C1ORF189

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1left/right pattern formation (GO:0060972)8.87520455
2regulation of cilium movement (GO:0003352)8.62356621
3primary alcohol catabolic process (GO:0034310)7.10883084
4left/right axis specification (GO:0070986)6.77119939
5ventricular system development (GO:0021591)6.74754659
6vitamin transmembrane transport (GO:0035461)6.60674318
7microtubule bundle formation (GO:0001578)6.58070569
8intraciliary transport (GO:0042073)6.45480880
9ethanol metabolic process (GO:0006067)6.15525888
10diterpenoid biosynthetic process (GO:0016102)6.05041678
11cilium organization (GO:0044782)6.01539802
12centriole assembly (GO:0098534)5.91073185
13cilium assembly (GO:0042384)5.87704713
14one-carbon compound transport (GO:0019755)5.47465977
15sperm capacitation (GO:0048240)5.43657137
16pyrimidine-containing compound transmembrane transport (GO:0072531)5.38195398
17regulation of microtubule-based movement (GO:0060632)5.18101050
18tolerance induction (GO:0002507)5.16155317
19response to xenobiotic stimulus (GO:0009410)5.15845073
20microtubule depolymerization (GO:0007019)5.13337764
21glomerular epithelial cell development (GO:0072310)4.97954929
22lung epithelium development (GO:0060428)4.94665530
23negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.84756759
24negative regulation of B cell mediated immunity (GO:0002713)4.72218515
25negative regulation of immunoglobulin mediated immune response (GO:0002890)4.72218515
26protein localization to cilium (GO:0061512)4.70747003
27microtubule-based movement (GO:0007018)4.69328656
28negative regulation of T cell differentiation in thymus (GO:0033085)4.65808934
29establishment of apical/basal cell polarity (GO:0035089)4.64733206
30cellular component assembly involved in morphogenesis (GO:0010927)4.62604587
31ethanol oxidation (GO:0006069)4.59413601
32microtubule polymerization or depolymerization (GO:0031109)4.58701377
33regulation of interleukin-5 production (GO:0032674)4.56824924
34regulation of germinal center formation (GO:0002634)4.31893020
35negative regulation of humoral immune response (GO:0002921)4.31543273
36regulation of interleukin-13 production (GO:0032656)4.29155328
37cell projection assembly (GO:0030031)4.25867549
38positive regulation of tolerance induction (GO:0002645)4.22842149
39cilium morphogenesis (GO:0060271)4.17637510
40terpenoid biosynthetic process (GO:0016114)4.14236594
41establishment or maintenance of monopolar cell polarity (GO:0061339)4.12799116
42establishment of monopolar cell polarity (GO:0061162)4.12799116
43negative regulation of inclusion body assembly (GO:0090084)3.97169795
44sperm motility (GO:0030317)3.96657904
45retinoic acid metabolic process (GO:0042573)3.95824555
46cytoplasmic microtubule organization (GO:0031122)3.90484489
47nucleoside diphosphate phosphorylation (GO:0006165)3.83708375
48exogenous drug catabolic process (GO:0042738)3.72675274
49centriole replication (GO:0007099)3.64020689
50establishment of planar polarity (GO:0001736)3.32893722
51establishment of tissue polarity (GO:0007164)3.32893722
52primary alcohol metabolic process (GO:0034308)3.21902717
53regulation of tolerance induction (GO:0002643)3.18148473
54lateral ventricle development (GO:0021670)3.15850976
55retinol metabolic process (GO:0042572)3.06269662
56axonemal dynein complex assembly (GO:0070286)22.6711818
57O-glycan processing (GO:0016266)2.98782510
58regulation of microtubule depolymerization (GO:0031114)2.96128254
59glutathione derivative metabolic process (GO:1901685)2.95844782
60glutathione derivative biosynthetic process (GO:1901687)2.95844782
61positive regulation of smoothened signaling pathway (GO:0045880)2.94127273
62drug catabolic process (GO:0042737)2.91573331
63regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.91163613
64hydrogen peroxide biosynthetic process (GO:0050665)2.90647047
65aldehyde catabolic process (GO:0046185)2.89966144
66multicellular organismal water homeostasis (GO:0050891)2.88472470
67pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.87958651
68determination of left/right symmetry (GO:0007368)2.87543991
69microtubule-based process (GO:0007017)2.81704472
70phosphatidylethanolamine biosynthetic process (GO:0006646)2.80404840
71determination of bilateral symmetry (GO:0009855)2.76272398
72phosphatidylcholine biosynthetic process (GO:0006656)2.75137041
73phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.74841340
74reactive oxygen species biosynthetic process (GO:1903409)2.71930062
75excretion (GO:0007588)2.70474425
76specification of symmetry (GO:0009799)2.70170401
77hydrogen peroxide catabolic process (GO:0042744)2.64542353
78organelle assembly (GO:0070925)2.64332829
79smoothened signaling pathway (GO:0007224)2.63351282
80carnitine metabolic process (GO:0009437)2.61980696
81oligosaccharide biosynthetic process (GO:0009312)2.60969168
82phosphatidylethanolamine metabolic process (GO:0046337)2.56622968
83base-excision repair, AP site formation (GO:0006285)2.56272280
84regulation of autophagic vacuole assembly (GO:2000785)2.54559015
85regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.53398969
86regulation of response to osmotic stress (GO:0047484)2.53309483
87lateral sprouting from an epithelium (GO:0060601)2.51826851
88progesterone metabolic process (GO:0042448)2.50676238
89protein polyglutamylation (GO:0018095)2.50202635
90pyrimidine nucleotide catabolic process (GO:0006244)2.47214931
91polyol transport (GO:0015791)2.47189597
92regulation of inclusion body assembly (GO:0090083)2.46616835
93water homeostasis (GO:0030104)2.45057902
94heart looping (GO:0001947)2.44934838
95cilium or flagellum-dependent cell motility (GO:0001539)17.9699743
96cilium movement (GO:0003341)15.6966568
97motile cilium assembly (GO:0044458)15.0046900
98epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)14.9259593
99epithelial cilium movement (GO:0003351)13.9143300
100axoneme assembly (GO:0035082)10.4491087

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.45434029
2FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.36092270
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.35322925
4DROSHA_22980978_ChIP-Seq_HELA_Human3.31080839
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.14673893
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.35751724
7SMC4_20622854_ChIP-Seq_HELA_Human2.14100225
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.08357034
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.06644492
10RUNX1_27514584_Chip-Seq_MCF-7_Human1.93216826
11STAT1_20625510_ChIP-Seq_HELA_Human1.89693922
12SOX2_27498859_Chip-Seq_STOMACH_Mouse1.78950584
13FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.78731259
14AHR_22903824_ChIP-Seq_MCF-7_Human1.73457460
15PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.67376121
16TDRD3_21172665_ChIP-Seq_MCF-7_Human1.66959818
17CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.65327942
18KLF5_25053715_ChIP-Seq_YYC3_Human1.65036100
19* ELF1_20517297_ChIP-Seq_JURKAT_Human1.64786186
20TP63_22573176_ChIP-Seq_HFKS_Human1.64685161
21TP63_23658742_ChIP-Seq_EP156T_Human1.64387167
22P63_26484246_Chip-Seq_KERATINOCYTES_Human1.63402626
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61740698
24ARNT_22903824_ChIP-Seq_MCF-7_Human1.58158999
25SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.56542566
26ETV1_20927104_ChIP-Seq_GIST48_Human1.54241298
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.54133285
28VDR_22108803_ChIP-Seq_LS180_Human1.53249734
29AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.51074963
30RAD21_21589869_ChIP-Seq_MESCs_Mouse1.49854269
31P68_20966046_ChIP-Seq_HELA_Human1.49473625
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.48455713
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.46531928
34* ESR1_20079471_ChIP-ChIP_T-47D_Human1.45781885
35FOXM1_26456572_ChIP-Seq_MCF-7_Human1.45730693
36ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42458493
37PHF8_20622853_ChIP-Seq_HELA_Human1.40503672
38HNFA_21074721_ChIP-Seq_CACO-2_Human1.39647840
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38374895
40CTCF_20526341_ChIP-Seq_ESCs_Human1.38056121
41CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.37896404
42NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37237452
43PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.35262198
44FOXA1_25552417_ChIP-Seq_VCAP_Human1.33665302
45SOX9_24532713_ChIP-Seq_HFSC_Mouse1.33033413
46TP53_18474530_ChIP-ChIP_U2OS_Human1.32970157
47* YY1_22570637_ChIP-Seq_MALME-3M_Human1.32137859
48PHF8_20622854_ChIP-Seq_HELA_Human1.31148433
49RBPJ_21746931_ChIP-Seq_IB4_Human1.29350645
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29214267
51GATA1_19941826_ChIP-Seq_K562_Human1.28008801
52* CTCF_27219007_Chip-Seq_Bcells_Human1.27748248
53ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.25004576
54CBX2_22325352_ChIP-Seq_293T-Rex_Human1.24673118
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24207878
56GATA6_21074721_ChIP-Seq_CACO-2_Human1.22714011
57SOX2_20726797_ChIP-Seq_SW620_Human1.21184568
58* SMRT_27268052_Chip-Seq_Bcells_Human1.20518206
59GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.18229704
60CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17250459
61TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15299401
62CREB1_26743006_Chip-Seq_LNCaP_Human1.15102697
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14726430
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14689583
65SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13677800
66SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.13613537
67FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.13509434
68E2F1_20622854_ChIP-Seq_HELA_Human1.12817619
69GATA4_25053715_ChIP-Seq_YYC3_Human1.10963201
70VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.10795565
71* P300_27268052_Chip-Seq_Bcells_Human1.10094109
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08812645
73NFYA_21822215_ChIP-Seq_K562_Human1.07353830
74EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.07045551
75CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05244429
76* CEBPB_22108803_ChIP-Seq_LS180_Human1.05240453
77GATA3_24758297_ChIP-Seq_MCF-7_Human1.05070573
78ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04786669
79NFYB_21822215_ChIP-Seq_K562_Human1.04400308
80SOX2_21211035_ChIP-Seq_LN229_Human1.03814433
81RACK7_27058665_Chip-Seq_MCF-7_Human1.02218814
82OCT4_20526341_ChIP-Seq_ESCs_Human0.97995248
83LXR_22292898_ChIP-Seq_THP-1_Human0.97653928
84FLI1_21867929_ChIP-Seq_CD8_Mouse0.97386194
85TBL1_22424771_ChIP-Seq_293T_Human0.97248346
86* BCOR_27268052_Chip-Seq_Bcells_Human0.96551696
87TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95659841
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95570293
89* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.94614127
90PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94425739
91P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.94362743
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92850644
93RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92539465
94FOXO3_23340844_ChIP-Seq_DLD1_Human0.92331427
95FOXA2_19822575_ChIP-Seq_HepG2_Human0.92310508
96CDX2_20551321_ChIP-Seq_CACO-2_Human0.92256357
97WDR5_24793694_ChIP-Seq_LNCAP_Human0.90945283
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89318232
99GATA2_19941826_ChIP-Seq_K562_Human0.89073188
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88562696

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok6.99802112
2MP0002653_abnormal_ependyma_morphology6.38336670
3MP0002132_abnormal_respiratory_system5.87702518
4MP0004043_abnormal_pH_regulation4.18569266
5MP0001984_abnormal_olfaction4.00704800
6MP0002277_abnormal_respiratory_mucosa3.78816862
7MP0009780_abnormal_chondrocyte_physiolo3.51546663
8MP0008789_abnormal_olfactory_epithelium3.51496078
9MP0004133_heterotaxia3.43239352
10MP0005623_abnormal_meninges_morphology3.25355323
11MP0000566_synostosis2.89268167
12MP0005377_hearing/vestibular/ear_phenot2.55795275
13MP0003878_abnormal_ear_physiology2.55795275
14MP0000383_abnormal_hair_follicle2.31717825
15MP0005499_abnormal_olfactory_system2.29740175
16MP0005394_taste/olfaction_phenotype2.29740175
17MP0003656_abnormal_erythrocyte_physiolo2.06423942
18MP0010678_abnormal_skin_adnexa2.04338304
19MP0002282_abnormal_trachea_morphology2.04000524
20MP0001765_abnormal_ion_homeostasis1.97224938
21MP0002168_other_aberrant_phenotype1.89033699
22MP0002160_abnormal_reproductive_system1.88594153
23MP0004019_abnormal_vitamin_homeostasis1.86420164
24MP0005083_abnormal_biliary_tract1.85812978
25MP0000678_abnormal_parathyroid_gland1.72314844
26MP0009379_abnormal_foot_pigmentation1.60005746
27MP0001346_abnormal_lacrimal_gland1.47874375
28MP0010234_abnormal_vibrissa_follicle1.37865638
29MP0005636_abnormal_mineral_homeostasis1.33105664
30MP0002249_abnormal_larynx_morphology1.32666930
31MP0002909_abnormal_adrenal_gland1.32313150
32MP0005248_abnormal_Harderian_gland1.30985402
33MP0005395_other_phenotype1.28621028
34MP0005310_abnormal_salivary_gland1.27081267
35MP0010155_abnormal_intestine_physiology1.26217890
36MP0001929_abnormal_gametogenesis1.25575283
37MP0003698_abnormal_male_reproductive1.21292171
38MP0005165_increased_susceptibility_to1.20593252
39MP0000465_gastrointestinal_hemorrhage1.14754316
40MP0005408_hypopigmentation1.09895753
41MP0002734_abnormal_mechanical_nocicepti1.09004105
42MP0010030_abnormal_orbit_morphology1.08588171
43MP0000681_abnormal_thyroid_gland1.01010442
44MP0002876_abnormal_thyroid_physiology1.00625862
45MP0003303_peritoneal_inflammation0.97310831
46MP0002735_abnormal_chemical_nociception0.96502501
47MP0002233_abnormal_nose_morphology0.94974715
48MP0009643_abnormal_urine_homeostasis0.94944387
49MP0005389_reproductive_system_phenotype0.93544271
50MP0001485_abnormal_pinna_reflex0.92898457
51MP0004264_abnormal_extraembryonic_tissu0.91623812
52MP0005164_abnormal_response_to0.91495756
53MP0002638_abnormal_pupillary_reflex0.87602802
54MP0005409_darkened_coat_color0.86409710
55MP0005365_abnormal_bile_salt0.85808423
56MP0002136_abnormal_kidney_physiology0.85732325
57MP0005410_abnormal_fertilization0.76377342
58MP0003453_abnormal_keratinocyte_physiol0.74865856
59MP0009765_abnormal_xenobiotic_induced0.74284943
60MP0002098_abnormal_vibrissa_morphology0.73525599
61MP0002139_abnormal_hepatobiliary_system0.72675243
62MP0004883_abnormal_blood_vessel0.72110520
63MP0001849_ear_inflammation0.70495519
64MP0003890_abnormal_embryonic-extraembry0.69748804
65MP0001270_distended_abdomen0.69304834
66MP0002405_respiratory_system_inflammati0.66345542
67MP0008995_early_reproductive_senescence0.64584002
68MP0005085_abnormal_gallbladder_physiolo0.64277255
69MP0005253_abnormal_eye_physiology0.60945331
70MP0002161_abnormal_fertility/fecundity0.60336845
71MP0006036_abnormal_mitochondrial_physio0.59141381
72MP0004782_abnormal_surfactant_physiolog0.57917937
73MP0009763_increased_sensitivity_to0.56926724
74MP0000858_altered_metastatic_potential0.56370082
75MP0000467_abnormal_esophagus_morphology0.55809004
76MP0003075_altered_response_to0.55025162
77MP0003191_abnormal_cellular_cholesterol0.54158868
78MP0002928_abnormal_bile_duct0.53197252
79MP0005387_immune_system_phenotype0.53107057
80MP0001790_abnormal_immune_system0.53107057
81MP0000026_abnormal_inner_ear0.52694057
82MP0005220_abnormal_exocrine_pancreas0.51926914
83MP0006082_CNS_inflammation0.51069363
84MP0001663_abnormal_digestive_system0.48343994
85MP0003136_yellow_coat_color0.47275668
86MP0005551_abnormal_eye_electrophysiolog0.46846875
87MP0009703_decreased_birth_body0.46468802
88MP0002822_catalepsy0.46461919
89MP0001293_anophthalmia0.45626828
90MP0001324_abnormal_eye_pigmentation0.44174600
91MP0001727_abnormal_embryo_implantation0.43969530
92MP0003866_abnormal_defecation0.42705550
93MP0001299_abnormal_eye_distance/0.42399467
94MP0001502_abnormal_circadian_rhythm0.42247877
95MP0002135_abnormal_kidney_morphology0.41838868
96MP0001666_abnormal_nutrient_absorption0.41763819
97MP0001664_abnormal_digestion0.41393317
98MP0002084_abnormal_developmental_patter0.41037936
99MP0005388_respiratory_system_phenotype0.40123526
100MP0002133_abnormal_respiratory_system0.40123526

Predicted human phenotypes

RankGene SetZ-score
1Chronic bronchitis (HP:0004469)8.10137415
2Bronchiectasis (HP:0002110)7.62689406
3Nasal polyposis (HP:0100582)6.97744992
4Abnormality of the nasal mucosa (HP:0000433)5.79300708
5Infertility (HP:0000789)4.60578574
6Recurrent sinusitis (HP:0011108)4.36989427
7Bronchitis (HP:0012387)4.34878492
8Chronic sinusitis (HP:0011109)4.27793549
9Male infertility (HP:0003251)4.08689318
10Recurrent otitis media (HP:0000403)3.92467331
11Occipital encephalocele (HP:0002085)3.48760516
12Pancreatic fibrosis (HP:0100732)3.31965751
13Atelectasis (HP:0100750)3.29986708
14True hermaphroditism (HP:0010459)3.24319456
15Chronic otitis media (HP:0000389)3.13428351
16Hyperactive renin-angiotensin system (HP:0000841)2.99398582
17Cystic liver disease (HP:0006706)2.71370903
18Molar tooth sign on MRI (HP:0002419)2.70346728
19Abnormality of midbrain morphology (HP:0002418)2.70346728
20Nephronophthisis (HP:0000090)2.63571933
21Pancreatic cysts (HP:0001737)2.62679624
22Chronic hepatic failure (HP:0100626)2.51590325
23Postaxial foot polydactyly (HP:0001830)2.30259941
24Tubulointerstitial nephritis (HP:0001970)2.25082821
25Bell-shaped thorax (HP:0001591)2.10231713
26Abnormality of the renal medulla (HP:0100957)2.03390621
27Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.5699052
28Abnormal respiratory epithelium morphology (HP:0012253)11.5390477
29Abnormal respiratory motile cilium morphology (HP:0005938)11.5390477
30Abnormal respiratory motile cilium physiology (HP:0012261)11.1268662
31Absent/shortened dynein arms (HP:0200106)10.8304599
32Dynein arm defect of respiratory motile cilia (HP:0012255)10.8304599
33Abnormal ciliary motility (HP:0012262)10.7577881
34Rhinitis (HP:0012384)10.2936921
35Congenital hepatic fibrosis (HP:0002612)1.93239505
36Anencephaly (HP:0002323)1.92616090
37Decreased circulating renin level (HP:0003351)1.84486954
38Medial flaring of the eyebrow (HP:0010747)1.83637082
39Aplasia/Hypoplasia of the tongue (HP:0010295)1.83283204
40Renal salt wasting (HP:0000127)1.82266887
41Absent frontal sinuses (HP:0002688)1.81859454
42Male pseudohermaphroditism (HP:0000037)1.79263608
43Recurrent bronchitis (HP:0002837)1.76887983
44Hyperkalemia (HP:0002153)1.75156640
45Congenital primary aphakia (HP:0007707)1.74389968
46Asplenia (HP:0001746)1.74286574
47Aplasia/Hypoplasia of the spleen (HP:0010451)1.72305724
48Gait imbalance (HP:0002141)1.70789855
49Nephropathy (HP:0000112)1.62189336
50Oculomotor apraxia (HP:0000657)1.57500779
51Sclerocornea (HP:0000647)1.53307603
52Furrowed tongue (HP:0000221)1.52092217
53Tubular atrophy (HP:0000092)1.51314839
54Nephrogenic diabetes insipidus (HP:0009806)1.49931124
55Postaxial hand polydactyly (HP:0001162)1.48514273
56Hyperaldosteronism (HP:0000859)1.47893301
57Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.38920236
58Abnormality of chloride homeostasis (HP:0011422)1.38261069
59Abnormality of renin-angiotensin system (HP:0000847)1.33152451
60Median cleft lip (HP:0000161)1.31536232
61Cone-rod dystrophy (HP:0000548)1.26725328
62Preaxial hand polydactyly (HP:0001177)1.25842691
63Fetal akinesia sequence (HP:0001989)1.25729007
64Stage 5 chronic kidney disease (HP:0003774)1.24186907
65Hypokalemic alkalosis (HP:0001949)1.23364324
66Short thorax (HP:0010306)1.22393134
67Hyponatremia (HP:0002902)1.21045092
68Poor coordination (HP:0002370)1.20890785
69Hand muscle atrophy (HP:0009130)1.19882378
70Decreased central vision (HP:0007663)1.18522222
71Absent rod-and cone-mediated responses on ERG (HP:0007688)1.17874393
72Tubulointerstitial abnormality (HP:0001969)1.17589073
73Genital tract atresia (HP:0001827)1.16990067
74Vaginal atresia (HP:0000148)1.16835907
75Abnormality of the distal phalanges of the toes (HP:0010182)1.15297381
76Supernumerary spleens (HP:0009799)1.14088952
77Bifid scrotum (HP:0000048)1.13885759
78Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.12984056
79Glucose intolerance (HP:0000833)1.12771629
80Short nail (HP:0001799)1.12360595
81Abnormality of permanent molar morphology (HP:0011071)1.12280134
82Abnormality of the dental root (HP:0006486)1.12280134
83Taurodontia (HP:0000679)1.12280134
84Abnormality of the frontal sinuses (HP:0002687)1.09009052
85Popliteal pterygium (HP:0009756)1.08535086
86Lip pit (HP:0100267)1.04690029
87Abnormality of macular pigmentation (HP:0008002)1.04334126
88Abnormality of molar morphology (HP:0011070)1.02034812
89Abnormality of molar (HP:0011077)1.02034812
90Polydipsia (HP:0001959)1.01565735
91Abnormal drinking behavior (HP:0030082)1.01565735
92Abnormality of the dental pulp (HP:0006479)1.01150811
93Abnormality of monocarboxylic acid metabolism (HP:0010996)0.97058985
94Flat acetabular roof (HP:0003180)0.96617474
95Short femoral neck (HP:0100864)0.96517468
96Absent speech (HP:0001344)0.96062608
97Aplasia of the musculature (HP:0100854)0.93758645
98Obstructive sleep apnea (HP:0002870)0.93710771
99Retinitis pigmentosa (HP:0000510)0.92156458
100Muscle fiber splitting (HP:0003555)0.91310379

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.47416303
2EPHA24.81225406
3NME12.14924390
4MAP3K22.08285940
5SMG12.07681357
6MAPK1511.8027526
7MAPKAPK31.99699354
8PNCK1.98235063
9STK241.91778857
10PTK2B1.82726856
11TTK1.71209168
12MAP3K31.52274000
13NEK61.49899818
14CSK1.48469311
15EEF2K1.47144579
16TESK11.31174205
17PLK41.28554445
18MST1R1.25658597
19LRRK21.24002454
20BCR1.22036768
21BRSK21.08373312
22EPHB11.08241499
23MARK21.02002046
24STK101.01112045
25STK380.98158821
26MAP3K120.98128737
27TLK10.96836211
28RIPK40.89910389
29CAMKK10.88960427
30TBK10.86492204
31PRKCI0.85455561
32MAP3K70.85390962
33INSRR0.80551279
34TRPM70.71733720
35ERBB30.71042257
36BRD40.69811757
37CAMKK20.67042754
38CDK120.64029979
39STK160.63938499
40ERBB20.57958958
41ICK0.57419922
42GRK60.55140110
43PDPK10.53595312
44TRIB30.53566255
45MET0.52309649
46PRKAA20.50581997
47AURKA0.49443347
48SGK10.46644394
49DYRK1B0.46326563
50PRKD30.45030223
51EPHA30.44932080
52PRKCD0.42143390
53CAMK2G0.41268698
54PRKCQ0.41027975
55IRAK10.39800819
56CDK60.39066794
57RIPK10.38541283
58MAP3K110.36674701
59PLK10.33595008
60MAP3K40.32113067
61TAOK10.32065729
62MAP2K20.31482225
63EPHA40.30017544
64NLK0.29891474
65HIPK20.29649439
66CAMK1G0.28935741
67STK38L0.28643232
68MAP2K40.27033848
69PDK10.25869731
70PAK40.23851410
71ACVR1B0.23532708
72PAK10.23339271
73OXSR10.23310326
74RPS6KB20.23147571
75PBK0.22504736
76FER0.22294016
77ROCK10.21267711
78CHEK20.20696012
79PRKACA0.20133900
80DYRK1A0.18985355
81RET0.18551073
82CDC42BPA0.18404191
83LMTK20.17438484
84TYK20.17170154
85NEK90.16708342
86FYN0.16232849
87PRKCA0.15166709
88PRKCZ0.14670716
89ARAF0.14545707
90ADRBK10.14423125
91ABL10.14407992
92PTK60.13876467
93ZAP700.13262217
94PLK20.12812811
95MAP2K70.11557050
96FGFR30.11428467
97SRC0.11355184
98ROCK20.10055172
99KSR20.09764412
100CAMK2A0.09504088

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.85900775
2Phenylalanine metabolism_Homo sapiens_hsa003605.11064247
3Chemical carcinogenesis_Homo sapiens_hsa052044.64586439
4Histidine metabolism_Homo sapiens_hsa003404.48941011
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.35043175
6Tyrosine metabolism_Homo sapiens_hsa003503.92478720
7beta-Alanine metabolism_Homo sapiens_hsa004102.99557206
8Huntingtons disease_Homo sapiens_hsa050162.72096400
9Glutathione metabolism_Homo sapiens_hsa004802.68798314
10Caffeine metabolism_Homo sapiens_hsa002322.62964110
11Retinol metabolism_Homo sapiens_hsa008302.41224861
12Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.89630443
13Linoleic acid metabolism_Homo sapiens_hsa005911.85823446
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.84449169
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.83057132
16Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.74492813
17Sphingolipid metabolism_Homo sapiens_hsa006001.62672448
18Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.61556485
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.55391147
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.46768495
21Fatty acid degradation_Homo sapiens_hsa000711.44046236
22Tight junction_Homo sapiens_hsa045301.30168924
23ABC transporters_Homo sapiens_hsa020101.28722663
24Peroxisome_Homo sapiens_hsa041461.18901737
25Carbohydrate digestion and absorption_Homo sapiens_hsa049731.11783857
26Salivary secretion_Homo sapiens_hsa049701.11351016
27Arachidonic acid metabolism_Homo sapiens_hsa005900.99478928
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93864911
29Drug metabolism - other enzymes_Homo sapiens_hsa009830.92782744
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88473346
31Starch and sucrose metabolism_Homo sapiens_hsa005000.88426122
32Circadian rhythm_Homo sapiens_hsa047100.82096864
33Fatty acid biosynthesis_Homo sapiens_hsa000610.81583964
34Glycerophospholipid metabolism_Homo sapiens_hsa005640.78575973
35Choline metabolism in cancer_Homo sapiens_hsa052310.76715238
36Notch signaling pathway_Homo sapiens_hsa043300.75210159
37Collecting duct acid secretion_Homo sapiens_hsa049660.73844012
38Hepatitis C_Homo sapiens_hsa051600.70262143
39Olfactory transduction_Homo sapiens_hsa047400.69675736
40Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66532345
41Leukocyte transendothelial migration_Homo sapiens_hsa046700.65346957
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63778210
43Taste transduction_Homo sapiens_hsa047420.63144453
44Primary bile acid biosynthesis_Homo sapiens_hsa001200.57552607
45PPAR signaling pathway_Homo sapiens_hsa033200.56076662
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52247802
47Adherens junction_Homo sapiens_hsa045200.50932333
48Hedgehog signaling pathway_Homo sapiens_hsa043400.47633663
49Hematopoietic cell lineage_Homo sapiens_hsa046400.47182853
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47168100
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39737946
52Complement and coagulation cascades_Homo sapiens_hsa046100.39120084
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33655488
54Lysosome_Homo sapiens_hsa041420.32669339
55Amoebiasis_Homo sapiens_hsa051460.31128871
56Type I diabetes mellitus_Homo sapiens_hsa049400.29598014
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29179303
58Jak-STAT signaling pathway_Homo sapiens_hsa046300.28804986
59Metabolic pathways_Homo sapiens_hsa011000.28752757
60Nicotine addiction_Homo sapiens_hsa050330.28039932
61Phototransduction_Homo sapiens_hsa047440.27902945
62Regulation of autophagy_Homo sapiens_hsa041400.27310998
63Allograft rejection_Homo sapiens_hsa053300.26102702
64Autoimmune thyroid disease_Homo sapiens_hsa053200.24642638
65cAMP signaling pathway_Homo sapiens_hsa040240.24354184
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24220236
67Basal cell carcinoma_Homo sapiens_hsa052170.23884866
68Glycerolipid metabolism_Homo sapiens_hsa005610.23694201
69Cocaine addiction_Homo sapiens_hsa050300.23431206
70Synaptic vesicle cycle_Homo sapiens_hsa047210.19727525
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.19681435
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19006418
73Graft-versus-host disease_Homo sapiens_hsa053320.17822313
74Endocytosis_Homo sapiens_hsa041440.17820381
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.17810025
76Arginine and proline metabolism_Homo sapiens_hsa003300.17476384
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.17407598
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16181442
79Nucleotide excision repair_Homo sapiens_hsa034200.15171280
80Serotonergic synapse_Homo sapiens_hsa047260.14908080
81Insulin resistance_Homo sapiens_hsa049310.14489911
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.14290321
83Phagosome_Homo sapiens_hsa041450.14288418
84Antigen processing and presentation_Homo sapiens_hsa046120.13358909
85Vitamin digestion and absorption_Homo sapiens_hsa049770.13152610
86Pancreatic secretion_Homo sapiens_hsa049720.12970640
87Calcium signaling pathway_Homo sapiens_hsa040200.12593763
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.12275311
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.11402399
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.11104024
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.10758579
92Asthma_Homo sapiens_hsa053100.10626790
93Prostate cancer_Homo sapiens_hsa052150.09977167
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.09724458
95Amphetamine addiction_Homo sapiens_hsa050310.09234664
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.07933261
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.07474175
98Vibrio cholerae infection_Homo sapiens_hsa051100.06897372
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.06608226
100Bile secretion_Homo sapiens_hsa049760.05032573

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