338993
55Polyphagia (HP:0002591)2.49715666
56EEG with generalized epileptiform discharges (HP:0011198)2.44607225
57Dysdiadochokinesis (HP:0002075)2.39569817
58Failure to thrive in infancy (HP:0001531)2.36009531
59Progressive microcephaly (HP:0000253)2.35715968
60Hypsarrhythmia (HP:0002521)2.33177917
61Abnormality of the lower motor neuron (HP:0002366)2.32301420
62Akinesia (HP:0002304)2.32145605
63Spastic tetraplegia (HP:0002510)2.25860538
64Amblyopia (HP:0000646)2.23819344
65Hemiplegia (HP:0002301)2.20417533
66Unsteady gait (HP:0002317)2.20250140
67CNS hypomyelination (HP:0003429)2.20070220
68Impaired social interactions (HP:0000735)2.18307185
69Abnormal social behavior (HP:0012433)2.18307185
70Drooling (HP:0002307)2.17831467
71Scanning speech (HP:0002168)2.13317584
72Impaired smooth pursuit (HP:0007772)2.12993709
73Inability to walk (HP:0002540)2.12272246
74Anxiety (HP:0000739)2.08209201
75Ulnar claw (HP:0001178)2.08074863
76Abnormality of the corticospinal tract (HP:0002492)2.08021734
77Broad-based gait (HP:0002136)2.06670459
78Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.03664811
79Emotional lability (HP:0000712)2.02028896
80Excessive salivation (HP:0003781)2.01231171
81Rigidity (HP:0002063)2.00081773
82Rapidly progressive (HP:0003678)1.99395237
83Progressive inability to walk (HP:0002505)1.97925486
84Impaired vibratory sensation (HP:0002495)1.94010595
85Prolonged QT interval (HP:0001657)1.92500571
86Choreoathetosis (HP:0001266)1.89531765
87Abnormality of ocular smooth pursuit (HP:0000617)1.87501754
88Ragged-red muscle fibers (HP:0003200)1.86880531
89Paraplegia (HP:0010550)1.85866824
90Hand muscle atrophy (HP:0009130)1.83804520
91Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83686017
92Limb ataxia (HP:0002070)1.82347006
93Abnormality of liposaccharide metabolism (HP:0010968)1.82288316
94Abnormality of glycosphingolipid metabolism (HP:0004343)1.82288316
95Abnormality of glycolipid metabolism (HP:0010969)1.82288316
96Abnormal EKG (HP:0003115)1.81594310
97Hyperacusis (HP:0010780)1.76531241
98Stereotypic behavior (HP:0000733)1.76004294
99Gaze-evoked nystagmus (HP:0000640)1.75961600
100Atrophy/Degeneration involving motor neurons (HP:0007373)1.75933845

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.80057047
2MARK14.14159057
3DAPK23.73465623
4PAK63.69933353
5NTRK32.96476278
6MINK12.15184806
7NTRK12.12410118
8PLK22.05301111
9CAMKK12.04376989
10ARAF1.97846643
11PRKD31.86548369
12DAPK11.85235525
13MAP3K111.83948016
14NTRK21.78534505
15SIK21.76675088
16MAP2K71.74659304
17CDK191.73431062
18PHKG21.65412316
19PHKG11.65412316
20GRK51.64620995
21MAPK131.64594448
22PINK11.63631532
23UHMK11.60780920
24LIMK11.57769655
25MAP3K41.56385512
26MAP3K91.48138327
27CAMKK21.45088218
28CDK51.44128898
29MAP4K21.36601028
30CSNK1G21.36208884
31PIM21.34659275
32RIPK41.32299856
33PRKCG1.31300274
34CCNB11.29900421
35MAP2K41.25044754
36CDK141.23982792
37CDK151.22172145
38CDK181.20173285
39CDK11A1.15695434
40CSNK1G31.12429058
41CASK1.10799764
42CSNK1A1L1.09908308
43SCYL21.07019485
44CAMK11.06634828
45CAMK2B1.00549110
46TESK10.97631596
47CAMK2A0.90440959
48LATS20.86661289
49PRKCH0.86015925
50MAP3K60.80911724
51BCKDK0.80796770
52MAPK120.80196798
53DYRK1A0.79541973
54DAPK30.79415794
55ALK0.78372180
56CAMK2G0.73308570
57BRAF0.71379172
58STK160.68217271
59FES0.66430676
60MARK20.65903850
61BMPR20.65704445
62BCR0.65152393
63TESK20.63470924
64RAF10.63091336
65MAP2K60.63054950
66STK380.61930737
67CSNK1G10.61784863
68ABL20.61477542
69PKN10.61406835
70KSR20.60230909
71PAK30.59494375
72STK110.57728643
73PRKCE0.57659492
74OXSR10.56338000
75DYRK20.53728418
76MAP3K50.53695727
77PRPF4B0.51839670
78RIPK10.50814345
79CAMK40.48050168
80PDK10.46016816
81SGK4940.45162355
82SGK2230.45162355
83TAOK20.44988190
84PDPK10.42949880
85MAP3K120.42490257
86GRK70.42443782
87MAPK100.42323105
88TYRO30.42081590
89IRAK30.40470234
90PRKCZ0.40108004
91MAPKAPK50.39742022
92ADRBK20.38699042
93CAMK2D0.38257924
94RPS6KA30.38124962
95PRKCA0.34069742
96AKT30.34048986
97MAPK40.31794480
98ADRBK10.31509330
99CSNK1D0.29930355
100PRKCI0.29327070

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.89908225
2Nicotine addiction_Homo sapiens_hsa050334.33126167
3GABAergic synapse_Homo sapiens_hsa047273.11512320
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.82228530
5Morphine addiction_Homo sapiens_hsa050322.73820529
6Circadian entrainment_Homo sapiens_hsa047132.66884012
7Amphetamine addiction_Homo sapiens_hsa050312.50392232
8Long-term potentiation_Homo sapiens_hsa047202.48253051
9Glutamatergic synapse_Homo sapiens_hsa047242.38060018
10Insulin secretion_Homo sapiens_hsa049112.34600753
11Dopaminergic synapse_Homo sapiens_hsa047282.18253755
12Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.08859058
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.08758318
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.07868005
15Collecting duct acid secretion_Homo sapiens_hsa049661.93742336
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.89650511
17Salivary secretion_Homo sapiens_hsa049701.88984145
18Cocaine addiction_Homo sapiens_hsa050301.87388310
19Gastric acid secretion_Homo sapiens_hsa049711.86193189
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.84481400
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76405397
22Cholinergic synapse_Homo sapiens_hsa047251.74743964
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68296846
24Oxytocin signaling pathway_Homo sapiens_hsa049211.57828230
25Calcium signaling pathway_Homo sapiens_hsa040201.52909357
26Vibrio cholerae infection_Homo sapiens_hsa051101.40908717
27Taste transduction_Homo sapiens_hsa047421.35790053
28Long-term depression_Homo sapiens_hsa047301.34362407
29Olfactory transduction_Homo sapiens_hsa047401.28094815
30Phototransduction_Homo sapiens_hsa047441.27100459
31cAMP signaling pathway_Homo sapiens_hsa040241.22740961
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.21398281
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21227285
34Renin secretion_Homo sapiens_hsa049241.12033016
35GnRH signaling pathway_Homo sapiens_hsa049121.11057199
36Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10085056
37Serotonergic synapse_Homo sapiens_hsa047261.02455015
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01363730
39Glioma_Homo sapiens_hsa052140.96438176
40Estrogen signaling pathway_Homo sapiens_hsa049150.95452787
41Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93085216
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91849658
43Cardiac muscle contraction_Homo sapiens_hsa042600.90862210
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89103429
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85790853
46cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85297237
47Gap junction_Homo sapiens_hsa045400.82484983
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82048734
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81837884
50ErbB signaling pathway_Homo sapiens_hsa040120.78835613
51Neurotrophin signaling pathway_Homo sapiens_hsa047220.76788149
52Oocyte meiosis_Homo sapiens_hsa041140.74899096
53Vitamin B6 metabolism_Homo sapiens_hsa007500.71958021
54VEGF signaling pathway_Homo sapiens_hsa043700.69141570
55Rheumatoid arthritis_Homo sapiens_hsa053230.66196344
56Axon guidance_Homo sapiens_hsa043600.65111696
57Type II diabetes mellitus_Homo sapiens_hsa049300.64941736
58Melanogenesis_Homo sapiens_hsa049160.62847934
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.61941090
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.61739950
61Ras signaling pathway_Homo sapiens_hsa040140.60225045
62MAPK signaling pathway_Homo sapiens_hsa040100.60144642
63Endocytosis_Homo sapiens_hsa041440.56845397
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56654919
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.56282749
66Alzheimers disease_Homo sapiens_hsa050100.55461431
67Oxidative phosphorylation_Homo sapiens_hsa001900.55298334
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54727657
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53965838
70Lysosome_Homo sapiens_hsa041420.52962543
71mTOR signaling pathway_Homo sapiens_hsa041500.49996488
72Thyroid hormone synthesis_Homo sapiens_hsa049180.48884591
73Pancreatic secretion_Homo sapiens_hsa049720.47449416
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.46981100
75Prion diseases_Homo sapiens_hsa050200.44935156
76Inositol phosphate metabolism_Homo sapiens_hsa005620.44803720
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44396091
78Regulation of autophagy_Homo sapiens_hsa041400.41699002
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41421300
80Dilated cardiomyopathy_Homo sapiens_hsa054140.41420083
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40161039
82Phagosome_Homo sapiens_hsa041450.39490602
83Rap1 signaling pathway_Homo sapiens_hsa040150.39477134
84Glucagon signaling pathway_Homo sapiens_hsa049220.39164084
85Parkinsons disease_Homo sapiens_hsa050120.33765982
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.32488826
87Salmonella infection_Homo sapiens_hsa051320.32378360
88Butanoate metabolism_Homo sapiens_hsa006500.31815892
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29279419
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28437168
91AMPK signaling pathway_Homo sapiens_hsa041520.27766612
92Shigellosis_Homo sapiens_hsa051310.26096005
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23791370
94Choline metabolism in cancer_Homo sapiens_hsa052310.23592396
95Sulfur relay system_Homo sapiens_hsa041220.21053208
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17467598
97Alcoholism_Homo sapiens_hsa050340.17106643
98Ether lipid metabolism_Homo sapiens_hsa005650.15526159
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.14639458
100Ovarian steroidogenesis_Homo sapiens_hsa049130.14055704

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