C1ORF186

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.50122330
2piRNA metabolic process (GO:0034587)3.86533660
3negative regulation of B cell apoptotic process (GO:0002903)3.72015300
4regulation of B cell apoptotic process (GO:0002902)3.66703225
5positive regulation of B cell differentiation (GO:0045579)3.56802816
6indole-containing compound catabolic process (GO:0042436)3.46768538
7indolalkylamine catabolic process (GO:0046218)3.46768538
8tryptophan catabolic process (GO:0006569)3.46768538
9definitive hemopoiesis (GO:0060216)3.45274454
10tryptophan metabolic process (GO:0006568)3.40658895
11platelet dense granule organization (GO:0060155)3.39784070
12pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.35150131
13cellular response to exogenous dsRNA (GO:0071360)3.33420234
14regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.27410402
15base-excision repair, AP site formation (GO:0006285)3.26241273
16indolalkylamine metabolic process (GO:0006586)3.24321042
17purinergic nucleotide receptor signaling pathway (GO:0035590)3.21096191
18L-fucose metabolic process (GO:0042354)3.20279498
19L-fucose catabolic process (GO:0042355)3.20279498
20fucose catabolic process (GO:0019317)3.20279498
21response to protozoan (GO:0001562)3.19230652
22positive regulation of prostaglandin secretion (GO:0032308)3.11667552
23cytidine metabolic process (GO:0046087)3.05383375
24cytidine catabolic process (GO:0006216)3.05383375
25cytidine deamination (GO:0009972)3.05383375
26response to interferon-beta (GO:0035456)3.02762048
27preassembly of GPI anchor in ER membrane (GO:0016254)2.98521863
28immunoglobulin mediated immune response (GO:0016064)2.96367463
29axoneme assembly (GO:0035082)2.94183117
30regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.93680334
31autophagic vacuole fusion (GO:0000046)2.88991591
32pyrimidine nucleotide catabolic process (GO:0006244)2.84575138
33deoxyribonucleotide catabolic process (GO:0009264)2.80128139
34DNA methylation involved in gamete generation (GO:0043046)2.79743252
35B cell receptor signaling pathway (GO:0050853)2.72709897
36positive regulation of defense response to virus by host (GO:0002230)2.69567965
37organelle membrane fusion (GO:0090174)2.69480873
38defense response to protozoan (GO:0042832)2.69349553
39positive regulation of granulocyte differentiation (GO:0030854)2.68547145
40deoxyribose phosphate catabolic process (GO:0046386)2.67493103
41regulation of B cell differentiation (GO:0045577)2.64140454
42epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.63663518
43neural tube formation (GO:0001841)2.63413665
44pyrimidine ribonucleoside catabolic process (GO:0046133)2.62842557
45negative regulation of metanephros development (GO:0072217)2.59086611
46pseudouridine synthesis (GO:0001522)2.59039778
47mannosylation (GO:0097502)2.58974514
48positive regulation of icosanoid secretion (GO:0032305)2.58339579
49mast cell degranulation (GO:0043303)2.57498409
50mast cell activation involved in immune response (GO:0002279)2.57498409
51male meiosis I (GO:0007141)2.56690968
52S-adenosylmethionine metabolic process (GO:0046500)2.55852969
53GPI anchor metabolic process (GO:0006505)2.53529946
54cellular biogenic amine catabolic process (GO:0042402)2.52020857
55amine catabolic process (GO:0009310)2.52020857
56thrombin receptor signaling pathway (GO:0070493)2.51721370
57positive regulation of fatty acid transport (GO:2000193)2.50705750
58aromatic amino acid family catabolic process (GO:0009074)2.50565173
59L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.50253962
60positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.47641631
61B cell mediated immunity (GO:0019724)2.47229578
62GPI anchor biosynthetic process (GO:0006506)2.47099492
63negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.44665111
64amino acid salvage (GO:0043102)2.44442763
65L-methionine salvage (GO:0071267)2.44442763
66L-methionine biosynthetic process (GO:0071265)2.44442763
67DNA dealkylation (GO:0035510)2.44197971
68cytokine biosynthetic process (GO:0042089)2.43879667
69parturition (GO:0007567)2.42165584
70kynurenine metabolic process (GO:0070189)2.41417508
71regulation of B cell receptor signaling pathway (GO:0050855)2.39506384
72protein complex biogenesis (GO:0070271)2.39434820
73seminiferous tubule development (GO:0072520)2.38572919
74mast cell activation (GO:0045576)2.38503326
75aggressive behavior (GO:0002118)2.38106925
76regulation of respiratory burst (GO:0060263)2.37994758
77tyrosine phosphorylation of STAT protein (GO:0007260)2.37097792
78nephron tubule formation (GO:0072079)2.36560380
79detection of light stimulus involved in visual perception (GO:0050908)2.36366296
80detection of light stimulus involved in sensory perception (GO:0050962)2.36366296
81mature B cell differentiation involved in immune response (GO:0002313)2.35713412
82photoreceptor cell maintenance (GO:0045494)2.35572430
83branched-chain amino acid catabolic process (GO:0009083)2.34626791
84iron-sulfur cluster assembly (GO:0016226)2.34367712
85metallo-sulfur cluster assembly (GO:0031163)2.34367712
86DNA demethylation (GO:0080111)2.34331274
87response to pheromone (GO:0019236)2.32972898
88arginine catabolic process (GO:0006527)2.32730595
89B cell differentiation (GO:0030183)2.31900854
90positive regulation of megakaryocyte differentiation (GO:0045654)2.31093565
91positive regulation of histone H3-K4 methylation (GO:0051571)2.30807782
92negative regulation of calcium ion transport into cytosol (GO:0010523)2.30634570
93ubiquinone biosynthetic process (GO:0006744)2.30570625
94regulation of prostaglandin secretion (GO:0032306)2.30301789
95cellular response to interferon-beta (GO:0035458)2.29564194
96mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.29308581
97mitochondrial respiratory chain complex I assembly (GO:0032981)2.29308581
98NADH dehydrogenase complex assembly (GO:0010257)2.29308581
99NAD biosynthetic process (GO:0009435)2.27055808
100negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.26157420

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.99005830
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.89649770
3ZNF274_21170338_ChIP-Seq_K562_Hela3.60014374
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.04495020
5VDR_22108803_ChIP-Seq_LS180_Human2.89401162
6SCL_19346495_ChIP-Seq_HPC-7_Human2.60737200
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.60707450
8IGF1R_20145208_ChIP-Seq_DFB_Human2.50528219
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.42885756
10CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.16260416
11LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.14695598
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.07748433
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92045117
14EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.88141783
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.85944120
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84366786
17VDR_23849224_ChIP-Seq_CD4+_Human1.83404484
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.83390645
19ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81674342
20* GATA3_26560356_Chip-Seq_TH2_Human1.67734812
21MYB_26560356_Chip-Seq_TH2_Human1.67540533
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55963786
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.53695307
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.52620879
25EWS_26573619_Chip-Seq_HEK293_Human1.51678306
26ER_23166858_ChIP-Seq_MCF-7_Human1.51574261
27TP53_22573176_ChIP-Seq_HFKS_Human1.47432636
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46931098
29FOXP3_21729870_ChIP-Seq_TREG_Human1.45373771
30IRF8_21731497_ChIP-ChIP_J774_Mouse1.44068868
31IRF1_19129219_ChIP-ChIP_H3396_Human1.42693034
32CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.41475706
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40731327
34LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39997435
35AR_20517297_ChIP-Seq_VCAP_Human1.39794173
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39454140
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.38328270
38CBP_20019798_ChIP-Seq_JUKART_Human1.37023768
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37023768
40* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34438991
41* FOXA1_25329375_ChIP-Seq_VCAP_Human1.34438991
42PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.33956498
43CIITA_25753668_ChIP-Seq_RAJI_Human1.32842515
44GATA3_27048872_Chip-Seq_THYMUS_Human1.32801154
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.32524776
46FOXA1_21572438_ChIP-Seq_LNCaP_Human1.31676105
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31374766
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.29698531
49SOX2_19829295_ChIP-Seq_ESCs_Human1.26217806
50NANOG_19829295_ChIP-Seq_ESCs_Human1.26217806
51* SPI1_23547873_ChIP-Seq_NB4_Human1.26200695
52VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.24788742
53* GATA3_21878914_ChIP-Seq_MCF-7_Human1.22773099
54EST1_17652178_ChIP-ChIP_JURKAT_Human1.21764899
55NANOG_20526341_ChIP-Seq_ESCs_Human1.20496377
56ERA_21632823_ChIP-Seq_H3396_Human1.20067651
57FUS_26573619_Chip-Seq_HEK293_Human1.19869713
58KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.18924897
59MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.18808266
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17880286
61P300_19829295_ChIP-Seq_ESCs_Human1.16094611
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14593663
63RUNX_20019798_ChIP-Seq_JUKART_Human1.14014298
64GBX2_23144817_ChIP-Seq_PC3_Human1.13159202
65ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13036174
66STAT1_20625510_ChIP-Seq_HELA_Human1.12123924
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10841288
68NCOR_22424771_ChIP-Seq_293T_Human1.10192515
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10055382
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10023295
71* MYB_26560356_Chip-Seq_TH1_Human1.08854445
72JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.08020802
73GATA1_22025678_ChIP-Seq_K562_Human1.07540525
74BCAT_22108803_ChIP-Seq_LS180_Human1.06693627
75ELK1_19687146_ChIP-ChIP_HELA_Human1.05867672
76* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04277498
77SMRT_27268052_Chip-Seq_Bcells_Human1.04169581
78GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02942534
79HOXB7_26014856_ChIP-Seq_BT474_Human1.02592986
80CEBPB_22108803_ChIP-Seq_LS180_Human1.02351080
81MYC_18940864_ChIP-ChIP_HL60_Human1.02134885
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.01542799
83EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01372005
84P53_21459846_ChIP-Seq_SAOS-2_Human1.00898215
85HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99432512
86SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99239230
87FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99024173
88VDR_24787735_ChIP-Seq_THP-1_Human0.98670443
89ETS1_20019798_ChIP-Seq_JURKAT_Human0.95827726
90SALL1_21062744_ChIP-ChIP_HESCs_Human0.95502995
91ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93361964
92PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93180361
93* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93061378
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.92642078
95CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90439829
96FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90281673
97TAF2_19829295_ChIP-Seq_ESCs_Human0.89893896
98* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88968912
99P300_27268052_Chip-Seq_Bcells_Human0.88927553
100CDX2_22108803_ChIP-Seq_LS180_Human0.87469609

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system3.16503838
2MP0003195_calcinosis2.92197198
3MP0001835_abnormal_antigen_presentation2.75799013
4MP0005084_abnormal_gallbladder_morpholo2.73602501
5MP0010386_abnormal_urinary_bladder2.50345367
6MP0000372_irregular_coat_pigmentation2.46846130
7MP0005645_abnormal_hypothalamus_physiol2.31086479
8MP0005075_abnormal_melanosome_morpholog2.11564774
9MP0002396_abnormal_hematopoietic_system2.05830540
10MP0005646_abnormal_pituitary_gland1.99592579
11MP0001800_abnormal_humoral_immune1.91433910
12MP0002928_abnormal_bile_duct1.87924266
13MP0001545_abnormal_hematopoietic_system1.87490372
14MP0005397_hematopoietic_system_phenotyp1.87490372
15MP0005464_abnormal_platelet_physiology1.86860396
16MP0009278_abnormal_bone_marrow1.85445213
17MP0003252_abnormal_bile_duct1.84307570
18MP0008058_abnormal_DNA_repair1.78556398
19MP0003183_abnormal_peptide_metabolism1.76267987
20MP0002876_abnormal_thyroid_physiology1.75128343
21MP0002148_abnormal_hypersensitivity_rea1.71421102
22MP0008872_abnormal_physiological_respon1.70906650
23MP0003806_abnormal_nucleotide_metabolis1.57523538
24MP0001986_abnormal_taste_sensitivity1.57324192
25MP0008877_abnormal_DNA_methylation1.56754087
26MP0002452_abnormal_antigen_presenting1.55578422
27MP0009785_altered_susceptibility_to1.53169734
28MP0000685_abnormal_immune_system1.51572249
29MP0001764_abnormal_homeostasis1.50970071
30MP0002723_abnormal_immune_serum1.50461284
31MP0001790_abnormal_immune_system1.48453258
32MP0005387_immune_system_phenotype1.48453258
33MP0002420_abnormal_adaptive_immunity1.48269106
34MP0002160_abnormal_reproductive_system1.48079141
35MP0001819_abnormal_immune_cell1.47671771
36MP0003718_maternal_effect1.42686945
37MP0004147_increased_porphyrin_level1.42514432
38MP0004808_abnormal_hematopoietic_stem1.41232103
39MP0003724_increased_susceptibility_to1.41056048
40MP0003763_abnormal_thymus_physiology1.40069821
41MP0001501_abnormal_sleep_pattern1.38741522
42MP0005671_abnormal_response_to1.36537215
43MP0005551_abnormal_eye_electrophysiolog1.34221572
44MP0000465_gastrointestinal_hemorrhage1.33657793
45MP0000681_abnormal_thyroid_gland1.33637431
46MP0002398_abnormal_bone_marrow1.33317778
47MP0005025_abnormal_response_to1.33306576
48MP0008995_early_reproductive_senescence1.31999681
49MP0008875_abnormal_xenobiotic_pharmacok1.31449145
50MP0005220_abnormal_exocrine_pancreas1.31404352
51MP0001873_stomach_inflammation1.30456609
52MP0002139_abnormal_hepatobiliary_system1.30166486
53MP0000716_abnormal_immune_system1.29635533
54MP0000689_abnormal_spleen_morphology1.27715940
55MP0005000_abnormal_immune_tolerance1.27262489
56MP0005389_reproductive_system_phenotype1.24845091
57MP0005410_abnormal_fertilization1.19379003
58MP0006082_CNS_inflammation1.18911251
59MP0002419_abnormal_innate_immunity1.16717768
60MP0005174_abnormal_tail_pigmentation1.15747112
61MP0005332_abnormal_amino_acid1.14285770
62MP0003787_abnormal_imprinting1.13174272
63MP0003638_abnormal_response/metabolism_1.12831203
64MP0006036_abnormal_mitochondrial_physio1.11167288
65MP0006292_abnormal_olfactory_placode1.10628569
66MP0002429_abnormal_blood_cell1.06718610
67MP0004043_abnormal_pH_regulation1.06133567
68MP0001968_abnormal_touch/_nociception1.03903584
69MP0002735_abnormal_chemical_nociception1.02454944
70MP0002722_abnormal_immune_system1.01298430
71MP0008057_abnormal_DNA_replication1.01022835
72MP0009643_abnormal_urine_homeostasis1.00333655
73MP0002405_respiratory_system_inflammati1.00117962
74MP0003943_abnormal_hepatobiliary_system0.99548545
75MP0006276_abnormal_autonomic_nervous0.98716421
76MP0000015_abnormal_ear_pigmentation0.98389420
77MP0005360_urolithiasis0.97564063
78MP0005085_abnormal_gallbladder_physiolo0.97204813
79MP0001905_abnormal_dopamine_level0.94748933
80MP0009764_decreased_sensitivity_to0.94337512
81MP0002102_abnormal_ear_morphology0.92988357
82MP0003646_muscle_fatigue0.91836728
83MP0001845_abnormal_inflammatory_respons0.90056609
84MP0009333_abnormal_splenocyte_physiolog0.88457520
85MP0002132_abnormal_respiratory_system0.85455757
86MP0009765_abnormal_xenobiotic_induced0.84750988
87MP0008469_abnormal_protein_level0.83871178
88MP0001929_abnormal_gametogenesis0.81299645
89MP0004019_abnormal_vitamin_homeostasis0.80547767
90MP0001664_abnormal_digestion0.80500003
91MP0002163_abnormal_gland_morphology0.80434122
92MP0003436_decreased_susceptibility_to0.78457619
93MP0000230_abnormal_systemic_arterial0.78373386
94MP0010329_abnormal_lipoprotein_level0.78156892
95MP0001919_abnormal_reproductive_system0.77839913
96MP0010155_abnormal_intestine_physiology0.77272511
97MP0003866_abnormal_defecation0.76257763
98MP0002136_abnormal_kidney_physiology0.75854174
99MP0001881_abnormal_mammary_gland0.75089992
100MP0002693_abnormal_pancreas_physiology0.73001442

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)4.36821829
2Hypothermia (HP:0002045)3.85964006
3Panhypogammaglobulinemia (HP:0003139)3.76412620
4Abnormality of B cell number (HP:0010975)3.68547151
5Thyroid-stimulating hormone excess (HP:0002925)3.61681666
6Absent rod-and cone-mediated responses on ERG (HP:0007688)3.33390768
7Pancreatic cysts (HP:0001737)3.29198800
8Abnormal drinking behavior (HP:0030082)3.15544912
9Polydipsia (HP:0001959)3.15544912
10Congenital stationary night blindness (HP:0007642)3.12792573
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.12482950
12B lymphocytopenia (HP:0010976)3.10955316
13Stomach cancer (HP:0012126)3.10062103
14Attenuation of retinal blood vessels (HP:0007843)3.06437090
15Acute lymphatic leukemia (HP:0006721)3.04781713
16Abnormal rod and cone electroretinograms (HP:0008323)3.00552370
17Tetany (HP:0001281)2.99321329
18Decreased central vision (HP:0007663)2.96369539
19Abnormality of the prostate (HP:0008775)2.95730686
20Hypomagnesemia (HP:0002917)2.93050859
21Elevated erythrocyte sedimentation rate (HP:0003565)2.86965471
22Autoimmune hemolytic anemia (HP:0001890)2.75677369
23Decreased electroretinogram (ERG) amplitude (HP:0000654)2.74030392
24Molar tooth sign on MRI (HP:0002419)2.68966716
25Abnormality of midbrain morphology (HP:0002418)2.68966716
26Abolished electroretinogram (ERG) (HP:0000550)2.60922832
27Abnormality of T cell physiology (HP:0011840)2.60732717
28Abnormality of the renal cortex (HP:0011035)2.51011855
29Recurrent fungal infections (HP:0002841)2.48700710
30Polyuria (HP:0000103)2.44899442
31Chronic otitis media (HP:0000389)2.39875114
32Abnormality of the renal medulla (HP:0100957)2.38935322
33Recurrent cutaneous fungal infections (HP:0011370)2.36483362
34Chronic mucocutaneous candidiasis (HP:0002728)2.36483362
35Pancreatic fibrosis (HP:0100732)2.31546818
36Abnormal biliary tract physiology (HP:0012439)2.30150492
37Bile duct proliferation (HP:0001408)2.30150492
383-Methylglutaconic aciduria (HP:0003535)2.29295300
39Nephronophthisis (HP:0000090)2.28372942
40True hermaphroditism (HP:0010459)2.27391193
41Abnormality of macular pigmentation (HP:0008002)2.24734955
42Meningitis (HP:0001287)2.23830803
43Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.22981169
44Abnormal protein N-linked glycosylation (HP:0012347)2.22981169
45Abnormal protein glycosylation (HP:0012346)2.22981169
46Abnormal glycosylation (HP:0012345)2.22981169
47Mitochondrial inheritance (HP:0001427)2.21535772
48Type I transferrin isoform profile (HP:0003642)2.18468782
49Abnormality of male internal genitalia (HP:0000022)2.16514577
50Increased CSF lactate (HP:0002490)2.13668295
51Dicarboxylic aciduria (HP:0003215)2.10700848
52Abnormality of dicarboxylic acid metabolism (HP:0010995)2.10700848
53Ketosis (HP:0001946)2.07766822
54Albinism (HP:0001022)2.07427769
55Hepatocellular necrosis (HP:0001404)2.05111091
56Granulocytopenia (HP:0001913)2.02722631
57Methylmalonic aciduria (HP:0012120)2.02399991
58Severe combined immunodeficiency (HP:0004430)2.00586554
59Chronic hepatic failure (HP:0100626)1.99484675
60Abnormal urine output (HP:0012590)1.99167200
61Prostate neoplasm (HP:0100787)1.98923890
62Aplastic anemia (HP:0001915)1.97407656
63Eosinophilia (HP:0001880)1.96194832
64Abnormality of magnesium homeostasis (HP:0004921)1.95649893
65Constricted visual fields (HP:0001133)1.94900950
66Cystic liver disease (HP:0006706)1.94626151
67Thyroiditis (HP:0100646)1.94199938
68Type II lissencephaly (HP:0007260)1.93734587
69Recurrent viral infections (HP:0004429)1.92182777
70Abnormality of T cells (HP:0002843)1.90450579
71Medial flaring of the eyebrow (HP:0010747)1.89664177
72Hepatic necrosis (HP:0002605)1.86838304
73Autoimmune thrombocytopenia (HP:0001973)1.84347878
74Chronic sinusitis (HP:0011109)1.83604758
75IgG deficiency (HP:0004315)1.83221315
76Neutropenia (HP:0001875)1.81785693
77Mediastinal lymphadenopathy (HP:0100721)1.81550538
78Tubulointerstitial nephritis (HP:0001970)1.81237726
79Cerebral palsy (HP:0100021)1.79576262
80Chronic diarrhea (HP:0002028)1.78819055
81Abnormality of renal excretion (HP:0011036)1.78329946
82Increased serum lactate (HP:0002151)1.76773608
83Thrombocytosis (HP:0001894)1.76641670
84Tubular atrophy (HP:0000092)1.75348737
85Lethargy (HP:0001254)1.74223593
86Aplasia/hypoplasia of the uterus (HP:0008684)1.73557872
87Clumsiness (HP:0002312)1.73263371
88Abnormality of eosinophils (HP:0001879)1.72414570
89Stomatitis (HP:0010280)1.72154990
90Increased hepatocellular lipid droplets (HP:0006565)1.70010281
91Lipid accumulation in hepatocytes (HP:0006561)1.69956821
92Renal cortical cysts (HP:0000803)1.69229314
93Hyperglycinuria (HP:0003108)1.66834337
94Optic disc pallor (HP:0000543)1.65938877
95Recurrent bronchitis (HP:0002837)1.65927893
96Renal Fanconi syndrome (HP:0001994)1.65347405
97Macular degeneration (HP:0000608)1.65146723
98Acute necrotizing encephalopathy (HP:0006965)1.65031033
99Encephalitis (HP:0002383)1.64457691
100Increased intramyocellular lipid droplets (HP:0012240)1.64455546

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.43885404
2FRK4.34040946
3BCKDK3.75207146
4KIT2.97399258
5BMPR1B2.91749086
6MAP4K22.75988010
7NUAK12.44650468
8TEC2.35933522
9ADRBK22.30786832
10FLT32.24792857
11TLK12.03316535
12PINK11.93688282
13TXK1.88139148
14ACVR1B1.84859354
15GRK11.83661814
16MAP4K11.81616633
17EIF2AK31.71129257
18VRK21.64087184
19ZAK1.60643815
20CSF1R1.58019759
21BTK1.54346440
22SYK1.47662525
23IKBKB1.37291567
24INSRR1.33800792
25ITK1.29926309
26VRK11.29294902
27MAPKAPK31.28914507
28BMPR21.26636537
29FES1.25416650
30IKBKE1.22292979
31PDK21.16162294
32DAPK21.15322345
33PRKCQ1.12818359
34PIK3CA1.03578150
35MATK1.03527063
36TNK21.03502232
37TBK11.01510453
38TGFBR10.98187159
39ERN10.95319546
40KDR0.95020000
41MKNK20.91744736
42LYN0.91000340
43OXSR10.87790788
44PIK3CG0.87531655
45TRIM280.85424979
46MARK30.84542013
47WNK30.81751481
48MAPK130.81593952
49ADRBK10.80807848
50MST40.79299930
51MKNK10.78495099
52GRK60.76550753
53MAPK150.73772578
54CDK190.73423256
55LCK0.73252613
56RPS6KA50.71158210
57DAPK10.66929179
58MAP3K140.65431020
59TIE10.65309389
60PKN10.64758628
61HCK0.64596965
62NLK0.63684708
63MAP3K130.62098717
64CSNK1G30.61807491
65JAK30.60734523
66CSNK1G10.60470311
67NEK20.59378199
68PRKCE0.56083426
69ATR0.55936617
70PIM10.55867878
71ABL10.55839397
72MAP3K70.50580468
73STK160.49562807
74RPS6KB20.49410539
75TRPM70.48597131
76IGF1R0.48574369
77MAP3K40.47507513
78MAP2K70.44681293
79CCNB10.42566359
80IRAK10.41952129
81RIPK40.41724595
82MAP2K60.40470744
83WNK40.40334435
84CSNK1A10.40118632
85MAPKAPK50.39440822
86CHUK0.38556665
87CSNK1G20.38524354
88ERBB30.38340864
89FER0.37265143
90CDK30.37232302
91RPS6KA60.36842065
92EIF2AK20.34835004
93PRKCA0.34349605
94PLK40.33508802
95STK38L0.33359955
96CDK80.33124868
97CSNK1A1L0.32182458
98MAPK30.32166133
99RPS6KA40.30753532
100CSNK2A10.30108657

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.97266446
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.58732161
3Allograft rejection_Homo sapiens_hsa053302.78628896
4Graft-versus-host disease_Homo sapiens_hsa053322.69130027
5Autoimmune thyroid disease_Homo sapiens_hsa053202.64270828
6Primary immunodeficiency_Homo sapiens_hsa053402.53573031
7Phototransduction_Homo sapiens_hsa047442.40985514
8Nitrogen metabolism_Homo sapiens_hsa009102.15064426
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.12384089
10Type I diabetes mellitus_Homo sapiens_hsa049402.10736997
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.00856888
12Homologous recombination_Homo sapiens_hsa034401.95479280
13Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.83579481
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.76936798
15Linoleic acid metabolism_Homo sapiens_hsa005911.76828402
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.74577233
17Butanoate metabolism_Homo sapiens_hsa006501.57147732
18RNA polymerase_Homo sapiens_hsa030201.48770783
19Antigen processing and presentation_Homo sapiens_hsa046121.48426583
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48273971
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45684181
22Base excision repair_Homo sapiens_hsa034101.45490607
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.45335057
24Ether lipid metabolism_Homo sapiens_hsa005651.42734290
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38250291
26Tryptophan metabolism_Homo sapiens_hsa003801.37165558
27Staphylococcus aureus infection_Homo sapiens_hsa051501.30916561
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30713057
29Arachidonic acid metabolism_Homo sapiens_hsa005901.29443162
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.27667216
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27112852
32Peroxisome_Homo sapiens_hsa041461.23178010
33Hematopoietic cell lineage_Homo sapiens_hsa046401.22741551
34Rheumatoid arthritis_Homo sapiens_hsa053231.21244429
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20059129
36Fanconi anemia pathway_Homo sapiens_hsa034601.19585356
37Chemical carcinogenesis_Homo sapiens_hsa052041.19513225
38African trypanosomiasis_Homo sapiens_hsa051431.17072586
39Caffeine metabolism_Homo sapiens_hsa002321.15869887
40Propanoate metabolism_Homo sapiens_hsa006401.13895934
41Olfactory transduction_Homo sapiens_hsa047401.04385626
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.03841618
43Leishmaniasis_Homo sapiens_hsa051401.03690846
44Systemic lupus erythematosus_Homo sapiens_hsa053221.01337733
45Oxidative phosphorylation_Homo sapiens_hsa001900.98271139
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98035232
47Other glycan degradation_Homo sapiens_hsa005110.96902665
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95762668
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95667963
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.95592309
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93511028
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91592027
53Parkinsons disease_Homo sapiens_hsa050120.88429012
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87395411
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83999830
56Basal transcription factors_Homo sapiens_hsa030220.81662704
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80586578
58Pyrimidine metabolism_Homo sapiens_hsa002400.80439898
59Retinol metabolism_Homo sapiens_hsa008300.79452525
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77636454
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.76866908
62Ribosome_Homo sapiens_hsa030100.75148065
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73959748
64Protein export_Homo sapiens_hsa030600.73607441
65Selenocompound metabolism_Homo sapiens_hsa004500.73606897
66Regulation of autophagy_Homo sapiens_hsa041400.71528863
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.71283930
68Purine metabolism_Homo sapiens_hsa002300.70381939
69RNA degradation_Homo sapiens_hsa030180.69774650
70Herpes simplex infection_Homo sapiens_hsa051680.69343468
71Renin-angiotensin system_Homo sapiens_hsa046140.67089629
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.66904303
73Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66793232
74Salivary secretion_Homo sapiens_hsa049700.65764878
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63925155
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63115877
77One carbon pool by folate_Homo sapiens_hsa006700.60505683
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60396496
79Viral myocarditis_Homo sapiens_hsa054160.59428483
80ABC transporters_Homo sapiens_hsa020100.58622790
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58431258
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.57315203
83Starch and sucrose metabolism_Homo sapiens_hsa005000.55941055
84Metabolic pathways_Homo sapiens_hsa011000.54111960
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54037503
86Sphingolipid metabolism_Homo sapiens_hsa006000.53284078
87Glycerolipid metabolism_Homo sapiens_hsa005610.51955805
88Glutathione metabolism_Homo sapiens_hsa004800.51591010
89B cell receptor signaling pathway_Homo sapiens_hsa046620.48695440
90Proteasome_Homo sapiens_hsa030500.48656228
91Platelet activation_Homo sapiens_hsa046110.47125032
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.46931441
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46644258
94Vitamin digestion and absorption_Homo sapiens_hsa049770.44834286
95Huntingtons disease_Homo sapiens_hsa050160.43214452
96Ovarian steroidogenesis_Homo sapiens_hsa049130.42685672
97Non-homologous end-joining_Homo sapiens_hsa034500.39910803
98Tuberculosis_Homo sapiens_hsa051520.38648733
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.38068599
100Histidine metabolism_Homo sapiens_hsa003400.37351818

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »